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The Relationship between Choroidal Vascular Index and Non-Invasive Ultrasonographic Atherosclerosis Predictors Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-11 Muhammet Fatih Bayraktar, Güvenç Toprak (FEBO), Yunus Alkan (FEBO)
This study explores the intricate connections between choroidal vascular index (CVI) and non-invasive ultrasonographic atherosclerosis predictors, shedding light on the potential links between ocular vascular dynamics and systemic cardiovascular health. We conducted a cross-sectional analysis of 81 participants, assessing CVI, intima-media thickness (IMT), extra-media thickness (EMT), and the PATIMA
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Comparison of 5-ALA-PDT and LEEP of Cervical Squamous Intraepithelial Neoplasia (CIN2) with High-Risk Human Papillomavirus Infection In Childbearing Age Women: A non-randomized controlled polit study Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-11 Lili Wang, Xiaoli Liu, Junhua Zhang, Min Song, Hongli Liu, Ying Xu, Lihua Meng, Youzhong Zhang, Lin Jia
5-Aminolevulinic acid-mediated photodynamic therapy (5-ALA-PDT) is a possible minimally-invasive treatment for high-grade cervical intraepithelial neoplasia (HSIL). The present study was carried out to assess the effect of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in cervical squamous intraepithelial neoplasia (CIN2) combined with high-risk human papillomavirus (HR-HPV) infection
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Advances In Photodynamic Therapy of Pathologic Scar Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-08 Xing Li, Xin Wang, Tuo Shen, Jianxiang Xiong, Qimin Ma, Guanghua Guo, Feng Zhu
Pathologic scars include keloids and hypertrophic scars due to abnormal wound healing. Both cause symptoms of itching and pain; they also affect one's appearance and may even constrain movement. Such scars place a heavy burden on the individual's physical and mental health; moreover, treatment with surgery alone is highly likely to leave more scarring. Therefore, there is an urgent need for a treatment
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Preoperative Evaluation of White Cataracts with the Pentacam Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-07 Güvenç Toprak, Yunus Alkan, Abdullah Bayrak
To evaluate the use of the Pentacam to analyse the presence or absence of fluid pockets under the anterior capsule and their significance in terms of surgical management and prevention of complications. Abant İzzet Baysal University Hospital, Bolu, Turkey Randomized, masked, prospective design 60 patients with mature cataracts underwent standard phacoemulsification (Phaco) and intraocular lens (IOL)
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Optical coherence tomography biomarkers indicating visual enhancement in diabetic macular edema resolved through anti-VEGF therapy: OCT biomarkers in resolved DME Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-07 Pasquale Viggiano, Stela Vujosevic, Francesca Palumbo, Maria Oliva Grassi, Giacomo Boscia, Enrico Borrelli, Michele Reibaldi, Luigi Sborgia, Teresa Molfetta, Federica Evangelista, Giovanni Alessio, Francesco Boscia
to investigate the structural features and extended visual results in eyes affected by diabetic retinopathy (DR) and diabetic macular edema (DME) that have been successfully treated with anti-vascular endothelial growth factor (VEGF) therapy. Individuals (39 eyes of 39 patients) who had undergone long-term follow-up and demonstrated evidence of resolved DME after at least 2 years of follow-up following
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Successful Treatment of Bowen's Disease in the Nipple-areola Complex with a Combination of Photodynamic Therapy and Cryotherapy–A Case Report Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-07 Na Zhang, Xinru Chen, Hongping Ge, Xiaoli Zhai, Min Zhang, Meiyan Wang
Photodynamic therapy (PDT) is a non-invasive, effective treatment for superficial skin conditions, offering superior cosmetic outcomes compared with traditional therapies. Bowen's disease (BD) of the nipple-areola complex (NAC) is rare and thus, lacks a standardized treatment approach. This report details the case of a 48-year-old woman who was successfully treated for BD of the NAC using PDT. Over
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Home- vs clinic-based daylight photodynamic therapy with 5-aminolevulinic acid nanoemulsion (BF-200 ALA) for actinic keratosis: A randomized, single-blind, prospective study. Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-02 S. Saenz-Guirado, A Ayen-Rodriguez, M Galvez-Moreno, JP Velasco-Amador, JM Llamas-Molina, R Ruiz-Villaverde, A Molina-Leyva
Daylight photodynamic therapy (DL-PDT) has become one of the most effective treatments for the resolution of actinic keratosis (AK) of Olsen grade 1 and 2. Generally, PDT it is carried out in a clinic setting, which involves the patient's and their caregivers commuting to the hospital as well as a significant use of resources to carry it out within the clinic setting. To determine the efficacy and
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Laser light: Illuminating the path to enhanced periodontal care Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-02 Ankita Chhabrani, B.S Avinash, R. Sumukh Bharadwaj, Muskan Gupta
The utilisation of laser technology in the realm of periodontal care represents a significant advancement in clinical practice. This article delves into the historical context of laser therapy in medicine, from its inception in 1960 to its evolution into low-level laser therapy (LLLT). LLLT, often referred to as photobiomodulation (PBM), has garnered attention due to its potential to enhance periodontal
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Perifoveal retinal thickness changes after intravitreal aflibercept injection for choroidal neovascularization in age-related macular degeneration Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-02 Hakan BAYBORA
There has been some concern that anti-vascular growth factor treatment accelerates the development of macular atrophy in eyes with neovascular age-related macular degeneration. During the treatment with aflibercept, the thickness of choroid may decrease. This may lead to photoreceptor death. The rod cells are more susceptible to atrophic changes than cones during the disease. We aimed to find any thickness
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Development of a novel in vitro model for non-cavitated carious lesion formation reflecting carious lesion activity Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-02 Hee-Eun Kim
Oral biofilms are a critical component in dental caries formation However, current remineralization studies often overlook the impact of microbial factors. Therefore, a comprehensive clinically relevant assessment of caries is needed. This study aimed to develop a novel model capable of generating non-cavitated carious lesions that incorporates both mineral loss and microbial activity using quantitative
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Assessment of Diagnostic Accuracy and Reliability of Reveal Fluorescence Dental Loupes in Detecting Molar Incisor Hypomineralization in Children Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-01 Zuhair Al-Nerabieah, Muaaz AlKhouli, Mayssoon Dashash
Molar-Incisor Hypomineralization (MIH) poses challenges to accurate diagnosis, impacting children's oral health. Traditional methods exhibit limitations, necessitating innovative approaches. This study aimed to evaluate the reliability and diagnostic accuracy Reveal Fluorescence Dental Loupes (RFDLs) for the detection of MIH This cross-sectional study, adhering to STRAD guidelines, involved 38 healthy
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Hematoporphyrin monomethyl ether-mediated photodynamic therapy for acquired port-wine stain at lower extremity: Two case reports Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-03-01 Yawen Wang, Jun Xia, Zhao Wang, Dan Ye, Youbao Li, Die Hu, Dongqin Lei, Jun Zhou, Songmei Geng, Weihui Zeng, Jing Liu
Two cases of acquired port-wine stain (APWS) at lower extremity were treated with hematoporphyrin monomethyl ether (HMME) and 532 nm LED green light-mediated photodynamic therapy (HMME-PDT). No serious adverse reactions were observed during or post-treatment period. Five-month follow-up showed significant reduction of red patches after a single HMME-PDT treatment in both cases.
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Trends in Application of Fundus Fluorescein Angiography in Fundus Diseases during a Recent Ten-Year Period Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-29 Xiaoqiu Shen, Tingye Zhou, Zuhua Sun, Yan Zheng, Bing Lin, Ying Huang
To analyze the trends in the application of fundus fluorescein angiography (FFA) in fundus diseases over ten years. It was a retrospective study. Patients who underwent FFA examinations between Jan 2012 and Dec 2021 in Eye Hospital of Wenzhou Medical University were included, excluding infants. Data included the fundus disease and examination time of FFA. A total of 37,038 cases underwent FFA examinations
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Lesion segmentation using 3D scan and deep learning for the evaluation of facial portwine stain birthmarks Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-28 Cheng Ke, Yuanbo Huang, Jun Yang, Yunjie Zhang, Huiqi Zhan, Chunfa Wu, Mingye Bi, Zheng Huang
PWS patches of different color and shape were use to create 2D and 3D models. 3D images were acquired by 3D scanner to create corresponding texture maps. Deep learning automatic segmentation using different backbone networks was used to extract PWS lesion from texture mapping of 3D images.
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Phenotype of bilateral EYS-associated occult macular dystrophies based on multimodal imaging Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-28 Ming Yi, Rui Hua
The study aimed to confirm the multimodal imaging of occult macular dystrophy (OMD) with two heterozygous mutations, including an unreported heterozygous mutation. The study utilised several diagnostic methods, including Optos wide-field imaging, Bruch's membrane opening-minimum rim width (BMO-MRW), optical coherence tomography (OCT), multifocal electroretinogram (mf-ERG), fundus fluorescein angiography
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Enhancement of the effect of novel targeted 5-aminolevulinic acid conjugated bismuth oxide nanoparticles-based photodynamic therapy by simultaneous radiotherapy on KB cells Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-24 Fatemeh Akbarzadeh, Karim Khoshgard
Selective accumulation of photosensitizers into cancerous cells is one of the most important factors affecting photodynamic therapy (PDT) efficacy. 5-aminolevulinic acid (5-ALA) is the precursor of a strong photosensitizer, protoporphyrin-IX; but it has poor permeability into the cells. Folate receptors are overexpressed on the surface of many tumor cells. In the present study, folic acid (FA) and
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Clinical efficacy of photodynamic therapy of oral potentially malignant disorder Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-23 Yin Jing, Rong Shu, Tingting WU, Dongqi Liu, Xiao Luo, Jun Sun, Fangchun Chen
To investigate the clinical efficacy of aminovalerate hydrochloride photodynamic therapy (PDT) for oral potentially malignant disorder (OPMD),oral leukoplakia (OLK), along with identifying the influencing factors.Additionally, the study aims to detect the rates of recurrence and malignancy after PDT. 60 patients with OPMD who received PDT at our hospital from 2006 to 2021 were included in this study
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Photodynamic therapy with HiPorfin for cervical squamous intraepithelial lesion at childbearing age Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-23 Yu Liu, Ruifang Wu, Changzhong Li, Lihui Wei, Ruizhen Li
To evaluate the clinical efficacy and safety of HiPorfin® photodynamic therapy (PDT) in the treatment of young women at reproductive age with high-grade squamous intraepithelial lesion (HSIL) of the cervix. Prospective study of 41 patients aged 28.8 ± 4.6 years old with cervical intraepithelial neoplasia (CIN) Ⅱ-Ⅲ at Peking University Shenzhen Hospital from March 2019 to January 2023. HiPorfin® (2
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Does the quality of endoscopic equipment influence the recurrence rate after photodynamic diagnosis-assisted transurethral resection of bladder tumor? Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Ryunosuke Nakagawa, Takahiro Nohara, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Kazuyoshi Shigehara, Kouji Izumi, Atsushi Mizokami
Photodynamic diagnosis-assisted transurethral resection of bladder tumor (PDD-TURBT) for nonmuscle-invasive bladder cancer is superior to conventional white-light TURBT for cancer detection. However, when performing PDD-TURBT, cystoscopy findings vary depending on the quality of the endoscopic equipment. In this study, we compared the effects of different types of endoscopic equipment on postoperative
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Phthalocyanine-based probes in alleviating or evading tumour-hypoxia for enhanced photo- and/ sono-mediated therapeutic efficacies Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Lindokuhle Cindy Nene, Heidi Abrahamse
This review discusses the possible methods for improving therapeutic efficacies of phthalocyanine (Pcs) -based therapeutic probes in photo- and sono-dynamic therapies under hypoxic conditions. Herein, the structural design strategies including varying the central metal, position substituents and the effects of adjuvant used in supplementing the therapeutics activities of Pcs or formation of NPs are
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Antimicrobial photodynamic therapy against a dual-species cariogenic biofilm using a ruthenium-loaded resin-based dental material Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Maria Luísa Leite, Patricia Comeau, Sana Aghakeshmiri, Dirk Lange, Lidiany Karla Azevedo Rodrigues, Neil Branda, Adriana Pigozzo Manso
and are associated with caries recurrence. Therefore, this study evaluated the combination of a Ru(II)-loaded resin-based dental material (RDM) and antimicrobial photodynamic therapy (aPDT) against a dual-species biofilm of and . An aPDT protocol was established evaluating Ru(II)'s photocatalytic activity and antimicrobial potential under blue LED irradiation (440–460 nm, 22.55 mW/cm) at different
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Surgery combined with photodynamic therapy for early-stage endometrial carcinoma, a report of two cases Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Mengjiao Zhou, Ting Zhang, Zheng Huang, Chunyan Zhang, Shuyu Yuan, Mengzhuo Zhang, Kaili Dai, Yimeng Wang, Yuehui Su, Mengzhen Zhang
Endometrial carcinoma (EC) is one of the most prevalent gynecological malignancies and the onset age of EC tends to be younger. This case report explored the feasibility of surgery combined with photodynamic therapy (PDT) in two young patients with early-stage EC. A 31 years old patient and a 24 years old patient were treated with surgery and PDT, respectively. The intraoperative PDT was performed
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The effects of antimicrobial photocatalytic nanoparticles on the flexural strength of orthodontic acrylic resins: A systematic review and meta-analysis Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Rashin Bahrami, Nariman Nikparto, Fateme Gharibpour, Maryam Pourhajibagher, Abbas Bahador
Orthodontic acrylic resins containing antimicrobial photocatalytic nanoparticles aims to reduce oral lesions including denture stomatitis and white spot lesions but they should not imperil its mechanical properties. This systematic review was done to evaluate the effect of various photocatalytic nanoparticles on the flexural strength (FS) of acrylic resins. We systematically searched the PubMed/Medline
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Successful treatment by a chlorin e6 derivative mediated photodynamic therapy combined holmium laser for cervical and vaginal giant condyloma acuminata and low-grade intraepithelial neoplasia:a case report Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-22 Yun Wu, Xiaofei Sun, Yu Yan, Zhongxia Zhou, Qihang Chang, Diyan Chen, Jia Yan, Haiyan Zhang, Xiuli Wang
Photodynamic therapy (PDT) is proved effective for treating low-grade squamous intraepithelial lesions (LSIL) and condylomata acuminata (CA). 5-Aminolevulinicacid (5-ALA) is the most common applied photosensitizer, but high rate of unbearable pain and relative long incubation time were reported. Here, we report a 27-year-old woman suffering from cervical and vaginal giant CA with LSIL involving the
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A Novel Investigational Preclinical Model to Assess Fluence Rate for Dental Oral Craniofacial Tissues Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-18 Dennis Sourvanos, Timothy C. Zhu, Andreea Dimofte, Theresa M. Busch, Bradley Lander, Justin C. Burrell, Rodrigo Neiva, Joseph P. Fiorellini
Photodynamic Therapy (PDT) and Photobiomodulation (PBM) are recognized for their potential in treating head and neck conditions. The heterogeneity of human tissue optical properties presents a challenge for effective dosimetry. The porcine mandible cadaver serves as an excellent model and has several similarities to human tissues of the dental oral craniofacial complex. This study aims to validate
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Successful treatment of refractory oral condyloma acuminatum through laser-photodynamic therapy combination Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-17 Yimin He, Wending Gao, Feng Cai, Yingying Zhu, Rongjie Zuo, Huan Liu, Ying Gao
Condyloma acuminatum (CA) is a sexually transmitted disease primarily caused by human papilloma virus (HPV) infection, predominantly affecting the genital and anal regions. However, the occurrence of oral condyloma acuminatum (OCA) is relatively infrequent, although its incidence has been gradually rising in recent years. OCA presents unique challenges in terms of treatment efficacy and recurrence
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Comparative study of topical 5-aminolevulinic acid photodynamic therapy and surgery for recurrent cervical high-grade squamous intraepithelial lesions following surgery Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-17 Bingjie Wang, Shuyu Yuan, Yuehui Su, Chunyan Zhang, Mengjiao Zhou, Mengzhuo Zhang, Kaili Dai, Yimeng Wang, Lili Cao, Ting Zhang, Mengzhen Zhang
The study aimed to compare the clinical efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and surgery in treating recurrent cervical high-grade squamous intraepithelial lesions (HSIL) after surgery due to precancerous lesions. A total of 41 patients with recurrent cervical HSIL after surgery for precancerous lesions were studied retrospectively. Patients underwent ALA-PDT
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Efficacy and influencing factors of CO2 laser, topical photodynamic therapy versus therapy combined with CO2 laser pretreatment for vaginal low-grade squamous intraepithelial lesions with high-risk HPV infection Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-16 Yuling Li, Yingting Wei, Jinhua Huang, Liying Gu, Zubei Hong, Lihua Qiu
Vaginal intraepithelial neoplasia (VaIN) is a group of diseases of squamous epithelial dysplasia and carcinoma occurring in the vagina, which is associated with high-risk human papillomavirus (HR-HPV) infection. To evaluate the efficacy and safety of Carbon dioxide (CO) laser, 5-aminolevulinic acid photodynamic therapy (PDT) and PDT combined with CO laser pretreatment for VaIN1 with HR-HPV infection
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Evaluation of Corneal Densitometry Values with Pentacam in Cases of Ocular Hypertension and Pseudoexfoliative Glaucoma Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-16 Cigdem Coskun, Gökhan Çelik, Cenk Zeki Fikret, Sebile Çomçalı, Ozlem Evren Kemer
Examination of corneal densitometry measurements using the Pentacam Scheimpflug imaging system in cases of pseudoexfoliative glaucoma (PEXG) and ocular hypertension (OHT). The study included 50 eyes of 29 PEXG patients, 25 eyes of 16 OHT patients, and 76 eyes of 38 healthy control subjects followed in the glaucoma clinic. Corneal densitometry values of all cases were measured using the Scheimpflug
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Application of Microneedling in Photodynamic Therapy: a Systematic Review Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-16 Run Tian, Xunyi Wang, Yong Li, Li Zhang, Xiang Wen
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Photobiomodulation's Potential as a Non-Invasive Therapy for Alzheimer's disease and Minimal Cognitive Impairment: A 12-Week Investigation Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-16 Mohammadreza Razzaghi, Fatemeh Sheibani, Negin Kimia, Zahra Razzaghi, Zeynab Chenari, Farzad Ashrafi, Maryam Barati, Soroor Advani
Alzheimer's Disease (AD), undergoing a faster increase in occurrence than any other type of dementia, lacks a curative remedy despite advanced discoveries. To explore the realm of non-pharmacologic therapies, our study evaluates the 12-week impact of non-invasive Photobiomodulation (PBM) on cognitive and psychological aspects in individuals with AD and minimal cognitive impairment (MCI). The urgency
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Combination of biopsy forceps excision and ALA-PDT for the treatment of cervical condylomata acuminata Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-15 Zhongyu Qu, Guoying Cui, Zhifeng Wang, Ming Liu, Xueyan Lin
Human papilloma virus (HPV) infection and cervical condyloma acuminatum (CA) often co-exist. Although there are many methods to treat cervical CA, high recurrence rate and cervical scars are still troublesome. Biopsy forceps excision combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a feasible approach for cervical CA, but its efficacy and limitation need to be evaluated. This retrospective
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Integrating antimicrobial photodynamic therapy into the adjuvant phototherapeutic approach for orofacial manifestations of toxic epidermal necrolysis and Stevens-Johnson syndrome Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-14 Regina Maria Raffaele, Marcia Christina Camargo Hernandes Ramires, Mario Eduardo Baldo, Luiz Felipe Palma, Luana Campos
Characterized by an immune reaction to medications, toxic epidermal necrolysis (TEN) and Steven-Johnson Syndrome (SJS) are potentially fatal mucocutaneous reactions, and their management remains challenging. Considering the promising studies regarding the use of laser in managing orofacial lesions, this study aimed to report two cases in which children presenting with TEN and SJS were treated using
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Posterior segment parameters after uveitic cataract surgery: A prospective study with 1-year results Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-11 Nur Doganay Kumcu, Melike Balikoglu-Yilmaz, Semiha Ozgul, Seher Saritepe Imre
To evaluate the changes in posterior segment after uncomplicated cataract surgery in uveitic patients. Retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), central macular thickness (CMT), and choroidal thickness (CT) of 38 eyes of 28 patients were measured pre- and postoperatively on day 1, week 1, and month 1, 3, 6, 9, and 12. The RNFLT increased after surgery. Although
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Comparative study of the effect of different exposure parameters of 635nm diode laser and toluidine blue O in eliminating Aggregatibacter actinomycetemcomitans biofilm from titanium implant surfaces Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-10 Mahnaz Arshad, Faraz Joshan, Nasim Chiniforush, Shima Afrasiabi
The aim of this study was to investigate the effects of antimicrobial photodynamic therapy (PDT) using 635 nm diode laser irradiation with an energy density of 6 to 30 J/cm and toluidine blue O (TBO) as a photosensitizer on the viability of attached to the surface of titanium implants. Titanium implants contaminated with were treated with TBO alone or in combination with different exposure parameters
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OCTA on the density of optic nerve microvessels in myopic population with ocular hypertension Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-10 Yeqiang Shi, Xuan Chen, Qingfen Tian, Chao Bi
To measure functional, structural, and blood flow parameters of the optic disk in myopic patients with ocular hypertension (OHT) and myopic patients using optical coherence tomography angiography (OCTA), this study aims to investigate the variability of each parameter between the two groups, and to analyze the correlation between the RNFL thickness and blood flow parameters, as well as the diagnostic
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Three-Dimensional Printing of the Human Lung Pleural Cavity Model for PDT Malignant Mesothelioma. Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-10 Dennis Sourvanos, Hongjing Sun, Timothy C. Zhu, Andreea Dimofte, Brook Byrd, Theresa M. Busch, Keith A. Cengel, Rodrigo Neiva, Joseph P. Fiorellini
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Optical coherence tomography angiography assessment of retinochoroidal microcirculation differences in preeclampsia Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-10 Çisil Erkan Pota, Mehmet Erkan Doğan, Gül Alkan Bülbül, Cem Yaşar Sanhal, Ali Pota
: To investigate microvascular changes in pregnant women with preeclampsia using optical coherence tomography angiography (OCTA) and compare the results with healthy pregnant and non-pregnant subjects. Superficial capillary plexus (SCP), deep capillary plexus (DCP) choriocapillaris (CC) vessel density (VD) and foveal avascular zone area (FAZ), retina, retinal nerve fiber layer (RNFL), the ganglion
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PHOTODYNAMIC ACTION OF CATIONIC AND ANIONIC BSA-CURCUMIN NANOPARTICLES ON AMASTIGOTES OF Leishmania braziliensis and Leishmania major and Leishmania amazonensis Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-10 Luciana Maria Cortez Marcolino, Jessica AR Ambrosio, Juliana Guerra Pinto, Isabelle Ferreira, Andreza R Simioni, Juliana Ferreira-Strixino
Cutaneous leishmaniasis is a neglected disease prevalent in tropical countries, and conventional treatment can cause several serious side effects. Photodynamic therapy represents an alternative treatment, as it is non-invasive, has no side effects, is easily accessible, and uses low-cost substances, such as curcumin. This study evaluated the PDT response with cationic and anionic BSA nanoparticles
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Effect of topical 5-aminolevulinic acid-mediated photodynamic therapy combined with CO2 laser pretreatment for vaginal condyloma acuminate Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-09 Shan Jiang, Xia Hu, Xiaoyan Peng, Tiechi Lei
Condyloma acuminatum (CA) of the vagina is a sexually transmitted disease due to infection by human papilloma virus (HPV). The treatment efficacy of the conventional methods for vaginal CA is often unsatisfactory with a high recurrence rate. Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) combined with CO laser pretreatment is a feasible approach for vaginal CA, but the effectiveness
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Hyperspectral imaging for non-invasive blood oxygen saturation assessment Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-08 Jiangbo Wu
Hyperspectral Imaging (HSI) seamlessly integrates imaging and spectroscopy, capturing both spatial and spectral data concurrently. With widespread applications in medical diagnostics, HSI serves as a noninvasive tool for gaining insights into tissue characteristics. The distinctive spectral profiles of biological tissues set HSI apart from traditional microscopy in enabling in vivo tissue analysis
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Effect of antibacterial photodynamic therapy with chitosan nanoparticles on Aggregatibacter actinomycetemcomitans Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-08 Amir Mohammad Kamalou, Ferena Sayar, Babak Iranpour
This study aimed to assess the effect of antibacterial photodynamic therapy (aPDT) with chitosan nanoparticles on in the culture medium. In this in vitro, experimental study, chitosan nanoparticles (CHNPs) containing indocyanine green (ICG) were first synthesized and characterized. was cultured on trypticase soy agar. The culture media containing were randomly subjected to the following six decontamination
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Influence of blue and violet LED and infrared laser on the temperature of bleaching protocols in different concentrations of hydrogen peroxide Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-07 Elma Vieira Takeuchi, Joatan Lucas de Sousa Gomes Costa, Carmem Lúcia de Arroxelas Silva, Antonia Patricia Oliveira Barros, Barbara Leite Machado, Heitor Hussni Casarin, João Felipe Besegato, Milton Carlos Kuga, Cecy Martins Silva
The photo-acceleration of bleaching gels by lights has been extensively researched. However, the induced temperature increase during this process needs to be further evaluated to prevent damage to the dental pulp. Therefore, the objective of this study was to evaluate the surface and intrapulpal temperature kinetics of different concentrations of hydrogen peroxide (HP) gels photo-accelerated by blue
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ALA-PDT Promotes IL-1β Secretion from Human SZ95 Sebocytes via Activation of the NLRP3 Inflammasome Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-07 Jian Zhang, Yufeng Chang, Suqing Liu, Jiang Tuo, Zhongyi Xu, Jiayi Ying, Yijian Zhu, Zhengzhou Shi, Christos C. Zouboulis, Min Jiang, Qianqian Wang, Leihong Xiang
5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for pilosebaceous inflammatory diseases, such as acne vulgaris. In this study, we explored ALA-PDT's mechanisms against acne . We treated human SZ95 sebocytes with ALA (0.2 mM) and subjected them to varied PDT doses (0, 5, 10, 20 J/cm²) over 12 hours. We assessed cell viability post-treatment using the Annexin V FITC/PI
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Distinguishing brain tumors by Label-free confocal micro-Raman spectroscopy Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-07 Jie Liu, Pan Wang, Hua Zhang, Nan Wu
: Brain tumors have serious adverse effects on public health and social economy. Accurate detection of brain tumor types is critical for effective and proactive treatment, and thus improve the survival of patients. : Four types of brain tumor tissue sections were detected by Raman spectroscopy. Principal component analysis (PCA) has been used to reduce the dimensionality of the Raman spectra data.
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IPL-PDT as an effective treatment for mild-to-moderate acne vulgaris: A prospective, single-center, self-controlled study Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-07 Qihang Chang, Xiaojing Liu, Peiru Wang, Yutong Yang, Linglin Zhang, Bo Wang, Xiuli Wang
High recurrence rate of mild-to-moderate acne vulgaris following traditional therapy poses a significant challenge. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) with intense pulsed light (IPL) has emerged as a promising intervention. This study aimed to evaluate the efficacy and safety of IPL-PDT for the treatment of mild-to-moderate acne vulgaris. In this prospective, self-controlled study
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Corrigendum to “Fluorinated triphenylamine silicon phthalocyanine nanoparticles with two-color imaging guided in vitro photodynamic therapy through lysosomal dysfunction” [Photodiagnosis and Photodynamic Therapy 43 (2023) 103734] Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-06 Fangmei Zheng, Yan Huang, Yating Shen, Guizhi Chen, Yiru Peng, Xuemei Zhuang
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Potential therapeutic efficacy of photodynamic therapy on female hormonal-dependent cancers in a hormonal simulated microenvironment Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-03 Ellie Shihng-meir Chu, Ricky Wing-kei Wu, Zheng Huang
Photodynamic Therapy (PDT) is a clinically approved cancer treatment. Sex hormones, the key drivers for the development of female hormonal dependent cancers, might affect cancer treatment. There are seldom studies to evaluate the effect of sex hormones mimicked the menstrual cycle on the PDT mediated by prodrug 5-aminolevulinic acid (ALA) and its ester derivatives to the hormonal dependent cancers
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A prospective, split-face, randomized controlled trial of intense pulsed light-photodynamic therapy for seborrhea Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-03 Dixin Wang, Yu Yan, Peiru Wang, Haiyan Zhang, Yajing Cao, Bo Wang, Linglin Zhang, Xiuli Wang
: Seborrhea poses a common cosmetic concern in adolescents and young adults, often accompanied by enlarged pores, and contributing to various skin conditions, including acne vulgaris and seborrheic dermatitis. At present, there is a lack of effective treatment for this problem, and the potential of photodynamic therapy (PDT) in reducing sebum remains inconclusive. : This exploratory, prospective, single-center
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Efficacy of Methylene Blue-Mediated Antimicrobial Photodynamic Therapy on Clinical and Radiographic Outcomes Among Patients with Periodontal Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-03 Mohammed N. Alasqah
This study aimed to assess the influence of methylene blue (MB)-mediated adjunctive antimicrobial photodynamic therapy (aPDT) when compared to conventional mechanical debridement (MD) alone on periodontal clinical and radiographic outcomes among periodontitis patients. Randomized clinical trials (RCTs) were incorporated by conducting an electronic search in Web of Science, Scopus, and PubMed for articles
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Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: a case report Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-30 Lucas Peixoto de Araújo, Analu Rodriguez Marchesin, Lucas Pinto Carpena, Leandro Bueno Gobbo, Nadia de Souza Ferreira, José Flávio Affonso de Almeida, Caio Cezar Randi Ferraz
Introduction: Persistent apical periodontitis after root canal treatment may require surgical retreatment when non-surgical options are ineffective or impractical due to anatomical challenges or iatrogenic errors. Endodontic microsurgery (EMS) is a precise technique that aims to overcome extraradicular biofilm and root morphology issues. Photodynamic therapy (PDT) is an emerging supplementary disinfection
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Photodynamic therapy of vaginal intraepithelial neoplasia—How to do it? Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-02-01 Xiaoyun Wang, Haixia Qiu, Huiqi Zhan, Zheng Huang
Vaginal intraepithelial neoplasia (VaIN or VAIN), a rare precancerous disease, is difficult to treat. Photodynamic therapy (PDT) is a relatively new modality for the treatment of various precancerous mucosal lesions of the lower genital organs, including VaIN. Due to the special structure and location of the vagina, it is difficult to apply photosensitizer and light irradiation to VaIN lesions. This
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Combination of vitamin D and photodynamic therapy enhances immune responses in murine models of squamous cell skin cancer Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-27 Sanjay Anand, Alan Shen, Cheng-En Cheng, Jacky Chen, Jennifer Powers, Pat Rayman, Marcela Diaz, Tayyaba Hasan, Edward V Maytin
Improved treatment outcomes for non-melanoma skin cancers can be achieved if Vitamin D (Vit D) is used as a neoadjuvant prior to photodynamic therapy (PDT). However, the mechanisms for this effect are unclear. Vit D elevates protoporphyrin (PpIX) levels within tumor cells, but also exerts immune-modulatory effects. Here, two murine models, UVB-induced actinic keratoses (AK) and human squamous cell
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In vitro evaluation of the efficacy of photodynamic therapy using 5-ALA on homologous feline mammary tumors in 2D and 3D culture conditions and a mouse subcutaneous model with 3D cultured cells Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-26 Siyao Lin, Urara Ota, Hideo Imazato, Kiwamu Takahashi, Masahiro Ishizuka, Tomohiro Osaki
Background Numerous studies have shown that photodynamic therapy (PDT) has a therapeutic effect on mammary tumor cells, with 5-aminolevulinic acid (5-ALA-HCL) being a commonly used photosensitizer for PDT. Feline mammary tumors (FMTs) are relatively common. However, the cytotoxic and antitumor effects of 5-ALA-PDT on FMTs have not been clarified. To this end, we evaluated the therapeutic effect of
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In vitro effects of Er: YAG laser-activated photodynamic therapy on Enterococcus faecalis in root canal treatment Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-26 Guofeng Yang, Weiting Chen
Objective Photodynamic therapy (PDT) plays an important role for root canal disinfection. Nevertheless, the effect of photosensitizers penetrating dentin tubules is limited, which ultimately impedes the disinfection effect of PDT. The study implements an Er: YAG laser to activate methylene blue, the photosensitizer, to determine the bactericidal impact of PDT on Enterococcus faecalis in vitro root
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Effects of repeated etching cycles using 15% hydrochloric acid on enamel loss and relative attenuation coefficient in resin infiltration Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-26 Dayang Fadzlina Abang Ibrahim, Noren Nor Hasmun, Yih Miin Liew, Annapurny Venkiteswaran
Background Resin infiltration is used to mask enamel opacities and the recommended etching cycles are three. However, anecdotal evidence suggests that favorable esthetics outcomes can be obtained by increasing the etching cycles. Aim To determine the incremental and total enamel loss when enamel surfaces are exposed to multiple etching cycles and to assess the relative attenuation coefficient after
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Antimicrobial photodynamic therapy for managing the peri-implant mucositis and peri-implantitis: A systematic review of randomized clinical trials Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-24 Rashin Bahrami, Nariman Nikparto, Fateme Gharibpour, Maryam Pourhajibagher, Abbas Bahador
Background The presence of peri-implant inflammation including peri-implant mucositis and peri-implantitis, is a crucial factor that impacts the long-term stability and success of dental implants. This review aimed to evaluate the safety and effectiveness of antimicrobial photodynamic therapy (aPDT) as an adjuvant therapy option for managing peri-implant mucositis and peri-implantitis. Methods We systematically
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Spectrophotometric Analysis of The Effectiveness of Different Dentin Tubule Occlusion Techniques in Preventing Discoloration Caused by Photosensitizers Used in Photodynamic Therapy Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-23 Anıl Berker CENGİZ, Zeliha UĞUR AYDIN
Aim The efficacy of Copal Varnish (CV), dentin bonding agent (DBA), Nd:YAG laser and Er:YAG laser, which occludes dentin tubules by different mechanisms, was investigated in order to prevent unwanted coloration caused by methylene blue (MB) and phthalocyanine used in photodynamic therapy (PDT). Materials and Methods : 165 upper incisors included in the study. Root canals were prepared up to 30/0.6
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The efficacy of 5-aminolevulinic acid photodynamic therapy for pediatric vulvar lichen sclerosus Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-24 Shan Zhang, Yukun Wang, Juncheng Wang, Jie Liu
Background Prepubertal girls are one of the vulnerable populations of vulvar lichen sclerosus (VLS), which results in a decreased quality of life and increases risk of vulvar cancer. But the therapeutic effects of traditional topical remedies are unsatisfactory in some pediatric patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for refractory VLS patients, but
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Fluorescence Spectroscopic Profiling of Urine Samples for Predicting Kidney Transplant Rejection Photodiagn. Photodyn. Ther. (IF 3.3) Pub Date : 2024-01-18 Zhe Yang, Minrui Zhang, Xianduo Li, Zhipeng Xu, Yi Chen, Xiaoyu Xu, Dongdong Chen, Lingquan Meng, Xiaoqing Si, Jianning Wang
Rejection is the primary factor affecting the functionality of a kidney post-transplant, where its prompt prediction of risk significantly influences therapeutic strategies and clinical outcomes. Current graft health assessment methods, including serum creatinine measurements and transplant kidney puncture biopsies, possess considerable limitations. In contrast, urine serves as a direct indicator of