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Evaluation of Naples prognostic score to predict long-term mortality in patients with pulmonary embolism Biomark. Med. (IF 2.2) Pub Date : 2024-03-15 Levent Pay, Tuğba Çetin, Kıvanç Keskin, Şeyda Dereli, Ozan Tezen, Ahmet Ç Yumurtaş, Zeynep Kolak, Semih Eren, Faysal Şaylık, Tufan Çınar, Mert İ Hayıroğlu
Background: The Naples prognostic score (NPS), which reflects the inflammatory and nutritional status of patients, is often used to determine prognosis in cancer patients. The aim of this study was to determine the long-term prognostic value of the NPS in acute pulmonary embolism (APE) patients. Methods: Two hundred thirty-nine patients diagnosed with APE were divided into two groups according to their
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Lipid accumulation product is a valid predictor of hepatic steatosis and nonalcoholic fatty liver disease Biomark. Med. (IF 2.2) Pub Date : 2024-03-08 Qiaoli Huang, Xuying Tan, Qiongmei Wu, Hanqing Zhao, Hangjun Chen, Xinxue Yu, Jinting Wang, Xueyi Huang, Yurong Huang, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Aims: To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate aminotransferase (AST), visceral adiposity index (VAI) and triglyceride-glucose index (TyG) as biomarkers for hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). Methods: LAP, ALT, AST, VAI and TyG were measured in 52 biopsy-proven NAFLD patients and 21 control subjects. Additionally
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Pharmacogenomic biomarkers in coronary artery disease: a narrative review Biomark. Med. (IF 2.2) Pub Date : 2024-03-08 Pamila Dua, Sandeep Seth, Bhavana Prasher, Mitali Mukerji, Subir Kumar Maulik, KH Reeta
Coronary artery disease (CAD) has a high mortality rate. Despite various therapeutic targets, non-responsiveness to drugs remains a prevalent issue. Pharmacogenomics assesses the way an individual's genetic attributes affect their likely response to drug therapy. Single-nucleotide polymorphisms play a crucial role in determining these outcomes. This review offers an overview of single-nucleotide polymorphisms
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Diagnostic predictability of serum miR-4793-3p and miR-1180-3p expression in community-acquired pneumonia Biomark. Med. (IF 2.2) Pub Date : 2024-03-08 Rong Chai, Cihang Zhou, Zhenli Hu, Jingjing Hu
Background: Early identification of community-acquired pneumonia (CAP) is crucial to prevent severe progression. Methods: The authors enrolled 150 hospitalized CAP patients and collected clinicopathologic features and blood indicators. Plasma miRNA profiling was conducted using microarray detection, and selected miRNAs were tested with reverse transcription quantitative PCR. Predictive models were
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Associations between neutrophil-to-lymphocyte/platelet-to-lymphocyte and recovery in sudden sensorineural hearing loss Biomark. Med. (IF 2.2) Pub Date : 2024-03-04 Xinmei Huang, Xupei Ni, Jun Shen, Lihua Chen, Liying Xu, Xuxia Tang
Aims: This study investigated the nonlinear associations between neutrophil-to-lymphocyte (NLR)/platelet-to-lymphocyte (PLR) and recovery rates in sudden sensorineural hearing loss (SSNHL). Methods: Total of 244 SSNHL patients were included. The primary outcome was recovery rate. Results: A nonlinear association was detected between NLR and recovery rate using the LOWESS method, with a knot of 3. Patients
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Linkage of CDC42 and T-helper cell ratio with anxiety, depression and quality of life in ST-elevation myocardial infarction Biomark. Med. (IF 2.2) Pub Date : 2024-03-05 Xuechao Wang, Junjie Feng, Shaohua Luan, Yong Zhou, Shipan Zhang, Hongling Su, Zhongyu Wang
Objective: To investigate the correlations between CDC42 and T-cell subsets concerning anxiety, depression and quality of life in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention. Methods: Sera from 156 participants were analyzed for CDC42 levels and Th1, Th2, Th17 and Treg cells. Results: CDC42 correlated with reduced Th1/Th2 and Th17/Treg ratios, lower anxiety
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C-reactive protein to albumin ratio may predict in-hospital mortality in non-ST elevation myocardial infarction Biomark. Med. (IF 2.2) Pub Date : 2024-03-05 Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş
Objective: The authors investigated the value of novel inflammatory markers, systemic immune-inflammation index and C-reactive protein to albumin ratio (CAR), to predict in-hospital mortality in patients with non-ST elevation myocardial infarction (NSTEMI). Materials & methods: A total of 308 patients who underwent percutaneous coronary intervention because of NSTEMI were retrospectively included in
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Study on red blood cell distribution width in children with severe Mycoplasma pneumoniae pneumonia Biomark. Med. (IF 2.2) Pub Date : 2024-03-05 Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang
Background: This study aimed to investigate the clinical value of the red blood cell distribution width (RDW) in severe Mycoplasma pneumoniae pneumonia (MPP). Methods: A total of 185 children with diagnosed severe MPP were included. The patients’ case records and laboratory examination data were analyzed retrospectively. The children were grouped into quartiles based on RDW. Results: Univariate analysis
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PLK4 reflects extrathyroidal invasion, high tumor stage and poor prognosis in papillary thyroid carcinoma patients Biomark. Med. (IF 2.2) Pub Date : 2024-03-05 Xiaonan Hu, Jiawei Yu, Mengshi Chen, Rui Pang
Objective: This study aimed to assess the value of PLK4 as a biomarker in papillary thyroid carcinoma (PTC). Methods: This study reviewed 230 PTC patients receiving surgical resections. PLK4 was detected in tumor tissues and samples of normal thyroid gland tissues by immunohistochemistry. Results: PLK4 was elevated in tumor tissues versus normal thyroid gland tissues (p < 0.001). Tumor PLK4 was linked
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Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients Biomark. Med. (IF 2.2) Pub Date : 2024-03-05 Juxian Gu, Chao Liu, Yan Yao
Objective: This study aimed to investigate the prognostic potency of LRG1 in acute ischemic stroke (AIS) patients. Methods: Plasma LRG1 levels were detected at admission and on days 3, 7 and 30 in 150 AIS patients. Results: LRG1 positively correlated with total cholesterol (p = 0.016), triglycerides (p = 0.046), C-reactive protein (p < 0.001), TNF-α (p = 0.001) and IL-6 (p = 0.004). After admission
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Emerging roles of HOTAIR lncRNA in the pathogenesis and prognosis of cardiovascular diseases Biomark. Med. (IF 2.2) Pub Date : 2024-02-27 Habib Haybar, Hakimeh Hadi, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Highlights HOTAIR, a long noncoding RNA, plays a role in the regulation of proteins involved in the pathogenesis of cardiovascular disease. Furthermore, it has been identified as a biomarker of this type of disease. Several factors and cells contribute to atherosclerosis, a progressive disease. However, the prognosis of HOTAIR in this disease varies depending on the path in which it plays a role. For
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Meta-analysis of initial natriuretic peptides in the setting of sepsis-induced myocardial dysfunction Biomark. Med. (IF 2.2) Pub Date : 2024-02-21 Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao
Aim: To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0. Methods: Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups. Results: Eighteen studies were included, most of which defined SIMD based
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Predictive role of neutrophil-to-platelet ratio in futile recanalization of patients after endovascular therapy Biomark. Med. (IF 2.2) Pub Date : 2024-02-20 Bing-Hu Li, Li-Rong Wang, Jie Huang, Shu Yang, Bin Huang, Li-Jun Jia, Sen Zhou, Fu-Qiang Guo, Jian-Hong Wang, Neng-Wei Yu
Aim: To explore the association between the neutrophil-to-platelet ratio (NPR) and futile recanalization (FR) in patients with acute ischemic stroke due to large vascular occlusions after endovascular therapy (EVT). Methods: FR after EVT was defined as a poor 90-day prognosis (modified Rankin scale [mRS] score ≥3) despite successful reperfusion (modified thrombolysis in cerebral infarction grade 2b–3)
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B-type natriuretic peptide levels at admission predict the prognosis of patients with infective endocarditis undergoing cardiac surgery Biomark. Med. (IF 2.2) Pub Date : 2024-02-15 Ning Sun, Junyong Zhao, Wenjian Luo, Xiaolin Luo, Shaofa Wu, Zelan Wang, Pengda Li, Jia Li, Renjie Zhou, Shulin Ou, Zhexue Qin
Purpose: The objective of this study was to explore the relationship between elevated B-type natriuretic peptide (BNP) levels and the prognosis of patients with infective endocarditis (IE) undergoing cardiac surgery. Methods: In total, 162 IE patients with recorded BNP levels upon admission were included in the present study. The primary end point was all-cause mortality. Results: Multivariate Cox
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Platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio in glaucoma: a meta-analysis Biomark. Med. (IF 2.2) Pub Date : 2024-02-09 Shu-Han Chuang, Cheng-Hsien Chang
Aim: To explore the association between two systemic inflammation markers, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and glaucoma. Materials & methods: The authors searched PubMed, Embase and the Cochrane Library for eligible studies comparing PLR and LMR levels in glaucoma patients and healthy controls. Results: Analysis revealed that glaucoma patients exhibited significantly
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Comparison of the effect of uric acid/albumin ratio on coronary slow flow with other inflammation-based markers Biomark. Med. (IF 2.2) Pub Date : 2024-02-07 Kenan Toprak, Kaya Özen, Tolga Memioğlu, Mehmet İnanır, Mustafa Kaplangöray, Selahattin Akyol, Mustafa B Tascanov, Asuman Biçer, Recep Demirbağ
Background: Many inflammation-based markers (IBMs) have been shown to be closely related to coronary slow flow (CSF), but the effect of the uric acid/albumin ratio (UAR) on CSF and its relationship with other IBMs are not clearly known. In this study, we aimed to compare the effects of UAR and other IBMs on CSF. Methods: After the exclusion criteria, 126 patients with CSF detected on coronary angiography
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Assessment of biomarker stability and assay performance parameters for medical diagnosis: a case study of diagnosis of major depressive disorder Biomark. Med. (IF 2.2) Pub Date : 2024-02-02 Mike Jentsch, Barry van der Strate, Marjolein Meddens, Marcus Meddens, Robert Schoevers
Aim: Assessing the stability profiles and assay performance of 24 biomarker assays in 32 biomarker/body fluid combinations identified as relevant for prediction of major depressive disorder. Materials & methods: Combinations were tested for stability and assay performance with ELISA at different storage and freeze–thaw conditions in pooled samples of 40 patients. Results: Stability and assay performance
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High-density lipoprotein-related inflammatory indices predict repeat revascularization in coronary drug-eluting stenting Biomark. Med. (IF 2.2) Pub Date : 2024-01-17 Xuantong Guo, Ruihuan Shen, Yanni Su, Lihong Ma
Background: HDL-C-related inflammatory indices are potential predictors of repeat revascularization (RR) after coronary drug-eluting stenting. Methods: Multivariable Cox regression with restricted cubic splines and receiver operating curve was used. Results: The median follow-up was 50 months. A total of 521 (35.42%) patients experienced RR. The incidence of RR was positively associated with the monocyte-to-HDL-C
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Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients Biomark. Med. (IF 2.2) Pub Date : 2024-01-17 Ane Karoline Medina Néri, Ricardo Pereira Silva, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins, Ana Ofélia Portela Lima, Cesário Rui Callou Filho, Francisco Daniel Cavalcante Vidal, Jeruza Mara de Oliveira Lima, Eduardo Arrais Rocha, Geraldo Bezerra da Silva Júnior
Background: Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics. Aim: To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics. Methods: Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics. Results: Higher VCAM-1 levels
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Predictive value of blood biomarkers in elderly patients with non-small-cell lung cancer Biomark. Med. (IF 2.2) Pub Date : 2024-01-18 Lianghua Guo, Bin Song, Jianhong Xiao, Hui Lin, Junhua Chen, Baoren Jian
Aim: Whether GRHL1 can be considered as a potential biomarker for screening non-small-cell lung cancer (NSCLC) is still uncertain. We aimed to investigate the value of circulating blood GRHL1 on detecting NSCLC in an older population. Materials & methods: Diagnostic models from 351 older patients with NSCLC were constructed to assess the predictive value of blood GRHL1 on distinguishing NSCLC. Results:
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Can C-reactive protein be used as a surrogate marker of IL-6 in a broad array of clinical entities? Biomark. Med. (IF 2.2) Pub Date : 2024-01-18 Syed B Ali, Amelia Cecchin, Cristina Lucchesi, Trishni Putty, Suzanne Edwards, Tina Petrou, Penelope Coates, Antonio Ferrante, Phillippa A Pucar, Jovanka King, Tatjana Banovic
Background: C-reactive protein (CRP) is commonly performed, whereas cytokine testing is limited to research. Aims: To determine CRP correlation to cytokines IL-6, IL-1β and TNF-α. Results: Consecutive samples (n = 307) were collected over 24 h. Ninety-six patients (31%) had acute infections, and 23 patients (7.5%) had autoimmune or inflammatory disease presentations. A strong correlation between CRP
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Role of inflammation following an acute myocardial infarction: design of INFINITY Biomark. Med. (IF 2.2) Pub Date : 2024-01-18 Andreas Mitsis, Panayiotis Avraamides, John Lakoumentas, Michaela Kyriakou, Stefanos Sokratous, Georgia Karmioti, Michail Drakomathioulakis, Konstantinos C Theodoropoulos, Athina Nasoufidou, Alexandros Evangeliou, Vassilios Vassilikos, Nikolaos Fragakis, Antonios Ziakas, Stergios Tzikas, George Kassimis
After a myocardial infarction, the inflammatory response is connected to major adverse outcomes such as ischemia-reperfusion injury, adverse cardiac remodeling, infarct size and poor prognosis. INFlammatIoN amI sTudY (INFINITY) is a multicenter, prospective, observational, cohort study designed to investigate the prognostic role of the cytokines IL-6, IL-10, IL-18 and IL-17 and the adipokines leptin
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Nomogram for predicting prolonged postoperative ileus in colorectal cancer based on age and inflammatory markers Biomark. Med. (IF 2.2) Pub Date : 2024-01-18 Zong-Qi Fan, Yang Chen, Xin-Ao Fu, Hao-Ting Yin, Ju-Shang Li, Wei-Si Wang, Jie-Qing Yuan, Shi-Gang Guo
Aim: To explore the relationship between inflammatory markers and prolonged postoperative ileus (PPOI), and to establish a nomogram for predicting PPOI. Patients & methods: The data of 229 patients were analyzed retrospectively. Univariate and multivariate logistic regression analysis were used to analyze the risk factors affecting the occurrence of PPOI. The predictive model of PPOI was established
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Prognostic value of MTSS1 gene expression on acute leukemia patients outcome Biomark. Med. (IF 2.2) Pub Date : 2024-01-17 Salah Aref, Mohamed Sabry, Nadia El Menshawy, Ahmed Aref, Ahmed El Tantawy, Mohamed Ayed, Ahmed EL-Sebaie
Background: This study aimed to evaluate the prognostic value of the MTSS1 gene expression in patients with acute leukemia. Patients & methods:MTSS1 gene expression was quantified in 120 newly diagnosed acute leukemia patients, by quantitative reverse transcription PCR at diagnosis and after induction chemotherapy therapy. Results: Baseline MTSS1 gene expression was significantly higher in acute leukemia
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Impact of estrogen and progesterone receptor expression on the incidence of endometrial polyps Biomark. Med. (IF 2.2) Pub Date : 2024-01-17 Cuiyun Yan, Chunping Xing, Tao Wei, Hui Zhou, Hua Wang, Tao Liu, Jiefang Gao
Aim: We studied the association of estrogen receptor (ER) and progesterone receptor (PR) with endometrial polyp (EP) formation. Methods: A total of 129 EP patients and an equal number of disease-free women were evaluated for ER and PR expression in endometrial tissues. Correlation with EP incidence was analyzed, as well as diagnostic value via receiver operating characteristic curve. Results: ER expression
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Integrative bioinformatics analysis identifies APOB as a critical biomarker in coronary in-stent restenosis Biomark. Med. (IF 2.2) Pub Date : 2024-01-15 Xinghua Bai, Weizong Zhang, Tao Yu
Aim: Coronary artery disease (CAD) is a major contributor to the worldwide prevalence of cardiovascular disease. In-stent restenosis (ISR) is a common complication which can lead to stent implantation failure, necessitating repeated intervention and presenting a significant obstacle for CAD management. Methods: To accurately assess and determine the hub genes associated with ISR, CAD databases from
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Sepsis screening tools for predicting infection triggers and outcomes in diabetic ketoacidosis Biomark. Med. (IF 2.2) Pub Date : 2024-01-12 Abhishek Kumar, Ashok Kumar Pannu, Mohan Kumar, Archana Angrup, Pinaki Dutta, Navneet Sharma
Background: An early prediction of infection is challenging in diabetic ketoacidosis (DKA). Methods: This prospective cohort study aimed to assess effectiveness of various sepsis screening tools in predicting infections and prognosis in DKA. Results: Among 141 cases, infection (44.0%) was the commonest precipitating factor. A Sequential Organ Failure Assessment score ≥4 showed high specificity (82
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Development and validation of a nomogram for predicting intraoperative hypotension in cardiac valve replacement Biomark. Med. (IF 2.2) Pub Date : 2024-01-12 Lei Wang, Liqiong Xiao, Lanyue Hu, Xin Chen, Xiaoliang Wang
Background: Cardiac valve replacement risks include intraoperative hypotension, endangering organ perfusion. Our nomogram predicted hypotension risk in valve surgery, guiding early intervention. Methods: Analyzing 561 patients from July to November 2022, we developed a nomogram to predict hypotension in valve replacement patients, validated using data from December 2022 to January 2023 on 241 patients
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Application value of miRNA-182 as a biomarker for cancer diagnosis: a systematic review with meta-analysis Biomark. Med. (IF 2.2) Pub Date : 2024-01-11 Mengyu Shang, Mengdan Ma, Ganglin Su, Liang Xiao
Aim: This study aims to establish the potential reliability and validity of miRNA-182 as a diagnostic tool in oncology, and hence to contribute to the decision-making process in clinical settings. Materials & methods: To further evaluate the role of miRNA-182 as a cancer biomarker, we conducted a search of the PubMed, Cochrane Library, Wanfang and China National Knowledge Infrastructure databases of
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AAT: does it have a place in acute leukemia? Biomark. Med. (IF 2.2) Pub Date : 2024-01-10 Mehmet H Dogu, Berfin Ozcelik, Yusuf E Akbulut, Mert Kantarci, Ezgi Bektas, Istemi Serin
Aim: In this study, the authors aimed to investigate the change of AAT, its effect on the response to induction and its effects on the treatment process in acute myeloid leukemia and acute lymphoblastic leukemia patients. Materials & methods: This study included 94 patients who were hospitalized and followed up in Istanbul Training and Research Hospital, Hematology Clinic, between October 2019 and
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Relationship between platelet/hemoglobin and radial thrombus in patients with coronary angiography via radial access Biomark. Med. (IF 2.2) Pub Date : 2024-01-10 Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan
Aim: To predict the development of radial artery thrombus (RAT) in patients with radial approach coronary angiography of platelet-to-hemoglobin ratio (PHR). Materials & methods: This study was designed to evaluate the relationship between RAT and PHR. A total of 1156 patients who had coronary angiography via the transradial approach between 2021 and 2022 in the authors' center were included in the
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TCF21 rs2327429 and TCF21 rs12190287 are associated with colorectal cancer in a Chinese population Biomark. Med. (IF 2.2) Pub Date : 2024-01-10 Jian-Guo Wang, Xia-Fang Jin, Yi-Min Huang, Zheng-Fen Xu, Shou-Ju Huang, Yingjie Zhu, Ling Ai, Tian Hang
Aims:TCF21 is considered a tumor suppressor gene. This work was designed to explore the associations between TCF21 polymorphisms and colorectal cancer (CRC) susceptibility. Methods: A case-control study was designed with 421 patients with CRC and 469 non-CRC controls. Six tagging single-nucleotide polymorphisms (rs2327429 T>C, rs2327430 T>C, rs2327433 A>G, rs12190287 C>G, rs7766238 G>A and rs4896011
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Platelet-to-albumin ratio is a potential biomarker for predicting diabetic nephropathy in patients with type 2 diabetes Biomark. Med. (IF 2.2) Pub Date : 2024-01-05 Shi-Lu Cao, Guo-Qing Zhang, Jing Li, Li Bao, Xiao-Mei Lan, Quan-Peng Jin, Hong-Yan Luo, Jing E, Bo Li, Danna Ma, Xi Bao, Ya-Li Zheng
Aim: To evaluate whether platelet-to-albumin ratio (PAR) can predict diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). Materials & methods: A total of 140 patients with T2DM and 40 healthy individuals were enrolled retrospectively. T2DM patients were divided into three groups based on the urinary albumin-to-creatinine ratio, PAR was compared and receiver operating characteristic curve was
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Application of 24-h respiratory rate and oxygenation index variation to predict the outcome of high-flow nasal cannula therapy in patients with acute hypoxemic respiratory failure in a Respiratory Intensive Care Unit Biomark. Med. (IF 2.2) Pub Date : 2024-01-05 Jing Ge, Danhong Zhou, Yang Wang, Weiwei Ning, Beilei Zhang, Cheng Chen
Background: An evaluation system is urgently needed to describe early predictors of the outcome of high-flow nasal cannula (HFNC) oxygen therapy in acute hypoxemic respiratory failure (AHRF) patients. Methods: All consecutive AHRF patients in a Respiratory Intensive Care Unit (RICU) receiving HFNC therapy between January 2019 and December 2021 were enrolled. Results: Of the 106 enrolled AHRF subjects
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Serum JKAP reflects Th2 and Th17 cell levels, and diabetic nephropathy risk and severity in diabetes mellitus patients Biomark. Med. (IF 2.2) Pub Date : 2024-01-05 Meili Tong, Changrui Gu, Qiuzhi Yu, Jian Ma
Objective: This study aimed to explore the potency of serum JKAP for estimating diabetic nephropathy risk in diabetes mellitus (DM) patients. Methods: Serum JKAP was detected in 212 DM patients. According to urinary albumin-to-creatinine ratio, DM patients were divided into normoalbuminuria, microalbuminuria and macroalbuminuria groups. Results: JKAP declined in the macroalbuminuria group versus normoalbuminuria
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Biomarkers in exhaled breath condensate as fingerprints of asthma, chronic obstructive pulmonary disease and asthma–chronic obstructive pulmonary disease overlap: a critical review Biomark. Med. (IF 2.2) Pub Date : 2024-01-05 Behrouz Seyfinejad, Emirhan Nemutlu, Ali Taghizadieh, Maryam Khoubnasabjafari, Sibel A Ozkan, Abolghasem Jouyban
Asthma, chronic obstructive pulmonary disease (COPD) and asthma–COPD overlap are the third leading cause of mortality around the world. They share some common features, which can lead to misdiagnosis. To properly manage these conditions, reliable markers for early and accurate diagnosis are needed. Over the past 20 years, many molecules have been investigated in the exhaled breath condensate to better
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Could serum HMGB1 levels be a predictor associated with psoriatic arthritis? Biomark. Med. (IF 2.2) Pub Date : 2023-12-20 Derya Yildirim, Merve Baykul, Yusuf C Edek, Mehmet Gulengul, Gizem T Alp, Fatma S Eroglu, Esra Adisen, Hamit Kucuk, Abdulsamet Erden, Berna Goker, Kemal Nas, Mehmet A Ozturk
Background/aim: Psoriasis is a chronic autoimmune disease that predominantly affects the skin and musculoskeletal system. We hypothesized that HMGB1, an inflammatory nuclear protein, may play a role in the musculoskeletal involvement of psoriasis. Methods: Forty patients with psoriasis and 45 with psoriatic arthritis were involved in the study; the results were compared with 22 healthy controls. Serum
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Diagnostic value of serum autotaxin level in colorectal cancer Biomark. Med. (IF 2.2) Pub Date : 2023-12-14 Abdurrahman Başpınar, Didem Özkan, Serhat Tokgöz, Alper Bilal Özkardeş, İsmail Oskay Kaya
Background: Autotaxin (ATX) is a nucleotide enzyme linked to cell growth, differentiation and migration. This study investigated serum levels of ATX in colorectal cancer (CRC). Methods: The study involved stage I–III CRC diagnosed between December 2020 and 2021, excluding those with neoadjuvant or adjuvant therapy, or metastasis. Healthy volunteers were controls. Serum ATX levels were measured by ELISA
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Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma Biomark. Med. (IF 2.2) Pub Date : 2023-12-14 Qiuli Liang, Shun Liu, Fuqiang Yin, Meiliang Liu, Lijun Wang, Erna Guo, Lei Lei, Liuyu Wu, Yu Yang, Di Zhang, Xiaoyun Zeng
Background: To explore the biological function and the underlying mechanisms of GOT2 in hepatocellular carcinoma (HCC). Materials & methods: The expression level and prognostic value of GOT2 were examined using International Cancer Genome Consortium and International Cancer Proteogenome Consortium databases. The cell counting kit-8 method, clone formation, Transwell® assays and western blotting were
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The emerging role of miR-320a in lung cancer: a comprehensive review Biomark. Med. (IF 2.2) Pub Date : 2023-12-14 Adrija Mohanta, Rajiv R Kumar, Rahul K Singh, Surojit Mandal, Ritu Yadav, Rinku Khatkar, Uttam Sharma, Vivek Uttam, Manjit K Rana, Amrit PS Rana, Aklank Jain
A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. We found that miR-320a modulates levels of diverse cancer-associated molecules and signaling pathways, and is also involved in modulating the immune
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Prognostic value of the Lung Immune Prognostic Index for HER-2-negative metastatic gastric cancer Biomark. Med. (IF 2.2) Pub Date : 2023-12-12 Miaomiao Gou, Yong Zhang, Tongtong Qu, Ru Jia, Zhikuan Wang, Guanghai Dai
Background: The aim of this study was to explore whether the Lung Immune Prognostic Index (LIPI) is associated with clinical outcomes in patients with metastatic gastric cancer (MGC) treated with anti-PD-1 and chemotherapy. Methods: Patients with MGC treated with an anti-PD-1 therapy or chemotherapy were enrolled. This study was composed of two cohorts including 266 patients in the anti-PD-1-treated
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Unveiling prostatic inflammation to optimize management of lower urinary tract symptoms: a discussion with experts Biomark. Med. (IF 2.2) Pub Date : 2023-11-16 Mauro Gacci, Cosimo De Nunzio, Stavros Gravas
Benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS) are common conditions in men, which increase in frequency and severity with age, and have a significant impact on quality of life. Chronic prostatic inflammation is increasingly being recognized as a key component of BPO. This may lead to new targets for the management of BPO/LUTS. This podcast is based on presentations
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Detection of infections by computerized capture of peaks in longitudinally measured C-reactive protein levels Biomark. Med. (IF 2.2) Pub Date : 2023-11-14 Olav Sivertsen Garvik, Pedro Póvoa, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Henrik Frederiksen, Ming Chen, Ram Benny Dessau, John Eugenio Coia, Jens Kjølseth Møller, Kim Oren Gradel
We developed four algorithms for the automatic capture of C-reactive protein (CRP) peaks in 296 adult patients with acute myeloid leukemia who had bloodstream infection (BSI) episodes, negative blood cultures (BCs) or possible infections where no BCs were performed. The algorithms detected CRP peaks for 418–446 of the 586 documented BSI episodes (71.3–76.1%) and 2714–3118 of the 4382 negative BCs (61
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Longitudinal change in CDC42 in psoriasis: correlation with disease activity and treatment response Biomark. Med. (IF 2.2) Pub Date : 2023-11-07 Bing Xu, Leiqiang Fan, Qiaoli Liu, Bin Guo, Tao Yang, Yanfeng Zhang
Objective: To investigate longitudinal CDC42 change and its correlation with disease activity and treatment response in patients with psoriasis. Methods: This prospective study detected serum CDC42 at months (M) 0, M1, M3 and M6 in 150 patients with psoriasis with current initiation of topical therapy/phototherapy/systemic therapy. Results: CDC42 was positively related to systemic biologic treatment
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Recent progress in biomarker-based diagnostics of Helicobacter pylori, gastric cancer-causing bacteria Biomark. Med. (IF 2.2) Pub Date : 2023-11-07 Kirti Saxena, Akanksha Deshwal, Ramesh Namdeo Pudake, Utkarsh Jain, Ravi Mani Tripathi
The progression of any disease and its outcomes depend on the complicated interaction between pathogens, host and environmental factors. Thus, complete knowledge of bacterial toxins involved in pathogenesis is necessary to develop diagnostic methods and alternative therapies, including vaccines. This review summarizes recently employed biomarkers to diagnose the presence of Helicobacter pylori bacteria
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A novel cuproptosis-related lncRNA prognostic signature in thyroid cancer Biomark. Med. (IF 2.2) Pub Date : 2023-11-07 Lujia Liu, Jie Xu, Xifeng Sun, Haitao Zheng
Aims: We aimed to investigate the value of cuproptosis-related lncRNA in screening out high-risk thyroid cancer patients. Materials & methods: RNA sequencing data of thyroid cancer were obtained from The Cancer Genome Atlas. A cuproptosis-related lncRNA signature was constructed by using Cox regression. Results: Four cuproptosis-related lncRNAs were used to construct a survival prognosis model for
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Diagnostic value of circRNA in coronary heart disease: a meta-analysis. Biomark. Med. (IF 2.2) Pub Date : 2023-11-07 Ming-Zhu Li,Jia-Nan Zhang,Fei Ren,De-Lu Yin,Xin-Hua Zhao,Kun Liu
Aim: Studies have indicated that circRNAs have diagnostic value for coronary heart disease (CHD), but the efficacy varies greatly; therefore, a meta-analysis was conducted to assess the diagnostic value of circRNAs in CHD Materials & methods: 16 studies with 3962 subjects (2239 cases and 1723 controls) were included by searching PubMed, Web of Science and MEDLINE. The pooled sensitivity and specificity
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Feasibility evaluation of hsa_circ_0005480 as an auxiliary diagnostic and prognostic indicator for gastric cancer Biomark. Med. (IF 2.2) Pub Date : 2023-10-30 Jiajia Yu, Kang Lu, Huifang Huang, Junyi Wang, Qian Yang
Aim: To explore the potential role of hsa_circ_0005480 as a marker for gastric cancer (GC). Methods: GSE83521, GSE93541 and GSE131414 were combined to screen the most potential circRNAs in GC. The expression of hsa_circ_0005480 was verified in clinical plasma samples and its diagnostic performance was evaluated by receiver operating characteristic (ROC) curve. Results: Hsa_circ_0005480 was upregulated
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EVI2B may be a novel prognostic marker for lung adenocarcinoma Biomark. Med. (IF 2.2) Pub Date : 2023-10-16 Yin Fu, Junming He, Jian Chen, Jiangwei Hu, Wei Guan, Guoliang Lou
Objective: This study intended to unravel the relationship of EVI2B expression with lung adenocarcinoma (LUAD). Methods: TIMER1.0, Gene Expression Profiling Interactive Analysis and Human Protein Atlas databases, as well as the University of Alabama at Birmingham Cancer website, were used to analyze the expression of EVI2B and its relationship with clinical features. The relationship between survival
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KRT15 in early breast cancer screening and correlation with HER2 positivity, pathological grade and N stage Biomark. Med. (IF 2.2) Pub Date : 2023-10-10 Zijing Zhang, Hongying Wang, Yiting Jin, Jian Zhou, Chengyu Chu, Feng Tang, Liping Zou, Qiang Zou
Objective: This study was designed to explore KRT15 dysregulation and its correlation with clinical characteristics among ductal carcinoma in situ (DCIS), DCIS with microinvasion (DCIS-MI) and invasive breast cancer (IBC) patients. Methods: KRT15 from lesion samples of 50 DCIS patients, 48 DCIS-MI patients and 50 IBC patients was detected by immunohistochemistry. Results:KRT15 discriminated IBC patients
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Value of increased CRP/albumin ratio in predicting embolic events in patients with infective endocarditis Biomark. Med. (IF 2.2) Pub Date : 2023-10-09 Şaban Kelesoglu, Sinan Inci, Murat Gul, Ramazan Ozan, Ismail Düzgün, Aydın Tuncay, Halil Aktaş, Deniz Elcik, Nihat Kalay
Background: The CRP/albumin ratio (CAR), a new inflammatory marker, is associated with adverse outcomes in various cardiovascular diseases. We evaluated the effectiveness of CAR in predicting embolic events in patients diagnosed with infective endocarditis (IE). Methods: A total of 145 patients with IE were included in the study and categorized into two groups according to the presence of embolic events
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Peptidylglycine α-amidating monooxygenase and adrenomedullin measurement in patients with hepatic cirrhosis Biomark. Med. (IF 2.2) Pub Date : 2023-10-09 Jens P Goetze, Andrei Voiosu, Signe Wiese, Janin Schulte, Paul Kaufmann, Andreas Bergmann, Emil D Bartels, Søren Møller
Background: Peptidylglycine α-amidating mono-oxygenase (PAM) is an enzyme involved in the maturation of regulatory peptides. Here we examined PAM activity and adrenomedullin (bio-ADM) concentrations in patients with hepatic cirrhosis and determined net changes across the liver, kidneys and leg. Materials & methods: A total of 48 patients with hepatic cirrhosis and 16 control subjects were included
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Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis Biomark. Med. (IF 2.2) Pub Date : 2023-10-09 Yangjing Teng, Xinyi Fu, Qin Zhang, Feiyang Wang, Yan Liu, Zhenhong Zou
Background: Cancer is one of the top causes of mortality worldwide. The matrix metalloproteinase MMP12 is highly expressed in some cancers, but there is a lack of meta-analyses proving the correlation between MMP12 and cancer. Materials & methods: A literature search was performed using Web of Science, PubMed and other databases. Quantitative meta-analysis of the data was carried out. The Cancer Genome
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Predictive epidemiological, clinical and laboratory parameters in the diagnosis of Crimean–Congo hemorrhagic fever Biomark. Med. (IF 2.2) Pub Date : 2023-10-04 Türkkan Ö Kaygusuz, Ayşe S Tartar, Şafak Ö Balin, Ayhan Akbulut, Kutbeddin Demirdağ
Background: The aim of this study is to determine predictive parameters that can be used in the differential diagnosis of Crimean–Congo Hemorrhagic Fever (CCHF) and other diseases with similar clinical and laboratory findings. Materials & methods: In this study, epidemiological, clinical and laboratory parameters of 107 CCHF-positive and 71 CCHF-negative patients were compared. Results: Alanine amino
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US FDA public meeting: identification of concepts and terminology for multicomponent biomarkers Biomark. Med. (IF 2.2) Pub Date : 2023-09-15 Abena S Agyeman, Abbas Bandukwala, Khaled Bouri, Jessica Hawes, Daniel M Krainak, Samir Lababidi, William B Mattes, Elena V Mishina, Phillip Turfle, Sue-Jane Wang, Theresa Thekkudan
The US FDA convened a virtual public workshop with the goals of obtaining feedback on the terminology needed for effective communication of multicomponent biomarkers and discussing the diverse use of biomarkers observed across the FDA and identifying common issues. The workshop included keynote and background presentations addressing the stated goals, followed by a series of case studies highlighting
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CD39 (ENTPD1) in tumors: a potential therapeutic target and prognostic biomarker Biomark. Med. (IF 2.2) Pub Date : 2023-09-15 Cuicui Li, Litian Zhang, Qiqi Jin, Haoyun Jiang, Chongyang Wu
As a regulator of the dynamic balance between immune-activated extracellular ATP and immunosuppressive adenosine, CD39 ectonucleotidase impairs the ability of immune cells to exert anticancer immunity and plays an important role in the immune escape of tumor cells within the tumor microenvironment. In addition, CD39 has been studied in cancer patients to evaluate the prognosis, the efficacy of immunotherapy
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NT-proBNP/urine hepcidin-25 ratio and cardiorenal syndrome type 1 in patients with severe symptomatic aortic stenosis Biomark. Med. (IF 2.2) Pub Date : 2023-09-07 Jonathan Nübel, Meike Hoffmeister, Oliver Labrenz, Kerstin Jost, Stefanie Oess, Michael Hauptmann, Julika Schön, Georg Fritz, Michael Haase, Christian Butter, Anja Haase-Fielitz
Background: This study aimed to determine whether novel and conventional cardiorenal biomarkers in patients before transcatheter aortic valve implantation may be associated with cardiorenal syndrome (CRS) type 1. Methods: Serum NT-proBNP and urine biomarkers (hepcidin-25, NGAL, IL-6) were measured before and 24 h after transcatheter aortic valve implantation. Results: 16/95 patients had CRS type 1
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Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma. Biomark. Med. (IF 2.2) Pub Date : 2023-09-01 Zuo Wang,Hang Yuan,Xiong Zhu,Jinxia Wang,Wenbo Xiu,Yang Chen,Gao Zhang,Jing Fu,Kun Peng,An Li,Donghua Liu,Xijing Huang,Chong He,Fang Lu
Objective: The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. Methods: A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. Results: The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g;
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A comprehensive review of novel biomarkers in the diagnosis of intrahepatic cholestasis of pregnancy Biomark. Med. (IF 2.2) Pub Date : 2023-08-31 Weici Liu, Lingyan Chen, Wenxiang Wang, Zhiran Yue, Jingyang Li, Mengjing Tan, Ying Gu, Ru Zhu, Yan Zhang
Intrahepatic cholestasis of pregnancy (ICP) is a disease specific to pregnancy, featuring maternal itching and elevated serum bile acid levels. It leads to a series of adverse pregnancy outcomes as well as increased fetal mortality. Routine biochemical markers fail to fulfill the tremendous clinical requirements, thereby novel effective biomarkers are urgently desired. In our review, the potential
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Differential absolute plasma IL-6 concentrations between two immunoassay platforms in intensive care unit patients with COVID-19 Biomark. Med. (IF 2.2) Pub Date : 2023-08-31 Pavan K Bhatraju, Eric D Morrell, Nicholas G O'Connor, Audrey Choi, Michael Fitzpatrick, Craig H Smith, Mark M Wurfel, Wayne Conrad Liles
Objectives: Explore whether plasma IL-6 levels are similar across biomarker platforms and association with COVID-19 clinical outcomes. Methods: Plasma IL-6 concentrations were measured on 191 COVID-19 patients using the Roche Elecsys IL-6 assay and the Meso Scale Discovery assay. Results: Correlation of IL-6 levels between platforms was high (r = 0.87; 95% CI: 0.82–0.89); however, agreement was low