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Date (Phoenix dactylifera L. Mill) fruit enhances sexual performance via modulation of oxido-inflammatory mediators and purinergic signaling in hypertensive male rats Biomarkers (IF 2.6) Pub Date : 2024-03-14 Adeniyi A. Adebayo, Ayokunle O. Ademosun, Ganiyu Oboh
Introduction: The present study aimed at investigating the effect of dietary supplementation of Phoenix dactylifera, an important component of aphrodisiac supplements, on sexual performance, oxido-...
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Interpreting quantitative RNA expression prognostic and predictive results generated from synchronous rather than solitary breast cancers Biomarkers (IF 2.6) Pub Date : 2024-03-04 Steven Sorscher, Priya Gor
Published in Biomarkers (Just accepted, 2024)
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Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis Biomarkers (IF 2.6) Pub Date : 2024-03-01 Raphael Enrique Tiongco, Neil David Cayanan, Miljun Catacata, Michael John Dominguez
Background and Objective: Several genetic variations are associated with acute myeloid leukemia (AML) susceptibility, including the GSTP1 Ile105Val polymorphism. Even with the existing meta-analysi...
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Prognostic and clinicopathological value of osteopontin expression in non-small cell lung cancer: a meta-analysis and systematic review Biomarkers (IF 2.6) Pub Date : 2024-02-29 Yu Song, Haibo Li, Qing Jiang, Lianghong Wu
Although Osteopontin (OPN) has been reported to be associated with many different human cancers, the data on non-small cell lung cancer (NSCLC) are not definitive. This study aimed to explore the p...
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Circulating tRNA-derived fragments are decreased in patients with rheumatoid arthritis and increased in patients with psoriatic arthritis Biomarkers (IF 2.6) Pub Date : 2024-02-27 Marina Dunaeva, Jan Blom, Rogier Thurlings, Margot van Weijsten, Fons A.J. van de Loo, Ger J. M. Pruijn
tRNA-derived fragments (tRFs) play an important role in immune responses. To clarify the role of tRFs in autoimmunity we studied circulating tRF-levels in patients with rheumatoid arthritis (RA) an...
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Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined? Biomarkers (IF 2.6) Pub Date : 2024-02-27 Alan H.B. Wu, Chia-Ching Wang
Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation stu...
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High tissue FRMD6 expression predicts better outcome among colorectal cancer patients Biomarkers (IF 2.6) Pub Date : 2024-02-22 Arthur vonKoskull, Jaana Hagström, Caj Haglund, Tuomas Kaprio, Camilla Böckelman
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths. The hippo pathway works as a regulator of organ growth and is often a target for mutations in cancer. Ferm domain c...
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Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker Biomarkers (IF 2.6) Pub Date : 2024-02-20 Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H. Ibrahim
Sepsis, a leading cause of mortality globally, has a complex and multifaceted pathophysiology which still requires elucidation. Therefore, this study aimed to analyze and quantify the number of exo...
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Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma Biomarkers (IF 2.6) Pub Date : 2024-02-15 Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki, Kenei Furukawa, Masanori Nakano, Yuichi Torisu, Toru Ikegami, Kiyotsugu Yoshida, Masayuki Saruta
The conventional markers for hepatocellular carcinoma (HCC), α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), have several limitations; both have low sensitivity in patients with early-stag...
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Investigating the Diagnostic Potential of IL-1β, IL-10, and IL-36γ in Gingival Crevicular Fluid in Patients with Different Periodontal Conditions Biomarkers (IF 2.6) Pub Date : 2024-02-12 Mihtikar GÜRSEL, Tuba BAYAT, Niyazi DÜ NDAR, Ayşegül YABACI TAK, Burcu KARADUMAN
Published in Biomarkers (Just accepted, 2024)
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The role of ASXL1 mutations and ASXL1 CircRNAs in cancer Biomarkers (IF 2.6) Pub Date : 2024-02-12 Narges Jafarbeik-Iravani, Sara Kolahdozan, Rezvan Esmaeili
Mutations in the Additional Sex Combs Like 1 (ASXL1) gene were first reported in myelodysplastic syndromes. Recent studies have clarified the relationship between ASXL1 mutations and the developmen...
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Phœnix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats Biomarkers (IF 2.6) Pub Date : 2024-02-05 Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine
Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L. seed oil (DSO) on a murine model of IPF induc...
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Subchronic exposure to fenpyroximate causes multiorgan toxicity in Wistar rats by disrupting lipid profile, inducing oxidative stress and DNA damage Biomarkers (IF 2.6) Pub Date : 2024-02-05 Imen Ayed-Boussema, Karima Rjiba, Asma M’nassri, Hiba Hamdi, Salwa Abid
Fenpyroximate (FEN) is an acaricide that inhibits the complex I of the mitochondrial respiratory chain in mites. Data concerning mammalian toxicity of this acaricide are limited; thus the aim of th...
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Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility Biomarkers (IF 2.6) Pub Date : 2024-02-05 Gungor Gul, Mehmet Akif Aydin, Sermin Algul, Remzi Kiziltan, Ozgur Kemik
The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer...
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Assessing angiogenesis factors as prognostic biomarkers in breast cancer patients and their association with clinicopathological factors Biomarkers (IF 2.6) Pub Date : 2024-02-05 Tannaz Abbasi-Dokht, Farhad Malek, Nahid Nafissi, Maryam Mohammadlou, Maryam Sheikh, Sedigheh Akbari, Mohammad Hossein Zargaran, Rasoul Baharlou
Angiogenesis is fundamental for tumor growth and metastasis across many solid malignancies. Considerable interest has focused on the molecular regulation of tumor angiogenesis as a means to predict...
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Deciphering the potential of proteomic-based biomarkers in women’s reproductive diseases: empowering precision medicine in gynecology Biomarkers (IF 2.6) Pub Date : 2024-02-01 Ishwerpreet Kaur Jawanda, Thomson Soni, Seema Kumari, Vijay Prabha
Gynecological disorders represent a complex set of malignancies that result from a diverse array of molecular changes affecting the lives of over a million women worldwide. Ovarian, Endometrial, an...
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A cross talk on the role of contemporary biomarkers in depression Biomarkers (IF 2.6) Pub Date : 2024-01-31 Aditi Vyas, Gaurav Doshi
Introduction: Biomarkers can be used to identify determinants of response to various treatments of mental disorders. Evidence to date demonstrates that markers of inflammatory, neurotransmitter, ne...
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Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study Biomarkers (IF 2.6) Pub Date : 2024-01-22 Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander
The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.Cardiovascular biomar...
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Comet assay as a suitable biomarker for in vivo oral carcinogenesis: a systematic review Biomarkers (IF 2.6) Pub Date : 2024-01-22 Thiago Guedes Pinto, Daniel Vitor de Souza, Glenda Nicioli da Silva, Daisy Maria Favero Salvadori, Manoela Domingues Martins, Daniel Araki Ribeiro
In order to detect genetic damage, different methods have been developed, such as micronuclei and comet assay. The comet assay presents some advantages when compared to the other aforementioned met...
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A future blood test for acute traumatic spinal cord injury Biomarkers (IF 2.6) Pub Date : 2024-01-22 Tej D. Azad, Kathleen R. Ran, Jiaqi Liu, Vikas N. Vattipally, Harmon Khela, Enzo Leite, Joshua D. Materi, A. Daniel Davidar, Chetan Bettegowda, Nicholas Theodore
Acute spinal cord injury (SCI) requires prompt diagnosis and intervention to minimize the risk of permanent neurologic deficit. Presently, SCI diagnosis and interventional planning rely on magnetic...
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The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy Biomarkers (IF 2.6) Pub Date : 2024-01-22 Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao
There are many factors that affect the survival of patients with gastric cancer, such as TNM stage, the patient’s nutritional status, inflammation, and so on. In this study, the prognostic signific...
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Detection and modification of biomarkers of inflammation determining successful rhythm control in patients with atrial fibrillation Biomarkers (IF 2.6) Pub Date : 2024-01-22 Tobias Schreiber, Jana Grune, Ulf Landmesser, Philipp Attanasio
Multiple pathophysiological mechanisms are involved in the pathogenesis of atrial fibrillation (AF). Growing evidence suggests that both local and systemic inflammation plays a key role even in ear...
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Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer Biomarkers (IF 2.6) Pub Date : 2023-12-11 Ghassan M. Saed, Asad Nawaz, Ayesha A. Alvero, Amy K. Harper, Robert T. Morris
Background: Ovarian cancer cells are known to express myeloperoxidase (MPO), an oxidant-producing enzyme with a 150 kDa homodimer, consisting of two identical monomers connected by a disulfide bond...
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Polymorphisms in ERCC1, ERCC4 and ERCC5 genes as biomarkers of susceptibility for pesticide-induced DNA damage in North-West Indian agricultural workers Biomarkers (IF 2.6) Pub Date : 2023-12-11 Karashdeep Kaur, Rupinder Kaur
Occupational pesticides exposure has raised health concerns due to genotoxicity and accumulation of DNA damage. Polymorphisms in genes encoding enzymes involved in nucleotide excision repair (NER) ...
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MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers Biomarkers (IF 2.6) Pub Date : 2023-12-11 Joana M. O. Santos, Valéria Tavares, Rui M. Gil da Costa, Rui Medeiros
High-risk human papillomavirus (HPV) is the aetiological agent of cervical cancer, which remains the fourth leading cause of cancer death in women worldwide. K14-HPV16 transgenic mice are a model f...
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Arginase is upregulated in healthy women infected by oncogenic HPV types Biomarkers (IF 2.6) Pub Date : 2023-12-11 Moufida Souid, Jaweher Bday, Sameh Souissi, Randa Ghedira, Sallouha Gabbouj, Salwa Shini-Hadhri, Dhekra Toumi, Haifa Bergaoui, Ines Zouari, Raja Faleh, Abdelfatteh Zakhama, Elham Hassen
The implication of arginase enzyme in Human Papillomavirus (HPV) infections has not been clearly elucidated. The present study investigates whether HPV infection is correlated with changes in plasm...
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Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants Biomarkers (IF 2.6) Pub Date : 2023-12-11 Deepak Bhandari, Yuyang Zhu, Can Zhang, Wanzhe Zhu, Apostolos Alexandridis, Arash Etemadi, Neal D. Freedman, Cindy Chang, Christian C. Abnet, Sanford M. Dawsey, Maki Inoue-Choi, Hossein Poustchi, Akram Pourshams, Paolo Boffetta, Reza Malekzadeh, Benjamin Blount
Background. Benzene is a known human carcinogen. Human exposure to benzene can be assessed by measuring trans, trans-muconic acid (MUCA) in urine. Golestan Province in northeastern Iran has been re...
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Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma Biomarkers (IF 2.6) Pub Date : 2023-12-11 Qiang Li, Yanfei Jia, Bo Tang, Hu Yang, Qiang Yang, Xiaodong Luo, Yawen Pan
Medulloblastoma is the most common malignant brain tumor in children. There are four groups, each with different causal mutations, affected pathways and prognosis. Here, we investigated the role of...
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Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite Biomarkers (IF 2.6) Pub Date : 2023-12-11 Mariam M. Abd El-Azim, Mona K. Mousa, Ragaa M. Abdelmaaboud, Nabil N. Rezq, Sarah S. Mohammed
This study aimed to assess the predictive value of NLR, PLR, and MPV time series for diagnosis and prognosis of hemotoxic snakebite envenomation.This is a prospective study among snakebite patients...
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Association of occupational exposure to pesticides with overweight in farmers in Southern Brazil Biomarkers (IF 2.6) Pub Date : 2023-12-11 Calinca Skonieski, Karina Raquel Fagundes, Larissa da Silva, Hecson Jesser Segat, Anderson Joel Martino Andrade, Rodrigo Cordeiro Bolzan, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira, Dalila Moter Benvegnú
Exposure to pesticides may be related to overweight and associated comorbidities. The aim of this work was to evaluate occupational exposure to pesticides, overweight and associated comorbidities a...
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Predictive biomarkers for colorectal cancer: a state-of-the-art systematic review Biomarkers (IF 2.6) Pub Date : 2023-09-12 Moeez Maqbool, Aden Khan, Areej Shahzad, Zouina Sarfraz, Azza Sarfraz, Hinna Aftab, Ali Jaan
Colorectal cancer (CRC) poses a substantial health burden, with early detection paramount for improved prognosis. This study aims to evaluate potential CRC biomarkers and detection techniques.This ...
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Identification of the ATPase alpha subunit of Trypanosoma cruzi as a potential biomarker for the diagnosis of Chagas disease Biomarkers (IF 2.6) Pub Date : 2023-09-10 M. Morales-Velásquez, J. P. Barón-Vera, M. I. Pulgarín-Osorio, M. M. Sánchez-Jiménez, J. D. Ospina-Villa
Chagas disease (CD) is considered by the World Health Organisation (WHO) a neglected disease endemic to the Americas, but it has spread throughout the world due to migrations. The disease is almost...
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Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat Biomarkers (IF 2.6) Pub Date : 2023-08-27 Latifa Hajri, Haifa Othman, Soumaya Ghodbane, Mohsen Sakly, Hafedh Abdelmelek, Khemais Ben Rhouma, Mohamed Ammari
Oxidative stress has been implicated in the pathogenesis of diverse disease states. The present study was designed to examine the effects of magnesium sulphate (MgSO4) against hydrogen peroxide (H2...
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Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat Biomarkers (IF 2.6) Pub Date : 2023-08-23 Feiza Belhadjali, Slim Ghrir, Féryel Ksia, Ferid Limam, Ezzedine Aouani, Meherzia Mokni
The aim of the present study was to investigate the effects of Grape seed extract (GSE) and exercise training on Doxorubicin (Doxo)-induced cardio, hepato and myo toxicities in healthy rats.Thirty ...
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Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance Biomarkers (IF 2.6) Pub Date : 2023-08-13 Munevver Gizem Hekım, Sibel Ozcan, Mesut Yur, Nilgun Yıldırım, Mete Ozcan
Breast cancer is a leading cause of cancer death in women worldwide, and early detection is crucial for effective treatment. Mitochondrial dysfunction has been linked to cancer development and prog...
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Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects Biomarkers (IF 2.6) Pub Date : 2023-07-13 Zheng Lian, Zheng Ma, Zhi-Li Zhang, Pei-Lin Liu, Guo-Yong Zhang, Cai-Xia Guo
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with heart failure and stroke, leading sometimes to death. But the pathogenesis of AF remains unclear. Numerous studies ha...
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Conjunctival microbiome changes in soft contact lens users and contact lens discomfort patients Biomarkers (IF 2.6) Pub Date : 2023-07-11 Kang Xiao, Hang Song, Zhengyu Chen, Qin Long
Contact lens discomfort (CLD) acts as a challenging problem, and the associated conjunctival microbiome changes were unclear.Conjunctival sac swab samples were collected from 12 eyes of nonwearers ...
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Meta-analysis of the prognostic value of soluble programmed death ligand-1 (sPD-L1) in cancers Biomarkers (IF 2.6) Pub Date : 2023-07-02 Jinfan Sun, Shuenqin Hu, Xiuying Li
The soluble programmed death ligand-1 (sPD-L1) and its prognostic role in cancers have been investigated in numerous studies. However, due to the inconsistency on some findings, this meta-analysis ...
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Exosomal miRNAs and breast cancer: a complex theranostics interlink with clinical significance Biomarkers (IF 2.6) Pub Date : 2023-06-29 Sayantanee Mukherjee, Rajib Dhar, Swathi Jonnalagadda, Sukhamoy Gorai, Sagnik Nag, Rishav Kar, Nobendu Mukerjee, Dattatreya Mukherjee, Rishabh Vatsa, Devi Arikketh, Anand Krishnan, Rohit Gundamaraju, Saurabh Kumar Jha, Athanasios Alexiou, Marios Papadakis
Breast cancer (BC) remains the most challenging global health crisis of the current decade, impacting a large population of females annually. In the field of cancer research, the discovery of extra...
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Anti-Mullerian hormone and cardiometabolic status: a systematic review Biomarkers (IF 2.6) Pub Date : 2023-06-12 Aida Fallahzadeh, Fahimeh Ramezeni Tehrani, Malihe Rezaee, Fatemeh Mahboobifard, Mina Amiri
To summarise the relationship between Anti-mullerian hormone (AMH) levels and cardiometabolic status in different populations.PubMed, Scopus, and Embase were searched for retrieving observational s...
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Utilizing circulating tumour DNA as a prognostic predictor of gastric cancer: a meta-analysis Biomarkers (IF 2.6) Pub Date : 2023-05-30 Liang Min, Jinghua Chen, Meihong Yu, Ke Yang, Deliang Liu
Abstract Background: Circulating tumour DNA (ctDNA) has demonstrated robust diagnostic accuracy in several digestive cancers. However, the prognostic role of ctCDNA in gastric cancer (GC) is still controversial. This systematic review and meta-analysis aimed to evaluate the prognostic value of ctDNA in GC. Methods: PubMed, Web of Science and Cochrane databases were searched to identify studies reporting
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Serum biomarkers for monitoring response to tuberculosis treatment: an assessment of the effect of different covariates among slow and fast treatment responders Biomarkers (IF 2.6) Pub Date : 2023-05-21 Anna Ritah Namuganga, Bernard Ssentalo Bagaya, Novel N. Chegou, Harriet Mayanja-Kizza
Abstract Introduction The long duration of tuberculosis treatment, as well as the 2-year post-treatment follow-up period often required for predicting relapse, present a hindrance to drug development and treatment monitoring efforts. Therefore, there is need for treatment response biomarkers to inform treatment time shortening, clinical decision-making, and inform clinical trials. Objectives To assess
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CircRNA CDR1as: a novel diagnostic and prognostic biomarker for gastric cancer Biomarkers (IF 2.6) Pub Date : 2023-05-21 Rong Li, Xinyu Tian, Jiajia Jiang, Hui Qian, Han Shen, Wenrong Xu
Circular RNA (circRNA) CDR1as is emerging as a vital tumour regulator. This study aimed to investigate its diagnostic and prognostic value and molecular mechanisms for gastric cancer (GC).CDR1as ex...
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Perspectives on cardiovascular biomarkers: one fits all biomarkers are out, personalization is in. Biomarkers (IF 2.6) Pub Date : 2023-06-01 Martin Möckel
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Potential utility of B-type natriuretic peptides in secondary prevention following percutaneous coronary intervention in remote communities of Western Australia Biomarkers (IF 2.6) Pub Date : 2023-05-11 Peter J. Tually, Geoff Currie, Nat P. Lenzo, Delia V. Hendrie, Jack W. Meadows, Johan H. A. Janssen
Abstract Introduction A third of all acute coronary events that present in the Australian population occur in patients with established coronary heart disease. This study assessed the prognostic value of combined B-type natriuretic peptides (BNP) measurement and quantitative myocardial perfusion scan (MPS) data for cardiac events (CE). Material and methods This retrospective cohort study involved 133
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Development and Validation of a Urinary microRNA Biomarker Panel as a Tool for Early Detection of Prostate Cancer in a Chinese Population Biomarkers (IF 2.6) Pub Date : 2023-04-26 Nan Zhan, Jianfeng Wang, Shigeng Zhang, Huifeng Wu, Zhongyi Li, Maolin Hu
Introduction: Urinary microRNAs (miRNAs) may serve as promising biomarkers for non-invasive early detection of prostate cancer (PCa). We aimed to identify multi-miRNA urinary biomarker panel for early detection of PCa. Methods: Urine samples from 83 PCa patients and 88 healthy control subjects in a Chinese population were collected for miRNA profiling. The absolute expression of 360 unique miRNAs were
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Abstracts for the 17th Annual Biomarkers and Personalized Medicine in Cardiovascular Disease Symposium Biomarkers (IF 2.6) Pub Date : 2023-04-19 Lori Daniels
Published in Biomarkers (Just accepted, 2023)
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ZNF503 combined with GATA3 is a prognostic factor in triple-negative breast cancer Biomarkers (IF 2.6) Pub Date : 2023-04-17 Siyu Liu, Xiaobin Cao, Jing Li, Jingjing Liu
Abstract Purpose Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis. Therefore, there is an urgent need to identify prognostic markers to improve current treatment and therapeutic strategies. The transcriptional factor ZNF503 has been reported to promote aggressive breast cancer development through the down-regulation of GATA3 expression and has been identified as
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Antioxidant-rich Terminalia catappa fruit exerts antihypertensive effect via modulation of angiotensin-1-converting enzyme activity and H2S/NO/cGMP signalling pathway in Wistar rats Biomarkers (IF 2.6) Pub Date : 2023-04-10 Adeniyi A. Adebayo, Ayokunle O. Ademosun, Bukola C. Adedayo, Ganiyu Oboh
Abstract Introduction The present study aimed at investigating the effect of Terminalia catappa fruits on blood pressure, NO/cGMP signalling pathway, angiotensin-1-converting enzyme and arginase activity, and oxidative stress biomarkers in L-NAME-induced hypertensive rats. Materials and methods Forty-two Wistar rats were divided into seven groups. Hypertension was induced via oral administration of
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The role of differentially expressed miR-660 in peripheral blood lymphocytes of patients with pulmonary tuberculosis Biomarkers (IF 2.6) Pub Date : 2023-04-09 Mu Lin, Mubo Liu, Xiaojing Han, Xue Tao, Zhu Tang, Qingqing Ma
Abstract Objective This study aimed to investigate the significance of miRNA expression levels in peripheral blood lymphocytes of patients clinically diagnosed with pulmonary tuberculosis. Method Pulmonary tuberculosis-related datasets in the Gene Expression Omnibus (GEO) database were analyzed, and DE-miRNAs were screened for Gene Ontology (GO) analysis and Kyoto Encyclopaedia of Genes and Genomes
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Usefulness of serum procalcitonin and point-of-care multiplex PCR gastro-intestinal panel in acute diarrhea or colitis in the emergency department Biomarkers (IF 2.6) Pub Date : 2023-03-20 Marta Cancella de Abreu, Clementine Cassard, Ilaria Cherubini, Enfel Houas, Agnès Dechartres, Pierre Hausfater
Abstract Introduction: Acute infectious diarrhea is one of the most common diseases worldwide. Procalcitonin (PCT) is useful for antibiotic stewardship in lower respiratory tract infections but has been poorly studied in infectious diarrhea. Our objective is to describe the PCT concentrations according to diarrhea etiology. Methods: This is a single-center prospective cohort study involving adults
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In-vivo assessment of inflammatory cytokines induced oxidative stress signaling, and troponin I gene dysregulation in cardiac tissue associated with chronic administration of Boldenone and Tramadol, alone or in combination. Biomarkers (IF 2.6) Pub Date : 2023-03-18 Marwa E. A. El-Shamarka, Gihan F. Asaad, Noha A. Mowaad, Magy R. Kozman
Abstract Introduction The risk of cardiotoxicity is associated with the use of anabolic-androgenic steroids and analgesics, several deaths were attributed to such medications. Objectives This study investigates the effects of boldenone (BOLD) and tramadol (TRAM) alone or in combination on the heart. Material and methods Forty adult male rats were divided into four groups. Normal control group, BOLD
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Golgi Signaling Proteins GOLPH3, MYO18A, PITPNC1 and RAB1B: Implications in Prognosis and Survival Outcomes of AML Patients Biomarkers (IF 2.6) Pub Date : 2023-03-15 Yomna Ali, Sara M. Radwan, Alia Saeed, Hala El-Mesallamy
ABSTRACT Introduction The role of different Golgi signaling proteins remains unexplored in the progression and spread of Acute myeloid leukemia (AML), whom all interact together in a way that facilitates proliferation and differentiation of myeloid lineage cells. Material & methods: This study comprised 70 newly diagnosed AML patients and 20 healthy controls to investigate the serum levels of signaling
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Detection of MET gene somatic mutations in hepatocellular carcinoma of Egyptian patients using next-generation sequencing Biomarkers (IF 2.6) Pub Date : 2023-02-24 Ehab Ahmed, Nour El-Dien, Salwa Sabet, Mohamed Khalifa, Manal El Hamshary
Introduction Hepatocellular carcinoma (HCC) is the sixth most common type of cancer worldwide and fourth in Egypt. Liquid biopsy is important to get cell-tumor DNA (ctDNA), for subsequent utilization as a biomarker for cancer diagnosis, prognosis, and treatment. In clinical oncology, ctDNA analysis is utilized in cancer screening. Methods The collected 48 blood samples from HCC patients were classified
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Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes Biomarkers (IF 2.6) Pub Date : 2023-02-12 Melissa Amrein, Stephanie Meier, Ibrahim Schäfer, Sabine Schaedelin, Eline Willemse, Pascal Benkert, Joan Walter, Christian Puelacher, Tobias Zimmermann, Daniela Median, Caroline Egli, David Leppert, Raphael Twerenbold, Michael Zellweger, Jens Kuhle, Christian Mueller
Abstract Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known to be elevated by cardiovascular (CV) risk factors and cerebrovascular small-vessel diseases. Due to their pathophysiological similarities
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Potential Biomarkers in Endometrial Cancer: A Narrative Review Biomarkers (IF 2.6) Pub Date : 2023-02-08 Kareena Moara, Anuja Panta Vikas Sainia, Pawan Kumar Mauryaa
Abstract Context Every year, approximately 0.4 million women suffer from endometrial cancer (EC) worldwide and it has become the most common gynecological malignancy. Almost 66% of EC cases are diagnosed at an early stage and can be cured by performing surgery while those at an advanced stage turns out to be fatal. Biomarkers of endometrial cancer would be very valuable for screening of women who are
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Downregulation of IRAIN long non-coding RNA predicts unfavourable clinical outcome in acute myeloid leukaemia patients Biomarkers (IF 2.6) Pub Date : 2023-01-29 Mohamed A. R. Hussein, Amr E. Ahmed, Yasser ElNahass, Dina El-Dahshan, Mohamed A. M. Ali
Abstract Background Although it has been shown that the long non-coding RNA (lncRNA) insulin-like growth factor type 1 receptor (IGF1R) antisense imprinted non-protein coding RNA (IRAIN) is downregulated in leukaemia cell lines, its usefulness as a prognostic marker in acute myeloid leukaemia (AML) has not yet been thoroughly investigated. Here, we sought to determine whether the expression of IRAIN
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Thymidine kinase activity levels in serum can identify HR+ metastatic breast cancer patients with a low risk of early progression (SWOG S0226) Biomarkers (IF 2.6) Pub Date : 2023-01-29 Mattias Bergqvist, Adrian Nordmark, Amy Williams, Costanza Paoletti, William Barlow, Erin F. Cobain, Rita S. Mehta, Julie R. Gralow, Gabriel N. Hortobagyi, Kathy S. Albain, Lajos Pusztai, Priyanka Sharma, Andrew K. Godwin, Alastair M. Thompson, Daniel F. Hayes, James M. Rae
Abstract Background Some patients with metastatic breast cancer (MBC) stay on endocrine therapy (ET) for years and others progress quickly. Serum thymidine kinase activity (TKa), an indicator of cell-proliferation, is a potential biomarker for monitoring ET and predicting MBC outcome. We have previously reported TKa as being prognostic in MBC in SWOG S0226. Here, new data on progression within 30/60 days
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Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer’s rat model Biomarkers (IF 2.6) Pub Date : 2023-01-29 Mervat Hassan, Hisham Ismail, Olfat Hammam, Abdullrahman Elsayed, Othman Othman, Sohair Aly Hassan
Abstract Background: Phytochemicals have amazing biological effects in relation to age-related illnesses and are increasingly being studied in clinical trials. The goal of this study was to examine the effectiveness of the aqueous extracts of Rosmarinus officinalis L. (Rosemary) and Crocus sativus L. (Saffron) and their combinations as tau and β-amyloid antagonists in an Alzheimer’s rat model. Methods:
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Leaf extract of Anacardium occidentale ameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester (L-NAME) treated rats Biomarkers (IF 2.6) Pub Date : 2023-01-25 Ademola Adetokunbo Oyagbemi, Adedeji Kolawole Adebayo, Olamide Elizabeth Adebiyi, Kabirat Oluwaseun Adigun, Oluwabusayo Racheal Folarin, Oluwaseun Olanrewaju Esan, Temitayo Olabisi Ajibade, Blessing Seun Ogunpolu, Olufunke Olubunmi Falayi, Iyanuoluwa Omolola Ogunmiluyi, Temidayo Olutayo Omobowale, Olufunke Eunice Ola-Davies, James Olukayode Olopade, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah
Abstract Purpose Anacardium occidentale commonly known as Cashew is a plant that is widely used in African traditional medicine. It is endowed with phytochemical constituents that are responsible for its medicinal properties. Methods Twenty-five male Wistar rats were grouped as follows: Control (Group A), Group B (L-NAME 40 mg/kg), Group C (100 mg/kg Anacardium occidentale extract plus 40 mg/kg L-NAME)