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Surface modification of artificial implants by hybrid nanolayers - antimicrobial surface finishing and strength tests. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-10-25 Jiří Škach,Irena Šlamborová,Hana Jelínek Šourková,Petr Exnar,Robert Gürlich
INTRODUCTION The aim of this work is the evaluation of surface modification in surgery of normally used hernia implants and thus improving their antimicrobial properties. The modification consisted of applying hybrid nanolayers with immobilized antiseptic substances (metal cations of Ag, Cu and Zn) by sol-gel method which ensures prolonged effect of these substances and thus enables a greater resistance
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Colonic Anastomotic Leak Model in Swine. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-10-13 Nour Helwa,Manaswi Sharma,Manasvi Sai Vanama,Youssef Helwa,Abdallah El-Falou
INTRODUCTION Anastomotic leaks are serious postoperative complications. Current experimental studies designed to investigate leaks are based on acute intraoperative dehiscence of the anastomosis. Clinically, however, AL usually happens later in the post-operative course. Presented here is a clinically relevant colonic anastomotic leak model in swine. METHODS 17 Yorkshire pigs were divided into 2 groups:
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Management and Outcomes of Major Pelvic Hemorrhage in Complex Abdomino-Pelvic Surgery. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-10-10 Erman Aytac,Selman Sökmen,Ersin Öztürk,Ahmet Rencüzoğulları,Uğur Sungurtekin,Cihangir Akyol,Sezai Demirbaş,Sezai Leventoğlu,Feza Karakayalı,Mustafa Ali Korkut,Mustafa Öncel,Barış Gülcü,Aras Emre Canda,İsmail Cem Eray,Utku Özgen,Şiyar Ersöz,Tahir Özer,İsmail Hakkı Özerhan,Osman Bozbıyık,Mustafa Haksal,Berke Mustafa Oral
INTRODUCTION Hemorrhage is a challenging complication of pelvic surgery. This study aimed to analyze the causes, management and factors associated with morbidity in patients experiencing major pelvic hemorrhage during complex abdomino-pelvic surgery. METHODS Patients who had major intraoperative pelvic hemorrhage during complex abdomino-pelvic surgery at 11 tertiary referral centers between 1997-2017
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Admission Hypocalcemia and the Need for Endoscopic and Clinical Interventions among Patients with Upper Gastrointestinal Bleeding. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-10-09 Alex Korytny,Fares Mazzawi,Erez Marcusohn,Amir Klein,Danny Epstein
INTRODUCTION Calcium is an essential co-factor in the coagulation cascade and hypocalcemia is associated with adverse outcomes in bleeding patients, including trauma patients, women with postpartum hemorrhage, and patients with intracranial hemorrhage. In this retrospective, single-center, cohort study, we aimed to determine whether admission ionized calcium (Ca++) is associated with higher rates of
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Systematic review and meta-analysis: Association between preoperative ustekinumab and surgical complications in Crohn's disease patients. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-08-18 Lingna Li,Ke Jiang,Dandi Lou,Mengting Zhang,Yetan Shi,Jingyi Shen,Xiaojun Fu
INTRODUCTION The impact of ustekinumab (UST) therapy on surgical complications in patients with Crohn's disease (CD) remains controversial. The aim of this meta-analysis is to explore the link between these two. METHODS Databases (PubMed, Web of Science, Cochrane, and Springer Link) were searched until April 2022. Studies of CD patients who received UST and no UST prior to surgery (including no biological
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Vagal nerve therapy in the management of obesity: a systematic review and meta-analysis. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-08-04 Michael G Fadel,Matyas Fehervari,Bibek Das,Payam Soleimani-Nouri,Hutan Ashrafian
INTRODUCTION The vagus nerve has an important role in satiety, metabolism and autonomic control in upper gastrointestinal function. However, the role and effects of vagal nerve therapy on weight loss remain controversial. This systematic review and meta-analysis assessed the effects of vagal nerve therapy on weight loss, body mass index (BMI) and obesity-related conditions. METHODS MEDLINE, EMBASE
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In Memoriam: Georg K. Uhlschmid (1937-2023). Eur. Surg. Res. (IF 1.6) Pub Date : 2023-06-26 Rudolf Steiner
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Breath Testing in the Surgical Setting: Applications, Challenges, and Future Perspectives. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-06-13 Caoimhe M Walsh,Michael G Fadel,Sara H Jamel,George B Hanna
BACKGROUND The potential for exhaled breath to be a valuable diagnostic tool is often overlooked as it can be difficult to imagine how a barely visible sample of breath could hold such a rich source of information about the state of our health. However, technological advances over the last 50 years have enabled us to detect volatile organic compounds (VOCs) present in exhaled breath, and this provides
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The Introduction of an MR-Conditional Prototype for Cardiopulmonary Bypass Support: Technical Aspects and System Requirements. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-05-25 Michael Hofmann,Martin Schmiady,Dominik Schulte,Samuel Sollberger,Thierry Carrel,Peter Hasenclever,Beat Werner,Mirko Meboldt,Michael Huebler,Marianne Schmid Daners
INTRODUCTION The use of cardiopulmonary bypass (CBP; also known as a heart-lung machine) in newborns with complex congenital heart defects may result in brain damage. Magnetic resonance imaging (MRI) assessments cannot be performed safely because the metal components used to construct CBP devices may elicit adverse effects on patients when they are placed in a magnetic field. Thus, this project aimed
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Expression Levels of MicroRNA-300/BCL2L11 in Papillary Thyroid Cancer and Their Clinical Diagnostic Values. Eur. Surg. Res. (IF 1.6) Pub Date : 2023-05-15 Yi Shen,Xiaoen Li,Rongli Xie,Yupan Chen,Xun Hu,Yaping Liu,He Ma
INTRODUCTION This research aims to explore the expression levels of microRNA (miRNA)-300/BCL-2-like protein 11 (BCL2L11) and their values in the clinical diagnosis of papillary thyroid cancer (PTC). METHODS Pathological tissues that were surgically removed for thyroid disease were selected. miR-300 and BCL2L11 expression levels in the samples were measured. Receiver operating characteristic (ROC) curves
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140th Congress of the German Society of Surgery (DGCH) Eur. Surg. Res. (IF 1.6) Pub Date : 2023-04-17
N/A Eur Surg Res 2023;64:1–96
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Clinical validation of comprehensive complication index in pancreaticoduodenectomy Eur. Surg. Res. (IF 1.6) Pub Date : 2023-04-17 Zhenghua Cai, Yifei Yang, Yuqing Han, Xu Fu, Liang Mao, Yudong Qiu
Purpose Although the Clavien-Dindo classification (CDC) is the most widely utilized method for quantifying surgical complications, it fails to properly capture all events. To address this, the comprehensive complication index (CCI) was introduced. The purpose of this study was to compare the CCI and CDC as predictors of postoperative length of stay (PLOS) and total hospitalization costs in patients
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Author Index Vol. 64, No. 1, 2023 Eur. Surg. Res. (IF 1.6) Pub Date : 2023-03-23
Eur Surg Res 2023;64:139
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Subject Index Vol. 64, No. 1, 2023 Eur. Surg. Res. (IF 1.6) Pub Date : 2023-03-23
Eur Surg Res 2023;64:140
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Effects of preoperative oral carbohydrate loading on Neutrophil/Lymphocyte Ratio and postoperative complications following colorectal cancer surgery: a randomized controlled study Eur. Surg. Res. (IF 1.6) Pub Date : 2023-03-20 Nermina Rizvanović, Višnja Nesek Adam, Merlina Kalajdžija, Senada Čaušević, Senad Dervišević, Jasmina Smajić
Introductionː Preoperative carbohydrate oral (CHO) drinks attenuate the surgical stress response; however, the effects of CHO supplementation on the neutrophil-to-lymphocyte ratio (NLR) as an inflammatory and immunology-based predictor remain unclear. This study evaluated the effects of preoperative CHO loading on NLR values and complications following open colorectal surgery compared with a conventional
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Time-related Evidence of Intestinal Oxidative Stress in Obstructive Jaundice-Induced Rats Eur. Surg. Res. (IF 1.6) Pub Date : 2023-03-15 Apostolos Angelis, Ioannis D. Kostakis, Konstantinos Lilimpakis, Electra Kalaitzopoulou, Polyxeni Papadea, Marianna Skipitari, Christos D. Georgiou, Costas Vagianos
Introduction: Obstructive jaundice is known to affect intestinal permeability and facilitate bacterial translocation through related mechanisms. This study was conducted to evaluate the alterations concerning blood biochemistry and levels of several markers of oxidative stress (OS) in blood and intestinal mucosa caused by obstructive jaundice and how these fluctuate over time, in order to further explore
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Rapamycin does not act as a dietary restriction mimetic in the protection against ischemia reperfusion injury Eur. Surg. Res. (IF 1.6) Pub Date : 2023-03-06 Eline van den Akker, Frank J.M.F. Dor, Jan N.M. IJzermans, Ron W.F. de Bruin
Introduction Short-term fasting protects against renal ischemia reperfusion injury (IRI). mTOR signaling is downregulated and may be involved in its protective effect. Rapamycin is considered a possible mimetic as it inhibits the mTOR-pathway. This study examines the effect of rapamycin on renal IRI. Methods Mice were divided in four groups : Ad libitum(AL), Fasted (F), AL treated with rapamycin (AL+R)
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Analysis on Efficacy of Hepatic Artery Infusion Chemotherapy with or without Lenvatinib for Unresectable Hepatocellular Carcinoma Eur. Surg. Res. (IF 1.6) Pub Date : 2023-02-22 Wei Yuan, Wenchao Yue, Huabing Wen, Xueqin Wang, Qi Wang
Background: For patients with advanced hepatocellular carcinoma (HCC), hepatic artery infusion chemotherapy (HAIC) is a common and mature treatment, but the safety and efficacy of HAIC combined with lenvatinib for advanced HCC patient treatment remains unclear. Therefore, this study compared the safety and efficacy of HAIC with or without lenvatinib in unresectable HCC patients. Methods: We retrospectively
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Animal Welfare: Severity Assessment in Experimental Research Eur. Surg. Res. (IF 1.6) Pub Date : 2023-02-08 André Bleich, Brigitte Vollmar, René H. Tolba
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Predictive value of body composition parameters for postoperative complications in patients received pancreaticoduodenectomy Eur. Surg. Res. (IF 1.6) Pub Date : 2023-02-08 Zhenghua Cai, Yifei Yang, Xu Fu, Liang Mao, Yudong Qiu
Introduction Sarcopenia and visceral obesity have been identified as risk factors for postoperative complications following hepatobiliary and colon surgery. However, the correlation between body composition parameters and morbidity following pancreatectomy remains unclear. This study aimed to assess the predictive value of body composition parameters measured from preoperative CT images for postoperative
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Acknowledgement to Reviewers Eur. Surg. Res. (IF 1.6) Pub Date : 2023-01-16
Eur Surg Res 2022;63:305–306
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How surgical research gave birth to a new clinical surgical field: A viewpoint from the Dallas Uterus Transplant Study Eur. Surg. Res. (IF 1.6) Pub Date : 2023-01-09 Liza Johannesson, Giuliano Testa, Briget da Graca, Anji Wall
Background: Uterus transplantation (UTx) has come of age in the 21st Century, building on the 20th Century developments in vascular anastomosis and effective immunosuppressive protocols enabling solid organ transplantation to become the life extending and life improving treatment option we know today. However, UTx has the goal of enabling reproduction, meaning that research focused on establishment
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Residents can do it! A hands-on training program in laparoscopic liver surgery for general surgery residents Eur. Surg. Res. (IF 1.6) Pub Date : 2023-01-02 Calin Popa, Nasser Abdul Halim, Cosmin Pestean, Ciprian Ober, Radu Elisei, Tareg Al Momani, Diana Schlanger, Florin Graur, Florin Zaharie, Nadim Al Hajjar
Introduction: Laparoscopic liver resections (LLR) constitute an area of surgery that has been kept away from residents in their hands-on training. The aim of our study is to assess the feasibility and the value of a didactic “step-by-step” program for LLR performed by residents using the swine training model Methods: From May 2018 to November 2019, three hands-on workshops were held. The protocol involved
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A modified transversal two-suture microsurgical intussusception vasoepididymostomy for the treatment of epididymal obstructive azoospermia Eur. Surg. Res. (IF 1.6) Pub Date : 2022-12-27 Zengqin Liu, Zheng Ding, Hongtao Jiang, Qian Yuan, Kefeng Xiao, Bin Wang
Introduction: We have developed a modified vasoepididymostomy procedure, namely "fenestrated" transversal two-suture microsurgical intussusception vasoepididymostomy. This study aimed to investigate the therapeutic efficacy and outcome of this fenestrated vasoepididymostomy for epididymal obstructive azoospermia. Methods: Microsurgical two-suture transversal intussusception vasoepididymostomy was performed
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Skin wound healing: of players, patterns and processes Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-23 Heiko Sorg, Christian G.G. Sorg
Wound healing of the skin is a very complex biological activity. For a better understanding, an attempt is made to describe and subdivide the different players (cell types and signaling molecules), patterns (different regeneration or repair mechanisms) and processes (division of the overall process into categories, phases and steps). However, this is always based on different points of view. On the
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Indocyanine green is a safe and effective alternative to radioisotope in breast cancer sentinel lymph node biopsy regardless of patient body mass index Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-21 Samantha Ng, Vassilis Pitsinis, Emad H. Elseedawy, Douglas Brown, Alessio Vinci, Benjamin A. Jones, E. Jane Macaskill
Introduction: A recent meta-analysis [1] has confirmed high sensitivity of indocyanine green (ICG) fluorescence mapping for sentinel node detection in early breast cancer. Concerns have previously been raised regarding the efficacy in patients with high body mass index (BMI). Materials and Methods: All consecutive patients undergoing sentinel lymph node biopsies (SLNB) for early breast cancer in NHS
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Regulation of FOXO3 on neuronal ferroptosis after intracerebral hemorrhage via modulating NOX4 transcription Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-15 Zhongzong Qin, Gang Zhu, Honghai Luo, Yifan Deng
Introduction: Intracerebral hemorrhage (ICH) is known to trigger neuronal ferroptosis while forkhead box O3 (FOXO3) is implicated in ICH. This study aimed to determine the specific effect of FOXO3 on neuronal ferroptosis after ICH. Methods: The ICH mouse model was established through the injection of bacterial collagenase type IV and the cell model was established in Hemin-induced HT-22 cells. Subsequently
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Stepwise approach for acquisition of microsurgical skills through rat orthotopic liver transplantation experiments Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-15
Although rat liver transplantation (LT) is useful in training surgeons to perform microsurgery, mastering these surgical techniques remains difficult. Systematized training protocols are needed that enable learning of the proper skills in a short period of time. The present study describes an efficient five-step rat LT training protocol for surgeons designed to be mastered within 3 months through continuous
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Preoperative predictive nomogram based on alanine aminotransferase, prothrombin time activity, and remnant liver proportion (APART score) to predict post-hepatectomy liver failure after major hepatectomy Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-14 Hiromitsu Maehira, Hiroya Iida, Haruki Mori, Nobuhito Nitta, Takeru Maekawa, Katsushi Takebayashi, Sachiko Kaida, Toru Miyake, Masaji Tani
Introduction: Post-hepatectomy liver failure (PHLF) is a serious complication associated with major hepatectomies. An accurate prediction of PHLF is necessary to determine the feasibility of major hepatectomy. This study aimed to assess the association between PHLF and preoperative laboratory and computed tomography (CT) findings. Methods: Medical records of 65 patients who underwent major hepatectomy
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Introduction of a new ex vivo porcine coronary artery model: Evaluation of the direct vascular injury after stent implantation with and without dogbone effect Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-14 Lisa Obermaier, Karla Lehle, Stefanie Schmid, Christof Schmid, Thomas Schratzenstaller
Introduction: Neointimal hyperplasia after percutaneous coronary intervention remains a major determinant of in-stent restenosis (ISR). The extent of mechanical vessel injury correlates with ISR. A new ex vivo porcine stent model was introduced and evaluated comparing different stent designs. Methods: Coronary arteries were prepared from pig hearts from the slaughterhouse and used for ex vivo implantations
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Erratum Eur. Surg. Res. (IF 1.6) Pub Date : 2022-11-01 Frank J.M.F. Dor, B. Vollmar, Oliver Kempski, Brigitte Vollmar, Frank J.M.F. Dor, Mihaly Boros, Markus Wolfgang Büchler, Henrik Thorlacius, Michael D. Menger, Wim P. Ceelen, K. Messmer, Niccolo Daddi, Helge E. Myrvold, Bo Risberg, Miguel Cainzos Fernandez, Michal Heger, Ulrich T. Hopt, Lorenzo Dominioni, D.J. Gouma, Jörg C. Kalff, Thomas Hubert, R.Y. Calne, R. Margreiter, Luca Ansaloni, Stefan Post
Eur Surg Res
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Does Sex Matter in Liver Surgery? Comparison of Severity Assessments between Female and Male Rats after Partial Hepatectomy - A Pilot Study Eur. Surg. Res. (IF 1.6) Pub Date : 2022-10-03 Anna Maria Kümmecke, Leonie Zieglowski, Lisa Ernst, Rupert Palme, René H. Tolba
Introduction: Current animal-based biomedical research, including studies on liver function and disease, is conducted almost exclusively on male animals to mitigate confounding effects of the estrous cycle. However, liver diseases afflict both men and women, so translational research findings should also be applicable to female patients. This pilot study investigated sex differences in objective and
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Stem cell therapies for gastrointestinal anastomotic healing: a systematic review and meta-analysis on results from animal studies Eur. Surg. Res. (IF 1.6) Pub Date : 2022-09-06 Apostolos Gaitanidis, Leonidas Kandilogiannakis, Eirini Filidou, Alexandra Tsaroucha, George Kolios, Michail Pitiakoudis
Background: Despite considerable progress in surgical techniques, anastomotic leak (AL) is a common complication after gastrointestinal surgery. Stem cells are a promising therapy to improve healing and have been used in gastrointestinal anastomoses. In this study, we perform a systematic review and meta-analysis to evaluate the efficacy of stem cell therapies in preventing ALs among animal studies
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DNA damage repair genes alterations in genito-urinary malignancies Eur. Surg. Res. (IF 1.6) Pub Date : 2022-08-09 Charles Dariane, Marc-Olivier Timsit
Background High-fidelity repair of DNA damage repair (DDR) [either single-strand- (SSBs) or double-strand breaks (DSBs)] is necessary for maintaining genomic integrity and cell survival. DDR alterations are commonly found in genito-urinary malignancies involving either DSBs repair by the homologous recombination repair (HRR) system (BRCA1/2 pathway) or the SSBs repair through the Poly-ADP-ribose polymerase
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A novel combination of keratinocyte and autologous microskin grafting to repair full thickness skin loss Eur. Surg. Res. (IF 1.6) Pub Date : 2022-08-04 Kai Yin, Dawei Li, Chuanan Shen, Yuru Shang, Longzhu Li, Dongxu Zhao, Wenfeng Cheng
The high mortality of patients with extensive deep burns is mainly attributed to the extensive burn wound and scarce autologous skin left for wound repair. The purpose of this study is to explore how to effectively use the limited remaining autologous skin to repair the extensive deep wound. Human keratinocytes harvested from the foreskin were cultured and transfected with epidermal growth factors
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MUCOSAL RECOVERY AFTER INTESTINAL TRANSPLANTATION IN THE RAT: A SEQUENTIAL HISTOLOGICAL AND MOLECULAR ASSESSMENT Eur. Surg. Res. (IF 1.6) Pub Date : 2022-08-04 Jasmine Bagge, Arvind Manikantan Padma, Anna Casselbrant, Mats Hellström, Mihai Oltean
Introduction Intestinal cold ischemia and subsequent reperfusion during transplantation result in various degrees of mucosal injury ranging from mild edema to extensive mucosal loss. Mucosal barrier impairment favours bacterial translocation and fluid loss and raises nutritional challenges. The injured intestine also releases proinflammatory mediators and upregulates various epitopes towards an inflammatory
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Post-operative severity assessment in sheep Eur. Surg. Res. (IF 1.6) Pub Date : 2022-07-15 Eva Zentrich, Laura Wassermann, Birgitta Struve, Kristin Selke, Manuela Buettner, Lydia Maria Keubler, Janin Reifenrath, Nina Angrisani, Merle Kempfert, Annika Krause, Olaf Bellmann, Marcin Kopaczka, Dorit Merhof, Marion Bankstahl, André Bleich, Christine Häger
Introduction: Sheep are frequently used in translational surgical orthopedic studies. Naturally, a good pain management is mandatory for animal welfare, although it is also important with regard to data quality. However, methods for adequate severity assessment, especially considering pain, are rather rare regarding large animal models. Therefore, in the present study, accompanying a surgical pilot
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Interferon regulatory factor 4 (IRF4) promotes lipopolysaccharide-induced colonic mucosal epithelial cell proliferation by regulating macrophage polarization Eur. Surg. Res. (IF 1.6) Pub Date : 2022-07-01 Lin Hu, Song Li, Honglang Li, Bin Lai, Huabin Wen
Introduction: Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of colon and rectum. Interferon regulatory factor 4 (IRF4) mediates macrophage anti-inflammatory phenotype (M2). This study aimed to investigate the mechanism of IRF4 in lipopolysaccharide (LPS)-induced colonic mucosal epithelial cell proliferation via the regulation of macrophage polarization
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THE LONG AND WINDING ROAD TO CLINICAL XENOTRANSPLANTATION – A PERSONAL JOURNEY Eur. Surg. Res. (IF 1.6) Pub Date : 2022-06-28 David K.C. Cooper
The recent clinical pig heart transplant carried out at the University of Maryland in Baltimore is hopefully the first of many xenotransplants that will resolve the problem of the lack of availability of organs from deceased human donors. I offer my personal recollections of how xenotransplantation research has progressed since the mid-1980s, when the pig-to-nonhuman primate (NHP) organ transplant
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The open field test as a tool for behaviour analysis in pigs – recommendations for set-up standardisation. A systematic review. Eur. Surg. Res. (IF 1.6) Pub Date : 2022-06-22 Mareike Schulz, Leonie Zieglowski, Marcin Kopaczka, René H. Tolba
Introduction: The open field (OFT) test is a common tool to assess anxiety and behavioural changes in rodents. It has been adapted to pigs with no systematic investigation of how environmental changes may alter the performance of pigs. Currently, the number of published studies including the OFT in domestic pig models is increasing without standardisation Methods: Our review aimed to investigate the
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Effect of gastrojejunostomy position on the postoperative amount of oral intake in pancreaticoduodenectomy Eur. Surg. Res. (IF 1.6) Pub Date : 2022-06-16 Hiroya Iida, Hiromitsu Maehira, Takeru Maekawa, Haruki Mori, Nobuhito Nitta, Katsushi Takebayashi, Masatsugu Kojima, Mika Kurihara, Shigeki Bamba, Masaya Sasaki, Masaji Tani
Introduction We investigated the effect of the gastrojejunostomy position on the postoperative oral intake in patients who have undergone PD. Methods We investigated 119 patients who underwent PD between June 2013 to December 2019 and examined the effect of the horizontal and vertical distance rates of the gastrojejunostomy position on the postoperative oral intake. The patients were categorized as
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Preoperative physical activity level measurement by accelerometer for predicting post-hepatectomy complications: a prospective observational study Eur. Surg. Res. (IF 1.6) Pub Date : 2022-05-30 Hiroya Iida, Hiromitsu Maehira, Haruki Mori, Katsushi Takebayashi, Masatsugu Kojima, Sachiko Kaida, Tomoyuki Ueki, Toru Miyake, Masaji Tani
Introduction Recently, accelerometers have received much attention around the world. This study examined whether preoperative physical activity level measured by an accelerometer can be a useful predictor of post-hepatectomy complications. Methods Between December 2016 and December 2020, the physical activity levels of 185 patients were measured using an accelerometer 3 days before hepatectomy and
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A Rat Model of Esophagogastric Anastomotic Stricture Eur. Surg. Res. (IF 1.6) Pub Date : 2022-05-23 Nan Li, Xiang Fei, Chunguang Li, Tiejun Zhao, Hai Jin, Hezhong Chen
Esophagogastric anastomosis stricture is one of the most common postoperative complications after esophagectomy; yet, its pathogenesis is still not fully understood, and the treatment and prevention of anastomotic stricture are limited due to the lack of a proper animal model. The insufficient blood supply in the gastric tube is considered a risk factor for postoperative anastomotic strictures. In
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Erratum Eur. Surg. Res. (IF 1.6) Pub Date : 2022-05-04 Frank J.M.F. Dor, B. Vollmar, Oliver Kempski, Brigitte Vollmar, Frank J.M.F. Dor, Mihaly Boros, Markus Wolfgang Büchler, Henrik Thorlacius, Michael D. Menger, Wim P. Ceelen, K. Messmer, Niccolo Daddi, Helge E. Myrvold, Bo Risberg, Miguel Cainzos Fernandez, Michal Heger, Ulrich T. Hopt, Lorenzo Dominioni, D.J. Gouma, Jörg C. Kalff, Thomas Hubert, R.Y. Calne, R. Margreiter, Luca Ansaloni, Stefan Post
Eur Surg Res
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Welfare assessment on healthy and tumor-bearing mice after repeated ultrasound imaging Eur. Surg. Res. (IF 1.6) Pub Date : 2022-04-08 Renée Michèle Girbig, Jasmin Baier, Rupert Palme, René Tolba, Anne Rix, Fabian Kiessling
Introduction: Ultrasound (US) imaging enables tissue visualization in high spatial resolution with short examination times. Thus, it is often applied in preclinical research. Diagnostic US, including contrast-enhanced ultrasound (CEUS), are considered to be well tolerated by laboratory animals although no systematic study has been performed to confirm this claim. Therefore, the aim of this study was
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Severity Assessment in Rats Undergoing Subarachnoid Hemorrhage Induction by Endovascular Perforation or Corresponding Sham Surgery. Eur. Surg. Res. (IF 1.6) Pub Date : 2022-04-06 Annika Bach-Hagemann,Ekaterina Harder,Laura Warner,Catharina Conzen-Dilger,Tobias Philip Schmidt,Sarah Pinkernell,Rupert Palme,Ute Lindauer
INTRODUCTION Animal models for preclinical research of subarachnoid hemorrhage (SAH) are widely used as much of the pathophysiology remains unknown. However, the burden of these models inflicted on the animals is not well characterized. The European directive requires severity assessment-based allocation to categories. Up to now, the classification into predefined categories is rather subjective and
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Soluble Urokinase Receptor Levels Are Not Affected by the Systemic Inflammatory Response to Anesthesia and Operative Trauma. Eur. Surg. Res. (IF 1.6) Pub Date : 2022-04-06 Eleni Laou,Nikolaos Papagiannakis,Aikaterini Tsiaka,Stamatina Tsapournioti,Konstantinos Chatzikallinikidis,Georgios Mantzaflaras,Ioannis Karadontas,Jesper Eugen-Olsen,Athanasios Chalkias
INTRODUCTION Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker of the level of chronic systemic inflammation and the general condition of the patient. We aimed to investigate the impact of general anesthesia and major surgery on perioperative suPAR and C-reactive protein (CRP) levels. METHODS This study included patients undergoing elective major noncardiac surgery with
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139th Congress of the German Society of Surgery (DGCH) Eur. Surg. Res. (IF 1.6) Pub Date : 2022-04-01
Eur Surg Res 2022;63:I–II
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139th Congress of the German Society of Surgery (DGCH) Eur. Surg. Res. (IF 1.6) Pub Date : 2022-03-31
Eur Surg Res
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Blocking of CX3CL1 attenuates platelet and leukocyte recruitment in murine hepatic I/R Eur. Surg. Res. (IF 1.6) Pub Date : 2022-03-11 Dominik Funken, Alexandra Brüggemann, Konstantin Mende, Maximilian Lerchenberger, Markus Rentsch, Andrej Khandoga
Background. The chemokine fractalkine (CX3CL1) is critically involved in the pathophysiology of different inflammatory diseases and myocardial ischemia-reperfusion (I/R). This study aims to analyze the role of fractalkine in the activation of platelets and leukocytes during hepatic I/R. Methods. Under inhalation anesthesia, C57BL6 mice were subjected to warm hepatic I/R (90min/240min). The animals
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Effects of Oral Pirfenidone on Colon Anastomosis Healing and Adhesion Formation in Rats Eur. Surg. Res. (IF 1.6) Pub Date : 2022-02-23 Shadya Betancourt-Vicencio, Manuel Rodrigo Prieto-Aldape, Andrea Socorro Alvarez-Villaseñor, Clotilde Fuentes-Orozco, Ana Olivia Cortes-Flores, Guadalupe Castillo-Cardiel, José Antonio Sánchez-Martínez, Emilio Alberto Reyes-Elizalde, Paola Guadalupe González-Hernández, José Gerardo Zamora-Inzunza, Victoria Amaranta Romero-Arredondo, José Francisco Barbosa-Camacho, Irma Valeria Brancaccio-Pérez, Bertha
Introduction: Many experimental studies have examined multiple drugs or treatments to improve the healing of intestinal anastomoses. Synthetic prostacyclin analogues, immunosuppressants, erythropoietin, growth hormone, insulin-like growth factor type 1, synthetic metalloproteinases inhibitors, and hyperbaric oxygen therapy have produced promising results in low-risk models of anastomosis dehiscence
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Treatment with the 5-LOX antagonist Zileuton protects mice from postoperative ileus Eur. Surg. Res. (IF 1.6) Pub Date : 2022-02-18 Jana Enderes, Shilpashree Mallesh, Kathy Stein, Melissa Wagner, Mariola Lysson, Bianca Schneiker, Joerg C. Kalff, Sven Wehner
Introduction Previous work of our group showed that lipoxygenase (LOX) pathways become activated upon surgical manipulation of the bowel wall and revealed a beneficial immune modulating role of the LOX-derived anti-inflammatory mediator protectin DX in POI. While we found a particular role of 12/15-LOX in the anti-inflammatory LOX action during postoperative ileus (POI), the role of 5-LOX, which produces
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Frailty predicts postoperative complications following pancreaticoduodenectomy Eur. Surg. Res. (IF 1.6) Pub Date : 2022-02-16 Vivian Li, Amen Awan, Pablo E. Serrano
Introduction: Frailty is a clinically recognizable state of decreased reserve and function across physiologic systems, characterized by an inability to cope with acute stressors. A validated modified frailty index (mFI) was used to evaluate the impact of frailty on postoperative complications following pancreaticoduodenectomy. Methods: Data from consecutive patients undergoing pancreaticoduodenectomy
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European Surgical Research: the future is bright! Eur. Surg. Res. (IF 1.6) Pub Date : 2022-02-16 Frank J.M.F. Dor, Brigitte Vollmar
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Left Ventricular Wall Reconstruction with Autologous Vascularized Gastric Graft in a Porcine Pilot Model Eur. Surg. Res. (IF 1.6) Pub Date : 2022-02-08 Tobias Schilling, Tanja Meyer, Gudrun Brandes, Dagmar Hartung, Igor Tudorache, Ingo Nolte, Frank Wacker, Andres Hilfiker, Klaus Hoeffler, Axel Haverich, Serghei Cebotari
Introduction: Surgical replacement of dysfunctional cardiac muscle with regenerative tissue is an important option to combat heart failure. But current available myocardial prostheses like a Dacron or a pericardium patch neither have a regenerative capacity nor do they actively contribute to the heart`s pump function. This study aimed to show the feasibility of utilizing a vascularized stomach patch
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Long-term outcomes of left versus right laparoscopic living donor nephrectomy with multiple renal arteries Eur. Surg. Res. (IF 1.6) Pub Date : 2022-01-31 Abdulhak Hamit Karayagiz, Sevval Besli, Gulay Yilmaz, Ebru Ozdemir, Ulkem Cakir, Ibrahim Berber
Objectives: The objective of this study is to compare the long-term graft outcomes of left versus right donor nephrectomy with multiple renal arteries, and therefore creating a reference for the expansion of the potential living kidney donor pool. Methods: Laparoscopic live donor nephrectomy cases between May 2010 and October 2020 were included in this retrospective cross-sectional study. The data
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Toward evidence-based severity assessment in mouse models with repeated seizures: (II.) Impact of surgery and intrahippocampal kainate Eur. Surg. Res. (IF 1.6) Pub Date : 2022-01-24 Verena Buchecker, Ines Koska, Claudia Pace, Steven R. Talbot, Rupert Palme, Andre Bleich, Heidrun Potschka
Introduction: Chronic epilepsy models require neurosurgical procedures including depth electrode implants. The intrahippocampal kainate model is a frequently used chronic paradigm, which is based on chemoconvulsant administration and status epilepticus induction during the surgical procedure. This experimental approach raises the question to what extent this approach affects post-surgical recovery
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Potentials of CCL21 and CBS as therapeutic approaches for breast cancer Eur. Surg. Res. (IF 1.6) Pub Date : 2022-01-13 Jing Peng, Danhua Zhang
Objective: The present research set out to ascertain the roles of CCL21 and CBS in breast cancer (BC) cell biological behaviors and the relationship of CCL21 and CBS expression with the clinicopathological features of patients with BC. Methods: Immunohistochemistry of CCL21 or CBS was performed in 18 intraductal cancer tissues, 124 invasive BC tissues, 50 paraneoplastic tissues, 50 lobular hyperplasia