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Clinical usefulness of a host signature based on TRAIL, IP10, and CRP (MeMed BV) as infection biomarkers in intensive care units’ patients. A retrospective observational study Clin. Biochem. (IF 2.8) Pub Date : 2024-03-13 Karol P. Steckiewicz, Magdalena A. Wujtewicz, Michał Okrągły, Aleksander Aszkiełowicz, Malgorzata Dąbrowska, Radosław Owczuk
Infection complications are common in intensive care unit patients, and early detection remains a diagnostic challenge. Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers. A novel diagnostic approach focuses on the host immune response. One of the novel approaches, the MMBV index, is based on measuring in a blood sample three parameters: (i) tumor necrosis factor-related
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Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay Clin. Biochem. (IF 2.8) Pub Date : 2024-03-12 Kwabena A.N. Sarpong, Su Hee Kim, Christopher R. McCartney, Joseph R. Wiencek, Lindsay A.L. Bazydlo
Immunoassays are important for routine clinical testing and medical diagnosis. However, they are limited by cross-reactivity especially at low analyte concentrations. There is a critical need to investigate compounds that can interfere with immunoassays. Herein, we describe the identification of canrenone, a spironolactone metabolite that falsely increases progesterone concentrations on the Abbott
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Autoimmune central nervous system disorders: Antibody testing and its clinical utility Clin. Biochem. (IF 2.8) Pub Date : 2024-03-08 Michael Gilligan, Christopher McGuigan, Andrew McKeon
A rapidly expanding repertoire of neural antibody biomarkers exists for autoimmune central nervous system disorders. Following clinical recognition of an autoimmune CNS disorder, the detection of a neural antibody facilitates diagnosis and informs prognosis and management. This review considers the phenotypes, diagnostic assay methodologies, and clinical utility of neural antibodies in autoimmune CNS
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Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α Clin. Biochem. (IF 2.8) Pub Date : 2024-03-08 Kayla Moehnke, Jennifer Kemp, Michelle R. Campbell, Ravinder J. Singh, Anne E. Tebo, Anthony Maus
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An association between plasma levels of α2-macroglobulin and α1-antitrypsin in PiMM and PiZZ individuals differing in COPD presentation Clin. Biochem. (IF 2.8) Pub Date : 2024-02-29 Urszula Lechowicz, Beatriz Martinez-Delgado, Bin Liu, Sabine Wrenger, Adriana Rozy, Aneta Zdral, David S. DeLuca, Tobias Welte, Sabina Janciauskiene, Joanna Chorostowska-Wynimko
Compared to normal PiMM, individuals with severe α1-antitrypsin (AAT) PiZZ (Glu342Lys) genotype deficiency are at higher risk of developing early-onset chronic obstructive pulmonary disease (COPD)/emphysema associated with Z-AAT polymers and neutrophilic inflammation. We aimed to investigate putative differences in plasma levels of acute phase proteins (APP) between PiMM and PiZZ subjects and to determine
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The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice Clin. Biochem. (IF 2.8) Pub Date : 2024-02-22 Ji Liu, Wenpeng Ni, Kunyi Deng, Yanhui Chen, Guanghong Gu
Multiple Acyl-CoA Dehydrogenase Deficiency (MADD), also known as Glutaric Aciduria Type II, is an exceptionally rare autosomal recessive genetic disorder that disrupts the metabolism of fatty acids, amino acids, and choline. It presents with a wide range of clinical manifestations, from severe neonatal-onset forms to milder late-onset cases, with symptoms including metabolic disturbances and muscle
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Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma Clin. Biochem. (IF 2.8) Pub Date : 2024-02-21 Maria Salinas, Emilio Flores, Alvaro Blasco, Maite Lopez-Garrigós, Ruth Torreblanca, María Leiva-Salinas, Irene Gutierrez, Carlos Leiva-Salinas, On behalf of the PRIMary Care-LABoratory (PRIMLAB) working group
Our objective was to shorten the screen for multiple myeloma (MM), through reflex testing. The clinical laboratory in the public University Hospital of San Juan (Alicante, Spain), serves 234,551 inhabitants. Through an intervention agreed with general practitioners, the Laboratory Information System (LIS) automatically registered serum immunoglobulins (Ig) when serum total proteins (STP) > 80 g/L for
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Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients Clin. Biochem. (IF 2.8) Pub Date : 2024-02-21 Abeer A. Alrefai, Mai A.H. Abouelenin, Maha M.A. Salman, Gehan A.E. Tawfeek, Mona A. Abbas
Growing evidence suggests that systemic lupus erythematosus (SLE), an organ-damaging systemic autoimmune illness, may be influenced by long-noncoding RNAs (lncRNAs). This study aimed to assess the relative expression of lncRNAs (MIR31HG, NKILA, and PACER) in patients with SLE to evaluate their role in the disease. This study involved 70 patients with SLE and 70 apparently healthy control subjects.
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Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke Clin. Biochem. (IF 2.8) Pub Date : 2024-02-17 Yuhan Dong, Bo Long, Zhanglin Tian, Junmeng Huang, Youdong Wei
Recently acquired data suggests that sodium-glucose cotransporter-2 (SGLT2) may be a therapeutic target for cerebral ischemia. The specific impact of SGLT2 in acute ischemic stroke (AIS) remains unknown. We aimed to explore the levels of SGLT2 in AIS patients and its association with functional prognosis. In this study, 132 AIS patients and 44 healthy controls were recruited prospectively to determine
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Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection Clin. Biochem. (IF 2.8) Pub Date : 2024-02-15 Ronstan Lobo, Laura De Michieli, Grant M. Spears, Elitza S. Theel, Leslie J. Donato, Amy M. Wockenfus, Brandon R Kelley, Allan S. Jaffe
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Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile Clin. Biochem. (IF 2.8) Pub Date : 2024-02-13 Peter A. Kavsak, Lorna Clark, Saranya Arnoldo, Amy Lou, Jennifer L. Shea, Shaun Eintracht, Andrew W. Lyon, Vipin Bhayana, Laurel Thorlacius, Joshua E. Raizman, Albert Tsui, Rose Djiana, Michael Chen, Yun Huang, Ali Haider, Ronald A. Booth, Chris McCudden, Paul M. Yip, Daniel Beriault, David Blank, Angela W.S. Fung, Jennifer Taher, Julie St-Cyr, Sameer Sharif, Emilie Belley-Cote, Beth L. Abramson, Steven
An analytical benchmark for high-sensitivity cardiac troponin (hs-cTn) assays is to achieve a coefficient of variation (CV) of ≤ 10.0 % at the 99th percentile upper reference limit (URL) used for the diagnosis of myocardial infarction. Few prospective multicenter studies have evaluated assay imprecision and none have determined precision at the female URL which is lower than the male URL for all cardiac
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The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity Clin. Biochem. (IF 2.8) Pub Date : 2024-02-10 Marwa A. Gaber, Omnia H.M. Omar, Abdel‑Raheim M.A. Meki, Ahmed Y. Nassar, Ayman K.M. Hassan, Marwan S. Mahmoud
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A call-to-action for energy conservation and sustainability in the clinical laboratory: Experiences from the University of Padova Clin. Biochem. (IF 2.8) Pub Date : 2024-02-08 Paola Galozzi, Laura Sciacovelli, Daniela Basso
Healthcare has a considerable environmental impact, yet it has been largely overlooked. Clinical laboratories, in particular, consume significantly more energy and water per unit area compared to standard office buildings. It is crucial to raise awareness among laboratories about the significance of embracing eco-friendly practices. Numerous energy-saving measures do not incur additional costs but
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Dose optimization and target attainment of vancomycin in children Clin. Biochem. (IF 2.8) Pub Date : 2024-02-05 Alessia Cafaro, Manuela Stella, Alessio Mesini, Elio Castagnola, Giuliana Cangemi, Francesca Mattioli, Giammarco Baiardi
Vancomycin is a glycopeptide antibiotic that has been adopted in clinical practice to treat gram-positive infections for more than 70 years. Despite vancomycin’s long history of therapeutic use, optimal dose adjustments and pharmacokinetic/pharmacodynamic (PK/PD) target attainment in children are still under debate. Therapeutic drug monitoring (TDM) has been widely integrated into pediatric clinical
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Elevated levels of β2-microglobulin in cerebrospinal fluid in adult patients with viral encephalitis/meningitis Clin. Biochem. (IF 2.8) Pub Date : 2024-02-03 Min-Zhi Zhang, Qi-Guang Shi, Xiao-Yi Xu, Yuan Qi, Lin-Jie Zhang, Ning Zhao, Jia Li, Li-Min Li, Li-Sha Sun, Li Yang
Increased cerebrospinal fluid (CSF) β2-microglobulin (β2-MG) values are attributed to immune activation, lymphoid cell turnover and release of tissue destruction in the central nervous system (CNS). We investigated plasma and CSF β2-MG levels in adult patients with viral encephalitis/meningitis and their correlations with clinical parameters. CSF samples from 26 patients with viral encephalitis/meningitis
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Preparing for another Ebola Outbreak: The impact of viral inactivation methods on commonly measured biochemistry analytes in plasma and urine Clin. Biochem. (IF 2.8) Pub Date : 2024-01-17 Janet Zhou, Franceska Sevilleno, Fari Rokhforooz, Jennifer Taher
Introduction Infectious specimens containing viruses like Ebola require sample manipulation to ensure the safety of laboratory staff, which may negatively impact biochemistry test results. We evaluated the impact of viral inactivation methods on 25 biochemistry analytes in plasma, and seven biochemistry analytes in urine. Methods Fifteen lithium heparinized plasma specimens with and without gel underwent
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Significance of SDC2 and NDRG4 methylation in stool for colorectal cancer diagnosis Clin. Biochem. (IF 2.8) Pub Date : 2024-01-13 Lu Long, Qian Sun, Fang Yang, Hui Zhou, Yu Wang, Changhe Xiao, Qing He, Bin Yi
Background Recent studies have identified methylated SDC2 and NDRG4 in colorectal cancer (CRC), however, the diagnostic value of the combined two genes remains undefined. This study aims to investigate the methylation of SDC2 and NDRG4 in stool samples and their application in diagnosis of CRC. Methods Five groups were enrolled in our study which consisted of CRC (n = 138), advanced adenomas (n = 27)
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Integrating patient-based quality control and patient-based quality assurance Clin. Biochem. (IF 2.8) Pub Date : 2024-01-11 Tony Badrick, Tze Ping Loh
Abstract not available
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Rapid and simple quantification of belimumab in human plasma using ultra-high performance liquid chromatography with tandem mass spectrometry Clin. Biochem. (IF 2.8) Pub Date : 2024-01-03 Chisato Yoshijima, Yosuke Suzuki, Ryota Tanaka, Hiroyuki Ono, Ayako Oda, Takashi Ozaki, Hirotaka Shibata, Hiroki Itoh, Keiko Ohno
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Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy Clin. Biochem. (IF 2.8) Pub Date : 2024-01-03 Emilia Hoste, Vincent Haufroid, Louise Deldicque, Jean-Luc Balligand, Laure Elens
Atorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current
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Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected Clin. Biochem. (IF 2.8) Pub Date : 2023-12-27 Jari Intra, Silvia Ippolito, Franco Lorenzini, Antonio Mauro, Maria Concetta Mazzitello, Stefano Melzi, Adele Cappellani, Fabrizio Cappellini, Marco Casati
Abstract not available
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Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing Clin. Biochem. (IF 2.8) Pub Date : 2023-12-28 Li Zhang, Xiang Dong, Yuling Zhan, Shasha Ma, Chuanmiao Liu, Yu Gao
Introduction and objective Decompensated cirrhosis (DCC) is a more advanced stage of liver cirrhosis (LC). It is important to identify biomarkers to predict DCC progression. The aim of this study was to analyze microRNA (miRNA) profiles of whole blood involved in the DCC process to gain a better understanding of the molecular mechanisms underlying its development. Materials and methods RNA-Seq analysis
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A systematic review of metabolomic findings in adult and pediatric renal disease Clin. Biochem. (IF 2.8) Pub Date : 2023-12-12 Lennart Moritz, Anke Schumann, Martin Pohl, Anna Köttgen, Luciana Hannibal, Ute Spiekerkoetter
Chronic kidney disease (CKD) affects over 0.5 billion people worldwide across their lifetimes. Despite a growingly ageing world population, an increase in all-age prevalence of kidney disease persists. Adult-onset forms of kidney disease often result from lifestyle-modifiable metabolic illnesses such as type 2 diabetes. Pediatric and adolescent forms of renal disease are primarily caused by morphological
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A verification and implementation plan for 50 blood gas analyzers across a large geographic area Clin. Biochem. (IF 2.8) Pub Date : 2023-12-06 Yury Butorin, Isolde Seiden-Long, Lawrence de Koning
Abstract not available
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Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy Clin. Biochem. (IF 2.8) Pub Date : 2023-12-02 Hou-Long Luo, Chen He, Hao Xue, Mingyang Li, Ling Ji, Yong Xia
Background Human epididymis protein 4 (HE4) is a promising tumor biomarker primarily utilized for the detection of ovarian cancer. However, its potential as a novel diagnostic indicator for immunoglobulin A nephropathy (IgAN) remains unknown. The objective of this study was to investigate the feasibility of serum HE4 as a novel biomarker for patients with IgAN. Methods This study enrolled a total of
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Development of a second-tier method for C4, C5 and C2 acylcarnitine analysis in plasma Clin. Biochem. (IF 2.8) Pub Date : 2023-12-02 Josko Ivica, Faisal Adam, Lyse Wortel, Teresa Kalika, Heather Pelly, Jeannette Gauthier, Murray Potter
Introduction Acylcarnitines are typically analyzed using either a flow injection analysis (FIA) method or liquid chromatography-mass spectrometry (LC-MS/MS) methods. The FIA method is a fast, efficient method, however it does not have the capability to separate compounds with the same molecular weight. These isobaric interferences can be removed by chromatographic separation with LC-MS/MS. In this
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Accuracy-based proficiency testing for estradiol measurements Clin. Biochem. (IF 2.8) Pub Date : 2023-12-01 Zhimin Tim Cao, Robert Rej, Hubert Vesper, J. Rex Astles
Objectives Accuracy of estradiol measurements is important but conventional proficiency testing (PT) cannot assess accuracy when possibly non-commutable samples are used and method peer-group means are the targets. Accuracy-based assessment of estradiol measurements is needed. Design and Methods Five serum samples were prepared from single donors, frozen, and distributed overnight to 76 New York State
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Comment on the article titled “Serum cystatin C is associated with peripheral artery stiffness in patients with type 2 diabetes mellitus combined with chronic kidney disease” Clin. Biochem. (IF 2.8) Pub Date : 2023-11-23 Mehmet Ilkin Naharci
Abstract not available
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Evaluation of the CKD-EPI 2021 creatinine equation using laboratory data: Considerations for practice changes among clinical laboratories in British Columbia, Canada Clin. Biochem. (IF 2.8) Pub Date : 2023-11-20 Roy Yu-Wei Chen, Junyan Shi
Introduction Clinical laboratories in British Columbia, Canada implemented the CKD-EPI 2009 equation without the race variable for estimated glomerular filtration rate (eGFR) reporting since 2014. As more clinical laboratories adopt the new CKD-EPI 2021 equation, the study aims to compare these two race-free CKD-EPI eGFR equations using the laboratory data from a large tertiary hospital in BC and evaluate
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The liver-heart axis in patients with severe obesity: The association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease Clin. Biochem. (IF 2.8) Pub Date : 2023-11-22 J. Young, K.A. Seeberg, K.M. Aakre, H. Borgeraas, N. Nordstrand, T. Wisløff, J. Hjelmesæth, T. Omland, J.K. Hertel
Background Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would be predictive of myocardial injury and fibrosis, expressed by higher concentrations of cardiac troponin T and I measured by high-sensitivity assays (hs-cTnT and hs-cTnI, respectively)
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Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions Clin. Biochem. (IF 2.8) Pub Date : 2023-11-19 Fei Peng, Lingling Wu, Jie Wu, Shuwei Duan, Jiayi He, Pu Chen, Peng Wang, Jiaona Liu, Guangyan Cai, Chuyue Zhang, Xiangmei Chen
Background Intrarenal arteriolar disease is a major risk factor for poor prognosis in immunoglobulin A nephropathy (IgAN). The morphologic factor sonic hedgehog (SHH) plays an important role in a variety of vascular diseases, so it may be directly or indirectly involved in the process of renal arteriolar disease. The purpose of this study was to investigate the correlation between serum SHH levels
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Lack of observed interference by therapeutic monoclonal antibodies in select commonly utilized immunoassays Clin. Biochem. (IF 2.8) Pub Date : 2023-11-14 Kornelia D. Galior, Paula M. Ladwig, Melissa R. Snyder, Alicia Algeciras-Schimnich, Joshua A. Bornhorst, Darci R. Block, Nikola A. Baumann, Maria Alice V. Willrich
Background Therapeutic monoclonal antibodies (tmabs) have been hypothesized to interfere with immunoassay measurements, although studies investigating this potential new class of interference are lacking. This study evaluated the effects of tmabs used in cancers ipilimumab (Bristol Myers Squibb), nivolumab (Bristol Myers Squibb), pembrolizumab (Merck) and autoimmune disorders adalimumab (AbbVie), infliximab
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Correlation between inflammatory biomarkers, cognitive function and glycemic and lipid profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis Clin. Biochem. (IF 2.8) Pub Date : 2023-11-07 Yage Du, Qi Zhang, Xiaolan Zhang, Ying Song, Jie Zheng, Yu An, Yanhui Lu
This study aimed to quantitatively estimate the correlation between systemic inflammation with cognitive function, as well as glycemic and lipid profiles in patients with type 2 diabetes mellitus (T2DM). The PubMed, Web of Science, EMBASE, SCOPUS, CNKI, Wanfang, VIP, and CBM databases were searched from its inception until June 2023 (PROSPERO registration: CRD42022356889). We analyzed data extracted
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Assessment of prognostic biomarkers in sudden sensorineural hearing loss: A systematic review and meta-analysis Clin. Biochem. (IF 2.8) Pub Date : 2023-11-07 Somayeh Niknazar, Narges Bazgir, Vahideh Shafaei, Hojjat-Allah Abbaszadeh, Alireza Zali, Ali Asghar Peyvandi
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Association of elevated extracellular HSP72 in albuminuria with systemic inflammation and disease progression in type 2 diabetic kidney disease Clin. Biochem. (IF 2.8) Pub Date : 2023-11-04 Kuppuswami Jayashree, Gandhipuram Periyasamy Senthilkumar, Sreejith Parameswaran, Mehalingam Vadivelan
Background Sub-clinical inflammation in hyperglycemia is tied to the pathogenesis of diabetic kidney disease (DKD). Though well known for its immunostimulatory function, the significance of extracellular heat shock protein 72 (eHSP72) in DKD is not well studied. We aimed to determine the association of extracellular HSP72 with systemic inflammation and the progression of DKD, and explore its possible
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Evaluation of commercial assays for the assessment of SARS-CoV-2 antibody response in hemodialysis patients Clin. Biochem. (IF 2.8) Pub Date : 2023-10-31 Ashley Di Meo, Liyan Ma, Kevin Yau, Kento T. Abe, Karen Colwill, Anne-Claude Gingras, Robert Kozak, Michelle A. Hladunewich, Paul M. Yip
Background Hemodialysis patients exhibit variable immunogenicity following administration of the SARS-CoV-2 mRNA vaccine. The aim of the current study was to evaluate the use of two commercial assays in the assessment of SARS-CoV-2 antibody response in hemodialysis patients and to compare their utility to commonly used SARS-CoV-2 serological assays developed in Canada. Methods We evaluated serologic
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Methods of the PivotaL triAl of the Atellica VTLi point of care emergencY dePartment high sensitivity troponin evalUationS Clin. Biochem. (IF 2.8) Pub Date : 2023-10-24 W. Frank Peacock, James L. Januzzi, Femke de Theije, Taylor Briseno, Gary Headden, Robert Birkhahn, Brandon R. Allen, Simon A. Mahler
Background The Atellica® VTLi point-of-care (POC) High Sensitivity Cardiac Troponin-I (hs-cTnI) assay is intended for use as an aid in the diagnosis of myocardial infarction (MI). Our primary objective is to assess its diagnostic performance in patients presenting with suspected acute coronary syndrome (ACS). Methods This prospective observational study will enrol ∼1500 patients at ∼20 U.S. Emergency
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Age specific reference intervals for plasma biomarkers of neurodegeneration and neurotrauma in a Canadian population Clin. Biochem. (IF 2.8) Pub Date : 2023-10-24 Jennifer G. Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T. Holmes, Cheryl L. Wellington
Introduction In this study, we aimed to create reference intervals (RI) using a large Canadian population-based cohort, for plasma protein biomarkers with potential utility to screen, diagnosis, prognosticate and manage a variety of neurological diseases and disorders. RIs were generated for: the ratio of amyloid beta 42 over 40 (Aβ42/40), phosphorylated tau-181 (p-tau-181), neurofilament light (NfL)
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Validating the NIH LDL-C equation for provincial implementation in Alberta Clin. Biochem. (IF 2.8) Pub Date : 2023-10-21 V. Higgins, L. Garcia, J.L. Gifford, N. Volodko, D.R. Beriault, M.L. Parker, M.P. Estey, D.T. Proctor, O.Z. Ismail
Background LDL-C, a cardiovascular disease risk assessment biomarker, is commonly calculated using the Friedewald equation. The NIH equation overcomes several limitations of the Friedewald equation. Consistent with the Canadian Society of Clinical Chemists (CSCC) lipid reporting recommendations, we assessed the NIH LDL-C equation in Alberta prior to its provincial implementation. Methods 1-year (0
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Do not report estimated average glucose (eAG) from HbA1c: Evidence is emerging Clin. Biochem. (IF 2.8) Pub Date : 2023-10-20 Yu Chen
Abstract not available
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Large method differences for free thyroid hormone assays in the hyperthyroid range can affect assessment of hyperthyroid status: Comparison of Abbott Alinity to Roche Cobas, Siemens Centaur and equilibrium dialysis LC-MS/MS Clin. Biochem. (IF 2.8) Pub Date : 2023-10-15 Alexander Bauer Westbye, Finn Erik Aas, Sandra R. Dahl, Svetlana N. Zykova, Oskar Kelp, Louise K. Dahll, Per M. Thorsby
Background Free T4 (FT4) determination is one of the most commonly performed biochemical tests in endocrinology. Treatment of thyroid dysfunctions is adjusted based on the severity of symptoms and biochemical test results. For Graves’ hyperthyroidism, clinical guidelines recommend using FT4 as a (rough) guide to dose antithyroid drugs, together with other clinical information. It is well known that
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Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure Clin. Biochem. (IF 2.8) Pub Date : 2023-10-14 Axel Muendlein, Christine Heinzle, Andreas Leiherer, Eva Maria Brandtner, Kathrin Geiger, Stella Gaenger, Peter Fraunberger, Arthur Mader, Christoph H. Saely, Heinz Drexel
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Methods for Determining Clinical Utility Clin. Biochem. (IF 2.8) Pub Date : 2023-10-14 Francis Bowling, Tony Badrick
Measuring the clinical utility of a diagnostic test involves evaluating its impact on patient outcomes, clinical decision-making, and healthcare resource utilization. Determining clinical utility requires accessing patient medical history and outcomes data. These studies involve enrolling patients undergoing diagnostic tests and tracking their clinical outcomes. Researchers can determine the test's
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Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023 Clin. Biochem. (IF 2.8) Pub Date : 2023-10-14
Abstract not available
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Clinical Utility - information about the usefulness of tests Clin. Biochem. (IF 2.8) Pub Date : 2023-10-04 Tony Badrick, Francis Bowling
The clinical utility of a diagnostic test refers to its usefulness in improving patient outcomes, informing clinical decision-making, and optimizing healthcare resources. A diagnostic test with high clinical utility provides accurate, reliable, and actionable information that can guide appropriate treatment decisions, monitor treatment response, and identify potential adverse events or complications
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Serum matrix metalloproteinase-9 (MMP9) and amyloid-beta protein precursor (APP) as potential biomarkers in children with Fragile-X syndrome: A cross sectional study Clin. Biochem. (IF 2.8) Pub Date : 2023-10-04 Mohamed H.Y. Bekheet, Lamiaa A. Mansour, Rasha H. Elkaffas, Mona A. Kamel, Mohamed A. Elmonem
Introduction Fragile-X syndrome(FXS) is a neurological disease caused by abnormal repeats in the 5′untranslated region of the FMR1 gene leading to a defective fragile-X-messenger-ribonucleoprotein-1 (FMRP). Although relatively common in children, it is usually under-diagnosed especially in developing countries where genetic screening is not routinely practiced. So far, FXS lacks a laboratory biomarker
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Reporting age-adjusted D-dimer cut-off values reduces radiology overuse in emergency department patients with suspected deep venous thrombosis Clin. Biochem. (IF 2.8) Pub Date : 2023-10-02 Pablo Leiva-Salinas, Emilio Flores, Alvaro Blasco, Ruth Torreblanca, Irene Gutierrez, Maite Lopez-Garrigós, Carlos Leiva-Salinas
Introduction Venous thromboembolism (VTE) is a leading cause of death, associated with substantial morbidity in the absence of treatment. Our aim was, first, to compare the diagnostic performance of D-dimer for the diagnosis of VTE in the emergency department (ED), when reporting conventional cut-off point versus when additionally reporting age-adjusted values. Second, we explored the ordering pattern
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A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer Clin. Biochem. (IF 2.8) Pub Date : 2023-10-02 Jianuo Yang, Zhenhua Chen, Jinxian He, Yikai Zhao, Chengwei Zhou, Xiaodong Zhao, Xiaodan Meng
Background Numerous studies have reported the vital roles of circular RNA (circRNA)-based competitive endogenous RNA (ceRNA) regulatory networks in cancers. Here, we established a non-small-cell lung cancer (NSCLC)-related circRNA–miRNA–mRNA axis and estimated its diagnostic value in NSCLC. Methods The circ_0061235–miR-3180-5p–PPM1L axis was constructed by small RNA deep sequencing, bioinformatics
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Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion Clin. Biochem. (IF 2.8) Pub Date : 2023-09-27 Yanqing Liu, Weina Huang, Jing Yang, Songbo Yuan, Congcong Li, Weiwei Wang, Zhigang Liang, Aihua Wu
Objective Pleural effusion (PE) is a common clinical complication associated with various disorders. We aimed to utilize laboratory variables and their corresponding ratios in serum and PE for the differential diagnosis of multiple types of PE based on a decision tree (DT) algorithm. Methods A total of 1435 untreated patients with PE admitted to The First Affiliated Hospital of Ningbo University were
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Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States Clin. Biochem. (IF 2.8) Pub Date : 2023-09-26 Jennifer Powers Carson, Jyoti Arora
Background and aims Multiple previously published studies have shown a weak to medium, negative correlation between BMI and glycated albumin (GA). However, many of these studies were in populations with a narrow range of BMI. It is unknown whether this trend exists if a wider BMI range is used. This is an important question for proper interpretation of GA levels in obese populations. Materials and
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Diagnostic accuracy of tumor M2-pyruvate kinase (tM2-PK) as a non-invasive biomarker in colorectal cancer: A systematic review and meta-analysis Clin. Biochem. (IF 2.8) Pub Date : 2023-09-25 Amir Hossein Aalami, Ali Shahriari, Mohammad Mazaheri, Farnoosh Aalami, Amir Amirabadi, Amirhossein Sahebkar
Introduction The tumor pyruvate kinase M2 isoform (tM2-PK) is a glycolytic enzyme isoform that is present on the surface of rapidly proliferating cancer cells. The objective of this investigation was to assess the efficacy of the tM2-PK measurement assay in detecting colorectal cancer (CRC) through the analysis of serum/plasma and stool samples obtained from patients. Methods The pooled diagnostic
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Artificial elevation of phosphatidylethanol due to red blood cell transfusion Clin. Biochem. (IF 2.8) Pub Date : 2023-09-23 Christine L.H. Snozek, Theresa N. Kinard, Kathy N. Alegria, Paul J. Jannetto, Loralie J. Langman
Introduction Phosphatidylethanol (PEth) is a marker of alcohol consumption used in clinical and forensic settings. PEth positivity in individuals expected to abstain from alcohol can have serious consequences. PEth is located on erythrocytes, thus packed red blood cell (pRBC) transfusion is a potential cause of false-positive results. This report is the first to demonstrate this phenomenon in an authentic
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Whole blood cytokine release assays reveal disparity between capillary blood sampling methods Clin. Biochem. (IF 2.8) Pub Date : 2023-09-22 Rhys T. Meredith, Ross A.R. Yarham, Hayley Mills, Maria A. Oliver
Introduction The use of whole blood in rapid cytokine release assays (CRAs) is becoming an established technique for screening immune responses following natural infection or vaccination, especially in the context of the SARS-CoV-2 pandemic. Establishing an accurate capillary blood sampling method to replace the need for venipuncture could make CRAs more accessible. In this study, capillary blood was
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Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer Clin. Biochem. (IF 2.8) Pub Date : 2023-09-22 Zhen Wang, Juan Ding, Yilei Xiao, Ke Xiao, Ping Su, Zhaogang Dong, Yi Zhang
Background Messenger RNAs (mRNAs) in serum extracellular vesicles (EVs) are effective non-invasive biomarkers for various types of cancer, however, their role as biomarkers for gastric cancer is yet to be investigated. Therefore, the current study was designed to explore their potential as novel biomarkers for gastric cancer. Methods The mRNAs in serum EVs from four patients with gastric cancer and
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Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study Clin. Biochem. (IF 2.8) Pub Date : 2023-09-20 Simon Faubert, Martine Paquette, Alexis Baass, Sophie Bernard
Background Statin and ezetimibe represent the first line of lipid-lowering therapy in patients with familial hypercholesterolemia (FH), a disease associated with a strong cardiovascular risk. The current low-density lipoprotein cholesterol (LDL-C) target achievement rate in a real-world context using these conventional treatments has never been investigated in the Province of Quebec (Canada). Objective
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Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria Clin. Biochem. (IF 2.8) Pub Date : 2023-09-19 Masayuki Sato, Yuka Nishibata, Sakiko Masuda, Tsunehisa Nagamori, Emi Ishibazawa, Yoichiro Yoshida, Hironori Takahashi, Akihiro Ishizu, Satoru Takahashi
Background Anti-glomerular basement membrane (anti-GBM) antibody is essential for the diagnosis of anti-GBM disease. The major epitope consists of the α3 subunits of type IV collagen non-collagenous domain (α 3(IV)NC1). There have been only a few reports of patients false-positive for anti-GBM antibody. Case Report We experienced an 8-year-old boy who presented with asymptomatic hematuria followed
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Establishing acceptable variation between instruments with dry chemistry methodology Clin. Biochem. (IF 2.8) Pub Date : 2023-09-19 Peter A. Kavsak, Rahim Ahmed, Leesa Lillie, Nadia Caruso
Abstract not available
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Utility of human epididymis protein 4 in the differential diagnosis of ascites Clin. Biochem. (IF 2.8) Pub Date : 2023-09-09 Silvia Bérgamo, Jaume Trapé, Laura González-García, Carolina González-Fernández, Carme Vergara, Noelia de-la-Torre, Glòria Trujillo, Dolors Estivill, Marco Antonio Álvarez-González, Laia Bosch, Marta Otero-Viñas, Carmen Bergós, Silvia Catot, Domingo Ruiz-Hidalgo, Sandra Ros, Francesc Sant
Background and aims Human epididymal protein 4 (HE4) may be a useful tool in the differential diagnosis of malignant ascites. The aim of this study was to evaluate the diagnostic utility of HE4 for detecting malignant ascites, taking into account the possible false positives identified with adenosine deaminase (ADA), C-reactive protein (CRP), % polynuclear cells (%PMN) and glomerular filtration rate