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Clinical impact of the Kidney Failure Risk Equation for vascular access planning Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-13 Ulrika Hahn Lundström, Chava L Ramspek, Friedo W Dekker, Merel van Diepen, Juan Jesus Carrero, Ulf Hedin, Marie Evans
Background Risk-based thresholds for arteriovenous (AV) access creation has been proposed to aid vascular access planning. We aimed to assess the clinical impact of implementing the kidney failure risk equation (KFRE) for vascular access referral. Methods 16,102 nephrology-referred chronic kidney disease (CKD) patients from the Swedish Renal Registry 2008-2018 were included. The KFRE was calculated
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Klotho in pregnancy and intrauterine development – Potential clinical implications: a review from the European Renal Association CKD-MBD Working Group Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-13 Mehmet Kanbay, Ali Mutlu, Cicek N Bakir, Ibrahim B Peltek, Ata A Canbaz, Juan Miguel Díaz Tocados, Mathias Haarhaus
Intrauterine development is crucial for life-long health; therefore, elucidation of its key regulators is of interest for their potential prognostic and therapeutic implications. Originally described as a membrane-bound anti-aging protein, Klotho has evolved as a regulator of numerous functions in different organ systems. Circulating Klotho is generated by alternative splicing or active shedding from
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Pre-donation Assessment of Cystatin C to Improve Prediction of Pre- and Post-Donation GFR in Potential Living Kidney Donors Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-12 Jessica van der Weijden, Daan Kremer, Lisa B Westenberg, Jan-Stephan F Sanders, Robert A Pol, Ilja M Nolte, Martin H De Borst, Stefan P Berger, Stephan J L Bakker, Marco van Londen
Background and hypothesis Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most eGFR equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin C (CysC)-based estimates before donation may improve both estimation of current GFR and prediction of post-donation GFR. Methods We assessed the performance
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Sex differences in cancer outcomes across the range of eGFR Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-09 Richard Shemilt, Michael K Sullivan, Peter Hanlon, Bhautesh Jani, Nicole De La Mata, Brenda Rosales, Benjamin M P Elyan, James A Hedley, Rachel B Cutting, Melanie Wyld, David A McAllister, Angela C Webster, Patrick B Mark, Jennifer S Lees
Background and hypothesis People with chronic kidney disease (CKD) have increased incidence and mortality from most cancer types. We hypothesised that odds of presenting with advanced cancer may vary according to differences in eGFR, that this could contribute to increased all-cause mortality and that sex differences may exist. Methods Data were from Secure Anonymised Information Linkage Databank,
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Physical exercise: a polypill against chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-09 Pedro L Valenzuela, Adrián Castillo-García, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Alejandro Lucia
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development
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Efficacy, tolerability, and safety of the oral phosphate binder VS-505 (AP301) Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-06 Bing Zhuang, Liangying Gan, Bin Liu, Weijie Yuan, Ming Shi, Ai Peng, Lihua Wang, Xiaolan Chen, Tongqiang Liu, Shiying Zhang, Song Wang, Qing Gao, Baoxing Wang, Huixiao Zheng, Changhua Liu, Yuan Luo, Hong Ye, Hongli Lin, Yiwen Li, Qiang He, Feng Zheng, Ping Luo, Gang Long, Wei Lu, Kanghui Li, Junwei Yang, Yingxue Cathy Liu, Zhizheng Zhang, Xiaolin Li, Weifeng Zhang, Li Zuo
Background VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part phase 2 study evaluated the tolerability, safety, and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD). Methods In Part 1, patients received dose-escalated
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Cold atmospheric plasma for chronic kidney disease-related skin disorders Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-02 Siyue Zhai, Dingxin Liu, Hua Liu, Wanchun Li, Zifeng Wang, Meng Wang, Lei Chen, Hongli Jiang
Background and hypothesis An estimated 80% of individuals with chronic kidney disease (CKD) experience concomitant skin disorders, yet experimental research that elucidates the pathological changes in CKD-affected skin is limited. Cold atmospheric plasma (CAP) has shown promise in regulating keratinocyte proliferation, skin barrier function, and anti-inflammatory activity. We hypothesize that CAP emerges
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How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system? Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-01 Volker Vallon
What mechanisms can link the inhibition of SGLT2-mediated Na+-coupled glucose reabsorption in early proximal tubules to kidney and heart protection in patients with and without type 2 diabetes? Due to physical and functional coupling of SGLT2 to other sodium and metabolite transporters in the early proximal tubule (including NHE3, URAT1), inhibitors of SGLT2 (SGLT2i) reduce reabsorption not only of
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A comparison of the epidemiology of kidney replacement therapy between Europe and the United States: 2021 data of the ERA Registry and the USRDS Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-03-01 Vianda S Stel, Rianne Boenink, Megan E Astley, Brittany A Boerstra, Danilo Radunovic, Rannveig Skrunes, Juan C Ruiz San Millán, Maria F Slon Roblero, Samira Bell, Pablo Ucio Mingo, Marc A G J ten Dam, Patrice M Ambühl, Halima Resic, Olga Lucia Rodríguez Arévalo, Nuria Aresté-Fosalba, Jaume Tort i Bardolet, Mathilde Lassalle, Sara Trujillo-Alemán, Olafur S Indridason, Marta Artamendi, Patrik Finne,
Background and hypothesis This paper compares the most recent data on the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT from Europe to those from the United States (US), including comparisons of treatment modalities (haemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx)). Methods Data were derived from the annual
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Hyperkalemia treatment Standard Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-28 Biff F Palmer, Deborah J Clegg
Hyperkalemia is a common electrolyte disturbance in both inpatient and outpatient clinical practice. The severity and associated risk depends on the underlying cause and rate of K+ increase. Acute hyperkalemia requires immediate attention due to potentially life-threatening manifestations resulting from the rapid rise in plasma K+ concentration. Treatment is initially focused on stabilizing the cardiac
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Proximal versus distal diuretics in congestive heart failure Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-28 Massimo Nardone, Vikas S Sridhar, Kevin Yau, Ayodele Odutayo, David Z I Cherney
Volume overload represents a hallmark clinical feature linked to the development and progression of heart failure (HF). Alleviating signs and symptoms of volume overload represents a foundational HF treatment target that is achieved using loop diuretics in the acute and chronic setting. Recent work has provided evidence to support guideline-directed medical therapies, such as sodium glucose cotransporter
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A tool to predict the risk of lower extremity amputation in patients starting dialysis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-27 Bram Akerboom, Roemer J Janse, Aurora Caldinelli, Bengt Lindholm, Joris I Rotmans, Marie Evans, Merel van Diepen
Background and hypothesis Non-traumatic lower extremity amputation (LEA) is a severe complication during dialysis. To inform decision-making for physicians, we developed a multivariable prediction model for LEA after starting dialysis. Methods Data from the Swedish Renal Registry (SNR) between 2010 and 2020 were geographically split into a development and validation cohort. Data from NECOSAD between
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Alkaline phosphatase treatment of acute kidney injury - an update Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-24 Thei S Steenvoorden, Janneke A J Rood, Frederike J Bemelman, Roberto Armstrong-Jr, Henri G D Leuvenink, Joost W van der Heijden, Liffert Vogt
Through improved insight in the increasing incidence and detrimental effects of acute kidney injury (AKI), its clinical relevance has become more and more apparent. Although treatment strategies for AKI have also somewhat improved, an adequate remedy still does not exist. Finding one is complicated by a multifactorial pathophysiology and by heterogeneity in the patient population. Alkaline phosphatase
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Urine cotinine versus self-reported smoking and the risk of chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-23 Setor K Kunutsor, Richard S Dey, Daan J Touw, Stephan J L Bakker, Robin P F Dullaart
Background and hypothesis Evidence on the role of smoking in the development of chronic kidney disease (CKD) has mostly relied on self-reported smoking status. We aimed to compare the associations of smoking status as assessed by self-reports and urine cotinine with CKD risk. Methods Using the PREVEND prospective study, smoking status was assessed at baseline using self-reports and urine cotinine in
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IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1via the TLR4 signaling pathway Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-23 Yifan Zhu, Haidong He, Weiqian Sun, Jiajun Wu, Yong Xiao, Yinshun Peng, Ping Hu, Meiping Jin, Ping Liu, DongLiang Zhang, Jiajun Wu, Ting Xie, Lusheng Huang, Weiming He, Minggang Wei, Lishun Wang, Xudong Xu, Yuyan Tang
Background IgA nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits of galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4 are involved in the pathogenesis of IgAN. The role of gut microbiota on IgAN patients was recently investigated. However, whether gut microbial modifications of Gd-IgA1 through TLR4 play a role in IgAN
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Global health inequalities of chronic kidney disease: a meta-analysis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-20 Rachael Duff, Omodolapo Awofala, Muhammad Tahir Arshad, Emilie Lambourg, Peter Gallacher, Neeraj Dhaun, Samira Bell
Background and hypothesis Chronic kidney disease (CKD) is a significant contributor to global morbidity and mortality. This study investigated disparities in age, sex and socio-economic status in CKD and updated global prevalence estimates through systematic review and meta-analysis. Methods Five databases were searched from 2014 to 2022, with 14 871 articles screened, 119 papers included and data
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Relative survival in patients with cancer and kidney failure Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-20 Laia Oliveras, Brenda Maria Rosales, Nicole De La Mata, Claire M Vajdic, Nuria Montero, Josep M Cruzado, Angela C Webster
Background and hypothesis The population with kidney failure is at increased risk of cancer and associated mortality. Relative survival can provide insight into the excess mortality, directly or indirectly, attributed to cancer in the population with kidney failure. Methods We estimated relative survival for people all ages receiving dialysis (n = 4089) and kidney transplant recipients (n = 3253) with
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A European Renal Association (ERA) synopsis for nephrology practice of the 2023 European Society of Hypertension (ESH) Guidelines for the Management of Arterial Hypertension Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-16 Pantelis Sarafidis, Roland Schmieder, Michel Burnier, Alexandre Persu, Andrzej Januszewicz, Jean-Michel Halimi, Mustafa Arici, Alberto Ortiz, Christoph Wanner, Giuseppe Mancia, Reinhold Kreutz
In June 2023, the European Society of Hypertension (ESH) presented and published the new 2023 ESH Guidelines for the Management of Arterial Hypertension, a document that was endorsed by the European Renal Association (ERA). Following the evolution of evidence in recent years, several novel recommendations relevant to the management of hypertension in patients with chronic kidney disease (CKD) appeared
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Global epidemiology of kidney cancer Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-10 Luigi Cirillo, Samantha Innocenti, Francesca Becherucci
Kidney cancer (KC) is a disease with a rising worldwide incidence estimated at 400 000 new cases annually, and a worldwide mortality rate approaching 175 000 deaths per year. Current projections suggest incidence continuing to increase over the next decade, thus emphasizing the urgency of addressing this significant global health trend. Despite the overall increases in incidence and mortality, striking
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Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-08 Samar Abd ElHafeez, Anneke Kramer, Mustafa Arici, Miha Arnol, Anders Åsberg, Samira Bell, Julie Belliere, Carmen Díaz Corte, Gema Fernández Fresnedo, Marc Hemmelder, Line Heylen, Kristine Hommel, Julia Kerschbaum, Radomir Naumović, Dorothea Nitsch, Rafael Santamaria, Patrik Finne, Runolfur Palsson, Maria Pippias, Halima Resic, Mai Rosenberg, Carmen Santiuste de Pablos, Mårten Segelmark, Søren Schwartz
Background and hypothesis Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT
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How do SGLT2 inhibitors protect the kidney? A mediation analysis of the EMPA-REG OUTCOME trial Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-07 Christoph Wanner, Masaomi Nangaku, Bettina J Kraus, Bernard Zinman, Michaela Mattheus, Stefan Hantel, Martin Schumacher, Kristin Ohneberg, Claudia Schmoor, Silvio E Inzucchi
Introduction Mechanisms underlying kidney benefits with sodium-glucose cotransporter-2 (SGLT2) inhibition in heart failure and/or type 2 diabetes (T2D) with established cardiovascular disease are currently unclear. Methods We evaluated post hoc the factors mediating the effect of empagliflozin on a composite kidney outcome (first sustained estimate glomerular filtration rate ≥40% reduction from baseline
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Increased prevalence of kidney cysts in individuals carrying heterozygous COL4A3 or COL4A4 pathogenic variants Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-06 Mónica Furlano, Melissa Pilco-Teran, Marc Pybus, Víctor Martínez, Miriam Aza-Carmona, Asunción Rius, Vanessa Pérez-Gomez, Gerson Berná, Jaime Mazo, Jonathan Hernández, Leonor Fayos, Elizabet Viera, Ignasi Gich, Hugo Vergara Pérez, Elena Gomá Garcés, José Luis Albero Dolon, Elisabet Ars, Roser Torra
Background Clinical variability among individuals with heterozygous pathogenic/likely pathogenic (P/LP) variants in the COL4A3/COL4A4 genes (also called autosomal dominant Alport syndrome or COL4A3/COL4A4 related disorder) is huge; many individuals are asymptomatic or show microhematuria, while others may develop proteinuria and chronic kidney disease (CKD). The prevalence of simple kidney cysts (KC)
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Differences Between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate and Association with Mortality and Cardiovascular Events: Results from Three Cohorts of Adults with Diabetes Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-06 Daijun He, Bixia Gao, Jinwei Wang, Chao Yang, Shouling Wu, Shuohua Chen, Junjuan Li, Min Chen, Ming-Hui Zhao, Luxia Zhang
Background and hypothesis To explore the association between the differences between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFRdiff) with the risk of mortality and cardiovascular (CV) events in individuals with diabetes. Methods Three prospective cohorts analyzed data of adults with diabetes from the Incident, Development, and Prognosis of Diabetic Kidney Disease (INDEED)
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Glomerular hyperfiltration as a therapeutic target for CKD Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-02-01 Mehmet Kanbay, Sidar Copur, Cicek N Bakir, Adrian Covic, Alberto Ortiz, Katherine R Tuttle
The global burden of chronic kidney disease (CKD) is high and increasing. Early diagnosis and intervention are key to improve outcomes. Single nephron glomerular hyperfiltration is an early pathophysiologic manifestation of CKD that may result in absolute glomerular hyperfiltration, i.e. a high glomerular filtration rate (GFR) or be associated with normal or low GFR because of nephron loss (relative
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Avacopan for ANCA-associated vasculitis with hypoxic pulmonary haemorrhage Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-25 Aglaia Chalkia, Oliver Flossmann, Rachel Jones, Jagdish Ramachandran Nair, Thomas Simpson, Rona Smith, Lisa Willcocks, David Jayne
Background and hypothesis Pulmonary haemorrhage with hypoxia caused by ANCA-associated vasculitis (AAV) has a high early mortality. Avacopan, an oral C5a receptor antagonist, is an approved treatment for AAV, but patients with pulmonary haemorrhage requiring invasive pulmonary ventilation support were excluded from the ADVOCATE trial. Methods A retrospective, observational, multicentre case series
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Sparsentan is superior to losartan in the gddY mouse model of IgA nephropathy Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-25 Hajime Nagasawa, Seiji Ueda, Hitoshi Suzuki, Celia Jenkinson, Yusuke Fukao, Maiko Nakayama, Tomoyuki Otsuka, Teruyuki Okuma, Wilmelenne Clapper, Kai Liu, Mai Nguyen, Radko Komers, Yusuke Suzuki
Background The mechanism leading to the development of IgA nephropathy (IgAN) remains to be completely understood. Endothelin-1 (ET-1) as well as angiotensin II (AngII) promote glomerular injury, tubulointerstitial inflammation, and fibrosis leading to chronic kidney disease. Sparsentan, a dual endothelin angiotensin receptor antagonist (DEARA), recently received accelerated approval in United States
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Porcine endogenous retroviruses in xenotransplantation Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-25 Joachim Denner
Xenotransplantation using pig cells, tissues or organs is under development to alleviate the shortage of human donor organs. Meanwhile remarkably long survival times of pig organs in non-human primates were reported as well as the functionality of pig kidneys and hearts in brain-dead humans. Most importantly, two transplantations of pig hearts in patients were performed with survival times of the patients
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Long-term outcome of kidney function in patients with ANCA-associated vasculitis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-25 Beatriz Sanchez Alamo, Laura Moi, Ingeborg Bajema, Annelies Berden, Oliver Flossmann, Zdenka Hruskova, David Jayne, Maria Wester Trejo, Carin Wallquist, Kerstin Westman
Background Kidney involvement is common in ANCA associated vasculitis (AAV) and prognosis determined by the severity of kidney damage. This study focused on long-term kidney outcomes, defining possible risk factors and comparing the performance of three different histological classifications to predict outcomes for patients with AAV. Methods The dataset included 848 patients with newly diagnosed AAV
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Incidence, Risk Factors and Outcome of Postoperative Acute Kidney Injury in China Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-24 Yichun Cheng, Sheng Nie, Xingyang Zhao, Xin Xu, Hong Xu, Bicheng Liu, Jianping Weng, Chunbo Chen, Huafeng Liu, Qiongqiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Qijun Wan, Yan Zha, Ying Hu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Fan Fan Hou, Shuwang Ge, Gang Xu
Background and hypothesis Postoperative acute kidney injury (AKI) is a common condition after surgery, however, the available data about nationwide epidemiology of postoperative AKI in China from the large and high-quality studies is limited. This study was aimed to determine the incidence, risk factors, and outcomes of postoperative AKI among patients undergoing surgery in China. Methods This was
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Hyperkalaemia-related reduction of RAASi treatment associates with more subsequent inpatient care Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-20 Maria K Svensson, Toyoaki Murohara, Eva Lesén, Matthew Arnold, Thomas Cars, Krister Järbrink, Gengshi Chen, Naru Morita, Sudhir Venkatesan, Eiichiro Kanda
Background Hyperkalaemia is a barrier to achieving optimal, guideline-directed treatment with renin-angiotensin-aldosterone system inhibitors (RAASi) in patients with chronic kidney disease (CKD) and/or heart failure (HF). This study describes the association between hyperkalaemia-related RAASi treatment reduction and number of hospitalized days in patients with CKD and/or HF in Sweden and Japan. Methods
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Gut flora metagenomic analysis coupled with metabolic and deep immune profiling in chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-20 I-Wen Wu, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus, Rhian Resnick, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
Background and hypothesis Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. Methods To clarify the underlying host-microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome, and deep immunotyping, in a cohort
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GSDMD and GSDME synergy in the transition of acute kidney injury to chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-20 Zhengyue Chen, Caiming Chen, Kunmei Lai, Chengkun Wu, Fan Wu, Zhimin Chen, Keng Ye, Jingzhi Xie, Huabin Ma, Hong Chen, Yujia Wang, Yanfang Xu
Background and hypothesis Acute kidney injury (AKI) could progress to chronic kidney disease (CKD) and the AKI-CKD transition has major clinical significance. A growing body of evidence has unveiled the role of pyroptosis in kidney injury. We postulate that GSDMD and GSDME exert cumulative effects on the AKI-CKD transition by modulating different cellular responses. Methods We established an AKI-CKD
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Combining genotype with height-adjusted kidney length predicts rapid progression of ADPKD Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-16 Eugene W C Chen, Jiehan Chong, Manoj K Valluru, Miranda Durkie, Roslyn J Simms, Peter C Harris, Albert C M Ong
Introduction Our main objective was to identify baseline prognostic factors predictive of rapid disease progression in a large unselected clinical autosomal dominant polycystic kidney disease (ADPKD) cohort. Methods A cross-sectional analysis was performed in 618 consecutive ADPKD patients assessed and followed-up for over a decade. A total of 123 patients (19.9%) had reached kidney failure by the
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Outcome of immunosuppression in children with IgA vasculitis-related nephritis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-12 Katharina Rohner, Matko Marlais, Yo Han Ahn, Alaa Ali, Abrar Alsharief, Anja Blejc Novak, Marta Brambilla, Evrim Kargin Cakici, Cengiz Candan, Nur Canpolat, Eugene Yu-hin Chan, Stéphane Decramer, Madeleine Didsbury, Filipa Durao, Anne M Durkan, Ali Düzova, Thomas Forbes, Valentina Gracchi, Tulin Güngör, Tomoko Horinouchi, Belde Kasap Demir, Yasuko Kobayashi, Mikael Koskela, Eda Didem Kurt-Sukur, Claudio
Background and hypothesis IgA vasculitis with nephritis (IgAVN) is the most common vasculitis in children. Treatment recommendations are, due to a lack of evidence, based on expert opinion resulting in variation. The aim of this study was to describe clinical presentation, treatment and outcome of an extremely large cohort of children with biopsy proven IgAVN to identify prognostic risk factors and
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Uromodulin biology Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-10 Artemios G Karagiannidis, Marieta P Theodorakopoulou, Eva Pella, Pantelis A Sarafidis, Alberto Ortiz
Uromodulin is a kidney-specific glycoprotein which is exclusively produced by the epithelial cells lining the thick ascending limb and early distal convoluted tubule. It is currently recognized as a multifaceted player in kidney physiology and disease, with discrete roles for intracellular, urinary, interstitial, and serum uromodulin. Among them, uromodulin modulates renal sodium handling through the
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When to use either spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-09 Masatake Kobayashi, Nicolas Girerd, Faiez Zannad
Kidney disease frequently coexists with cardiovascular diseases, and this dual presence significantly amplifies the risk of adverse clinical outcomes. Shared pathophysiological mechanisms and common cardiovascular risk factors contribute to the increased expression of mineralocorticoid receptors, which in turn can drive the progression of chronic cardiovascular-kidney disorder. The steroidal mineralocorticoid
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International Consensus on post-transplantation diabetes mellitus Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-04 Adnan Sharif, Harini Chakkera, Aiko P J de Vries, Kathrin Eller, Martina Guthoff, Maria C Haller, Mads Hornum, Espen Nordheim, Alexandra Kautzky-Willer, Michael Krebs, Aleksandra Kukla, Amelie Kurnikowski, Elisabeth Schwaiger, Nuria Montero, Julio Pascual, Trond G Jenssen, Esteban Porrini, Manfred Hecking
Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment
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Cystic phenotype and chronic kidney disease in autosomal dominant Alport syndrome Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-04 Teresa Bada-Bosch, Angel M Sevillano, María Teresa Sánchez-Calvin, Carmen Palma-Milla, Ignacio Alba de Cáceres, Francisco Díaz-Crespo, Hernando Trujillo, Marina Alonso, Clara Cases-Corona, Amir Shabaka, Juan Francisco Quesada-Espinosa, José Miguel Lezana Rosales, Eduardo Gutiérrez, Gema Fernández-Juárez, Fernando Caravaca-Fontán, Manuel Praga
Background and hypothesis Autosomal Dominant Alport Syndrome (ADAS), also known as Thin Basement Membrane Disease (TBMD), is caused by pathogenic variants in COL4A3 and COL4A4 genes. A cystic phenotype has been described in some patients with TBMD, but no genetic studies were performed. We conducted a genetic and radiologic investigation in a cohort of ADAS patients to analyze the prevalence of multicystic
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Association between urinary C4d levels and disease progression in IgA nephropathy Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-03 Yaping Dong, Zi Wang, Weiyi Guo, Li Zhu, Xujie Zhou, Sufang Shi, Lijun Liu, Jicheng Lv, Hong Zhang
Background C4d mesangial deposition, a hallmark of lectin pathway activation in IgA nephropathy (IgAN), has been shown to be associated with risk of kidney failure. To date, the relationship between urinary C4d and renal outcome remain unelucidated. Methods A total of 508 patients with biopsy-proven IgAN were enrolled in this study, whose baseline urine samples at the time of biopsy were collected
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Risk factor analysis for a rapid progression of chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2024-01-02 Anne H S Vestergaard, Simon K Jensen, Uffe Heide-Jørgensen, Line E Frederiksen, Henrik Birn, Dorte E Jarbøl, Jens Søndergaard, Frederik Persson, Reimar W Thomsen, Christian F Christiansen
Background Chronic kidney disease (CKD) is a growing global health concern. Identifying individuals in routine clinical care with new onset CKD at high risk of rapid progression of the disease is imperative to guide allocation of prophylactic interventions, but community-based data are limited. We aimed to examine the risk of rapid progression, kidney failure, hospitalisation and death among adults
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Regional variation in incidence and prognosis of acute kidney injury Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-23 Simon Kok Jensen, Thomas Bøjer Rasmussen, Bjarke Hejlskov Jacobsen, Uffe Heide-Jørgensen, Simon Sawhney, Henrik Gammelager, Henrik Birn, Søren Paaske Johnsen, Christian Fynbo Christiansen
Background Examining regional variation in acute kidney injury (AKI) and associated outcomes may reveal inequalities and possibilities for optimization of the quality of care. Using the Danish medical databases, we examined regional variation in the incidence, follow-up, and prognosis of AKI in Denmark. Methods Patients with one or more AKI episodes in 2017 were identified using population-based creatinine
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Global, Regional, and National Burden of CKD in Children and Adolescents from 1990 to 2019 Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-22 Wen-Man Zhao, Xun-Liang Li, Rui Shi, Yuyu Zhu, Zhi-Juan Wang, Xue-Rong Wang, Hai-Feng Pan, De-Guang Wang
Background and Aims CKD is one of the most prevalent non-communicable health concerns in children and adolescents worldwide; however, data on its incidence, prevalence, disability-adjusted life years (DALYs), and trends in the population are limited. We aimed to assess the global, regional, and national trends in CKD burden in children and adolescents. Methods In this trend analysis based on the 2019
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Genome-wide association studies reconstructing chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-21 Anastasios Fountoglou, Constantinos Deltas, Ekaterini Siomou, Evangelia Dounousi
Chronic Kidney Disease (CKD) is a major health problem with increasing epidemiological burden, being the 16th leading cause of years life lost worldwide. It is estimated that more than 10% of the population have a variable stage of CKD, while about 850 million people worldwide are affected. Nevertheless, public awareness remains low, clinical access is inappropriate in many circumstances and medication
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Are patients with primary glomerular disease at increased risk of malignancy? Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-09 Jialin Han, Yinshan Zhao, Mark Canney, Mohammad Atiquzzaman, Paul Keown, Adeera Levin, Sean Barbour
Over the past decade, several observational studies and case series have provided evidence suggesting a connection between glomerular diseases (GN) and the development of malignancies, with an estimated risk ranging from 5%-11%. These malignancies include solid organ tumors as well as hematologic malignancies such as lymphoma and leukemia. However, these risk estimates are subject to several sources
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Heart Disease and Stroke Statistics 2023 Update from the American Heart Association - Implications for Nephrology Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-05 Nicola C Edwards, Charles J Ferro, John N Townend
The annual American Heart Association (AHA) and National Institutes of Health statistical report details the most up to date statistics related to heart disease, stroke, and cardiovascular risk factors, primarily within the USA. Although not a formal systematic review or meta-analysis, this 600 page report provides the most comprehensive and best summary of cardiovascular statistics for the year in
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Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-12-01 Eleni Stamellou, Shipra Agrawal, Florian Siegerist, Marc Buse, Christoph Kuppe, Tim Lange, Eva Miriam Buhl, Jessica Alam, Thiago Strieder, Peter Boor, Tammo Ostendorf, Hermann-Josef Gröne, Jürgen Floege, William E Smoyer, Nicole Endlich, Marcus J Moeller
Background and hypothesis Glucocorticoids are the treatment of choice for proteinuric patients with minimal-change disease (MCD) and primary focal and segmental glomerulosclerosis (FSGS). Immunosuppressive as well as direct effects on podocytes are believed to mediate their actions. In this study, we analyzed the anti-proteinuric effects of inhibition of the glucocorticoid receptor (GR) in glomerular
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Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease. Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-30 Zhenhong Guo,Feifei Zhong,Meng Hou,Jinlan Xie,A Zhong Zhang,Xinran Li,Yuan Li,Baocheng Chang,Juhong Yang
OBJECTIVE A ketogenic diet or mildly increased ketone body levels are beneficial for diabetic kidney disease (DKD) patients. Our previous study has found that sodium-coupled monocarboxylate transporter 1 (SMCT1), a key enzyme in charge of ketone reabsorption, possesses beneficial effects on the function of renal tubular epithelial cells (TECs) in energy crisis. Our present study is to investigate whether
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Reserved gait capacity and mortality among patients undergoing hemodialysis. Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-30 Shun Yoshikoshi,Shohei Yamamoto,Yuta Suzuki,Keigo Imamura,Manae Harada,Kentaro Kamiya,Atsuhiko Matsunaga
BACKGROUND Patients undergoing hemodialysis (HD) have difficulty increasing their gait speed in daily life. The extent of the increase from the usual gait speed (UGS) to the maximum gait speed (MGS) is considered the reserved gait capacity (RGC). Little is known regarding the implications of RGC. This study aimed to investigate the association between RGC and all-cause mortality in patients undergoing
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Cell-cell communication in kidney fibrosis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-30 Meizhi He, Zhao Liu, Li Li, Youhua Liu
Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which virtually all kinds of renal resident and infiltrating cells are involved. As such, well-orchestrated intercellular communication is of vital importance in coordinating complex actions during renal fibrogenesis. Cell-cell communication in multicellular organisms is traditionally assumed to be mediated by direct
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Chronic kidney disease and risk of kidney or urothelial malignancy: systematic review and meta-analysis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-29 Emily R Brooks, Mutita Siriruchatanon, Vinay Prabhu, David M Charytan, William C Huang, Yu Chen, Stella K Kang
Background Chronic kidney disease (CKD) is highly prevalent, affecting approximately 11% of U.S. adults. Multiple studies have evaluated a potential association between CKD and urinary tract malignancies. Summary estimates of urinary tract malignancy risk in CKD patients with and without common co-existing conditions may guide clinical practice recommendations. Methods Four electronic databases were
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Phosphorus balance calculator: an individualized tool for treatment of hyperphosphatemia in hemodialysis patients Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-29 Mengjing Wang, Jing Xiao, Qiuna Du, Weichen Zhang, Zhenwen Yan, Jianfeng Luo, Chen Yu, Zhibin Ye, Jing Chen
Background and hypothesis Lack of evaluations of the dietary phosphorus and dialysis phosphorus removal in daily clinical practice are the common obstacle to assess phosphorus balance and control phosphorus in hemodialysis patients. We aimed to investigate whether the individualized therapy using phosphorus balance calculator improves phosphorus control. Methods A randomized, open-label, multicenter
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Mental health and addiction service utilization among people living with chronic kidney disease Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-29 Arrti A Bhasin, Amber O Molnar, Eric McArthur, Danielle M Nash, Jason W Busse, Rebecca Cooper, Esti Heale, Jane Ip, Jocelyn Pang, Peter G Blake, Amit X Garg, Paul Kurdyak, S Joseph Kim, Heebah Sultan, Michael Walsh
Background Mental health problems, particularly anxiety and depression, are common in patients with chronic kidney disease (CKD), and negatively impact quality of life, treatment adherence, and mortality. However, the degree to which mental health and addictions services are utilized by those with CKD is unknown. We examined the history of mental health and addictions service use of individuals across
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Journey to kidney transplantation: patient dynamics, suspensions, transplantation and deaths in the Australian kidney transplant waitlist Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-29 Nicole L De La Mata, Victor Khou, James A Hedley, Patrick J Kelly, Rachael L Morton, Kate Wyburn, Angela C Webster
Background and hypothesis People on the kidney waitlist are less informed about potential suspensions. Disparities may exist among those who are suspended and who return to the waitlist. We evaluated the patient journey after entering the waitlist, including suspensions and outcomes, and factors associated with these transitions. Methods We included all incident patients waitlist for their first transplant
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Anaemia in CKD - treatment standard Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-28 Iain C Macdougall
Anaemia is one of the most common complications of chronic kidney disease (CKD), having a significant impact on quality-of-life, and is also associated with a number of adverse clinical outcomes. Its pathogenesis is multifactorial, caused largely by an inadequate production of erythropoietin from the diseased kidneys, with iron deficiency, inflammation, shortened red cell lifespan, and enhanced blood
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Arteriovenous access creation and hazards of hospitalization and death in patients starting hemodialysis. Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-27 Natalia Alencar de Pinho,Mathilde Prezelin-Reydit,Jerome Harambat,Cécile Couchoud,Florence Glaudet,Christian Combe,Virginie Rondeau,Karen Leffondré,
BACKGROUND Recent evidence suggests overestimation of benefits associated with arteriovenous (AV) fistula versus graft in certain populations. We assessed hazards of all-cause and cause-specific hospitalization and death associated with AV access type in patients who started hemodialysis with a catheter in France, overall and by subgroups of age, sex, and comorbidities. METHODS From the REIN Registry
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Fibrates and the risk of cardiovascular outcomes in chronic kidney disease patients Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-25 Hirohito Goto, Ken Iseri, Noriko Hida
Background and hypothesis The high risk of major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD) has been well described. However, the efficacy of fibrates on the risk of MACE in patients with CKD remains unclear. Methods We conducted a nested case-control study using data from a large administrative database that included more than 1.5 million Japanese patients.
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Kidney phosphate wasting predicts poor outcome in polycystic kidney disease. Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-20 Laixi Xue,Frank Geurts,Esther Meijer,Martin H de Borst,Ron T Gansevoort,Robert Zietse,Ewout J Hoorn,Mahdi Salih,
BACKGROUND AND HYPOTHESIS Patients with ADPKD have disproportionately high levels of fibroblast growth factor-23 (FGF-23) for their CKD-stage with only a subgroup that develops kidney phosphate wasting. We assessed factors associated with phosphate wasting and hypothesize that it identifies patients with more severe disease and predicts disease progression. METHODS We included 604 patients with ADPKD
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Higher beta-hydroxybutyrate ketone levels associated with a slower kidney function decline in ADPKD Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-17 Martine G E Knol, Thomas Bais, Paul Geertsema, Margery A Connelly, Stephan J L Bakker, Ron T Gansevoort, Maatje D A van Gastel, R T Gansevoort, J P H Drenth, D J M Peters, M Salih, J W de Fijter, T Nijenhuis, E J Hoorn, E Meijer
Background and hypothesis Dysregulated energy metabolism is a recently discovered key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Cystic cells depend on glucose and are poorly able to use other energy sources such as ketone bodies. Raising ketone body concentration reduced disease progression in animal models of polycystic kidney diseases. Therefore, we hypothesized that higher
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Difelikefalin improves itch-related sleep disruption in patients undergoing haemodialysis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-16 Daniel E Weiner, Thilo Schaufler, Kieran McCafferty, Kamyar Kalantar-Zadeh, Michael Germain, Despina Ruessmann, Isabelle Morin, Frédérique Menzaghi, Warren Wen, Sonja Ständer
Background Poor sleep quality is associated with increased mortality and lower quality of life in patients with chronic kidney disease-associated pruritus (CKD-aP). Difelikefalin reduces itch in patients with CKD-aP undergoing haemodialysis. This post hoc analysis of Phase 3 studies (3105 and the pooled dataset from KALM-1 and KALM-2) evaluated whether itch reduction in CKD-aP improved sleep quality
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Endothelial to mesenchymal transition in kidney fibrosis Nephrol. Dial. Transplant. (IF 6.1) Pub Date : 2023-11-14 Marleen E Jacobs, Dorottya K de Vries, Marten A Engelse, Sébastien J Dumas, Ton J Rabelink
Fibrotic disease are characterized by the uncontrolled accumulation of extracellular matrix (ECM) components leading to disruption of tissue homeostasis. Myofibroblasts as main ECM-producing cells can originate from various differentiated cell types after injury. Particularly, the process of endothelial-to-mesenchymal transition (endMT), describing phenotypic shifts of endothelial cells (ECs) to adopt