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From a Spark to a Flame: The Evolution of Diabetic Foot Disease in the Last Two Decades Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-03-12 Marco Meloni, Alberto Piaggesi, Luigi Uccioli
Despite many improvements have been achieved, diabetic foot disease (DFD) remains a clinical, social, and economic burden. In the last years, DFD showed an evolution of its characteristics with an increase of the ischaemic/neuro-ischaemic foot in comparison to the pure neuropathic foot. Simultaneously, there was and increased incidence of concomitant cardiovascular co-morbidities, which influences
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The Influence of Honey and Hydrogel Products Therapy on Healing Time in Diabetic Foot Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-03-01 Wael Mahmoud Searan, Mohammed A. Abdalqader, Husmi Ahmed Al-Goshae, Hamdan Mohammed Nor, Hamad Saleh Al-Shubrumi, Hani Badahdah
BackgroundDiabetic foot ulcer is a serious and common complication of diabetes that often leads to significant morbidity and even amputation if not properly treated. Current treatment options, such as wound dressing, have limitations in promoting efficient healing. There is a need for effective interventions that can expedite the healing process and enhance the time required for complete healing.MethodologyThis
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Development of Cyclic Pressure Offloading Insole for Diabetic Foot Ulcer Prevention Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-29 Veysel Erel, Aida Nasirian, Yixin Gu, Larry Lavery, Muthu B. J. Wijesundara
Introduction. The likelihood of developing a diabetic foot ulcer (DFU) during one's lifetime for individuals with diabetes mellitus is around 19% to 34%. Continuous and repetitive loading on soft tissues are the major causative factors for DFU. This paper introduces an air cell array insole designed for cyclically offloading pressure from plantar regions to reduce repetitive stress and loading on foot
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A Simple Guide to Randomized Controlled Trials Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-29 Aris Liakos, Eirini Pagkalidou, Thomas Karagiannis, Konstantinos Malandris, Ioannis Avgerinos, Eleni Gigi, Eleni Bekiari, Anna-Bettina Haidich, Apostolos Tsapas
Randomized controlled trials represent the cornerstone for the regulatory approval of drugs and evidence-based medicine and policy. Compared with observational studies random assignment of participants to each study arm guarantees an equal distribution of potential confounders thus achieving impartiality in the evaluation of between group differences and allowing for causal inferences to be drawn.
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Appropriateness of Artificial Intelligence Chatbots in Diabetic Foot Ulcer Management Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-29 Makoto Shiraishi, Haesu Lee, Koji Kanayama, Yuta Moriwaki, Mutsumi Okazaki
Type 2 diabetes is a significant global health concern. It often causes diabetic foot ulcers (DFUs), which affect millions of people and increase amputation and mortality rates. Despite existing guidelines, the complexity of DFU treatment makes clinical decisions challenging. Large language models such as chat generative pretrained transformer (ChatGPT), which are adept at natural language processing
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What is New on Diabetic Neuropathy? Insights from the 2023 ADA and EASD Conferences Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-28 Eleni Rebelos, Ioanna A. Anastasiou, Anastasios Tentolouris, Nikolaos Papanas, Edward Jude
Diabetic neuropathy is a common complication of diabetes; yet its pathophysiology is still incompletely understood and until today, there is no specific treatment against it. In the two 2023 large congresses on diabetes (American Diabetes Association, ADA, European Association for the Study of Diabetes, EASD), several high-level studies have been presented. They have attempted to delineate the pathophysiology
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The Relationship Between Health Literacy and Diabetes Self-Efficacy and Foot Self-Care in Type II Diabetics Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-28 Burcu Kaplan, Hatice Serap Koçak, Emine Kaplan Serin
This study was conducted to determine the effect of health literacy on diabetes self-efficacy and foot self-care in type II diabetics. This descriptive correlational study was conducted with 187 people. The research was conducted between 01 June 2021 and 31 December 2021 in a province located in the southeastern region of Turkey. Non-probability purposive sampling was used as the sampling method. An
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Prognostic Significance of NLR, LMR, PLR, and CRP-Albumin Ratio in Lower Extremity Cellulitis: A Hospitalization and Recurrence Analysis Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-28 Pınar Yürük Atasoy, Esra Gürbüz, Sevil Alkan
Cellulitis, an inflammatory disease of the skin and subcutaneous tissue caused by bacterial agents, frequently causes lower-extremity wounds. Many new biomarkers have been introduced to aid the diagnosis of inflammatory diseases. In this study, we aimed to evaluate the risk of recurrence of lower-extremity cellulitis wounds and the factors determining the need for hospitalization. Demographic characteristics
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Effectiveness of APG and Honey Gauze in Pressure Injury of Elderly: A Randomized Control Trial Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-26 Lulu Xu, Xinmeng Wang, Yongmei Wu, Zhen Zhang, Xiafei Li, Jie Zhang
This study was designed to evaluate the efficiency of the combination of autologous platelet-rich plasma gel (APG) and Manuka honey gauze in the treatment of Stages 3–4 pressure injury of older adults. Patients were divided into four groups: Manuka honey gauze and APG (M + A), Manuka honey gauze (M), APG (A), and a control group (C). Different treatments were given, then wound bed coverage with granulation
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Associations Between Systolic Pressure, Vascular Waveform, and Volume Flow with Debridement or Amputation Treatment Decisions in Diabetic Foot Ulcer Patients Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-23 Patrianef Darwis, Ahmad Syaifudin, Raden Suhartono, Akhmadu Muradi, Dedy Pratama, Dian Kusuma Dewi, Alif Hamzah
IntroductionDiabetic foot ulcer disease, affecting 6.3% of the global population, necessitates crucial decisions regarding debridement and amputation, with substantial cost, morbidity, and mortality implications. This study's primary goal is to determine effective vascular examination modalities, including systolic blood pressure, vascular waveforms, and blood volume flow to guide optimal treatments
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A Systematic Review and Classification of Factors Influencing Diabetic Foot Ulcer Treatment Adherence, in Accordance With the WHO Dimensions of Adherence to Long-Term Therapies Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-20 Gwyneth WY Ng, Keith F Gan, Huiling Liew, Lixia Ge, Gary Ang, Joseph Molina, Yan Sun, Prajwala S Prakash, Keerthi B Harish, Zhiwen Joseph Lo
PurposeEffective treatment of diabetic foot ulcers (DFUs) involves a multidisciplinary treatment plan to promote wound healing and prevent complications. Given the lack of consensus data on the factors affecting patient adherence, a systematic review was performed to identify and classify factors according to the WHO Dimensions of Adherence to Long-Term Therapies.MethodsSix hundred and forty-three
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Studying Microbial Ecology of Diabetic Foot Infections: Significance of PCR Analysis for Prudent Antimicrobial Stewardship Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-19 Deema Jaber, Nidal Younes, Enam Khalil, Abla Albsoul-Younes, Mohammed Zawiah, Amal G. Al-Bakri
This study presents a comprehensive investigation into the microbial ecology of diabetic foot infections (DFIs), using molecular-polymerase chain reaction (PCR) analysis to accurately identify the causative agents. One hundred DFI patients were recruited and classified using the Depth Extent Phase and Associated Etiology (DEPA) score according to their severity. Results revealed polymicrobial infections
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Updated Scenario on Negative Pressure Wound Therapy Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-08 Harish Bhardwaj, Renjil Joshi, Anshita Gupta
Negative pressure wound therapy (NPWT) is a widely used and effective treatment for managing complex wounds. This document discusses how NPWT can be used in wound care in an updated way. The updated scenario on NPWT provides a concise overview of the current state of NPWT and its implications in clinical practice. It highlights recent developments in NPWT, as well as the advancements in this field
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Oxygen Therapy to Enhance Wound Healing After Revascularization Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-05 Kusuma Chinaroonchai
Oxygen is one of the important factors for wound healing and infection control. The revascularization procedure is amended to correct the tissue hypoxia problem by increasing the blood flow to obtain an adequate amount of oxygen. Hypoxic wounds are still the issue in the cases of unsuccessful or incomplete revascularization. The issue needs to be clarified and confirmed by proper methods for management
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Effectiveness of Stem Cell Therapy for Diabetic Foot Ulcers: A Systematic Review and GRADE Compliant Bootstrapped Meta-Analysis of Randomized Clinical Trials Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-01 Shiv Kumar Mudgal, Subodh Kumar, Rakhi Gaur, Harminder Singh, Dibyajyoti Saikia, Saurabh Varshney, Pratima Gupta, Ashoo Grover, Seshadri Reddy Varikasuvu
Diabetic foot (DF) represents a severe complication of diabetes mellitus, imposing substantial psychological and economic burdens on affected individuals. This investigation sought to assess the therapeutic efficacy of stem cell interventions in the management of DF complications. A comprehensive systematic search across PubMed, Embase, CINAHL, Scopus, and the Cochrane library databases was conducted
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Botulinum Toxin to Improve the Prognosis of Skin Transplantation: A Short Narrative Review Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-02-01 Xiangyan Hu, Yang Liu, Fengying Yang, Weigang Hu, Xifeng Sun
Skin transplantation is a traditional and well-established method of repairing skin loss, especially deep second-degree postburn wounds. Complications often happen amid the healing process, including necrosis and skin contracture, which has raised widespread concern from patients and doctors. Since the first recorded medical application of botulinum toxin for strabismus, accumulating evidence has enclosed
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Efficacy and Safety of Platelet-Rich Plasma for Pressure Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2024-01-19 Zhonglin Hu, Haona Xv, Aiping Feng, Senmao Wang, Xuefeng Han
Pressure ulcers are common chronic wounds in clinical practice, severely affecting patients’ quality of life and causing substantial economic burdens. Platelet-rich plasma (PRP) has been explored for its potential in treating pressure ulcers. Herein, a study was carried out to evaluate the efficacy and safety of PRP in comparison to conventional treatments for pressure ulcers. A comprehensive search
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Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-11 Mohamed Elsharkawi, Baker Ghoneim, Miriam O’Sullivan, Aoife J. Lowery, Daniel Westby, Wael Tawfick, Stewart R Walsh
Few studies to date have investigated the role of adipose derived stem cells (ADSCs) in patients with diabetic foot ulcers (DFU). We aimed to conduct a systematic search of the literature to explor...
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The Impact of Implementing a Diabetic Limb-Preservation Program on Amputation Outcomes at an Academic Institution in a Majority-Minority State Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-09 Eric Lew, Nathaniel Perryman Collins, John Marek, Robert C Schenck, Dustin Richter, Regina Gallegos, Leslie Dunlap, Richard Murdock
Background. Diabetic foot osteomyelitis may precede major limb amputations and lengthy hospital admission. These complications impact patients’ morbidity and mortality. Healthcare institutions with...
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The Effect of Standard Compression Adjuvant with a Tailored Exercise Training Program on Health-Related Quality of Life Outcomes in Treating Adults with Venous Leg Ulcer: A Randomized Controlled Trial Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-08 Amaraporn Rerkasem, Sothida Nantakool, Kanokwan Kulprachakarn, Christine Rojawat, Sakaewan Ounjaijean, Sasinat Pongtam, Mujalin Prasannarong, Suwinai Saengyo, Thanadul Jakkaew, Kittipan Rerkasem
Exercise training adjuvant to standard compression is considered to improve calf muscle pump dysfunction in venous leg ulcer (VLU) and subsequent healing. The objectives of this trial were to asses...
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The Effect of Amnion Cell Culture Medium on Wound Healing: An Experimental Animal Study Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-07 Tayfun Bilgic
Background/objectiveFetal wound repair seems a relatively efficient process when compared to wound repair during adulthood, which may be explained by the effects of the fetal environment. This stud...
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Old Wine in new Bottles: Silver Sulfadiazine Nanotherapeutics for Burn Wound Management Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-07 Harshita Abul Barkat, Muhammad Abul Barkat, Raisuddin Ali, Hazrina Hadi, Abdul Razak Kasmuri
According to the World Health Organization (WHO), ∼180,000 casualties are recorded every year due to burns, majorly from low- and middle-income countries that require medical attention. For the las...
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A Simple Guide to Systematic Reviews and Meta-Analyses Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-05-01 Chrysanthi Mantsiou, Aris Liakos, Maria Mainou, Nikolaos Papanas, Apostolos Tsapas, Eleni Bekiari
Systematic reviews and meta-analyses lie on the top of the evidence hierarchy because they utilize explicit methods for literature search and retrieval of studies relevant to the review question as...
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Should Long-Term Survival in Elderly Patients Presenting with Diabetic Foot Complications Impact Treatment Decision Making? Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-04-20 Erwin Yii, Jonathan Tiong, Sam Farah, Husein Al-Talib, Jonathan Clarke, Ming Kon Yii
Patients presenting with diabetic foot ulceration (DFU) and associated complications often require revascularisation. Although current evidence advocates for an open bypass first strategy if patien...
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Diabetic Amputations in 2023 are Still More Frightening Than Death—Act Now Before it is Too Late Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-04-20 Cynthia Formosa, Nachiappan Chockalingam, Alfred Gatt, Nikolaos Papanas
Despite huge medical and technological advances to date for the diagnosis, monitoring, and management of diabetic foot complications, their prevalence is still alarmingly high. Patients’ quality of...
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Effectiveness of Off-Loading Devices in Patients With Active Diabetic Foot Ulcer: A Systematic Review Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-30 Susana Velasco-Rodríguez-Rabadán, Aroa Tardáguila-García, Irene Sanz-Corbalán, Marta García-Madrid, Mateo López-Moral, José Luis Lázaro-Martínez
A systematic review of the effectiveness of off-loading in the diabetic foot was done. Searches were conducted in October 2022 using the PubMed and Scielo databases. Randomized clinical trials or c...
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Onset of an Active Charcot Foot in a Person with Longstanding Type 1 Diabetes and Normal Vibration Perception Threshold—A Case Report Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-30 Nina L. Petrova, Rumaisa Banatwalla, Katharine F. Hunt, Raju Ahluwalia, David A. Elias, Maureen Bates, Prashanth R. J. Vas
Charcot neuro-osteoarthropathy (CNO), or Charcot foot, is a disabling complication of diabetes, which is poorly understood and frequently overlooked. We describe an atypical presentation of an acti...
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Mean Platelet Volume-to-Lymphocyte Ratio Is a Biomarker of 1-Year Mortality in Patients With Diabetic Foot Infections Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-27 Javier Aragón-Sánchez, Gerardo Víquez-Molina, María Eugenia López-Valverde, Cristina Aragón-Hernández, Javier Aragón-Hernández, José María Rojas-Bonilla
We aimed to evaluate the value of 2 peripheral blood cell ratios, the mean platelet volume-to-lymphocyte ratio (MPVLR) and the neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers of morta...
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Precision of Michigan Neuropathy Screening Instrument (MNSI) Tool for the Diagnosis of Diabetic Peripheral Neuropathy Among People with Type 2 Diabetes—A Study from South India Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-15 Vijay Viswanathan, Balkhiwala Ahmed Khan, Sukanya Nachimuthu, Satyavani Kumpatla
Diabetic peripheral neuropathy (DPN) is one of the risk factors for foot-related complications among people with type 2 diabetes mellitus (T2DM). Hence, we aimed to validate the Michigan Neuropathy...
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Fractional Epidermal Skin Grafts in Hard-to-Heal Wounds: Case Series Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-15 Agata Janowska, Cristian Fidanzi, Marco Romanelli, Michela Iannone, Teresa Oranges, Francesca Montaquila, Valentina Dini
Cellutome™ is a minimally invasive, automated system for harvesting fractional epidermal micrografts. This therapy is indicated for granulating, small size, poor exuding acute wounds. We enrolled 1...
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Diabetic Foot Osteomyelitis: Is it all the Same? Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-07 Gabriela Verónica Carro, Fermín Martinez de Jesus, Anahí Ricci
Diabetic foot osteomyelitis (OM) requires a longer duration of therapy, a greater need for surgery and implies a higher rate of recidivism, a higher amputation risk, and lower treatment success. Bu...
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Overexpression of miR-7-5p Promoted Fracture Healing Through Inhibiting LRP4 and Activating Wnt/β-Catenin Pathway Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-03-07 Changtie Li, Junlin Liu, Hong Chen
Background. The bone healing after fracture had a great impact on the patients’ life quality. However, how miR-7-5p participated in fracture healing has not been investigated. Methods. For in vitro...
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Mycetoma (Madura foot): A Case Report of a Rare Tropical Disease in Turkey Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-22 Elif Kuzucular, Abdulkadir Eren, Eray Isik, Ferhat Ozden
Mycetoma is a chronic discharging infection involving the skin, subcutaneous tissue, fascia, and bone, which is endemic in tropical and subtropical countries. We report a rare case of mycetoma loca...
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Effect of Partial Foot Amputation Level on Gait Independence in Patients With Chronic Lower Extremity Wounds: A Retrospective Analysis of a Japanese Multicenter Database Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-22 Yuma Sonoda, Noriaki Maeshige, Mikiko Uemura, Shinsuke Imaoka, Nobuhide Kawabe, Hisae Hayashi, Miki Fujii, Yoriko Tsuji, Masahide Furukawa, Masahiro Kohzuki, Hiroto Terashi
Partial foot amputation (PFA) is generally planned to minimize the amputation level; nonetheless, the effect of PFA levels on gait independence in amputees remains unclear. This study aimed to inve...
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The Bridging Effect of Artificial Dermis on Reconstruction of Skin Avulsion Injury Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-22 Yun-Nan Lin, Yu-Chi Wang, Su-Shin Lee, Meng-Chien Willie Hsieh, Sin-Daw Lin, Shu-Hung Huang, Tsai-Ming Lin, Yur-Ren Kuo
Skin avulsion wounds are expected to be swollen and tense after trauma, and skin perfusion can be compromised after primary closure, resulting in wound dehiscence and poor healing. The artificial d...
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Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-22 Bhavani Prasad Mahindrakar, Aakansha Giri Goswami, Farhanul Huda, Manisha Naithani, Somprakas Basu
AimTo monitor wound pH and surface temperature as predictors of wound healing in diabetic foot ulcers (DFU).MethodsProspective, observational, time-bound study of 18 months, enrolling patients aged...
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Tracking a Fatal Disease: Lower Limb Gas Gangrene's Mortality-Related Factors Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-21 Mohamed Farès Mahjoubi, Bochra Rezgui, Mohamed Maatouk, Nada Essid, Yasser Karoui, Hajer Kandara, Mounir Ben Moussa
IntroductionBecause of its rarity compared to dry and wet gangrene of the lower limb, the gaseous form has often been considered as the most severe form of gangrenous disease. We aimed to report cl...
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Comparing the Effects of Two Cryoprotectant Protocols, Dimethyl-Sulfoxide (DMSO) and Glycerol, on the Recovery Rate of Cultured Keratinocytes on Amniotic Membrane Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-16 Najmeh Mohammad-Pour, Vahid Moghimi, Hamid Reza Bidkhori, Madjid Momeni-Moghaddam, Hojjat Naderi-Meshkin
Background: Off-the-shelf supply of viable engineered tissue is critical for effective and fast treatment of life-threatening injuries such as deep burns. An expanded keratinocyte sheet on the huma...
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Letter to Editor Regarding “Methylene Blue Staining and Ultrasonic Debridement: A Superior Therapeutic Strategy for Pressure Ulcer Debridement” Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-12 Yu-Ren Duan, Xiao-Bing Wang, Bao-Lin Zhang
The treatment of pressure ulcer is of an extreme clinical and social concern. Effective and thorough debridement lays the foundation for favorable wound healing. Recently, a case report confirmed t...
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A Systematic Review of Cognitive Functioning and its Relationship to Outcomes Following Amputation Secondary to Vascular Etiology Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-09 Erinn Dawes, Lyndel L. Hewitt, Vida V. Bliokas, Val J. Wilson
Amputation is a major life event, impacting on all aspects of daily living, and has the goal of achieving maximal patient mobility and independence. The level of cognitive function of those patient...
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Reconstruction of Small-Sized Complex Defect on the Foot Dorsum Without Microsurgery: Intrinsic Adipofascial Flap Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-10 Seong Ju Choi, Young Ho Lee, Min Bom Kim, Kee Jeong Bae, Segi Kim, Yohan Lee
Dorsal foot defects are difficult to cover and often require major flap surgery by microsurgeons, even for defects of limited sizes. Intrinsic adipofascial flaps for small-sized complex defects are...
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The Course of Diabetic Foot Infection in Elderly Patients: Data of Patients From Turkey Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-05 Safak Ozer Balin, Mehmet Ali Aşan, Erhan Cahit Ozcan, Kader Uğur, Arzu Şenol
With the aging population, it is expected that diabetes and related complications will increase rapidly. The aim of this study was to examine the signs and symptoms of diabetic foot infection in el...
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The Role of Nutrients and Diet Characteristics in the Management of Diabetic Foot Ulcers: A Systematic Review Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-03 Kyriaki Apergi, Charilaos Dimosthenopoulos, Nikolaos Papanas
Diabetic foot ulcers (DFUs) are common complications of diabetes mellitus that affect patients’ quality of life and pose a burden on the healthcare system. Although malnutrition and specific nutrit...
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Clinical Features, Inflammatory Markers, and Limb Salvage in Older Adults with Diabetes-Related Foot Infections Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-02-01 Javier Aragón-Sánchez, Gerardo Víquez-Molina, María Eugenia López-Valverde, Cristina Aragón-Hernández, Javier Aragón-Hernández, José María Rojas-Bonilla
Little information exists about diabetic foot infections (DFIs) in older patients. We hypothesize that older patients with DFIs have different clinical features and worse outcomes than younger pati...
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Bibliometric Analysis: Bridging Informatics With Science Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-29 Miltos K. Lazarides, Irene-Zacharo Lazaridou, Nikolaos Papanas
Bibliometric analysis represents a new tool for classifying and quantitatively assessing bibliographic material (publications, citations, authors, institutions, etc) of a scientific discipline. Is ...
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Platelet-rich Plasma (PRP) in the Treatment of Diabetic Foot Ulcers and its Regulation of Autophagy Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-18 Pengyu Zhao, Guofu Zhou, Jinglun Jiang, Hong Li, Xiaoyan Xiang
Objective: Through clinical trials, this study observes the therapeutic effect of platelet-rich plasma (platelet-rich plasma, PRP) on diabetic foot ulcers and explored the relationship between the ...
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Efficacy of Chinese and Western Medical Techniques in Treating Diabetic Foot Ulcers With Necrotizing Fasciitis of the Lower Leg Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-17 Yongchong Chen, Yunzhu Wang, TaiAn Zhang, Chao Meng, Qing Li, Bohui Zhang, Kai Zhang, Chunfang Qin
To analyze and evaluate the clinical efficacy of Chinese and Western medical techniques in the treatment of severe diabetic foot ulcers complicated with necrotizing fasciitis of the lower leg and s...
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A 12-Week Supervised Exercise Therapy Program for Patients with Diabetic Foot Ulcers: Program Development and Preliminary Feasibility Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-05 Thomas Vedste Aagaard, Kajsa Lindberg, Stig Brorson, Ulla Riis Madsen, Søren T. Skou
Exercise therapy helps improve glycaemic control and insulin sensitivity and may be relevant in treating patients with diabetic foot ulcers (DFUs). This study describes the development of a 12-week...
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Effects of Citric Acid on the Healing Process of Chronic Wound due to Leprosy Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-05 Jessica Rodrigues dos Passos, Carine Teles Sangaleti, Maria Regiane Trincaus, Kelly Holanda Prezotto, Lucas de Oliveira Araújo, Basilio Techy, Tatiane Baratieri, Maicon Henrique Lentsck, Guilherme Ribas Taques, Ricardo Castanho Moreira, Dannyele Cristina da Silva
Objective: The aim was to describe the effects of the use of citric acid in the healing process of chronic leprosy wounds. Approach: This is a case series, carried out with 5 people with chronic le...
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Factors Associated With Self-Efficacy of Foot Self-Care Among Patients With Diabetes Attending a Tertiary Care Center in Saudi Arabia Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-03 Musab Yousef Al Ayed, Anas Ababneh, Asirvatham Alwin Robert, Rania Ahmed, Ibrahim Al Ghofaili, Abdulghani Al Saeed, Mohamed Abdulaziz Al Dawish
Several reports have shown self-efficacy to be a reliable way of predicting foot self-care behavior in patients with diabetes. However, at a global level in general, and in Saudi Arabia in particul...
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An Integrated Systemic and Local Wound Management in Recalcitrant Pyoderma Gangrenosum Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-03 Giorgia Salvia, Alessandra Michelucci, Giammarco Granieri, Flavia Manzo Margiotta, Matteo Bevilacqua, Cristian Fidanzi, Salvatore Panduri, Marco Romanelli, Valentina Dini
Pyoderma gangrenosum (PG) is a neutrophilic inflammatory dermatosis, whose management still represents a clinical challenge due to frequent unresponsive cases. The aim of our study was to evaluate ...
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Acute Effects of Combination Therapy by Triceps Surae Stretching and Electrical Stimulation to the Tibialis Anterior on Medial Forefoot Plantar Pressure During Gait in Patients With Diabetes Mellitus Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2023-01-03 Noriaki Maeshige, Maiki Moriguchi, Miki Fujii, Hoshinori Kanazawa, Yoshiyuki Yoshikawa, Kazuya Kitamura, Fumiya Okuno, Atomu Yamaguchi, Mikiko Uemura, Masashi Hosomi, Kenta Hara, Hiroto Terashi, Hidemi Fujino
High plantar flexor moment and limited ankle mobility are known to cause high plantar pressure under the forefoot. Stretching is an effective physical therapy for the limited ankle range of motion ...
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Analysis of Energy and Density in Treating Hypertrophic Scar After Burn in Children with CO2 Dot Matrix Laser Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-12-19 Zhi-bo Zhang, Zhu-liang Zhou, Fu-xi Xing, Yong Li, Xing-chen Sun, Yu-ting Zhao, Xiang-zhou Zhang, Ji-song Liu
Objective: To analyze and compare the effect of the combination of energy and density parameters of CO2 dot matrix laser in the hyperplastic stage of pediatric burn. Materials and Methods: A total ...
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Topical Turmeric Ointment in the Treatment of Diabetic Foot Ulcers: A Randomized, Placebo-Controlled Study Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-12-13 Mohsen Agharazi, Sasan Gazerani, Mark Kenneth Huntington
Diabetic foot is a serious complication of diabetes which has significant medical and socioeconomic impacts. Turmeric is a popular Indian spice that has been used for centuries in herbal medicines ...
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Negative Pressure Wound Therapy: Supra-Physiological or Just Physical Effects of Positive Pressure? Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-12-07 Valdas Macionis
This communication provides a new insight into the unexplained physiology of beneficial effects of negative pressure wound therapy (NPWT). Possible mechanisms of beneficial effects of NPWT in faili...
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The Impact of Diabetes in Intermittent Claudication: A Prospective Cohort Study Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-12-01 Anabelle Mizzi, Kevin Cassar, Catherine J. Bowen, Liberato Camilleri, Cynthia Formosa
The aim of this study was to determine the lower-limb outcome in patients with intermittent claudication (IC) and to identify predictors for deterioration. This study employed a prospective observa...
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Vitamin B12 and Diabetic Foot: Α Mini-Review Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-11-29 Nikolaos D. Karakousis, Elisavet E. Pyrgioti, Petros N. Georgakopoulos, Nikolaos Papanas
This narrative mini-review article aimed to investigate the potential association of vitamin B12 levels with diabetic neuropathy (DN) and diabetic foot ulcers (DFUs). It was demonstrated that B12 d...
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Pyoderma Gangrenosum Triggered by COVID-19 Vaccination in a Patient with Ulcerative Colitis: A Case Report Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-11-25 Yoon-Chung Kim, Hyung Sup Shim, Howon Jeong, Yune-Jung Park
Pyoderma gangrenosum (PG) is a rare inflammatory skin disease that is difficult to diagnose. PG may be an extra-intestinal manifestation of ulcerative colitis (UC). In recent times, coronavirus dis...
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Cutaneous Blastomycosis Presenting as a Nonhealing Wound in the Northeast United States: A Case Report Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-11-25 Hemali Shah, Teresa Carstensen, Michel Kmeid, Christie Bialowas
Primary cutaneous blastomycosis is a rare presentation of infection caused by direct inoculation of a wound. We present a 61-year-old male with an extensive history of wound dehiscence and wound ca...
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Factors Associated with Infection Severity of Diabetic Foot Ulcers: A Cross-Sectional Study Int. J. Low. Extrem. Wounds (IF 1.7) Pub Date : 2022-11-21 YiXin Luo, ShaoNa Niu, LiFang Mai, XingZhou Liu, Chuan Yang
Background: Infection in the ulcerated foot is a foremost cause of morbidity, constituting the biggest proportion of hospitalization and amputation among patients with diabetic foot ulcers. Assessm...