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Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis Immunol. Invest. (IF 2.8) Pub Date : 2024-03-13 Yan Meng, Xuan-lin Cai, Shan Cong, Jiao Sun, Yong-wei Hu, Yan-Qin Gu, Xiu-min Ma, Li Luo
This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rhe...
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Mogroside Ⅴ Inhibits M1 Polarization and Inflammation of Diabetic Mouse Macrophages via p38 MAPK/NF-Κb Signaling Pathway Immunol. Invest. (IF 2.8) Pub Date : 2024-02-28 Xiaoyi Dong, Zhimao Ye, Cuiping Li, Kongmei Li, Xiaoxia Zhong, Hao Li
Mogroside V (MV) has anti-inflammatory properties. However, its impact on macrophage polarization under diabetic condition is yet unclear. This study aimed to investigate effects and underlying mec...
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Extracellular Vesicles and the Immune System: From Immunological Function to Therapeutic Application Immunol. Invest. (IF 2.8) Pub Date : 2024-02-21 Aimin Jiang
Published in Immunological Investigations: A Journal of Molecular and Cellular Immunology (Ahead of Print, 2024)
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Letter from the Editor and Introduction to the 2023 Thematic Issue Immunol. Invest. (IF 2.8) Pub Date : 2024-02-21 Adam J. Adler
Published in Immunological Investigations: A Journal of Molecular and Cellular Immunology (Ahead of Print, 2024)
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Role of Extracellular Vesicles in Immunity and Host Defense Immunol. Invest. (IF 2.8) Pub Date : 2024-02-13 Puja Kumari, Skylar S. Wright, Vijay A. Rathinam
Extracellular vesicles (EVs) are membrane-bound structures released by cells and have become significant players in immune system functioning, primarily by facilitating cell-to-cell communication. ...
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Correlation Between B-Cell Activating Factor of the Tumor Necrosis Factor Family Level in Serum and Immune Inflammation in Patients with Neuropsychiatric Systemic Lupus Erythematosus and its Clinical Value Immunol. Invest. (IF 2.8) Pub Date : 2024-02-08 Jie Pang, Yanxia Li, Ran Tao, Jing Li, Feifei Wang, Huaheng Xu
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a form of SLE associated with severe NP syndromes causing mortality and morbidity. Respecting the fundamental of BAFF in NPSLE pathophysiolo...
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IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4+ T Lymphocyte Differentiation Immunol. Invest. (IF 2.8) Pub Date : 2024-02-08 Liou Huang, Chunrong Wu, Dan Xu, Yuhui Cui, Jianguo Tang
Complex pathophysiological the specific mechanism of sepsis on CD4+ T-cell responses is less well understood. IL1 receptor accessory protein (IL1RAP) was found to be involved in activating host imm...
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High Mobility Group Box 1 Gene Polymorphism and Serum High Mobility Group Box 1, Interleukin 1 Beta, and Alpha-Klotho Crosstalk in Severe COVID-19 Patients Immunol. Invest. (IF 2.8) Pub Date : 2024-02-06 Maha Houssen, Rasha El-Mahdy, Nouran E. Samra, Yousra Tera, Kamel Nayera Mostafa, Manal M. El-Desoky, Fatma Azzahraa Hisham, Asem A. Hewidy, Rehab A. Elmorsey, Hala Samaha, Rasha Mahmoud, Mona S. Abdelhafez
To evaluate the serum levels of HMGB1, IL1β, and α-klotho in COVID-19 patients with different disease severity, investigate their association with clinicopathological parameters, and to assess HMGB...
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Effect of CDK4/6 Inhibitors on Tumor Immune Microenvironment Immunol. Invest. (IF 2.8) Pub Date : 2024-02-05 Jie Liu, Min Cheng, Jiamei Xu, Yue Liang, Beibei Yin, Jing Liang
Cancer is an abnormal proliferation of cells that is stimulated by cyclin-dependent kinases (CDKs) and defective cell cycle regulation. The essential agent that drive the cell cycle, CDK4/6, would ...
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The Clinical Significance and the Potential Regulatory Mechanism of the LncRNA OIP5-AS1 in Paediatric Severe Community-Acquired Pneumonia Blood Through the MiR-150-5p/PDCD4 Axis Immunol. Invest. (IF 2.8) Pub Date : 2024-01-31 Juan Lu, Qingguo Ren, Weiwei Qi, Ning Yang, Yuanyuan He
This study aimed to elucidate the clinical significance and regulatory mechanism of the long non-coding RNA OIP5-AS1 in severe community-acquired pneumonia (SCAP) among paediatric patients.qRT-PCR ...
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Etiopathogenesis of Psoriasis: Integration of Proposed Theories Immunol. Invest. (IF 2.8) Pub Date : 2024-01-19 Brenda Fernanda Hernandez-Nicols, Juan José Robledo-Pulido, Anabell Alvarado-Navarro
Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin and the involvement of the immune system. Global prevalence for psoriasis has been reporte...
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Advances in Metabolic Regulation of Macrophage Polarization State Immunol. Invest. (IF 2.8) Pub Date : 2024-01-11 Xin Liu, Ruoxuan Xiang, Xue Fang, Guodong Wang, Yuyan Zhou
Macrophages are significant immune-related cells that are essential for tissue growth, homeostasis maintenance, pathogen resistance, and damage healing. The studies on the metabolic control of macr...
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Nanomedicine at the Pulmonary Frontier: Immune-Centric Approaches for Respiratory Disease Treatment Immunol. Invest. (IF 2.8) Pub Date : 2024-01-11 Jatinder Kaur, Akanksha Sharma, Gautam Passi, Piyush Dey, Akhil Khajuria, Hema Kumari Alajangi, Pradeep Kumar Jaiswal, Ravi Pratap Barnwal, Gurpal Singh
Respiratory diseases (RD) are a group of common ailments with a rapidly increasing global prevalence, posing a significant threat to humanity, especially the elderly population, and imposing a subs...
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In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis Immunol. Invest. (IF 2.8) Pub Date : 2024-01-10 Sankalp Gharat, Vivek Basudkar, Munira Momin
Topical nanogel-based formulations have shown potential in the management of rheumatoid arthritis (RA). The aim of this research work was to explore the synergistic effect of Curcumin (CUR) and Cyc...
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MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus Immunol. Invest. (IF 2.8) Pub Date : 2024-01-10 Xin Huang, Yixin Tan, Ruifang Wu, Qianwen Li, Shuaihantian Luo
MicroRNA-98-5p (miR-98-5p) plays a protective role in the pathogenesis of autoimmune diseases through anti-inflammatory effects, but little is known about its role in Systemic lupus erythematosus (...
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The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice? Immunol. Invest. (IF 2.8) Pub Date : 2024-01-03 Safoora Pordel, MohammadAli Rezaee, Malihe Moghadam, Mojtaba Sankian
The rapid uptake of antigens by antigen-presenting cells (APCs) and their migration to draining lymph nodes in the initial hours after antigen administration in epicutaneous allergen specific immun...
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Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children Immunol. Invest. (IF 2.8) Pub Date : 2023-12-20 Meng Yu, Yeyi Yang, Juan Zhang, Rui Liu, Lihua Huang, Jiping Wu, Zhijuan Kang, Jin Zhou, Zuocheng Yang
To investigate the association between loci rs3761847 and rs10818488 of tumor necrosis factor receptor-associated factor 1/complement C5 (TRAF1/C5) gene and the susceptibility to IgAV.100 blood sam...
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Role of MicroRNAs in Inflammatory Joint Diseases: A Review Immunol. Invest. (IF 2.8) Pub Date : 2023-12-14 Nazmul Huda Syed, Ali Mussa, Abdirahman Hussein Elmi, Mutaz Jamal Al-Khreisat, Muhammad Rajaei Ahmad Mohd Zain, Asma Abdullah Nurul
Inflammatory arthritis commonly initiates in the soft tissues lining the joint. This lining swells, as do the cells in it and inside the joint fluid, producing chemicals that induce inflammation si...
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Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of ‘A’ Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Line Immunol. Invest. (IF 2.8) Pub Date : 2023-12-14 Saniya Khan, Ayesha Anwer, Jayesh Kumar Sevak, Nirupama Trehanpati, Syed Naqui Kazim
Previous studies have explored the role of AKT protein in anti-apoptotic/proliferative activities. However, there has been a lack of information regarding the role of Akt in association with cytoki...
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A Comparative Transcriptomic Study and Key Gene Targeting of Lamprey Gonadal Immune Response Immunol. Invest. (IF 2.8) Pub Date : 2023-12-11 Xiangting Xu, Jing Xu, Mingyue Qiu, Yang Yu, Meng Gou, Yue Pang, Qingwei Li, Peng Su
The mammalian testis and ovary possess special immunocompetence, which is central to provide protection against pathogens. However, the innate immune responses to immune challenges in lamprey gonad...
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Resistin – A Plausible Therapeutic Target in the Pathogenesis of Psoriasis Immunol. Invest. (IF 2.8) Pub Date : 2023-12-06 Manupati Srikanth, Mahaboobkhan Rasool
Resistin, a cytokine hormone predominantly secreted by adipose tissue, is elevated in various metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease. In addition to its in...
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The Mechanistic Target of Rapamycin Complex 1 Pathway Contributes to the Anti-Tumor Effect of Granulocyte-Macrophage-Colony-Stimulating Factor-Producing T Helper Cells in Mouse Colorectal Cancer Immunol. Invest. (IF 2.8) Pub Date : 2023-12-05 Hongjian Zhou, Bin Jiang, Yuyuan Qian, Chao Ke
The role of granulocyte-macrophage-colony-stimulating factor-producing T helper (ThGM) cells in colorectal cancer (CRC) development remains unclear. This study characterizes the function of ThGM ce...
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A State-of-the-Art Review on the Recent Advances of Mesenchymal Stem Cell Therapeutic Application in Systematic Lupus Erythematosus Immunol. Invest. (IF 2.8) Pub Date : 2023-11-30 Farshid Karimi, Babak Nejati, Fatemeh Rahimi, Vahid Alivirdiloo, Iraj Alipourfard, Ali Aghighi, Alireza Raji-Amirhasani, Majid Eslami, Ali Babaeizad, Farhood Ghazi, Akram Firouzi Amandi, Mehdi Dadashpour
Systemic lupus erythematosus (SLE) is an autoimmune disease with an unknown etiology that has widespread clinical and immunological manifestations. Despite the increase in knowledge about the patho...
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CAR-T Therapy Targets Extra Domain B of Fibronectin Positive Solid Tumor Cells Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Jie Tang, Nan Liu, Yongjie Zhu, Yi Li, Xudong Zhao
CAR-T cell immunotherapy has achieved remarkable success in malignant B-cell malignancies, but progress in solid tumors is slow, and one of the key reasons is the lack of ideal targets. Cancer-spec...
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The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Yu Dai, Xuemin Zhang, Yao Xu, Ya Wu, Liqi Yang
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive intracellular lipid accumulation, oxidative stress, and inflammation. Cinnamyl alcohol (CA), one of the cinnamon extracts, has...
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Immunological Assessment of Recent Immunotherapy for Colorectal Cancer Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Subhadeep Das, Diptikanta Acharya
Colorectal cancer (CRC) is the third most prevalent malignancy with increased incidence and mortality rates worldwide. Traditional treatment approaches have attempted to efficiently target CRC; how...
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Dengue Vaccination: Towards a New Dawn of Curbing Dengue Infection Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Sidhant Jain, Neha Vimal, Nilza Angmo, Madhumita Sengupta, Suraj Thangaraj
Dengue is an infectious disease caused by dengue virus (DENV) and is a serious global burden. Antibody-dependent enhancement and the ability of DENV to infect immune cells, along with other factors...
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Immunological Regulation of Gut-Tropic Immune Cells by Extracellular Vesicles Immunol. Invest. (IF 2.8) Pub Date : 2023-11-21 Yasunari Matsuzaka, Ryu Yashiro
The remarkable diversity of lymphocytes, essential components of the immune system, serves as an ingenious mechanism for maximizing the efficient utilization of limited host defense resources. Whil...
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A Crosstalk Between Castration-Resistant Prostate Cancer Cells, M2 Macrophages, and NK Cells: Role of the ATM-PI3K/AKT-PD-L1 Pathway Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Hongliang Jin, Jin Zhu, Rui Xuan, Yibin Zhou, Boxin Xue, Dongrong Yang, Jie Gao, Yachen Zang, Lijun Xu
Castration-resistant prostate cancer (CRPC) in males is associated with a poor prognosis and a higher risk of treatment-related adverse effects, with high mortality among cancers globally. It is th...
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High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Hui Lin, Lei Gao, Yu Huang
To investigate the expression of Siglec10 and CD24 in normal early pregnancy and missed abortion, and their significance in the maternal-fetal interface.For our research, we employed Q-PCR and WB t...
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Rat Experimental Autoimmune Gastritis Model Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Liubov Beduleva, Kseniya Fomina, Alexandr Sidorov, Alexey Terentiev, Pavel Ivanov, Igor Menshikov
Autoimmune gastritis (AIG) is an autoimmune disease of the stomach characterized by the destruction of the oxyntic mucosa, which stops producing acid and becomes both functionally and morphological...
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New Insights into Immune Cells and Immunotherapy for Thyroid Cancer Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Yujia Tao, Peng Li, Chao Feng, Yuan Cao
Thyroid cancer (TC) is the most common endocrine malignancy worldwide, and the incidence of TC has gradually increased in recent decades. Differentiated thyroid cancer (DTC) is the most common subt...
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Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Shelby N. Bess, Matthew J. Igoe, Timothy J. Muldoon
The immune system has evolved to detect foreign antigens and deliver coordinated responses, while minimizing “friendly fire.” Until recently, studies investigating the behavior of immune cells were...
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The Putative Effects of Neoadjuvant Chemotherapy on the Immune System of Advanced Epithelial Ovarian Carcinoma Immunol. Invest. (IF 2.8) Pub Date : 2023-11-21 Yunyun Li, Xiaoling Gan, Fei Li, Lina Hu
The epithelial ovarian carcinoma (EOC) is one of leading causes of cancer-related mortality in females. For some patients, complete resection cannot be achieved, thus neoadjuvant chemotherapy (NACT...
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Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma Immunol. Invest. (IF 2.8) Pub Date : 2023-11-24 Farsaneh Sadeghlar, Julia Seelemann, Annabelle Vogt, Christian Möhring, Taotao Zhou, Robert Mahn, Miroslaw Kornek, Veronika Lukacs-Kornek, Noelia Casares, Juan José Lasarte, Pablo Sarobe, Cornelius van Beekum, Hanno Matthaei, Steffen Manekeller, Jörg Kalff, Ingo G.H. Schmidt-Wolf, Christian P. Strassburg, Maria A. Gonzalez-Carmona
Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepatocellular carcinoma. However, clinical response has been shown to be limited. High re...
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Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses Immunol. Invest. (IF 2.8) Pub Date : 2023-11-19 Pearl A. Sutter, Erica R. Lavoie, Evan T. Lombardo, Meghan K. Pinter, Stephen J. Crocker
Astrocyte-derived extracellular vesicles (ADEVs) have garnered attention as a fundamental mechanism of intercellular communication in health and disease. In the context of neurological diseases, fo...
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MicroRNA-Mediated Antiproliferative Effects of M1 Macrophage-Derived Extracellular Vesicles on Melanoma Cells Immunol. Invest. (IF 2.8) Pub Date : 2023-11-19 Najla Adel Saleh, Michele Patrícia Rode, Júlia Cisilotto, Adny Henrique Silva, Anne Natalie Prigol, Fernanda da Luz Efe, Evelyn Winter, Fabíola Branco Filippin-Monteiro, Tânia Beatriz Creczynski-Pasa
Research in tumor treatment has shown promising results using extracellular vesicles (EVs) derived from immune cells. EVs derived from M1 macrophages (proinflammatory), known as M1-EVs, have proper...
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EGR-1 Contributes to Pulmonary Edema by Regulating the Epithelial Sodium Channel in Lipopolysaccharide-Induced Acute Lung Injury Immunol. Invest. (IF 2.8) Pub Date : 2023-09-21 Song Wang, Jing Ma, Xin Li, Xinmiao Xian, Guikun Tan, Hongwei Cai, Bingwu Yang, Anqi Zhang, Jianran Guo, Guohao Gu, Zhen Meng, Bo Fu
Acute lung injury (ALI) is a common lung disease with increasing morbidity and mortality rates due to the lack of specific drugs. Impaired alveolar fluid clearance (AFC) is a primary pathological f...
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Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model Immunol. Invest. (IF 2.8) Pub Date : 2023-09-04 Alexandre Kleber Silveira, Henrique Mautone Gomes, Nicole Thais. Fröhlich, Luana Possa, Lucas Santos, Flávio Kessler, Alberto Martins, Matheus Scarpatto Rodrigues, Jade De Oliveira, Natália Duarte do Nascimento, Dienifer Sirena, Ana Helena Paz, Daniel Pens. Gelain, José Cláudio Fonseca Moreira
Inflammatory bowel diseases (IBD) cause increased inflammatory signalling and oxidative damage. IBDs are correlated with an increased incidence of brain-related disorders suggesting that the gut-br...
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The Impact of Tumor-Associated Macrophages Found at Mammary Carcinoma Sites is Dependent Upon the Tumor Type Immunol. Invest. (IF 2.8) Pub Date : 2023-08-30 Musea Chang, Katherine Ellmaker, Abigail Esposito, Amanda Lauricella, Sophea Pa, Meghan Roberts, Robert A. Kurt
Previously, we reported that tumor-associated macrophages (TAM) at early sites of mammary carcinoma showed a decrease in ATP production rate and a higher dependence on oxidative phosphorylation.Sin...
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Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status Immunol. Invest. (IF 2.8) Pub Date : 2023-08-29 Chen Liu, Yiying Wang, Ya-Hui Zhang, Zihang Yuan, Zhonghui Zhang, Xingyue Zeng, Zhao Guan, Ayibaota Bahabayi, Songsong Lu
To investigate the expression of layilin (LAYN) in human circulating monocytes and lymphocytes and its clinical significance in systemic lupus erythematosus (SLE).Blood samples were collected from ...
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Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes Immunol. Invest. (IF 2.8) Pub Date : 2023-08-24 Adam Slavick, Victoria Furer, Ari Polachek, Reut Tzemach, Ori Elkayam, Smadar Gertel
Monocytes are innate immune cells that play a dual role in protection of host against pathogens and initiation and perpetuation of inflammatory disorders including joint diseases. During inflammati...
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Regulatory Rheumatoid Factor is Specific to PD-1 and Uses PD-1 Pathway to Control CD4 T Lymphocytes Immunol. Invest. (IF 2.8) Pub Date : 2023-08-24 Tatyana Khramova, Liubov Beduleva, Alexandr Sidorov, Alexey Terentiev, Igor Menshikov
We have earlier discovered a new factor of autoimmunity downregulation, called regulatory rheumatoid factor (regRF). Being anti-idiotypic antibodies, regRF restricts the expansion of CD4+ T lymphoc...
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The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer Immunol. Invest. (IF 2.8) Pub Date : 2023-08-24 Anita Chauhan, Sonam Agarwal, Marilyn Masih, Pramod Kumar Gautam
Mesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of ...
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The Cooperation of IL-29 and PLGA Nanoparticles Improves the Protective Immunity of the gD-1 DNA Vaccine Against Herpes Simplex Virus Type 1 in Mice Immunol. Invest. (IF 2.8) Pub Date : 2023-08-23 Parisa Amir Kalvanagh, Hesam Karimi, Hoorieh Soleimanjahi, Massoumeh Ebtekar, Parviz Kokhaei, Zahra Matloubi, Roghieh Rahimi, Nazanin Atieh Kazemi-Sefat, Hajar Rajaei
In clinical practice, the low immunogenicity and low stability of the DNA plasmid vaccine candidates are two significant shortcomings in their application against infectious diseases. To overcome t...
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Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc Immunol. Invest. (IF 2.8) Pub Date : 2023-08-14 Xuelin Men, Wei Zhu
Perilipin 3 (PLIN3), a lipid droplet-associated protein, is found to be highly expressed in human cancers. This study aimed to investigate the biological functions and underlying mechanism of PLIN3...
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Human Leukocyte Antigen Polymorphism HLA-A*24:02 is Associated with Acute Liver Disease in HBV-Infected Han Chinese Adults Immunol. Invest. (IF 2.8) Pub Date : 2023-07-07 Dongliang Li, Zhiyu Zeng, Shumin Zhao, Xiulan Ao, Haicong Wu, Zhiqiang Zhang, Shian Zhang, Xiaolin Zhou, Xiaohui Miao
ABSTRACT Background Whether polymorphic Human Leukocyte Antigen (HLA)-A, HLA-B and HLA-DRB1 alleles were associated with acute liver disease after hepatitis B virus (HBV) infections was investigated. Methods In this study, from initially 100 participants in each group, HLA-A, HLA-B and HLA-DRB1 sequences were available from 86 acute hepatitis B (AHB) patients and from 84 HBV-resistant individuals (controls)
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HGF-Based CAR-T Cells Target Hepatocellular Carcinoma Cells That Express High Levels of c-Met Immunol. Invest. (IF 2.8) Pub Date : 2023-07-06 Haiyan Ma, Wenwen Wei, Dandan Liang, Xing Xu, Dong Yang, Qiong Wang, Yun Wang, Quan Wei, Bin Sun, Xudong Zhao
ABSTRACT Background CAR-T is emerging as an effective treatment strategy for hematologic malignancies, however its effectiveness for treating solid tumors, such as Hepatocellular Carcinoma (HCC) is limited. Here, we screened a variety of CAR-T cells that target c-Met to investigate their potential to induce HCC cell death in vitro. Methods Human T cells were transduced to express CARs by lentiviral
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Combination of PD-1 Checkpoint Blockade and Botulinum Toxin Type A1 Improves Antitumor Responses in Mouse Tumor Models of Melanoma and Colon Carcinoma Immunol. Invest. (IF 2.8) Pub Date : 2023-07-05 Seongsung Kwak, Ji-Young Lee, Min Ju Kim, Hyo Jin Lee, Dong-Kyu Lee, Jiyeon Kang, Won-ho Kang, Woo-Chan Son, Deu John M. Cruz
ABSTRACT Background Tumor innervation has been shown to be utilized by some solid cancers to support tumor initiation, growth, progression, and metastasis, as well as confer resistance to immune checkpoint blockade through suppression of antitumor immunologic responses. Since botulinum neurotoxin type A1 (BoNT/A1) blocks neuronal cholinergic signaling, its potential use as an anticancer drug in combination
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Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11 Immunol. Invest. (IF 2.8) Pub Date : 2023-07-04 Wenjing Ye, Qian Wang, Li Zhao, Changcheng Wang, Dandan Zhang, Mengyu Zhou, Fangfang Chen, Weiguo Wang, Zaihua Zhu, Wenyu Guo, Yun Liu, Hejian Zou, Yu Xue
ABSTRACT Objectives Systemic sclerosis (SSc) is a rare rheumatic disease characterized by vascular damage, dysregulated immune response, and fibrosis. Interleukin−11 (IL−11) is upregulated in SSc. This study aimed to investigate the pathological and therapeutic role of the IL−11 trans-signaling pathway in SSc. Methods Plasma IL−11 level was evaluated in 32 patients with SSc and 15 healthy controls
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ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8 Immunol. Invest. (IF 2.8) Pub Date : 2023-06-16 Dongdong Dou, Meirong Bi, Xiuyun Li, Nan Zhang, Mi Xu, Aili Guo, Feng Li, Weiwei Zhu
ABSTRACT Background Childhood asthma is a major global health concern. ADP-ribosylation factor 6 (ARF6) is a low-molecular-weight GTPase; however, its role in childhood asthma remains unclear. Methods Ovalbumin (OVA)-challenged neonatal mice and transforming growth factor-β1 (TGF-β1)-induced BEAS-2B cells were used as in vivo and in vitro models of childhood asthma, respectively. Results Upon OVA stimulation
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Bone Marrow Stromal Cell-Secreted Extracellular Vesicles Containing miR-34c-5p Alleviate Lung Injury and Inflammation in Bronchopulmonary Dysplasia Through Promotion of PTEN Degradation by Targeting OTUD3 Immunol. Invest. (IF 2.8) Pub Date : 2023-06-13 Xiao He, Juan Kuang, Yijing Wang, Guofeng Lan, Xuekai Shi
ABSTRACT Background: Bronchopulmonary dysplasia (BPD) is the predominant chronic disorder in preterm neonates. This study explored impacts of miR-34c-5p carried by bone marrow stromal cells-secreted extracellular vesicles (BMSC-EVs) on BPD progression.Methods: A BPD mouse model was established, followed by measurement of miR-34c-5p, OTUD3, and PTEN expression. EVs were isolated from BMSCs transfected
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MicroRNA-211 Regulates Proliferation, Expansion, and Immune Inhibitory Function of Myeloid-Derived Suppressor Cells via Mediation of CHOP Expression Immunol. Invest. (IF 2.8) Pub Date : 2023-06-13 Li-e Zheng, Min Huang, Yuhong Ye, Pengming Sun
ABSTRACT Background Myeloid-derived suppressor cells (MDSCs) are capable of effectively repressing immune responses against tumors and orchestrating the tumor microenvironment, which can promote tumor angiogenesis and metastasis. The pathway networks used to modulate tumor-expanded MDSC accumulation and function remain unclear. This study identified microRNA-211 (miR-211), whose expression was significantly
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Automated Analysis of PD1 and PDL1 Expression in Lymph Nodes and the Microenvironment of Transmissible Tumors in Tasmanian Devils Immunol. Invest. (IF 2.8) Pub Date : 2023-06-02 Grace G. Russell, Chiara Palmieri, Jocelyn Darby, Gary P. Morris, Nicholas M. Fountain-Jones, Ruth J. Pye, Andrew S. Flies
ABSTRACT The wild Tasmanian devil (Sarcophilus harrisii) population has suffered a devastating decline due to two clonal transmissible cancers. The first devil facial tumor 1 (DFT1) was observed in 1996, followed by a second genetically distinct transmissible tumor, the devil facial tumor 2 (DFT2), in 2014. DFT1/2 frequently metastasize, with lymph nodes being common metastatic sites. MHC-I downregulation
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Study of NLRP3 Single Nucleotide Polymorphisms in Juvenile Systemic Lupus Erythematosus (JSLE) Immunol. Invest. (IF 2.8) Pub Date : 2023-06-01 Niloufar Yazdanpanah, Arezou Rezaei, Vahid Ziaee, Nima Rezaei
ABSTRACT Juvenile systemic lupus erythematosus (JSLE) is a multifaceted multifactorial disorder with an unclear etiopathogenesis. Environmental factors, genetic factors, and dysregulated and defective immune system responses are known to have a role in JSLE etiopathogenesis. NLRP3 inflammasome, as an important contributor to immune-mediated inflammatory responses, is assumed to be involved in JSLE
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TREM-1 as a Marker of Multiple Organ Failure in Cardiac Surgery Immunol. Invest. (IF 2.8) Pub Date : 2023-05-22 Maria V. Khutornaya, Maxim Yu Sinitsky, Anna V. Sinitskaya, Maxim А. Asanov, Anastasia V. Ponasenko, Evgeny V. Grigoriev
ABSTRACT Systemic inflammatory response syndrome (SIRS) frequently accompanies early postoperative period after cardiac surgery and in some cases is complicated by multiple organ failure (MOF). Inherited variation in the innate immune response genes (e.g., TREM1) is among the major factors determining the development of SIRS and the risk of MOF. This research was aimed to study whether the polymorphisms
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Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome Immunol. Invest. (IF 2.8) Pub Date : 2023-05-08 Baoshan Hu, Shan Lin, Shengrong Lin, Gang Rui
ABSTRACT Background Apoptosis, inflammation, and the extracellular matrix (ECM) synthesis and catabolism are compromised with intervertebral disc degeneration (IDD). Ginkgetin (GK) has been demonstrated to alleviate several diseases; however, its effect on IDD remains unknown. Methods The nucleus pulposus cells (NPCs) were stimulated with interleukin (IL)-1β to construct the IDD models in vitro. Rats
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NLRC3 Participates in Inhibiting the Pulmonary Inflammatory Response of Sepsis-Induced Acute Lung Injury Immunol. Invest. (IF 2.8) Pub Date : 2023-05-04 Ruiting Li, Yue Zhao, Xue Zhang, Le Yang, Xiaojing Zou
ABSTRACT Acute lung injury (ALI) progresses rapidly, is difficult to treat, and has a high fatality rate. The excessive inflammatory response is an important pathological mechanism of ALI. NLRC3 (NLR family CARD domain-containing 3), a non-inflammasome member of the NLR family, has been found that it could negatively regulates various biological pathways associated with inflammatory response, such
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Long Non Coding RNA FOXD3‑AS1 Alleviates Allergic Rhinitis by Elevating the Th1/Th2 Ratio via the Regulation of Dendritic Cells Immunol. Invest. (IF 2.8) Pub Date : 2023-05-02 Hao Zhang, Xinhua Zhu, Hongbing Liu, Chunping Yang, Yuehui Liu
ABSTRACT This article aimed to explore whether the regulation of Th1/Th2 immune responses by FOXD3-AS1 is associated with dendritic cells (DCs) in allergic rhinitis (AR). HE staining was performed to assess the pathological changes in the nasal mucosa; ELISA was performed to measure the levels of Th1/Th2-related cytokines; flow cytometry was performed to analyze Th1/Th2 cells and MHC-II-, CD80-, and
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Adipose Tissue Macrophage-Mediated Inflammation in Obesity: A Link to Posttranslational Modification Immunol. Invest. (IF 2.8) Pub Date : 2023-05-02 Dongqin Wei, Xin Tian, Xiangyun Zhai, Chao Sun
ABSTRACT Adipose tissue macrophages (ATM) are an essential type of immune cells in adipose tissue. Obesity induces the inflammation of adipose tissues, as expressed by ATM accumulation, that is more likely to become a source of systemic metabolic diseases, including insulin resistance. The process is characterized by the transcriptional regulation of inflammatory pathways by virtue of signaling molecules