样式: 排序: IF: - GO 导出 标记为已读
-
Normothermic machine perfusion for liver transplantation: current state and future directions. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-03-15 Jessica Lindemann, Jennifer Yu, Mb Majella Doyle
The number of patients on the liver transplant waitlist continues to grow and far exceeds the number of livers available for transplantation. Normothermic machine perfusion (NMP) allows for ex-vivo perfusion under physiologic conditions with the potential to significantly increase organ yield and expand the donor pool.
-
Squaring the Circle. Brain death and organ transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-03-15 Howard R Doyle
The adoption of brain death played a crucial role in the development of organ transplantation, but the concept has become increasingly controversial. This essay will explore the current state of the controversy and its implications for the field.
-
Expanding MELD exceptions for colorectal liver metastasis: data and policy. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-03-15 Jenna N Whitrock, Catherine G Pratt, Shimul A Shah
While liver transplant for unresectable colorectal cancer liver metastases (CRLM) has been demonstrated to be a promising treatment in selected patients, the typically low MELD score of these patients and lack of exception points may lead to challenges in receiving a deceased donor liver for transplant.
-
Thoraco-abdominal normothermic regional perfusion for thoracic transplantation in the United States: current state and future directions. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-03-15 Swaroop Bommareddi, Brian Lima, Ashish S Shah, John M Trahanas
To provide an update regarding the state of thoracoabdominal normothermic regional perfusion (taNRP) when used for thoracic organ recovery.
-
Normothermic regional perfusion procurement for abdominal organ donors: techniques and troubleshooting. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-03-12 Stephanie Silpe, Eric Martinez, Anji Wall
Normothermic regional perfusion (NRP) is a novel procurement technique for donation after circulatory death (DCD) in the United States. It was pioneered by cardiothoracic surgery programs and is now being applied to abdominal-only organ donors by abdominal transplant programs. Multiple technical approaches can be used for abdominal-only NRP DCD donors and this review describes these techniques.
-
Recent advances in cytomegalovirus infection management in solid organ transplant recipients. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-01-31 Paolo Antonio Grossi, Maddalena Peghin
Human cytomegalovirus (CMV) continues to be the most important infectious complication following solid organ transplantation (SOT).
-
Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-01-24 Pablo Achurra, Eduardo Fernandes, Grainne O'Kane, Robert Grant, Mark Cattral, Gonzalo Sapisochin
Using transplant oncology principles, selected patients with intrahepatic cholangiocarcinoma (iCCA) may achieve long-term survival after liver transplantation. Strategies for identifying and managing these patients are discussed in this review.
-
Urine CXCL10 as a biomarker in kidney transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-01-19 Patricia Hirt-Minkowski, Stefan Schaub
Urine CXCL10 is a promising biomarker for posttransplant renal allograft monitoring but is currently not widely used for clinical management.
-
Bacterial infections in solid organ transplant recipients. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2024-01-12 Johan Courjon, Dionysios Neofytos, Christian van Delden
Bacteria are the leading cause of infections in solid organ transplant (SOT) recipients, significantly impacting patient outcome. Recently detailed and comprehensive epidemiological data have been published.
-
Advances in desensitization for human leukocyte antigen incompatible kidney transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-14 Ashley Vo, Noriko Ammerman, Stanley C Jordan
Human leukocyte antigen (HLA) sensitization is a major barrier to kidney transplantation induced by exposure to alloantigens through pregnancy, blood product exposure and previous transplantations. Desensitization strategies are undertaken to improve the chances of finding compatible organ offers. Standard approaches to desensitization include the use of plasmapheresis/low dose intravenous immunoglobulin
-
Ethical issues in solid organ transplantation: transfusion-free transplantation in Jehovah's witness patients. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-07 Rick Selby, Taylor Selby-Medical, Michael Richman
Jehovah's Witnesses do not accept transfusion of major allogeneic blood fractions. Successful solid organ transplantation is challenging for Jehovah's Witnesses when anemia, coagulation disturbances, and difficult technical aspects co-exist, and key blood bank resources cannot be utilized. Organ availability for transplantation is limited and demand exceeds supply for all organ types. Historically
-
Molecular profiling in the management of hepatocellular carcinoma. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-04 Nadine Soliman, Ashish Saharia, Maen Abdelrahim, Ashton A Connor
The purpose of this review is to both summarize the current knowledge of hepatocellular carcinoma molecular biology and to suggest a framework in which to prospectively translate this knowledge into patient care. This is timely as recent guidelines recommend increased use of these technologies to advance personalized liver cancer care.
-
Hemodynamic monitoring in liver transplantation 'the hemodynamic system'. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-01 Sherif Kandil, Ashraf Sedra
The purpose of this article is to provide a comprehensive review of hemodynamic monitoring in liver transplantation.
-
Pushing the limits of treatment for hepatocellular carcinoma. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-01 Michelle Jones-Pauley, David W Victor, Sudha Kodali
We review existing and newer strategies for treatment and surveillance of hepatocellular carcinoma (HCC) both pre and postliver transplantation.
-
Emerging phenotypes in kidney transplant rejection. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-12-01 Michael Mengel, Benjamin A Adam
This review focuses on more recently emerging rejection phenotypes in the context of time post transplantation and the resulting differential diagnostic challenges. It also discusses how novel ancillary diagnostic tools can potentially increase the accuracy of biopsy-based rejection diagnosis.
-
Transplantation for colorectal liver metastasis. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-24 Pål-Dag Line, Svein Dueland
Liver transplantation has emerged as a possible treatment for selected patients with nonresectable colorectal liver metastasis, but controversy still exists regarding optimal selection criteria and acceptable outcomes.
-
Cardiac evaluation of the liver transplant candidate. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-24 Stephen Possick, Vandana Khungar, Ranjit Deshpande
This review aims to summarize recent changes in the cardiac evaluation of adult liver transplant candidates. Over the last several years, there have been significant advances in the use of coronary computed tomography angiography (CCTA) with and without fractional flow reserve (FFR) and increasingly widespread availability of coronary calcium scoring for risk stratification for obstructive coronary
-
Regulatory dendritic cell therapy in organ transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-23 Yannis Hadjiyannis, Angus W Thomson
Regulatory dendritic cells (DCregs; also 'tolerogenic DCs'), innate immune cells that regulate the alloimmune response, are a novel cellular therapy for organ transplantation. Preliminary results from early-phase clinical trials in live donor kidney and liver transplantation are promising. This follows many years of research elucidating mechanisms of action and utility of DCregs. Herein, we review
-
Controlling infections in hospitalized pretransplant candidates. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-15 Marian G Lacy, Evgenii Filippov, Saman Nematollahi
Infections in hospitalized patients awaiting solid organ transplantation can pose complicated diagnostic and therapeutic challenges. Goals of management include stabilizing the patient, treating or controlling infections, and decreasing the risk of reactivation of infection after transplant.
-
Optimizing cardiac status in the preliver transplant candidate. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-14 Maxine W Stachel, Eugene C DePasquale
Liver transplant is a widely accepted therapy for end-stage liver disease. With advances in our understanding of transplant, candidates are increasingly older with more cardiac comorbidities. Cardiovascular disease also represents a leading cause of morbidity and mortality posttransplant.
-
Enhanced recovery after surgery for liver transplantation: a review of recent literature. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-11-09 Cara E Crouch, Erin Stewart, Adrian Hendrickse
This review was created to highlight important articles from the past year related to the evolving field of enhanced recovery after surgery (ERAS) in liver transplantation that are relevant to the transplant anesthesiologist.
-
Innovative surgical techniques in the intestine and multivisceral transplant. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-31 Phillipe Abreu,Joao Manzi,Rodrigo Vianna
PURPOSE OF REVIEW This timely review delves into the evolution of multivisceral transplantation (MVT) over the past six decades underscoring how advancements in surgical techniques and immunosuppression have driven transformation, to provide insight into the historical development of MVT, shedding light on its journey from experimentation to a valuable clinical approach. RECENT FINDINGS The review
-
Treating rare tumors with liver transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-19 Andrew Melehy, Vatche Agopian
The success of liver transplantation (LT) in treating unresectable hepatocellular carcinoma (HCC) has resulted in interest in LT for other oncologic conditions. Here, we discuss the role of LT for rare oncologic indications including metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), hepatic epitheliod hemangioendothelioma (HEHE), fibrolamellar hepatocellular carcinoma (FLC), and hepatic
-
Optimizing the pediatric transplant candidate. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-13 James E Squires, Vikram K Raghu, George V Mazariegos
Advances in pediatric transplant parallel those in adult populations; however, there remain critical unique considerations and differences that require specialized knowledge and a specific skill set to optimize care afforded to the pediatric transplant candidate. We introduce general themes regarding optimization of the transplant candidate that are unique to children.
-
Current opinion: advances in machine perfusion and preservation of vascularized composite allografts - will time still matter? Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-13 Tessa E Muss, Amanda H Loftin, Byoung Chol Oh, Gerald Brandacher
A major hurdle hindering more widespread application of reconstructive transplantation is the very limited cold ischemia time (CIT) of vascularized composite allografts (VCAs). In this review, we discuss cutting edge machine perfusion protocols and preservation strategies to overcome this limitation.
-
Defining chronic rejection in vascularized composite allografts - do we have reliable surrogates to look for? Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-10 Jean Kanitakis
Chronic rejection (CR) is a major threat in the field of vascularized composite tissue allografts (VCAs) as it causes graft dysfunction and usually graft loss. Unfortunately, knowledge of CR in VCA is incomplete because of the limited number of VCA recipients, the heterogeneous nature of VCAs and the short follow-up.
-
Novel cell-based strategies for immunomodulation in vascularized composite allotransplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-07 Maria Siemionow, Yalcin Kulahci, Fatih Zor
Vascularized composite allotransplantation (VCA) has become a clinical reality in the past two decades. However, its routine clinical applications are limited by the risk of acute rejection, and the side effects of the lifelong immunosuppression. Therefore, there is a need for new protocols to induce tolerance and extend VCA survival. Cell- based therapies have emerged as an attractive strategy for
-
Transplant tourism - a missed opportunity. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-10-04 Hadar Merhav
To explore the resurgence of transplant tourism (TT) despite the recent reiteration of the Declaration of Istanbul (DoI) in 2018. As demand grows exponentially and supply remains static, novel approaches to bridging the gap should be explored.
-
Improving liver transplant outcomes with transplant-omics and network biology. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-29 Joseph Scarpa
PURPOSE OF REVIEW Molecular omics data is increasingly ubiquitous throughout medicine. In organ transplantation, recent large-scale research efforts are generating the 'transplant-ome' - the entire set of molecular omics data, including the genome, transcriptome, proteome, and metabolome. Importantly, early studies in anesthesiology have demonstrated how perioperative interventions alter molecular
-
What is needed to ensure long-term sustainability for the field of vascularized composite allotransplantation? Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-29 Yoshiko Toyoda, L Scott Levin
The field of vascularized composite allotransplantation (VCA) has demonstrated remarkable advances since its inception with some excellent long-term results in a variety of graft types. However, unlike solid organ transplantation, it has yet to become mainstream. We therefore discuss strategies on ensuring long-term sustainability by addressing continued clinical developments of VCA to improve the
-
Expanding indications for urogenital transplantation: congenital and oncologic defects, and gender affirmation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-26 Christopher D Lopez,Alisa O Girard,Richard J Redett
PURPOSE OF REVIEW Penile transplantation has become an emerging option for patients with severe genital defects. Only transplantation restores anatomy, sexual, and reproductive function of the penis. However, penile transplantation comes with important technical, psychosocial, ethical, and surgical challenges that must be considered for successful implementation. Indications for penile transplantation
-
Respiratory viral infections including COVID-19 in solid organ transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-26 Carson K L Lo,Deepali Kumar
PURPOSE OF REVIEW Respiratory viral infections are prevalent and contribute to significant morbidity and mortality among solid organ transplant (SOT) recipients. We review updates from literature on respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the SOT recipient. RECENT FINDINGS With the wider availability and use of molecular diagnostic tests, our
-
The history of ethical principles in liver transplant organ allocation in the united states: how historical and proposed allocations system fare in balancing utility vs. urgency and justice vs. pragmatism. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-22 Aaron Ahearn
The United States (US) liver transplant community is processing changes to the allocation system and developing a new proposal that will result in even greater change. This review evaluates the ethical implications of these decisions, focusing on two sets of competing ethical principles (Urgency vs. Utility and Justice vs. Pragmatism).
-
A review of transplant infectious diseases and pediatric transplant infectious diseases curriculum. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-22 Megan K Morales, Lara Danziger-Isakov, Saman Nematollahi
As the volume and complexity of solid organ and hematopoietic stem cell transplantation continue to see rapid growth, the training of a specialized transplant infectious diseases physician workforce is of increasing interest and importance. This review provides an overview of the evolution of transplant infectious diseases training programs, essential elements of training, as well as future needs.
-
Pain management for liver transplant recipients. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-20 Simrat Kaur,Patrick Henthorn,Adrian Hendrickse
PURPOSE OF REVIEW Liver transplant recipients pose several pain management challenges. Altered hepatic drug metabolism and clearance in end-stage liver disease patients complicates the use of certain medications, while existing coagulopathy and thrombocytopenia can limit the use of regional anesthetic techniques. Largely due to a high prevalence of substance use disorders, these patients have increased
-
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-19 Kofi B Vandyck, Walter Rusin, Samhati Mondal, Kenichi A Tanaka
Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).
-
Living liver donor pain management. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-09-08 Ryung A Kang, Justin Sangwook Ko
Optimal pain control in living liver donors undergoing hepatectomy is strongly recommended considering their unique status as healthy individuals willingly undergoing surgery for the benefit of the recipient. This review aims to examine and evaluate different strategies aimed at ensuring effective postoperative pain management in living liver donors.
-
How to measure human leukocyte antigen-specific B cells. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-18 Delphine Kervella, Alba Torija, Jose M Zúñiga, Oriol Bestard
The implementation of highly sensitive immune assays measuring anti-human leukocyte antigen (HLA) antibodies has modified alloimmune risk stratification and diagnosis of rejection. Nonetheless, anti-HLA antibodies represent the downstream effector mechanism of the B-cell response. Better characterizing the cellular components of the humoral immune response (including memory B cells (mBCs) and long-lived
-
Challenges with the current United Network for Organ Sharing heart allocation system. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-15 Timothy A Gong, Shelley A Hall
The revised United States heart organ allocation system was launched in October 2018. In this review, we summarize this United Network for Organ Sharing (UNOS) policy and describe intended and unintended consequences.
-
Role of complement in humoral immunity. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-13 Manuel Alfredo Podestà,Nicholas Chun
PURPOSE OF REVIEW Antibody-mediated rejection (AMR) after solid organ transplantation remains an unsolved problem and leads to poor early and late patient outcomes. The complement system is a well recognized pathogenic mediator of AMR. Herein, we review the known molecular mechanisms of disease and results from ongoing clinical testing of complement inhibitors after solid organ transplant. RECENT FINDINGS
-
Dual organ transplantation: when heart alone is not enough. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-13 Abdulelah Nuqali,Lavanya Bellumkonda
PURPOSE OF REVIEW The number of dual organ transplantations (DOT) are steadily increasing over the past few years. This is both a reflection of increasing complexity and advanced disease process in the patients and greater transplant center experience with performing dual organ transplants. Due to lack of standardization of the process, there remains significant center-based variability in patient
-
Management of the sensitized heart transplant candidate. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-09 Michelle M Kittleson
For sensitized heart transplant candidates who have antibodies to human leukocyte antigens (HLA), finding a suitable donor can be challenging and can lead to adverse waitlist outcomes. In recent years, the number of sensitized patients awaiting heart transplantation has increased likely due to the use of durable and mechanical circulatory support as well as increasing number of candidates with underlying
-
Acute complication posttransplant: primary allograft dysfunction. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-09 Darshan H Brahmbhatt, David Blitzer, Filio Billia, Hannah Copeland
Heart transplant is the gold standard treatment for patients with end-stage heart failure, improving both quality of life and survival. Despite advances in donor and recipient management, primary graft dysfunction (PGD) remains the most common cause of morbidity and mortality in the early posttransplant period. This review summarizes recent discoveries in the underlying pathophysiology, risk prediction
-
Histologic and molecular features of antibody-mediated rejection. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-07-31 Ivy A Rosales, Rex Neal Smith, Robert B Colvin
This review aims to summarize the highlights from recent research that involved pathological and molecular analysis of kidney allografts.
-
Mind the gaps: reframing patient selection and organ allocation in liver transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-08-01 Joseph DiNorcia
-
Medical intestinal rehabilitation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-23 Maria C Segovia
Medical intestinal rehabilitation is a part of the very complex management of patients with intestinal failure. The goal is to achieve enteral autonomy and minimize need for parenteral nutrition and hydration. In this manuscript, we will review the strategies to achieve this goal with dietary optimization and pharmacologic interventions.
-
Stroke and kidney transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-23 Adrian P Abreo, Deepak Kataria, Chaitanya Amrutkar, Ayush Singh, Millie Samaniego, Neeraj Singh
This review will focus on the epidemiological data, risk factors, and management of stroke before and after kidney transplant. Stroke is highly prevalent in waitlisted patients as well as kidney transplant recipients and is associated with impaired transplant outcomes. Multiple traditional, nontraditional, and transplanted risk factors increase the risk of stroke.
-
Equity in liver transplantation: are we any closer? Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-20 Moronke Ogundolie, Norine Chan, Lisa M McElroy
As policies governing liver transplantation (LT) continue to change and influence clinical practice, it is important to monitor trends in equitable access and outcomes amongst patients. The purpose of this review is to closely examine recent advances and findings in health equity research in LT over the last 2 years; specifically evaluating inequities at the different stages of LT (referral, evaluation
-
Liver transplantation for unresectable colorectal liver metastasis. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-20 Mariana Chávez-Villa, Luis I Ruffolo, Roberto Hernandez-Alejandro
To summarize the current state of liver transplantation (LT) for unresectable colorectal liver metastases (uCRLM), and to address future directions.
-
Optimizing liver transplant prioritization for hepatocellular carcinoma through risk stratification. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-20 Joshua Norman, Neil Mehta, Allison Kwong
In the United States, candidates with hepatocellular carcinoma (HCC) meeting standardized qualifying criteria receive similar priority on the liver transplant waiting list through Model for End-Stage Liver Disease exception points, without consideration of the dropout risk or relative expected benefit from liver transplantation. A more nuanced allocation scheme for HCC is needed to better represent
-
Pediatric intestine and multivisceral transplant. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-12 Mohamed Maklad, George Mazariegos, Armando Ganoza
Intestinal and multivisceral transplantation (ITx, MVTx) is the cornerstone in treatment of irreversible intestinal failure (IF) and complications related to parenteral nutrition. This review aims to highlight the unique aspects of the subject in pediatrics.
-
The sex disparity in liver transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-09 Rachel Hogen,Matthew Hunter Witt,Kiran Dhanireddy
PURPOSE OF THE REVIEW This review describes the sex disparity in liver transplantation (LT) and explains its underlying causes. RECENT FINDINGS There is a small but persistent sex disparity in transplant rate and waitlist mortality that disappears once women are listed as Status 1. Allocation systems that could replace the Model for End Stage Liver Disease (MELD)-Na with scores less reliant on serum
-
Immunosuppression in HIV-positive kidney transplant recipients. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-05-24 Bogdan Marian Sorohan, Gener Ismail, Nicolae Leca
The purpose of this review is to provide the current state of immunosuppression therapy in kidney transplant recipients (KTR) with HIV and to discuss practical dilemmas to better understand and manage these patients.
-
HLA-DQ antibodies in alloimmunity, what makes them different? Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-05-24 Maria Meneghini, Anat R Tambur
De novo HLA-DQ antibodies are the most frequently observed after solid-organ allotransplantation; and are associated with the worse adverse graft outcomes compared with all other HLA antibodies. However, the biological explanation for this observation is not yet known. Herein, we examine unique characteristics of alloimmunity directed specifically against HLA-DQ molecules.
-
Overview of pregnancy in solid-organ transplantation. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-05-23 Priya Yenebere, Mohankumar Doraiswamy, Aijaz Gundroo
Pregnancy in solid organ transplantation (SOT) is a very complex part of transplant medicine wherein there is scarce information available in the literature. Solid organ transplant recipients often have comorbidities, such as hypertension and diabetes, which add additional risk to a pregnancy.
-
Postoperative surgical complications after pediatric kidney transplantation in low weight recipients (<15 kg): a systematic review. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-05-22 Thomas Prudhomme, Benoit Mesnard, Olivier Abbo, Beatriz Banuelos, Angelo Territo
Kidney transplantation in low-weight recipients (<15 kg) is a challenging surgery with special characteristics. We proposed to perform a systematic review to determine the postoperative complication rate and the type of complications after kidney transplantation in low-weight recipients (<15 kg). The secondary objectives were to determine graft survival, functional outcomes, and patient survival after
-
A pivot from donation alone to donation and transplantation, combined. Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-06-01 John L R Forsythe
-
Social and biologic determinants in lung transplant allocation Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-04-18 Kara Calhoun, Joshua Smith, Alice L. Gray
Purpose of review Lung transplant is a life-saving intervention for many with end-stage lung disease. As usable donor lungs are a limited resource and the risk of death on the waitlist is not uniform among candidates, organ allocation must consider many variables in order to be equitable. Recent findings The lung allocation score (LAS) system, implemented in 2005, accounted for disease severity,
-
Primary graft dysfunction after lung transplantation Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-04-13 Mallory L. Hunt, Edward Cantu
Purpose of review Primary graft dysfunction (PGD) is a clinical syndrome occurring within the first 72 h after lung transplantation and is characterized clinically by progressive hypoxemia and radiographically by patchy alveolar infiltrates. Resulting from ischemia-reperfusion injury, PGD represents a complex interplay between donor and recipient immunologic factors, as well as acute inflammation
-
Pediatric intestinal rehabilitation Curr. Opin. Organ Transplant. (IF 2.2) Pub Date : 2023-04-12 Hironori Kudo, Motoshi Wada
Purpose of review The intestinal rehabilitation program (IRP) is a comprehensive treatment strategy that employs various approaches implemented by multidisciplinary teams to treat intestinal failure in children. This program has shown promising results, such as reducing complications and improving prognosis and quality of life (QOL). In this review, we discuss the current status of this program and