-
What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation (IF 6.2) Pub Date : 2024-03-18 Eliano Bonaccorsi-Riani, Davide Ghinolfi, Zoltan Czigany, Daniele Dondossola, Juliet Emamaullee, Muhammed Yuksel, Yuri L Boteon, David Al-Adra, Cheng-Maw Ho, Maen Abdelrahim, Li Pang, Andrew Barbas, Raphael Meier, Sonya MacParland, Blayne Amir Sayed, Juliana Pavan-Guimaraes, Isabel M A Brüggenwirth, Ali Zarrinpar, Valeria R Mas, Markus Selzner, Paulo N Martins, Mamatha Bhat
The 2023 Joint Annual Congress of the International Liver Transplantation Society, European Liver and Intestine Transplant Association, and Liver Intensive Care Group of Europe were held in Rotterdam, the Netherlands, from May 3 to 6, 2023. This year, all speakers were invited to attend the Congress in person for the first time since the COVID-19 pandemic. The congress was attended by 1159 registered
-
Indications, Techniques, and Barriers for Pancreas Transplant Biopsy: A Consensus Perspective From a Survey of US Centers. Transplantation (IF 6.2) Pub Date : 2024-03-12 Neeraj Singh, Krista L Lentine, Vidya A Fleetwood, Kenneth J Woodside, Jon Odorico, David Axelrod, Tarek Alhamad, Kennan Maher, Huiling Xiao, Jonathan Fridell, Aleksandra Kukla, Martha Pavlakis, Hosein M Shokouh-Amiri, Gazi Zibari, Matthew Cooper, Ronald F Parsons
Pancreas transplant biopsy practices for the diagnosis of rejection or other pathologies are not well described.
-
Targeting Macrophages in Organ Transplantation: A Step Toward Personalized Medicine. Transplantation (IF 6.2) Pub Date : 2024-03-12 Macee C Owen, Benjamin J Kopecky
Organ transplantation remains the most optimal strategy for patients with end-stage organ failure. However, prevailing methods of immunosuppression are marred by adverse side effects, and allograft rejection remains common. It is imperative to identify and comprehensively characterize the cell types involved in allograft rejection, and develop therapies with greater specificity. There is increasing
-
Sequential Normothermic Regional Perfusion and End-ischemic Ex Situ Machine Perfusion Allow the Safe Use of Very Old DCD Donors in Liver Transplantation. Transplantation (IF 6.2) Pub Date : 2024-03-12 Francesco Torri, Emanuele Balzano, Fabio Melandro, Paolo Maremmani, Pietro Bertini, Paolo Lo Pane, Matilde Masini, Maria Isabella Rotondo, Serena Babboni, Serena Del Turco, Stefano Antonelli, Vincenzo De Tata, Giandomenico Biancofiore, Fabio Guarracino, Aldo Paolicchi, Paolo De Simone, Giuseppina Basta, Davide Ghinolfi
In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory death (cDCD) liver transplantation by combining normothermic regional and end-ischemic machine perfusion (MP). The aim of this study was to evaluate the safety and feasibility of the use
-
Application of Mass Cytometry Platforms to Solid Organ Transplantation. Transplantation (IF 6.2) Pub Date : 2024-03-12 Wenming Zhang, Ayantika Sen, Josselyn K Pena, Andrea Reitsma, Oliver C Alexander, Tetsuya Tajima, Olivia M Martinez, Sheri M Krams
Transplantation serves as the cornerstone of treatment for patients with end-stage organ disease. The prevalence of complications, such as allograft rejection, infection, and malignancies, underscores the need to dissect the complex interactions of the immune system at the single-cell level. In this review, we discuss studies using mass cytometry or cytometry by time-of-flight, a cutting-edge technology
-
Impact of Hemoglobin Level in Ex Vivo Heart Perfusion on Donation After Circulatory Death Hearts: A Juvenile Porcine Experimental Model. Transplantation (IF 6.2) Pub Date : 2024-03-06 Yasuyuki Kobayashi, Jing Li, Marlee Parker, Jian Wang, Anita Nagy, Chun-Po Steve Fan, Kyle Runeckles, Michiru Okumura, Sachiko Kadowaki, Osami Honjo
Ex vivo heart perfusion (EVHP) of donation after circulatory death (DCD) hearts has become an effective strategy in adults; however, the small circulating volume in pediatrics poses the challenge of a low-hemoglobin (Hb) perfusate. We aimed to determine the impact of perfusate Hb levels during EVHP on DCD hearts using a juvenile porcine model.
-
First-in-human Study With LIS1, a Next-generation Porcine Low Immunogenicity Antilymphocyte Immunoglobulin in Kidney Transplantation. Transplantation (IF 6.2) Pub Date : 2024-02-29 Ondrej Viklicky, Janka Slatinska, Libor Janousek, Juliette Rousse, Pierre-Joseph Royer, Pierre-Louis Toutain, Emanuele Cozzi, Cesare Galli, Gwenaelle Evanno, Odile Duvaux, Jean-Marie Bach, Jean-Paul Soulillou, Magali Giral, Bernard Vanhove, Gilles Blancho
Polyclonal rabbit antithymocyte globulins (ATGs) are commonly used in organ transplantation as induction. Anti-N-glycolylneuraminic acid carbohydrate antibodies which develop in response to rabbit carbohydrate antigens might lead to unwanted systemic inflammation. LIS1, the first new generation of antilymphocyte globulins (ALGs) derived from double knockout swine, lacking carbohydrate xenoantigens
-
Basiliximab Induction and Postoperative Steroid-free Immunosuppression With Tacrolimus in Pediatric Liver Transplantation: A Randomized Clinical Trial. Transplantation (IF 6.2) Pub Date : 2024-02-29 Chong Dong, Zhuolun Song, Chao Sun, Kai Wang, Wei Zhang, Jing Chen, Weiping Zheng, Yang Yang, Zhen Wang, Chao Han, Lijun Jiao, Guofeng Zhang, Enbo Xie, Wei Gao, Zhongyang Shen
Optimizing the immunosuppressive regimen is essential to improve the long-term outcomes of pediatric liver transplant recipients.
-
Localized Liver Injury During Normothermic Ex Situ Liver Perfusion Has No Impact on Short-term Liver Transplant Outcomes. Transplantation (IF 6.2) Pub Date : 2024-02-29 Jack L Martin, Freya Rhodes, Sara Upponi, Yagazie Udeaja, Lisa Swift, Corina Fear, Rachel Webster, Gwilym James Webb, Michael Allison, Anna Paterson, Rohit Gaurav, Andrew J Butler, Christopher J E Watson
Normothermic ex situ liver perfusion (NESLiP) has the potential to increase organ utilization. Radiological evidence of localized liver injury due to compression at the time of NESLiP, termed cradle compression, is a recognized phenomenon but is poorly characterized.
-
Invasive Fungal Infections in Inpatient Solid Organ Transplant Recipients With COVID-19: A Multicenter Retrospective Cohort. Transplantation (IF 6.2) Pub Date : 2024-02-29 Nitipong Permpalung, Teresa Po-Yu Chiang, Kasama Manothummetha, Darin Ostrander, Kausik Datta, Dorry L Segev, Christine M Durand, Heba H Mostafa, Sean X Zhang, Allan B Massie, Kieren A Marr, Robin K Avery
The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood.
-
Pediatric Cardiac Xenotransplantation: Recommendations for the Ethical Design of Clinical Trials. Transplantation (IF 6.2) Pub Date : 2024-02-29 Daniel J Hurst, Luz Padilla, Anthony Merlocco, Daniel Rodger, Christopher Bobier, William H Gray, Robert Sorabella, David K C Cooper, Richard N Pierson
For children with complex congenital heart problems, cardiac allotransplantation is sometimes the best therapeutic option. However, availability of hearts for pediatric patients is limited, resulting in a long and growing waitlist, and a high mortality rate while waiting. Cardiac xenotransplantation has been proposed as one therapeutic alternative for neonates and infants, either in lieu of allotransplantation
-
Disparities in Liver Transplantation for Nonalcoholic Steatohepatitis in Women. Transplantation (IF 6.2) Pub Date : 2024-02-29 Erica C Becker, Osama Siddique, David M O'Sullivan, Wasim Dar, Michael Einstein, Glyn Morgan, Bishoy Emmanuel, Eva U Sotil, Elizabeth Richardson, Oscar K Serrano
Nonalcoholic steatohepatitis (NASH) is the fastest-growing indication for liver transplantation (LT). Sex disparities among patients with cirrhosis on the LT waitlist are well known. We wanted to understand these disparities further in women with end-stage liver disease patients listed for NASH cirrhosis in a contemporary cohort.
-
Transmission and Non-transmission of Melanoma From Deceased Solid Organ Donors to Transplant Recipients: Risks and Missed Opportunities. Transplantation (IF 6.2) Pub Date : 2024-02-29 Brenda Maria Rosales, James Hedley, Nicole De La Mata, Elena Cavazzoni, Claire M Vajdic, John F Thompson, Patrick J Kelly, Kate Wyburn, Angela C Webster
Biovigilance concerns are in tension with the need to increase organ donation. Cancer transmission risk from donor to recipient may be overestimated, as non-transmission events are rarely reported. We sought to estimate melanoma transmission risk in deceased organ donation and identify missed opportunities for donation in an Australian cohort with high melanoma prevalence.
-
Lung Progenitor and Stem Cell Transplantation as a Potential Regenerative Therapy for Lung Diseases. Transplantation (IF 6.2) Pub Date : 2024-02-28 Vanessa Serna Villa, Xi Ren
Chronic lung diseases are debilitating illnesses ranking among the top causes of death globally. Currently, clinically available therapeutic options capable of curing chronic lung diseases are limited to lung transplantation, which is hindered by donor organ shortage. This highlights the urgent need for alternative strategies to repair damaged lung tissues. Stem cell transplantation has emerged as
-
Twenty-four-hour Normothermic Ex Vivo Heart Perfusion With Low Flow Functional Assessment in an Adult Porcine Model. Transplantation (IF 6.2) Pub Date : 2024-02-27 Brianna L Spencer, Spencer K Wilhelm, Kristopher A Urrea, Vikramjit Chakrabortty, Sebastian Sewera, Daniel E Mazur, Joseph B Niman, Robert H Bartlett, Alvaro Rojas-Peña, Daniel H Drake
Cold static storage and normothermic ex vivo heart perfusion are routinely limited to 6 h. This report describes intermittent left atrial (LA) perfusion that allows cardiac functional assessment in a working heart mode.
-
Bile Chemistry During Ex Situ Normothermic Liver Perfusion Does Not Always Predict Cholangiopathy. Transplantation (IF 6.2) Pub Date : 2024-02-27 Christopher J E Watson, Rohit Gaurav, Lisa Swift, Corrina Fear, Michael E D Allison, Sara S Upponi, Rebecca Brais, Andrew J Butler
Bile chemistry during normothermic ex situ liver perfusion (NESLiP) has been suggested to be an indicator of cholangiopathy. The normal range of biochemical variables in bile of livers undergoing NESLiP has not been defined, nor have published biliary viability criteria been assessed against instances of posttransplant nonanastomotic bile strictures (NASs).
-
What Are Risk Factors for Graft Loss in Patients Who Underwent Simultaneous Splenectomy During Living-donor Liver Transplantation? Transplantation (IF 6.2) Pub Date : 2024-02-27 Takeo Toshima, Noboru Harada, Shinji Itoh, Takahiro Tomiyama, Katsuya Toshida, Kazutoyo Morita, Yoshihiro Nagao, Takeshi Kurihara, Takahiro Tomino, Yukiko Kosai-Fujimoto, Koshi Mimori, Tomoharu Yoshizumi
The consensus that portal venous pressure modulation, including splenectomy (Spx), prevents portal hypertension-related complications after living-donor liver transplantation (LDLT) has been established. However, little evidence about the risk factors for graft loss after simultaneous Spx during LDLT is available. This study aimed to identify the independent predictors of graft loss after simultaneous
-
Improved Waitlist Outcomes in Liver Transplant Patients With Mid-MELD-Na Scores Listed in Centers Receptive to Use of Organs Donated After Circulatory Death. Transplantation (IF 6.2) Pub Date : 2024-02-27 Katsunori Miyake, Lucy C Chau, Sheri Trudeau, Toshihiro Kitajima, Niluka Wickramaratne, Shingo Shimada, Ahmed Nassar, Humberto C Gonzalez, Deepak Venkat, Dilip Moonka, Atsushi Yoshida, Marwan S Abouljoud, Shunji Nagai
Liver transplant (LT) using organs donated after circulatory death (DCD) has been increasing in the United States. We investigated whether transplant centers' receptiveness to use of DCD organs impacted patient outcomes.
-
Serum Extracellular Vesicle Protein Profiling for Prediction of Corneal Transplant Rejection. Transplantation (IF 6.2) Pub Date : 2024-02-27 Hyun Ju Lee, Eun-Hye Bae, Jong Min Choi, Hyemee Kim, Hyeon Ji Kim, Heather Barreda, Sung Yun Jung, Joo Youn Oh, Ryang Hwa Lee
Corneal transplantation is the most common transplant procedure worldwide. Despite immune and angiogenic privilege of the cornea, 50% to 70% of corneal transplants fail in high-risk recipients, primarily because of immune rejection. Therefore, it is crucial to identify predictive biomarkers of rejection to improve transplant survival.
-
The Lower Survival in Patients With Alcoholism and Hepatitis C Continues in the DAA Era. Transplantation (IF 6.2) Pub Date : 2024-02-23 Paul J Thuluvath, Waseem Amjad, Jose Russe-Russe, Feng Li
Alcohol liver disease (ALD) may coexist with hepatitis C (HCV) in many transplant recipients (alcoholic cirrhosis with hepatitis C [AHC]). Our objective was to determine whether there were differences in postliver transplantation outcomes of patients with AHC when compared with those with alcoholic cirrhosis (AC) and/or alcoholic hepatitis (AH).
-
B Cell-mediated Immune Regulation and the Quest for Transplantation Tolerance. Transplantation (IF 6.2) Pub Date : 2024-02-23 Laurie Baert, Hasan Md Mahmudul, Mark Stegall, HyeMee Joo, SangKon Oh
Pathophysiologic function of B cells in graft rejection has been well recognized in transplantation. B cells promote alloantigen-specific T-cell response and secrete antibodies that can cause antibody-mediated graft failures and rejections. Therefore, strategies targeting B cells, for example, B-cell depletion, have been used for the prevention of both acute and chronic rejections. Interestingly, however
-
Transplantation in the Context of Migration and Refugees: A Summary of the DICG and TTS Ethics Committee Workshop, Buenos Aires, Argentina, September 2022. Transplantation (IF 6.2) Pub Date : 2024-02-22 Peter G Stock, Sanjay Nagral, Eric Rondeau, Sylwia Gawronska, Jennifer Groverman, Antoine Barbari, P Toby Coates, Beatriz Domínguez-Gil, Riadh Fadhil, Jolanta Malyszko, Alejandro Niño Murcia
Global conflicts and humanitarian crises have resulted in an unprecedented number of refugees and migrants. This challenges the limited resources of health care systems and jeopardizes the availability of transplant care for these deserving migrants and refugees. This was the basis for a workshop held during the Congress of the Transplantation Society (Buenos Aires, 2022). We elaborate on the proceedings
-
Use of Transesophageal Echocardiography for Liver Transplantation: A Global Comparison of Practice From the ILTS, SATA, and LICAGE. Transplantation (IF 6.2) Pub Date : 2024-02-22 Dmitri Bezinover, Jeron Zerillo, Ryan M Chadha, Gebhard Wagener, Annabel Blasi, Taylor Johnson, Terry Ling Te Pan, Lorenzo De Marchi
Anesthesiologists frequently use intraoperative transesophageal echocardiography (TEE) to aid in the diagnosis and management of hemodynamic problems during liver transplantation (LT). Although the use of TEE in US centers continues to increase, data regarding international use are lacking.
-
Histopathological Features and Role of Allograft Kidney Biopsy Among Recipients With Prolonged Delayed Graft Function: A Review. Transplantation (IF 6.2) Pub Date : 2024-02-22 Kurtis J Swanson, Weixiong Zhong, Didier A Mandelbrot, Sandesh Parajuli
Delayed graft function (DGF) is an early posttransplant complication predictive of adverse outcomes. This "acute kidney injury of transplantation" is often defined as allograft dysfunction requiring renal replacement within 7 d posttransplantation. DGF is an important area of study because it is emerging with efforts to expand the donor pool and address the supply-demand gap in kidney transplantation
-
Analysis of >15 000 Solid Organ Transplant Recipients Reveals Nonanal Genitourinary HPV-related Disease as Highest Risk Predictor for Anal Squamous Intraepithelial Lesions/Anal Cancer. Transplantation (IF 6.2) Pub Date : 2024-02-22 Matthew J Freeman, Qiuyu Yang, Linda Cherney-Stafford, Rob Striker, David P Foley, David P Al-Adra, Cristina B Sanger
Solid organ transplantation is a risk predictor for virally-mediated anal squamous intraepithelial lesions and cancer (anal disease). Precancerous squamous intraepithelial lesions can be detected by screening, and treatment may prevent cancer progression. Screening recommendations are not well defined. We aim to define prevalence and describe risk predictors for anal disease in a large population of
-
Spliced CEACAM1: A Potential Novel Biomarker and Target for Ameliorating Liver Ischemia-reperfusion Injury. Transplantation (IF 6.2) Pub Date : 2024-02-21 Hamza O Yazdani, David A Geller, Samer Tohme
Hepatic ischemia-reperfusion injury remains a significant challenge in liver transplantation potentially leading to delayed graft function, primary nonfunction, and sometimes rejection. Understanding the underlying mechanisms and implementing mitigation strategies are essential for improving transplant outcomes and patient survival. A recent study published by Dery et al shows that alternative splicing
-
Organ Nonutilization Following Revision to the Public Health Service Donor Risk Criteria for HIV, HCV, or HBV Transmission. Transplantation (IF 6.2) Pub Date : 2024-02-16 Suhani S Patel, Jacqueline I Kim, Darren E Stewart, Dorry L Segev, Allan B Massie
Organs from Public Health Service criteria (PHSC) donors, previously referred to as PHS infectious-risk donors, have historically been recovered but not used, traditionally referred to as "discard," at higher rates despite negligible risk to recipients. On March 1, 2021, the definition of PHSC donors narrowed to include only the subset of donors deemed to have meaningfully elevated risk in the current
-
The Promise of Complement Therapeutics in Solid Organ Transplantation. Transplantation (IF 6.2) Pub Date : 2024-02-16 Justin A Steggerda, Peter S Heeger
Transplantation is the ideal therapy for end-stage organ failure, but outcomes for all transplant organs are suboptimal, underscoring the need to develop novel approaches to improve graft survival and function. The complement system, traditionally considered a component of innate immunity, is now known to broadly control inflammation and crucially contribute to induction and function of adaptive T-cell
-
Negative Vaccination Strategies for Promotion of Transplant Tolerance. Transplantation (IF 6.2) Pub Date : 2024-02-16 Matthew J Tunbridge, Xunrong Luo, Angus W Thomson
Organ transplantation requires the use of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and fail to induce immunological tolerance to the graft. The safe induction of tolerance to allogeneic tissue without compromising host responses to infection or enhancing the risk of malignant disease is a major goal in transplantation. One promising approach to achieve
-
Marginal Zone B Cells Are Necessary for the Formation of Antidonor IgG After Allogeneic Sensitization. Transplantation (IF 6.2) Pub Date : 2024-02-16 Melissa A Kallarakal, Gregory S Cohen, Francis I Ibukun, Scott M Krummey
The formation of anti-major histocompatibility complex (MHC) antibodies is a significant barrier for many patients awaiting organ transplantation. Patients with preformed anti-MHC antibodies have limited options for suitable donors, and the formation of donor-specific anti-MHC antibodies after transplantation is a harbinger of graft rejection. Despite the recognized importance of anti-MHC antibodies
-
Kidney Transplantation Outcomes From Uncontrolled Donation After Circulatory Death: A Systematic Review and Meta-analysis. Transplantation (IF 6.2) Pub Date : 2024-02-16 Keshini Vijayan, Hugh J Schroder, Ahmer Hameed, Kerry Hitos, Warren Lo, Jerome M Laurence, Peter D Yoon, Christopher Nahm, Wai H Lim, Taina Lee, Lawrence Yuen, Germaine Wong, Henry Pleass
Uncontrolled donation after circulatory death (uDCD) is a potential additional source of donor kidneys. This study reviewed uDCD kidney transplant outcomes to determine if these are comparable to controlled donation after circulatory death (cDCD).
-
Pharmacomicrobiomics: Immunosuppressive Drugs and Microbiome Interactions in Transplantation. Transplantation (IF 6.2) Pub Date : 2024-02-16 Moataz E Mohamed, Abdelrahman Saqr, Christopher Staley, Guillaume Onyeaghala, Levi Teigen, Casey R Dorr, Rory P Remmel, Weihua Guan, William S Oetting, Arthur J Matas, Ajay K Israni, Pamala A Jacobson
The human microbiome is associated with human health and disease. Exogenous compounds, including pharmaceutical products, are also known to be affected by the microbiome, and this discovery has led to the field of pharmacomicobiomics. The microbiome can also alter drug pharmacokinetics and pharmacodynamics, possibly resulting in side effects, toxicities, and unanticipated disease response. Microbiome-mediated
-
Delayed Graft Function and the Renin-Angiotensin System. Transplantation (IF 6.2) Pub Date : 2024-02-16 Fatmah Yamani, Cosimo Cianfarini, Daniel Batlle
Delayed graft function (DGF) is a form of acute kidney injury (AKI) and a common complication following kidney transplantation. It adversely influences patient outcomes increases the financial burden of transplantation, and currently, no specific treatments are available. In developing this form of AKI, activation of the renin-angiotensin system (RAS) has been proposed to play an important role. In
-
Glucagon-like Peptide 1 Receptor Agonists and Cardiovascular Outcomes in Solid Organ Transplant Recipients With Diabetes Mellitus. Transplantation (IF 6.2) Pub Date : 2024-02-16 Idit Dotan, Yaron Rudman, Adi Turjeman, Amit Akirov, Tali Steinmetz, Bronya Calvarysky, Talia Diker Cohen
Glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce cardiovascular events and mortality in type 2 diabetes. Limited data are available on diabetes treatment after solid organ transplantation. We aimed to explore the effect of GLP1-RAs on cardiovascular outcomes in transplanted recipients with diabetes.
-
Identification of Antibodies to DQβ:DRα Interisotypic Heterodimers in Human Sera. Transplantation (IF 6.2) Pub Date : 2024-02-02 Thoa Nong, Nengjen Remi Shih, Robert A Bray, Mayra Lopez-Cepero, Cathi Murphey, Peter W Nickerson, Jar-How Lee
HLA class II antigens, DR, DQ, and DP, comprised an α and β chains, which typically combine, within the same isotype, to form the major histocompatibility complex:peptide complex. Interisotypic pairing is not commonly observed. Although reports of DQβ:DRα heterodimers exist, the pairing was reported to be unstable and, therefore, not studied to any extent.
-
Impact of Acute Exacerbation of Idiopathic Pulmonary Fibrosis on Lung Transplant Outcomes. Transplantation (IF 6.2) Pub Date : 2024-01-31 Krishnan Warrior, Karen Sayad, Christopher P O'Hara, Daniel F Dilling
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are acute, significant respiratory deteriorations in patients with IPF and can lead to increased morbidity and mortality. It remains unclear how AE-IPF impacts lung transplant (LTX) outcomes.
-
Association of Serum Osteoprotegerin With Vascular Calcification, and Cardiovascular and Graft Outcomes in Kidney Transplant Patients: Results From the KNOW-KT. Transplantation (IF 6.2) Pub Date : 2024-01-31 Hee Jung Jeon, Jung-Hwa Ryu, Myung-Gyu Kim, Kyu Ha Huh, Kyo Won Lee, Chan-Duck Kim, Kyung Pyo Kang, Han Ro, Seungyeup Han, Jaeseok Yang
Vascular calcification and stiffness contribute to increased cardiovascular morbidity in patients with chronic kidney disease. This study investigated associations between serum osteoprotegerin (OPG) levels and vascular calcification or stiffness to assess cardiovascular and graft outcomes in kidney transplant patients.
-
RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated With Acute T Cell-mediated Rejection. Transplantation (IF 6.2) Pub Date : 2024-01-31 Franco B Mueller, Hua Yang, Carol Li, Darshana M Dadhania, Jenny Z Xiang, Steven P Salvatore, Surya V Seshan, Vijay K Sharma, Manikkam Suthanthiran, Thangamani Muthukumar
Delineation of T-cell genes, gene sets, pathways, and T-cell subtypes associated with acute T cell-mediated rejection (TCMR) may improve its management.
-
COVID-19 Reinfection Has Better Outcomes Than the First Infection in Solid Organ Transplant Recipients. Transplantation (IF 6.2) Pub Date : 2024-01-31 Javier T Solera, Berta G Árbol, Ankit Mittal, Victoria G Hall, Tina Marinelli, Ilona Bahinskaya, Atul Humar, Deepali Kumar
Solid organ transplant recipients face an increased risk of severe coronavirus disease 2019 (COVID-19) and are vulnerable to repeat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. In nonimmunocompromised individuals, SARS-CoV-2 reinfections are milder likely because of cross-protective immunity. We sought to determine whether SARS-CoV-2 reinfection exhibits milder manifestations
-
A Multinational Cohort Study Examining Sex Differences in Excess Risk of Death With Graft Function After Kidney Transplant. Transplantation (IF 6.2) Pub Date : 2024-01-26 Amanda Jean Vinson, Xun Zhang, Mourad Dahhou, Caner Süsal, Bernd Döhler, Ruth Sapir-Pichhadze, Heloise Cardinal, Anette Melk, Germaine Wong, Anna Francis, Helen Pilmore, Bethany J Foster
Kidney transplant recipients show sex differences in excess overall mortality risk that vary by donor sex and recipient age. However, whether the excess risk of death with graft function (DWGF) differs by recipient sex is unknown.
-
The Impact of the Donor Card Holder Prioritization Program on Kidney Allocation in Israel. Transplantation (IF 6.2) Pub Date : 2024-01-26 Eytan Mor, Meitar Bloom, Ronen Ghinea, Roi Anteby, Ronit Pasvolsky-Gutman, Ron Loewenthal, Ido Nachmani, Tammy Hod
Since 2014, as part of a priority program within the Israeli Transplant Law, additional points were given to waitlisted candidates with donor cards. We assessed the impact on deceased donor kidney allocation.
-
Low-Dose Interleukin-2 Therapy: Fine-tuning Treg in Solid Organ Transplantation? Transplantation (IF 6.2) Pub Date : 2024-01-23 Leila Amini, Jaspal Kaeda, Olaf Weber, Petra Reinke
Regulatory T cells (Treg), a subset of CD4+ T cells, are potent regulators of immune reactions, which have been shown to be a promising therapeutic alternative to toxic immunosuppressive drugs. Data support the utility of Treg in managing immunopathologies, including solid organ transplant rejection, graft-versus-host disease, and autoimmune disorders. Notably, reports suggest that interleukin-2 (IL-2)
-
Caveats in Interpretation of Molecular Diagnostics in Heart Allografts. Transplantation (IF 6.2) Pub Date : 2024-01-23 Parmjeet S Randhawa
Histologic separation of injury, T cell-mediated rejection, or antibody-mediated rejection in allograft heart biopsies is difficult. A critical review of publications was performed to evaluate the caveats of using molecular diagnostics (MDX) to distinguish between these entities. Typically, only 1 to 2 fragments of unknown histologic appearance are evaluated. Archetype and molecular classifier analyses
-
Three-dimensional Liver Model Application for Liver Transplantation. Transplantation (IF 6.2) Pub Date : 2024-01-19 Jorge Sanchez-Garcia, Fidel Lopez-Verdugo, Rami Shorti, Jake Krong, Zachary J Kastenberg, Shannon Walters, Andrew Gagnon, Philippe Paci, Ivan Zendejas, Diane Alonso, Shiro Fujita, Alan G Contreras, Jean Botha, Carlos O Esquivel, Manuel I Rodriguez-Davalos
Children are removed from the liver transplant waitlist because of death or progressive illness. Size mismatch accounts for 30% of organ refusal. This study aimed to demonstrate that 3-dimensional (3D) technology is a feasible and accurate adjunct to organ allocation and living donor selection process.
-
Mismatched Postsurgical Opioid Prescription to Liver Transplant Patients: A Retrospective Cohort Study From a Single High-volume Transplant Center. Transplantation (IF 6.2) Pub Date : 2024-01-19 Victoria J Chen, Lucy S Guan, Michael P Bokoch, Erica Langnas, Rishi Kothari, Rhiannon Croci, Liam J Campbell, David Quan, Chris Freise, Zhonghui Guan
Improper opioid prescription after surgery is a well-documented iatrogenic contributor to the current opioid epidemic in North America. In fact, opioids are known to be overprescribed to liver transplant patients, and liver transplant patients with high doses or prolonged postsurgical opioid use have higher risks of graft failure and death.
-
The American Society of Transplant Surgeons Consensus Statement on Normothermic Regional Perfusion. Transplantation (IF 6.2) Pub Date : 2024-01-19 Anji E Wall, Bradley L Adams, Aleah Brubaker, Cherylee W J Chang, Kristopher P Croome, Jennifer Frontera, Elisa Gordon, Jordan Hoffman, Lewis J Kaplan, Deepali Kumar, Josh Levisky, Eduardo Miñambres, Brendan Parent, Christopher Watson, Ajmal Zemmar, Elizabeth A Pomfret
On June 3, 2023, the American Society of Transplant Surgeons convened a meeting in San Diego, California to (1) develop a consensus statement with supporting data on the ethical tenets of thoracoabdominal normothermic regional perfusion (NRP) and abdominal NRP; (2) provide guidelines for the standards of practice that should govern thoracoabdominal NRP and abdominal NRP; and (3) develop and implement
-
MEK1/2-PKM2 Pathway Modulates the Immunometabolic Reprogramming of Proinflammatory Allograft-Infiltrating Macrophages During Heart Transplant Rejection. Transplantation (IF 6.2) Pub Date : 2024-01-19 Zhang Chen, Yuan Li, Yuqing Niu, Xi Zhang, Jizhang Yu, Jikai Cui, Shuan Ran, Song Wang, Weicong Ye, Jiahong Xia, Jie Wu
Emerging evidence has highlighted the role of macrophages in heart transplant rejection (HTR). However, the molecular signals modulating the immunometabolic phenotype of allograft-infiltrating macrophages (AIMs) during HTR remain unknown.
-
Long-term Effects of Kidney Transplantation Compared With Dialysis on Intima-media Thickness in Children-Results From the 4C-T Study. Transplantation (IF 6.2) Pub Date : 2024-01-16 Carl Grabitz, Rizky I Sugianto, Anke Doyon, Karolis Azukaitis, Ali Anarat, Justine Bacchetta, Aysun K Bayazit, Ipek K Bulut, Salim Caliskan, Nur Canpolat, Ali Duzova, Jerome Harambat, Aysel Kiyak, Germana Longo, Lukasz Obrycki, Dusan Paripovic, Daniela Thurn-Valsassina, Alev Yilmaz, Rukshana Shroff, Franz Schaefer, Bernhard M W Schmidt, Anette Melk
Children requiring kidney replacement therapy experience high burden of cardiovascular (CV) disease leading to increased mortality. Intima-media thickness (IMT) indicating atherosclerosis is a validated surrogate marker for future CV events.
-
Clinical Research in Renal Transplantation: A Bibliometric Perspective on a Half-century of Innovation and Progress. Transplantation (IF 6.2) Pub Date : 2024-01-10 Decan Jiang, Anna Mantas, Alexander Studier-Fischer, Juri Fuchs, Deniz Uluk, Martin Loos, Markus Mieth, Martin Zeier, Peri Husen, Mohammad Golriz, Christoph Kahlert, Eduard Ryschich, Arianeb Mehrabi, Johann Pratschke, Christoph W Michalski, Zoltan Czigany
Groundbreaking biomedical research has transformed renal transplantation (RT) into a widespread clinical procedure that represents the mainstay of treatment for end-stage kidney failure today. Here, we aimed to provide a comprehensive bibliometric perspective on the last half-century of innovation in clinical RT.
-
Potential and Uncertainties of RejectClass in Acute Kidney Graft Dysfunction: An Independent Validation Study. Transplantation (IF 6.2) Pub Date : 2024-01-10 Friedrich A von Samson-Himmelstjerna, Nassim Kakavand, Charlotte Gleske, Florian Schraml, Agathe A Basta, Matthias C Braunisch, Jan H Bräsen, Jessica Schmitz, Daniel Kraus, Julia Weinmann-Menke, Helena U Zacharias, Thibaut Vaulet, Maarten Naesens, Markus Krautter, Vedat Schwenger, Grit Esser, Benedikt Kolbrink, Kerstin Amann, Christopher Holzmann-Littig, Fabian Echterdiek, Ulrich Kunzendorf, Lutz Renders
Kidney graft rejections are classified based on the Banff classification. The RejectClass algorithm, initially derived from a cohort comprising mostly protocol biopsies, identifies data-driven phenotypes of acute rejection and chronic pathology using Banff lesion scores. It also provides composite scores for inflammation activity and chronicity. This study independently evaluates the performance of
-
Infection and Prophylaxis During Normothermic Liver Perfusion: Audit of Incidence and Pharmacokinetics of Antimicrobial Therapy. Transplantation (IF 6.2) Pub Date : 2024-01-10 Saeed Qureshi, Heather Elliott, Alan Noel, Lisa Swift, Corrina Fear, Rachel Webster, Nicholas M Brown, Rohit Gaurav, Andrew J Butler, Christopher J E Watson
Ex situ normothermic liver perfusion (NMP) in a blood-based perfusate is associated with a risk of microbe growth, resulting in life-threatening posttransplant sepsis. Antibiotics are widely used, but the pharmacokinetics of these agents are unknown as is their efficacy. We wished to assess the perfusate concentrations of the meropenem and fluconazole that we use and to audit the incidence of infection
-
Optimization of Kidney Health in Liver Transplant Candidates: Pretransplant Considerations and Modalities. Transplantation (IF 6.2) Pub Date : 2024-01-09 Muhammad Y Jan, Kavish R Patidar, Marwan S Ghabril, Chandrashekhar A Kubal
Patients with decompensated end-stage liver disease (ESLD) are at increased risk for mortality, and only liver transplantation (LT) offers meaningful hope for survival. These patients are at risk for kidney dysfunction through the continuum of care for ESLD including LT. We discuss the role of accurate estimation and measurement of baseline glomerular filtration rate in assessment of kidney dysfunction
-
Impact of Prevascularization on Immunological Environment and Early Engraftment in Subcutaneous Islet Transplantation. Transplantation (IF 6.2) Pub Date : 2024-01-09 Kenta Inoguchi, Takayuki Anazawa, Nanae Fujimoto, Seiichiro Tada, Kei Yamane, Norio Emoto, Aya Izuwa, Hang Su, Hiroyuki Fujimoto, Takaaki Murakami, Kazuyuki Nagai, Etsuro Hatano
The utilization of islet-like cells derived from pluripotent stem cells may resolve the scarcity of islet transplantation donors. The subcutaneous space is a promising transplantation site because of its capacity for graft observation and removal, thereby ensuring safety. To guarantee subcutaneous islet transplantation, physicians should ensure ample blood supply. Numerous methodologies, including
-
No Evidence of Progressive Proinflammatory Cytokine Storm in Brain-dead Organ Donors-A Time-course Analysis Using Clinical Samples. Transplantation (IF 6.2) Pub Date : 2024-01-09 Katarzyna D Bera, Joel Tabak, Rutger J Ploeg
Solid organ transplantation is a cost-effective treatment for end-stage organ failure. Organ donation after brain death is an important source of transplanted organs. Data are limited on the effects of brain injury or donor management on grafts. The consensus view has been that brain death creates a progressively proinflammatory environment. We aimed to investigate time-course changes across a range
-
Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States. Transplantation (IF 6.2) Pub Date : 2023-12-27 Patrick T Gauthier, Katelynn S Madill-Thomsen, Zachary Demko, Adam Prewett, Philippe Gauthier, Philip F Halloran
Among all biopsies in the Trifecta-Kidney Study (ClinicalTrials.gov NCT04239703), elevated plasma donor-derived cell-free DNA (dd-cfDNA) correlated most strongly with molecular antibody-mediated rejection (AMR) but was also elevated in other states: T cell-mediated rejection (TCMR), acute kidney injury (AKI), and some apparently normal biopsies. The present study aimed to define the molecular correlates
-
Incidence of Acute Rejection Compared With Endomyocardial Biopsy Complications for Heart Transplant Patients in the Contemporary Era. Transplantation (IF 6.2) Pub Date : 2023-12-15 Vincenzo Cusi, Florin Vaida, Nicholas Wettersten, Nicholas Rodgers, Yuko Tada, Bryn Gerding, Marcus Anthony Urey, Barry Greenberg, Eric D Adler, Paul J Kim
The reference standard of detecting acute rejection (AR) in adult heart transplant (HTx) patients is an endomyocardial biopsy (EMB). The majority of EMBs are performed in asymptomatic patients. However, the incidence of treated AR compared with EMB complications has not been compared in the contemporary era (2010-current).
-
Effectiveness of a Fourth COVID-19 mRNA Vaccine Dose Against the Omicron Variant in Solid Organ Transplant Recipients. Transplantation (IF 6.2) Pub Date : 2023-12-13 Kyla L Naylor, Gregory A Knoll, Graham Smith, Eric McArthur, Jeffrey C Kwong, Stephanie N Dixon, Darin Treleaven, S Joseph Kim
The effectiveness of booster doses of COVID-19 vaccines in solid organ transplant recipients is unclear. We conducted a population-based matched cohort study using linked administrative healthcare databases from Ontario, Canada to estimate the marginal vaccine effectiveness of a fourth versus third dose of the BNT162b2 and mRNA-1273 vaccines against clinically important outcomes (ie, hospitalization
-
Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation-A Retrospective Multicenter Outcome Analysis. Transplantation (IF 6.2) Pub Date : 2023-12-11 Volker Assfalg, Gregor Miller, Felix Stocker, Norbert Hüser, Daniel Hartmann, Uwe Heemann, Ineke Tieken, Wouter Zanen, Serge Vogelaar, Alexander R Rosenkranz, Stefan Schneeberger, Reinhold Függer, Gabriela Berlakovich, Dirk R Ysebaert, Daniel Jacobs-Tulleneers-Thevissen, Dimitri Mikhalski, Steven van Laecke, Dirk Kuypers, Anja S Mühlfeld, Richard Viebahn, Johann Pratschke, Sebastian Melchior, Ingeborg
Whenever the kidney standard allocation (SA) algorithms according to the Eurotransplant (ET) Kidney Allocation System or the Eurotransplant Senior Program fail, rescue allocation (RA) is initiated. There are 2 procedurally different modes of RA: recipient oriented extended allocation (REAL) and competitive rescue allocation (CRA). The objective of this study was to evaluate the association of patient
-
Later Brain Death Declaration Correlates to Favorable Donor Characteristics but Decreased Heart Acceptance. Transplantation (IF 6.2) Pub Date : 2023-12-08 Jason W Greenberg, Eashwar C Kantemneni, Kevin Kulshrestha, Jessica S Clothier, Mallika V Desai, David S Winlaw, Farhan Zafar, David L S Morales
With rates of potential donor heart discard as high as 66% nationally, quality improvement efforts must seek to optimize donor utilization. Whether the timing of donor brain death declaration (BDD) influences organ acceptance is understudied. The authors sought to characterize the impacts of time between donor hospital admission and BDD on heart utilization and posttransplant outcomes.
-
High Number of Plasma Exchanges Increases the Risk of Bacterial Infection in ABO-incompatible Living Donor Liver Transplantation. Transplantation (IF 6.2) Pub Date : 2023-12-07 Mun Chae Choi, Eun-Ki Min, Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim
Bacterial infections are major complications that cause significant mortality and morbidity in living donor liver transplantation (LDLT). The risk of bacterial infection has not been studied in ABO-incompatible (ABOi) recipients with a desensitization protocol in relation to the number of plasma exchanges (PEs). Therefore, we aimed to analyze the risk of bacterial infection in ABOi LDLT recipients