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Was antiviral prophylaxis necessary after kidney transplantation utilizing HBcAb+ donors? A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2024-03-12 Saifu Yin, Xiaoting Chen, Xingxing Li, Fan Zhang, Jiapei Wu, Tao Lin
Current guidelines lack consensus on whether antiviral prophylaxes should be administered after kidney transplantation from HBcAb+ donors. This systematic review and meta-analysis aimed to evaluate the incidence and risk factors of de novo HBV (DNH) infection, as well as graft and patient survival. We searched PubMed, Embase, and the Cochrane Library up to December 31, 2023. We included relevant studies
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The role of echocardiographic assessment for the risk of adverse events in liver transplant recipients: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2024-02-22 Quirino Lai, Miriam Caimano, Francesca Canale, Lucia Ilaria Birtolo, Flaminia Ferri, Stefano Ginanni Corradini, Massimo Mancone, Giuseppe Marrone, Daniela Pedicino, Massimo Rossi, Elisabetta Vernole, Maurizio Pompili, Marco Biolato
Echocardiographic findings may provide valuable information about the cardiac conditions in cirrhotic patients waiting for liver transplantation (LT). However, data on the ability of the different echocardiographic parameters to predict post-transplant risk of mortality are scarce and heterogeneous. This systematic review evaluates the role of different echocardiographic features as predictors of post-LT
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Post-transplant lymphoproliferative disorders following kidney transplantation: A literature review with updates on risk factors, prognostic indices, screening strategies, treatment and analysis of donor type Transplant. Rev. (IF 4.0) Pub Date : 2024-02-22 Mehmet Ergisi, Bryan Ooi, Omar Salim, Vassilios Papalois
Post-transplant lymphoproliferative disorders (PTLD) is a devastating complication of kidney transplantation with an insidious presentation and potential to disseminate aggressively. This review delineates the risk factors, prognostic indexes, screening, current management algorithm and promising treatment strategies for PTLD. Kidneys from both extended criteria donors (ECD) and living donors (LD)
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Recurrent C3 glomerulopathy after kidney transplantation Transplant. Rev. (IF 4.0) Pub Date : 2024-02-21 Shota Obata, Pedro A.S. Vaz de Castro, Leonardo V. Riella, Paolo Cravedi
The complement system is part of innate immunity and is pivotal in protecting the body against pathogens and maintaining host homeostasis. Activation of the complement system is triggered through multiple pathways, including antibody deposition, a mannan-binding lectin, or activated complement deposition. C3 glomerulopathy (C3G) is a rare glomerular disease driven by complement dysregulation with high
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Prehabilitation in patients awaiting liver transplantation Transplant. Rev. (IF 4.0) Pub Date : 2024-02-15 Amine Benmassaoud, Myriam Martel, Franco Carli, Olivia Geraci, Stella S. Daskalopoulou, Giada Sebastiani, Amal Bessissow
Frailty, malnutrition and sarcopenia lead to a significant increase in morbidity and mortality before and after liver transplantation (LT). Prehabilitation attempts to optimize physical fitness of individuals before major surgeries. To date, little is known about its impact on patients awaiting LT. The aim of our scoping review was to describe whether prehabilitation in patients awaiting LT is feasible
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Assessing quality of life in solid organ transplant recipients: A systematic review of the development, content, and quality of available condition- and transplant-specific patient-reported outcome measures Transplant. Rev. (IF 4.0) Pub Date : 2024-02-13 Ben Rimmer, Rebeka Jenkins, Siân Russell, Dawn Craig, Linda Sharp, Catherine Exley
We aimed to identify the condition- and transplant-specific patient-reported outcome measures (PROMs) available to measure quality of life (QoL) in solid organ transplant (SOT) recipients, examine their development and content, and critically appraise the quality of their measurement properties, to inform recommendations for clinical and research use. We systematically searched MEDLINE, Embase, CINAHL
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The effect of goal-directed fluid therapy on delayed graft function in kidney transplant recipients: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2024-02-05 Michael P. Klonarakis, Mannat Dhillon, Emir Sevinc, Meghan J. Elliott, Matthew T. James, Ngan N. Lam, Kevin J. McLaughlin, Paul E. Ronksley, Shannon M. Ruzycki, Tyrone G. Harrison
Delayed graft function (DGF) is a common post-operative complication with potential long-term sequelae for many kidney transplant recipients, and hemodynamic factors and fluid status play a role. Fixed perioperative fluid infusions are the standard of care, but more recent evidence in the non-transplant population has suggested benefit with goal-directed fluid strategies based on hemodynamic targets
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Latest advances in frailty in kidney transplantation: A narrative review Transplant. Rev. (IF 4.0) Pub Date : 2024-01-24 Ruth Fergie, Alexander P. Maxwell, Emma L. Cunningham
Frailty is a clinical syndrome that is characterised by decline in multiple systems with associated decreased physiological reserve and ability to respond to stressor events. It is associated with greater healthcare burden. It is common in patients with end-stage renal disease (ESRD). Kidney transplantation is considered the optimal form of renal replacement therapy for suitable patients with ESRD
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The psychology, legality, ethics and medical aspects of organ donation by minors Transplant. Rev. (IF 4.0) Pub Date : 2024-01-19 A. Ashwin, S.D. Cherukuri, A. Rammohan
Any individual who has not attained the chronological age of legal majority as per national law is termed a minor. The concept of living donation (LD) has always been a subject of ethical debate and further compounding the controversy is the question of LD by minors. The decision for a minor to donate poses a special challenge as it involves a close family unit of parent-child relationship. Such an
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miRNA as potential biomarkers after liver transplantation: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2024-01-14 Pia F. Koch, Kristina Ludwig, Felix Krenzien, Karl H. Hillebrandt, Wenzel Schöning, Johann Pratschke, Nathanael Raschzok, Igor M. Sauer, Simon Moosburner
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Immunosuppression for older liver transplant recipients Transplant. Rev. (IF 4.0) Pub Date : 2023-12-16 Paolo De Simone, Sara Battistella, Quirino Lai, Juri Ducci, Francesca D'Arcangelo, Piero Marchetti, Francesco Paolo Russo, Patrizia Burra
Older liver transplant recipients have a lower risk of acute rejection than younger patients (9% for patients aged ≥65 years versus 23% for those aged 18–34 years) and are more vulnerable to immunosuppression-related complications. The number of liver transplant recipients ≥65 years has risen to 22% in Europe and the US, but limited information is available on the optimal immunosuppressive regimen
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The applications of ECMO in liver transplant recipients Transplant. Rev. (IF 4.0) Pub Date : 2023-12-13 Yue Qiu, Ibtesam Hilmi
Extracorporeal membrane oxygenation (ECMO) has emerged as a vital instrument for sustaining respiratory and cardiac functions when traditional methods have failed. Its function in managing acute pulmonary and cardiac challenges during liver transplantation (LT) has expanded significantly. While ECMO was initially viewed as a rescue strategy for acute intraoperative or posttransplant complications,
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The association between tacrolimus exposure and tremor, headache and insomnia in adult kidney transplant recipients: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-12-07 Catherine P. King, Amelia R. Cossart, Nicole M. Isbel, Scott B. Campbell, Christine E. Staatz
Purpose Tremor, headache and insomnia have been linked to the immunosuppressant, tacrolimus. The aim of this systematic review was to determine if there is a correlation between tacrolimus exposure and new-onset tremor, headache and insomnia experienced by adult kidney transplant recipients. Methods PubMed, Embase, Cochrane Library and CINAHL databases were searched up to 11 April 2023 for published
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Disparities in kidney transplantation accessibility among immigrant populations in Europe: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-12-01 Pieter A.H. van Overdijk, Alessandra A. Grossi, Céline H. van Delft, Nichon E. Jansen, Martijn W.F. van den Hoogen, David Paredes-Zapata
Background and objectives Disparities in access to healthcare for patients with an immigration background are well-known. The aim of this study was to determine whether disparities among immigrant populations translate into a relative difference in the number of kidney transplants (KT) performed in documented immigrant patients (first and second generation) relative to native-born patients in Europe
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Graft retrieval incisions in minimally invasive donor nephrectomy: Systematic review and network meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-11-14 Khi Yung Fong, Joshua Chek Hao Foo, Yiong Huak Chan, Edwin Jonathan Aslim, Lay Guat Ng, Valerie Huei Li Gan, Ee Jean Lim
Background Various incisions are employed for graft extraction during minimally invasive donor nephrectomy, but an overarching synthesis of associated short-term donor outcomes is lacking. Methods An electronic literature search was conducted on PubMed, EMBASE and Scopus for studies comparing ≥2 graft extraction incisions in laparoscopic or robotic donor nephrectomy with ≥10 patients per arm. Eligible
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Incidence of refractory CMV infection with or without antiviral resistance in Spain: A systematic literature review Transplant. Rev. (IF 4.0) Pub Date : 2023-11-06 J.M. Aguado, D. Navarro, C. Montoto, M. Yébenes, I. de Castro-Orós
Introduction Solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) recipients are susceptible to cytomegalovirus (CMV) infection. The incidence of refractoriness to antivirals, with or without resistance, is unclear. The purpose of this review was to describe the epidemiology of refractory CMV infection in Spain to understand the current unmet needs. Methods PubMed, EMBASE
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The British Transplantation Society guidelines on ethics, law and consent in relation to deceased donors after circulatory death Transplant. Rev. (IF 4.0) Pub Date : 2023-10-26 Greg Moorlock, Ellie Asgari, Chris Callaghan, Heather Draper, Peter Dupont, Patty Gilbert, David Nasralla, Peter Veitch, Chris Watson, Stephen O'Neill
The British Transplantation Society (BTS) ‘Guideline on transplantation from deceased donors after circulatory death’ has recently been updated and this manuscript summarises the relevant recommendations from chapters specifically related to law, ethics, donor consent and informing the recipient.
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Progress in preservation of intestinal grafts by oxygenated hypothermic machine perfusion Transplant. Rev. (IF 4.0) Pub Date : 2023-10-15 Shuang Yang, Wen Hou, Lei Liu
Intestine transplantation (IT) is a critical treatment strategy for irreversible intestinal failure. Among all abdominal solid organ transplants, the intestine was the most vulnerable to ischemia and reperfusion injury (IRI). The static cold storage (SCS) technique is currently the most commonly used graft preservation method, but its hypoxia condition causes metabolic disorders, resulting in the occurrence
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Non-tuberculous mycobacteria disease pre-lung transplantation: A systematic review of the treatment regimens and duration pre- and post-transplant. Transplant. Rev. (IF 4.0) Pub Date : 2023-10-07 Johanna P. van Gemert, Sofanne J. Ravensbergen, Erik A.M. Verschuuren, Huib A.M. Kerstjens, Brigitte W.M. Willemse, Jakko van Ingen, Wouter Hoefsloot, Tji Gan, Onno W. Akkerman
Background There is lack of consensus on non-tuberculous mycobacteria pulmonary disease (NTM-PD) treatment regimen and duration in patient listed for lung transplantation (LTx). We conducted a systematic review on treatment regimen and duration pre- and directly post-LTx, for patients with known NTM-PD pre-LTx. Additionally, we searched for risk factors for NTM disease development post-LTx and for
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British Transplantation Society guidelines on abdominal organ transplantation from deceased donors after circulatory death Transplant. Rev. (IF 4.0) Pub Date : 2023-10-11 Benedict Phillips, Ellie Asgari, Miriam Berry, Chris Callaghan, Miriam Cortes Cerisuelo, Paul Johnson, Nikolaos Karydis, David Nasralla, Anisa Nutu, Gabi Oniscu, Thamara Perera, Sanjay Sinha, Andrew Sutherland, David Van Dellen, Chris Watson, Steve White, Stephen O'Neill
The British Transplantation Society (BTS) ‘Guideline on transplantation from deceased donors after circulatory death’ has recently been updated and this manuscript summarises the relevant recommendations in abdominal organ transplantation from Donation after Circulatory Death (DCD) donors, encompassing the chapters on liver, kidney, pancreas and islet cell transplantation.
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Preoperative fibrinogen level and blood transfusions in liver transplantation: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-09-26 Félix Thibeault, Guillaume Plourde, Massine Fellouah, Daniela Ziegler, François Martin Carrier
Background Orthotopic liver transplantation (OLT) is a major surgery often associated with significant bleeding. We conducted a systematic review to explore the association between preoperative fibrinogen level and intraoperative blood products transfusion, blood loss and clinical outcomes in patients undergoing OLT. Methods We included observational studies conducted in patients undergoing an OLT
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Management of an aneurysmal arteriovenous fistula in kidney transplant recipients Transplant. Rev. (IF 4.0) Pub Date : 2023-09-29 Michael Corr, Kateřina Lawrie, Peter Baláž, Stephen O'Neill
Aneurysms remain the most common complication of an arteriovenous fistula created for dialysis access. The management of an aneurysmal arteriovenous fistula (AAVF) in kidney transplant recipients remains contentious with a lack of clear clinical guidelines. Recipients of a functioning graft do not require the fistula for dialysis access, however risk of graft failure and needing the access at a future
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What are the benefits of preemptive versus non-preemptive kidney transplantation? A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-09-28 Reshma Rana Magar, Simon R. Knight, Umberto Maggiore, Jeffrey A. Lafranca, Frank J.M.F. Dor, Liset H.M. Pengel
Opting for a preemptive kidney transplant (PKT) can help avoid costs and morbidity associated with dialysis. However, while multiple studies have shown clinical benefits of PKT, other studies have not demonstrated this, leading to controversy in the literature regarding the exact benefits of PKT. Therefore, this study aimed to determine the clinical outcomes of PKT versus non-preemptive kidney transplantation
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Pulmonary and esophageal function in lung transplantation: Fundamental principles and clinical application Transplant. Rev. (IF 4.0) Pub Date : 2023-09-26 Andrés R. Latorre-Rodríguez, Deepika Razia, Ashraf Omar, Ross M. Bremner, Sumeet K. Mittal
The lungs and esophagus have a close anatomical and physiological relationship. Over the years, reflux-induced pulmonary injury has gained wider recognition, but the full effects of pulmonary disease on esophageal function are still unknown. Intrathoracic pressure dynamics potentially affect esophageal function, especially in patients with end-stage lung disease, both obstructive and restrictive. Lung
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The use of lymphocyte-depleting antibodies in specific populations of kidney transplant recipients: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-09-21 Nuria Montero, Emilio Rodrigo, Marta Crespo, Josep M. Cruzado, Alex Gutierrez-Dalmau, Auxiliadora Mazuecos, Asunción Sancho, Lara Belmar, Emma Calatayud, Paula Mora, Laia Oliveras, Eulalia Solà, Florentino Villanego, Julio Pascual
Background Recommendations of the use of antibody induction treatments in kidney transplant recipients (KTR) are based on moderate quality and historical studies. This systematic review aims to reevaluate, based on actual studies, the effects of different antibody preparations when used in specific KTR subgroups. Methods We searched MEDLINE and CENTRAL and selected randomized controlled trials (RCT)
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The British Transplantation Society guidelines on cardiothoracic organ transplantation from deceased donors after circulatory death Transplant. Rev. (IF 4.0) Pub Date : 2023-08-30 Vasudev Pai, Ellie Asgari, Marius Berman, Chris Callaghan, Paul Corris, Stephen Large, Simon Messer, David Nasralla, Jas Parmar, Chris Watson, Stephen O'Neill
Maximising organ utilisation from donation after circulatory death (DCD) donors could help meet some of the shortfall in organ supply, but it represents a major challenge, particularly as organ donors and transplant recipients become older and more medically complex over time. Success is dependent upon establishing common practices and accepted protocols that allow the safe sharing of DCD organs and
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Efficacy of denosumab on bone metabolism and bone mineral density in renal transplant recipients: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-08-26 Peiqin Zhu, Tong Yang, Jun Le, Xiaoting Fu, Liang Zhang
Background Post-transplant bone disease (PTBD) is a common complication in kidney transplant recipients. This systematic review and meta-analysis evaluates the efficiency and safety of denosumab for the treatment of PTBD in kidney transplant recipients. Methods Comprehensive search of PubMed Central, SCOPUS, EMBASE, MEDLINE, Cochrane trial registry, Google Scholar, and Clinicaltrials.gov databases
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The British transplantation society guidelines on organ donation from deceased donors after circulatory death Transplant. Rev. (IF 4.0) Pub Date : 2023-08-15 Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson
Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can compare favourably and even match recipient outcomes after transplantation with organs from donation after brain death donors. Success is dependent upon establishing common practices and accepted protocols that allow the safe sharing of DCD organs and maximise the use of the DCD donor pool. The
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Hematopoietic cell-based and non-hematopoietic cell-based strategies for immune tolerance induction in living-donor renal transplantation: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-08-19 Chandrashekar Annamalai, Vivek Kute, Carl Sheridan, Ahmed Halawa
Introduction Despite its use to prevent acute rejection, lifelong immunosuppression can adversely impact long-term patient and graft outcomes. In theory, immunosuppression withdrawal is the ultimate goal of kidney transplantation, and is made possible by the induction of immunological tolerance. The purpose of this paper is to review the safety and efficacy of immune tolerance induction strategies
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Minimally and Non-invasive Approaches to Rejection Identification in Vascularized Composite Allotransplantation Transplant. Rev. (IF 4.0) Pub Date : 2023-08-16 Thor S. Stead, Hilliard T. Brydges, Matteo Laspro, Ogechukwu C. Onuh, Bachar F. Chaya, Piul S. Rabbani, Catherine P. Lu, Daniel J. Ceradini, Bruce E. Gelb, Eduardo D. Rodriguez
Objective Rejection is common and pernicious following Vascularized Composite Allotransplantation (VCA). Current monitoring and diagnostic modalities include the clinical exam which is subjective and biopsy with dermatohistopathologic Banff grading, which is subjective and invasive. We reviewed literature exploring non- and minimally invasive modalities for diagnosing and monitoring rejection (NIMMs)
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Executive summary of the consensus statement of the group for the study of infection in transplantation and other immunocompromised host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the treatment of SARS-CoV-2 infection in solid organ transplant recipients Transplant. Rev. (IF 4.0) Pub Date : 2023-08-11 Sabina Herrera, José M. Aguado, Francisco Javier Candel, Elisa Cordero, Beatriz Domínguez-Gil, Mario Fernández-Ruiz, Ibai Los Arcos, Òscar Len, M. Ángeles Marcos, Elena Muñez, Patricia Muñoz, Isabel Rodríguez-Goncer, Javier Sánchez-Céspedes, Maricela Valerio, Marta Bodro
Abstract not available
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Living donor robotic-assisted kidney transplant compared to traditional living donor open kidney transplant. Where do we stand now? A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-08-11 Mario A. O'Connor-Cordova, Alan G. Ortega-Macias, Juan P. Sancen-Herrera, Francisco Altamirano-Lamarque, Alexis Vargas del Toro, Andres Inzunza Martin del Campo, Pia Canal-Zarate, Bharat Kumar Peddinani, Fernando Gonzalez-Zorrilla, Mario O'Connor Juarez
Background Renal transplant is the standard of care for patients with end-stage renal disease (ESRD). Robotic-assisted kidney transplant (RAKT) has emerged as a safe minimally invasive approach with a lower complication rate than open kidney transplant (OKT). Concerns regarding ischemia times and graft function are still a matter of debate. Methods Following PRISMA guidelines and PROSPERO registration
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Immunosuppression of HLA identical living-donor kidney transplant recipients: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-08-01 María José Pérez-Sáez, Núria Montero, Laia Oliveras, Dolores Redondo-Pachón, David Martínez-Simón, Daniel Abramovicz, Umberto Maggiore, Christophe Mariat, Geir Mjoen, Gabriel C. Oniscu, Licia Peruzzi, Mehmet Sükrü Sever, Bruno Watschinger, Arzu Velioglu, Erol Demir, Ilaria Gandolfini, Rachel Hellemans, Luuk Hilbrands, Julio Pascual, Marta Crespo
Background Kidney transplant (KT) recipients of HLA identical siblings (HLAid) have lower immunological risk, but there are no specific recommendations for immunosuppression. Our aim was to analyze evidence about results from HLAid living-donor recipients under different immunosuppression in the current era of immunological risk assessment. Methods Systematic review of studies describing associations
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Serum uric acid levels in kidney transplant recipients: A cause for concern? A review of recent literature Transplant. Rev. (IF 4.0) Pub Date : 2023-07-06 Uyi Jefferson Imasuen, Kurtis J. Swanson, Sandesh Parajuli
The impact of elevated serum uric acid levels i.e., hyperuricemia, on native and transplant chronic kidney disease progression has been debated. This literature review presents an analysis of multiple studies exploring the relationship between serum uric acid levels and kidney transplant outcomes. The review includes a summary of the pathophysiology of hyperuricemia and gout, a review of urate-lowering
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Diagnostic accuracy of brain natriuretic peptide and N-terminal-pro brain natriuretic peptide to detect complications of cardiac transplantation in adults: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-07-04 Victor Zhu, Luke A. Perry, Mark Plummer, Reny Segal, Julian Smith, Zhengyang Liu
Background We aimed to evaluate the utility of BNP and NT-proBNP in identifying adverse recipient outcomes following cardiac transplantation. Methods We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Library from inception to February 2023. We included studies reporting associations between BNP or NT-proBNP and adverse outcomes following cardiac transplantation in adults. We calculated standardised
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Bariatric surgery improves access to renal transplantation and is safe in renal failure as well as after transplantation: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-07-08 J.T.S. Fernando, J.R. Varma, F. Dengu, V. Menon, S. Malik, J.M. O'Callaghan
Introduction Effective workup and listing of end-stage renal disease (ESRD) patients for renal transplantation, often with multiple co-morbidities, poses a challenge for transplant teams. Obesity is a common co-morbidity associated with adverse outcomes in ESRD and kidney transplant (KT) recipients. Bariatric and metabolic surgery (BMS) has long been established as a safe and effective treatment for
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Inhibitory innate receptors and their potential role in transplantation Transplant. Rev. (IF 4.0) Pub Date : 2023-07-07 Karina Lima, Guilherme T. Ribas, Leonardo V. Riella, Thiago J. Borges
The regulatory arm of the immune system plays a crucial role in maintaining immune tolerance and preventing excessive immune responses. Immune regulation comprises various regulatory cells and molecules that work together to suppress or regulate immune responses. The programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) are examples of inhibitory receptors
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Rescue liver transplantation after post-hepatectomy acute liver failure: A systematic review and pooled analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-06-17 Roberta Angelico, Leandro Siragusa, Matteo Serenari, Irene Scalera, Emanuele Kauffman, Quirino Lai, Alessandro Vitale
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Current and future role of double-lung transplantation for bilateral lung cancer Transplant. Rev. (IF 4.0) Pub Date : 2023-06-17 Jeeyeon Lee, Samuel J. Schellenberg, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae
Technological advances have progressively enhanced the survival rate of lung transplant recipients and expanded its indications for various diseases, including the recent coronavirus disease 2019 (COVID-19). However, according to the International Society for Heart and Lung Transplantation, lung cancer constituted a mere 0.1% of the indications for lung transplantation over the past two decades. This
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Treatment of hepatocellular carcinoma with macroscopic vascular invasion: A systematic review and network meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-06-05 Francisco Tustumi, Fabricio Ferreira Coelho, Daniel de Paiva Magalhães, Sérgio Silveira Júnior, Vagner Birk Jeismann, Gilton Marques Fonseca, Jaime Arthur Pirola Kruger, Luiz Augusto Carneiro D'Albuquerque, Paulo Herman
Background This study aimed to evaluate the outcomes of different treatments for patients with hepatocellular carcinoma (HCC) and macroscopic vascular invasion. Methods A systematic review and meta-analysis of comparative studies was performed to evaluate various treatment modalities for HCC with macroscopic vascular invasion, including liver resection (LR), liver transplantation (LT), transarterial
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Ventilation during ex vivo lung perfusion, a review Transplant. Rev. (IF 4.0) Pub Date : 2023-04-18 Sue A. Braithwaite, Elise van Hooijdonk, Niels P. van der Kaaij
Evidence suggests that ventilation during ex vivo lung perfusion (EVLP) with a ‘one-size-fits-all’ strategy has the potential to cause lung injury which may only become clinically relevant in marginal lung allografts. EVLP induced- or accelerated lung injury is a dynamic and cumulative process reflecting the interplay of a number of factors. Stress and strain in lung tissue caused by positive pressure
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Perspectives and experiences of kidney transplant recipients with graft failure: A systematic review and meta-synthesis Transplant. Rev. (IF 4.0) Pub Date : 2023-04-13 Katya Loban, Anna Horton, Jorane-Tiana Robert, Lindsay Hales, Sandesh Parajuli, Mara McAdams-DeMarco, Shaifali Sandal
Background Kidney transplant recipients with graft failure are a rapidly rising cohort of patients who experience high morbidity, mortality, and fragmented transitions of care between transplant and dialysis teams. Current approaches to improving care focus on medical and surgical interventions, increasing re-transplantation, and improving coordination between treating teams with little understanding
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Trends in systematic reviews of kidney transplantation: A 10-year analysis of the evidence base Transplant. Rev. (IF 4.0) Pub Date : 2023-04-05 Sarah Salih, John O'Callaghan, Marwah Salih, James Walker, Reshma Rana Magar, Simon Knight, Liset H.M. Pengel
Background Systematic reviews (SRs) are the highest form of evidence for all types of clinical questions in evidence-based practice. For the first time in 2018, the number of SRs in transplantation outstripped those from randomised controlled trials (RCTs). This raises concerns of duplication or increased use of non-RCT evidence. We aimed to analyse the trends, strength and quality of SRs in kidney
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Can eHealth applications improve renal transplant outcomes for adolescents and young adults? A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-04-07 Kim C.M. Bul, Christopher Bannon, Nithya Krishnan, Amber Dunlop, Ala Szczepura
Background and Objectives Adherence to medical treatment following a kidney transplant is particularly challenging during adolescence and young adulthood. There is increasing evidence of the benefits of the use of computer and mobile technology (labelled as eHealth hereafter) including serious gaming and gamification in many clinical areas. We aimed to conduct a systematic review of such interventions
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Incidence, predictors and outcomes of new onset systolic heart failure following orthotopic liver transplant: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2023-03-27 Amrin Kharawala, Israel Safiriyu, Adebolu Olayinka, Adrija Hajra, Jiyoung Seo, Harriet Akunor, Majd Al Deen Alhuarrat, Rosy Thachil
Background New onset Systolic heart failure (SHF), characterized by new onset left ventricular (LV) systolic dysfunction with a reduction in ejection fraction (EF) of <40%, is a common cause of morbidity and mortality among Orthotopic liver transplant (OLT) recipients. Therefore, we aimed to evaluate the prevalence, the pre-transplant predictors, and the prognostic impact of SHF post-OLT. Methods We
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Factors associated with health inequities in access to kidney transplantation in the USA: A scoping review Transplant. Rev. (IF 4.0) Pub Date : 2023-03-11 Zachary Ernst, Andrew Wilson, Andriana Peña, Mitchell Love, Ty Moore, Matt Vassar
Background The kidney is the most needed organ for transplantation in the United States. However, demand and scarcity of this organ has caused significant inequities for historically marginalized groups. In this review, we report on the frequency of inequities in all steps of kidney transplantation from 2016 to 2022. Search criteria was based on the National Institute of Health's (NIH) 2022 list of
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Technical challenges in LDLT – Overcoming small for size syndrome and venous outflow reconstruction Transplant. Rev. (IF 4.0) Pub Date : 2023-02-27 Paola A. Vargas, Narmina Khanmammadova, Deniz Balci, Nicolas Goldaracena
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Outcomes from organ donation following medical assistance in dying: A scoping review Transplant. Rev. (IF 4.0) Pub Date : 2023-02-06 Vanessa Silva e Silva, Amina Silva, Andrea Rochon, Ken Lotherington, Laura Hornby, Tineke Wind, Jan Bollen, Lindsay C. Wilson, Aimee J. Sarti, Sonny Dhanani
Aim To collate and summarize the current international literature on the transplant recipient outcomes of organs from Medical Assistance in Dying (MAiD) donors, as well as the actual and potential impact of organ donation following MAiD on the donation and transplantation system. Background The provision of organ donation following MAiD can impact the donation and transplantation system, as well as
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Best practices during COVID-19 pandemic in solid organ transplant programs in Spain Transplant. Rev. (IF 4.0) Pub Date : 2023-02-03 Julio Pascual, Auxiliadora Mazuecos, Gloria Sánchez-Antolín, Amparo Solé, Pedro Ventura-Aguiar, Marta Crespo, Marta Farrero, Constantino Fernández-Rivera, Iris P. Garrido, Francisco Gea, Esther González-Monte, Antonio González-Rodríguez, Román Hernández-Gallego, Carlos Jiménez, Verónica López-Jiménez, Alejandra Otero, Sonia Pascual, Gonzalo P. Rodríguez-Laiz, Juan Carlos Ruiz, Asunción Sancho, Juan
Clinical management of transplant patients abruptly changed during the first months of COVID-19 pandemic (March to May 2020). The new situation led to very significant challenges, such as new forms of relationship between healthcare providers and patients and other professionals, design of protocols to prevent disease transmission and treatment of infected patients, management of waiting lists and
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The short- and long-term outcomes in living-donor liver transplantation using small-for-size graft: A systematic review and meta-analysis Transplant. Rev. (IF 4.0) Pub Date : 2023-02-03 Ki-Hun Kim, Sang-Hoon Kim, Hwui-Dong Cho
Background A standard graft-to-recipient weight ratio (GRWR) ≥0.8% is widely accepted in living-donor liver transplantation (LDLT); however, the potential donor pool is expanded to patients adopting small-for-size graft (SFSGs) with GRWR <0.8%. This study aimed to investigate the effect of SFSG on short- and long-term outcomes following LDLT. Methods Electronic databases were searched from January
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Alloimmune risk assessment for antibody-mediated rejection in kidney transplantation: A practical proposal Transplant. Rev. (IF 4.0) Pub Date : 2022-12-20 Laura Llinàs-Mallol, Dàlia Raïch-Regué, Julio Pascual, Marta Crespo
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Although an improvement in graft survival has been observed in the last decades with the use of different immunosuppressive drugs, this is still limited in time with antibody-mediated rejection being a main cause of graft-loss. Immune monitoring and risk assessment of antibody-mediated rejection before and
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Outcomes of live renal donors with a history of nephrolithiasis; A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2022-12-23 Mohamed Eftal Bin Mohamed Ebrahim, Animesh Singla, Jinna Yao, Jerome Martin Laurence, Germaine Wong, Howard Lau, Taina Lee, Lawrence Yuen, Wai H. Lim, Henry Pleass
The clinical outcomes of kidney donors with a prior history of nephrolithiasis are poorly defined. We conducted a systematic review assessing the post-donation clinical outcomes of kidney donors with a history of nephrolithiasis. Electronic databases (Ovid and Embase) were searched between 1960 and 2021 using key terms and Medical Subject Headings (MeSH) – nephrolithiasis, renal stones, renal transplantation
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Progress of research on human parvovirus B19 infection after renal transplantation Transplant. Rev. (IF 4.0) Pub Date : 2022-11-06 Yuhua Ma, Jiangwei Man, Jiping Niu, Li Yang
Long-term immunosuppressant use in renal transplant recipients leads to dampened immune function and high susceptibility to opportunistic pathogens. Recently, the incidence of human parvovirus B19 (HPV-B19) infection after renal transplantation has increased, which may lead to pure red cell aplasia (PRCA), affect graft function, and lead to renal injury. After renal transplantation, the clinical manifestations
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Use of sodium-glucose co-transporter 2 inhibitors in solid organ transplant recipients with pre-existing type 2 or post-transplantation diabetes mellitus: A systematic review Transplant. Rev. (IF 4.0) Pub Date : 2022-11-04 Yolanda Lin, Merisa Mok, Jennifer Harrison, Marisa Battistella, Ashley Farrell, Marianna Leung, Catherine Cheung
Introduction Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitors have demonstrated kidney, cardiovascular and mortality benefits in the general population; however, the evidence is limited in solid organ transplant recipients. The aim of this systematic review was to evaluate the current efficacy and safety data of SGLT2 inhibitors in adult kidney, heart, lung, and liver transplant recipients with pre-existing