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Statement of Retraction: Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats J. Invest. Surg. (IF 1.9) Pub Date : 2024-02-12
Published in Journal of Investigative Surgery (Vol. 37, No. 1, 2024)
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Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders J. Invest. Surg. (IF 1.9) Pub Date : 2024-02-07 Cassandra A. Cairns, Lan Xiao, Jian-Ying Wang
The human intestinal epithelium has an impressive ability to respond to insults and its homeostasis is maintained by well-regulated mechanisms under various pathophysiological conditions. Nonethele...
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Survival and Prognosis for Patients with Rectal Melanomas in the United States: A SEER-Based Study J. Invest. Surg. (IF 1.9) Pub Date : 2024-01-17 Fan Zhang, Boqi Xu, Yao Peng, Runda Wu, Shan Tong, Zhongqi Mao
Limited attention was paid to focus on rectal melanomas (RM). This study aimed to evaluate the survival rate and prognostic factors of RM.The data for patients with RM from Surveillance, Epidemiolo...
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The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma J. Invest. Surg. (IF 1.9) Pub Date : 2024-01-15 Yuan Wang, Hongguang Lian, Jiajun Li, Man Zhao, Zengfang Hao, Xue Zheng, Linyuan Zhao, Jinfeng Cui
Gene mutations in tumor cells can lead to several unique metabolic phenotypes, which are crucial for the proliferation of cancer cells. EGFR mutation (EGFR-mt) is the main oncogenic driving mutatio...
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Anterior, Posterior and Anterior–Posterior Approaches for the Treatment of Thoracolumbar Burst Fractures: A Network Meta-Analysis of Randomized Controlled Trials J. Invest. Surg. (IF 1.9) Pub Date : 2024-01-10 Yuchen Duan, Dagang Feng, Jun Chen, Yamei Wu, Tong Li, Leiming Jiang, Yong Huang
To compare the clinical and radiological results of the anterior approach versus the posterior approach versus the anterior–posterior approach for the treatment of thoracolumbar burst fractures.The...
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Effects of Mesalamine Combined with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules on Intestinal Mucosa Barrier Function and Intestinal Microbiota in Mildly Active Crohn’s Disease Patients J. Invest. Surg. (IF 1.9) Pub Date : 2023-12-30 Meiqin Shen, Yingqi Shi, Zhenming Ge, Junbo Qian
Objective: This study is aimed at investigating the impact of mesalamine combined with Live combined Bifidobacterium, Lactobacillus and Enterococcus capsules on intestinal mucosa barrier function a...
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Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis J. Invest. Surg. (IF 1.9) Pub Date : 2023-12-04 Qirun Cheng, Lipeng Chen, Liping Ni
This study aims to investigate the association between miR-203 expression and the prognostic value in patients with esophageal cancer by the method of systematic review and meta-analysis.We searche...
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Avoiding Excessive Physical Restraints to Reduce ICU Pseudo Delirium J. Invest. Surg. (IF 1.9) Pub Date : 2023-11-27 Taotao Liu
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Comparison of Intraoperative Endplate Injury between Mini-Open Lateral Lumbar Interbody Fusion (LLIF) and Transforaminal Lumbar Interbody Fusion (TLIF) and Analysis of Risk Factors: A Retrospective Study J. Invest. Surg. (IF 1.9) Pub Date : 2023-11-27 Xiaowei Jing, Zhiyuan Gong, Ning Zhang, Zhengkuan Xu, Xiaowen Qiu, Fangcai Li, Wei Liu, Qingfeng Hu, Qixin Chen
The study aimed to compare the incidence of intraoperative endplate injury in patients who underwent Transforaminal interbody fusion (TLIF) and mini-open lumbar interbody fusion (LLIF) surgery. The...
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Comparison between Endoscopic Submucosal Dissection and Transanal Endoscopic Microsurgery in Early Rectal Neuroendocrine Tumor Patients: A Meta-Analysis J. Invest. Surg. (IF 1.9) Pub Date : 2023-11-16 Fu-Gang Wang, Ying Jiang, Chao Liu, Hong Qi
To compare the effectiveness, safety and cost-effectiveness of endoscopic submucosal dissection (ESD) with transanal endoscopic microsurgery (TEM) in early rectal neuroendocrine tumor (RNET) patien...
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The Distinct Pattern of Granulomatous Lobular Mastitis with Erythema Nodosum: More Severe Conditions and Extensive Lesions J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-24 Bilian Zheng, Man Lu, Chuang Chen, Shengrong Sun
Granulomatous lobular mastitis (GLM) is a benign inflammatory disease of the mammary gland with unknown etiology. Erythema nodosum (EN) is a rare, extramammary symptom of GLM. The purpose of this a...
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Percutaneous Functional Spinal Unit Cementoplasty versus Posterior Spinal Fixation with Vertebroplasty for Symptomatic Chronic Osteoporotic Vertebral Fractures: A Retrospective Study with a 2-Year Follow up J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-18 Youdi Xue, Zhifa Lun, Jie Feng, Weixiang Dai
To compare the clinical efficacy of percutaneous functional spinal unit cementoplasty (PFSUP) and posterior spinal fixation combined with vertebroplasty (PSF + VP) for the treatment of symptomatic ...
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Mini-Review: Tendon-Exposed Wound Treatments J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-09 Zhuan Deng, Zhi-Sheng Long, Gang Chen
Tendon-exposed wounds are complex injuries with challenging reconstructions and no unified treatment mode. Furthermore, insufficient tissue volume and blood circulation disorders affect healing, wh...
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Novel Insights about Synergistic Effect of Zamzam Water with SGL2 Inhibitors on Wound Healing in STZ-Induced Diabetic Rats: The Role of anti-Inflammatory and Proangiogenic Effects J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-09 Medhat Taha, Sara T. Elazab, Ammar Qutub, Omer Abdelbagi, Tourki A. S. Baokbah, Gomaa S. Ahmed, Randa A. Zaghloul, Alaa Jameel A. Albarakati, Naeem F. Qusty, Omar Babateen, Abdullah G. Al-Kushi
Background: Hyperglycemia usually impairs wound healing by dysregulating the inflammatory response and angiogenesis. This study aimed to examine the synergistic effect of dapagliflozin and Zamzam w...
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Verteporfin Suppresses YAP-Induced Glycolysis in Breast Cancer Cells J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-12 Hong Chen, Ling-Fei Zhang, Ying Miao, Yun Xi, Xuefei Li, Mo-Fang Liu, Min Zhang, Biao Li
The inhibition of the Hippo pathway through targeting the Yes-associated protein (YAP) presents a novel and promising approach for treating tumors. However, the efficacy of YAP inhibitors in the co...
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Femoral Neck System versus Three Cannulated Screws for Fixation of Femoral Neck Fractures in Younger Patients: A Retrospective Cohort Study J. Invest. Surg. (IF 1.9) Pub Date : 2023-10-09 Shuang G. Yan, Yiliang Cui, Di Li, Fanxiao Liu, Xingyi Hua, Florian Schmidutz
To compare the clinical results of a new femoral neck system (FNS) and cannulated compression screws (CCS) for the treatment of femoral neck fractures in younger patients.Retrospective study was pe...
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Active Intra-Abdominal Drainage Following Abdominal Digestive System Surgery: A Meta-Analysis and Systematic Review J. Invest. Surg. (IF 1.9) Pub Date : 2023-09-21 Minghui Zheng, Ting Niu, Junfeng Peng, Ligang Shi, Chenghao Shao
Our objective is to compare the early outcomes associated with passive (gravity) drainage (PG) and active drainage (AD) after surgery.Studies published until April 28, 2022 were retrieved from the ...
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Neural Invasion is an Independent Prognostic Factor in Young and Lymph Node Negative Gastric Cancer Patients Underwent Curative Gastrectomy J. Invest. Surg. (IF 1.9) Pub Date : 2023-09-20 Linjun Wang, Yiwen Xia, Tianlu Jiang, Ying Li, Yikai Shen, Jie Lin, Fengyuan Li, Weizhi Wang, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu
The prognostic significance of neural invasion (NI) in gastric cancer (GC) has not been established. This study is to investigate the characteristic and prognostic value of NI in GC.592 patients wh...
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Outcomes of Holmium Laser, Cryoablation, and Budesonide Inhalation for Treating Severe Central Airway Stenosis in Infants J. Invest. Surg. (IF 1.9) Pub Date : 2023-09-21 Lei Zhang, Shuhua Yuan, Chunhong Pan, Jing Zhang, Jinhong Wu, Yong Yin
Central airway stenosis (CAS) in infants is characterized by dysphonia, dyspnea, cyanosis, repeated apnea, and infection. This case series study aimed to evaluate the safety and efficacy of holmium...
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S100 Calcium-Binding Protein A8 Functions as a Tumor-Promoting Factor in Renal Cell Carcinoma via Activating NF-κB Signaling Pathway J. Invest. Surg. (IF 1.9) Pub Date : 2023-08-01 Shu-Hui Wang, Yan-Jie Xia, Jing Yu, Chun-Yan He, Jie-Ru Han, Ji-Xiang Bai
Abstract Background Renal cell carcinoma (RCC), arising from the renal tubular epithelium, is one of the most common types of genitourinary malignancies. Based on the Gene Expression Omnibus (GEO) database (GSE100666), S100 calcium-binding protein A8 (S100A8) was highly expressed in RCC tissues. S100A8, an inflammatory regulatory factor, has emerged as an important mediator associated with the occurrence
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Expression of miR-425-5p in Pancreatic Carcinoma and Its Correlation with Tumor Immune Microenvironment J. Invest. Surg. (IF 1.9) Pub Date : 2023-07-16 Shuo Jian, Dehua Kong, Jieli Tian
Abstract Background: Pancreatic carcinoma (PC) is a global health threat with a high death rate. miRNAs are implicated in tumor initiation and progression. This study explored the expression of miR-425-5p in PC patients and its correlation with tumor immune microenvironment (TIME). Method: miR-425-5p expression in cancer tissues and adjacent non-tumor tissues of PC patients was examined by RT-qPCR
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Functional Mechanism of MicroRNA-25-3p in Hilar Cholangiocarcinoma Cell Proliferation and Migration Through Regulation of Dual Specificity Phosphatase 5 J. Invest. Surg. (IF 1.9) Pub Date : 2023-07-02 Wan Zhong, Shiyang Dong, Han Wang, Chao Pan, Shiyong Yang
Abstract Objective Hilar cholangiocarcinoma (HCCA) is a highly aggressive biliary tract tumor. microRNAs (miRs) exert dual actions in various cancers. This paper seeks to expound on the functional mechanisms of miR-25-3p/dual specificity phosphatase 5 (DUSP5) in HCCA cell proliferation and migration. Methods HCCA-related data were downloaded from GEO database to screen out differentially-expressed
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Calycosin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice through the miR-375-3p/ROCK2 Axis J. Invest. Surg. (IF 1.9) Pub Date : 2023-07-03 Jie Yao, Mingfeng Cheng, Fan Yang
Abstract Objective: Septic patients are especially vulnerable to acute lung injury (ALI). Calycosin (CAL) has various promising pharmacological activities. This paper aims to expound on the role of CAL in mice with sepsis-induced ALI and the associated mechanisms. Methods: Mouse models of sepsis-induced ALI were established using lipopolysaccharide (LPS). Pulmonary histopathological changes were observed
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Visual Observation of Abdominal Adhesion Progression Based on an Optimized Mouse Model of Postoperative Abdominal Adhesions J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-25 Zijun Wang, Enmeng Li, Cancan Zhou, Bolun Qu, Tianli Shen, Jie Lian, Gan Li, Yiwei Ren, Yunhua Wu, Qinhong Xu, Guangbing Wei, Xuqi Li
Abstract Background: There is no clear description of the evolution of the progression of abdominal adhesions over time. Method: The optimized model was selected using different adhesion scoring systems. Then, this model was used to observe the progression of abdominal adhesions. Visualized observation of abdominal adhesion evolution was performed by laparoscopy and computed tomography. The inflammatory
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Surgical Research Progress of Sentinel Lymph Node Biopsy in Melanoma J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-22 Haining Mou, Qian Tan
Abstract Malignant melanoma is a highly aggressive tumor, and lymph node metastasis significantly impacts the prognosis and treatment of this condition. Sentinel node biopsy, as a less invasive alternative to traditional dissection, offers convenience, safety, and improved efficiency in assessing local lymph node status. It provides valuable staging information and aids in determining appropriate follow-up
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Letter to the Editor: “Systemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis” J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-20 Justin S. Roskam, John M. Adams, Rolando H. Rolandelli, Louis T. Difazio, Patricia B. Stopper, Zoltan H. Nemeth
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Single-Incision Plus One Port Laparoscopic Surgery for Myomectomy: A Retrospective Study J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-19 Gaoli Niu, Hua Zhao, Hong Wang, Lingli Zhao, Yanhong Zhai
Abstract Background The purpose of this study was to evaluate the effect of single-incision plus one port laparoscopic surgery (SILS + 1) for myomectomy. Methods We retrospectively analyzed data from patients who underwent laparoendoscopic single-site myomectomy (LESS-M group, n = 40) and SILS + 1 (SILS + 1-M group, n = 40) for myomectomy at our hospital from October 2018 through December 2020. The
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circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-05 Fei Wang, Qian Ma, Xinglu Dong, Tinghuan Wang, Chao Ma
Abstract Cerebral ischemia-reperfusion (I/R) injury (CI/RI) is a severe problem in patients with cerebral ischemia. The current study explored the influences of circular (circ)-Gucy1a2 on neuronal apoptosis and mitochondrial membrane potential (MMP) in the brain tissue of CI/RI mice. Forty-eight mice were randomized into the sham group, transient middle cerebral artery occlusion (tMCAO) group, lentivirus
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Extended Ligation of the Hepatic Vein May Yield a Similar Effect to Liver Venous Deprivation in a Rat Model J. Invest. Surg. (IF 1.9) Pub Date : 2023-06-01 Xiaoqin He, Yuefeng Zhang, Gaoshuo Zhang, Peng Ma, Liangkun Xiong, Wei Wang, Yangtao Xu, Yang Shen, Kaihuan Yu, Weixing Wang
Abstract Aims To validate the hypothesis that hepatic vein ligation (HVL) alone may produce similar results to liver venous deprivation (LVD or HVL + portal vein ligation [PVL]). Methods Rats were assigned to five groups, namely, the control group; the R group in which the right median hepatic vein (RMHV) was ligated; the M group in which the middle median hepatic vein (MMHV) was ligated; the RM group
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SOX9 Inhibits the Progression of Osteonecrosis of the Femoral Head via the Activation of the Wnt/Beta-Catenin Pathway J. Invest. Surg. (IF 1.9) Pub Date : 2023-04-19 Xiangsheng Meng, Haiquan Zhu
Abstract Background: In this study, we aimed to explore whether the SRY-box transcription factor 9 (SOX9) can play protective roles against the occurrence and development of osteonecrosis of the femoral head (ONFH) by regulating the proliferation, apoptosis, and osteogenic differentiation of human bone marrow stromal cells (hBMSCs) via the Wnt/β-catenin pathway. Methods: We used 1600 mg of glucocorticoid
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Prognostic Value of Systemic Inflammation Score for Esophageal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis J. Invest. Surg. (IF 1.9) Pub Date : 2023-04-17 Lingfang Shi, Xiufang Wang, Chungen Yan
Abstract Objective The link between inflammation and cancer survival has been the subject of substantial research. The goal of this review is to summarize the evidence on the prognostic value of systemic inflammation score (SIS) in esophageal cancer patients undergoing surgical intervention. Methods PubMed, Scopus, Embase, and Web of Science were searched for relevant articles published until 30th
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Incidence, Prognostic Factors, and Survival of Patients with Renal Cancer: A Population-Based Study J. Invest. Surg. (IF 1.9) Pub Date : 2023-04-09 Bai-Shu Zheng, Shun-De Wang, Jun-Yong Zhang, Cheng-Guo Ge
Abstract Background The main objective of this article is to understand trends in the incidence of renal cancer and to construct a nomogram to predict the prognosis of patients with renal cancer by analyzing clinical parameters. Methods We extracted data from the Surveillance, Epidemiology and End Results (SEER) database for patients with renal cancer from 2010 to 2015. The incidence rate was calculated
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Utilization of Perifascial Loose Areolar Tissue Grafting as an Autologous Dermal Substitute in Extremity Burns J. Invest. Surg. (IF 1.9) Pub Date : 2023-04-02 Burak Özkan, Burak Ergün Tatar, Abbas Albayati, Cagri Ahmet Uysal
Abstract Background Perifascial areolar tissue (PAT) is an areolar layer over the muscle fascia. PAT has been shown to be resistant to ischemia and prone to survival even in ischemic conditions. PAT grafts provide a vascular tissue layer on necrotic bone and tendons where skin grafting is not possible. The effect of PAT grafting on burn reconstruction has not yet been reported. Thus, in this study
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The Effect of Antioxidant Astaxanthin on Intestinal Ischemia Reperfusion Damage in Rats J. Invest. Surg. (IF 1.9) Pub Date : 2023-03-05 Arda Sakir Yilmaz, Bartu Badak, Nilufer Erkasap, Mete Ozkurt, Ertugrul Colak
Mesenteric ischemia is a frequently encountered disease in surgical clinics, difficult to diagnose, and very mortal if not treated. Our study investigated the effects of astaxanthin, which is known...
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Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis J. Invest. Surg. (IF 1.9) Pub Date : 2023-02-12 Wei-Sheng Chen, Ze-Xin Huang, Hui-Hui Zhang, Xiao-Dong Chen, Yi-Qi Cai, Wen-Jing Chen, Guan-Bao Zhu, Yun-Shi Huang
Abstract Purpose Readmission is one of the measures of quality of care and potential costs. This study aimed to determine whether lactate dehydrogenase (LDH) is associated with an increased risk of 30-day readmission in gastric cancer. Methods We performed a retrospective study of patients who underwent radical gastrectomy for gastric cancer at our institution between July 2014 and May 2018. Balanced
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Effect of Negative Pressure Wound Therapy on Surgical Site Infections following Stoma Reversal in Colorectal Surgery: A Meta-Analysis J. Invest. Surg. (IF 1.9) Pub Date : 2023-02-05 Junjia Zhu, Qi Sun, Wenlong Xu, Jun Geng, Qiang Feng, Zhenguo Zhao, Sen Li
Surgical site infections (SSI) are common complications after surgery, which cause other complications and increase medical costs. However, the effect of negative-pressure wound therapy (NPWT) for ...
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Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation J. Invest. Surg. (IF 1.9) Pub Date : 2023-01-18 Hongying Li, Yuqin Yuan, Hong Dong, Tinghui Wang, Dunlan Zhang, Limin Zhou, Lu Chen, Xueyan He
Abstract Objective Cervical cancer is linked with the constitutive activation of growth factors and gene mutations-induced pro-survival signaling pathways. Herein, we purposed to explore the possible molecular mechanism of Foxo3a-mediated DNMT3B in the proliferation and migration of cervical cancer cells via mediating the PTEN promoter methylation. Methods Foxo3a expression in cervical cancer was tested
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Curcumin Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Neutrophil Extracellular Traps Formation J. Invest. Surg. (IF 1.9) Pub Date : 2023-01-05 Cunle Zhu, Shangheng Shi, Peng Jiang, Xijian Huang, Jinxin Zhao, Yan Jin, Yuntai Shen, Xin Zhou, Huan Liu, Jinzhen Cai
Abstract Background Hepatic ischemia-reperfusion injury (IRI) is a common innate immune-mediated sterile inflammatory response in liver transplantation and liver tumor resection. Neutrophil extracellular traps (NETs) can aggravate liver injury and activates innate immune response in the process of liver IRI. However, Curcumin (Cur) can reverse this damage and reduce NETs formation. Nevertheless, the
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Development of a New Model of Humeral Hemiarthroplasty in Rats J. Invest. Surg. (IF 1.9) Pub Date : 2023-01-02 Efi Kazum, Eran Maman, Zachary T. Sharfman, Reut Wengier, Osnat Sher, Amal Khoury, Ofir Chechik, Oleg Dolkart
Abstract Purpose In vivo models are anatomically comparable to humans allowing to reproduce the patterns and progression of the disease and giving the opportunity to study the symptoms and responses to new treatments and materials. This study aimed to establish a valid and cost-effective in vivo rat model to assess the effects of implanted shoulder hemiarthroplasty materials on glenoid articular cartilage
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Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1/Nrf2 Pathway J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-28 Youcheng Zeng, Guodong Cao, Liang Lin, Yixin Zhang, Xiqing Luo, Xiaoyu Ma, Akelibieke Aiyisake, Qinghong Cheng
Abstract Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction secondary to septicemia. It is a major concern owing to the high mortality and morbidity, which are greatly influenced by ferroptosis. Resveratrol (RSV) is a naturally existing agonist of the silent information regulator 1 (Sirt1). It has cardioprotective effects against sepsis-induced myocardial injury, However
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Authors’ Reply to the Letter to the Editor: “Comprehensive Assessment of Inflammatory Indices to Predict Outcomes in Acute Pancreatitis” J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-28 Murat Biyik, Zeynep Biyik, Mehmet Asil, Muharrem Keskin
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Comprehensive Assessment of ERα, PR, Ki67, P53 to Predict the Risk of Lymph Node Metastasis in Low-Risk Endometrial Cancer J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-15 Yuzhen Huang, Peng Jiang, Wei Kong, Yuan Tu, Ning Li, Jinyu Wang, Qian Zhou, Rui Yuan
Abstract Purpose According to international guidelines, selective lymph node dissection can be performed on patients with early-stage endometrial cancer. However, some patients at early stage have already occurred lymph node metastasis at the time of diagnosis. This study was aimed to find a method to predict the risk of lymph node metastasis in this part of patient. Methods We collected data from
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Clinical Efficacy of Intraoperative Ultrasound for Prophylactic Lymphadenectomy of the Lateral Cervical Neck in Stage CN0 Papillary Thyroid Cancer: A Prospective Study J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-15 Yi Shen, Xiaoen Li, Lingling Tao, Yupan Chen, Rongli Xie
Abstract Background: To evaluate the clinical effectiveness of lateral cervical region (LCR) lymphadenectomy as a preventative procedure for stage CN0 papillary thyroid cancer (PTC).Methods: From December 2019 to October 2021, 108 patients with CN0 stage PTC hospitalized to our general surgery department were recruited. After analysis, the clinical data of these patients were separated into two groups:
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Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-15 Shumei Li, Yajie Cui, Min Li, Wenting Zhang, Xiaoxue Sun, Zhaoxu Xin, Jing Li
Abstract Objective Glucocorticoids are widely used in clinical practice; however, they can cause side effects, such as osteoporosis. Acteoside (ACT) from Cistanche has been used to combat a variety of diseases. The study was conducted to evaluate the efficacy of ACT in glucocorticoid-induced osteoporosis (GIOP) and its potential mechanism. Methods Dexamethasone (Dex) was injected intramuscularly to
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Management of Patients with Chronic Liver Disease in the Perioperative Period J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-15 Joseph B. Oliver MD MPH, Aziz M. Merchant MD, Baburao Koneru MD MPH
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Comprehensive Assessment of Inflammatory Indices to Predict Outcomes in Acute Pancreatitis J. Invest. Surg. (IF 1.9) Pub Date : 2022-12-14 Bhavana Tiwari, Ankur Sharma, Vishesh Vashishtha
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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A Narrative Review of Nutritional Therapy for Gastrointestinal Cancer Patients Underwent Surgery J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-30 Yujie Zhang, Jinglin Zhang, Lili Zhu, Jiaqi Hao, Fengjun He, Tao Xu, Rui Wang, Wen Zhuang, Mojin Wang
Abstract Background: Patients with gastrointestinal cancer often suffer from malnutrition during tumor progression. Malnutrition is associated with postoperative complications and decreased quality of life. Supporting cancer patients with proper nutrition is vital for improving their prognoses. Method: Google scholar and PubMed database searches were performed. Selection criteria included gastrointestinal
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The Effects of Radioiodine Therapy on the Recovery of Parathyroid Function in Patients with Protracted Hypoparathyroidism after Total Thyroidectomy for Papillary Thyroid Carcinoma J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-21 Munire Abuduwaili, Wusiman Baidula, Baoying Xia, Zhujuan Wu, Ziwei Chen, Zhichao Xing, Anping Su
To determine the effect of 131I treatment on postoperative parathyroid function and the timing of recovery of parathyroid function (RPF) in patients with protracted hypoPT.260 patients with papilla...
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The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-16 Bohan Zhang, Peng Luo, Jiachen Sun, Dawei Li, Zhaoxing Liu, Xinzhu Liu, Hongqing Zhao, Zhisheng Li, Xiaoye Xie, Jianqiu Yang, Chuan’an Shen
Abstract Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split-thickness skin excision three times on the same healthy non-scalp donor sites, with an interval of 14 days. The donor skin thus harvested was
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Predictive Survival Power of Combined Tumor Regression Grade (TRG) and Lymph Node Status in Patients with Esophageal Cancer J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-09 Saad Shebrain
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Inhibition of Caspase-11-Mediated Pyroptosis Alleviates Acute Kidney Injury Associated with Severe Acute Pancreatitis in Rats J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-09 Yang Shao, Chang Li, Yingjian Jiang, Hongbo Li, Xuefei Tang, Zhaoyu Gao, Dianliang Zhang
Abstract Background: Acute kidney injury (AKI) is a common complication in patients with severe acute pancreatitis (SAP). Caspase-11-mediated pyroptosis is essential for the progression of multiple diseases, but its role in SAP-induced AKI remains unknown. Aims: This research investigated whether caspase-11-mediated pyroptosis is involved in SAP-induced AKI and whether inhibiting caspase-11-mediated
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Management of Patients with Chronic Liver Disease in the Perioperative Period J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-09 Jiali Xing, Xueshuai Wan, Huayu Yang, Shunda Du
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Supracondylar Humerus Fractures in Infants and Toddlers: An Unexplored Area J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-08 R. Y. Kow, C. L. Low, M. S. Awang
Published in Journal of Investigative Surgery (Vol. 36, No. 1, 2023)
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Open Radiofrequency Ablation Combined with Splenectomy and Pericardial Devascularization vs. Liver Transplantation for Hepatocellular Carcinoma Patients with Portal Hypertension and Hypersplenism: A Case-Matched Comparative Study J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-08 Xishu Wang, Ximin Sun, Yongrong Lei, Jun Pei, Kuansheng Ma, Kai Feng, Wan Yee Lau, Feng Xia
Abstract Aim To compare the short- and long-term treatment outcomes of open radiofrequency ablation combined with splenectomy and pericardial devascularization versus liver transplantation for hepatocellular carcinoma patients with portal hypertension and hypersplenism. Methods During the study period, the treatment outcomes of consecutive HCC patients with portal hypertension and hypersplenism who
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Suberosin Alleviates Sepsis-Induced Lung Injury in A Rat Model of Cecal Ligation and Puncture J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-08 Sevgi Karabulut Uzunçakmak, Zekai Halıcı, Songül Karakaya, Zerrin Kutlu, Yavuz Selim Sağlam, İsmail Bolat, Pelin Aydın, Ceyda Sibel Kılıç
Abstract Background/aims Sepsis is one of the major problems encountered in intensive care units, causing organ damage and increasing mortality. Suberosin (SBR) is a type of coumarin with antioxidant and anti-inflammatory activities. The goal of this study is to explore the protective effects of SBR on the lungs in a rat model of sepsis. Methods Male Wistar rats were utilized in this study. A cecal
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Recurrence and Survival Rates of Patients Who Undergo Minimally Invasive Surgery for Endometrial Carcinoma with Different Prognostic Risk Groups J. Invest. Surg. (IF 1.9) Pub Date : 2022-11-07 Bin Liu, Jie Lin, Wenju Liu, Weiting Chen, Wanzhen Lin, Wei Chen
Abstract Objective To compare the recurrence rate and prognosis between minimally invasive surgical (MIS) approach and open surgical approach of endometrial carcinoma (EC) patients with different prognostic risk groups. Methods A retrospective analysis of all cases undergoing EC surgery between January 2011 and March 2018 was performed. The patients were grouped according to the management guidelines
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Splenic Abscesses in Endocarditis: A Rare Disease with High Mortality. The Experience of a Heart Institute in Brazil J. Invest. Surg. (IF 1.9) Pub Date : 2022-10-06 Roberto Rasslan, Vinicios Alves, Sergio Henrique Bastos Damous, Antonio de Santis, Flavio Tarasoutchi, Calos Augusto Metidieri Menegozzo, Masahiko Akamine, Samir Rasslan, Edivaldo Massazo Utiyama
ABSTRACT Introduction Splenic abscess secondary to endocarditis is a rare complication with high mortality. The treatment modality, splenectomy versus percutaneous drainage, and the best time, before or after valve replacement, are controversial. In the literature, there are only a few small case series about the subject. The objective of this study is to analyze the experience of a referral center
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Pancreatic Cancer: A Review of Current Treatment and Novel Therapies J. Invest. Surg. (IF 1.9) Pub Date : 2022-10-03 Hordur Mar Kolbeinsson, Sreenivasa Chandana, G. Paul Wright, Mathew Chung
Abstract Pancreatic cancer is one of the leading causes for cancer-related deaths in the United States. Majority of patients present with unresectable or metastatic disease. For those that present with localized disease, a multidisciplinary approach is necessary to maximize survival and optimize outcomes. The quality and safety of surgery for pancreatic cancer have improved in recent years with increasing
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Targeting the PANoptosome with 3,4-Methylenedioxy-β-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal İschemia-Reperfusion Injury J. Invest. Surg. (IF 1.9) Pub Date : 2022-09-28 Erdal Uysal, Mehmet Dokur, Faruk Kucukdurmaz, Serdar Altınay, Sait Polat, Kadir Batcıoglu, Efe Sezgın, Tuğçe Sapmaz Erçakallı, Aslı Yaylalı, Yakup Yılmaztekin, Zafer Cetın, İlker Saygılı, Osman Barut, Hatem Kazımoglu, Gokturk Maralcan, Suna Koc, Turkan Guney, Nadire Eser, Mehmet Sökücü, Sema Nur Dokur
Abstract Objectıves The objectives of this study were a) to investigate the effect of targeting the PANoptosome with 3,4-methylenedioxy-β-nitrostyrene (MNS) on PANoptosis in the Renal ischemia-reperfussion (RIR) model b) to investigate the kidney protective effect of MNS toward RIR injury. Methods Thirty-two rats were divided into four groups randomly. The groups were assigned as Control, Sham, DMSO
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Is Tumor Regression Grade Sufficient to Predict Survival in Esophageal Cancer with Trimodal Therapy? J. Invest. Surg. (IF 1.9) Pub Date : 2022-09-27 Yi-Min Gu, Si-Mian Lyu, Qi-Xin Shang, Han-Lu Zhang, Yu-Shang Yang, Wen-Ping Wang, Yong Yuan, Long-Qi Chen
Abstract Background This study aimed to assess the predictive value of tumor regression grade (TRG) and nodal status on survival in esophageal carcinoma with neoadjuvant chemoradiotherapy (nCRT). Methods Tumor pathologic regression and nodal status were assessed. Differences in survival stratified by TRG or nodal status were analyzed using the Kaplan–Meier method and log–rank test. The prognostic value