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Applications of Engineered Skin Tissue for Cosmetic Component and Toxicology Detection Cell Transplant. (IF 3.3) Pub Date : 2024-03-16 Min Wang, Linfeng Zhang, Haojie Hao, Muyang Yan, Ziying Zhu
The scale of the cosmetic market is increasing every day. There are many safety risks to cosmetics, but they benefit people at the same time. The skin can become red, swollen, itchy, chronically toxic, and senescent due to the misuse of cosmetics, triggering skin injuries, with contact dermatitis being the most common. Therefore, there is an urgent need for a system that can scientifically and rationally
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Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury Cell Transplant. (IF 3.3) Pub Date : 2024-03-14 Ya-Ni Huang, Nigel H. Greig, Pen-Sen Huang, Yung-Hsiao Chiang, Alan Hoffer, Chih-Hao Yang, David Tweedie, Ying Chen, Ju-Chi Ou, Jia-Yi Wang
Neuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation
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Prospects for the Application of Transplantation With Human Amniotic Membrane Epithelial Stem Cells in Systemic Lupus Erythematosus Cell Transplant. (IF 3.3) Pub Date : 2024-03-12 Liping Xu, Qiaoding Dai, Yan Zhang, Na Lin, Lina Ji, Xinwei Song
Systemic lupus erythematosus (SLE) is a multi-organ and systemic autoimmune disease characterized by an imbalance of humoral and cellular immunity. The efficacy and side effects of traditional glucocorticoid and immunosuppressant therapy remain controversial. Recent studies have revealed abnormalities in mesenchymal stem cells (MSCs) in SLE, leading to the application of bone marrow-derived MSCs (BM-MSCs)
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Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study Cell Transplant. (IF 3.3) Pub Date : 2024-03-07 Fatima Jamali, Mayis Aldughmi, Serin Atiani, Ali Al-Radaideh, Said Dahbour, Dana Alhattab, Hind Khwaireh, Sally Arafat, Joud Al Jaghbeer, Reem Rahmeh, Kawthar Abu Moshref, Hisham Bawaneh, Mona R. Hassuneh, Bayan Hourani, Osameh Ababneh, Alia Alghwiri, Abdalla Awidi
Multiple sclerosis (MS) is a chronic neuro-inflammatory disease resulting in disabilities that negatively impact patients’ life quality. While current treatment options do not reverse the course of the disease, treatment using mesenchymal stromal/stem cells (MSC) is promising. There has yet to be a consensus on the type and dose of MSC to be used in MS. This work aims to study the safety and efficacy
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The Progress and Prospects of Immune Cell Therapy for the Treatment of Cancer Cell Transplant. (IF 3.3) Pub Date : 2024-03-04 Jia Han, Bowen Zhang, Senyu Zheng, Yuan Jiang, Xiaopeng Zhang, Kaiyun Mao
Immune cell therapy as a revolutionary treatment modality, significantly transformed cancer care. It is a specialized form of immunotherapy that utilizes living immune cells as therapeutic reagents for the treatment of cancer. Unlike traditional drugs, cell therapies are considered “living drugs,” and these products are currently customized and require advanced manufacturing techniques. Although chimeric
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GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats Cell Transplant. (IF 3.3) Pub Date : 2024-02-24 Xixi Li, Jiakun Xu, Weijie Su, Luoxi Su, Xiangkun Chen, Jia Yang, Xunxun Lin, Lixuan Yang
Spinal cord injury (SCI) severely affects the quality of life and autonomy of patients, and effective treatments are currently lacking. Autophagy, an essential cellular metabolic process, plays a crucial role in neuroprotection and repair after SCI. Glycoprotein non-metastatic melanoma protein B (GPNMB) has been shown to promote neural regeneration and synapse reconstruction, potentially through the
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Changes in the Proportion of Each Cell Type After hiPSC-Derived Airway Epithelia Transplantation Cell Transplant. (IF 3.3) Pub Date : 2024-02-19 Masayuki Kitano, Yasuyuki Hayashi, Hiroe Ohnishi, Hideaki Okuyama, Masayoshi Yoshimatsu, Keisuke Mizuno, Fumihiko Kuwata, Takeshi Tada, Yo Kishimoto, Satoshi Morita, Koichi Omori
No radical treatment is available for the regeneration of dysfunction and defects in airway epithelia. Artificial tracheae made of polypropylene and collagen sponge were used in clinical studies to reconstitute tracheae after resection. For early epithelialization of the luminal surface of the artificial trachea, a model was established, that is, an artificial trachea covered with human-induced pluripotent
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Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice Cell Transplant. (IF 3.3) Pub Date : 2024-02-14 Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies. Neutrophils—the primary defenders of the human immune system—have potent bactericidal capabilities. Here, we investigated the dynamic in vivo distribution of neutrophil transfusion and their impact on the treatment outcome of severe granulocytopenic
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Human Placenta-Derived Mesenchymal Stem Cells Combined With Artificial Dermal Scaffold Enhance Wound Healing in a Tendon-Exposed Wound of a Rabbit Model Cell Transplant. (IF 3.3) Pub Date : 2024-02-09 Fang Li, Cong Gao, Guodong Song, Kun Zhang, Guobao Huang, Hua Liu
To overcome the difficulty of vascular regeneration in exposed tendon wounds, we combined human placenta-derived mesenchymal stem cells (hPMSCs) with an artificial dermal scaffold and assessed their role in promoting vascular regeneration and wound healing in vivo. hPMSCs were isolated from the human placenta and characterized based on their morphology, phenotypic profiles, and pluripotency. New Zealand
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Xenogenic Application of Human Placenta-Derived Mesenchymal Stromal Cells in a Porcine Large Animal Model Cell Transplant. (IF 3.3) Pub Date : 2024-02-07 Niklas Harland, Jasmin Knoll, Bastian Amend, Tanja Abruzzese, Harald Abele, Peter Jakubowski, Arnulf Stenzl, Wilhelm K. Aicher
In animal models, cell therapies for different diseases or injuries have been very successful. Preclinical studies with cells aiming at a stroke, heart attack, and other emergency situations were promising but sometimes failed translation in clinical situations. We, therefore, investigated if human placenta-derived mesenchymal stromal cells can be injected in pigs without provoking rejection to serve
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RNA-Seq Analysis Reveals Potential Neuroprotective Mechanisms of Pachymic Acid Toward Iron-Induced Oxidative Stress and Cell Death Cell Transplant. (IF 3.3) Pub Date : 2024-02-05 Shuyang Hu, Baili Yang, Binbin Li, Qianqian Fan, Tinglong Wu, Shanshan Li, Dong Wang, Tao Yang, Zhenghua Song
Iron dysregulation is a crucial factor in the development of neurological diseases, leading to the accumulation of reactive oxygen species (ROS) and oxidative stress, triggering inflammatory responses, and ultimately causing neurological impairment. Pachymic acid (PA) is an active ingredient extracted from the medicinal fungus Poria cocos, which has been reported with multiple pharmacological effects
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Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy Cell Transplant. (IF 3.3) Pub Date : 2024-01-30 Xi Zhang, Yan Jiao, Tong Shen, Yuanman Yu, Zhou Yu, Juanli Dang, Lin Chen, Yu Zhang, Guofang Shen
Ischemic wounds are chronic wounds with poor blood supply that delays wound reconstruction. To accelerate wound healing and promote angiogenesis, adipose-derived stem cells (ADSCs) are ideal seed cells for stem cell–based therapies. Nevertheless, providing a favorable environment for cell proliferation and metabolism poses a substantial challenge. A highly sulfated heparin-like polysaccharide 2-N,
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Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients With Acute Myeloid Leukemia Harboring KMT2A Rearrangement and Its Prognostic Factors Cell Transplant. (IF 3.3) Pub Date : 2024-01-25 Bingqian Jiang, Yanmin Zhao, Yi Luo, Jian Yu, Yi Chen, Baodong Ye, Huarui Fu, Xiaoyu Lai, Lizhen Liu, Yishan Ye, Weiyan Zheng, Jie Sun, Jingsong He, Yi Zhao, Guoqing Wei, Zhen Cai, He Huang, Jimin Shi
KMT2A rearrangement ( KMT2A-r) in patients with acute myeloid leukemia (AML) is associated with poor outcomes; the prognostic factors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear. We investigated 364 adults with AML who underwent allo-HSCT between April 2016 and May 2022, and 45 had KMT2A-r among them. Propensity score analysis with 1:1 matching and the nearest
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Mitigating Cross-Species Viral Infections in Xenotransplantation: Progress, Strategies, and Clinical Outlook Cell Transplant. (IF 3.3) Pub Date : 2024-01-23 Yenong Zhou, Shuyu Zhou, Qian Wang, Bing Zhang
Xenotransplantation holds great promise as a solution to address the critical shortage of organs, but it raises concerns regarding the potential transmission of porcine viruses to recipients, leading to infections and even zoonotic diseases. Data used in this review were mainly from literature of Pubmed database. Keywords included xenotransplantation, infection, virus, and epidemiology. The original
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Effect of High BMI on Human Bone Marrow–Derived Mesenchymal Stromal Cells Cell Transplant. (IF 3.3) Pub Date : 2024-01-23 Qiang Zong, Katrin Bundkirchen, Claudia Neunaber, Sandra Noack
Bone marrow–derived mesenchymal stromal cells (BMSCs) are attractive candidates in tissue engineering and regenerative medicine. Growing evidence has suggested that a high body mass index (BMI) can affect the properties of BMSCs, resulting in a reduced quality of the cells. However, the results are not consistent. Therefore, this study aimed to investigate the influences of high BMI on human BMSCs
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Withania Somnifera Extract Mitigates Experimental Acute Graft versus Host Disease Without Abrogating Graft Versus Leukemia Effect Cell Transplant. (IF 3.3) Pub Date : 2024-01-23 Saurabh Kumar Gupta, Dievya Gohil, Mohd Bashar Momin, Subhash Yadav, Akanksha Chichra, Sachin Punatar, Anant Gokarn, Sumeet Mirgh, Nishant Jindal, Lingaraj Nayak, Lal Hingorani, Navin Khattry, Vikram Gota
Acute graft versus host disease (aGvHD) is the major contributor of nonrelapse mortality in alloHSCT. It is associated with an inflammatory immune response manifesting as cytokine storm with ensuing damage to target organs such as liver, gut, and skin. Prevention of aGvHD while retaining the beneficial graft versus leukemia (GvL) effect remains a major challenge. Withania somnifera extract (WSE) is
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Firefly Rats: Illuminating the Scientific Community in Transplantation Research Cell Transplant. (IF 3.3) Pub Date : 2024-01-18 Eiji Kobayashi, Yoji Hakamata, Shin Enosawa, Kuang-Ming Shang, Hirotake Komatsu
Fireflies produce light through luciferase-catalyzed reactions involving luciferin, oxygen, and adenosine triphosphate, distinct from other luminescent organisms. This unique feature has revolutionized molecular biology and physiology, serving as a valuable tool for cellular research. Luciferase-based bioluminescent imaging enabled the creation of transgenic animals, such as Firefly Rats. Firefly Rats
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Stem Cells and Their Derivatives: Unlocking the Promising Potential of Minimally Manipulated Cells for In Situ Tissue Engineering Cell Transplant. (IF 3.3) Pub Date : 2024-01-18 Ilya Klabukov, Denis Baranovskii
We’ve read with great interest the article by Smolinska et al. entitled “Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures” regarding the recent scientific studies dealing with the treatment of nonunion fractures in clinical and preclinical settings using Mesenchymal Stem Cell (MSC)-based therapeutic techniques. Bone tissue regeneration is a dynamic process
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A Comparison Between GalT−/−;hCD39;hCD55 and GalT−/−;hCD39;hCD46;hCD55;TBM Pig Kidneys Transplanted in Nonhuman Primates Cell Transplant. (IF 3.3) Pub Date : 2024-01-17 Han Na Suh, Ju Young Lee, Hee Jung Kang, Eun Mi Park, Ik Jin Yun, Wan Seop Kim, Kimyung Choi, Jeong Ho Hwang
Because there is a shortage of donor kidneys, researchers are exploring the possibility of using genetically modified pig kidneys for transplantation. Approaches involving knockout of carbohydrate genes or knockin of protective proteins have been attempted to determine the best gene modifications. In this study, we utilized GalT−/−; hCD39;hCD55 and GalT−/−; hCD39;hCD46;hCD55;thrombomodulin (TBM) pigs
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Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm Cell Transplant. (IF 3.3) Pub Date : 2024-01-11 Cheng-Fong Chen, Yi-Chung Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Wei-Ming Chen, Hung-Ta Hondar Wu, Chia-Hsin Lee, Chao-Liang Chang, Po-Cheng Lin, Yong-Cheng Kao, Chun-Hung Chen, Ming-Hsi Chuang
The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts: low dose (6.7 × 106 GXCPC1, N = 5) and high dose (4 × 107 GXCPC1, N = 6). The primary endpoint was safety
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Ultrasound-Targeted Microbubble Destruction Increases BBB Permeability and Promotes Stem Cell–Induced Regeneration of Stroke by Downregulating MMP8 Cell Transplant. (IF 3.3) Pub Date : 2024-01-09 Yun Bai, Yichao Du, Yin Yang, Thomas Wälchli, Paul E Constanthin, Fan Li
The objective of this study was to evaluate the feasibility, safety, and effectiveness of intravenous stem cell delivery utilizing ultrasound-targeted microbubble destruction (UTMD) in a rat model of middle cerebral artery occlusion (MCAO), while investigating the underlying mechanisms. Acute cerebral infarction (ACI) was induced surgically in adult rats to create the MCAO rat model. Intravenous injection
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Relapsed/Refractory Peripheral T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis With UNC13D and CD27 Germline Mutations Cell Transplant. (IF 3.3) Pub Date : 2024-01-06 Tingting Yang, Rongrong Chen, Mingming Zhang, Ruirui Jing, Jia Geng, Guoqing Wei, Yi Luo, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Shan Fu, Houli Zhao, Jiazhen Cui, Simao Huang, He Huang, Yongxian Hu
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory disease characterized by familial and acquired forms. Here, we present the case of a 26-year-old male patient with relapsed/refractory peripheral T-cell lymphoma and concurrent HLH. Whole-exon sequencing revealed germline mutations associated with HLH, including those in critical genes such as CD27 and UNC13D and other germline
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Preclinical Animal Study and Pilot Clinical Trial of Using Enriched Peripheral Blood-Derived Mononuclear Cells for Intervertebral Disc Degeneration Cell Transplant. (IF 3.3) Pub Date : 2024-01-04 Yu-Hsuan Chung, Ming-Hsien Hu, Shang-Chyi Kao, Ying-Hsien Kao, Fu-Hui Wang, Chia-Ying Hsieh, Ching-I Shen, Chang-Han Chuang, Dave Wei-Chih Chen, Chi-Chung Kuo, Hong-Lin Su, Chih-Lung Lin
Low back pain (LBP) is a leading cause of long-term disability globally. Intervertebral disk degeneration (IVDD) is mainly responsible for discogenic pain in LBP-affected young patients. There is no effective therapy to reverse disease severity and IVDD progression. This study investigates the effect of human peripheral blood-derived mononuclear cells (PBMCs) on pain relief and life quality improvement
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Repairing Effect of Mesenchymal Stem Cells on Lead Acetate-Induced Testicular Injury in Mice Cell Transplant. (IF 3.3) Pub Date : 2024-01-04 Shasha Zhao, Zhaozhi Li, Kun Li, Xiaoyu Dai, Zhe Xu, Li Li, Huanhuan Wang, Xiaodun Liu, Dong Li
Lead acetate can cause testicular damage in males. In this study, we assessed the repairing effects of human umbilical cord mesenchymal stem cells (MSCs) on testicular injury caused by lead acetate in mice. MSCs were injected into mice with testicular injury by intraperitoneal injection, and the organ coefficient of reproductive organs, sperm motility, hormone level and antioxidant index of mice were
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Multifaceted Characterization of Human Embryonic Stem Cell-Derived Mesenchymal Stem/Stromal Cells Revealed Amelioration of Acute Liver Injury in NOD-SCID Mice Cell Transplant. (IF 3.3) Pub Date : 2024-01-04 Youlai Zhang, Ying He, Rufei Deng, Zhenyu Jiang, Leisheng Zhang, Yuanlin Zeng, Lijin Zou
Human embryonic stem cells (hESCs) are advantaged sources for large-scale and homogeneous mesenchymal stem/stromal cells (MSCs) generation. However, due to the limitations in high-efficiency procedures for hESC-MSCs induction, the systematic and detailed information of mesengenesis and early MSC development are largely obscure. In this study, we took advantage of the well-established twist-related
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Proliferation and Differentiation Potential of Bone Marrow–Derived Mesenchymal Stem Cells From Children With Polydactyly and Adults With Basal Joint Arthritis Cell Transplant. (IF 3.3) Pub Date : 2024-01-02 Shih-Han Yeh, Jin-Huei Yu, Po-Hsin Chou, Szu-Hsien Wu, Yu-Ting Liao, Yi-Chao Huang, Tung-Ming Chen, Jung-Pan Wang
This study compared the proliferation and differentiation potential of bone marrow–derived mesenchymal stem cells (BMSCs) derived from infants with polydactyly and adults with basal joint arthritis. The proliferation rate of adult and infant BMSCs was determined by the cell number changes and doubling times. The γH2AX immunofluorescence staining, age-related gene expression, senescence-associated β-galactosidase
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Pericardial Grafting of Cardiac Progenitor Cells in Self-Assembling Peptide Scaffold Improves Cardiac Function After Myocardial Infarction Cell Transplant. (IF 3.3) Pub Date : 2023-05-16 Masato Kanda, Toshio Nagai, Naomichi Kondo, Katsuhisa Matsuura, Hiroshi Akazawa, Issei Komuro, Yoshio Kobayashi
Many studies have explored cardiac progenitor cell (CPC) therapy for heart disease. However, optimal scaffolds are needed to ensure the engraftment of transplanted cells. We produced a three-dimens...
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Exosomes From Adipose-Derived Stem Cells Suppress the Progression of Chronic Endometritis Cell Transplant. (IF 3.3) Pub Date : 2023-05-16 Bin Wang, Li Li, Ruizhu Yu
Chronic endometritis (CE) is closely linked to the reproductive failure. Exosome (Exo)-based therapy is proposed as an encouraging strategy in inflammation-related disorders; however, little work h...
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Combinational Treatment Involving Decellularized Extracellular Matrix Hydrogels With Mesenchymal Stem Cells Increased the Efficacy of Cell Therapy in Pancreatitis Cell Transplant. (IF 3.3) Pub Date : 2023-05-16 Hideaki Kojima, Hiroko Kushige, Hiroshi Yagi, Takayuki Nishijima, Nobuko Moritoki, Narihito Nagoshi, Yutaka Nakano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Minoru Kitago, Masaya Nakamura, Yuko Kitagawa
Cell transplantation using mesenchymal stem cells (MSCs) has emerged as a promising approach to repairing and regenerating injured or impaired organs. However, the survival and retention of MSCs fo...
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In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells Cell Transplant. (IF 3.3) Pub Date : 2023-05-15 Ittetsu Nakajima, Takahiro Tsukimura, Terumi Ono, Tomoko Shiga, Hiroshi Shitara, Tadayasu Togawa, Hitoshi Sakuraba, Yuichiro Miyaoka
Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid e...
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Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats Cell Transplant. (IF 3.3) Pub Date : 2023-04-27 Jolien R. Nijns, Ines De Mesmaeker, Krista G. Suenens, Geert M. Stangé, Kaat De Groot, Maria Marques de Lima, Marine R. C. Kraus, Bart Keymeulen, Wim Waelput, Daniel Jacobs-Tulleneers Thevissen, Daniel G. Pipeleers
Subcutaneous implants of device-encapsulated stem cell–derived pancreatic endoderm (PE) can establish a functional beta cell mass (FBM) with metabolic control in immune-compromised mice. In a study...
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Expandable Sendai-Virus-Reprogrammed Human iPSC-Neuronal Precursors: In Vivo Post-Grafting Safety Characterization in Rats and Adult Pig Cell Transplant. (IF 3.3) Pub Date : 2023-04-23 Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Jr., Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cel...
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Ultrasound-Guided Perineural Vitamin B12 Injection for Brachial Plexus Injury: A Preliminary Study Cell Transplant. (IF 3.3) Pub Date : 2023-04-21 Chien-Hua Chen, Hung-Ya Huang, Abel Po-Hao Huang, Fu-Shan Jaw, Meng-Chao Chen, Chii-Wann Lin, Shang-Po Wang
Individuals with brachial plexus injury (BPI) require upper limb function restoration, but the treatment remains controversial. Vitamin B12 may aid in pain control and nerve regeneration. We presen...
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Mapping of the Human Amniotic Membrane: In Situ Detection of Microvesicles Secreted by Amniotic Epithelial Cells Cell Transplant. (IF 3.3) Pub Date : 2023-04-19 Mariangela Basile, Lucia Centurione, Francesca Passaretta, Gianmarco Stati, Olga Soritau, Sergiu Susman, Florelle Gindraux, Antonietta Silini, Ornella Parolini, Roberta Di Pietro
The potential clinical applications of human amniotic membrane (hAM) and human amniotic epithelial cells (hAECs) in the field of regenerative medicine have been known in literature since long. Howe...
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Minimally Invasive Sub-Retinal Transplantation of RPE-J Cells on a Biodegradable Composite PCL/Collagen Nanosheet Cell Transplant. (IF 3.3) Pub Date : 2023-04-11 Kazuya Yamashita, Serge Ostrovidov, Bibek Raut, Takeshi Hori, Yuji Nashimoto, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji
Retinal cells are irreparably damaged by diseases such as age-related macular degeneration (AMD). A promising method to restore partial or whole vision is through cell-based transplantation to the ...
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circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response Cell Transplant. (IF 3.3) Pub Date : 2023-04-07 Yinglang Zhang, Zhi Li, Yu Zhang, Chong Shen, Zhe Zhang, Xiaolei Ren, Changgang Guo, Shaobo Yang, Zejin Wang, Hailong Hu
A growing body of evidence shows that circular RNAs (circRNAs) participate in tumor growth and metastasis and also play crucial roles in the treatment and prognosis of various cancers. In this arti...
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Mesenchymal Stem Cell Therapy in Kidney Diseases: Potential and Challenges Cell Transplant. (IF 3.3) Pub Date : 2023-04-03 Fukun Chen, NaNa Chen, Chunjuan Xia, Hongyue Wang, Lishi Shao, Chen Zhou, Jiaping Wang
Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. Howe...
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Comparable Outcomes of Pre- Versus Post-Tyrosine Kinase Inhibitor Era Treatment in Chronic Myeloid Leukemia: A Retrospective Cohort Study With Long-term Follow-up Cell Transplant. (IF 3.3) Pub Date : 2023-04-03 Sahar Tavakoli, Fattaneh Khalaj, Amir Kasaeian, Seyed Ali Mousavi, Amir-Hossein Mousavian, Fatemeh Arabi, Soroush Rad, Shahrbano Rostami, Maryam Barkhordar, Mohammad Biglari, Heydar Ali Mardani-Fard, Hediyeh Alemi, Naghmeh Khavandgar, Hossein Kamranzadeh Fumani, Ghasem Janbabai, Seied Asadollah Mousavi, Ardeshir Ghavamzadeh, Mohammad Vaezi
Imatinib, a selective BCR-ABL tyrosine kinase inhibitor (TKI), was introduced after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with chronic myeloid leukemia (CML). ...
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Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? Cell Transplant. (IF 3.3) Pub Date : 2023-04-02 Klearchos K. Papas, Charles W. Putnam, Robert C. Johnson, Athanassios Sambanis
Transplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released ...
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Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review Cell Transplant. (IF 3.3) Pub Date : 2023-03-31 Makoto Nabetani, Takeo Mukai, Akihiko Taguchi
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social communication, repetitive behaviors, and restricted interests, with onset early in li...
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Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis Cell Transplant. (IF 3.3) Pub Date : 2023-03-31 Haijun Li, Huiling Cui, Jing Ren, Di Wang, Rumeng Zhao, Shichao Zhu, Siqing Liu, Xiaohui Liu, Shuai Tian, Yuanyuan Zhang, Panpan Zhao, Peng Li, Rick F. Thorne, Shichao Duan
Glaucoma including primary open-angle glaucoma (POAG) results from elevations in intraocular pressure (IOP). An eye-localized renin-angiotensin system (RAS) has been implicated in IOP regulation, a...
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Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization Cell Transplant. (IF 3.3) Pub Date : 2023-03-23 Michiko Shigyo, Yoshiomi Kobayashi, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato Jr, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Joseph D. Ciacci, Martin Marsala
The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in v...
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Notch Signaling-Modified Mesenchymal Stem Cell Patch Improves Left Ventricular Function via Arteriogenesis Induction in a Rat Myocardial Infarction Model Cell Transplant. (IF 3.3) Pub Date : 2023-03-22 Shusaku Maeda, Takuji Kawamura, Dai Chida, Kazuo Shimamura, Koichi Toda, Akima Harada, Yoshiki Sawa, Shigeru Miyagawa
For ischemic cardiomyopathy (ICM) with limited therapeutic options, the induction of arteriogenesis has the potential to improve cardiac function through major restoration of blood flow. We hypothe...
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In Silico Stage-Matching of Human, Marmoset, Mouse, and Pig Embryos to Enhance Organ Development Through Interspecies Chimerism Cell Transplant. (IF 3.3) Pub Date : 2023-03-17 Anala Shetty, Seunghyun Lim, Phoebe Strell, Clifford J. Steer, Juan Carlos Rivera-Mulia, Walter C. Low
Currently, there is a significant shortage of transplantable organs for patients in need. Interspecies chimerism and blastocyst complementation are alternatives for generating transplantable human ...
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Impact of Lymphocyte Subsets of Grafts on the Outcome of Haploidentical Peripheral Blood Stem Cell Transplantation Cell Transplant. (IF 3.3) Pub Date : 2023-03-11 Peiyao Jiang, Fangfang Yu, Xiaowei Xu, Yu Cai, Jun Yang, Yin Tong, Chongmei Huang, Huiying Qiu, Kun Zhou, Ying Zhang, Jiahua Niu, Chang Shen, Xinxin Xia, Yu Wei, Jie Shao, Lu Gao, Xianmin Song, Liping Wan
The contribution of lymphocyte subset composition of the graft on the outcomes following haploidentical peripheral blood stem cell transplantation (haploPBSCT) is not fully elucidated. We retrospec...
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Comparison of the Cost and Effect of Combined Conditioned Medium and Conventional Medium for Fallopian Tube Organoid Cultures Cell Transplant. (IF 3.3) Pub Date : 2023-03-15 Yu-Hsun Chang, Kun-Chi Wu, Tomor Harnod, Dah-Ching Ding
Fallopian tube epithelial cells (FTEC) are thought to be the cell of origin of high-grade serous ovarian carcinoma. FTEC organoids can be used as research models for the disease. Nevertheless, cult...
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Stem Cells: Recent Developments Redefining Epilepsy Therapy Cell Transplant. (IF 3.3) Pub Date : 2023-03-15 Adam Alayli, Gavin Lockard, Jonah Gordon, Jacob Connolly, Molly Monsour, Samantha Schimmel, Ike Dela Peña, Cesar V. Borlongan
The field of stem cell therapy is growing rapidly and hopes to offer an alternative solution to diseases that are historically treated medically or surgically. One such focus of research is the tre...
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Endometrial Stem Cells and Their Applications in Intrauterine Adhesion Cell Transplant. (IF 3.3) Pub Date : 2023-03-09 Kai Chen, Shengxia Zheng, Fang Fang
Intrauterine adhesion (IUA), resulting from pregnancy or nonpregnant uterine trauma, is one of the major causes of abnormal menstruation, infertility, or repeated pregnancy loss. Although a few met...
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Donor Hematopoietic Stem Cell/Lymphocyte Maintenance Treatment After CAR T-Cell Therapy in Patients With B-Cell Acute Lymphoblastic Leukemia Relapse Following Stem Cell Transplant Cell Transplant. (IF 3.3) Pub Date : 2023-03-06 Qing Li, Cuicui Lyu, Meijing Liu, Jia Wang, Nan Mou, Erlie Jiang, Rongli Zhang, Qi Deng
Maintaining the efficacy of anti-CD19 chimeric antigen receptor modified (CAR) T-cell therapy in patients with B-cell acute lymphoblastic leukemia (B-ALL) relapse after allogeneic hematopoietic ste...
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Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 Cell Transplant. (IF 3.3) Pub Date : 2023-02-28 Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu, Baoshan Wang
Long noncoding RNAs (lncRNAs) have an effect on the occurrence and progression of a considerable number of diseases, especially cancer. Existing research has suggested that MAGI2 antisense RNA 3 (M...
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In Situ-Formed Fibrin Hydrogel Scaffold Loaded With Human Umbilical Cord Mesenchymal Stem Cells Promotes Skin Wound Healing Cell Transplant. (IF 3.3) Pub Date : 2023-02-25 Lvzhong Hu, Jinhua Zhou, Zhisong He, Lin Zhang, Fangzhou Du, Mengting Nie, Yao Zhou, Hang Hao, Lixing Zhang, Shuang Yu, Jingzhong Zhang, Youguo Chen
Healing of full-thickness skin wounds remains a major challenge. Recently, human umbilical cord mesenchymal stem cells (hUC-MSCs) were shown to possess an extraordinary potential to promote skin re...
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Are the Costimulatory Molecule Gene Polymorphisms (CTLA-4) Associated With Infection in Organ Transplantation? A Meta-Analysis Cell Transplant. (IF 3.3) Pub Date : 2023-02-25 Mahdiyar Iravani Saadi, Mingjun Jiang, Morteza Banakar, Fatemeh Mardani Valandani, Maryam Ahmadyan, Hossain Ali Rostamipour, Nadiya Kheradmand, Nasrin Noshadi, Zahed Karimi, Ehsan Nabi Abdolyousefi, Mani Ramzi, Hourvash Haghighinejad, Ramin Yaghobi, Fakhroddin Hosseini
Organ transplantation has been linked to certain gene polymorphisms. The effect of gene polymorphisms–associated organ transplantation gene on infection, on the other hand, is yet unknown. The rese...
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Stem Cell Therapies for Intracerebral Hemorrhage: Review of Preclinical and Clinical Studies Cell Transplant. (IF 3.3) Pub Date : 2023-02-23 Soichiro Takamiya, Masahito Kawabori, Miki Fujimura
Despite recent developments in the treatments for ischemic stroke, such as tissue plasminogen activator (t-PA) and thrombectomy, effective therapies for intracerebral hemorrhage (ICH) remain scarce...
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Human Menstrual Blood–Derived Endometrial Stem Cells Promote Functional Recovery by Improving the Inflammatory Microenvironment in a Mouse Spinal Cord Injury Model Cell Transplant. (IF 3.3) Pub Date : 2023-02-14 Yaping Shi, Yunfei Liu, Bichao Zhang, Xiaoying Li, Juntang Lin, Ciqing Yang
Spinal cord injury (SCI) is a traumatic injury of the central nervous system. Because neurons are damaged and difficult to regenerate after SCI, its repair remains challenging. However, recent rese...
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Clinical Outcomes by Consolidation of Bone Marrow Stem Cell Therapy and Coronary Artery Bypass Graft in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-analysis Cell Transplant. (IF 3.3) Pub Date : 2023-02-14 Yinhao Jiang, Ziying Yang, Lianbo Shao, Han Shen, Xiaomei Teng, Yihuan Chen, Yinglong Ding, Jiaming Fan, You Yu, Zhenya Shen
Bone marrow stem cell (BMSC) transplantation during coronary artery bypass graft (CABG) is an innovative treatment for ischemic heart disease (IHD). We conduct a meta-analysis to examine whether pa...
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Enriched Peripheral Blood-Derived Mononuclear Cells for Treating Knee Osteoarthritis Cell Transplant. (IF 3.3) Pub Date : 2023-01-20 Chang-Han Chuang, Chi-Chung Kuo, Yueh-Feng Chiang, Pei-Yuan Lee, Fu-Hui Wang, Chia-Ying Hsieh, Ching-I Shen, Yu-Hsuan Chung, Kuan-Der Lee, Shih-Fang Wu, Hong-Lin Su, Chih-Lung Lin
Osteoarthritis (OA) is a common chronic skeletal disease in the elderly. There is no effective therapy to reverse disease severity and knee OA (KOA) progression, particularly at the late stage. Thi...
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Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs Cell Transplant. (IF 3.3) Pub Date : 2023-01-20 Yi-jing Liu, Hai-bing Miao, Shu Lin, Zhen Chen
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease associated with impaired organ functions that can seriously affect the daily life of patients. Recent SLE therapies frequ...
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CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response Cell Transplant. (IF 3.3) Pub Date : 2023-01-16 Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong, Wei Wang
Clinically, xenotransplantation often leads to T-cell-mediated graft rejection. Immunosuppressive agents including polyclonal regulatory T cells (poly-Tregs) promote global immunosuppression, resul...
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Xenotransplantation: Current Challenges and Emerging Solutions Cell Transplant. (IF 3.3) Pub Date : 2023-01-16 Tarek Ziad Arabi, Belal Nedal Sabbah, Amir Lerman, Xiang-Yang Zhu, Lilach O. Lerman
To address the ongoing shortage of organs available for replacement, xenotransplantation of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing xenotransplants i...
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VEGF-Expressing Mesenchymal Stem Cell Therapy for Safe and Effective Treatment of Pain in Parkinson’s Disease Cell Transplant. (IF 3.3) Pub Date : 2023-01-12 Man Li, Ji Li, Hong Chen, Mingxin Zhu
Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor that mediates the differentiation and function of vascular endothelial cells. VEGF has been implicated in modulating various pai...