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Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2024-02-28 Leena M. Koskinen, Lari Nieminen, Antti Arjonen, Camilo Guzmán, Markus Peurla, Emilia Peuhu
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Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2024-02-10 Alicja Mazan, Anna A. Marusiak
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Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2024-01-30 Jenelys Ruiz Ortiz, Steven M. Lewis, Michael Ciccone, Deeptiman Chatterjee, Samantha Henry, Adam Siepel, Camila O. dos Santos
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Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2024-01-30 Sébastien Molière, Arthur Martinet, Amélie Jaulin, Massimo Lodi, Thien-Nga Chamaraux-Tran, Fabien Alpy, Guillaume Bierry, Catherine Tomasetto
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Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2024-01-13
Abstract Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made up of larger collecting vessels and smaller capillaries, has specialized cell junctions that facilitate cell intravasation. Normally, these junctions are designed to collect immune cells and other cellular components for immune surveillance by lymph nodes, but they are also
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Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-12-08 Baptiste Hamelin, Milan M. S. Obradović, Atul Sethi, Michal Kloc, Simone Münst, Christian Beisel, Katja Eschbach, Hubertus Kohler, Savas Soysal, Marcus Vetter, Walter P. Weber, Michael B. Stadler, Mohamed Bentires-Alj
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A molecular toolbox to study progesterone receptor signaling J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-11-29 Marleen T. Aarts, Muriel Wagner, Tanne van der Wal, Antonius L. van Boxtel, Renée van Amerongen
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Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-10-06 Silke Blair Chalmers, Tanne van der Wal, Silvia Fre, Jos Jonkers
The fourteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology and Breast Cancer was held on April 26th − 29th in Weggis, Switzerland. For the first time, early career researchers organised and took part in an additional ECR workshop on the 26th of April, which was received with great enthusiasm. The topics of the main workshop included
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High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-10-06 Wintana Balema, Janelle Morton, Richard A. Larson, Li Li, Fred Christian Velasquez, Natalie W. Fowlkes, Savitri Krishnamurthy, Bisrat G. Debeb, Eva Sevick-Muraca, Wendy A. Woodward
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Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-21 Adam P. Golding, Benjamin Ferrier, Laura A. New, Peihua Lu, Claire E. Martin, Erka Shata, Robert A. Jones, Roger A. Moorehead, Nina Jones
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Non-Linear Lymphatic Anatomy in Breast Cancer Patients Prior to Axillary Lymph Node Dissection: A Risk Factor For Lymphedema Development J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-22 JacqueLyn R. Kinney, Rosie Friedman, Erin Kim, Elizabeth Tillotson, Kathy Shillue, Bernard T. Lee, Dhruv Singhal
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Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-14 Renée van Amerongen, Mohamed Bentires-Alj, Antonius L. van Boxtel, Robert B. Clarke, Silvia Fre, Eva Gonzalez Suarez, Richard Iggo, Martin Jechlinger, Jos Jonkers, Marja L. Mikkola, Zuzana Sumbalova Koledova, Therese Sørlie, Maria dM. Vivanco
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Gestational Breast Cancer – a Review of Outcomes, Pathophysiology, and Model Systems J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-14 Mackenzie K. Callaway, Camila O. dos Santos
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Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals. J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-14 Katherine Hughes
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SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-04 Judith Seitz, Alan Bilsland, Chloé Puget, Ian Baasner, Robert Klopfleisch, Torsten Stein
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Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-07-01 Julia Ettlin, Alina Bauer, Lennart Opitz, Alexandra Malbon, Enni Markkanen
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PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-06-09 Romain J. Amante, Charly Jehanno, Duvini De Silva, Marie-May Coissieux, Markus Ackerknecht, Vincent Romanet, Atul Sethi, Baptiste Hamelin, Bogdan-Tiberius Preca, Salvatore Piscuoglio, Charlotte K. Y. Ng, Morvarid Mohseni, Mohamed Bentires-Alj
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Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-06-03 Mylena M.O. Ortiz, Eran R. Andrechek
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Longitudinal analysis of bovine mammary gland development J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-05-30 Alysia L. Vang, Tiago Bresolin, Waneska S. Frizzarini, Guilherme L. Menezes, Thiago Cunha, Guilherme J. M. Rosa, Laura L. Hernandez, Joao R. R. Dorea
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ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-05-23 Alessia Morato, Paolo Accornero, Russell C. Hovey
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FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-05-16 Kamil Mieczkowski, Marta Popeda, Dagmara Lesniak, Rafal Sadej, Kamila Kitowska
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Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-05-01 Ken Kobayashi
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The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-04-22 Hannah P Fricke, Laura L Hernandez
Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient calcium for the offspring in milk. The role of serotonin in bone remodeling was first discovered over two decades ago, and the interplay between serotonin, lactation
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Associations Between Dog Breed and Clinical Features of Mammary Epithelial Neoplasia in Bitches: an Epidemiological Study of Submissions to a Single Diagnostic Pathology Centre Between 2008–2021 J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-03-24 Grace Edmunds, Sam Beck, Kedar Umakant Kale, Irena Spasic, Dan O’Neill, David Brodbelt, Matthew J. Smalley
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Valine Treatment Enhances Antimicrobial Component Production in Mammary Epithelial Cells and the Milk of Lactating Goats Without Influencing the Tight Junction Barrier J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-02-18 Yusaku Tsugami, Takahiro Nii, Naoki Isobe
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Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-02-18 Alex Cordero, Patricia G. Santamaría, Eva González-Suárez
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Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2023-01-27 Patrice M. Witschen, Alexis K. Elfstrum, Andrew C. Nelson, Kathryn L. Schwertfeger
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Protein Expression of PI3K/AKT/mTOR Pathway Targets Validated by Gene Expression and its Correlation with Prognosis in Canine Mammary Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-11-02 Isabela F. S. Perossi, Mylena M. Saito, Giovanna Rossi Varallo, Bianca Lara Venâncio de Godoy, Jucimara Colombo, Debora A. P. C. Zuccari
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Thirteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-10-15 Alecia-Jane Twigger, Jakub Sumbal, Mohamed Bentires-Alj, Beatrice A Howard
The thirteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) Laboratories Annual Workshop took place on the 28–30 April 2022 in Weggis, Switzerland and focused on methods in mammary gland biology and breast cancer. Sixty scientists participated in the ENBDC annual workshop which had not been held in person since 2019 due to the global COVID-19 pandemic. Topics spanned
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Comparative Analysis of microRNAs that Stratify in vitro Mammary stem and Progenitor Activity Reveals Functionality of Human miR-92b-3p J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-10-03 James L. Miller, Matt Kanke, Gat Rauner, Kimaya M. Bakhle, Praveen Sethupathy, Gerlinde R. Van de Walle
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Comparative analysis of the molecular subtype landscape in canine and human mammary gland tumors J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-08-06 Helga Bergholtz, Tonje Lien, Frode Lingaas, Therese Sørlie
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Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-07-29 James L. Miller, Arianna P. Bartlett, Rebecca M. Harman, Prabin Dhangada Majhi, D. Joseph Jerry, Gerlinde R. Van de Walle
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Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-06-23 Romain J. Amante, Priska Auf der Maur, Veronica Richina, Atul Sethi, Vytautas Iesmantavicius, Debora Bonenfant, Nicola Aceto, Mohamed Bentires-Alj
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In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-06-13 Eric P. Souto, Lacey E. Dobrolecki, Hugo Villanueva, Andrew G. Sikora, Michael T. Lewis
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Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-06-09 Yusaku Tsugami, Naoki Suzuki, Takahiro Nii, Naoki Isobe
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Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-05-17 Haruka Wakasa, Yusaku Tsugami, Taku Koyama, Liang Han, Takanori Nishimura, Naoki Isobe, Ken Kobayashi
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Ductal Carcinoma in Situ: Molecular Changes Accompanying Disease Progression J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-05-14 Gemma M. Wilson, Phuong Dinh, Nirmala Pathmanathan, J. Dinny Graham
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CCND1 Amplification in Breast Cancer -associations With Proliferation, Histopathological Grade, Molecular Subtype and Prognosis J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-04-22 Marit Valla, Elise Klæstad, Borgny Ytterhus, Anna M. Bofin
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Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-03-03 Deyou Kong, Dongxing Shen, Zhikun Liu, Jun Zhang, Jian Zhang, Cuizhi Geng
Breast cancer is one of the most common malignancies worldwide. Circular RNAs (CircRNAs) were revealed to be implicated in the development of breast cancer. In this research, we aimed to investigate the role and underlying mechanism of circ_0008500 in the development and radiosensitivity of breast cancer. Using real-time quantitative PCR (RT-qPCR) and western blot, we found that hsa_circ_0008500 (circ_0008500)
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Chronic Leptin Treatment Induces Epithelial-Mesenchymal Transition in MCF10A Mammary Epithelial Cells J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-02-23 Juan Carlos Juárez-Cruz, Michal Okoniewski, Mónica Ramírez, Carlos Ortuño-Pineda, Napoleón Navarro-Tito, Eduardo Castañeda-Saucedo
Leptin is a cytokine-like hormone that functions as a link between obesity and breast cancer (BC). Leptin treatment induces Epithelial to Mesenchymal Transition (EMT) in BC cell lines. In non-tumoral breast epithelial MCF10A cells, acute leptin treatment induces partial EMT. However, the effect of chronic leptin treatment on EMT in non-tumorigenic breast cells has not been fully explored. This study
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Correction to: Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492. J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-12-01 Anna Karen Sigurdardottir,Arna Steinunn Jonasdottir,Arni Asbjarnarson,Hildur Run Helgudottir,Thorarinn Gudjonsson,Gunnhildur Asta Traustadottir
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Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-02-10 Yousra Ahmed ZeinElAbdeen, Amna AbdAlSeed, Rana A. Youness
Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue
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Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-02-09 Zach Carlson, Hannah Hafner, Noura El Habbal, Emma Harman, Stephanie Liu, Nathalie Botezatu, Masa Alharastani, Cecilia Rivet, Holly Reynolds, Nyahon Both, Haijing Sun, Dave Bridges, Brigid Gregg
Maternal health and diet can have important consequences for offspring nutrition and metabolic health. During lactation, signals are communicated from the mother to the infant through milk via macronutrients, hormones, and bioactive molecules. In this study we designed experiments to probe the mother-milk-infant triad in the condition of normal maternal health and upon exposure to high fat diet (HFD)
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A CD8+ T Cell-Related Genes Expression Signature Predicts Prognosis and the Efficacy of Immunotherapy in Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-01-27 Lian-hua Lv, Jia-rong Lu, Tao Zhao, Jing-li Liu, Hai-qi Liang
Immunotherapy has been applied to patients with breast cancer. However, only part of patients benefits from the current immunotherapy. Accurate prediction of individual response to immunotherapy can be beneficial for breast cancer management. CD8+ T cells are the main force of anti-tumor immunity. This study aimed to establish a CD8+ T cell-related gene expression signature for prediction of breast
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Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn) J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-01-26 Craig R. Baumrucker, Ann L. Macrina, Rupert M. Bruckmaier
Colostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly ending after birth in the bovine. It has been the focus of research to define what controls this process and how it produces high concentrations of specific biologically active components important for the neonate. In this review we consider colostrum composition
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Stromal Changes are Associated with High P4HA2 Expression in Ductal Carcinoma in Situ of the Breast J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-01-25 Agahozo, Marie Colombe, van Bockstal, Mieke, Westenend, Pieter J., Galant, Christine, Lambein, Kathleen, Reisenbichler, Emily, Sinke, Renata, Wong, Serena, van Deurzen, Carolien H. M.
Ductal carcinoma in situ (DCIS) of the breast is able to induce stromal changes, which likely reflect the crosstalk between DCIS and its microenvironment. These changes harbor prognostic information, although the interobserver variability of scoring stromal changes is moderate. A more robust evaluation of the DCIS-associated stroma is therefore needed. The aim of this study was to characterize P4HA2
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Local Heat Treatment of Goat Udders Influences Innate Immune Functions in Mammary Glands J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-01-11 Tsugami, Yusaku, Ishiba, Yuki, Suzuki, Naoki, Nii, Takahiro, Kobayashi, Ken, Isobe, Naoki
Heat stress and mastitis adversely affect milk production in dairy ruminants. Although the udder temperature is elevated in both conditions, the influence of this local temperature rise on milk production and immune function of ruminant mammary glands remains unclear. To address this question, we heated the mammary glands of goats by covering one half of the udder with a disposable heating pad for
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Altered Epithelial-mesenchymal Plasticity as a Result of Ovol2 Deletion Minimally Impacts the Self-renewal of Adult Mammary Basal Epithelial Cells J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2022-01-04 Sun, Peng, Han, Yingying, Plikus, Maksim, Dai, Xing
Stem-cell containing mammary basal epithelial cells exist in a quasi-mesenchymal transcriptional state characterized by simultaneous expression of typical epithelial genes and typical mesenchymal genes. Whether robust maintenance of such a transcriptional state is required for adult basal stem cells to fuel self-renewal and regeneration remains unclear. In this work, we utilized SMA-CreER to direct
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Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492 J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-12-28 Sigurdardottir, Anna Karen, Jonasdottir, Arna Steinunn, Asbjarnarson, Arni, Helgudottir, Hildur Run, Gudjonsson, Thorarinn, Traustadottir, Gunnhildur Asta
The human breast is composed of terminal duct lobular units (TDLUs) that are surrounded by stroma. In the TDLUs, basement membrane separates the stroma from the epithelial compartment, which is divided into an inner layer of luminal epithelial cells and an outer layer of myoepithelial cells. Stem cells and progenitor cells also reside within the epithelium and drive a continuous cycle of gland remodelling
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Nfatc1’s Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-12-21 McNeil, Melissa, Han, Yingying, Sun, Peng, Watanabe, Kazuhide, Jiang, Jun, Chen, Natasha, Yu, Zhengquan, Zhou, Bin, Dai, Xing
Mammary gland is an outstanding system to study the regulatory mechanisms governing adult epithelial stem cell activity. Stem cells in the basal layer of the mammary gland fuel the morphogenesis and regeneration of a complex epithelial network during development and upon transplantation. The self-renewal of basal stem/progenitor cells is subjected to regulation by both cell-intrinsic and extrinsic
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Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-12-16 Ward, Ashley V., Anderson, Steven M., Sartorius, Carol A.
Abnormal lipid metabolism is common in breast cancer with the three main subtypes, hormone receptor (HR) positive, human epidermal growth factor 2 (HER2) positive, and triple negative, showing common and distinct lipid dependencies. A growing body of studies identify altered lipid metabolism as impacting breast cancer cell growth and survival, plasticity, drug resistance, and metastasis. Lipids are
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Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-11-23 Rojas-Sanchez, Guadalupe, García-Miranda, Alin, Montes-Alvarado, José Benito, Cotzomi-Ortega, Israel, Sarmiento-Salinas, Fabiola Lilí, Jimenez-Ignacio, Eduardo Eleazar, Ramírez-Ramírez, Dalia, Romo-Rodríguez, Rubí Esmeralda, Reyes-Leyva, Julio, Vallejo-Ruiz, Verónica, Pazos-Salazar, Nidia Gary, Maycotte, Paola
Breast cancer (BC) is the leading cause of cancer-related death in women in the world. Since tumor cells employ autophagy as a survival pathway, it has been proposed that autophagy inhibition could be beneficial for cancer treatment. There are several onging clinical trials where autophagy is being inhibited (using chloroquine, CQ or hydroxychloroquine, HCQ) along with chemotherapy with promising results
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Evolution and Self-renewal of the Journal of Mammary Gland Biology and Neoplasia. J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-10-14 Russell C Hovey,Zuzana Koledova
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The BA-BCS 2021: An Initial “Trial” for Integrating Basic Science and Medical Progress on Breast Cancer in a Latin-American Country J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-10-12 Kordon, Edith, Lanari, Claudia, Mando, Pablo, Novaro, Virginia, Rossi, Mario, Simian, Marina
The first Buenos Aires Breast Cancer Symposium (BA-BCS) was held in a virtual format, between the 17th and the 21st of May 2021. The main goal of the meeting was to facilitate the interaction among physicians and basic researchers from South America and with peers from the rest of the world. To embrace their different interests and concerns, the congress included not only talks on basic, translational
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In Utero Exposure to trans-10, cis-12 Conjugated Linoleic Acid Modifies Postnatal Development of the Mammary Gland and its Hormone Responsiveness J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-10-06 Berryhill, Grace E., Gloviczki, Julia M., Trott, Josephine F., Kraft, Jana, Lock, Adam L., Hovey, Russell C.
We previously showed that dietary trans-10, cis-12 conjugated linoleic acid (10,12 CLA) stimulates estrogen-independent mammary growth in young ovariectomized mice. Here we investigated the effects of in utero or postnatal exposure to cis-9, trans-11 (9,11 CLA) and 10,12 CLA on postnatal development of the mammary gland and its responsiveness to ovarian steroids. In the first experiment we fed dams
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Estetrol and Mammary Gland: Friends or Foes? J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-08-31 Gallez, Anne, Dias Da Silva, Isabelle, Wuidar, Vincent, Foidart, Jean-Michel, Péqueux, Christel
Estrogens have pleiotropic effects on many reproductive and non-reproductive tissues and organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen receptor α functions as the principal mediator of estrogenic action in most of these tissues. Estetrol (E4) is a native fetal estrogen with selective tissue actions that is currently approved for use as the estrogen component
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Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle? J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-08-27 Reye, Gina, Huang, Xuan, Haupt, Larisa M., Murphy, Ryan J., Northey, Jason J., Thompson, Erik W., Momot, Konstantin I., Hugo, Honor J.
Regions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned collagen fibrils to control tissue stiffness and hence the response to mechanical forces. Literature is accumulating to support the notion that mechanical stiffness may drive PG synthesis in the breast contributing to MD. We review emerging patterns in MD and
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Twelfth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-08-26 Charifou, Elsa, Traustadottir, Gunnhildur Asta, Bentires-Alj, Mohamed, Howard, Beatrice, Van Keymeulen, Alexandra
The twelfth annual workshop of the European Network for Breast Development and Cancer focused on methods in mammary gland biology and breast cancer, was scheduled to take place on March 26–28, 2020, in Weggis, Switzerland. Due to the COVID-19 pandemic, the meeting was rescheduled twice and eventually happened as a virtual meeting on April 22 and 23, 2021. The main topics of the meeting were branching
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Mammary Development and Breast Cancer: a Notch Perspective J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-08-10 Chen, Weizhen, Wei, Wei, Yu, Liya, Ye, Zi, Huang, Fujing, Zhang, Liyan, Hu, Shiqi, Cai, Cheguo
Mammary gland development primarily occurs postnatally, and this unique process is complex and regulated by systemic hormones and local growth factors. The mammary gland is also a highly dynamic organ that undergoes profound changes at puberty and during the reproductive cycle. These changes are driven by mammary stem cells (MaSCs). Breast cancer is one of the most common causes of cancer-related death
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Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression J. Mammary Gland Biol. Neoplasia (IF 2.5) Pub Date : 2021-08-02 Zirbes, Arrianna, Joseph, Jesuchristopher, Lopez, Jennifer C., Sayaman, Rosalyn W., Basam, Mudaser, Seewaldt, Victoria L., LaBarge, Mark A.
A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell interactions are important during mammary gland development and the immune system plays an important role in BC progression. The composition of human immune cell populations is known