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The effects of virtual reality neuroscience-based therapy on clinical and neuroimaging outcomes in patients with chronic back pain: a randomized clinical trial. Pain (IF 7.4) Pub Date : 2024-03-08 Marta Čeko, Tassilo Baeuerle, Lynn Webster, Tor D Wager, Mark A Lumley
Chronic pain remains poorly managed. The integration of immersive technologies (ie, virtual reality [VR]) with neuroscience-based principles may provide effective pain treatment by targeting cognitive and affective neural processes that maintain pain and therefore potentially changing neurobiological circuits associated with pain chronification and amplification. We tested the effectiveness of a novel
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Ketogenic diet mitigates opioid-induced hyperalgesia by restoring short-chain fatty acids-producing bacteria in the gut. Pain (IF 7.4) Pub Date : 2024-03-06 Joshua Crawford, Sufang Liu, Ran Tao, Phillip Kramer, Steven Bender, Feng Tao
Opioids are commonly prescribed to patients with chronic pain. Chronic opioid usage comes with a slew of serious side effects, including opioid-induced hyperalgesia (OIH). The patients with long-term opioid treatment experience paradoxical increases in nociceptive hypersensitivity, namely, OIH. Currently, treatment options for OIH are extremely lacking. In this study, we show that the ketogenic diet
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"I wish I knew then what I know now" - pain science education concepts important for female persistent pelvic pain: a reflexive thematic analysis. Pain (IF 7.4) Pub Date : 2024-03-06 Amelia K Mardon, K Jane Chalmers, Lauren C Heathcote, Lee-Anne Curtis, Lesley Freedman, Rinkle Malani, Romy Parker, Patricia B Neumann, G Lorimer Moseley, Hayley B Leake
Pain science education (PSE) provides people with an understanding of "how pain works" grounded in the biopsychosocial model of pain; it has been demonstrated to improve outcomes in musculoskeletal pain conditions. Preliminary evidence suggests PSE may be effective for female individuals with persistent pelvic pain, but how the content of PSE needs to be modified for this group remains to be determined
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MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling. Pain (IF 7.4) Pub Date : 2024-03-06 Ouyang Chen, Changyu Jiang, Temugin Berta, Bethany Powell Gray, Kenta Furutani, Bruce A Sullenger, Ru-Rong Ji
Secreted microRNAs (miRNAs) have been detected in various body fluids including the cerebrospinal fluid, yet their direct role in regulating synaptic transmission remains uncertain. We found that intrathecal injection of low dose of let-7b (1 μg) induced short-term (<24 hours) mechanical allodynia and heat hyperalgesia, a response that is compromised in Tlr7-/- or Trpa1-/- mice. Ex vivo and in vivo
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Defining suffering in pain. A systematic review on pain-related suffering using natural language processing. Pain (IF 7.4) Pub Date : 2024-03-05 Niklas Noe-Steinmüller, Dmitry Scherbakov, Alexandra Zhuravlyova, Tor D Wager, Pavel Goldstein, Jonas Tesarz
Understanding, measuring, and mitigating pain-related suffering is a key challenge for both clinical care and pain research. However, there is no consensus on what exactly the concept of pain-related suffering includes, and it is often not precisely operationalized in empirical studies. Here, we (1) systematically review the conceptualization of pain-related suffering in the existing literature, (2)
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Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience. Pain (IF 7.4) Pub Date : 2024-03-05 Luke A Pattison, Alexander Cloake, Sampurna Chakrabarti, Helen Hilton, Rebecca H Rickman, James P Higham, Michelle Y Meng, Luke W Paine, Maya Dannawi, Lanhui Qiu, Anne Ritoux, David C Bulmer, Gerard Callejo, Ewan St John Smith
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human use. Traditionally, the pain status of laboratory animals has been inferred from evoked nociceptive assays that measure their responses to noxious stimuli. The disconnect
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Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review. Pain (IF 7.4) Pub Date : 2024-03-05 Nathan Moreau, Sohaib Ali Korai, Giovanna Sepe, Fivos Panetsos, Michele Papa, Giovanni Cirillo
Botulinum toxin (BoNT), a presynaptic inhibitor of acetylcholine (Ach) release at the neuromuscular junction (NMJ), is a successful and safe drug for the treatment of several neurological disorders. However, a wide and recent literature review has demonstrated that BoNT exerts its effects not only at the "periphery" but also within the central nervous system (CNS). Studies from animal models, in fact
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Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study. Pain (IF 7.4) Pub Date : 2024-03-05 Jessica J Wong, Pierre Côté, Andrea C Tricco, Tristan Watson, Laura C Rosella
Some patients with back pain contribute disproportionately to high healthcare costs; however, characteristics of high-cost users with back pain are not well defined. We described high-cost healthcare users based on total costs among a population-based cohort of adults with back pain within the Ontario government's single-payer health system across sociodemographic, health, and behavioural characteristics
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Does pain tolerance mediate the effect of physical activity on chronic pain in the general population? The Tromsø Study. Pain (IF 7.4) Pub Date : 2024-03-05 Anders Pedersen Årnes, Mats Kirkeby Fjeld, Hein Stigum, Christopher Sivert Nielsen, Audun Stubhaug, Aslak Johansen, Laila Arnesdatter Hopstock, Bente Morseth, Tom Wilsgaard, Ólöf Anna Steingrímsdóttir
Knowledge is needed regarding mechanisms acting between physical activity (PA) and chronic pain. We investigated whether cold pain tolerance mediates an effect of leisure-time physical activity on the risk of chronic pain 7 to 8 years later using consecutive surveys of the population-based Tromsø Study. We included participants with information on baseline leisure-time PA (LTPA) and the level of cold
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The effect of unpredictability on the perception of pain: a systematic review and meta-analysis. Pain (IF 7.4) Pub Date : 2024-02-28 Fabien Pavy, Jonas Zaman, Wim Van den Noortgate, Aurelia Scarpa, Andreas von Leupoldt, Diana M Torta
Despite being widely assumed, the worsening impact of unpredictability on pain perception remains unclear because of conflicting empirical evidence, and a lack of systematic integration of past research findings. To fill this gap, we conducted a systematic review and meta-analysis focusing on the effect of unpredictability on pain perception. We also conducted meta-regression analyses to examine the
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ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates. Pain (IF 7.4) Pub Date : 2024-02-28 Man-Xiu Xie, Jun-Hua Rao, Xiao-Yu Tian, Jin-Kun Liu, Xiao Li, Zi-Yi Chen, Yan Cao, An-Nan Chen, Hai-Hua Shu, Xiao-Long Zhang
Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated transcription factor 4 (ATF4) belongs to the ATF/CREB transcription factor family and primarily participates in the regulation of gene transcription. Our previous study has demonstrated that ATF4 is expressed in sensory neurons. Nevertheless
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Low-frequency (5-Hz) stimulation of ventrolateral periaqueductal gray modulates the descending serotonergic system in the peripheral neuropathic pain. Pain (IF 7.4) Pub Date : 2024-02-28 Minkyung Park, Chin Su Koh, Heesue Chang, Tae Jun Kim, Wonki Mun, Jin Woo Chang, Hyun Ho Jung
Neuropathic pain is a type of chronic pain that entails severe prolonged sensory dysfunctions caused by a lesion of the somatosensory system. Many of those suffering from the condition do not experience significant improvement with existing medications, resulting in various side effects. In this study, Sprague-Dawley male rats were used, and long-term deep brain stimulation of the ventrolateral periaqueductal
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Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain (IF 7.4) Pub Date : 2024-02-27 Pau Yen Wu, Ana Isabel Caceres, Jiegen Chen, Jamie Sokoloff, Mingjian Huang, Gurpreet Singh Baht, Andrea G Nackley, Sven-Eric Jordt, Niccolò Terrando
Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the development of safe and effective therapies to prevent the onset and chronification of pain after orthopedic surgery. We established a tibial fracture
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Aged females unilaterally hypersensitize, lack descending inhibition, and overexpress alpha1D adrenergic receptors in a murine posttraumatic chronic pain model. Pain (IF 7.4) Pub Date : 2024-02-27 Silke J Hirsch, Alexandra Budig, Sanar Husam, Frank Birklein
Vulnerability to chronic pain is found to depend on age and sex. Most patients with chronic pain are elderly women, especially with posttraumatic pain after bone fracture that prevails beyond the usual recovery period and develops into a complex regional pain syndrome (CRPS). There, a distal bone fracture seems to initiate a pathophysiological process with unknown mechanism. To investigate whether
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Chemotherapy-induced peripheral neuropathy models constructed from human induced pluripotent stem cells and directly converted cells: a systematic review. Pain (IF 7.4) Pub Date : 2024-02-21 Pascal S H Smulders, Kim Heikamp, Jeroen Hermanides, Markus W Hollmann, Werner Ten Hoope, Nina C Weber
Developments in human cellular reprogramming now allow for the generation of human neurons for in vitro disease modelling. This technique has since been used for chemotherapy-induced peripheral neuropathy (CIPN) research, resulting in the description of numerous CIPN models constructed from human neurons. This systematic review provides a critical analysis of available models and their methodological
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Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain (IF 7.4) Pub Date : 2024-02-20 Emma Hertel, Lars Arendt-Nielsen, Anne Estrup Olesen, Michael Skipper Andersen, Kristian Kjær-Staal Petersen
Substantial interindividual variability characterizes osteoarthritis (OA) pain. Previous findings identify quantitative sensory testing (QST), psychological factors, and health-related quality of life as contributors to OA pain and predictors of treatment outcomes. This exploratory study aimed to explain baseline OA pain intensity and predict OA pain after administration of a nonsteroidal anti-inflammatory
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Do current methods of measuring the impact of chronic pain on work reflect the experience of working-age adults? An integrated mixed-methods systematic narrative review. Pain (IF 7.4) Pub Date : 2024-02-20 Anne L Stagg, Ira Madan, Nicola Fear, Martin J Stevens, Elaine Wainwright, Jan L Hoving, Gary J Macfarlane, Rosemary Hollick, LaKrista Morton
Chronic pain affects individuals' work participation. The impact of chronic pain on work has historically been measured through sickness absence, though it is now appreciated that the impacts on work are far wider. This mixed-methods review aimed to identify the full range of impacts of pain on work in addition to impacts that are currently measured quantitatively to inform the development of a new
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Causal associations of central and peripheral risk factors with knee osteoarthritis: a longitudinal and Mendelian Randomisation study using UK Biobank data. Pain (IF 7.4) Pub Date : 2024-02-13 William David Thompson, Subhashisa Swain, Sizheng Steven Zhao, Carol Coupland, Changfu Kuo, Michael Doherty, Weiya Zhang
Our aim was to investigate relative contributions of central and peripheral mechanisms to knee osteoarthritis (OA) diagnosis and their independent causal association with knee OA. We performed longitudinal analysis using data from UK-Biobank participants. Knee OA was defined using International Classification of Diseases manual 10 codes from participants' hospital records. Central mechanisms were proxied
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Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses. Pain (IF 7.4) Pub Date : 2024-02-13 Eric S McCoy, Sang Kyoon Park, Rahul P Patel, Dan F Ryan, Zachary J Mullen, Jacob J Nesbitt, Josh E Lopez, Bonnie Taylor-Blake, Kelly A Vanden, James L Krantz, Wenxin Hu, Rosanna L Garris, Magdalyn G Snyder, Lucas V Lima, Susana G Sotocinal, Jean-Sebastien Austin, Adam D Kashlan, Sanya Shah, Abigail K Trocinski, Samhitha S Pudipeddi, Rami M Major, Hannah O Bazick, Morgan R Klein, Jeffrey S Mogil, Guorong
Facial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we developed a cloud-based software platform called PainFace (http://painface.net) that uses machine learning to detect 4 facial action units of the mouse grimace scale (orbitals, nose, ears, whiskers) and score facial grimaces of black-coated C57BL/6
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Musculoskeletal pain in 13-year-old children: the generation R study. Pain (IF 7.4) Pub Date : 2024-02-07 Guido J van Leeuwen, Marleen M van den Heuvel, Patrick J E Bindels, Sita M A Bierma-Zeinstra, Marienke van Middelkoop
Musculoskeletal (MSK) pain is a common reason for consultation in general practice and frequently reported in children and adolescents. This study examined the prevalence of MSK pain in 13-year-old children and assessed associations with physical and psychosocial factors. Data from the Generation R Study, a population-based birth cohort, was used. Prevalence and characteristics of MSK pain were assessed
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Concurrent and lagged associations among pain medication use, pain, and negative affect: a daily diary study of people with chronic low back pain. Pain (IF 7.4) Pub Date : 2024-02-07 John W Burns, James Gerhart, David A Smith, Laura Porter, Bonny Rye, Francis Keefe
People with chronic pain often attempt to manage pain and concurrent emotional distress with analgesic substances. Habitual use of such substances-even when not opioid-based-can pose side effect risks. A negative reinforcement model has been proposed whereby relief of pain and emotional distress following medication consumption increases the likelihood that the experience of elevated pain and distress
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Sex differences in facial expressions of pain: results from a combined sample. Pain (IF 7.4) Pub Date : 2024-02-07 Pia Schneider, Stefan Lautenbacher, Miriam Kunz
Facial expressions of pain play an important role in pain diagnostics and social interactions. Given the prominent impact of sex on various aspects of pain, it is not surprising that sex differences have also been explored regarding facial expressions of pain; however, with inconclusive findings. We aim to further investigate sex differences in facial expressions of pain by using a large, combined
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Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome. Pain (IF 7.4) Pub Date : 2024-02-07 Katharina Mehling, Juliane Becker, Jeremy Chen, Sabrina Scriba, Gudrun Kindl, Rafael Jakubietz, Claudia Sommer, Beate Hartmannsberger, Heike L Rittner
Complex regional pain syndrome (CRPS) presents postinjury with disproportionate pain and neuropathic, autonomic, motor symptoms, and skin texture affection. However, the origin of these multiplex changes is unclear. Skin biopsies offer a window to analyze the somatosensory and vascular system as well as skin trophicity with their protecting barriers. In previous studies, barrier-protective exosomal
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Race-specific associations: inflammatory mediators and chronic low back pain. Pain (IF 7.4) Pub Date : 2024-02-06 Demario S Overstreet, Larissa J Strath, Robert E Sorge, Pavithra A Thomas, Jingui He, Asia M Wiggins, Joanna Hobson, D Leann Long, Samantha M Meints, Edwin N Aroke, Burel R Goodin
Chronic low back pain (cLBP) is a global health crisis that disproportionately burdens non-Hispanic Black (NHB) individuals, compared with those who identify as non-Hispanic White (NHW). Despite the growing personal and societal impact of cLBP, its biological underpinnings remain poorly understood. To elucidate the biological factors that underlie the racial disparities in cLBP, this study sought to
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Productivity outcomes from chronic pain management interventions in the working age population; a systematic review. Pain (IF 7.4) Pub Date : 2024-02-06 Anonnya Rizwana Chowdhury, Petra L Graham, Deborah Schofield, Daniel S J Costa, Michael Nicholas
Productivity loss because of chronic pain in the working age population is a widespread concern internationally. Interventions for chronic pain in working age adults might be expected to achieve enhanced productivity in terms of reduced costs of workers' compensation insurance, reduced disability support, and improved rates of return to work for injured workers. This would require the use of measures
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High-speed imaging of evoked rodent mechanical behaviors yields variable results that are not predictive of inflammatory injury. Pain (IF 7.4) Pub Date : 2024-02-02 Dianise M Rodríguez García, Aniko Szabo, Alexander R Mikesell, Samuel J Zorn, Ulrich Kemmo Tsafack, Anvitha Sriram, Tyler B Waltz, Jonathan D Enders, Christina M Mecca, Cheryl L Stucky, Katelyn E Sadler
Few analgesics identified using preclinical models have successfully translated to clinical use. These translational limitations may be due to the unidimensional nature of behavioral response measures used to assess rodent nociception. Advances in high-speed videography for pain behavior allow for objective quantification of nuanced aspects of evoked paw withdrawal responses. However, whether videography-based
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Pain in Parkinson disease: a deep phenotyping study. Pain (IF 7.4) Pub Date : 2024-02-01 Elena Salabasidou, Tobias Binder, Jens Volkmann, Anastasia Kuzkina, Nurcan Üçeyler
In our prospective cross-sectional study, we comprehensively characterized Parkinson disease (PD)-related pain in monocentrically recruited patients with PD using standardized tools of pain assessment and categorization. One hundred fifty patients were systematically interviewed and filled in questionnaires for pain, depression, motor, and nonmotor symptoms. Patients with PD-related pain (PD pain)
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Noninvasive neuromodulation of subregions of the human insula differentially affect pain processing and heart-rate variability: a within-subjects pseudo-randomized trial. Pain (IF 7.4) Pub Date : 2024-02-01 Wynn Legon, Andrew Strohman, Alexander In, Brighton Payne
The insula is an intriguing target for pain modulation. Unfortunately, it lies deep to the cortex making spatially specific noninvasive access difficult. Here, we leverage the high spatial resolution and deep penetration depth of low-intensity focused ultrasound (LIFU) to nonsurgically modulate the anterior insula (AI) or posterior insula (PI) in humans for effect on subjective pain ratings, electroencephalographic
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Pain memory in children: a systematic review and meta-analysis with a meta-regression. Pain (IF 7.4) Pub Date : 2024-01-31 Ferran Cuenca-Martínez, Aida Herranz-Gómez, Clovis Varangot-Reille, Elżbieta A Bajcar, Wacław M Adamczyk, Luis Suso-Martí, Przemysław Bąbel
The aim of this systematic review and meta-analysis was to analyze the accuracy of memory of pain and the variables that may influence it in children with acute, experimental, and chronic pain. We conducted a search in electronic databases from inception to February 11, 2022. Twelve observational studies and 3 randomized controlled studies were included in the study. The main outcome measure was the
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Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease. Pain (IF 7.4) Pub Date : 2024-01-29 James P Higham, Charity N Bhebhe, Rohit A Gupta, Michael M Tranter, Farah M Barakat, Harween Dogra, Natalie Bab, Eva Wozniak, Katie H Barker, Catherine H Wilson, Charles A Mein, Tim Raine, James J Cox, John N Wood, Nicholas M Croft, Paul D Wright, David C Bulmer
Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently available analgesics often lack efficacy or have intolerable side effects, driving the need for a more complete understanding of the mechanisms causing pain. Whole transcriptome gene expression analysis was performed by bulk RNA sequencing of colonic biopsies
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Interindividual variability in cold-pressor pain sensitivity is not explained by peripheral vascular responding and generalizes to a C-nociceptor-specific pain phenotype. Pain (IF 7.4) Pub Date : 2024-01-26 Richard D Martel, Georgios Papafragou, Sylvia Weigand, Roman Rolke, Dirk Prawitt, Frank Birklein, Rolf-Detlef Treede, Walter Magerl
Pain sensitivity of healthy subjects in the cold-pressor (CP) test was proposed to be dichotomously distributed and to represent a pain sensitivity trait. Still, it has not been systematically explored which factors influence this pain sensitivity readout. The aim of this study was to distinguish potential contributions of local tissue-related factors such as perfusion and thermoregulation or gain
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An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes. Pain (IF 7.4) Pub Date : 2024-01-26 Samuel Ferland, Feng Wang, Yves De Koninck, Francesco Ferrini
Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have raised hopes that analgesic treatments could one day be tailored to a patient's phenotype. Such precise treatment would require a profound understanding of the underlying mechanisms of specific pain phenotypes
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Parental experience of neonatal pain research while participating in the Parental touch trial (Petal). Pain (IF 7.4) Pub Date : 2024-01-25 Marianne van der Vaart, Annalisa G V Hauck, Roshni Mansfield, Eleri Adams, Aomesh Bhatt, Maria M Cobo, Daniel Crankshaw, Amraj Dhami, Caroline Hartley, Vaneesha Monk, Ria Evans Fry, Fiona Moultrie, Shellie Robinson, Jean Yong, Ravi Poorun, Luke Baxter, Rebeccah Slater
Parental involvement in neonatal comfort care is a core component of family-centred care. Yet, parents experience a range of positive and negative feelings when providing pain-relieving interventions for their infants. Parents of infants who participated in the Parental touch trial (Petal), a multicentre randomised controlled trial investigating the impact of gentle parental touch on neonatal pain
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The geography of arthritis-attributable pain outcomes: a county-level spatial analysis. Pain (IF 7.4) Pub Date : 2024-01-25 Feinuo Sun, Anna Zajacova, Hanna Grol-Prokopczyk
Research on the geographic distribution of pain and arthritis outcomes, especially at the county level, is limited. This is a high-priority topic, however, given the heterogeneity of subnational and substate regions and the importance of county-level governments in shaping population health. Our study provides the most fine-grained picture to date of the geography of pain in the United States. Combining
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Does the distribution of musculoskeletal pain shape the fate of long-term sick leave? A prospective cohort study with register follow-up. Pain (IF 7.4) Pub Date : 2024-01-24 Víctor Doménech-García, Sebastian Venge Skovlund, Pablo Bellosta-López, Joaquín Calatayud, Rubén López-Bueno, Lars Louis Andersen
Although multisite pain can markedly reduce work ability, the relevance of the bodily pain distribution as a predictor of long-term sick leave is still unknown. This study aimed to investigate the association between musculoskeletal pain distributions and long-term sick leave in the general working population of Denmark and included 66,177 currently employed wage earners without long-term sick leave
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Disruption of mitochondrial pyruvate oxidation in dorsal root ganglia drives persistent nociceptive sensitization and causes pervasive transcriptomic alterations. Pain (IF 7.4) Pub Date : 2024-01-23 Md Mamunul Haque, Panjamurthy Kuppusamy, Ohannes K Melemedjian
Metabolism is inextricably linked to every aspect of cellular function. In addition to energy production and biosynthesis, metabolism plays a crucial role in regulating signal transduction and gene expression. Altered metabolic states have been shown to maintain aberrant signaling and transcription, contributing to diseases like cancer, cardiovascular disease, and neurodegeneration. Metabolic gene
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The impact of perceived injustice on pain and psychological outcomes after traumatic injury: a longitudinal analysis. Pain (IF 7.4) Pub Date : 2024-01-19 Zina Trost, John Sturgeon, Stephanie Agtarap, Kenleigh McMinn, Evan McShan, Adriel Boals, Anne Arewasikporn, Michael Foreman, Ann Marie Warren
Individuals' appraisals regarding the injustice of their pain or physical injury have emerged as a significant risk factor for worse physical and psychological outcomes. Injustice appraisals are defined by perceptions of external blame for pain or injury and viewing pain or injury as a source of irreparable loss. To date, research on the impact of injustice appraisal has been primarily cross sectional
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Can observational learning reinforce open-label placebo hypoalgesia? Pain (IF 7.4) Pub Date : 2024-01-16 Justyna Brączyk, Przemysław Bąbel
Previous research has indicated that an open-label placebo can reduce pain in both healthy participants and patients with chronic pain. Because nondeceptive placebos seem to be an effective and more ethical alternative to deceptive placebos, optimizing this kind of treatment is essential. Observational learning was previously shown to induce the deceptive placebo effect; therefore, this study aimed
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Healthy women show more experimentally induced central sensitization compared with men. Pain (IF 7.4) Pub Date : 2024-01-11 Alexandros Guekos, Janis Saxer, Diego Salinas Gallegos, Petra Schweinhardt
Women more often experience chronic pain conditions than men. Central sensitization (CS) is one key mechanism in chronic pain that can differ between the sexes. It is unknown whether CS processes are already more pronounced in healthy women than in men. In 66 subjects (33 women), a thermal CS induction protocol was applied to the dorsum of one foot and a sham protocol to the other. Spatial extent [cm2]
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The effect of emotion regulation on the emotional modulation of pain and nociceptive flexion reflex. Pain (IF 7.4) Pub Date : 2024-01-11 Tyler A Toledo, Claudia N Vore, Felicitas A Huber, Jamie L Rhudy
Positive emotions inhibit pain, whereas negative emotions facilitate pain. Thus, many psychosocial interventions capitalize on this emotion-pain relationship to improve patients' abilities to regulate emotion (ie, reduce negative emotion, increase positive emotion), influence nociception, and manage pain. This study extended the existing literature to examine whether emotion regulation procedures could
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An experimental model for primary neuropathic corneal pain induced by long ciliary nerve ligation in rats. Pain (IF 7.4) Pub Date : 2024-01-11 Jinhong Wu, Tianjie Yuan, Danyun Fu, Rui Xu, Wenna Zhang, Shuangshuang Li, Jiahui Ding, Lili Feng, Ying Xia, Jijiang Wang, Wenxian Li, Yuan Han
Neuropathic corneal pain (NCP) is a new and ill-defined disease characterized by pain, discomfort, aching, burning sensation, irritation, dryness, and grittiness. However, the mechanism underlying NCP remain unclear. Here, we reported a novel rat model of primary NCP induced by long ciliary nerve (LCN) ligation. After sustained LCN ligation, the rats developed increased corneal mechanical and chemical
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Narrative bias ("spin") is common in randomised trials and systematic reviews of cannabinoids for pain. Pain (IF 7.4) Pub Date : 2024-01-11 Andrew Moore, Paige Karadag, Emma Fisher, Geert Crombez, Sebastian Straube, Christopher Eccleston
We define narrative bias as a tendency to interpret information as part of a larger story or pattern, regardless of whether the facts support the full narrative. Narrative bias in title and abstract means that results reported in the title and abstract of an article are done so in a way that could distort their interpretation and mislead readers who had not read the whole article. Narrative bias is
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Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein. Pain (IF 7.4) Pub Date : 2024-01-11 Mariko Nakamura, Akira Yoshimi, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Tomoya Miyauchi, Kunihiro Iwamoto, Mikiko Ito, Aiji Sato-Boku, Akihiro Mouri, Toshitaka Nabeshima, Norio Ozaki, Yukihiro Noda
Chronic orofacial pain (COP) is relieved by duloxetine (DLX) and frequently causes depressive symptoms. The aim of this study was to confirm effects of DLX on pain and depressive symptoms, and to associate with their effectiveness in platelet serotonin transporter (SERT) expression, which is a target molecule of DLX and plasma serotonin concentration in COP patients with depressive symptoms. We assessed
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Behavioral characterization of G-protein-coupled receptor 160 knockout mice. Pain (IF 7.4) Pub Date : 2024-01-10 Rachel M Schafer, Luigino A Giancotti, Daniel J Davis, Ivonne G Larrea, Susan A Farr, Daniela Salvemini
Neuropathic pain is a devastating condition where current therapeutics offer little to no pain relief. Novel nonnarcotic therapeutic targets are needed to address this growing medical problem. Our work identified the G-protein-coupled receptor 160 (GPR160) as a potential target for therapeutic intervention. However, the lack of small-molecule ligands for GPR160 hampers our understanding of its role
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Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspecific low back pain: a systematic review and meta-analysis. Pain (IF 7.4) Pub Date : 2024-01-10 Julie Rønne Pedersen, Rob Strijkers, Heike Gerger, Bart Koes, Alessandro Chiarotto
Little is known about the contribution of placebo effects and changes observed with no treatment in interventions for nonspecific low back pain (NSLBP). This systematic review assessed the proportions of the overall treatment effect that may be attributable to specific treatment effects, placebo effects, and changes observed with no treatment in randomized controlled trials (RCTs) in patients with
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A back-translational study of descending interactions with the induction of hyperalgesia by high-frequency electrical stimulation in rat and human. Pain (IF 7.4) Pub Date : 2024-01-09 Ryan Patel, Joseph L Taylor, Anthony H Dickenson, Stephen B McMahon, Kirsty Bannister
In humans and animals, high-frequency electrocutaneous stimulation (HFS) induces an "early long-term potentiation-like" sensitisation, where synaptic plasticity is underpinned by an ill-defined interaction between peripheral input and central modulatory processes. The relative contributions of these processes to the initial pain or nociceptive response likely differ from those that underpin development
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Opioid trends and risk factors for sustained use among children and adolescents in Israel: a retrospective cohort study. Pain (IF 7.4) Pub Date : 2024-01-09 Aviv Tuttnauer, Dor Atias, Orly Reznik, Noam Shomron, Uri Obolski
Despite growing global concern over opioids, little is known about the epidemiology of opioid use in children and adolescents. This retrospective study investigated opioid use trends and identified risk factors associated with sustained opioid use among outpatient children and adolescents in Israel. Electronic health records of 110,955 children and adolescents were used to establish opioid purchase
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Time-varying phase synchronization of resting-state functional magnetic resonance imaging reveals a shift toward self-referential processes during sustained pain. Pain (IF 7.4) Pub Date : 2024-01-09 Wutao Lou, Xiaoyun Li, Richu Jin, Weiwei Peng
Growing evidence has suggested that time-varying functional connectivity between different brain regions might underlie the dynamic experience of pain. This study used a novel, data-driven framework to characterize the dynamic interactions of large-scale brain networks during sustained pain by estimating recurrent patterns of phase-synchronization. Resting-state functional magnetic resonance imaging
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Sensing behavior change in chronic pain: A scoping review of sensor technology for use in daily life. Pain (IF 7.4) Pub Date : 2024-01-02 Diego Vitali, Temitayo Olugbade, Christoper Eccleston, Edmund Keogh, Nadia Bianchi-Berthouze, Amanda C de C Williams
Technology offers possibilities for quantification of behaviors and physiological changes of relevance to chronic pain, using wearable sensors and devices suitable for data collection in daily life contexts. We conducted a scoping review of wearable and passive sensor technologies that sample data of psychological interest in chronic pain, including in social situations. Sixty articles met our criteria
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The effect of a music-based caregiving intervention on pain intensity in nursing home patients with dementia. A cluster-randomized controlled study. Pain (IF 7.4) Pub Date : 2024-01-02 Martin Elstad Myrenget, Tone Rustøen, Audun Myskja, Milada Småstuen, Vegar Rangul, Odd Håpnes, Petter C Borchgrevink, Stephen Butler, Geir Selbæk, Bettina Husebø, Reidun Sandvik
Treatment of chronic pain in patients with dementia is challenging because they have reduced ability to report pain and are particularly vulnerable to side effects of analgesics. Different types of music-based therapy have been recommended and are used as an alternative to analgesics, but the evidence is lacking. Therefore, we performed a cluster-randomized controlled study (RCT) to reduce pain intensity
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Immigration background as a risk factor of chronic pain and high-impact chronic pain in children and adolescents living in Spain: differences as a function of age. Pain (IF 7.4) Pub Date : 2024-01-02 Josep Roman-Juan, Elisabet Sánchez-Rodríguez, Ester Solé, Elena Castarlenas, Mark P Jensen, Jordi Miró
The number of people immigrating from one country to another is increasing worldwide. Research has shown that immigration background is associated with chronic pain and pain disability in adults. However, research in this issue in children and adolescents has yielded inconsistent results. The aims of this study were to examine (1) the association between immigration background and chronic pain in children
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Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use. Pain (IF 7.4) Pub Date : 2024-01-02 Pradeep Suri, Patrick J Heagerty, Andrew Timmons, Mark P Jensen
Although many individuals with chronic pain use analgesics, the methods used in many randomized controlled trials (RCTs) do not sufficiently account for confounding by differential post-randomization analgesic use. This may lead to underestimation of average treatment effects and diminished power. We introduce (1) a new measure-the Numeric Rating Scale of Underlying Pain without concurrent Analgesic
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Increased risk of persistent neuropathic pain after traumatic nerve injury and surgery for carriers of a human leukocyte antigen haplotype. Pain (IF 7.4) Pub Date : 2023-12-22 Adriana Miclescu, Clara Rönngren, Mats Bengtsson, Torsten Gordh, Anders Hedin
It is not known why some patients develop persistent pain after nerve trauma while others do not. Among multiple risk factors for the development of persistent posttrauma and postsurgical pain, a neuropathic mechanism due to iatrogenic nerve lesion has been proposed as the major cause of these conditions. Because there is some evidence that the human leukocyte antigen (HLA) system plays a role in persistent
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The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy. Pain (IF 7.4) Pub Date : 2023-12-22 Dale S George, Nirupa D Jayaraj, Paola Pacifico, Dongjun Ren, Nikhil Sriram, Rachel E Miller, Anne-Marie Malfait, Richard J Miller, Daniela Maria Menichella
Painful diabetic neuropathy (PDN) is one of the most common and intractable complications of diabetes. Painful diabetic neuropathy is characterized by neuropathic pain accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability, axonal degeneration, and changes in cutaneous innervation. However, the complete molecular profile underlying the hyperexcitable cellular phenotype of DRG nociceptors
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Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood. The HUNT Study. Pain (IF 7.4) Pub Date : 2023-12-20 Monica Baumann-Larsen, Kjersti Storheim, Helle Stangeland, John-Anker Zwart, Tore Wentzel-Larsen, Svetlana Skurtveit, Grete Dyb, Synne Øien Stensland
Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions increase the risk of persistent use and future misuse of potent analgesics, such as opioids. Childhood trauma exposure has been found to be related to pain conditions and to using more prescription analgesics. This large, prospective cohort study aimed to investigate the association
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Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations. Pain (IF 7.4) Pub Date : 2023-12-19 Simon Haroutounian, Katherine J Holzer, Robert D Kerns, Christin Veasley, Robert H Dworkin, Dennis C Turk, Kristin L Carman, Christine T Chambers, Penney Cowan, Robert R Edwards, James C Eisenach, John T Farrar, McKenzie Ferguson, Laura P Forsythe, Roy Freeman, Jennifer S Gewandter, Ian Gilron, Christine Goertz, Hanna Grol-Prokopczyk, Smriti Iyengar, Isabel Jordan, Cornelia Kamp, Bethea A Kleykamp
In the traditional clinical research model, patients are typically involved only as participants. However, there has been a shift in recent years highlighting the value and contributions that patients bring as members of the research team, across the clinical research lifecycle. It is becoming increasingly evident that to develop research that is both meaningful to people who have the targeted condition
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Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial. Pain (IF 7.4) Pub Date : 2023-12-19 Haidar M Al-Khazali, Christina I Deligianni, Lanfranco Pellesi, Mohammad Al-Mahdi Al-Karagholi, Håkan Ashina, Basit Ali Chaudhry, Anja Sofie Petersen, Rigmor H Jensen, Faisal Mohammad Amin, Messoud Ashina
Activation of adenosine triphosphate-sensitive potassium (KATP) channels has been implicated in triggering migraine attacks. However, whether the opening of these channels provoke cluster headache attacks remains undetermined. The hallmark of cluster headache is a distinct cyclical pattern of recurrent, severe headache episodes, succeeded by intervals of remission where no symptoms are present. In
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Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines. Pain (IF 7.4) Pub Date : 2023-12-19 Amelia K Mardon, Hayley B Leake, Kimberley Szeto, G Lorimer Moseley, K Jane Chalmers
Patient education has a critical role in the management of pain. There is considerable heterogeneity in patient education for females with persistent pelvic pain (PPP), and it remains unclear what is considered best clinical practice. Therefore, this systematic review identified and summarised recommendations for patient education in the management of benign gynaecological and urological conditions
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Opioid characteristics and nonopioid interventions associated with successful opioid taper in patients with chronic noncancer pain. Pain (IF 7.4) Pub Date : 2023-12-19 Monica Jung, Ting Xia, Jenni Ilomäki, Christopher Pearce, Suzanne Nielsen
Current research indicates that tapering opioids may improve pain and function in patients with chronic noncancer pain. However, gaps in the literature remain regarding the choice of opioid and nonopioid interventions to support a successful taper. This study used an Australian primary care data set to identify a cohort of patients on long-term opioid therapy commencing opioid taper between January
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Effect of exposure-based vs traditional cognitive behavior therapy for fibromyalgia: a two-site single-blind randomized controlled trial. Pain (IF 7.4) Pub Date : 2023-12-15 Maria Hedman-Lagerlöf, Nils Gasslander, Alice Ahnlund Hoffmann, Maria Bragesjö, Amanda Etzell, Simon Ezra, Elsa Frostell, Erik Hedman-Lagerlöf, Caroline Ivert, Björn Liliequist, Brjánn Ljótsson, Johanna M Hoppe, Josefin Palmgren, Edward Spansk, Felicia Sundström, Josefin Särnholm, Georgia Tzavara, Monica Buhrman, Erland Axelsson
Fibromyalgia is a debilitating pain condition for which treatment effects are typically modest. The most evaluated psychological treatment is traditional cognitive behavior therapy (T-CBT), but promising effects have recently been seen in exposure-based cognitive behavior therapy (Exp-CBT). We investigated whether Exp-CBT was superior to T-CBT in a randomized controlled trial. Self-referred participants