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Metastasis of Clear Cell Renal Cell Carcinoma to Uterine Leiomyoma: First Case Report and Review of Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-27 Sarvenaz Karamooz, Paula D. Binsol, Jaya Ruth Asirvatham, Anjali Pargaonkar
Metastasis of clear cell renal cell carcinoma (clear cell RCC) to the gynecologic tract is infrequent, and involvement of the uterus is extremely rare. A review of the literature identified a total of 12 reported examples with metastasis to the uterine serosa (1), endometrium (5), cervix (5) and only one with metastasis to the myometrium. This report represents the first case of tumor-to-tumor metastasis
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Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-23 Salim Barquet-Muñoz, Antonio Bandala-Jaques, Ma Delia Perez-Montiel, Diddier Prada, Marithe Martínez-Flores, Rosa A. Salcedo-Hernández, Carlos Pérez-Plasencia, Aaron Gonzalez-Enciso, David Cantu-de Leon
IntroductionDescribe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy.MethodsObservational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial
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Retroperitoneal Sarcomatoid Yolk Sac Tumor in a Chemotherapy-Naive Patient With Testicular Postpubertal Type Teratoma: A Rare Case Report With Emphasis on Molecular Features Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-20 Bo Zhang, Payal Kapur, Prasad R. Koduru, Liwei Jia
Sarcomatoid yolk sac tumor is a very rare histologic type of testicular germ cell tumor and is mainly reported in testicular germ cell tumor patients who receive chemotherapy. Herein, we report an extremely rare concurrent retroperitoneal sarcomatoid yolk sac tumor in a man with a testicular postpuberal teratoma before he received chemotherapy. A 37-year-old man initially presented with a persistent
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Cribriform-morular Thyroid Carcinoma Arising in a Medulloblastoma Survivor: Two Metachronous Tumors Shared with the Activation of the Wnt Signaling Pathway Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-20 Minghua Luo, Yaoli Chen, Xiaomin Yin, Jian Li
Wnt signaling pathway activation is involved in the pathogenesis of a series of malignant tumors and is characterized by the nuclear accumulation of β-catenin protein. The occurrence of two or more Wnt pathway-associated tumors in a single individual is uncommon and generally attributed to inherited cancer syndrome, especially familial adenomatous polyposis (FAP). Herein, we presented a rare case of
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Canalicular-Like Pleomorphic Adenoma of the Parotid Gland: A Recently Classified Tumor Highlighting the Use of Frozen Section Analysis and Surrogate IHC for Gene Rearrangement Defined Subtypes Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-20 Adam E. Brown, Annica C. Eells, Michael L. Hinni, Alessandra C. Schmitt
Canalicular-like pleomorphic adenomas are a relatively recently described entity, that possess features of both canalicular adenomas and pleomorphic adenomas. The presence of unusual HMGA2-fusion partners (most commonly HMGA2::WIF1 gene fusions) has established canalicular-like pleomorphic adenoma as a distinct entity. The use of intraoperative frozen section analysis and surrogate HMGA2 IHC are 2
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Gynecologic Adnexal Tumors and Tumor-Like Lesions in Children and Adolescents: Experience at a Cancer Center Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-20 João Costa, Sara Alves, Fernanda Silva, Filipa Leite, Carla Bartosch
Introduction. Tumors and tumor-like lesions of the uterine adnexa in children and adolescents are uncommon but may carry devastating consequences. Methods. We conducted an observational retrospective cohort study, to describe patients aged 0 to 19 years diagnosed with tumors and tumor-like lesions of the uterine adnexa at our institution between 2000 and 2018. Results. Eighty-nine patients with 105
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Elusive and Aggressive: Unraveling SMARCB1/INI1-Deficient Undifferentiated Carcinoma With Rhabdoid Features Arising From the Colon: A Case Report and Comprehensive Literature Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-20 Xiaoqin (Lucy) Liu, Diana Agostini-Vulaj
Undifferentiated carcinomas are highly aggressive tumors with a dismal prognosis. A subset of these tumors has been associated with inactivation or mutations of the Switch/Sucrose Nonfermenting (SWI/SNF) remodeling complex. Our understanding of the relationship between the clinicopathological features and molecular profiling of SWI/SNF-deficient undifferentiated carcinoma is still evolving due to its
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Chondrolipoma of the Breast: A Myofibroblastoma Variant or a Distinct Lesion? Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-15 Adrienne A. Workman, Donald C. Green, Edward G. Hughes, Parth S. Shah, Jeffrey M. Cloutier, Jonathan D. Marotti
The entity commonly referred to as chondrolipoma is a rare and enigmatic breast lesion with unclear histogenesis and a complete lack of molecular characterization. It is uncertain whether it represents a hamartoma, choristoma, or a distinct neoplasm, including possibly a variant of mammary-type myofibroblastoma. We report two additional chondrolipomatous lesions of the breast. The lesions had varying
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A Case Report of Carcinoid With Teratoma Arising From the Renal Hilum Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-09 Sachiko Shokei, Mamiko Nagase, Asuka Araki, Hirochika Nakajima, Koichiro Wada, Daisuke Niino
Teratoma is a germ cell tumor composed of 2 or 3 germ cell layers, and it can occur in various parts of the human body. However, teratomas of the renal hilum are particularly rare, and those complicated by carcinoids are even more uncommon. Herein, we report the example of an asymptomatic 49-year-old woman in whom a tumor in the right renal hilum was unexpectedly discovered on imaging. Histological
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Microscopic Growth Pattern of Metastatic Colorectal Carcinomas, Morphological Findings of the Non-Neoplastic Liver, and Their Relationship With Prognosis and Survival Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-09 Mine Özşen, Nesrin Uğraş, Ömer Yerci, Adem Deligonul, Pınar Taşar, Özgen Işık, Tuncay Yılmazlar
Introduction. Various clinicopathological, radiological, and molecular parameters are predictive of prognosis in patients with colorectal carcinoma and distant organ metastases continue to have a significant place among them. Recent studies reveal that not only the presence of metastases but also the histopathological growth pattern of the metastatic tumor significantly affects prognosis. This study
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Lipoprotein Glomerulopathy With Complete Resolution With Fenofibrate: Report of First Case From Pakistan Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-08 Nada Shaker, Ruwaida Ben Musa, Nuha Shaker, Humaira Nasir, Tafiya Erum Kamran, FNU Poombal, Abdul Abid, Rafat Abu Shakra, Ibrahim Mansoor
Background: Lipoprotein glomerulopathy is an infrequent glomerular disorder that culminates in nephrotic syndrome and often progresses to kidney failure. Whereas most patients have been reported in Japan and China, limited reports have been documented outside these regions. This patient represents the first report of lipoprotein glomerulopathy in Pakistan. Case Presentation: A 25-year-old male patient
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Cat Scratch Disease of the Breast/Axilla: Recognition of a Rare Disease and Approaches for Differential Diagnosis Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-08 Jing Wang, Mingfei Yan, Philip Bomeisl, Sarah Sree Cherian, Hannah Gilmore, Ruba Khattab, Aparna Harbhajanka
Cat scratch disease rarely presents as a breast or axillary mass mimicking carcinoma both clinically and radiologically. Diagnosing breast/axillary cat scratch disease is challenging due to its rarity and nonspecific findings. Here, we reported 2 patients with breast cat scratch disease and reviewed 14 patients with cat scratch disease involving breast/axilla from the past 30 years. It mainly affects
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Metastatic Granular Cell Tumor: A Rare Entity Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Dimosthenis Zylis, Stefania Kokkali, Michail Sofopoulos, Eirini Zografaki, Christine Vourlakou, Evangelia Skafida
Granular cell tumor, which is thought to recapitulate a Schwann cell phenotype, is a very rare neoplasm that belongs to soft tissue tumors. It can be classified as benign, atypical or malignant, based on specific histological criteria, with the majority of cases exhibiting an indolent behavior. Its biology and clinical course are poorly understood and its optimal management is yet to be defined, given
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Clinicopathological Characteristics and Prognosis Analysis of Lung Carcinoma With p40/TTF1 Coexpression and Lung Adenosquamous Carcinoma: Lung Carcinoma With p40/TTF1 Coexpression Is a Rare Tumor With High Metastatic Potential Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Rui Gao, Xi Zhang, Xiaoyan Chen, Xin Chen, Long Jin, Huawei Zheng, Xunbin Yu
Background. Lung carcinoma with p40/TTF1 coexpression (LC-PTC) is a very rare tumor with poor prognosis, and few cases have been reported to date. Objectives. To better understand biological behavior and prognosis of LC-PTC. Methods. We collected 9 examples of LC-PTC and compared them with 36 lung adenosquamous carcinomas during the same period in clinicopathologic characteristics, biologic behaviour
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Medical Students’ Perception of Pathology in Saudi Arabia Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Mehenaz Hanbazazh, Raneem M. Khashab, Nada K. Ameen, Maysaa A. Alghamdi, Lama S. Aldawsari, Samar M. Altoukhi, Saad Samargandy, Abeer Zakariyah
Pathology is the bridge between basic science and clinical practice. An inadequate perception of pathology leads to an incomplete understanding of diseases, which consequently affects its management. This study aims to identify medical students’ perceptions of pathology in medical colleges around Saudi Arabia and use their feedback to improve teaching strategies. A validated online self-structured
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Ciliated Muconodular Papillary Tumors of the Lung Harboring STRN::ALK Fusion: Case Report and Review of the Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Xinyi Zhang, Wei Yuan, Rongkui Luo, Lijuan Luan, Jie Huang, Shaohua Lu, Akesu Sujie, Yingyong Hou
Ciliated muconodular papillary tumor (CMPT) is a rare pulmonary tumor, typically occurring in middle-aged and elderly individuals. The molecular mutation spectrum of CMPT remains insufficiently explored. Commonly known driver gene alterations include KRAS, BRAF, EGFR, and ALK rearrangement. This report details the clinicopathological features of 2 patients presenting with CMPT as pulmonary nodules
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Clinicopathological Features of Three Rare EWSR1::NFATC2 Sarcomas of Bone and Soft Tissues Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Kemal Kosemehmetoglu, Bharat Rekhi, Zeynep Betul Erdem, Adalet Elcin Yildiz, Nil Comunoglu
Certain undifferentiated round cell sarcomas displaying EWSR1::NFATC2 fusion have recently been reported, mostly in the bones. This report presents clinicopathological features of 3 additional EWSR1::NFATC2 fusion sarcomas of bone and soft tissues. We present 2 soft tissue and 1 bone tumors: A 62-year-old man with pain and a slowly growing, 8-cm-sized soft tissue mass in the anterolateral compartment
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Expression of PSMA in Tumor-Associated Vasculature Predicts Poorer Survival in Patients With Hepatocellular Carcinoma and Is Likely Associated With PD-L1 Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-07 Rena X. Li, Yansheng Hao, Mark Ettel
BackgroundPSMA (prostate-specific membrane antigen) is a type II transmembrane glycoprotein recently found to be expressed in hepatocellular carcinoma (HCC). We aimed to characterize the expression pattern of PSMA in HCC and its association with clinicopathologic parameters and other biomarkers.MethodsImmunohistochemical studies for PSMA were performed on a previously established tissue microarray
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Succinate Dehydrogenase Deficient Renal Cell Carcinoma With Sarcomatoid and Rhabdoid Features—A Diagnostic Dilemma Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-05 Namra Ajmal, Costas D. Lallas, Peter McCue, Li Li
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare epithelial tumor with a biallelic mutation involving any subunit of the SDH complex. Mostly, it has low-grade morphology and a favorable prognosis. We present a case of a 36-year-old woman with weight loss, night sweats, and symptomatic anemia. Her imaging showed a hypo-enhancing heterogeneous right renal mass with invasion
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A Case of Myxoid Pleomorphic Liposarcoma with Rhabdoid Cells: A Diagnostic Pitfall Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-05 Takuma Arai, Ikuma Kato, Yusuke Kawabata, Shinichi Tsujimoto, Yoshihiro Ishikawa, Shingo Kato, Masanobu Takeyama, Shoji Yamanaka, Kenichi Kohashi, Yoshinao Oda, Satoshi Fujii
Myxoid pleomorphic liposarcoma (MPLS) is an extremely rare tumor listed in the fifth edition of the WHO classification (2020). Histologically, it mainly comprises a mixture of myxoid and pleomorphic liposarcoma-like components. Genetically, it lacks FUS/EWSR1::DDIT3 fusion and MDM2 amplification. Herein, we describe an example of MPLS with rhabdoid cells in a 10-year-old girl who presented with a growing
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Gastric Perineurioma: A Rare Entity with Molecular Analysis and Literature Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-05 Alyssa M. Vitale, Fatima Alruwaii, Dhananjay A. Chitale, Beena Ahsan
BackgroundPerineuriomas of the gastrointestinal tract are benign neoplasms that commonly develop in the distal colon and are identified during screening colonoscopy; however, perineuriomas of the stomach are exceedingly rare and less frequently identified. Differentiating gastric perineuriomas from other more serious gastric neoplasms is critical to avoid unnecessarily aggressive treatments. Thus far
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Ever Expanding Morphologic Patterns of Mesonephric-like Adenocarcinomas of the Uterine Corpus: A Report of Two Tumors and a Brief Review of the Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-05 M. Ruhul Quddus, Cara A. Mathews, Kamaljeet Singh
Mesonephric-like adenocarcinoma (MLA) of the endometrium shows a variety of morphologic appearances, including small glands, tubules with eosinophilic materials in the lumen, prominent papillary patterns, spindled cells, solid formations, and corded and hyalinized patterns. Unique morphology, characteristic immunohistochemical staining patterns, molecular alterations, and awareness of the pathologists
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Recurrent MTOR Mutations in Renal Cell Carcinoma With Fibromyomatous Stroma: A Report of 2 Tumors Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-05 Ejas Palathingal Bava, Nilesh Gupta, Fatimah I. Alruwaii, Ryan Nelson, Khaleel I. Al-Obaidy
Renal cell carcinoma with fibromyomatous stroma, recognized as a provisional entity in the current 2022 World Health Organization classification of renal neoplasms, is rare. Recent evidence suggests recurrent alterations in the mTOR pathway, supporting its recognition as a distinct entity. Herein, we report 2 renal cell carcinomas with fibromyomatous stroma with MTOR mutations occurring in 62- and
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ALK-Rearranged Epithelioid and Spindle Cell Neoplasm of the Sinonasal Tract Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Peipei Zhu, Jian Wang
Anaplastic lymphoma kinase (ALK)-rearranged mesenchymal neoplasms (non-inflammatory myofibroblastic tumor and non-epithelioid fibrous histiocytoma) have been recently described which tend to occur in the superficial and deep soft tissues. Occurrence as a primary sinonasal neoplasm has not been reported thus far. Herein, we describe the first case of sinonasal ALK-rearranged mesenchymal tumor that harbored
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GRM1-Rearranged Chondromyxoid Fibroma With FGF23 Expression: A Potential Pitfall in Small Biopsies Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Isidro Machado, Yanming Zhang, Meera Hameed, Sinchun Hwang, Aarti E. Sharma, Mark H. Bilsky, Konstantinos Linos
The clinical, radiological, and histopathological features of chondromyxoid fibroma can sometimes resemble those of other benign or malignant tumors. Recently, recurrent GRM1 rearrangements have been identified in chondromyxoid fibroma, and GRM1 positivity by immunohistochemistry has emerged as a dependable surrogate marker for this molecular alteration. Phosphaturic mesenchymal tumor is a rare tumor
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Multiple Gastrointestinal Stromal Tumors, Malignant Peripheral Nerve Sheath Tumor and Atypical Neurofibromatous Neoplasm With Uncertain Biologic Potential Developing in A Single Patient With Neurofibromatosis Type 1 Syndrome Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Elif Cerrah, Cem Çomunoğlu
Neurofibromatosis type 1 (NF1) is the most common human genetic disease. In these patients, the incidence of malignant peripheral nerve sheath tumors (MPNST) and gastrointestinal stromal tumors (GIST) is increased. A male patient in his forties with neurofibromatosis 1, presented with the coexistence of multiple GISTs located at intestinal and colonic mesentery, MPNST located at his leg and atypical
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Ruptured Saccular Aneurysm Caused by Necrotizing Arteritis of the Polyarteritis Nodosa Type in Primary Angiitis of Central Nervous System Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Toshiharu Matsumoto, Kanako Ogura, Joji Tokugawa, Takashi Mitsuhashi, Makoto Hishii
Primary angiitis of central nervous system (PACNS) is a rare idiopathic vasculitis that typically involves small arteries. An 18-year-old woman was operated on for resection of a ruptured aneurysm in a cerebral artery. Multiple aneurysms of cerebral arteries had been detected by neuroimaging examinations since the age of 12, and she had been administered drugs following a diagnosis of PACNS since the
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Stepwise Analysis of Resection Margin Impact on Survival and Distant Metastasis in Pancreatic Head Ductal Adenocarcinoma Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Florian N. Loch, Carsten Kamphues, Freschta Rieger, Katharina Beyer, Wael Rayya, Christian Schineis, Frederick Klauschen, David Horst, Simon Schallenberg, Mihnea P. Dragomir
The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective study included specimens from 75 patients who underwent oncological resection of pancreatic head PDAC between February 2013 and July 2020. Two pathologists
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Primary Papillary Colonic Adenocarcinoma With PDGFRA Mutation. A New Morphological Subtype? A Case Report and Review of Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Judith González-López, Sarai Palanca, Jorge Sancho-Muriel, Cristina Martínez-Chicote, Francisco Giner
Classic colon carcinomas are defined as adenocarcinomas, characterized by groups of medium/large cells with basophilic and polymorphous nuclei and an eosinophilic elongated cytoplasm, that rearrange on glandular structures. Signs of poor prognosis include high tumor budding, lymphovascular and perineural invasion, poor differentiation, positive margins, and CDX2 loss. Less frequent colon carcinoma
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Primary Well-Differentiated Neuroendocrine Tumor/Carcinoid of the Prostate: Case Report and Review of Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Mohamed Alhamar, Shenon Sethi, Victor E. Reuter, Samson W. Fine
Primary well-differentiated neuroendocrine tumor (WDNT)/carcinoid of the genitourinary tract is rare. Many WDNT reported in the prostate gland have been seen in close association with conventional prostatic adenocarcinoma and/or label for prostate-specific immunohistochemical markers and are best considered prostatic adenocarcinomas with “carcinoid-like” features. We present a case of primary WDNT/carcinoid
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Rock on the Heart: A Case of Calcifying Fibrous Tumor Arising From the Pericardium and Literature Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Jiaqi Wang, Dong Chen, Jianfeng Shang, Fang Dong
Calcifying fibrous tumors are rare benign fibrous tumors that rarely occur in the heart. We report a 33-year-old woman who was found to have a benign pericardial tumor on health checkup, which was highly suspected to be a teratoma in clinical and imaging examination. After cardiac tumor resection, histopathological features showed scattered foci of psammoma bodies or calcification among collagenized
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Palmer Nodular Fasciitis Harboring a Novel SREBF1::USP6 Fusion Gene Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-02 Haider A. Mejbel, Gene P. Siegal, Shi Wei
The diagnosis of low-grade fibroblastic/myofibroblastic tumors of acral sites can be challenging. These tumors encompass a diverse group of neoplasms with a spectrum of biologic potential ranges from benign to overtly malignant. They often demonstrate significant clinical, radiologic, and immunophenotypic overlap, in which the molecular phenotype may play an important diagnostic role to arrive at the
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Upper Urothelial Tract Extraosseous Bone Formation: An Unexpected Finding and Differential Diagnostic Considerations Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-01 Susan K. Potterveld, Nancy Wang, Ankur R. Sangoi
Extraosseous bone formation of the upper urothelial tract is an unusual phenomenon with limited documentation in the uropathology literature, reported in only 2 clinical series of patients undergoing percutaneous nephrolithotomy for the management of renal stones. While speculations regarding the pathogenesis of this occurrence have been published, heterotopic ossification is still poorly understood
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Benign Adenomyoepithelioma: An Unrecognised Precursor of Ductal Carcinoma in Situ in Patient With Lynch Syndrome Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-02-01 Sean SW Park, Marcus Chan, Shanta Velaiutham, Ana Cristina Vargas
Currently, there is no robust evidence demonstrating a clear association between Lynch syndrome and non-malignant breast pathology such as adenomyoepithelioma. We report a case of benign breast adenomyoepithelioma, which after recurrence was associated with ductal carcinoma in-situ (DCIS) in a 41-year-old woman with Lynch syndrome, who lacked significant family history of breast or ovarian cancer.
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Uncovering the Unknown: Granulomatous Peritonitis After Right Ovarian Cystectomy at a Tertiary Care Center in South India—A Case Report Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-31 Shalini Radhakrishnan, Chaithra Gowthuvalli Venkataramana, Sharada Rai, Roshan Shetty
Background. Granulomatous peritonitis is a rare postoperative complication caused by a delayed hypersensitivity reaction to foreign substances. It can be challenging to diagnose owing to its vague presentations, and its possibility is often overlooked. Tubercular peritonitis and peritoneal carcinomatosis are the 2 crucial differential diagnoses that need to be taken into account. However, making a
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Extra-Ocular Sebaceous Carcinoma in Situ of the Arm of an Elder Male: An Unusual Presentation in an Atypical Location Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-31 Nada Shaker, Omar P. Sangueza, Nuha Shaker, Dinesh Pradhan
Background. Sebaceous carcinoma in situ outside the ocular region is an exceedingly uncommon. It is an intraepidermal neoplasm originating from sebaceous glands limited to the epidermis with no invasion into the underlying dermis or beyond. Although sebaceous carcinoma in situ is predominantly observed in ocular regions, particularly the eyelids, instances of its occurrence in extraocular locations
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A Single-Center Retrospective Analysis of Kaposi's Sarcoma: Is There a Relationship Between Emmprin/CD147 Expression and Biological Behavior? Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-31 Zarifa Yusifli, Rashad Ismayilov, Kemal Kosemehmetoglu, Gokhan Gedikoglu
Objectives. Emmprin (CD147/BSG) protein is estimated to play a key role in cell migration and chemoresistance in viral carcinogenesis. However, there are very limited studies investigating the CD147 in the oncogenesis of Kaposi's sarcoma-associated herpesvirus. This study aims to reveal the relationship between CD147 expression with histopathological parameters, disease pattern, and recurrence in Kaposi's
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Atrophic Kidney-Like Lesion—Case Report and Review of the Literature Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-31 Xin Wang, Elizabeth Lovelace, Richard R. Pacheco, Robert Pacheco, Michael E. Schuster, Adrien Bernstein, Mahmut Akgul, Andrea Lightle
Atrophic kidney-like lesion (AKLL) is a rare kidney lesion, which was recently suggested by the Genitourinary Pathology Society as a provisional entity. As of now, 16 examples of AKLL have been described in the literature. Here we report a new tumor which shows similar clinicopathologic characteristics with those previously reported in AKLL. Immunohistochemical (IHC) studies in the current lesion identified
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An Unusual Case of Clear Cell Chondrosarcoma With Early Metastatic Recurrence Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-31 Lucas Kasson, Gayathri Vijayakumar, Linus Lee, Charles Gusho, Ankica Braun, Ira Miller, Matthew W. Colman, Alan T. Blank
We present a case of a 58-year-old male who presented following 4 months of progressively worsening right upper extremity pain. Initial pathology demonstrated pleomorphic chondroblasts with increased mitotic activity indicating an intermediate grade (Grade 2) clear cell chondrosarcoma of the proximal humerus. Following surgical resection, the primary lesion demonstrated aggressive behavior and early
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Mechanistic Target of Rapamycin Kinase is a Common Convergent Pathway to Renal Neoplasia: A Contemporary Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-23 Zainab I. Alruwaii, Sean R. Williamson, Khaleel I. Al-Obaidy
Mechanistic target of rapamycin kinase (mTOR) is a member of the phosphatidylinositol-3-hydroxide kinase (PI3 K)-related protein kinase family that functions as a central regulator of cell growth, metabolism, proliferation, and survival. The role of the TSC-mTOR signaling pathway in kidney tumors has been implicated in some hamartoma syndromes; however, with the advent and wide utilization of molecular
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Non-IgG4-Related Fibrosing Mediastinitis Diagnosed on Core Needle Biopsy and Treated with Steroids: A Case Study and Review of the Differential Diagnoses Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-18 Kseniia Malkova, Alyeesha B. Wilhelm, Hamza Uddin, Ikenna Okereke, Vidarshi Muthukumarana
ObjectivesThis study aimed to investigate the histological characteristics and treatment efficacy of non-immunoglobulin G4-related fibrosing mediastinitis and discuss differential diagnoses for this rare entity.MethodsWe present a case study of non-immunoglobulin G4-related fibrosing mediastinitis diagnosed on core biopsy and treated with steroids. A total of four 18-gauge core needle biopsy specimens
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The Significance of Insulinoma-Associated Protein 1 in the Pathological Diagnosis of Small-Cell Lung Cancer in Biopsy Specimens Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-09 Limin Yan, Xueli Zhao, Liming Chang, Haixian Jiang, Zhiyong Zhang
Objective: Our purpose was to investigate the clinicopathological diagnostic value of immunohistochemical antibody for insulinoma-associated protein 1 (INSM1) in biopsy specimens of SCLC. Methods: Biopsy specimens of SCLC diagnosed at the pathology department of Tangshan Gongren Hospital from January 2022 to June 2023 were selected. INSM1 expression was detected and compared with conventional neuroendocrine
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Clinicopathological, Immunohistochemical, and Molecular Characteristics of Pigmented Microcystic Chromophobe Renal Cell Carcinoma with Favorable Prognosis Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-04 Xingmei Guo, Zhini Xiao, Haimin Xu, Kai Ren, Xiangyun Li, Yuan Kai Wu, Yang Liu, Luting Zhou, Lei Wang, Hengan Liu, Lei Dong, Hui Dong, Xiaoqun Yang
Background. Pigmented microcystic chromophobe renal cell carcinoma (RCC) is a subtype of chromophobe RCC. Its distinct histopathologic features are microcystic and microtubular pattern, pigmentation, and microcalcifications. Pigmented microcystic chromophobe RCC has ultrastructure, immunophenotypic structure, and molecular results similar to chromophobe RCC. Methods. We report five tumors of pigmented
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EBV-Associated Smooth Muscle Tumors With Autoimmune Hemolytic Anemia and Hepatitis B Infection: Report of a Previously Undescribed Neoplasm With Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-03 Qiaoli Zheng, Chaofu Wang, Yuxiu Zhang, Haimin Xu, Fei Yuan, Hongmei Yi
Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is rare in adults. The presence of intratumoral T lymphocytes and primitive rounded cells characterized this neoplasm. We report a 24-year-old Chinese man who developed EBV-SMT in the right adrenal gland with hepatitis B infection and autoimmune hemolytic anemia without a history of HIV infection, primary immune deficiency, organ transplantation
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Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-03 Nada Shaker, Heath Blankenship, Nuha Shaker, Ruwaida Ben Musa, Shuo Niu, Alaaeddin Alrohaibani, Ibrahim Mansoor, Rafat Abu Shakra, Omar P. Sangueza
Malignant mesothelioma of the tunica vaginalis is an extremely rare and aggressive tumor that is frequently encountered in elderly patients. The diagnosis of malignant mesothelioma of the tunica vaginalis poses a diagnostic challenge due to its infrequency and nonspecific clinical presentation. Histopathological examination and immunohistochemical staining are essential in differentiating this tumor
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GLI1-Altered Soft Tissue Tumor in the Tongue—A Case Report and Literature Review Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2024-01-03 Jenny Lik-Ka Tse, Joshua Hoi-Yan Ng
Background: Soft tissue tumors with fusions or amplifications of the GLI1 gene have distinctive molecular characteristics and have recently been considered a unique pathological entity, thus named “ GLI1-altered soft tissue tumors.” It is a rare mesenchymal neoplasm that involves soft tissues at any site. Case presentation: We report an example of this condition in a 13-year-old Chinese male patient
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Adipocytic Differentiation in a Sertoli Cell Tumor. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-28 Jordan Molina,Ali Dabaja,Nilesh Gupta,Fatimah I Alruwaii,Oudai Hassan,Khaleel I Al-Obaidy
Testicular sex cord-stromal tumors are clonal neoplasms, with the majority being of Leydig cell followed by Sertoli cell origins. In Leydig cell tumors, adipocytic differentiation has been previously reported as a possible distinguishing feature, which has not been reported in other sex cord-stromal tumors. Herein, we report a case of a 48-year-old man who presented with an incidentally discovered
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Loss of Histone H3K27 Trimethylation (H3K27me3) Expression as a Potential Diagnostic Pitfall in Sarcomatoid Carcinoma. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-23 Megan L Zilla,Ivy John,Rana Naous
Loss of histone H3K27 Trimethylation (H3K27me3) immunohistochemical expression is commonly used as an ancillary test and a surrogate marker for the diagnosis of malignant peripheral nerve sheath tumor (MPNST). A potential histological mimic of MPNST is sarcomatoid carcinoma. Prompted by an index specimen of sarcomatoid carcinoma with H3K27me3 loss and the lack of literature on such phenomenon, we sought
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Endometrial Polyp-Like Lesions Arising From Adenomyosis: Report of 5 Cases. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-23 Hailee St Louis,Idris L Renshaw,Oluwole Fadare
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Colonic de novo Clear Cell Adenocarcinoma of Intestinal-Type: A Case Report and Review of the Literature. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-23 Fuyu Li,Danni Chen,Jin Chen,Ling Nie
Colorectal clear cell adenocarcinomas are rare tumors. They can be divided into two types: intestinal- and Müllerian-type. Most intestinal-type clear cell adenocarcinomas show a composite morphology, and most early-stage (T1) intestinal-type clear cell adenocarcinomas have an adenoma component. We report an additional early-stage (T1) colonic clear cell adenocarcinoma that was a de novo adenocarcinoma
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Mixed Mesonephric-like Adenocarcinoma, Clear Cell Carcinoma, and Endometrioid Carcinoma Arising from an Endometriotic Cyst. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-22 Shunsuke Nagase,Harumi Saeki,Ayako Ura,Yasuhisa Terao,Toshiharu Matsumoto,Takashi Yao
Mesonephric-like adenocarcinoma is a rare neoplasm of the uterine corpus and ovary. Unlike prototypical mesonephric adenocarcinoma of the uterine cervix, which is considered of Wolffian origin, recent evidence suggests that mesonephric-like adenocarcinoma is a Mullerian tumor associated with endometriosis. We report here on a 48-year-old woman with a mixed carcinoma of the ovary that consisted of mesonephric-like
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Morphological Diversity of the Endometrium in Choriocarcinoma Specimens and its Role in Differential Diagnosis. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-22 Xiao Yaoxing,Zhong Fangfang,Li Wenzhi,Zhou Xianrong,Lu Xin,Tao Xiang
Introduction: The morphological characteristics of the endometrium in patients with choriocarcinoma have not been well described. We described the endometrial morphology patterns in 46 choriocarcinomas and analyzed their relationship with the clinicopathological characteristics of these patients. Methods: Forty-six patients diagnosed with choriocarcinoma that had sufficient endometrial tissues for
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Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-19 Yuichiro Hamamoto,Michihiro Kawamura,Hideo Mori,Hiroki Uchida,Kazuhiro Hiramatsu,Chiaki Katori,Hinako Asai,Hiroko Kawasaki,Taishi Minamino,Michiko Hashimoto,Shin-Ichi Nakatsuka,Kyotaro Yoshida
SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of SARS-CoV-2 vaccine. We report a rare example of Kikuchi disease in the cervical lymph nodes after SARS-CoV-2 vaccination. A 41-year-old man complained of a swollen neck and fever 9 days after the first dose of SARS-CoV-2 mRNA-1273 vaccine. Computed tomography revealed enlarged
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Blastic Plasmacytoid Dendritic Cell Neoplasm Presenting as a Mammary Gland Tumor in a Pediatric Patient: A Case Report. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-13 Baodan Yu,Chunping Liu,Pengfei Qin,Qingen Li,Xue Li
Emanating from a discrete category within the lympho-hematopoietic tumor system, as established by the World Health Organization in 2008, the blastic plasmacytoid dendritic cell neoplasm constitutes an uncommon malignant hematological disorder. It is routinely misidentified on account of its conspicuous dermatological manifestation, yet may insidiously permeate bone marrow and lymph nodes, involving
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Langerhans Cell Hyperplasia Mimicking Langerhans Cell Histiocytosis: A Rare Complication of COVID-19 Vaccination. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-09 Asim Qureshi,Murtadha Al Khabori,Ibrahim Hassan Al Haddabi,Hannia Qureshi,Zabah Jawa
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation of Langerhans cells, a type of immune cell that is normally present in the skin and various other tissues. LCH can affect people of any age but is most commonly diagnosed in children. We report a case of a patient with LCH who developed ipsilateral axillary lymphadenopathology post-COVID-19 vaccination
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Superior Vesical Fissure as an Incomplete Form of Bladder Exstrophy: A Case Report with Clinico-Pathological Correlation and a Comprehensive Literature Review. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-08 Javier Arredondo Montero,Mónica Bronte Anaut,Ada Yessenia Molina Caballero,Elena Carracedo Vega,Rosa Guarch Troyas,Alberto Pérez-Martínez
Multiple variants of classic bladder exstrophy have been described, all of them infrequent. Superior vesical fissure is a mild variant of this pathology in which genital involvement is scarce or absent. To date, there are only isolated reports of this entity. We report a full-term female patient of Arabian descent with a clinical and radiological diagnosis of superior vesical fissure that was surgically
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Soft Tissue Aneurysmal Bone Cyst in the Sartorius Muscle of a 13-Year-Old Boy Mimicking Myositis Ossificans: Case Report. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-06 Eva Manuela Pena-Burgos,Gabriela Serra Del Carpio,Daniel Bernabéu,Jose Manuel Cordero García,Eduardo Jose Ortiz-Cruz,Jose Juan Pozo-Kreilinger
INTRODUCTION A soft tissue aneurysmal bone cyst is an extremely rare tumor. The objective of the article is to present the clinical, radiological, and histopathological features of a very unusual neoplasm of soft tissues. CASE REPORT A 13-year-old male patient presented a painful, mobile, and rapidly growing mass on the posteromedial aspect of his left knee. Imaging studies revealed a mass that arose
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The Crucial Role of Clinicopathological Seminars in the Context of Modern Surgical and Pathology Practice. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-11-01 Suraj Ethiraj,Soumith Subhash
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Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-10-31 Felipe Carrasco-Tenezaca,Jennifer Moreira-Dinzey,Padmini A Manrai,Mayara Bearse,Sneha Burela,Peter Podany,Kamaljeet Singh,Fresia Pareja,Jennifer Zheng,Nicole E Muscato,Yuanxin Liang,Haiying Zhan,Uma Krishnamurti,Darin Dolezal,Jianhui Wang,Malini Harigopal
Breast carcinoma with tubulopapillary features is a newly described entity associated with poor prognosis with only 14 tumors reported in the literature. We report 2 additional tumors and identify novel immunohistochemical and molecular features of the tumor. The first tumor was from a 72-year-old woman with nonmetastatic breast carcinoma and the second was from a 32-year-old woman with metastatic
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Pseudoangiomatous Spindle Cell Lipoma: A Rare and Distinct Pattern of Lipomatous Tumors. Int. J. Surg. Pathol. (IF 1.2) Pub Date : 2023-10-31 Nada Shaker,Heath Blankenship,Nuha Shaker,Yazan Alhalaseh,Shuo Niu,Ibrahim Mansoor,Rafat Abu Shakra,Omar P Sangueza
Pseudoangiomatous spindle cell lipoma is a rare pattern within the spindle cell lipoma spectrum that exhibits a remarkable histological pattern characterized by its resemblance to vascular lesions, creating a pseudoangiomatous appearance. Approximately 20 to 30 reports have been described in the literature. In this context, we present an intriguing report of pseudoangiomatous spindle cell lipoma showcasing