-
ADAM22 Acts as a Novel Predictive Biomarker for Unfavorable Prognosis and Facilitates Metastasis via PI3K/AKT Signaling Pathway in Nasopharyngeal Carcinoma Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-14 Kaixiong Xu, Ping Jiang, Zui Chen, Xiaoqiong Gu, Ting Zhang
Nasopharyngeal carcinoma (NPC) is a type of epithelial malignancy known for its high likelihood of metastasizing to distant organs, which remains the primary obstacle in the treatment of NPC. The present study aimed to identify potential intervention target for NPC metastasis. The differentially expressed genes (DEGs) were firstly analyzed and intersected across various NPC related datasets in the
-
Exploring the Oncogenic and Tumor-Suppressive Roles of Circ-ADAM9 in Cancer Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-13 Md Sadique Hussain, Ehssan Moglad, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Mahaveer Singh, Neelima Kukreti
Circular RNAs (circRNAs) constitute a recently identified category of closed continuous loop RNA transcripts, serving as a subset of competing endogenous RNAs (ceRNAs) with the capacity to modulate genes by acting as microRNA sponges. In the context of cancer growth, numerous investigations have explored the potential functions of circRNAs, revealing their diverse functions either as oncogenes, promoting
-
Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-12 Tian-Zi Wen, Wen-Juan Fu, Shi-Qi Xiao, Shuai Wang, Tian-Ran Li, Xin-Yu Chen, He-Yuan Chen, Jie Luo, Xiu-Wu Bian, Xiao-Hong Yao
Aberrant adrenal function has been frequently reported in COVID-19 patients, but histopathological evidence remains limited. This retrospective autopsy study aims to scrutinize the impact of COVID-19 duration on adrenocortical zonational architecture and peripheral corticosteroid reactivity. The adrenal glands procured from 15 long intensive care unit (ICU)-stay COVID-19 patients, 9 short ICU-stay
-
Expression of IZUMO2 in colorectal cancer in association with clinicopathological features Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-11 Toshiya Higashi, Hirokatsu Hayashi, Yuki Hanamatsu, Chiemi Saigo, Nobuhisa Matsuhashi, Tamotsu Takeuchi
IZUMO2 belongs to the testis-expressed IZUMO family of proteins, which are characterized by an N-terminal IZUMO domain. Based on integrated analysis of expression profiles and matched DNA methylation data from a public database, represents a prognosis-related methylation-driven gene in colorectal cancer. However, it remains unclear whether IZUMO2 protein expression is suppressed or overexpressed in
-
Melanoma on congenital melanocytic nevi Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-11 Llucia Alos, Antonio Carrasco, Cristina Teixidó, Anna Szumera-Ciećkiewicz, Asunción Vicente, Daniela Massi, Cristina Carrera
Among nevus-associated melanomas, which overall account for 20%-30% of all melanomas, those arising specifically in congenital melanocytic nevi are infrequent, but can be disproportionately frequent in childhood and adolescence. Congenital melanocytic nevi (CMNi) are common benign melanocytic tumors that are present at birth or become apparent in early childhood. They are classified based on the projected
-
Mysterious interactions between macrophage-derived exosomes and tumors; what do we know? Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-11 Raed Obaid Saleh, Ahmed Hjazi, Pooja Bansal, Irfan Ahmad, Harpreet Kaur, Saad Hayif Jasim Ali, Mahamedha Deorari, Munther Kadhim Abosaoda, Hamza Fadhel Hamzah, Bahira Abdulrazzaq Mohammed
Through their ability to modify the tumor microenvironment and cancer cells, macrophages play a crucial role in the promotion of tumorigenesis, development of tumors and metastasis, and chemotherapy resistance. A growing body of research has indicated that exosomes may be essential for coordinating the communication between cancer cells and macrophages. One type of extracellular vehicle called an exosome
-
Pollutants to Pathogens: The Role of Heavy Metals in Modulating TGF-β Signaling and Lung Cancer Risk Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-11 Asif Ahmad Bhat, Ehssan Moglad, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Riya Thapa, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Neelima Kukreti, Haider Ali
Lung cancer is a malignant tumor that develops in the lungs due to the uncontrolled growth of aberrant cells. Heavy metals, such as arsenic, cadmium, mercury, and lead, are metallic elements characterized by their high atomic weights and densities. Anthropogenic activities, such as industrial operations and pollution, have the potential to discharge heavy metals into the environment, hence presenting
-
Circular RNAs in the KRAS Pathway: Emerging Players in Cancer Progression Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-11 Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Haider Ali, Moyad Shahwan, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Circular RNAs (circRNAs) have been recognized as key components in the intricate regulatory network of the KRAS pathway across various cancers. The KRAS pathway, a central signalling cascade crucial in tumorigenesis, has gained substantial emphasis as a possible therapeutic target. CircRNAs, a subgroup of non-coding RNAs known for their closed circular arrangement, play diverse roles in gene regulation
-
Uncommon diagnosis of multinodular goiter – isolated extrapulmonary manifestation of sarcoidosis in thyroid gland (scientific case reports) Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-08 Marcel Neumann, Frank Meyer, Tatiana Oksentyuk Polyakova, Udo Barth, Dörthe Jechorek, Roland S. Croner, Manuela Petersen
-
Interleukin-22 inhibits cardiac fibrosis by regulating fibroblast metabolic reprogramming in myocardial infarction Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-07 Fang Liu, Yueqi Chen, Demeng Qin, Cheng Qian
Cardiac fibrosis, a significant characteristic of cardiovascular diseases, leads to ventricular remodeling and impaired cardiac function. In this study, we aimed to investigate the role of Interleukin-22 (IL-22) in myocardial fibrosis following myocardial infarction (MI) and to explore the underlying metabolic mechanisms. Here we analyzed the single-cell sequencing data and found that the level of
-
Critical role of Exosome, Exosomal non-coding RNAs and non-coding RNAs in Head and Neck cancer Angiogenesis Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-07 Saade Abdalkareem Jasim, Sulieman Ibraheem Shelash Al-Hawary, Irwanjot Kaur, Irfan Ahmad, Ahmed Hjazi, Iliya Petkov, Saad Hayif Jasim Ali, Ahmed huseen Redhee, Mahmood Hasen shuhata alubiady, Ahmed Muzahem Al-Ani
Head and neck cancer (HNC) refers to the epithelial malignancies of the upper aerodigestive tract. HNCs have a constant yet slow-growing rate with an unsatisfactory overall survival rate globally. The development of new blood vessels from existing blood conduits is regarded as angiogenesis, which is implicated in the growth, progression, and metastasis of cancer. Aberrant angiogenesis is a known contributor
-
LncRNAs associated with lymph node metastasis in thyroid cancer based on TCGA database Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-06 Ruijing Liu, Wen Liu, Jingli Xue, Beibei Jiang, YuQing Wei, Yiqiang Yin, Peifeng Li
Long non-coding RNA (lncRNA), especially RNA associated with lymph node metastasis, plays an important role in the development of cancer. Identifying metastasis related lncRNAs and exploring their clinical significance can guide the treatment and prognosis of thyroid cancer patients. RNA expression and clinical data of thyroid cancer was derived from The Cancer Genome Atlas (TCGA) database, while the
-
Morphologic features of prostate cancer-encased native vessels: An image analysis study Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-06 Cristina Fernandez Gonzalez De La Vega, Savannah Duenweg, Pragya Jain, Sarah I. Rubenstein, Samuel Bobholz, Michael J. Barrett, Peter S. LaViolette, Kenneth A. Iczkowski
Vasculature plays a crucial role in the progression of prostate cancer (PC). Changes to the prostatic native vessels have not been studied since 2000 when Garcia et al. demonstrated marked media hypercellularity and increased artery thickness in prostatic native arteries within PC. We aim to further evaluate and characterize prostatic native vessels with a more accurate method with the use of virtual
-
LncRNAs in necroptosis: Deciphering their role in cancer pathogenesis and therapy Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-05 Rahamat Unissa Syed, S. Afsar, Nayla Ahmed Mohammed Aboshouk, Sadeem Salem Alanzi, Rania Abdeen Hussain Abdalla, Amna Abakar Suleiman Khalifa, Jerlyn Apatan Enrera, Nancy Mohammad Elafandy, Randa Abdeen Husien Abdalla, Omar Hafiz Haj Ali, G. Satheesh Kumar, Maali D. Alshammari
Necroptosis, a controlled type of cell death that is different from apoptosis, has become a key figure in the aetiology of cancer and offers a possible target for treatment. A growing number of biological activities, including necroptosis, have been linked to long noncoding RNAs (lncRNAs), a varied family of RNA molecules with limited capacity to code for proteins. The complex interactions between
-
The molecular mechanisms of various long non-coding RNA (lncRNA) in human lung tumors: shedding light on the molecular mechanisms Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-05 S, h, a, r, i, f, , A, l, h, a, j, l, a, h
Although it is still mostly incomplete, unraveling the gene expression networks controlling the initiation and progression of cancer is crucial. The rapid identification and characterization of long noncoding RNAs (lncRNAs) is made possible by advancements in computational biology and RNA-seq technology. According to recent research, lncRNAs are involved in several stages in the genesis of lung cancer
-
miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-05 Jaber Alfaifi
Wilms' tumors (WTs) are the most common type of kidney tumor in children, and a negative outlook is generally associated with widespread anaplastic. MicroRNAs (miRNAs) are crucial in the development of WT by regulating the expression of specific genes. There is an increasing amount of research that connects the dysregulation of miRNAs to the development of various renal illnesses. The conditions encompassed
-
ENDOBRONCHIAL SOLITARY FIBROUS TUMORS: AN ENIGMA FOR DIAGNOSIS Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-04 Fátima Ramalhosa, Federica Pezzuto, Francesco Fortarezza, Gianluca Canu, Davide Biondini, Eleonora Faccioli, Roberta Polverosi, Chiara Giraudo, Fiorella Calabrese
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms constituting less than 2% of all soft tissue tumors. They typically originate in the thoracic cavity, mainly in the pleura, but can also occur in other various sites such as lung parenchyma, pericardium, and bronchus. In this study, a 49-year-old non-smoking woman with a history of allergies presented to our pulmonary clinic with a chronic
-
Deciphering the Role of MicroRNAs in Diabetic Nephropathy: Regulatory Mechanisms and Molecular Insights Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-04 Nourhan M. Abdelmaksoud, Tohada M. AL-Noshokaty, Rehab Abdelhamid Ismail, Nourhan Abd El-latif, Abdallah Mansour Ahmed, Reem Mohamed, Asmaa Hamouda Mohamed, Nada Abd Elatif Khalil, Sara Sobhy Abdelhamid, Alaa Mohsen, Heba abdelaal, Ahmed Tawfik, Shereen S. Elshaer
A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression
-
Peripheral T cell lymphoma initially presenting in lung biopsies: A diagnostic challenge Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-02 Lu He, Xianzheng Gao, Fanqing Meng, Jieyu Chen, Qianyun Shi, Linyue Zhao, Jun Yang, Qiang Zhou, Hongyan Wu, Wencai Li, Zhiwen Li
Primary or secondary pulmonary involvement by peripheral T cell lymphoma (PTCL) is rare and difficult to diagnose particularly via lung biopsies. 22 cases of PTCL diagnosed initially in lung biopsies between January 2006 and November 2020 were retrospectively reviewed followed at Nanjing Drum Tower Hospital and the First Affiliated Hospital of Zhengzhou University, respectively, including clinical
-
SIRT7: A potential prognostic marker and therapeutic target in gallbladder cancer Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-02 Bo Xu, Xiaojing Cai, Guohao Cai, Guoyu Huang
Gallbladder cancer (GBC) is a highly aggressive malignancy with limited treatment options and poor prognosis. In this study, we aimed to investigate the role of SIRT7, a member of the sirtuin family, in GBC and its potential as a prognostic marker and therapeutic target. Through immunohistochemistry analysis of GBC tissue samples, we observed elevated levels of SIRT7, which were correlated with worse
-
The detailed histopathological characteristics of ovarian fibroma compared with thecoma, granulosa cell tumor, and sclerosing stromal tumor Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-02 Mousa Mobarki, Alexandra Papoudou-Bai, Shaqraa Musawi, Michel Péoc’h, Georgia Karpathiou
Ovarian fibromas are benign tumors that can present peculiar morphological features not studied sufficiently. In this retrospective study, 75 consecutive cases of ovarian fibroma were morphologically compared with 46 thecomas, 16 granulosa cell tumors, and 5 sclerosing stroma tumors for the following factors: the growth pattern as diffuse or nodular, the presence of hyaline plaques, necrosis, keloid-like
-
Prognostic value of genome-wide methylation in acute-on-chronic hepatitis B liver failure Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-03-02 Haiming Li, Shuai Gao, Jieru Yang, Ying Zhang, Xuefei, Yuchen Fan, Kai Wang
Methylation status of genome varies between pre-acute-on-chronic hepatitis B liver failure (pre-ACHBLF), acute-on-chronic hepatitis B liver failure (ACHBLF), and chronic hepatitis B patients. This study aimed to find better prognostic indicators for acute-on-chronic liver failure. The level of global genome methylation in peripheral blood mononuclear cells (PBMCs) was detected. The overall genome methylation
-
Noncoding RNAs as therapeutic targets in autophagy-related diabetic cardiomyopathy Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-28 Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Saad Alqarni, Sami M. Magam, Muhammad Nawaz, Sameer Shaikh, Ahmed Al Otaibi, Najat Masood, Kareem M. Younes
Diabetic cardiomyopathy, a multifaceted complication of diabetes mellitus, remains a major challenge in clinical management due to its intricate pathophysiology. Emerging evidence underscores the pivotal role of autophagy dysregulation in the progression of diabetic cardiomyopathy, providing a novel avenue for therapeutic intervention. Noncoding RNAs (ncRNAs), a diverse class of regulatory molecules
-
Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-28 Amir Gholamzad, Niloofar Khakpour, Elaheh Mohandesi Khosroshahi, Saba Asadi, Zeinab Khazaei Koohpar, Arash Matinahmadi, Ali Jebali, Mohsen Rashidi, Mehrdad Hashemi, Farzaneh Hasani Sadi, Mehrdad Gholamzad
For the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review
-
Beyond the genome: MALAT1's role in advancing urologic cancer care Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-28 Mohd Imran, Abida, Lina Eltaib, Muhammad Irfan Siddique, Mehnaz Kamal, Syed Mohammed Basheeruddin Asdaq, Neelam Singla, Marwan Al-Hajeili, Fatemah Abdulaziz Alhakami, Ahmed Farhan AlQarni, Altaf A. Abdulkhaliq, Ali A. Rabaan
Urologic cancers (UCs), which include bladder, kidney, and prostate tumors, account for almost a quarter of all malignancies. Long non-coding RNAs (lncRNAs) are tissue-specific RNAs that influence cell growth, death, and division. LncRNAs are dysregulated in UCs, and their abnormal expression may allow them to be used in cancer detection, outlook, and therapy. With the identification of several novel
-
Patient-derived melanoma models Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-28 Franziska Karras, Manfred Kunz
Melanoma is a very aggressive, rapidly metastasizing tumor that has been studied intensively in the past regarding the underlying genetic and molecular mechanisms. More recently developed treatment modalities have improved response rates and overall survival of patients. However, the majority of patients suffer from secondary treatment resistance, which requires in depth analyses of the underlying
-
A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-27 Saade Abdalkareem Jasim, Sulieman Ibraheem Shelash Al-Hawary, Ahmed Hjazi, Irfan Ahmad, Irwanjot Kaur, Wesam R. Kadhum, Adnan Taan Alkhafaji, Pallavi Ghildiyal, Mohammed Abed Jawad, Salim B. Alsaadi
It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and
-
Laparoscopic retroperitoneal lymphadenectomy for ovarian mixed germ cell tumor in a patient with situs inversus totalis; reporting the first case worldwide with literature review and in silico analysis Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-27 Ahmed Shoukry Hafez, Mohammed Mamdouh Asar, Sayed Farid, Ahmed Abdelsamad, Nadia M. Hamdy
Situs inversus totalis (SIT) is a rare autosomal recessive inheritance at which the abdomino-thoracic organs are mirror-image transposed. Germ cell tumors originate from the primitive germ cell of the ovary and testis. A rare association between malignant ovarian mixed germ cell tumor and SIT was presented in a 32-years-old Egyptian female, successfully treated with laparoscopic total abdominal hysterectomy
-
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-27 Xinyi Long, Huinan Jiang, Zhuogang Liu, Jing Liu, Rong Hu
Hematological malignancies such as acute myeloid leukemia (AML) have a low cure rate and a high recurrence rate. Long noncoding RNAs (LNCs) are essential regulators of tumorigenesis and progression. The role of lncRNA LINC00675 in AML has rarely been reported. This study revealed elevated LINC00675 expression in AML that promotes proliferation and inhibits apoptosis. Mechanistically, LINC00675 combines
-
Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-27 Hao-nan Zhu, Dong-liang Song, Si-nan Zhang, Zhao-jie Zheng, Xing-yu Chen, Xin Jin
Papillary thyroid carcinoma (PTC) is generally recognized as a slow-growing tumor. However, a small subset of patients may still experience relapse or metastasis shortly after therapy, leading to a poor prognosis and raising concerns about excessive medical treatment. One major challenge lies in the inadequacy of effective biomarkers for accurate risk stratification. Long non-coding RNAs (lncRNAs)
-
Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-23 H.H. Rashwan, A.M. Taher, H.A. Hassan, A.A. Awaji, C.J. Kiriacos, R.A. Assal, R.A. Youness
Evidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular
-
Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-23 Shubham Singh, Sangeeta Saxena, Himani Sharma, Keshav Raj Paudel, Amlan Chakraborty, Ronan MacLoughlin, Brian G. Oliver, Gaurav Gupta, Poonam Negi, Sachin Kumar Singh, Kamal Dua
Lung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of
-
Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-23 Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Haider Ali, Moyad Shahwan, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Hairsh Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Sepsis, a potentially fatal illness caused by an improper host response to infection, remains a serious problem in the world of healthcare. In recent years, the role of ncRNA has emerged as a pivotal aspect in the intricate landscape of cellular regulation. The exploration of ncRNA-mediated regulatory networks reveals their profound influence on key molecular pathways orchestrating pyroptotic responses
-
Unraveling IGFBP3-mediated m6A modification in fracture healing Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-22 Aining Lai, Junjian Sun, Zhiyuan Dai, Long Guo, Degang Tao, Haitang Li, Bin Chen, Rong Zhou
This study investigates the role of IGFBP3-mediated m6A modification in regulating the miR-23a-3p/SMAD5 axis and its impact on fracture healing, aiming to provide insights into potential therapeutic targets. Utilizing fracture-related datasets, we identified m6A modification-related mRNA and predicted miR-23a-3p as a regulator of SMAD5. We established a mouse fracture healing model and conducted experiments
-
Unlocking the potential of exosomes in cancer research: A paradigm shift in diagnosis, treatment, and prevention Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-20 Saloomeh Khoushab, Mina Hobabi Aghmiuni, Negin Esfandiari, Mohammad Reza Roudaki Sarvandani, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Mehrdad Hashemi
Exosomes, which are tiny particles released by cells, have the ability to transport various molecules, including proteins, lipids, and genetic material containing non-coding RNAs (ncRNAs). They are associated with processes like cancer metastasis, immunity, and tissue repair. Clinical trials have shown exosomes to be effective in treating cancer, inflammation, and chronic diseases. Mesenchymal stem
-
The priority of mesenchymal stem cells treated with melatonin in ameliorating thyroid impairment induced by amiodarone. Thorough look on the apoptotic pathway Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-17 Ehab A.A. El-Shaarawy, Soheir H. Ahmed, Mogeda M. Nasrallah, Ali K. Mousa, Shereen Abdel Fattah
Amiodarone treatment has been associated with thyroid alterations. This work was planned to consider therapeutic outcome of MSCs versus MSCs treated with melatonin in minimizing amiodarone –induced deviations in thyroid.
-
Studying the correlation of inflammatory cytokines to COVID-19 disease Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-17 Nuha A. Alkhattabi, Hajer M. Alharbi, Mohammad A. Basabrain, Maryam H. Al-Zahrani, Rana A. Alghamdi, Husam Joharjy, Reham Khalifa, Nesrin I. Tarbiah
Extreme response of the immune system develops cytokine storm which might be crucial in the pathology of COVID-19. The research aims to evaluate the serum level of IL-6, TNF-α, and IP-10 in severe, mild, and pre-vaccinated one-dose COVID-19 patients and investigate their clinical value and effect in the disease development among different groups of patients. A total of 72 samples were collected 18
-
Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5 Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-17 Abdo A. Elfiky
Glucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current
-
Two effective factors in cancer: Investigating the effect of ncRNAs in cancer and also the effect of nanotherapy in its treatment Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-17 Raed Obaid Saleh, Hariadi Yuseran, Sofiene Mansouri, Anaheed Hussein Kareem, Maha Noori Shakir, Mohammed Qasim Alasheqi, Nabiyeva Naima Akhmedovna, Sheraliyeva Intizor Dilmurodovna, Ahmed Alawadi, Ali Alsalamy
Cancer remains one of the most pressing health challenges globally, necessitating ongoing research into innovative therapeutic approaches. This article explores two critical factors influencing cancer: ncRNAs and nanotherapy. The role of ncRNAs, including microRNAs and long non-coding RNAs, in cancer pathogenesis, progression, and treatment resistance is elucidated. Additionally, the potential of nanotherapy
-
Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-16 Weam M.A. Khojali, Nasrin E. Khalifa, Farhan Alshammari, S. Afsar, Nayla Ahmed Mohammed Aboshouk, Amna Abakar Suleiman Khalifa, Jerlyn Apatan Enrera, Nancy Mohammad Elafandy, Randa Abdeen Husien Abdalla, Omar Hafiz Haj Ali, Rahamat Unissa Syed, Potnuri Nagaraju
Globally, atherosclerosis a persistent inflammatory condition of the artery walls continues to be the primary cause of cardiovascular illness and death. The ncRNAs are important regulators of important signalling pathways that affect pyroptosis and the inflammatory environment in atherosclerotic plaques. Comprehending the complex interaction between pyroptosis and non-coding RNAs (ncRNAs) offers fresh
-
Tumor-stroma ratio in preoperative biopsies and matched surgical specimens in oral squamous cell carcinoma: Concordance and impact on recurrence-free and overall survival Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-16 Juliana Knief, Katrin Herber, Adrian Muenscher, Christoph Thorns, Nikolaus Moeckelmann
Stroma-richness is commonly associated with decreased survival times as well as advanced tumor stages in various malignant tumors. A previous study on laryngeal squamous cell carcinomas showed very good agreement for tumor-stroma ratio assessment between pre-treatment biopsies and resection specimens. We therefore aimed to determine whether similar results could be shown for oral squamous cell carcinomas
-
Detection of EGFR T790M mutation using liquid biopsy for non-small cell lung cancer: Utility of droplet digital polymerase chain reaction vs. cobas real-time polymerase chain reaction Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-16 Nicha Zungsontiporn, Pongsakorn Ouwongprayoon, Piyaporn Boonsirikamchai, Nophol Leelayuwatanakul, Chanida Vinayanuwattikun, Kantika Moonai, Ekkachai Khongkhaduead, Paul Scott Thorner, Shanop Shuangshoti, Chinachote Teerapakpinyo
Digital platforms for mutation detection yield higher sensitivity than non-digital platforms but lack universal positive cut-off values that correlate with the outcome of osimertinib treatment. This study determined compared droplet digital polymerase chain reaction (ddPCR) to the standard cobas assay for epithelial growth factor receptor () T790M mutation detection in patients with non-small cell
-
The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-16 Bekhzod Abdullaev, Hashem O. Alsaab, Ahmed Hjazi, Adnan Taan Alkhafaji, Ahmed Hussien Alawadi, Hamza Fadhel Hamzah
When the expression levels of metastasis suppressor-1 (MTSS1) were discovered to be downregulated in a metastatic cancer cell line in 2002, it was proposed that MTSS1 functioned as a suppressor of metastasis. The 755 amino acid long protein MTSS1 connects to actin and organizes the cytoskeleton. Its gene is located on human chromosome 8q24. The suppressor of metastasis in metastatic cancer was first
-
Biomarker discovery and validation for gastrointestinal tumors: A comprehensive review of colorectal, gastric, and liver cancers Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-16 Zaki H Hakami
Gastrointestinal (GI) malignancies, encompassing gastric, hepatic, colonic, and rectal cancers, are prevalent forms of cancer globally and contribute substantially to cancer-related mortality. Although there have been improvements in methods for diagnosing and treating GI cancers, the chances of survival for these types of cancers are still extremely low. According to the World Cancer Research International
-
The utility of FISH analysis in the diagnosis of BCOR-rearranged sarcomas Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-13 Stefania Cocchi, Marco Gambarotti, Gabriella Gamberi, Giovanna Magagnoli, Margherita Maioli, Monica Stevanin, Federica Samperi, Alberto Righi, Stefania Benini
A BCL6 corepressor (BCOR) gene alteration is a genetic signature of rare subsets of sarcomas. The identification of this alteration has recently contributed to the definition of new entities in the current WHO (2020) classification of soft tissue and bone tumours. We retrospectively examined cases of BCOR-rearranged sarcoma (BRS) to assess the reliability of the BCOR FISH analysis using an IVD (in
-
IL-33 immunohistochemical pattern of expression in neoplastic and nonneoplastic peripheral lung tissues of stage 1 o 2 lung adenocarcinoma Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-13 Marco Casciaro, Sebastiano Gangemi, Gaetano Caramori, Francesco Nucera, Giovanni Tuccari, Antonio Ieni
IL-33 is a multifaceted cytokine, plays a pivotal role in various biological processes, making it a subject of extensive research and intrigue in the field of immunology. This cytokine acts as a key regulator, effectively putting the brakes on proinflammatory nuclear factor-kappa B (NF-κB), thereby modulating chromatin compaction by promoting nucleosome-to-nucleosome interactions. IL-33's influence
-
Integrated bioinformatics approaches and expression assays identified new markers in pituitary adenomas Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-12 Parisa Esmaeili Motlagh, Elena Jamali, Nastaran Karimi, Solat Eslami, Guive Sharifi, Soudeh Ghafouri-Fard
Pituitary adenomas (PA) include about one third of primary central nervous tumors in adolescent and young adult. Despite extensive research, the underlying mechanism of PA tumorigenesis is still unknown. In the present study, through bioinformatics analysis of a PA-related dataset downloaded from GEO database, we attempted to identify pair(s) of lncRNA/target mRNA whose expression changes may be involved
-
Donors risk assessment in transplantation: From the guidelines to their real-world application Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-12 Deborah Malvi, Francesco Vasuri, Elisa Albertini, Maurizio Carbone, Luca Novelli, Claudia Mescoli, Massimo Cardillo, Fabio Pagni, Antonia D’Errico, Albino Eccher
Transplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential
-
Solitary fibrous tumor occurring at unusual sites: A clinico-pathological series of 31 cases with emphasis on its wide morphological spectrum Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-12 Giuseppe Angelico, Lucia Salvatorelli, Giada Maria Vecchio, Manuel Mazzucchelli, Giovanni Nunzio Rosano, Simone Poidomani, Gaetano Giuseppe Magro
Solitary fibrous tumor (SFT) is a relatively rare mesenchymal fibroblastic tumor occurring most commonly in adults with no gender predilection. Although the pathological diagnosis of SFT is usually straightforward, some difficulties may occasionally arise mainly due to the wide morphological spectrum exhibited by this tumor. In the present paper we aimed to evaluate the unusual clinicopathological
-
Hepatic granulomas following liver transplantation: A retrospective survey, and analysis of possible microbiological etiology Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-09 Anisoara Iordache, Kurt Fuursted, Charlotte Vestrup Rift, Allan Rasmussen, Gro Linno Willemoe, Jane Preuss Hasselby
Liver granulomas have always been a diagnostic challenge for pathologists. They have been described in up to 15% of liver biopsies and can also be seen in liver allograft biopsy specimens, but there is a paucity of information regarding the prevalence and associated etiologic factors of granulomas in liver transplanted patients. The aim of this study is to shed light on the etiology of liver granulomas
-
The potential role and mechanism of circRNAs in Ferroptosis: A comprehensive review Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-09 Javad Arabpour, Kimia Rezaei, Javad Yaghmoorian Khojini, Shokufeh Razi, Mohammad Javad Hayati, Seyed Mohammad Gheibihayat
Cell death encompasses various mechanisms, including necrosis and apoptosis. Ferroptosis, a unique form of regulated cell death, emerged as a non-apoptotic process reliant on iron and reactive oxygen species (ROS). Distinguishing itself from other forms of cell death, ferroptosis exhibits distinct morphological, biochemical, and genetic features. Circular RNAs (circRNAs), a novel class of RNA molecules
-
-
TIGIT: A potential immunotherapy target for gynecological cancers Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-07 Siyue Jiang, Wenhua Wang, Yongxiu Yang
Gynecological cancer represents a significant global health challenge, and conventional treatment modalities have demonstrated limited efficacy. However, recent investigations into immune checkpoint pathways have unveiled promising opportunities for enhancing the prognosis of patients with cancer. Among these pathways, TIGIT has surfaced as a compelling candidate owing to its capacity to augment the
-
NAA10 gene expression is associated with mesenchymal transition, dedifferentiation, and progression of clear cell renal cell carcinoma Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-07 Nguyen Xuong Duong, Thao Nguyen, Minh-Khang Le, Norifumi Sawada, Satoru Kira, Tetsuo Kondo, Takeshi Inukai, Takahiko Mitsui
We aimed to investigate the expression and prognostic role of in clear cell renal cell carcinoma (ccRCC). We performed a gene expression and survival analysis based on the human cancer genome atlas database of ccRCC patients (TCGA-KIRC). The patients in the TCGA-KIRC (n = 537) were divided into two subgroups: -low and -high expression groups. -high ccRCC exhibited higher T stages (p = 0.002), a higher
-
Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-07 Ehsan Lotfi, Azam Kholghi, Fereshteh Golab, Ali Mohammadi, Mahmood Barati
Colorectal cancer (CRC), the third most prevalent and lethal disease, accounted for approximately 1.9 million new cases and claimed nearly 861,000 lives in 2018. It is imperative to develop a minimally invasive diagnostic technique for early identification of CRC. This would facilitate the selection of patient populations most suitable for clinical trials, monitoring disease progression, assessing
-
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cellular functions modulated by endothelial cells in pancreatic cancer cells under hypoxic conditions Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-06 Miwa Takai, Narumi Yashiro, Koki Hara, Yuka Amano, Mao Yamamoto, Toshifumi Tsujiuchi
In the tumor environment, malignant characteristics of cancer cells are promoted by stromal cells under hypoxia. It is unknown whether lysophosphatidic acid (LPA) receptor-mediated signaling is involved in the regulation of cellular functions by endothelial cells in pancreatic cancer cells under hypoxic conditions. Pancreatic cancer (PANC-1) cells were co-cultured with endothelial (F2) cells and F2
-
Conjunctival leiomyosarcoma: A clinico-pathological study with in deep molecular characterization Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-05 Angela Santoro, Giuseppe Angelico, Antonino Mulè, Angelo Minucci, Federico Giannuzzi, Maria Grazia Sammarco, Monica Maria Pagliara, Maria Antonietta Blasi
Primary and metastatic leiomyosarcomas (LMS) involving the orbital region are well known to occur however, the conjunctiva represents an extremely rare site of occurrence. A 97-year-old male was referred to the Ocular Oncology Unit due to a rapidly growing painful mass (16×12×20 mm) in the nasal conjunctiva of his left eye. Wide excision followed by radiotherapy was performed. Based on the microscopic
-
Clear-cell papillary renal cell tumour: New insights into clinicopathological features and molecular landscape after renaming by 5th WHO classification Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-04 Wenhui Zhang, Liang Zhang, Zhu Wen, Jiayi Liang, Yingmei Wang, Zhe Wang, Zhiyong Yin, Linni Fan
Clear cell papillary renal cell tumour (CCPRCT) is a kind of renal epithelial cell tumor, and was renamed by the 5th WHO due to its specific epidemiology and clinicopathological characteristics. However, the biological mechanism and molecular basis of CCPRCT still need to be further clarified. This study aims to comprehensively evaluate clinicopathologic and molecular characteristics of CCPRCC, and
-
A review on the role of KCNQ1OT1 lncRNA in human disorders Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-03 Mohammad Taheri, Zeinab Shirvani-Farsani, Atefeh Harsij, Mohadeseh Fathi, Sheyda Khalilian, Soudeh Ghafouri-Fard, Aria Baniahmad
KCNQ1OT1 is an lncRNA located within gene on chromosome 11p15.5. This lncRNAs participates in the pathogenesis of a diversity of cancers as well as non-cancerous conditions. In most types of cancers, KCNQ1OT1 is regarded as an oncogene. In a wide array of cancers, high level of KCNQ1OT1 is associated with lower overall survival time. This lncRNA has been found to adsorb a variety of miRNAs, namely
-
Osteomyelitis and non-coding RNAS: A new dimension in disease understanding Pathol. Res. Pract. (IF 2.8) Pub Date : 2024-02-02 Md Sadique Hussain, Nusrat K. Shaikh, Mohit Agrawal, Muhammad Tufail, Ajay Singh Bisht, Navneet Khurana, Rajesh Kumar
Osteomyelitis, a debilitating bone infection, presents considerable clinical challenges due to its intricate etiology and limited treatment options. Despite strides in surgical and chemotherapeutic interventions, the treatment landscape for osteomyelitis remains unsatisfactory. Recent attention has focused on the role of non-coding RNAs (ncRNAs) in the pathogenesis and progression of osteomyelitis