-
Focus on cardiac troponin complex: From gene expression to cardiomyopathy Genes Dis. (IF 6.8) Pub Date : 2024-03-11 Rosetta Ragusa, Chiara Caselli
The cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin filament during diastole; and cTnT, which has multiple roles in sarcomere, such as promoting the link between the cTnI-cTnC complex and tropomyosin within
-
Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs Genes Dis. (IF 6.8) Pub Date : 2024-03-09 Xia Kang, Kun Zhao, Zhu Huang, So-ichiro Fukada, Xiao-wei Qi, Hongming Miao
Pdgfrα stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the
-
Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Bin Du, Zijie Deng, Kang Chen, Zhangzhong Yang, Junfen Wei, Liuyao Zhou, Jie Meng, Ying Cheng, Xin Tian, Qingzhang Tuo, Peng Lei
Programmed cell death contributes to neurological damage in ischemic stroke, especially during the reperfusion stage. Several cell death pathways have been tested preclinically and clinically, including ferroptosis, necroptosis, and apoptosis. However, the sequence and complex interplay between cell death pathways during ischemia/reperfusion remains under investigation. Here, we unbiasedly investigated
-
mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Jingxuan Shi, Xinze Liu, Yuanyuan Jiao, Jingwei Tian, Jiaqi An, Guming Zou, Li Zhuo
Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance renal prognosis in affected patients. The mammalian target of rapamycin (mTOR), a serine/threonine protease
-
Identification of ferroptosis/autophagy-related genes and potential underlying mechanisms involved in the effect of BMSC senescence on the osteogenic differentiation of aging BMSCs Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Kai Chen, Huaqiang Tao, Haixiang Xiao, Miao Chu, Pengfei Zhu, Shujun Lv, Lixin Huang, Dechun Geng
-
Time-series transcriptome analysis mapping pulmonary immune checkpoint atlas of experimental silicosis Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Youliang Zhao, Yuanmeng Qi, Meixiu Duan, Changfu Hao, Wu Yao
-
EBF1 expressed in the dermal papilla regulates hair type and length Genes Dis. (IF 6.8) Pub Date : 2024-03-07 Hongzhi Song, Lei Zhang, Wei-qi Zhong, Eve Qian Chen, Xi-Xi Qiu, Zi-Ling Tang, Xin-Hua Liao
-
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target Genes Dis. (IF 6.8) Pub Date : 2024-03-05 Kun Fang, Suxiao Jiang, Zhengjie Xu, Meng Luo, Changsheng Yan
-
Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment Genes Dis. (IF 6.8) Pub Date : 2024-03-05 Weijin Qiu, Qian Zhang, Jing Liu, Xueling He, Guangqing Cheng, Jiayun Chen, Yunmeng Bai, Piao Luo, Ping Gong, Fei Shi, Jigang Wang
-
Heterogeneity of anoikis in triple-negative breast cancer subtyping and therapeutic implications Genes Dis. (IF 6.8) Pub Date : 2024-03-04 Kun Fang, Suxiao Jiang, Zhengjie Xu, Meng Luo, Changsheng Yan
-
CircAkap7: A novel circular RNA with a role in doxorubicin-induced cardiotoxicity Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Jiaqin Liu, Sa Liu, Xiangyun Li, Shanshan Wei, Taoli Sun, Ning Xie, Bikui Zhang, Wenqun Li
-
Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Jianxiong Xu, Jinxuan Wang, Hongping Zhang, Yidan Chen, Xiaojuan Zhang, Ying Zhang, Ming Xie, Jun Xiao, Juhui Qiu, Guixue Wang
The clearance of apoptotic cell debris, containing professional phagocytosis and non-professional phagocytosis, is essential for maintaining the homeostasis of healthy tissues. Here, we discovered that endothelial cells could engulf apoptotic cell debris in atherosclerotic plaque. Single-cell RNA sequencing (RNA-seq) has revealed a unique endothelial cell subpopulation in atherosclerosis, which was
-
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu
Although cell-cycle arrest, senescence, and apoptosis are well accepted as the classic barriers in tumorigenesis, recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer development. It is well accepted that ferroptosis, an iron-dependent programmed cell death, acts as a new type of tumor suppression mechanism tightly linked with numerous metabolic pathways
-
Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Dingyuan Tian, Jie Li, Xiaoyue Lai, Qingyuan Yang, Zhihui Zhang, Fang Deng
Coronary microvascular dysfunction (CMD) is a clinical syndrome of myocardial ischemia caused by structural and/or functional abnormalities of pre-coronary arterioles and arterioles. While genetics and other factors play a role in CMD etiology, the key pathogenic mechanism remains unclear. Currently, the diagnostic procedure for CMD is still cumbersome, and there is a lack of effective targeted interventions
-
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Cheng Qiu, Lin Cheng, Derun Di, Ziqian Xiang, Congyu Wang, Jinghang Li, Yinuo Xiong, Manyu Li, Jingwei Liu, Jian Zhou, Tianyi Liu, Xinyu Wang, Dan Luo, Xiaoxiong Wang, Shangye Li, Hui Wang, Xia Wang, Yunpeng Zhao, Xinyu Liu, Lianlei Wang
Intervertebral disc degeneration (IDD) is a common chronic inflammatory degenerative disease that causes lower back pain. However, the underlying mechanisms of IDD remain unclear. Ferroptosis suppressor protein 1 (FSP1) is a newly identified suppressor for ferroptosis. This study aims to investigate the role of FSP1 in IDD. Nucleus pulposus (NP) tissues in humans were collected and NP cells from rats
-
Post-transcriptional regulation of DEAD-Box RNA helicases in hematopoietic malignancies Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events, including RNA alternative splicing, RNA localization, RNA degradation, and storage. Notably, post-transcriptional
-
Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling Genes Dis. (IF 6.8) Pub Date : 2024-02-24 Daofu Zeng, Muhammad Umar, Zhenglin Zhu, Haobo Pan, William W. Lu, Guozhi Xiao, Yan Chen, Liping Tong, Di Chen
Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development
-
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization Genes Dis. (IF 6.8) Pub Date : 2024-02-15 Huijun Qiu, Jiang Liu, Jingyi You, Ou Zhou, Chang Hao, Yi Shu, Deyu Ma, Wenjing Zou, Linghuan Zhang, Enmei Liu, Zhengxiu Luo, Luo Ren, Gang Geng, Lin Zou, Danyi Peng, Zhou Fu
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling molecule sphingosine-1-phosphate, has been shown to mediate the development of pulmonary fibrosis, although the underlying mechanism is not fully understood. Here, we found increased expression of S1pr3 in the lung during the process of
-
Establishment of a mouse model of respiratory mycoplasma challenged intranasally combined intraperitoneally eliciting chronic inflammation and lung consolidation Genes Dis. (IF 6.8) Pub Date : 2024-02-09 Xing Xie, Yuan Gan, Maoda Pang, Lei Zhang, Fei Hao, Yanna Wei, Yi Chen, Rong Chen, Zhenzhen Zhang, Qingyun Xie, Daesub Song, Guoqing Shao, Maojun Liu, Qiyan Xiong, Zhixin Feng
-
Chimeric RNA landscape in the placenta: A transcriptomic analysis revealing novel diagnostic biomarkers for preeclampsia Genes Dis. (IF 6.8) Pub Date : 2024-02-09 Jingjing Xu, Xinrui Shi, Shitong Lin, Sandeep Singh, Samuel Haddox, Christopher Phung, Tommy Manley, Ningxi Huang, Peng Wu, Hui Li
Chimeric RNAs, hybrid transcripts containing exons from two originally separate genes, have been extensively studied in various cancer types and non-cancerous tissues. The hybrid transcripts can arise through different mechanisms, such as chromosomal rearrangements, trans-splicing events, or read-through transcription. The investigation into chimeric RNA landscape across various cancer types as well
-
Research progress and the prospect of using single-cell sequencing technology to explore the characteristics of the tumor microenvironment Genes Dis. (IF 6.8) Pub Date : 2024-02-03 Wenyige Zhang, Xue Zhang, Feifei Teng, Qijun Yang, Jiayi Wang, Bing Sun, Jie Liu, Jingyan Zhang, Xiaomeng Sun, Hanqing Zhao, Yuxuan Xie, Kaili Liao, Xiaozhong Wang
-
Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA Genes Dis. (IF 6.8) Pub Date : 2024-02-03 Jihua Ren, Shengtao Cheng, Fang Ren, Huiying Gu, Daiqing Wu, Xinyan Yao, Ming Tan, Ailong Huang, Juan Chen
Human hepatitis B virus (HBV) infection is the major cause of acute and chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma. Although the application of prophylactic vaccination programs has successfully prevented the trend of increasing HBV infection prevalence, the number of HBV-infected people remains very high. Approved therapeutic management efficiently suppresses viral replication;
-
Functional impact of the head domain variants of DES (Desmin) on filament assembly Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Sabrina Voß, Volker Walhorn, Stephanie Holler, Anna Gärtner, Greta Pohl, Jens Tiesmeier, Jan Gummert, Dario Anselmetti, Hendrik Milting, Andreas Brodehl
Abstract not available
-
Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Yulan Huang, Yuan Gao, Zhenghong Lin, Hongming Miao
The tumor microenvironment is a complex environment comprising tumor cells, non-tumor cells, and other critical non-cellular components. Some studies about tumor microenvironment have recently achieved remarkable progress in tumor treatment. As a substantial part of post-translational protein modification, ubiquitination is a crucial player in maintaining protein stability in cell signaling, cell growth
-
Mutations in GTPBP3 cause aberrant mitochondrial respiration associated with combined oxidative phosphorylation deficiency 23 Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Qianqian Li, Yang Yang, Ranran Li, Chenguang Yu, Kaidi Ren, Yin Feng, Xing Chen, Yi Luan, Xiangdong Kong
Abstract not available
-
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Changyuan Huang, Bin Zeng, Bo Zhou, Guanming Chen, Qi Zhang, Wenhong Hou, Guozhi Xiao, Li Duan, Ni Hong, Wenfei Jin
Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders our understanding of the pathogenesis of osteoarthritis (OA). Here, we constructed a single-cell transcriptomic atlas of chondrocytes in healthy cartilage and identified nine chondrocyte subsets including homeostatic chondrocytes
-
Novel virulence-related genes that contribute to clinical infections of Salmonella enteritidis Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Bill Kwan-wai Chan, Ruichao Li, Edward Wai-chi Chan, Kwok-yin Wong, Sheng Chen
Abstract not available
-
EGCG alleviates vascular calcification via the MAPK/JunB signaling pathway Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Tiantian Li, Fei Fang, Hongmei Yin, Zhen Zhang, Xiangxiu Wang, Erxiang Wang, Hongchi Yu, Yang Shen, Guixue Wang, Weihong He, Xiaoheng Liu
Abstract not available
-
Single-cell sequencing revealed the microglia-activated cell distribution in gray matter heterotopia Genes Dis. (IF 6.8) Pub Date : 2024-02-02 Penghu Wei, Chunhao Shen, Jinkun Xu, Quanlei Liu, Yihe Wang, Xiaotong Fan, Yongzhi Shan, Guoguang Zhao
Abstract not available
-
MMP-9 deficiency accelerates the progress of periodontitis Genes Dis. (IF 6.8) Pub Date : 2024-01-28 Chun-Yan Wan, Yixin Yin, Xiaoyan Li, Meng Meng Liu, Graham Goldman, Li-an Wu, Feng Wang, Dao-Shu Luo, Zhuo Chen, Wen-An Xu, Stephen Chen, Mary MacDougall, Merry L. Lindsey, Zhi Chen, Shuo Chen
Abstract not available
-
Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α Genes Dis. (IF 6.8) Pub Date : 2024-01-28 Guangfei Li, Aifei Wang, Wei Tang, Wenyu Fu, Qingyun Tian, Jinlong Jian, Michal Lata, Aubryanna Hettinghouse, Yuanjing Ding, Jianlu Wei, Xiangli Zhao, Mingyong Wang, Qirong Dong, Chuanju Liu, Youjia Xu
Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis. However, the underlying mechanism is still not completely understood. In this study, progranulin (PGRN) was isolated as a key regulator of bone mineral density in postmenopausal women through high throughput proteomics screening. In addition, PGRN-deficient mice exhibited significantly lower bone mass than their
-
Single-cell sequencing reveals the immune microenvironment associated with gastric cancer Genes Dis. (IF 6.8) Pub Date : 2024-01-26 Guoquan Huang, Cheng Yuan, Chao Zhang, Fuyu Yang, Yong Tan, Defei Chen, Hui Li, Kun Qian
Abstract not available
-
Exploring biomarkers of MAPK pathway co-expression in lung adenocarcinoma and their functions based on machine learning algorithms and single-cell analysis Genes Dis. (IF 6.8) Pub Date : 2024-01-26 Mingkai Lin, Ruoyi Zheng, Peixian Liang, Jiayang Huang, Xintong Ke, Wenjing Zhang, Pei Shang
Abstract not available
-
CircDONSON regulates the proliferation, invasion and migration of non-small cell lung cancer cells through the MAPK signaling pathway Genes Dis. (IF 6.8) Pub Date : 2024-01-23 Shichao Zhang, Zhenguo Zeng, Feng Qiu, Xiaolei Li, Xinping Xu
Abstract not available
-
To cleave or not and how? The DNA exonucleases and endonucleases in immunity Genes Dis. (IF 6.8) Pub Date : 2024-01-24 Mingjun Lu, Jinghong Wu, Qing Gao, Renjing Jin, Changming An, Teng Ma
DNA exonucleases and endonucleases are key executors of the genome during many physiological processes. They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA, triggering the activation of the innate immune pathways such as cGAS-STING-IFN, and enabling the body to produce anti-viral or anti-tumor immune responses. This is of great significance for maintaining the stability
-
CDK9 inhibitor elicits APC through a synthetic lethal effect in colorectal cancer cells Genes Dis. (IF 6.8) Pub Date : 2024-01-24 Tingming Liang, Lulu Luo, Xinru Xu, Yajing Du, Xinbing Yang, Jiahui Xiao, Xiaoyan Huang, Huiying Yang, Siyu Wang, Li Guo
Abstract not available
-
Histone deacetylases: Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis Genes Dis. (IF 6.8) Pub Date : 2024-01-22 Hanyi Yang, Kai Guo, Peng Ding, Jiayi Ning, Yimeng Zhang, Yuanyong Wang, Zhaoyang Wang, Guanglin Liu, Changjian Shao, Minghong Pan, Zhiqiang Ma, Xiaolong Yan, Jing Han
Histone deacetylases (HDACs) are proteases that play a key role in chromosome structural modification and gene expression regulation, and the involvement of HDACs in cancer, the nervous system, and the metabolic and immune system has been well reviewed. Our understanding of the function of HDACs in the vascular system has recently progressed, and a significant variety of HDAC inhibitors have been shown
-
Corrigendum to ‘Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics’ [Genes & Diseases10 (2023) 1367–1401] Genes Dis. (IF 6.8) Pub Date : 2024-01-20 Uttpal Anand, Abhijit Dey, Arvind K. Singh Chandel, Rupa Sanyal, Amarnath Mishra, Devendra Kumar Pandey, Valentina De Falco, Arun Upadhyay, Ramesh Kandimalla, Anupama Chaudhary, Jaspreet Kaur Dhanjal, Saikat Dewanjee, Jayalakshmi Vallamkondu, José M. Pérez de la Lastra
Abstract not available
-
Identification of ferroptosis-associated tumor antigens as the potential targets to prevent head and neck squamous cell carcinoma Genes Dis. (IF 6.8) Pub Date : 2024-01-19 Qiming Zhai, Zhiwei Wang, Han Tang, Shanshan Hu, Meihua Chen, Ping Ji
Head and neck squamous cell carcinoma (HNSC) represents nearly 90% of all head and neck tumors. The current treatment modality for HNSC patients primarily involves surgical intervention and radiotherapy, but its therapeutic efficacy remains limited. The mRNA vaccine based on tumor antigens seems promising for cancer treatment. Ferroptosis, a novel form of cell death, is linked to tumor progression
-
IGF2BP1 promotes multiple myeloma with chromosome 1q gain via increasing CDC5L expression in an m6A-dependent manner Genes Dis. (IF 6.8) Pub Date : 2024-01-17 Jiadai Xu, Yawen Wang, Liang Ren, Panpan Li, Peng Liu
Multiple myeloma (MM) patients with chromosome 1q gain (1q+) are clinically and biologically heterogeneous. The underlying molecular mechanisms are still under investigation, while the identification of targets for effective therapy of this subgroup of MM patients is urgently needed. We aimed to investigate the clinical significance and the regulatory mechanisms of insulin-like growth factor 2 messenger
-
Low CXCR6 expression drives extracellular matrix remodeling and enhances cell proliferation in OSCC Genes Dis. (IF 6.8) Pub Date : 2024-01-17 Yang Xun, Hua Yang, Yilong Ai, Honglin Li, Hua You, Fang Liu
Abstract not available
-
Mutational and transcriptional profiling of cuproptosis-associated genes in amyotrophic lateral sclerosis Genes Dis. (IF 6.8) Pub Date : 2024-01-14 He Di, Xilu Wang, Meng Hao, Dongchao Shen, Xunzhe Yang, Mingsheng Liu, Yi Li, Jiucun Wang, Liying Cui
Abstract not available
-
Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice Genes Dis. (IF 6.8) Pub Date : 2024-01-12 Liying Shan, Xiaoxia Liao, Xiaoli Yang, Endong Zhu, Hairui Yuan, Jie Zhou, Xiaoxia Li, Baoli Wang
Naked cuticle homolog 2 (NKD2) has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor. The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully understood. In this study, we identified the up-regulation of NKD2 during osteoblast and adipocyte differentiation. Functional experiments revealed that NKD2 stimulated osteoblast differentiation
-
Fact or fiction — Exploring resident mesenchymal stem cells in abdominal aortic aneurysm from multiple perspectives Genes Dis. (IF 6.8) Pub Date : 2024-01-14 Shikai Shen, Yanshuo Han, Qingwei Gang, Mingyu Liu, Yao Qi, Jian Zhang
Abstract not available
-
Helicobacter pylori mediated niche environment aberrations promote the progression of gastric cancer Genes Dis. (IF 6.8) Pub Date : 2024-01-06 Teng Yan, Hang Sun, Yuhui Liao, Jiajian Zhou
Abstract not available
-
In situ transcriptomic analysis of spermatocytes in non-obstructive azoospermia reveals senescence-like states in arrested spermatocytes Genes Dis. (IF 6.8) Pub Date : 2024-01-03 Zhongqin Wu, Xiaolong Wu, Zeqian Xu, Yixin Liu, Ziyi Zhu, Xinhui Li, Daniel M. Czajkowsky, Fei Sun, Yan Guo, Zhifeng Shao
Abstract not available
-
Integrative network analysis identifies pivotal host genes and pathways for SARS-CoV-2 infection Genes Dis. (IF 6.8) Pub Date : 2024-01-03 Gao Chen, Li Li, Ruiqi Wang, Bin Liu, Zhiwen Cao, Ning Zhao, Yong Tan, Xiaojuan He, Jing Zhao, Cheng Lu
Abstract not available
-
PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis Genes Dis. (IF 6.8) Pub Date : 2024-01-03 Yu Tian, Yufan Wang, Qing Tian, Guiping Cheng, Li-quan Zhou
Abstract not available
-
Recent advances in methylation modifications of microRNA Genes Dis. (IF 6.8) Pub Date : 2023-12-23 Ning Su, Xiaohang Yu, Ming Duan, Ning Shi
microRNAs (miRNAs) are short single-stranded non-coding RNAs between 21 and 25 nt in length in eukaryotic organisms, which control post-transcriptional gene expression. Through complementary base pairing, miRNAs generally bind to their target messenger RNAs and repress protein production by destabilizing the messenger RNA and translational silencing. They regulate almost all life activities, such as
-
Extrachromosomal circular DNA and their roles in cancer progression Genes Dis. (IF 6.8) Pub Date : 2023-12-22 Siqi Zheng, Yunong Li, Lin Wang, Qian Wei, Minjie Wei, Tao Yu, Lin Zhao
Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma. Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments through complex and interrelated regulatory mechanisms. The unique structure and genetic properties of eccDNA
-
Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression Genes Dis. (IF 6.8) Pub Date : 2023-12-22 Lixin Liang, Tian Cai, Xiaojia Li, Jianhong An, Sen Yu, Yang Zhang, Fengjie Guo, Fang Wei, Jie He, Keping Xie, Tingting Jiang
Transcriptional factor Forkhead box M1 (FOXM1) plays an important role in pancreatic ductal adenocarcinoma (PDAC) development and progression. The molecular mechanisms underlying its dysregulation remain unclear. We identified and functionally validated the microRNAs (miRNAs) that critically regulate FOXM1 expression in PDAC. The expression levels of miRNA-23a (miR-23a-3p and -5p) were altered in PDAC
-
The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells Genes Dis. (IF 6.8) Pub Date : 2023-12-19 Jin Zhang, Lingling Tong, Yuchen Liu, Xiang Li, Jiayi Wang, Ruoxin Lin, Ziyu Zhou, Yunbing Chen, Yanxi Chen, Yirong Liu, Di Chen
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m6A modification is regulated by m6A writers, erasers, and readers. Emerging evidence suggests that m6A modification plays essential roles in modulating the cell fate transition
-
Constitutive androstane receptor: A tumor suppressor and a biomarker marker for favorable prognosis of liver diseases Genes Dis. (IF 6.8) Pub Date : 2023-12-19 Sarah Da Won Bae, Romario Nguyen, Lawrence Yuen, Vincent Lam, Jacob George, Liang Qiao
Abstract not available
-
CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency Genes Dis. (IF 6.8) Pub Date : 2023-12-19 Yue Ding, Zheng Ye, Bo Ding, Songwei Feng, Furong Du, Xuejiao Ma, Xiaoxuan Wang, Yang Shen
Abstract not available
-
Identification of immune cell infiltration pattern in diabetic nephropathy Genes Dis. (IF 6.8) Pub Date : 2023-12-17 Yongguang Liu, Xiaoyou Liu, Ding Liu, Song Zhou, Jie Zhang, Jianmin Hu, Guorong Liao, Jun Liao, Zefeng Guo, Yuzhu Li, Siqiang Yang, Shichao Li, Hua Chen, Ying Guo, Min Li, Lipei Fan, Liuyang Li, Ming Zhao
Abstract not available
-
Biallelic inactivation of SDHA results in comorbidity of pediatric recurrent neuroblastoma and gastric stromal tumor Genes Dis. (IF 6.8) Pub Date : 2023-12-15 Yang Shen, Shixuan Zhang, Wen Zhao, Libing Fu, Li Zhang, Chan Hon Chui, Ruolan Guo, Yan Su, Dayan Sun, Huanmin Wang
Abstract not available
-
Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia Genes Dis. (IF 6.8) Pub Date : 2023-12-13 Fei Ao, Fan Chen, Minhong Lv, Yuming Cao, Jinfeng Xu, Jingbo Xu, Anskar Yu-Hung Leung, Qiwen Yuan, Li Wang, Bailiang He
Abstract not available
-
The efficacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial Genes Dis. (IF 6.8) Pub Date : 2023-12-13 Honglei Yin, Zhuxin Sui, Yutong Wang, Dechen Liu, Qinglu Wang, Yanchao Wang, Lei Sun, Jinfeng Li, Zhen Li, Yue Liu, Shang Guo, Wenwen Wang, Hongtao Yin, Ping Liu, Kezhong Zhang, Huaibo Zhang, Yajun Liu, Yanqiu Liu, Qiqi Zhou, Dianfang Wei, Yunliang Wang
Abstract not available
-
RNA binding motif protein 43 (RBM43) Suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability Genes Dis. (IF 6.8) Pub Date : 2023-12-14 Yao Liu, Huan Feng, Qi Zhao, Xiao Liang, Ying Wang, Shuai Xiao, Suqin Shen, Jiaxue Wu
Abstract not available
-
Evolutionary characteristics, biochemical structure, functions, and clinical impact of MSTN gene Genes Dis. (IF 6.8) Pub Date : 2023-12-12 Rui Zhang, Yunpeng Wu, Tianqi Sun, Zhengxing Lian, Jingqing Chen, Yefeng Qiu
Abstract not available