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The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci Open Med. (IF 2.1) Pub Date : 2024-03-15 Jie Wei, Yujie Li, Wenqian Zhou, Xiaoya Ma, Jie Hao, Ting Wen, Bin Li, Tianbo Jin, Mingjun Hu
Backgrounds Glioma is a highly malignant brain tumor with a grim prognosis. Genetic factors play a role in glioma development. While some susceptibility loci associated with glioma have been identified, the risk loci associated with prognosis have received less attention. This study aims to identify risk loci associated with glioma prognosis and establish a prognostic prediction model for glioma patients
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Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study Open Med. (IF 2.1) Pub Date : 2024-03-15 Yuan Liu, Yujian Miu, Ningjie Zhang, Wenhao Yu, Yu Chen, Jianli Zhang, Bo Zhang
Introduction Although the correlation between childhood obesity and coronavirus disease 2019 (COVID-19) has been explored, the causality of these remains uncertain. Thus, we conducted a two-sample Mendelian randomization (MR) analysis to identify the causal association. Methods Instrumental variables of childhood obesity were selected from genome-wide association study involving 61,111 Europeans. Besides
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A narrative review on adverse drug reactions of COVID-19 treatments on the kidney Open Med. (IF 2.1) Pub Date : 2024-03-15 Fatemeh Jahanshahi, Seyed Behnam Jazayeri, Mohammad Mirahmadi Eraghi, Leonardo Oliveira Reis, Mahtab Hamidikia, Shayan Amiri, Seyed Mohammad Kazem Aghamir
Studies showed that the respiratory is not the only system affected by coronavirus 2, while cardiovascular, digestive, and nervous systems, as well as essential organs such as the kidneys, can be affected by this virus. In this review, we have studied the epidemiology, clinical, and laboratory findings on COVID-19 infection renal involvement, mortality, physiopathology, remaining renal sequels after
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Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke Open Med. (IF 2.1) Pub Date : 2024-03-13 Meini Zhang, Xiao Hu, Tao Wang, Xianghong Liu
Objective To explore the efficacy of ginkgo diterpene lactone (GDLM) on cognitive function in patients with acute ischemic stroke (AIS). Methods A total of 126 patients with AIS in Shaanxi Provincial People’s Hospital from July 2019 to December 2020 were collected and randomly divided into the control group and treatment group (n = 63). All patients received conventional treatment, on which 25 mg/day
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Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer Open Med. (IF 2.1) Pub Date : 2024-03-13 Caixian Song, Liping Chen
Circular RNAs (circRNAs) are key regulators of cervical cancer (CC) progression. This study aimed to elucidate the role and mechanism of circ_0051428, a novel circRNA, in CC tumorigenesis. Quantitative real-time polymerase chain reaction and western blotting analyses confirmed that circ_0051428 and matrix metalloprotein-2 (MMP2) were overexpressed in CC, whereas the microRNA miR-885-3p was poorly expressed
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Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy Open Med. (IF 2.1) Pub Date : 2024-03-12 Baohua Li, ZhiLe Wu, Haofeng Xu, HuiLing Ye, Xin Yang
LncRNA XLOC_032768 is reported to prevent renal tubular epithelial cells from cisplatin-induced apoptosis, suggesting its involvement in the development of kidney injury. The present study aimed to explore the role of XLOC_032768 in diabetic nephropathy (DN). The present study enrolled a total of 140 healthy controls (Control group) and 140 patients with type 2 diabetes (Diabetes group). Expression
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The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis Open Med. (IF 2.1) Pub Date : 2024-03-08 Felix Busch, Katja N. De Paepe, Paul Gibbs, Michael Allison, Matthew Hoare, Teik Choon See
The role of hepatic venous pressure gradient (HVPG) measurement in risk stratification before liver resection is an ongoing area of debate. This study examines the impact of preoperative HVPG levels on overall survival (OS)/time to recurrence (TTR) and postoperative complications after hepatic resection of hepatocellular carcinoma (HCC). Thirty-eight HCC patients undergoing HVPG measurement before
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Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis Open Med. (IF 2.1) Pub Date : 2024-03-08 Fang Ling, Qiang Jianling, Wang Maofeng
As there are no predictive models for pulmonary embolism (PE) in patients with suspected PE at cardiology department. This study developed a predictive model for the probability of PE development in these patients. This retrospective analysis evaluated data from 995 patients with suspected PE at the cardiology department from January 2012 to December 2021. Patients were randomly divided into the training
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Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis Open Med. (IF 2.1) Pub Date : 2024-03-05 Yan Huang, Yuzhen Zhou, Huixian Chen, Yanyi Xu
This study aimed to investigate the changes of serum carbohydrate antigen 125 (CA125) and prostaglandin E2 (PGE2) in patients with adenomyosis before and after treatment with high-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone agonist (GnRH-a). One hundred and sixty-five patients with adenomyosis who received HIFU combined with GnRH-a were selected as case group. Sixty-five
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XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis Open Med. (IF 2.1) Pub Date : 2024-03-04 Shengke He, Xiujuan Zhao, Ruifang Mu, Zhongjun Pan, Jinglan Mai
Endometrial carcinoma’s (EC) etiology is complex and involves DNA repair gene polymorphisms like XRCC1-Arg399Gln and hOGG1-Ser326Cys, but their association with the disease is unclear. Following PRISMA, we conducted a systematic review and meta-analysis, collecting data from four databases. The studies needed to be population-based case–control studies examining the association between the named polymorphisms
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Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy Open Med. (IF 2.1) Pub Date : 2024-03-04 Shao-kang Wang, Xiao-ting Zhang, Xuan-yao Jiang, Bi-jiang Geng, Tao-lin Qing, Lei Li, Yun Chen, Jin-feng Li, Xiao-fang Zhang, Shuo-gui Xu, Jiang-bo Zhu, Yu-ping Zhu, Mei-tang Wang, Ji-kuai Chen
Photothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal tissues. Piezo1 might be a promising novel photothermal therapeutic target for breast cancer. This study aims to explore the potential role of Piezo1
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Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma Open Med. (IF 2.1) Pub Date : 2024-03-04 Yu Li, Miao-xuan Chen, Hai-tao Li, Xiao-ming Cai, Bo Chen, Ze-feng Xie
Pancreatic adenocarcinoma (PAAD) is a prevalent and aggressive malignancy in the digestive tract, requiring accurate prediction and effective treatment strategies. Recently, the discovery of disulfidptosis, a novel form of programmed cell death characterized by abnormal disulfide accumulation, has sparked interest in its role in PAAD. In this study, we aimed to investigate the involvement of disulfidptosis-related
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The analyses of human MCPH1 DNA repair machinery and genetic variations Open Med. (IF 2.1) Pub Date : 2024-02-29 Oluwafemi G. Oluwole
Causal mutations in the MCPH1 gene have been associated with disorders like microcephaly, and recently congenital hearing impairment. This study examined the MCPH1 DNA repair machinery and identified genetic variations of interest in gnomAD database to discuss the biological roles and effects of rare variants in MCPH1-related diseases. Notably, MCPH1 coordinates two of the seven known mechanisms of
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miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization Open Med. (IF 2.1) Pub Date : 2024-02-29 Zhengzheng Ju, Fan Cui, Zheng Mao, Zhen Li, Xiayu Yi, Jingjing Zhou, Jinjin Cao, Xiaoqin Li, Zengkun Qian
Previous studies have found that miR-335 is highly expressed in type II diabetes mellitus (T2DM) models and is related to insulin secretion, but there are few studies on the regulatory effects of miR-335-3p on insulin resistance and macrophage polarization in T2DM patients. This study aims to explore the effects of miR-335-3p on insulin resistance and macrophage polarization in T2DM patients. Blood
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Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement Open Med. (IF 2.1) Pub Date : 2024-02-28 Yu Mao, Yang Liu, Yanyan Ma, Mengen Zhai, Lanlan Li, Ping Jin, Jian Yang
In the study of TAVR, 3-dimensional (3D) printed aortic root models and pulsatile simulators were used for simulation training and teaching before procedures. The study was carried out in the following three parts: (1) experts were selected and equally divided into the 3D-printed simulation group and the non-3D-printed simulation group to conduct four times of TAVR, respectively; (2) another 10 experts
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Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay Open Med. (IF 2.1) Pub Date : 2024-02-13 Nils Lahmann, Martha Feh Mayer, John Posnett
Objective Hospital-acquired pressure ulcers are an important indicator of the quality of care. Most pressure ulcers are avoidable with a robust protocol for prevention, but prevention activities often have a low priority for senior management because the true costs to the hospital are not visible. Our aim was to raise awareness of the value of pressure ulcer prevention by estimating the excess length
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Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity Open Med. (IF 2.1) Pub Date : 2024-02-13 Guojin Liang, Jie Fang, Pingping Zhang, Shuxia Ding, Yudan Zhao, Yueying Feng
This study investigated how Metformin (Met) combined with L-carnitine (L-car) modulates brown adipose tissue (BAT) to affect obesity. High-fat-induced obese rats received daily oral gavage with Met and/or L-car, followed by serum biochemical analysis, histopathological observation on adipose tissues, and immunochemistry test for the abdominal expression of BAT-specific uncoupling protein 1 (UCP1).
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Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound Open Med. (IF 2.1) Pub Date : 2024-02-13 Rong Li, Liugui Lu, Zhaoxi Huang, Yong Gao
The purpose of this study was to investigate whether doxorubicin nanobubbles (DOX-NB) combined with diagnostic ultrasound (DUS) irradiation could downregulate the expression of carbonic anhydrase IX (CAIX) in mouse xenograft nasopharyngeal carcinoma (NPC) model. In this study, the prepared DOX-NB was round and well dispersed. The average diameter of DOX-NB was 250.9 ± 50.8 nm, with an average polydispersity
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Complete heart block associated with hepatitis A infection in a female child with fatal outcome Open Med. (IF 2.1) Pub Date : 2024-02-09 Mansoor Ahmed, Haseena Naseer, Mohammad Ebad ur Rehman, Jawad Basit, Abdulqadir J. Nashwan, Mateen Arshad, Afnan Ahmad, Muhammad Asad
Hepatitis A virus (HAV) infection can cause extra-hepatic manifestations like myocarditis. An 8-year-old female with HAV infection presented with fever, abdominal pain, vomiting, and icterus. She developed viral myocarditis with complete AV dissociation on ECG and was treated with a temporary pacemaker, but her condition worsened, and she died. Hepatitis A viral infection can be associated with viral
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Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease Open Med. (IF 2.1) Pub Date : 2024-02-09 Li Lu, Mengyu Cheng
We aimed to investigate the changes in the levels of high-molecular-weight (HMW) adiponectin, adiponectin receptors, and cytokines in patients with chronic obstructive pulmonary disease (COPD), as well as their potential relationships. Forty-one patients who underwent lobectomy for lung lesions and had a clear postoperative pathological diagnosis were divided into the non-COPD (N = 23) and COPD (N
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Cutaneous signs of selected cardiovascular disorders: A narrative review Open Med. (IF 2.1) Pub Date : 2024-02-09 Marium Asif, Muhammad Hamza Yousuf, Usman Shakeel Farooqui, Abdulqadir J. Nashwan, Irfan Ullah
Cardiovascular diseases are the leading cause of mortality and morbidity globally. Clinicians must know cutaneous signs of cardiovascular disease, including petechiae, macules, purpura, lentigines, and rashes. Although cutaneous manifestations of diseases like infectious endocarditis and acute rheumatic fever are well established, there is an indispensable need to evaluate other important cardiovascular
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Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis Open Med. (IF 2.1) Pub Date : 2024-02-09 Zijian Chen, Yangqi Liu, Zeying Lin, Weizhe Huang
Advances in lung cancer research applying machine learning (ML) technology have generated many relevant literature. However, there is absence of bibliometric analysis review that aids a comprehensive understanding of this field and its progress. Present article for the first time performed a bibliometric analysis to clarify research status and focus from 2010 to 2021. In the analysis, a total of 2
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Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma Open Med. (IF 2.1) Pub Date : 2024-02-09 Lin Chen, Gaofeng Tao, Mei Yang
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and belongs to the category of malignant tumors of the thyroid gland. Autophagy plays an important role in PTC. The purpose of this study is to develop a novel diagnostic model using autophagy-related genes (ARGs) in patients. In this study, RNA sequencing data of PTC samples and normal samples were obtained from GSE33630 and
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METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients Open Med. (IF 2.1) Pub Date : 2024-02-07 Quandan Tan, Le Yang, Shanshan Yuan, Danni Zheng, Yapeng Lin, Kejie Chen, Ying He, Shuntian Chen, Junli Hao, Jin Dai, Song He, Fengkai Mao, Xinyi Leng, Haisong Jiang, Jie Yang
Background N6-methyladenosine (m6A) is the most frequently occurring interior modification in eukaryotic messenger RNA (mRNA), and abnormal mRNA modifications can affect many biological processes. However, m6A’s effect on the metabolism of antiplatelet drugs for the prevention of ischemic stroke (IS) remains largely unclear. Methods We analyzed the m6A enzymes and m6A methylation in peripheral blood
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Aflatoxin B1 induces infertility, fetal deformities, and potential therapies Open Med. (IF 2.1) Pub Date : 2024-01-26 Sullibie Francis, Nii Korley Kortei, Marian Sackey, Seidu A. Richard
Aflatoxin B1 (AFB1) is a subsidiary poisonous metabolite, archetypally spawned by Aspergillus flavus and A. parasiticus, which are often isolated in warm or tropical countries across the world. AFB1 is capable of disrupting the functioning of several reproductive endocrine glands by interrupting the enzymes and their substrates that are liable for the synthesis of various hormones in both males and
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Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue Open Med. (IF 2.1) Pub Date : 2024-01-23 Shujia Lin, Shun Chen, Qiuping Lin, Tingting Xiao, Cuilan Hou, Lijian Xie
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a hereditary heart disease characterized by bidirectional or polymorphic ventricular tachycardia and an increased risk of sudden cardiac death. Although trans-2,3-enoyl-CoA reductase like (TECRL) is a newly reported pathogenic gene leading to CPVT that can influence intracellular calcium regulation, the unidentified mechanism underlying
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Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report Open Med. (IF 2.1) Pub Date : 2024-01-19 Hongling Li, Yang He, Yongying Wang, Mengwei Xu
Multicentric Castleman disease (MCD) is a heterogeneous, life-threatening disease. A subgroup of HIV-negative and HHV-8-negative MCD is defined as idiopathic MCD (iMCD) with a poor prognosis. Here we report an unusual case of a 47-year-old male patient with iMCD who experienced multiple treatment regimens such as chemotherapy, immunomodulatory therapy, and targeted therapy, all of which were considered
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Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma Open Med. (IF 2.1) Pub Date : 2024-01-16 LiPing Wu, JianPing He, YuQing Zheng, Yang Li
Purpose To compare target area delineation schemes in intensity-modulated radiotherapy (IMRT) effect on patients with locally advanced nasopharyngeal carcinoma (NPC). Methods A total of 88 NPC patients received IMRT and were assigned into control group (n = 44) and observation group (n = 44) based on MRI and CT imaging. In the control group, the treatment range was determined as the clinical target
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Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction Open Med. (IF 2.1) Pub Date : 2024-01-13 ChaoYing Liang, CuiYan Huang, ZhenRu Nong, SongLiang Li, MinShi Lin, ZuYe Qin
This study investigated the relationship between ATP-binding cassette sub-family B member 1 (ABCB1) and OLIG2 single nucleotide polymorphism (SNP) and neurological injury severity and outcome in cerebral infarction (CI). The neurological injury severity of 298 CI patients was evaluated by the National Institutes of Health Stroke Scale. The prognosis of CI patients at 30 days after admission was evaluated
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Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps Open Med. (IF 2.1) Pub Date : 2024-01-12 Lei Mu, Gang Qiu
Purpose This study identified subtypes and prognostic signature of stage I and stage II gastric cancer based on neutrophil extracellular trap (NET)-related genes. Methods The gene expression data associated with stage I and stage II gastric cancer were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. NET-related genes were obtained from previous reference
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Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report Open Med. (IF 2.1) Pub Date : 2024-01-12 Jun Zhang, Yuming Zhou, Zhenzhou Zhong, Yan Lv, Xuying Yang, Xianghong Liu
Infection following inguinal hernia repair (IHR) is uncommon. Rational use of antibiotics can significantly improve the prognosis of patients. However, accurately identifying the pathogen involved is usually challenging. This case report describes a patient who developed intermittent fever after undergoing open preperitoneal tension-free repair of a bilateral inguinal hernia. The scrotal fluid specimen
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Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty Open Med. (IF 2.1) Pub Date : 2024-01-12 Wen-Yi Gong, Feng Zou, Xiao-Fang Yue, Chen-Guang Li, Jing-Yu Zhang, Kun Fan
This study aimed to compare the postoperative analgesic efficacy and motor recovery of a novel lumbar plexus block (LPB) with that of a femoral nerve block (FNB) after total knee arthroplasty (TKA). Forty patients who underwent TKA were randomised equally into an lumbar plexus and sciatic nerve (LS) group (receiving novel LPB) and an femoral and sciatic nerves (FS) group (receiving FNB). The assessed
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METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC Open Med. (IF 2.1) Pub Date : 2024-01-10 Peng Zhang, Su Wang, Yuanyuan Chen, Qingbo Yang, Jian Zhou, Wangfu Zang
s Overexpression of methyltransferase-like 3 (METTL3) is significantly correlated with the malignancy of lung cancer (LC). In the present study, we demonstrated that METTL3 had higher levels in LC tissues relative to normal tissues. METTL3 showed superior sensitivity and specificity for diagnosis and identification of LC functions. In addition, silencing METTL3 resulted in enhanced ferroptosis sensitivity
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Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis Open Med. (IF 2.1) Pub Date : 2024-01-10 Basar Cander, Emin Fatih Visneci, Osman Karaoglan, Fatma Cakmak, Alpay Tuncar, Bahadir Taslidere
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. There is a need for biomarkers that can be used for the diagnosis of sepsis and the early identification of patients at high risk of death. In this study, we aimed to investigate the relationship between Mid-regional pro-adrenomedullin (MR-proADM), procalcitonin (PCT), and copeptin in sepsis
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The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma Open Med. (IF 2.1) Pub Date : 2024-01-09 Wenjing Chen, Jun Cheng, Yiqi Cai, Pengfei Wang, Jinji Jin
Background Dedifferentiated liposarcoma (DDL), a member of malignant mesenchymal tumors, has a high local recurrence rate and poor prognosis. Pyroptosis, a newly discovered programmed cell death, is tightly connected with the progression and outcome of tumor. Objective The aim of this study was to explore the role of pyroptosis in DDL. Methods We obtained the RNA sequencing data from The Cancer Genome
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Sirolimus potentiated angioedema: A case report and review of the literature Open Med. (IF 2.1) Pub Date : 2024-01-09 Hadi Beaini, Carol Bjorkman, Kelly Johnson, Faris G. Araj
Introduction In the realm of organ transplantation, particularly heart transplantation, angioedema presents a significant challenge. This clinical condition ranges from minor facial edema to life-threatening swelling of vital structures. Its multifactorial etiology involves various factors and mechanisms, including C1 esterase inhibitor deficiency, food allergen hypersensitivity, and adverse drug reactions
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STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis Open Med. (IF 2.1) Pub Date : 2024-01-06 Qiang Zou, Bo Tang, Xianchao Chen, Chuang Zhang, Yun Huang
Serine/threonine kinase 11 (STK11), a tumor suppressor gene, exhibits frequent mutations in lung adenocarcinoma (LUAD). However, the specific molecular mechanisms by which STK11 mutations exert an influence on the biosynthesis of monounsaturated fatty acids (MUFAs) and subsequently affect ferroptosis in LUAD remain indistinct. In this study, bioinformatic analysis was employed to probe into the linkage
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Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population Open Med. (IF 2.1) Pub Date : 2024-01-06 Na He, Aiwen Hong, Kun Zhao, Zhefan Zhang, Shengli Wang, Yaofei Jia
Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (SNPs) and KBD risk for the first time. In the case–control study, 735 unrelated Chinese Han individuals were enrolled. The four mutation sites of
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EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway Open Med. (IF 2.1) Pub Date : 2024-01-04 Xun Li, Bide Liu, Shuheng Wang, Qiang Dong, Jiuzhi Li
Prostate cancer (PCa) represents a substantial global health concern and a prominent contributor to male cancer-related mortality. The aim of this study is to explore the role of B-type endothelin receptor (EDNRB) in PCa and evaluate its therapeutic potential. The investigation employed predictive methodologies encompassing data acquisition from the GEO and TCGA databases, gene screening, enrichment
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miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor Open Med. (IF 2.1) Pub Date : 2023-12-26 Hui Kang, Jie Luo, Chun Wang, Yinghui Hong, Mingliang Ye, Yang Ding, Qiu Zhao, Ying Chang
The activation of hepatic stellate cells (HSCs) is regarded as the primary driving factor of liver fibrosis. miR-192, a miRNA associated with hepatocellular carcinoma and enriched in HSCs, has an undisclosed role in HSC activation and liver fibrosis. In this study, a CCl4-induced rat liver fibrosis model and transforming growth factor-beta 1 (TGF-β1)-treated HSC lines (LX-2 and HSC-T6) were used to
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Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway Open Med. (IF 2.1) Pub Date : 2023-12-26 Xiaopeng Cao, Hui Zhao, Zhimin Liang, Yi Cao, Min Min
Sepsis can impair gastrointestinal (GI) barrier integrity. Oral probiotics (PT) can maintain the balance of GI microflora and improve GI function. 5-Hydroxytryptamine (5-HT) is a key promoter of GI injury caused by sepsis. However, the mechanism by which PT attenuates sepsis by regulating 5-HT is not fully understood. In this study, C57BL6 mice were intragastric administrated with normal saline (NC)
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Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction Open Med. (IF 2.1) Pub Date : 2023-12-21 Yingchun Hu, Xiaoyu Chen, Xiyuan Mei, Zhen Luo, Hongguang Wu, Hao Zhang, Qingchun Zeng, Hao Ren, Dingli Xu
Post-myocardial infarction heart failure (HF) is a major public health concern. Previous studies have reported the critical role of immune response in HF pathogenesis. However, limited studies have reported predictive immune-associated biomarkers for HF. So we attempted to identify potential immune-related indicators for HF early diagnosis and therapy guidance. This study identified two potential immune-related
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Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units Open Med. (IF 2.1) Pub Date : 2023-12-21 Stevan Eric, Radica Zivkovic Zaric, Jasna Jevdjic, Svetlana Miletic Drakulic, Ivan Stanojevic, Danilo Vojvodic, Petar Arsenijevic, Bojan Stojanovic, Stefan Jakovljevic, Nenad Markovic, Milan Zaric, Petar Canovic, Jelena Nesic, Nenad Zornic
Intensive care units (ICUs) are expert hospital areas that provide treatment and 24 h care for people who are very sick. Sepsis represents a serious, severe condition and it can lead to septic shock and multiple organ dysfunction syndromes and is one of the most common reasons for patients’ hospitalization in ICUs. We wanted to explore the prognostic values of interleukin (IL) 33, soluble suppression
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Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes Open Med. (IF 2.1) Pub Date : 2023-12-20 Xuefang Liu, Youyan Qiu, Dandan Chen, Jingni Xiong, Biwen Xia, Caiqin Chen, Suyan Li
The association of thyroid hormone antibodies and glycolipid metabolism indicators with Type 2 diabetes mellitus (T2DM) was explored. As the disease worsens, the levels of thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb), and thyroid-stimulating hormone (TSH) was increased, and the levels of total tri-iodothyronine (TT3) and total thyroxine (TT4) was decreased (P < 0.001). The severe
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The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study Open Med. (IF 2.1) Pub Date : 2023-12-20 Lei Pang, Zijun Ding, Hongqiang Chai, Weibing Shuang
Studies have suggested that the progress of most kidney diseases from occurrence to course and subsequent related complications are closely related to inflammatory reaction. Increased common leukocytes count in the family (neutrophils, eosinophils, basophils, lymphocytes, etc.) are also involved in the tissue damage of kidney diseases. However, these studies are only traditional observational studies
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The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer Open Med. (IF 2.1) Pub Date : 2023-12-20 Xinyu Cheng, Jianguo Xia, Qi Xu, Huawei Gui
This study aimed to explore the value of color Doppler ultrasonography combined with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in differential diagnosis of gastric stromal tumor (GST) and gastric cancer (GC). An analysis of the clinical data of 180 patients with clinically suspected gastric space occupying lesions. According to the postoperative pathological results, 180
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FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma Open Med. (IF 2.1) Pub Date : 2023-12-16 Yifan Deng, Kailiang Zeng, Diancheng Wu, Yunzhi Ling, Yu Tian, Yi Zheng, Shumin Fang, Xiaocong Jiang, Gang Zhu, Yanyang Tu
Glioma is the most common primary brain tumor. Filamin-binding LIM protein 1 (FBLIM1) has been identified in multiple cancers and is suspected of playing a part in the development of tumors. However, the potential function of FBLIM1 mRNA in glioma has not been investigated. In this study, the clinical information and transcriptome data of glioma patients were, respectively, retrieved from the TCGA
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ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi Open Med. (IF 2.1) Pub Date : 2023-12-16 Xiujuan Wu, Shuijuan Shen, Jiaying Wu, Shaorui Wu, Shimi Wang, Feng Di
This study aims to investigate the impact of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) on vascular calcification in rats. The rationale behind studying ENPP1’s role in vascular calcification lies in its potential to modulate calcification processes. Understanding this relationship can offer insights into novel therapeutic avenues for addressing vascular calcification-related disorders
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VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature Open Med. (IF 2.1) Pub Date : 2023-12-11 Ran Ren, Xin Chang, Cong Chen, Hao Yu, Lu Han
V-domain Ig suppressor of T cell activation (VISTA), encoded by the human VSIR gene, is a B7 family checkpoint homologous to the programmed death-Ligand 1 sequence. In gynecologic malignancies, VISTA is abnormally expressed and regulates the tumor immune microenvironment, causing a high upregulation of VISTA expression in T-cells and myeloid cells in the tumor microenvironment and promoting tumor proliferation
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Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia Open Med. (IF 2.1) Pub Date : 2023-12-07 Jing Wei, Jincheng Zhang, Yanan Shi, Huiqin Zhang, Yan Wu
Elevated serum uric acid (UA) level is related to type 2 diabetic retinopathy (DR). Vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and cystatin C (Cys-C) have involvement in type 2 DR complicated with hyperuricemia (HUA) (HUDR), and we explored their clinical values in HUDR. Type 2 DR patients were allocated into HUDR/DR groups, with type 2 diabetes mellitus
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Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis Open Med. (IF 2.1) Pub Date : 2023-12-07 Erika Di Zazzo, Sergio Davinelli, Serena Panichella, Giovanni Scapagnini, Mariano Intrieri, Silvio Garofalo
Studies on the COVID-19 pandemic effects on gestational diabetes mellitus (GDM) remain limited and controversial. This study aimed to investigate the impact of the COVID-19 lockdown on the glycemic balance of pregnant women and GDM risk. To this aim, a single-center retrospective cohort analysis assessing glucose homeostasis using the oral glucose tolerance test in 862 pregnant women before (from March
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Clinical features and management of lymphoepithelial cyst Open Med. (IF 2.1) Pub Date : 2023-12-07 Ning Cui, Wenhao Su, Jixiang Zhang, Zhongyin Zhou
The aim of the study was to analyze clinical features of lymphoepithelial cyst (LEC) to make a more comprehensive and deeper understanding of it. We retrospectively analyzed the hospital records of 201 patients who were diagnosed by pathology results. Clinical characteristics like demographic profiles, lesion characteristics, therapeutic schedule, and associated costs were analyzed. Patient’s age ranged
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A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women Open Med. (IF 2.1) Pub Date : 2023-12-06 Xinzhuan Jia, Lan Wei, Na Zhang, Bolin Zheng, Mengya Li, Hongxia Wang, Erhuan Liu, Jie Xu, Guangyu Sun, Zhengmao Zhang
In areas with high incidence of tuberculosis (TB), there are more infertile women who underwent in vitro fertilization (IVF) and have latent TB infection (LTBI), and thus, their potential risks should be paid enough attention. The purpose of our study aimed to analyze the relationship between LTBI and clinical pregnancy outcomes of IVF and fresh embryo transfer (IVF–FET). This was a retrospective study
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New insights into the prevention of ureteral stents encrustation Open Med. (IF 2.1) Pub Date : 2023-12-06 Hao Guo, Jun-Bin Yuan
Ureteral stents are commonly used medical devices for the treatment of urinary system diseases. However, while providing benefits to patients, they often give rise to various issues, with stent encrustation being a major concern for clinical physicians. This phenomenon involves the formation of attached stones on the stent’s surface, leading to potential complications such as increased fragility and
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Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience Open Med. (IF 2.1) Pub Date : 2023-12-06 Alaa Rahhal, Mostafa Najim, Ahmed Mahfouz, Mhd Baraa Habib, Sara Seife Hassen, Isra’a Al-Shekh, Ashraf Omer Ahmed, Haneen Toba, Shahem Abbarh, Mawahib El Hassan, Sumaya Al Yafei, Amr Badr, Khaled Mohamed Mahmoud
Sustained low-efficiency dialysis (SLED) is usually performed over 6–12 h among hemodynamically unstable patients. Conduction of 4-h SLED may spare time and manpower during hospitalization. Therefore, we conducted a retrospective observational study to explore the appropriateness and clinical outcomes of 4-h SLED among critically ill patients admitted to our center from 1/06/2016 to 1/06/2020. Renal
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miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD Open Med. (IF 2.1) Pub Date : 2023-12-06 Fangdong Lu, Huaping Gong, Linhai Duan, Yuan Yan, Long Chen, Pei Peng, Qiaoan Zhang, Wenrong Song, Jia Li
Previous studies have shown that microRNAs (miRNAs) are involved in the regulation of a variety of metabolic diseases, which related to some important signal pathways. Our aim was to explore the possible mechanism of miRNAs by revealing the differential expression of serum miRNAs in different BMI of type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). We found that
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Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation Open Med. (IF 2.1) Pub Date : 2023-11-30 Kuang-Ming Liao, Pei-Jun Chen, Chung-Yu Chen
Patients with chronic obstructive pulmonary disease (COPD) had higher risk of atrial fibrillation (AF). The treatment of AF includes medicines to control heart rate and reduce the risk of stroke, and procedures such as cardioversion to restore normal heart rhythm. To reduce the stroke, patients with AF may prescribe some type of antithrombotic medication (such as warfarin, one of the new non-vitamin
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METTL16 in human diseases: What should we do next? Open Med. (IF 2.1) Pub Date : 2023-11-30 Hui Zhang, Mengqi Yin, Hua Huang, Gongfang Zhao, Mingliang Lu
METTL16 is a class-I methyltransferase that is responsible for depositing a vertebrate-conserved S-adenosylmethionine site. Since 2017, there has been a growing body of research focused on METTL16, particularly in the field of structural studies. However, the role of METTL16 in cell biogenesis and human diseases has not been extensively studied, with limited understanding of its function in disease
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Predictors of gastrointestinal complaints in patients on metformin therapy Open Med. (IF 2.1) Pub Date : 2023-11-29 Branislava Raičević, Slobodan Janković
Although being very effective in the treatment of diabetes and a few other conditions, metformin (MTF) cannot be tolerated by many patients due to gastrointestinal (GI) complaints. A number of risk factors for intolerance were identified, but many are still controversial or uninvestigated. The aim of this study was to further investigate possible risk factors for the occurrence of GI complaints in
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Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids Open Med. (IF 2.1) Pub Date : 2023-11-29 Na Mi, Lili Ma, Xueying Li, Jia Fu, Xinxin Bu, Fei Liu, Fan Yang, Yali Zhang, Lifen Yao
The gut microbiota and microbial metabolites influence the enteric nervous system and the central nervous system via the microbial–gut–brain axis. Increasing body of evidence suggests that disturbances in the metabolism of peripheral branched-chain amino acids (BCAAs) can contribute to the development of neurodegenerative diseases through neuroinflammatory signaling. Preliminary research has shown