-
Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-13 Lidan Zhang, Ge Kuang, Xia Gong, Rui Huang, Zizuo Zhao, Yan Li, Jingyuan Wan, Bin Wang
Piperine, the major active substance in black pepper, has been shown to have anti-inflammatory and antioxidant effects in several ischemic diseases. However, the role of piperine in hepatic ischemia/reperfusion injury (HIRI) and its underlying mechanisms remain unclear. In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion
-
An autophagy-associated diagnostic signature based on peripheral blood for antibody-mediated rejection in renal transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-06 Yue Xu, Yuxuan Wang, Di Zhang, Hao Zhang, Yicun Wang, Wei Wang, Xiaopeng Hu
Antibody-mediated rejection (ABMR) emerged as a major cause of graft loss in renal transplantation. Needle biopsy is the gold standard for diagnosis of ABMR in renal allografts. Thus, noninvasive diagnosis methods of ABMR with high accuracy are urgently needed to prevent unnecessary biopsies. We collected peripheral blood transcriptome data from two independent renal transplantation cohorts with patients
-
The hybrid CL-SP-D molecule has the potential to regulate xenogeneic rejection by human neutrophils more efficiently than CD47 Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-06 Keigo Iemitsu, Rieko Sakai, Akira Maeda, Katarzyna Gadomuska, Shuhei Kogata, Daiki Yasufuku, Jun Matsui, Kazunori Masahata, Masafumi Kamiyama, Hiroshi Eguchi, Soichi Matsumura, Yoichi Kakuta, Hiroshi Nagashima, Hiroomi Okuyama, Shuji Miyagawa
Innate immunity plays a vital role in xenotransplantation. A CD47 molecule, binding to the SIRPα expressed on monocyte/macrophage cells, can suppress cytotoxicity. Particularly, the SIRPα contains ITIM, which delivers a negative signal. Our previous study demonstrated that the binding between CL-P1 and surfactant protein-D hybrid (CL-SP-D) with SIRPα regulates macrophages' phagocytic activity. In this
-
Risks of infection and severity of coronavirus disease 2019 in kidney transplant recipients: A single-center cohort study Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-06 Kuniaki Inoue, Shunta Hori, Mitsuru Tomizawa, Tatsuo Yoneda, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Kiyohide Fujimoto
The severity of coronavirus disease 2019 (COVID-19) is known to be high in kidney transplant recipients; however, the risk factors for COVID-19 infection in these patients has not been studied extensively. Therefore, we explored the predictors of COVID-19 infection and severity in kidney transplant recipients in Japan. This study included kidney transplant recipients who were regularly followed-up
-
Identification of Cbx6 as a potential biomarker in renal ischemia/reperfusion injury Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-05 Ziwen Pan, Sheng Chang, Song Chen, Zhiyu Zou, Yibo Hou, Zhishui Chen, Weijie Zhang
Renal ischemia/reperfusion injury (RIRI) is an inevitable consequence of kidney transplantation and has a negative impact on both short-term and long-term graft survival. The identification of key markers in RIRI to improve the prognosis of patients would be highly advantageous. Gene expression profile data of GSE27274 were obtained from the Gene Expression Omnibus database. Differentially expressed
-
Human amniotic mesenchymal stem cells inhibit immune rejection injury from allogeneic mouse heart transplantation: A preliminary study on the microRNA expression Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-05 Haoyuan Wang, Xin Mao, Yue Zhong, Xu Zhao, Chuntian Li, Jun Jiang, Zheng Hong, Nuoxin Wang, Feng Wang
Mesenchymal stem cell therapy is a new treatment for immune rejection in heart transplantation. The aim of this paper is to investigate the effect of human amniotic mesenchymal stem cells (hAMSCs) on alleviating immune rejection of allogeneic heart transplantation in mice and its possible underlying mechanism. We injected hAMSCs into cervical ectopic heart transplantation model mice via tail vein to
-
Impact of COVID-19 vaccination on clinical outcomes in kidney transplant patients Transpl. Immunol. (IF 1.5) Pub Date : 2024-03-05 Ana Flávia Vieira Ferreira de Assis, Letícia de Oliveira Santos, Mariana Almeida Botelho, Evaldo Nascimento, Raquel A. Fabreti-Oliveira
The global health crisis caused by the COVID-19 pandemic has resulted in severe mortality and morbidity. Immunosuppressed patients, such as kidney transplant recipients, are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The aim of this cohort study was to evaluate the impact of COVID-19 vaccination on clinical outcomes in patients with kidney transplants
-
Successful treatment of a kidney transplant patient with severe novel coronavirus pneumonia: A case report Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-28 Shuang Li, Tao Feng, Xingliang Hao, Yingying Wang, Jian Zhang
The high infection rate and mortality associated with novel coronavirus infections have attracted worldwide attention; however, the impact of the novel coronavirus on patients with a history of renal transplantation has not been investigated thoroughly. This report presents a patient with SARS-CoV-2 pneumonia following kidney transplantation. The patient developed acute respiratory distress syndrome
-
Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-23 Dario Costa, Antonietta Picascia, Vincenzo Grimaldi, Cristiano Amarelli, Andrea Petraio, Anna Levi, Mario Di Donato, Anna Virginia Adriana Pirozzi, Carmela Fiorito, Giusi Moccia, Aurora Gallo, Mariagrazia Strozziero, Claudio Marra, Marisa De Feo, Francesco Cacciatore, Ciro Maiello, Claudio Napoli
Although there are different data supporting benefits of HLA matching in kidney transplantation, its role in heart transplantation is still unclear. HLA mismatch (MM) between donor and recipient can lead to the development of donor-specific antibodies (DSA) which produces negative events on the outcome of heart transplantation. Moreover, DSAs are involved in the development of antibody-mediated rejection
-
Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-23 Abdullah, Indrajeet Momin, Anupma Kaul, Dharmendra Bhadauria, Narayan Prasad, Manas Behera, Manas Patel, Ravi Kushwaha, Monika Yachha, Aneesh Srivastava
The incidence of post-transplant diabetes mellitus (PTDM) ranges from 2.5% to 20% in kidney transplant recipients. Diabetic retinopathy (DR), diabetic kidney disease (DKD), and distal symmetric polyneuropathy (DSPN) are the microvascular complications frequently seen in both type 1 and 2 diabetes mellitus (DM). However, the data regarding these complications in patients with PTDM is lacking. A retrospective
-
Long-term remission of infantile Takayasu arteritis associated with germline CBL syndrome after allogeneic hematopoietic stem cell transplantation: A case report and literature review Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-22 Elizabeth Munoz-Osores, Mervin Piñones, Francisco Barriga, María Angélica Wietstruck, Guillermo Pérez-Mateluna, Cecilia Mellado, Mariana Aracena, Rodrigo Parra, Cristián García, Arturo Borzutzky
Takayasu arteritis (TA) is a large-vessel vasculitis that rarely presents in infancy. Casitas B-lineage lymphoma (CBL) syndrome is a rare genetic disorder due to heterozygous gene germline pathogenic variants that is characterized by a predisposition to develop juvenile myelomonocytic leukemia (JMML). Vasculitis, including TA, has been reported in several patients. Herein, we describe a patient with
-
Conversion from twice-daily everolimus to once-daily sirolimus in long-term stable liver transplant recipients Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-21 Jérôme Dumortier, Olivier Boillot
After organ transplantation, strategies for simplifying the therapeutic regimen may improve adherence and prevent acute organ rejection and/or late graft loss. The present study aimed to evaluate the safety and efficacy of conversion from everolimus (EVR) twice daily to sirolimus (SIR) once daily in a large cohort of liver transplantation (LT) patients. We included 108 LT patients with at least 12 months
-
Retrospective analysis on incidence and risk factors of post-transplant diabetes mellitus after lung transplantation and its association with clinical outcomes Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-09 Wenwen Du, Xiaoxing Wang, Dan Zhang, Xianbo Zuo
Post-transplant diabetes mellitus (PTDM) is a common complication after transplantation. We aim to explore potential risk factors of PTDM and its association with outcomes after lung transplantation (LTx). A retrospective study was conducted in 100 patients who underwent LTx at our institution from 2017 to 2021. Patients' information was collected, and genotyping for single nucleotide polymorphisms
-
H2S alleviates renal ischemia and reperfusion injury by suppressing ERS-induced autophagy Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-09 Sujuan Feng, Jiawei Ji, Han Li, Xiaodong Zhang
Ischemia/reperfusion injury (IRI) can lead to acute kidney injury and result in high disability and mortality rates. Cystathionine γ-lyase (CSE)-produced hydrogen sulfide (HS) has been confirmed to play a protective role in renal IRI. While autophagy is involved in renal IRI, its role in the regulation by endoplasmic reticulum stress (ERS) has not been considered. Our study explored the role of CSE/HS
-
Protective effects and mechanisms of dapagliflozin on renal ischemia/reperfusion injury Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-05 Na Li
Renal diseases have a significant negative impact on human health and the quality of life. Renal ischemia/reperfusion (I/R) injury is considered as one of the leading causes of renal dysfunction and tissue damage. Oxidative stress and inflammation are responsible for cellular apoptosis playing critical roles in renal I/R injury. Recent studies suggested that dapagliflozin—a medication used to treat
-
Three-year outcomes of de novo tacrolimus extended-release tablets (LCPT) compared to twice-daily tacrolimus in adult heart transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-05 Amit Alam, Johanna S. van Zyl, Raksha Patel, Aayla K. Jamil, Joost Felius, Sandra A. Carey, Robert L. Gottlieb, Cesar Y. Guerrero-Miranda, Parag Kale, Shelley A. Hall, Teena Sam
Extended-release tacrolimus for prophylaxis of allograft rejection in heart transplant (HT) recipients is currently not FDA-approved. One such extended-release formulation of tacrolimus known as LCPT allows once-daily dosing and improves bioavailability compared to immediate-release (IR-) tacrolimus. We compared long-term efficacy and safety of LCPT to IR-tacrolimus applied de novo in adult OHT recipients
-
Hemophagocytic lymphohistiocytosis after solid organ transplantation: A challenge for clinicians Transpl. Immunol. (IF 1.5) Pub Date : 2024-02-01 Shanshan Xu, Kang He
Hemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory disorder with a high mortality rate and a wide range of symptoms. Solid organ transplantation, which provides patients with a unique immunosuppressive state, is a less common predisposing factor for HLH. HLH after solid organ transplantation (HLH-SOT) is very rare and fatal. It is hard to diagnose and treat and extremely understudied.
-
Efficacy and Safety in Early application of Ruxolinitib for high-risk: Acute lymphoblastic leukemia to prevent GVHD and recurrence after allogeneic hematopoietic stem cell transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-30 Qian Cheng, Yishu Tang, Feiyang Liu, Xin Li, Dan Fang
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been identified as the potentially curative treatment for high-risk acute lymphoblastic leukemia (ALL) in adult patients. However, relapse of the disease and/or development of graft-versus-host disease (GVHD) remain to be the most common barriers for successful allo-HSCT. Preclinical studies showed that ruxolitinib, a Janus tyrosine
-
Interleukin-10 GCC/GCC haplotype is associated high risk of acute GVHD in patients undergoing allogeneic HSCT in the southern of Brazil Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-28 Mariela Granero Farias, Camila Andrade dos Santos, Alessandra Aparecida Paz, Liane Esteves Daudt
Hematopoietic Stem Cell Transplant (HSCT) is currently an important curative treatment for many patients with malignant and non-malignant diseases. Graft versus host disease (GVHD) represents a major complication in allogeneic HSCT recipients. Several polymorphisms in cytokine genes have recently been investigated as candidates for risk factors for acute-GVHD (aGVHD) in allogeneic hematopoietic stem
-
-
Nephrotic proteinuria and hematuria with newly diagnosed IgA nephropathy after liver transplant: A case report Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-23 Tingli Wang, Honghong Ren, Dan Yin, Hongyu Qiu
IgA nephropathy is a renal lesion in patients with end-stage liver disease, called hepatic IgA nephropathy. The common manifestation of hepatic IgA nephropathy is microscopic hematuria. Sirolimus, often used to prevent organ rejection, has been reported to induce proteinuria after organ transplantation. But few cases of nephrotic proteinuria and hematuria are reported. In this case, a 45-year-old male
-
Exploration of the shared gene signatures and biological mechanisms between ischemia-reperfusion injury and antibody-mediated rejection in renal transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-22 Shan Jiang, Hua Su
Antibody-mediated rejection (ABMR) plays a crucial role in graft loss during allogeneic renal transplantation. In renal transplantation, ischemia-reperfusion injury (IRI) is unavoidable, serves as a major contributor to acute rejection, and is linked to graft loss. However, the mechanisms underlying IRI and ABMR are unclear. Therefore, this study aimed to investigate the shared genetic characteristics
-
Probiotics, gut microbiome, and cardiovascular diseases: An update Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-21 Laura Dosh, Maya Ghazi, Karim Haddad, Jad El Masri, Jihad Hawi, Angelo Leone, Charbel Basset, Alice Gerges Geagea, Rosalyn Jurjus, Abdo Jurjus
Cardiovascular diseases (CVD) are one of the most challenging diseases and many factors have been demonstrated to affect their pathogenesis. One of the major factors that affect CVDs, especially atherosclerosis, is the gut microbiota (GM). Genetics play a key role in linking CVDs with GM, in addition to some environmental factors which can be either beneficial or harmful. The interplay between GM and
-
Retraction notice to “Inhibition of miR-495-3p ameliorated sevoflurane induced damage through BDNF/ERK/CREB signaling pathways in HT22 cells” [Transplant Immunology, Volume75, December 2022, 101708] Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-19 Xiaomei Chen, Chongyi Li, Rui Zeng, Ling Qiu, Jianhang Huang, Ning Wang, Xia Ren, Xingwu Lin
Abstract not available
-
Tacrolimus impairs airway mucociliary clearance of rats Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-09 Maristela Prado e Silva, Sônia de Fátima Soto, Francine Maria de Almeida, Aristides Tadeu Correia, Paulo Manuel Pêgo-Fernandes, Rogerio Pazetti
Objectives Tacrolimus (TAC) is the most widely used immunosuppressive agent after lung transplantation. Considering that the ciliary beat frequency (CBF) mainly depends on the cytoplasmic calcium concentration and that TAC can affect this due to its binding with the intracellular immunophilin FKBP12, we hypothesized that TAC could also impair the airway mucociliary clearance of rats. Methods Sixty
-
Renal transplantation for infantile and juvenile cystinosis: Two case report and review of the literature Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-14 Karen El Ghoul, Dany Akiki, Nagi Nawfal, Maroun Abou Jaoude
Cystinosis is a rare autosomal recessive lysosomal storage disorder characterized by cystine buildup in various tissues, including the kidneys. Renal involvement is the primary manifestation, leading to end-stage renal disease (ESRD) if left untreated. Kidney transplantation (KT) in patients with cystinosis has significantly improved their prognosis for the disease outcome. Detailed reports on preoperative
-
The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-11 Ivana Dedinská, Patrícia Kleinová, Katarína Macháleková, Karol Graňák, Matej Vnučák, Monika Beliančinová
White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation. In a prospective analysis ( = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month
-
Upregulation of IDO gene expression reduces the immunogenicity of epidermal cells and strengthens the immune protection of epidermal cells during transplantation treatment of wounds Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-11 Kun Zhang, Xinzhu Liu, Peng Luo, Zhisheng Li, Hongqing Zhao, Dawei Li, Zhaoxing Liu, Bohan Zhang, Chuanan Shen
Background Epidermal cell transplantation is a feasible treatment option for large wounds; however, sources of autologous epidermal cells are often limited. Allogeneic epidermal cells can be cultured conveniently; however, related immune rejection needs to be addressed. Herein, we hypothesized that the immunogenicity of epidermal cells with high indoleamine 2,3-dioxygenase (IDO) expression may be reduced
-
Investigating the effect of pre-transplant thrombocytopenia and anemia on the engraftment and long-term survival in multiple myeloma patients Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-08 Dariush Kadkhoda, Maryam Nikoonezhad, Hossein Bonakchi, Mahshid Mehdizadeh, Abbas Hajifathali, Ahmad Reza Baghestani, Leila Jabarinanva, Ali Akbar Khadem Maboudi
Background Autologous stem cell transplantation (ASCT) following high-dose melphalan is the standard treatment for Multiple Myeloma (MM). Despite new treatments, further investigation is needed to identify prognostic factors of ASCT. This study evaluated the impact of thrombocytopenia and anemia on the engraftment of MM patients after ASCT. Materials and methods This retrospective study involved 123
-
Allogeneic hematopoietic stem cell transplantation: A single-center experience, 2017 to 2021 Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-08 Patrícia Cristina Lopes da Silva, Guilherme Campos Muzzi, Maressa Ribeiro Vilela, Raquel A. Fabreti-Oliveira
Introduction Hematopoietic stem cell transplantation (HSCT) remains a critical treatment for advanced or high-risk hematological malignancies, posing challenges such as finding suitable donors and managing of graft-versus-host disease (GvHD). This study estimates 3-year overall survival in patients who underwent HSCT at our referral service in the state of Minas Gerais, Brazil. Material and methods
-
Conversion from calcineurin inhibitors to belatacept-based immunosuppressive therapy skews terminal proliferation of non-classical monocytes and lowers lymphocyte counts Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-08 O.W. Bredewold, A.M. van Oeveren-Rietdijk, B. Florijn, J.I. Rotmans, J.W. de Fijter, C. van Kooten, A.J. van Zonneveld, H.C. de Boer
Belatacept, a modified form of CTLA-Ig that blocks CD28-mediated co-stimulation of T cells, is an immune-suppressant that can be used as an alternative to calcineurin inhibitors (CNIs). In kidney transplant recipients, belatacept has been associated with improved renal function and reduced cardiovascular toxicity. Monocytes as well as T-lymphocytes play causal roles in the pathophysiology of atherosclerotic
-
The association between activation of the ERK1/2-NF-κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Tong Chen, Shiquan Wu, Ling Feng, Siyu Long, Yu Liu, Caibin Zhang, Wenqian Lu, Yuli Shen, Shanshan Jiang, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zou
Purpose The tissue inhibitor of metalloproteinase 2 (TIMP2), a natural inhibitor of matrix metalloproteinase (MMP), regulates inflammation, fibrosis, and cell proliferation. Chronic renal allograft dysfunction (CRAD) is a primary factor affecting the long-term survival of renal allografts. We assessed whether up-regulation of TIMP2 expression may affect the ERK1/2-NF-κB signaling pathway and CRAD development
-
Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-05 Masatomo Kuno, Hideo Koh, Kentaro Ido, Kazuki Sakatoku, Yosuke Makuuchi, Teruhito Takakuwa, Asao Hirose, Hiroshi Okamura, Mitsutaka Nishimoto, Yasuhiro Nakashima, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae
Background No comparative data have shown significant survival differences between HLA-mismatched unrelated donor (MMUD) transplantation and cord blood (CB) transplantation, each with reduced-intensity/reduced-toxicity conditioning (RIC/RTC). However, advances in graft-versus-host disease (GVHD) prophylaxis might help update current strategies. Methods We retrospectively compared the outcomes of first
-
Effect of GVHD on the gut and intestinal microflora Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-05 Hao Ji, Shuai Feng, Yuan Liu, Yue Cao, HuiQuan Lou, Zengzheng Li
Graft-versus-host disease (GVHD) is one of the most important cause of death in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The gastrointestinal tract is one of the most common sites affected by GVHD. However, there is no gold standard clinical practice for diagnosing gastrointestinal GVHD (GI-GVHD), and it is mainly diagnosed by the patient's clinical symptoms
-
Caffeine and naloxone treated mesenchymal stem cells improve symptoms and reduce inflammation in a mouse model of ulcerative colitis Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-05 Milad Beygi, Jalal Shayegh, Hadi Esmaeili Gouvarchin Ghaleh
Background and objective Ulcerative colitis (UC) causes ulcers in the colon and rectum, leading to abdominal pain, diarrhea, and rectal bleeding, and if left untreated, can lead to serious complications. The therapeutic effects of mesenchymal stem cells (MSCs) on experimental models of UC have been proven. Since the microenvironment around these cells is crucial in maintaining cell proliferation, differentiation
-
Recruiting refugees and migrants as potential hematopoietic stem cell donors to serve patients of comparable ethnicities with rare human leucocyte antigen patterns - The BluStar.NRW project in North Western Germany Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 F.M. Heinemann, C. Baumgart, C. Binder, V. Börger, J.C. Fischer, A. Heinold, C. Jiménez Klingberg, V. Lenz, S. Riebschläger, T. Zeiler, P.A. Horn, L. Kordelas
Currently, approximately 19 million people with a migration background live in Germany. The majority of those descend from regions where the population has a genetically different distribution of HLA antigens when compared to the HLA frequencies usually found in North Western Europe. In case of severe haematological disorders of these individuals, allogeneic stem cell transplantation may be the treatment
-
Neutrophil: Lymphocyte and Platelet: Lymphocyte ratios measured before transplantation and their correlation with new-onset diabetes post-transplantation in renal transplant recipients Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Nguyen Thi Thuy Dung, Pham Vu Thuy, Nguyen Trí Tue, Truong Quy Kien, Nguyen Van Duc, Diem Thi Van, Do Manh Ha, Nguyen Thi Thu Ha, Phan Ba Nghia, Nguyen Trung Kien, Tran Van Hinh, Nguyen Minh Nui, Pham Quoc Toan, Nguyen Duc Loc, Dang Thi Viet Ha, Do Gia Tuyen, Le Viet Thang
Purpose Our goal was to evaluate the neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR) ratios measured before transplantation and their correlation with new-onset diabetes after transplantation (NODAT) in renal transplant recipients. Patients and methods We conducted our study in 324 adult patients consecutively admitted to Military Hospital 103, Ha Noi, Viet Nam, who received kidney allografts
-
Relationships, race/ethnicity, gender, age, and living kidney donation evaluation willingness Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Jonathan Daw, Mary K. Roberts, Zarmeen Salim, Nathaniel D. Porter, Ashton M. Verdery, Selena E. Ortiz
Racial/ethnic and gender disparities in living donor kidney transplantation are large and persistent but incompletely explained. One previously unexplored potential contributor to these disparities is differential willingness to donate to recipients in specific relationships such as children, parents, and friends. We collected and analyzed data from an online sample featuring an experimental vignette
-
Influence of HLA-A, [sbnd]B, and -DRB1 genes and panel-reactive antibodies on the waitlist time for kidney transplantation in the state of Sao Paulo-Brazil Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Camila Ravazzi-Gauch, Ludimila Leite Marzochi, Miklos Maximiliano Bajay, Marizete Peixoto Medeiros, Heloisa Cristina Caldas, Mario Abbud-Filho
Brazil ranks second in the absolute number of transplants. However, the supply remains insufficient to meet the demands, resulting in a lengthy waitlist. This study aimed to analyze whether the frequency of human leukocyte antigen (HLA) and the value of calculated panel reactive antibody (cPRA) would influence the waiting time for kidney transplantation. The HLA-A, B, and -DRB1 frequencies and the
-
Validation of the kidney donor profile index (KDPI) for deceased donor kidney transplants in China Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Bo Yu, Yiting Liu, Tianyu Wang, Yalong Zhang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Jiangqiao Zhou, Tao Qiu
Background The kidney donor profile index (KDPI) evaluates kidney donor's age, height, weight, ethnicity, cause of death, high blood pressure, diabetes, exposure to hepatitis C and estimated glomerular filtration (eGFR). Kidneys with lower KDPI scores are expected to function longer that those with higher KPDI values. The applicability of KDPI score in Chinese kidney transplant donation has not yet
-
Identification and characterization of two immune-related subtypes in human chronic kidney disease Transpl. Immunol. (IF 1.5) Pub Date : 2024-01-04 Xiangdong Fang, Yanxia Chen, Yan Chen, Minzi Qiu, Jinjing Huang, Ben Ke
Background Immune response plays a vital role in the initiation and development of chronic kidney disease (CKD). Detailed mechanisms and specific immune-related biomarkers of CKD need further clarification. We aimed to identify and characterize immune-related infiltrates that are implicated in the CKD development using a bioinformatics method. Methods The expression profiles of GSE66494 dataset were
-
sVEGF-R1 in acute non-infectious toxicity syndromes after pediatric allogeneic hematopoietic stem cell transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-12-19 Denise Elbæk Horan, Katrine Kielsen, Sarah Wegener Weischendorff, Maria Ebbesen Sørum, Marte B. Kammersgaard, Marianne Ifversen, Claus Nielsen, Lars P. Ryder, Pär I. Johansson, Klaus Müller
Background Allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute non-infectious toxicities, including sinusoidal obstruction syndrome (SOS), engraftment syndrome (ES) and capillary leak syndrome (CLS) among others. These complications are thought to be driven by a dysfunctional vascular endothelium, but the pathophysiological mechanisms remain incompletely understood, and
-
Microvascular activation and exocytosis after exposure to the serum from mismatched recipients by using donor microvascular cultures Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-25 Qiang Sebastian Shi, Xin Jiang, Ming Li, Jun Fang, Zhiqiang Fu, Shengyi Zhu, Chengyu Wu, Qianghe Meng, Tun Jie, Medhat Askar
Background Microvascular injury resulting from activation and exocytosis are early signs of tissue damage caused by allografting. However, humoral anti-graft reactions are not easily detectable in transplant biopsies. The aim of this study was to establish a bioassay to recapitulate this process in a prospective approach. Methods The study was executed by using our previously established protocol to
-
Indoleamine 2, 3-dioxygenase-transfected bone marrow-derived mesenchymal stem cells promote corneal allograft survival by inhibiting T cell proliferation: A rat study Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-24 Hongqin Ke, Wenjia Zhang, Wenrong Xu, Qian Cao, Lan Li, Hai Liu
Purpose Allograft rejection is still the main cause of corneal transplantation failure. Therefore, we investigated the role of indoleamine 2,3-dioxygenase (IDO)-transfected bone marrow-derived mesenchymal stem cells (IDO-BMSCs) in corneal allograft rejection in rats. Methods IDO-BMSCs were constructed and co-cultured with CD4+CD24− T cells to detect their effects on the proliferation of CD4+CD25−T
-
Examining the impact of immunosuppressive drugs on antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood natural killer (NK) cells and gamma delta (γδ) T cells Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-23 Sedigheh Jalali, Sanda Stankovic, Glen P. Westall, Patrick C. Reading, Lucy C. Sullivan, Andrew G. Brooks
Background Human natural killer (NK) cells and gamma delta (γδ) T cells may impact outcomes of solid organ transplantation (SOT) such as lung transplantation (LTx) following the differential engagement of an array of activating and inhibitory receptors. Amongst these, CD16 may be particularly important due to its capacity to bind IgG to trigger antibody-dependent cellular cytotoxicity (ADCC) and the
-
Low-dose rituximab in steroid-refractory chronic graft-versus-host disease Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-14 Perla R. Colunga-Pedraza, Luz María Barbosa-Castillo, Edgar Ulises Coronado-Alejandro, Héctor Alejandro Vaquera-Alfaro, Ingrid Gabriela López-Reyna, Julia E. Colunga-Pedraza, David Gómez-Almaguer
Background Chronic graft-versus-host disease (cGvHD) is a major complication that puts patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) at risk of death or infection. Currently, there is no gold standard for the first-line treatment of patients who do not respond to steroids, and there are several therapeutic options being evaluated in clinical trials for this disease
-
Enrichment of effector memory T cells in the CD4 and CD8 T cell compartment during chronic graft versus host disease in children Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-07 Israel Parra-Ortega, Noemí Nájera-Martínez, Félix Gaytán-Morales, Iván Castorena-Villa, Briceida López-Martínez, Vianney Ortiz-Navarrete, Irlanda Olvera-Gómez
Background During allogeneic Hematopoietic stem cell transplantation (HSCT), frequent pathological scenarios include graft versus host disease (GVHD) and viral infections. We hypothesized if exogenous stimulus as alloantigen and viral antigens might impact on central and effector memory T cells in pediatric recipients. Patients and methods Subjects included 21 pediatric recipients and 20 healthy children
-
Fallacies of a purely virtual platform: Virtual plus reality versus virtual reality – A case study Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-10 John Gnanaraj, Sam Arul Doss, S. Stephen, M. Pratheeba, Dolly Daniel
Pretransplant immunological assessment of a transplant donor has evolved significantly over the last few decades with the advent of testing platforms with enhanced sensitivity and varying formats. The single antigen bead assay (SAB) assay, a virtual crossmatch (vXM) is used extensively and considered the gold standard for defining donor-specific antibodies (DSA) in many parts of the World. A country
-
Comparative analysis of Basiliximab and Alemtuzumab induction therapies in blood type A2-to-B kidney transplantation: Impact on kidney function and de novo donor-specific HLA antibodies Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-09 Tareq Hanouneh, Rose Mary Attieh, Emily Craver, Abdullah Jebrini, Mohamed Elrefaei, Tambi Jarmi
Purpose Blood group B kidney transplant candidates have lower transplantation rates and longer waiting times compared to other blood groups. Kidney transplantation from blood group A2-to-B has offered a solution for these patients. This study aimed to investigate the impact of Basiliximab and Alemtuzumab induction therapies on kidney function and de novo donor-specific antibodies (DSA) in blood type
-
Nutritional intervention with TGF-beta enriched food for special medical purposes (TGF-FSMP) is associated with a reduction of malnutrition, acute GVHD, pneumonia and may improve overall survival in patients undergoing allogeneic hematopoietic stem transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-04 Enrico Morello, Giulia Brambilla, Simona Bernardi, Vincenzo Villanacci, Michela Carlessi, Mirko Farina, Vera Radici, Emanuela Samarani, Simone Pellizzeri, Nicola Polverelli, Alessandro Leoni, Marco Andreoli, Francesco Arena, Chiara Ricci, Michele Malagola, Domenico Russo
Malnutrition in allogeneic stem cell transplant (allo-SCT) is associated with poor outcomes. Supplementation with Foods for Special Medical Purposes may be a valid alternative to enteral nutrition or total parental nutrition to reduce malnutrition in allo-SCT. In this study, 133 patients consecutively allo-transplanted were assessed for nutritional status by Patient- Generated Subjective Global Assessment
-
Mesenchymal stem cell-derived exosomes for managing graft-versus-host disease: An updated view Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-05 Zahra Shafeghat, Maryam Dorfaki, Shiva Dehrouyeh, Fahime Lavi Arab, Mona Roozbehani, Reza Falak, Fatemeh Faraji, Reza Jafari
Graft-versus-host disease (GvHD) is the most common complication after stem cell transplantation, and also it is one of the primary limiting factors for the use of hematopoietic stem cell transplantation (HSCT) in the treatment of hematologic cancers. GvHD, a systemic inflammatory disease, is caused by donor T cells recognizing the recipient's foreign antigens. In addition, an immune dysregulation
-
Asarinin inhibits immunological rejection via the Toll-like receptor-myeloid differentiation factor 88 signaling pathway in vitro Transpl. Immunol. (IF 1.5) Pub Date : 2023-10-31 Lili Zhang, Yanxia Sun, Zhen Yang, Ping Xia
-
Thrombopoietin receptor agonists for refractory thrombocytopenia in patients after autologous hematopoietic stem cell transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-03 Dan Wang, Tao lang, Hanqing Zeng, Zhongmin Zou, Shijie Yang, Ting Cheng, Huanfeng Liu, Lidan Zhu, Xixi Xiang, Han Yao, Shuhan Tang, Peiyan Kong, Jin Wei, Jingkang Xiong, Lei Gao, Xi Zhang, Yimei Feng
Objective Autologous hematopoietic stem cell (ASC) transplantation (ASCT) is an effective treatment method for patients with hematological disorders and malignant diseases. The patient's ASCs are harvested prior to radiotherapy/chemotherapy, cryopreserved and then transfused back after the high-dose radiotherapy/chemotherapy conditioning treatment. Since some patients develop thrombocytopenia after
-
The administration of oral mucosal mesenchymal-derived stem cells improves hepatic inflammation, oxidative stress, and histopathology following traumatic brain injury Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-02 Eshagh Alizadeh, Nazanin Sabet, Zahra Soltani, Mohammad Khaksari, Elham Jafari, Saeed Karamouzian
Background The inflammatory mediators produced after traumatic brain injury (TBI) are reaching peripheral organs causing organ and tissue damage, including the liver. Our study assessed the effect of intravenous (i.v.) infusion of oral mesenchymal stem cells (OMSCs) on TBI-induced liver damage by measuring liver inflammatory factors and liver oxidative stress. Methods Twenty-eight adult male Wistar
-
Therapeutic strategies against BK polyomavirus infection in kidney transplant recipients: Systematic review and meta-analysis Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-04 Cuiyu Zhong, Jiayi Chen, Ziyan Yan, Renfei Xia, Wenli Zeng, Wenfeng Deng, Jian Xu, Yuchen Wang, Yun Miao
Background The selection of antiviral therapy for BK polyomavirus (BKPyV) infection has been extensively debated. Our study aimed to assess the efficacy and safety of various treatments for BKPyV infection. Methods We searched PubMed, EMBASE, and Web of Science databases for relevant studies regarding drug treatments for BKPyV viremia/DNAemia published between January 1, 1970 and September 30, 2022
-
HLA B eplet mismatches in the context of delayed graft function and low tacrolimus trough levels are risk factors influencing the generation of de novo donor-specific antibodies and acute rejection in the early stage after kidney transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-04 Shan Gao, Huilin Gong, Meihe Li, Ping Lan, Minyue Zhang, Peidan Kuang, Ying Zhang, Xiaojun Hu, Chenguang Ding, Yang Li, Xiaoming Ding, Wujun Xue, Jin Zheng
Background De novo donor-specific antibody (dnDSA) generation and acute rejection (AR) are the main factors affecting long-term graft survival. This study aims to investigate human leukocyte antigen (HLA) eplet mismatching (MM), delayed graft function (DGF), and tacrolimus (TAC) trough levels on the occurrence of dnDSA and AR in the early stages after kidney transplantation (KT). Methods This retrospective
-
Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-11-02 Don Luu, Tariq Shah, Prashant Sakharkar, David I. Min
Background Genetic variations in Sestrin2/Sestrin3/ mTOR axis may cause obesity-associated metabolic syndrome, including lipid accumulation and insulin resistance thereby increasing individual's risk of diabetes. In this study, we explored the association between single nucleotide polymorphisms (SNPs) of these genes and new onset diabetes after transplantation in Hispanic renal transplant recipients
-
Temsirolimus is a promising immunomodulatory agent for enhanced transplantation outcomes Transpl. Immunol. (IF 1.5) Pub Date : 2023-10-31 Xianguo Li, Zuojie Peng, Ke An, Mengjiao Xue, Zhenzhen Wang, Junjie Xia, Zhongquan Qi, Xiaogang Shu
Background Identifying effective immunosuppressive strategies is critical for addressing immunological rejection following organ transplantation. This study explores the potential immunosuppressive effects and mechanisms of temsirolimus, a rapamycin derivative, in organ transplantation. Methods A mouse cardiac allograft model was established using a cervical cannula technique with BALB/c donors and
-
The frequency of peripheral PD-1+ TCD4+ cells is reversely associated with serum creatinine levels in recipients of kidney allografts Transpl. Immunol. (IF 1.5) Pub Date : 2023-10-31 Alireza Mardomi, Maryam KarajiBani, Farahnoosh Farnood, Sepideh Zununi Vahed, Mohmmadreza Ardalan
The long-term survival of solid organ allografts remains a challenge for organ transplantation systems worldwide. T-cell exhaustion has been supposed to be associated with immunologic tolerance in transplantation and might reflect the immunologic status in recipients. The aim of the present study was to compare the TCD4+ cells of kidney transplant recipients with high and low serum creatinine levels
-
Research progress on CD8+ T cell immune regulation in allogenic transplantation Transpl. Immunol. (IF 1.5) Pub Date : 2023-10-21 Haowen Jiang, Wenmei Fan
With advances in tissue typing, organ preservation techniques, and clinical surgery, organ transplantation has gained popularity as a treatment option for various end-stage diseases. Allogeneic transplantation has been widely adopted and extensively researched in clinical practice. Despite significant breakthroughs and progress in immunosuppression, this procedure is still associated with several adverse