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Early ambulation after fibular free flap surgery is associated with reduced length of stay, increased mobility independence, and discharge to home Head Neck (IF 2.9) Pub Date : 2024-03-18 Hilary C. McCrary, Mitchell F. Dunklebarger, Brett J. Fechter, Sarah M. Drejet, Marcus M. Monroe, Luke O. Buchmann, Jason P. Hunt, Richard B. Cannon
Fibula free flaps (FFF) are one of the most common bony flaps utilized. This paper describes a quality improvement project aimed at increasing early ambulation.
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Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta-analysis Head Neck (IF 2.9) Pub Date : 2024-03-18 Sagar Kansara, Evrim Oral, Indrani Sarkar, Vlad Sandulache, Rula Mualla, Rohan R. Walvekar, William Ryan, Patrick Ha
The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer.
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EGFR overexpression and macrophage infiltration correlate with poorer prognosis in HPV-negative oropharyngeal cancer via STAT6 signaling Head Neck (IF 2.9) Pub Date : 2024-03-18 Huai-Pao Lee, Chia-Jung Li, Ching-Chih Lee
The prevalence of HPV-negative oropharyngeal cancer (OPC) is higher in Asian countries. Patients with HPV-negative OPC suffer poor outcomes. Multi-omics analysis could provide researchers and clinicians with more treatment targets for this high-risk group. We aimed to explore the prognostic significance of EGFR overexpression and macrophage infiltration in OPC, especially HPV-negative OPC in this study
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Durvalumab in combination with chemoradiotherapy in patients with head and neck squamous cell carcinoma: Results from the Phase 1 CLOVER study Head Neck (IF 2.9) Pub Date : 2024-03-17 Julie E. Bauman, Sana D. Karam, Cathy O'Brien, Gabriel Mak, Byoung Chul Cho
The Phase 1 CLOVER study (NCT03509012) assessed durvalumab in combination with concurrent chemoradiotherapy (cCRT) in patients with advanced solid tumors; we report results from the head and neck squamous cell carcinoma (HNSCC) cohort.
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Intelligent method to predict intensive care unit admission after drainage operation in patients with deep neck space abscess: A multicenter retrospective study Head Neck (IF 2.9) Pub Date : 2024-03-16 Han Lei, Yu Lin, Weixiong Chen, Tianrun Liu, Jin Ye, Qian Cai, Fei Ye, Long He, Xingqiang Xie, Guoping Xiong, Wenxiang Gao, Wenbin Lei
BackgroundsA deep neck space abscess (DNSA) is a critical condition resulting from infection of deep neck fascia and soft issue, leading to high morbidity and mortality. Therefore, intensive care can be very significant for patients with DNSA. This study aimed to develop models to predict the need for postoperative intensive care in patients with DNSA.MethodsWe retrospectively analyzed the records
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Online ratings and narrative comments of American Head and Neck Society surgeons Head Neck (IF 2.9) Pub Date : 2024-03-16 Joshua K. Kim, Karen Tawk, Jonathan M. Kim, Hady Shahbaz, Joshua A. Lipton, Yarah M. Haidar, Tjoson Tjoa, Mehdi Abouzari
BackgroundWe analyzed online rating scores and comments of head and neck surgeons to understand factors that contribute to higher ratings.MethodsNumerical ratings and comments for American Head and Neck Society physicians were extracted from Healthgrades, Vitals, RateMDs, and Yelp, with narrative comments categorized based on content. Physician practice location, education, and residency training were
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Evaluation of the safety and effectiveness of robot‐assisted neck dissections Head Neck (IF 2.9) Pub Date : 2024-03-16 Vusala Snyder, Brandon Smith, Seungwon Kim, Matthew E. Spector, Umamaheswar Duvvuri
BackgroundRobot‐assisted neck dissection (RAND) for the management of the regional lymphatic basin offers the potential for improved cosmesis and reduced lymphedema. While RAND has been previously described, functional outcome and oncologic control rates need further elucidation.MethodsA retrospective, matched cohort study of neck dissections completed at UPMC from 2017 to 2021 was conducted. RAND
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Neoadjuvant therapy to improve resectability of advanced thyroid cancer: A real‐world experience Head Neck (IF 2.9) Pub Date : 2024-03-16 Marika Russell, Matti L. Gild, Lori J. Wirth, Bruce Robinson, Amanda Silver Karcioglu, Ayaka Iwata, Tejas S. Athni, Amr H. Abdelhamid Ahmed, Gregory W. Randolph
BackgroundExperience with targeted neoadjuvant treatment for locoregionally advanced thyroid cancer is nascent.MethodsMulticenter retrospective case series examining targeted neoadjuvant treatment for locoregionally advanced thyroid cancer. The primary outcome was change in surgical morbidity as measured by two metrics developed for use in clinical trials to characterize surgical complexity and morbidity
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MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma Head Neck (IF 2.9) Pub Date : 2024-03-14 Talita de Carvalho Kimura, João Figueira Scarini, Luccas Lavareze, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho‐Camillo, Ana Cristina Victorino Krepischi, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
ObjectiveThis study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).Materials and MethodsWe analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs
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Treatment discordance in the utilization of neck dissection for stage I‐II supraglottic tumors Head Neck (IF 2.9) Pub Date : 2024-03-14 Shivee Gilja, Vikram Vasan, Arvind Kumar, Scott A. Roof, Eric M. Genden, Diana N. Kirke
BackgroundIn 2018, the National Comprehensive Cancer Network treatment guidelines began recommending the use of neck dissection during surgical management of stage I‐II supraglottic laryngeal squamous cell carcinoma (LSCC).MethodsTrends and factors associated with the use of neck dissection during larynx‐preserving surgery for patients with cT1‐2, N0, M0 supraglottic LSCC in the National Cancer Database
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Sexual history of patients with human papillomavirus positive and negative oropharyngeal cancer: A systematic review and meta‐analysis Head Neck (IF 2.9) Pub Date : 2024-03-13 Frederick G. Durrant, Jorge A. Gutierrez, Shaun A. Nguyen, Cherie‐Ann O. Nathan, Jason G. Newman
BackgroundIncreased sexual activity is associated with higher human papillomavirus (HPV) rates; however, there is a lack of analysis comparing the sexual history of patients with HPV positive and HPV negative oropharyngeal cancer (OPC).MethodsIn this meta‐analysis, PubMed, Scopus, and CINAHL were searched for articles that included patients with OPC and reported information regarding HPV status and
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Pattern of regional recurrence after selective neck dissection for clinically positive neck in mucosal squamous carcinoma Head Neck (IF 2.9) Pub Date : 2024-03-13 Mohammad Altawil, Isabella Stanisz, Nadia H. Van Den Berg, Patrick Sheahan
BackgroundSelective neck dissection (SND) has traditionally been applied to clinically negative (cN0) necks in mucosal squamous cell carcinoma (SCC). We aimed to examine the oncological safety and patterns of regional recurrence (RR) of SND in clinically positive (cN+) necks.MethodsRetrospective review of prospective cohort of 206 patients with mucosal SCC undergoing neck dissection. RR was classified
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Survival and complications after carotid resection for head and neck squamous cell carcinoma: A systematic review and pooled analysis Head Neck (IF 2.9) Pub Date : 2024-03-12 Gian Marco Pace, Carolina Morales‐Olavarría, Andrea Costantino, Bianca Maria Festa, Elena Russo, Giannicola Iannella, Claudio Carnevale, Pasquale Di Maio, Claudio Sampieri, Remo Accorona, Armando De Virgilio
ObjectiveThe aim of this study is to analyze oncologic outcomes and complications rate after common or internal carotid artery (CCA/ICA) resection for head and neck squamous cell carcinoma (HNSCC).MethodsThis study was conducted in conformity with the PRISMA statement. A systematic review and pooled analysis was performed for overall survival (OS), disease specific survival (DSS) (primary outcomes)
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Subcutaneous implantation of nodular goiter after transoral endoscopic thyroidectomy vestibular approach: A case study and review of literature Head Neck (IF 2.9) Pub Date : 2024-03-12 Yu‐Jing Weng, Kristine J. S. Kwan, De‐Biao Chen, Ben‐ling Hu, Jiang Jiang, Lei Min, Qing Ai, Wei‐chun Chen, Zhi‐Heng Huang
BackgroundExtrathyroid implantation or dissemination of thyroid tissue secondary to a thyroid procedure is rare. Most of these belonged to thyroid carcinoma with metastatic potential and uncommon for benign pathologies.MethodsWe report the case of a 31‐year‐old female who was identified to have multiple subcutaneous implantation of thyroid tissue 5 years after transoral endoscopic thyroidectomy vestibular
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Free vascularized fibula leads to hallux toe flexion deformity due to ischemic muscle contracture of flexor hallucis longus Head Neck (IF 2.9) Pub Date : 2024-03-12 Hao Wu, Yuehao Hu, Zilin Wang, Yige Liu, Jing Han, Chenping Zhang, Zanjing Zhai, Jiannan Liu
BackgroundThis study aimed to investigate the incidence of toe flexion deformity after fibular free flap transplantation and to analyze the etiology of the deformity.MethodsFifty patients underwent vascularized fibular free flap transplantation were retrospectively included. Statistical analysis examined correlations between deformity occurrence and resected fibula length and residual distal fibula
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Anterior endoscopic sublabial transmaxillary access to middle cranial base lesions Head Neck (IF 2.9) Pub Date : 2024-03-11 Azin Tabari, Sevil Nasirmohtaram, Hassan Reza Mohammadi, Mehdi Zeinalizadeh, Seyed Mousa Sadrehosseini
BackgroundAnterior endoscopic access to middle cranial base lesions becomes feasible in the presence of infratemporal fossa (ITF) involvement. Various approaches, including endoscopic endonasal, transoral sublabial, and transorbital methods, have been described for accessing the ITF through a transmaxillary corridor. Among these approaches, endonasal access is the most commonly preferred, while the
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Drainless, day‐case lateral neck dissection with Artiss™ fibrin sealant: A prospective cohort study Head Neck (IF 2.9) Pub Date : 2024-03-11 Ayla Tabaksert, Tobias James, Christopher Rusius, Holt Walters, Shane Lester
ObjectiveLateral neck dissection (LND) is performed for staging/treatment of head and neck lesions. This traditionally includes placement of a drain and inpatient admission. Drainless, day‐case head and neck surgery is attractive due to cost‐effectiveness and reduced length of stay, but evidence is lacking in LND. We aim to investigate Artiss™ as an alternative to drain placement, facilitating day‐case
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Optimizing presurgical education for patients with head and neck cancer receiving laryngectomy and free flap surgery: A qualitative study Head Neck (IF 2.9) Pub Date : 2024-03-09 Marian Mikhael, Bhargav Kansara, Ameer Basta, Emma Hume, Oliver T. Nguyen, Maija Reblin, Young‐Rock Hong, Amir Alishahi Tabriz, Krupal Patel, Jeffery Scott Magnuson, Kea Turner
BackgroundThere has been limited study of oncology professionals' perspectives on optimizing delivery of presurgical education for individuals with head and neck cancer (HNC). Therefore, we assessed oncology professionals' perspectives about presurgical education for laryngectomy and free flap surgeries, which have a significant impact on patients' quality of life.MethodsInterviews were conducted with
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The tumor microenvironment of benign and malignant salivary gland tumors Head Neck (IF 2.9) Pub Date : 2024-03-08 Katherine C. Wai, Trine Line H. Okholm, Patrick K. Ha, Diana M. Marquez, Iliana Tenvooren, Kyle B. Jones, Matthew H. Spitzer
BackgroundTreatment of salivary gland tumors (SGTs) remains challenging. Little is known about the immune landscape of SGTs. We aimed to characterize the tumor microenvironment in benign and malignant SGTs.MethodsEleven benign and nine malignant tumors were collected from patients undergoing curative intent surgery. Specimens were analyzed using mass cytometry by time‐of‐flight. Immune cell populations
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Improving detection of oral lesions: Eye tracking insights from a randomized controlled trial comparing standardized to conventional approach Head Neck (IF 2.9) Pub Date : 2024-03-08 Behrus Puladi, Beatrice Coldewey, Julia S. Volmerg, Kim Grunert, Jeff Berens, Ashkan Rashad, Frank Hölzle, Rainer Röhrig, Myriam Lipprandt
BackgroundEarly detection of oral cancer (OC) or its precursors is the most effective measure to improve outcome. The reasons for missing them on conventional oral examination (COE) or possible countermeasures are still unclear.MethodsIn this randomized controlled trial, we investigated the effects of standardized oral examination (SOE) compared to COE. 49 dentists, specialists, and dental students
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Combined simultaneous endoscopic endonasal and transcranial surgery using high‐definition three‐dimensional exoscope for malignant tumors of the anterior skull base Head Neck (IF 2.9) Pub Date : 2024-03-07 Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando
BackgroundAdvanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high‐definition three‐dimensional exoscope as an alternative to traditional microscopy.MethodsSix patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver
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Postoperative inpatient surgical complications following head and neck microvascular free tissue transfer Head Neck (IF 2.9) Pub Date : 2024-03-06 Hasan Abdulbaki, Patrick K. Ha, Philip D. Knott, Andrea M. Park, Rahul Seth, Chase M. Heaton, Katherine C. Wai
BackgroundComplications following head and neck microvascular free tissue transfer (MFTT) are common. Less is known about when they occur.MethodRetrospective study of patients with primary or recurrent head and neck cancer undergoing MFTT reconstruction at a tertiary care institution. MFTT reconstructions with inpatient postoperative complications were included. The Kruskal–Wallis test was used to
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Characterization of the tumor microenvironment in the mouse oral cancer (MOC1) model after orthotopic implantation in the buccal mucosa Head Neck (IF 2.9) Pub Date : 2024-03-06 Vikash Kansal, Brendan L. C. Kinney, Nicole C. Schmitt
BackgroundPreclinical models are invaluable for studies of head and neck cancer. There is growing interest in the use of orthotopic syngeneic models, wherein cell lines are injected into the oral cavity of immunocompetent mice. In this brief report, we describe injection of mouse oral cancer 1 (MOC1) cells into the buccal mucosa and illustrate the tumor growth pattern, lymph node response, and changes
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External beam radiation therapy for recurrent or residual thyroid cancer: What is the best treatment time and the best candidate for long‐term local disease control? Head Neck (IF 2.9) Pub Date : 2024-03-06 Lara Bessa Campelo Pinheiro Cavalcante, Natalia Treistman, Fabiola Maria Teresa Torres Gonzalez, Pollyanna Iemini Weyll Fernandes, Paulo Alonso Garcia Alves Junior, Fernanda Accioly Andrade, Elisa Napolitano Ferreira, Tarcisio Fontenele De Brito, Attilio Pane, Rossana Corbo, Felipe Erlich, Daniel Alves Bulzico, Fernanda Vaisman
IntroductionCervical disease control might be challenging in advanced thyroid cancer (DTC). Indications for cervical external beam radiation therapy (EBRT) are controversial.PurposeTo identify clinical and molecular factors associated with control of cervical disease with EBRT.MethodsRetrospective evaluation and molecular analysis of the primary tumor DTC patients who underwent cervical EBRT between
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Diagnostic value of water swallow test for dysphagia in patients with head and neck cancer: A systematic review and meta‐analysis Head Neck (IF 2.9) Pub Date : 2024-03-06 Yu Zhang, Yiqiao Wang, Yu Zhu, Hongwei Wan
The diagnostic efficacy of the water swallow test (WST) is relatively robust for patients with neurogenic dysphagia; however, its diagnostic performance in identifying dysphagia among patients with HNC varies across studies. Our study aims to assess the diagnostic value of the WST for detecting dysphagia in patients with HNC. Systematic retrieval of studies on the use of WST for screening dysphagia
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Prognostic value of bone marrow and tumor 18F‐FDG uptake on PET/CT in patients with oropharyngeal cancer and the interplay between inflammation and FDG uptake Head Neck (IF 2.9) Pub Date : 2024-03-05 Constantina Nadia Christou, Karl Sandström, Naresh Regula, Ylva Tiblom Ehrsson, Hemming Johansson, Jens Sörensen, Göran Laurell
AimsTo examine the prognostic value of F‐18 fluorodeoxyglucose (FDG) uptake in the bone marrow (BM) for disease recurrence and survival in patients with oropharyngeal squamous cell carcinoma (OP‐SCC). The secondary aims were to evaluate the prognostic value of PET/CT parameters for the primary oropharyngeal tumor and total tumor burden, and to assess the correlation between FDG uptake variables and
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Accurate preoperative prediction of nodal metastasis in papillary thyroid microcarcinoma: Towards optimal management of patients Head Neck (IF 2.9) Pub Date : 2024-03-05 Si‐Ying Lin, Meng‐Yao Li, Chi‐Peng Zhou, Wei Ao, Wen‐Yu Huang, Si‐Si Wang, Jia‐Fan Yu, Zi‐Han Tang, Amr H. Abdelhamid Ahmed, Ting‐Yi Wang, Zhi‐hong Wang, Surong Hua, Gregory W. Randolph, Wen‐Xin Zhao, Bo Wang
ObjectiveTo enhance the accuracy in predicting lymph node metastasis (LNM) preoperatively in patients with papillary thyroid microcarcinoma (PTMC), refining the “low‐risk” classification for tailored treatment strategies.MethodsThis study involves the development and validation of a predictive model using a cohort of 1004 patients with PTMC undergoing thyroidectomy along with central neck dissection
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Establishment of an in situ model to explore the tumor immune microenvironment in head and neck squamous cell carcinoma Head Neck (IF 2.9) Pub Date : 2024-03-04 Congxian Lu, Yuteng Yang, Mingjun Zhang, Jiaxuan Li, Hao Song, Hongfei Zhao, Yakui Mou, Yumei Li, Xicheng Song
ObjectiveEstablish an in situ model for investigating HNSCC, focusing on tumor growth, metastasis, and the immune microenvironment.MethodsGenerated a monoclonal SCCVII‐ZsGreen cell line through lentiviral transfection. Selected monoclonal lines with growth rates similar to the original SCCVII for in vivo tumorigenesis. Monitored tumor development and metastasis through fluorescence in vivo imaging
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Weekly assessment of volumetric and dosimetric changes during volumetric modulated arc therapy of locally advanced head and neck carcinoma: Implications for adaptive radiation therapy—A prospective study Head Neck (IF 2.9) Pub Date : 2024-03-04 Aathira T. Sreejeev, Deepa Joseph, Ajay S. Krishnan, Rajesh Pasricha, Sweety Gupta, Rachit Ahuja, Nidhi Sharma, Debanjan Sikdar, Sagar Raut, Abhijith Sasi, Manoj Gupta
BackgroundChemoradiation in head and neck carcinoma (HNC) shows significant anatomical resulting in erroneous dose deposition in the target or the organ at risk (OAR). Adaptive radiotherapy (ART) can overcome this. Timing of significant target and OAR changes with dosimetric impact; thus, most suitable time and frequency of ART is unclear.MethodsThis dosimetric study used prospective weekly non‐contrast
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The impact of COVID‐19 and vaccination status on outcomes in veterans with head and neck squamous cell carcinoma Head Neck (IF 2.9) Pub Date : 2024-03-04 James D. Johns, Erica J. Choe, Paul F. Chisolm, Morgan J. Pothast, Jackson R. Randolph, Jiling Chou, Jessica H. Maxwell
BackgroundThe impact of both COVID‐19 infection and vaccination status on patients with head and neck squamous cell carcinoma (HNSCC) remains unknown.ObjectiveTo determine the impact of COVID‐19 infection and vaccination status on 60‐day mortality, cardiovascular, and respiratory complications in patients with a prior diagnosis of HNSCC.MethodsThis was a retrospective cohort study through the Veterans
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The effect of carbon nanoparticles vs. immune colloidal gold technique test strips on parathyroid protection in total thyroidectomy: A randomized clinical trial study Head Neck (IF 2.9) Pub Date : 2024-03-01 Bochun Wang, Yiyuan Zhu, Shiguo Zhou, Cheng Lu, Aobo Zhang, Jun Tian, Wanxin Li, Shuling Ren, Yanbo Dong, Liangfa Liu
The long-term effect of intraoperative usage of carbon nanoparticles (CN) and parathyroid hormone (PTH) test strip using immune colloidal gold technique (ICGT) is unclear. This study aims to compare the effect of intraoperative usage of CN and ICGT test strips on PG function.
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Differential modulation of PI3K/Akt/mTOR activity by EGFR inhibitors: A rationale for co‐targeting EGFR and PI3K in cisplatin‐resistant HNSCC Head Neck (IF 2.9) Pub Date : 2024-03-02 Jipei Liao, Zejia Yang, Shirin Abarzarzin, Kevin J. Cullen, Hancai Dan
PurposeTo find a new strategy to treat cisplatin‐resistant head and neck squamous cell carcinoma (HNSCC), we investigated the effects of EGFR inhibitors on the PI3K/Akt/mTOR pathway and determined the efficacy of EGFR inhibitors in combination with PI3K inhibitors to suppress cell proliferation in cisplatin‐resistant‐HNSCC.MethodsThe cisplatin‐resistant HNSCC cell lines were treated with four FDA approved
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Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment Head Neck (IF 2.9) Pub Date : 2024-03-01 Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata
BackgroundThe pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis.MethodsReconstruction was performed based on the classification of the defects. Clinical details were
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Reliability and outcomes of lymph nodes biopsy in cT1–cT2 N0 supraglottic laryngeal squamous cell carcinoma Head Neck (IF 2.9) Pub Date : 2024-02-29 Maryline Hoste, Sébastien Van der Vorst, Georges Lawson, Marie‐Cécile Nollevaux, Anne‐Sophie Pirson, Vincent Bachy, Olivier Desgain, Samantha Hassid, Gilles Delahaut
BackgroundIn oral and oropharyngeal squamous cell carcinoma (SCC), sentinel node biopsy (SNB) was described as a reliable and reproductive alternative to elective neck dissection for the staging of clinical N0 T1–T2 patients. The SNB technique in supraglottic laryngeal SCC was successfully described in small series. The aim of this study is to analyze retrospectively the results of SNB technique in
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Free flap jaw reconstruction with dental implantation: A single‐institution experience Head Neck (IF 2.9) Pub Date : 2024-02-29 Benjamin T. Ostrander, Leo Meller, Matthew Harmon, Katya Archambault, Thanos Kristallis, Daniel Hammer, Ryan K. Orosco
BackgroundWe sought to review our institution's experience with dental implant placement in free flap jaw reconstruction to determine factors impacting restoration of dental occlusion.MethodsExactly 48 patients underwent free flap jaw reconstruction with or without dental restoration from 2017 to 2022. Primary outcome was achievement of restored dental occlusion after jaw free flap reconstruction.ResultsA
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Post‐surgical readmission risk factors in otolaryngology/head and neck surgery Head Neck (IF 2.9) Pub Date : 2024-02-28 Jane Kwon, Douglas Farquhar, Jason Tasoulas, Trevor G. Hackman
BackgroundOtolaryngology patients are a high‐readmission‐risk group due to the complexity of surgeries, significant alterations to speech and swallowing functions, and high postoperative complications risk.MethodsA retrospective review was performed on patients who underwent otolaryngologic surgery at a single‐academic‐institution between March 2019 and February 2020.ResultsAmong 365 discharges, 21
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Early feeding after free flap reconstruction of the oral cavity: A systematic review and meta‐analysis Head Neck (IF 2.9) Pub Date : 2024-02-28 Joshua Barlow, Zara Sragi, Nina Rodriguez, Mathilda Alsen, Catharine Kappauf, Rocco Ferrandino, Susmita Chennareddy, Tamar Kotz, Diana N. Kirke, Marita S. Teng, Eric M. Genden, Mohemmed N. Khan, Scott A. Roof
BackgroundTraditionally, patients undergoing free flap reconstruction for oral cavity defects have been given nothing by mouth for 6–14 days post‐operatively due to concern for orocutaneous fistula development.MethodsMultiple databases were screened for studies assessing the rate of orocutaneous fistula formation in early (≤5 days) versus late (>5 days) feeding groups following oral cavity free flap
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Airway protection and outcomes after staged versus concurrent bilateral neck dissections with transoral base of tongue cancer resection Head Neck (IF 2.9) Pub Date : 2024-02-28 Jake J. Lee, Nicholas A. Rapoport, Patrik Pipkorn, Sidharth V. Puram, Ryan S. Jackson
ObjectivesTo assess airway, safety, and resource utilization outcomes between transoral base of tongue (BOT) surgery with staged versus concurrent bilateral neck dissections (BND).MethodsA retrospective cohort study of patients with human papilloma virus (HPV)‐related BOT cancer who underwent transoral surgery and BND from January 2015 through June 2022 was conducted. Free flap patients were excluded
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Prognostic risk factors of buccal squamous cell carcinoma: A case–control study Head Neck (IF 2.9) Pub Date : 2024-02-27 Jacquelyn K. Callander, Spenser S. Souza, Yasmin Eltawil, Ivan H. El‐Sayed, Jonathan R. George, Patrick Ha, William R. Ryan, Mary Jue Xu, Chase M. Heaton
ObjectivesTo describe the clinicopathologic presentation of buccal squamous cell carcinoma and identify risks factors for recurrence and overall survival.MethodsThis is a retrospective case–control study of patients with oral cavity squamous cell carcinoma (OCSCC) treated at a single tertiary care center between 2010 and 2022. All patients with buccal subsite OCSCC treated during this time frame were
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Salvage skull base surgery after proton beam therapy for recurrent sinonasal malignancies: A retrospective study Head Neck (IF 2.9) Pub Date : 2024-02-26 Shinichi Okada, Takashi Mukaigawa, Seiya Goto, Yohei Hiiragi, Fuyuki Sato, Shoichi Deguchi, Hirofumi Ogawa, Tsuyoshi Onoe, Shigeyuki Murayama, Yoshichika Yasunaga, Nakamasa Hayashi
BackgroundThis study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT).MethodsNine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed.ResultsThe cohort comprised four
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Postoperative pain management using an intravenous combination of ibuprofen and acetaminophen compared with acetaminophen alone after thyroidectomy: A prospective randomized controlled trial Head Neck (IF 2.9) Pub Date : 2024-02-26 Jaesik Park, Do Kyung Lee, Ji Eun Kim, Ja Seong Bae, Jeong‐Soo Kim, Yung Eun Moon
BackgroundMultiple medications are more effective than single agents for postoperative pain management. We investigated the analgesic effects of an intravenous combination of acetaminophen and ibuprofen immediately after thyroidectomy.MethodsIn this double‐blind clinical trial, 62 patients who underwent thyroidectomies were randomized to either the treatment (1000 mg acetaminophen, 300 mg ibuprofen)
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Oncocytic carcinoma of the thyroid: Conclusions from a 20‐year patient cohort Head Neck (IF 2.9) Pub Date : 2024-02-23 Nelson R. Gruszczynski, Shahzeb S. Hasan, Ana G. Brennan, Julian De La Chapa, Adithya S. Reddy, David N. Martin, Prem P. Batchala, Edward B. Stelow, Eric M. Dowling, Katherine L. Fedder, Jonathan C. Garneau, David C. Shonka
BackgroundOncocytic carcinoma (OCA) was recently reclassified as a distinct differentiated thyroid carcinoma (DTC). Given its rarity, OCA studies are limited. This study describes the characteristics of OCA in a 20‐year cohort.MethodsRetrospective analysis of patients with OCA at a single tertiary care hospital from 2000 to 2021.ResultsFifty‐one OCA patients (22M:29F) were identified. The mean age
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Immunotherapy targeting tumor‐associated antigen in a mouse model of head and neck cancer Head Neck (IF 2.9) Pub Date : 2024-02-23 Michihisa Kono, Risa Wakisaka, Hiroki Komatsuda, Ryusuke Hayashi, Takumi Kumai, Hidekiyo Yamaki, Ryosuke Sato, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Hiroya Kobayashi, Tatsuya Hayashi, Miki Takahara
BackgroundThe identification of epitope peptides from tumor‐associated antigens (TAAs) is informative for developing tumor‐specific immunotherapy. However, only a few epitopes have been detected in mouse TAAs of head and neck cancer (HNSCC).MethodsNovel mouse c‐Met‐derived T‐cell epitopes were predicted by computer‐based algorithms. Mouse HNSCC cell line‐bearing mice were treated with a c‐Met peptide
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Latissimus dorsi myocutaneous free flap for the laryngopharyngectomy defect Head Neck (IF 2.9) Pub Date : 2024-02-23 Corin M. Kinkhabwala, Julian Amin, Tyler Rist, Vilija J. Vaitaitis, Judith M. Skoner
BackgroundPartial or total laryngopharyngectomy defects have traditionally been reconstructed using the radial forearm, anterolateral thigh, or jejunal free flaps. The latissimus dorsi myocutaneous free flap (LDMFF) is an option for high‐risk patients with complex laryngopharyngeal ± cutaneous neck defects.MethodsRetrospective single‐surgeon case series from 2017 to 2022. Outcomes were assessed at
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Clinical outcomes of cetuximab‐based treatment for distant metastatic head and neck squamous cell carcinoma: A real‐world study using Taiwan Head Neck Society registry database Head Neck (IF 2.9) Pub Date : 2024-02-22 Hsueh‐Ju Lu, Meng‐Che Hsieh, Hung‐Ming Wang, Jason Chia‐Hsun Hsieh, Chia‐Jui Yen, Shang‐Yin Wu, Huai‐Cheng Huang, Hui‐Ching Wang, Pen‐Yuan Chu, Tien‐Hua Chen, Chih‐Yen Chien, Tai‐Lin Huang, Yi‐Fang Chang, Chun‐Hung Hua, Ming‐Yu Lien, Jo‐Pai Chen, Wei‐Chen Lu, Jin‐Ching Lin, Chen‐Chi Wang, Yi‐Chun Liu, Muh‐Hwa Yang, Pei‐Jen Lou
BackgroundFor R/M HNSCC, the differences in prognosis and treatment options between distant metastasis (DM) and locoregional recurrence, especially in the DM group, remain unclear.MethodsFrom the Taiwan Head Neck Society registry database, patients who were diagnosed with R/M HNSCC and received cetuximab‐based frontline therapy were collected for analysis.ResultsAmong the enrolled patients, 59.3% (491/827)
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Monoamine oxidase B inhibits epithelial‐mesenchymal transition and trigger apoptosis via targeting ERK1/2 signaling pathway in head and neck squamous cell carcinoma Head Neck (IF 2.9) Pub Date : 2024-02-21 Yibo Qi, Weihua Shao, Jing Gao, Nan Ni, Feifei Xue, Tianxiao Wang, Yuli Wang, Yi Fan, Hua Yuan
BackgroundMonoamine oxidase B (MAOB), a flavin monoamine oxidase, regulates biogenic and xenobiotic amine oxidative deaminization. We demonstrate MAOB expression in head and neck epithelium and its biological importance in head and neck squamous cell carcinoma (HNSCC) development.MethodsFirst, we found a possible MAOB downregulation in HNSCC using bioinformatic analysis. Second, we validated MAOB expression
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Development of a novel senescence‐related gene signature to predict clinical outcomes, immune landscape, and chemotherapeutic sensitivity in oral squamous cell carcinoma Head Neck (IF 2.9) Pub Date : 2024-02-21 An Wang, Na Xiao, Hong Wang, Qin Yao, Jin Li, Yaping Wu, Han Ge, Pengfei Diao
BackgroundCellular senescence significantly associates with tumor initiation, progression, and therapeutic response across multiple cancers. Here, we sought to develop a novel senescence‐related genes (SRGs)‐derived signature for oral squamous cell carcinoma (OSCC) prognostication and therapeutic response prediction.MethodsOSCC‐specific SRG prognostic signature was established with univariate Cox regression
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Development of a head and neck lymphoedema specific quality of life tool: The Comprehensive Assessment of Lymphoedema Impact in the Head and Neck Head Neck (IF 2.9) Pub Date : 2024-02-21 Heather M. Starmer, Joanne Patterson, Bridget Young, Jason Fleming, Mary Gemma Cherry
PurposeTo develop a head and neck lymphoedema (HNL) specific quality of life (QoL) instrument to assess physical, functional, and social/emotional impacts of HNL.MethodsInstrument candidate items were reviewed by patients with HNL and clinicians and rated for importance, clarity, and invasiveness. The Content Validity Ratio was applied for item reduction. Three‐step cognitive interviews were conducted
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Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments Head Neck (IF 2.9) Pub Date : 2024-02-21 Beatriz Febrero, Juan José Ruiz‐Manzanera, Inmaculada Ros‐Madrid, Antonio Miguel Hernández, Esteban Orenes‐Piñero, José Manuel Rodríguez
The tumor immune microenvironment of thyroid cancer is the heterogeneous histological space in which tumor cells coexist with host cells. Published data from this review were identified by search and selection database of Pubmed, Elsevier, and Science Direct. Searching was made in two steps using different keywords. In thyroid pathology, the inflammatory response is very important, and might have a
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Neoadjuvant chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in elderly patients with stage III-IVa nasopharyngeal carcinoma: A real-world study based on medical comorbidities Head Neck (IF 2.9) Pub Date : 2024-02-17 Ya-Nan Jin, Zhi-Wen Xiao, Wei Yao, Jing Yu, Wang-Jian Zhang, Tia Marks, Hong-Yu Zhang, Ji-Jin Yao, Liang-Ping Xia
To evaluate the outcomes and toxicities of adding neoadjuvant chemotherapy (NAC) to concurrent chemoradiotherapy (CCRT) in elderly (≥65 years) patients with locoregionally advanced nasopharyngeal carcinoma (LANPC, stage III-IVa).
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Effect of waiting time for radiotherapy after last induction chemotherapy on prognosis of locally advanced nasopharyngeal carcinoma Head Neck (IF 2.9) Pub Date : 2024-02-17 Kui-Xuan Zhu, Ting Ding, Yi-Min E, Hong-Wei Yang, Rui-Ping Wu, Run-Jia Liu, Ling-Li Zhou, Wen-Jie Fu, Mei-Ping Jiang, Xiao-Li Wang
The effect of radiotherapy waiting time after last induction chemotherapy (IC-RT) on prognosis of patients with locally advanced nasopharyngeal carcinoma (LANPC) needs further discussion.
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Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma Head Neck (IF 2.9) Pub Date : 2024-02-16 Cristina Riobello, Paula Sánchez-Fernández, María Camila Cubides Córdoba, Maripaz González-Gutiérrez, Blanca Vivanco, Virginia N. Cabal, Laura Suárez Fernández, Rocío García-Marín, Helena Codina-Martínez, Sara Lucila Lorenzo-Guerra, Fernando López, Mario A. Hermsen, José Luis Llorente
Recurrent intestinal-type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.
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Surgery for nonlocalizing hyperparathyroidism in high volume center Head Neck (IF 2.9) Pub Date : 2024-02-16 Austin B. Miller, Ethan Frank, Alfred A. Simental, Max Feng
Patients with nonlocalizing hyperparathyroidism pose a significant challenge to surgeons when undergoing neck exploration for parathyroidectomy.
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Retropharyngeal abscess due to Fusobacterium necrophorum complicated by progressive internal carotid artery stenosis and multiple cranial nerve palsies Head Neck (IF 2.9) Pub Date : 2024-02-20 Sohta Matsumura, Takeo Sato, Satoshi Matsushima, Tatsushi Kokubu, Tadashi Umehara, Teppei Komatsu, Kenichiro Sakai, Hidetaka Mitsumura, Yasuyuki Iguchi
BackgroundA case of retropharyngeal abscess complicated by both artery and nerve injury has rarely been reported.MethodsA 36‐year‐old woman suddenly presented with right eye visual loss, dilated pupil, reduced direct light reflex, ptosis and ocular motility disorder on the side of inflammation progression, and was diagnosed with retropharyngeal abscess due to Fusobacterium necrophorum. The patient
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Predicting reoperation and readmission for head and neck free flap patients using machine learning Head Neck (IF 2.9) Pub Date : 2024-02-15 Stephanie Y. Wang, Louis-Xavier Barrette, Jinggang J. Ng, Neel R. Sangal, Steven B. Cannady, Robert M. Brody, Andrés M. Bur, Jason A. Brant
To develop machine learning (ML) models predicting unplanned readmission and reoperation among patients undergoing free flap reconstruction for head and neck (HN) surgery.
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Sarcopenia predicts short-term treatment-related toxicity in patients undergoing curative-intent therapy for head and neck cancer: A systematic review and meta-analysis Head Neck (IF 2.9) Pub Date : 2024-02-14 Marco A. Mascarella, Jannatul Ferdus, Varun Vendra, Shaum Sridharan, Khalil Sultanem, Christina Tsien, George Shenouda, Nathaniel Bouganim, Khashayar Esfahani, Keith Richardson, Alex Mlynarek, Nader Sadeghi, Michael Hier, Marie-Jeanne Kergoat
Sarcopenia is an increasingly recognized biomarker associated with poorer outcomes. The objective of this study was to ascertain the effect of sarcopenia on treatment tolerance and short-term toxicity in head and neck cancer (HNC). A systematic review was performed using multiple databases. An inverse-variation, random-effects model was used to perform the meta-analysis to evaluate the effect of sarcopenia
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Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685 Head Neck (IF 2.9) Pub Date : 2024-02-14 Christopher S. Hollenbeak, Fenghai Duan, Rathan M. Subramaniam, Alexander Taurone, JoRean Sicks, Val J. Lowe, Brendan C. Stack
This study examined the trajectory of health-related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s).
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Electromyography findings in radiation-induced unilateral tongue immobility Head Neck (IF 2.9) Pub Date : 2024-02-14 Randall J. Harley, Jonas T. Johnson, Marci L. Nilsen, Michael C. Munin
We used electromyography to characterize hypoglossal nerve function among radiation-treated head and neck cancer survivors with later onset unilateral tongue immobility.
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Patient-reported outcome measures for dysphagia in head and neck cancer: A systematic review and appraisal of content validity and internal structure Head Neck (IF 2.9) Pub Date : 2024-02-15 Beatrice Manduchi, Zhiyao Che, Jolie G. Ringash, Margaret I. Fitch, Doris Howell, Rosemary Martino
Dysphagia is a major head and neck cancer (HNC) issue. Dysphagia-related patient-reported outcome measures (PROMs) are critical for patient-centred assessment and intervention tailoring. This systematic review aimed to derive a comprehensive inventory of HNC dysphagia PROMs and appraise their content validity and internal structure. Six electronic databases were searched to February 2023 for studies