-
Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down Regulation in Experimental Schistosoma mansoni Infection via Chloroquine Repurposing Parasite Immunol. (IF 2.2) Pub Date : 2024-03-18 Marwa A. Hasby Saad, Esraa G. El-Saadi, Dareen A. Ali, Mona M. Watany, Mohammed M. Eid
In previous studies, the inhibitory effect of chloroquine on NLRP3 inflammasome and heme production was documented. This may be employed as a double-bladed sword in schistosomiasis (anti-inflammatory and parasiticidal). In this study, chloroquine's impact on schistosomiasis mansoni was investigated. The parasitic load (worm/egg counts and reproductive capacity index [RCI]), i-Nos/Arg-1 expression,
-
Pyroptosis Tuning in Intestinal Cryptosporidiosis via the Natural Histone Deacetylase Inhibitor Romidepsin Parasite Immunol. (IF 2.2) Pub Date : 2024-03-18 Noha E. Shalaby, Zeinab S. Shoheib, Nabila A. Yassin, Heba H. El-Kaliny, Marwa A. Hasby Saad
Cryptosporidium is an opportunistic protozoan, with many species of cross-human infectivity. It causes life-threatening diarrhoea in children and CD4-defective patients. Despite its limited efficacy, nitazoxanide remains the primary anti-cryptosporidial drug. Cryptosporidium infects the intestinal brush border (intracellular–extracytoplasmic) and down-regulates pyroptosis to prevent expulsion. Romidepsin
-
High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis Parasite Immunol. (IF 2.2) Pub Date : 2024-03-11 Xianmo Wang, Quan Gong, Hao Nie, Jiancheng Tu, Wen Fan, Xiaoping Tan
Long‐term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results
-
LaSap vaccine: Immunotherapy and immunochemotherapy associated with allopurinol in dogs naturally infected with Leishmania infantum Parasite Immunol. (IF 2.2) Pub Date : 2024-02-23 Ricardo B. Clasta, Açucena Veleh Rivas, Adrieli Barboza Souza, Angelo G. V. dos Santos, Andrés Hernán Mojoli Le Quesne, Ana Alice Maia Gonçalves, Alex Sander R. Cangussu, Rodolfo C. Giunchetti, Kelvinson F. Viana
Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty‐four symptomatic and naturally infected dogs with Leishmania infantum were tested with two treatment protocols (i) immunotherapy
-
Expression of Toll‐like receptors and host defence peptides in the cecum of chicken challenged with Eimeria tenella Parasite Immunol. (IF 2.2) Pub Date : 2024-02-22 Song Wang, Danni Wang, Yilin Bai, Guijie Zheng, Yanhui Han, Lei Wang, Jianhe Hu, Huili Zhu, Yueyu Bai
Chicken coccidiosis, caused by Eimeria protozoa, affects poultry farming. Toll‐like receptors (TLRs) and host defence peptides (HDPs) help host innate immune responses to eliminate invading pathogens, but their roles in Eimeria tenella infection remain poorly understood. Herein, 14‐day‐old chickens were treated orally with 50,000 E. tenella oocysts and the cecum was dissected at different timepoints
-
TNF blockers alone and associated with Benznidazole impact in vitro cytokine dynamics in chronic Chagas disease Parasite Immunol. (IF 2.2) Pub Date : 2024-02-22 Diego José Lira Torres, Kamila Kássia dos Santos Oliveira, Michelle da Silva Barros, Leyllane Rafael Moreira, Luciane de Freitas Firmino, Maria da Piedade Costa Reis de Albuquerque, Maria da Glória Aureliano Melo Cavalcante, Sílvia Marinho Martins, Wilson Alves de Oliveira Junior, Michelle Christiane da Silva Rabello, Virginia Maria Barros de Lorena
Studies involving the immune response in Chagas disease suggest an imbalance in the immune response of symptomatic patients, with an inflammatory profile dominating in Chagas heart disease, mainly by tumour necrosis factor (TNF). TNF is considered a key cytokine in immunopathology in chronic carriers in several processes during the immune response. Our work aimed to evaluate regulatory (interleukin
-
Comparison of the immune response and protection against the experimental Toxoplasma gondii infection elicited by immunization with the recombinant proteins BAG1, ROP8, and BAG1‐ROP8 Parasite Immunol. (IF 2.2) Pub Date : 2024-02-19 Yien Xing, Jun Yang, Pengjing Yao, Linding Xie, Min Liu, Yihong Cai
Toxoplasmosis is one of the most dangerous zoonotic diseases, causing serious economic losses worldwide due to abortion and reproductive problems. Vaccination is the best way to prevent disease; thus, it is imperative to develop a candidate vaccine for toxoplasmosis. BAG1 and ROP8 have the potential to become vaccine candidates. In this study, rTgBAG1, rTgROP8, and rTgBAG1‐rTgROP8 were used to evaluate
-
Complement receptor 3 is required for maximum in vitro trogocytic killing of the parasite Trichomonas vaginalis by human neutrophil‐like cells Parasite Immunol. (IF 2.2) Pub Date : 2024-02-19 Emma N. Trujillo, Barbara A. Flores, Isabel V. Romero, Jose A. Moran, Aljona Leka, Ashley D. Ramirez, Jason Ear, Frances Mercer
Trichomonas vaginalis (Tv) is a parasite that causes trichomoniasis, a prevalent sexually‐transmitted infection. Neutrophils are found at the site of infection, and can rapidly kill the parasite in vitro, using trogocytosis. However, the specific molecular players in neutrophil killing of Tv are unknown. Here, we show that complement proteins play a role in Tv killing by human neutrophil‐like cells
-
Reduction in creatine metabolites in macrophages exposed to small molecule analogues of the anti‐inflammatory parasitic worm product ES‐62 Parasite Immunol. (IF 2.2) Pub Date : 2024-02-19 S. Alanazi, J. Doonan, F. E. Lumb, N. Alenzi, S. Jabbar, L. Al‐Riyami, C. J. Suckling, W. Harnett, D. G. Watson
ES‐62, a protein secreted by Acanthocheilonema viteae, is anti‐inflammatory by virtue of covalently attached phosphorylcholine (PC) residues and thus a library of drug‐like small molecule analogues (SMAs) based on its PC moieties has been designed for therapeutic purposes. Two members, SMAs 11a and 12b, were previously found to suppress production of pro‐inflammatory cytokines by mouse bone marrow‐derived
-
Understanding hypergammaglobulinemia in experimental or natural visceral leishmaniasis Parasite Immunol. (IF 2.2) Pub Date : 2024-01-25 Camila Aparecida de Carvalho, Roberto Mitsuyoshi Hiramoto, Luciana Regina Meireles, Heitor Franco de Andrade
Nonspecific hypergammaglobulinemia (HGG) occurs in symptomatic human visceral leishmaniasis (VL) caused by L. L. infantum. This study assessed this finding in experimental infection in hamsters and natural infection in dogs. The serum concentration of proteins, albumin and globulins was determined through the biuret and bromocresol green reaction, where the HGG was better expressed through the albumin/globulin
-
The effects of Fasciola hepatica recombinant proteins (peroxiredoxin and cathepsin L1) on Crohn's disease experimental model Parasite Immunol. (IF 2.2) Pub Date : 2024-01-18 Hamid Hasanpour, Reza Falak, Kobra Mokhtarian, Fatemeh Sadeghi, Elham Masoumi, Parisa Asadollahi, Alireza Badirzadeh, Sanaz Jafarpour Azami, Mohammad Davoodzadeh Gholami, Salar Pashangzadeh, Mohammad Javad Gharagozlou, Razi Naserifar, Gholamreza Mowlavi
The immunomodulatory potential of the excretory-secretory (E/S) proteins of the helminths has been shown in previous investigations. This study evaluated the effects of the recombinants and excretory-secretory proteins of the Fasciola hepatica on induced colitis in Balb/c mice. The F. hepatica Recombinant proteins, Cathepsin L1 and Peroxiredoxin, and E/S proteins were intraperitoneally injected into
-
Activation of murine macrophages by membrane proteins from Tritrichomonas foetus grown on iron- and calcium-rich conditions Parasite Immunol. (IF 2.2) Pub Date : 2024-01-10 Antonio Euan-Canto, Julio César Torres-Romero, María Elizbeth Alvarez-Sánchez, Victor Ermilo Arana-Argáez, Karla Acosta-Viana, Emanuel Ceballos-Góngora, Laura Vázquez-Carrillo, Leidi Alvarez-Sánchez
Tritrichomonas foetus is a protozoan parasite that causes a venereal disease in cattle limiting reproduction by abortions and sterility. The immune response against this parasite is poorly understood. Since the iron and calcium ions are important regulators of the microenvironment of the urogenital tract in cattle, we decided to evaluate the role of these divalent cations on the antigenicity of membrane
-
Comparison of the long-term and short-term protection in mouse model of Leishmania major infection following vaccination with Live Iranian Lizard Leishmania mixed with chitin microparticles Parasite Immunol. (IF 2.2) Pub Date : 2023-11-21 Mina Noroozbeygi, Nafiseh Keshavarzian, Mostafa Haji Molla Hoseini, Sepideh Haghdoust, Farshid Yeganeh
Inducing long-term immunity is the primary goal of vaccination. Leishmanisation using non-pathogenic to human Leishmania spp. could be considered a reliable approach to immunising subjects against Leishmania infection. Here, we evaluated the long-term immune responses (14 weeks) after immunisation with either live- or killed-Iranian Lizard Leishmania (ILL) mixed with chitin microparticles (CMPs) against
-
Expression of SmATPDases 1 and 2 in Schistosoma mansoni eggs favours IL-10 production in infected individuals Parasite Immunol. (IF 2.2) Pub Date : 2023-11-03 Thalisson Artur Ribeiro Gomides, Márcio Luís Moreira de Souza, Amanda Braga de Figueiredo, Marlucy Rodrigues Lima, Alda Maria Soares Silveira, Girley Francisco Machado de Assis, Lúcia Alves Oliveira Fraga, Gabriela Silveira-Nunes, Letícia Martucci, Jennifer Delgado Garcia, Luís Carlos Crocco Afonso, Andréa Teixeira-Carvalho, Pauline Martins Leite
A role of IL-10 is down-regulating T-cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in S. mansoni eggs. Faecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines were measured in supernatants of PBMC. The analysis was performed by the global
-
Malaria sporozoites evade host complement attack Parasite Immunol. (IF 2.2) Pub Date : 2023-10-19 Shiming Jiao, Nie Tan, Chengyu Zhu, Yan Ding, Wenyue Xu
Complement is the first line of the host innate immune response against bacterial and viral infections; however, its role in the development of the malaria liver stage remains undefined. We found that sporozoite infection by either a mosquito bite or intravenous injection activated systemic complement, but neither depletion of C3 nor knockout of C3 had a significant effect on malaria liver stage development
-
Zinc status or supplementation and its relation to soil-transmitted helminthiasis in children: A systematic review Parasite Immunol. (IF 2.2) Pub Date : 2023-10-17 Sehar Iqbal, Juweria Abid, Sajeela Akram, Hassan Bin Usman Shah, Umar Farooq, Abdul Momin Rizwan Ahmad
Soil-transmitted helminths (STHs) parasitic infection is known as one of the most common infections around the world affecting more than a quarter of the world's population. The relationship between STH infections and micronutrient deficiencies are closely related and often coexist among the affected population. The study, therefore, aimed to summarise the available literature focusing on the effect
-
COVID-19 associated mucormycosis surge: A review on multi-pathway mechanisms Parasite Immunol. (IF 2.2) Pub Date : 2023-10-17 Mohsen Pourazizi, Atousa Hakamifard, Alireza Peyman, Rasoul Mohammadi, Shakiba Dehghani, Najmeh Tavousi, Nastaran-Sadat Hosseini, Hamed Azhdari Tehrani, Bahareh Abtahi-Naeini
Mucormycosis is a fungal infection caused by moulds from the Mucorales order. Concerns have been mounting due to the alarming increase in severe morbidity and mortality associated with mucormycosis during the COVID-19 pandemic. This condition, known as COVID-19-associated mucormycosis (CAM), has been linked to various environmental, host-related, and medical factors on a global scale. We have categorized
-
A multimodality therapeutic application on Toxoplasma gondii encephalitis utilizing Spiramycin and ‘de novo’ Ferula asafetida in immunodeficient mice Parasite Immunol. (IF 2.2) Pub Date : 2023-10-09 Badria Hassan Almurshidi, Zeinab Fahmy, Amal El-Shennawy, Eman A. H. Selim, Olfat Ali Hammam, Hend Okasha, Wissam Al-Hajj, Salma Awad Mahmoud, Gehan Labib Abuelenain
This study investigated a ‘de Novo’ medicinal herb, Ferula asafetida (FA), against toxoplasma encephalitis either alone or combined with spiramycin (SP). Female Swiss-Webster mice (n = 72) were divided into three batches. Batch-I received no DMS to serve as an immunocompetent control, batch-II was immune-suppressed with the DMS (0.25 mg/g/day) for 14 days pre-infection, whilst batch-III was immune-suppressed
-
Biomarkers for the diagnosis, treatment follow-up, and prediction of cardiac complications in Chagas disease in chronic phase: Recent advances Parasite Immunol. (IF 2.2) Pub Date : 2023-10-05 Mateo Morales-Velásquez, Juan Pablo Barón-Vera, María Isabel Osorio-Pulgarín, Miryan Margot Sánchez-Jiménez, Juan David Ospina-Villa
Chagas disease is caused by the Trypanosoma cruzi parasite and is transmitted by infected triatomine bugs. This infection affects approximately 8 million people in the Americas, and due to globalisation and displacement, it is becoming increasingly common to find infected patients worldwide. Diagnosis of the disease in its acute form is relatively simple, as the parasite can be detected in peripheral
-
Human neutrophil-like cells demonstrate antimicrobial responses to the chronic cyst form of Toxoplasma gondii Parasite Immunol. (IF 2.2) Pub Date : 2023-09-30 Kristina V. Bergersen, Ashley D. Ramirez, Bill Kavvathas, Frances Mercer, Emma H. Wilson
The protozoan parasite Toxoplasma gondii infects approximately 2.5 billion people worldwide. Infection induces a rapid dissemination of parasites throughout the body followed by the formation of lifelong cysts within neurons of the host brain. Both stages require a dynamic immune response comprised of both innate and adaptive cells. Neutrophils are a primary responding cell to acute infection and have
-
The immunomodulatory effects of the C-type lectin protein of Toxocara canis on experimental autoimmune encephalomyelitis Parasite Immunol. (IF 2.2) Pub Date : 2023-09-18 Fazeleh Etebar, Seyed Hossein Hosseini, Mehdi Borhani Zarandi, Abdorreza Naser Moghadasi, Fateme Jalousian
Toxocara canis is a global zoonosis infection that can cause chronic and long-term toxocariasis in their paratenic host. The excretory-secretory (ES) products of T. canis larvae are considered to be responsible for the Th2 polarization and regulatory immune responses in toxocariasis. The C-type lectin family is one of the most prominent components of ES products of T. canis infective larvae. This study
-
When the adrenals alert us to a systemic fungal disease Parasite Immunol. (IF 2.2) Pub Date : 2023-08-23 Daniel Alvarenga Fernandes, Mariângela Ribeiro Resende, Acsa Caroline Mesquita da Silva, André Almeida Schenka, Icléia Barreto, Fabiano Reis
We present a patient referred for investigation of adrenal insufficiency, confirmed due to disseminated paracoccidioidomycosis (PCM), with abdominal and central nervous system (CNS) involvement. Establishing the pathogenesis and immunological processes involved in chronic or latent infections by PCM has been challenging. Medical doctors caring for patients with immunodeficiencies should learn about
-
Unfolded protein response pathway in leishmaniasis: A review Parasite Immunol. (IF 2.2) Pub Date : 2023-08-11 Nimesha Madhushani Edirisinghe, Nuwani Harshamali Manamperi, Vishmi Samudika Wanasinghe, Nadira Karunaweera
Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some
-
Characteristics of peripheral lymphocyte subsets in patients with different stages of schistosomiasis japonica Parasite Immunol. (IF 2.2) Pub Date : 2023-08-07 Zhaoqin Zhou, Junhui Li, Jie Jiang, Yulin Luo, Ming Yingzi
Immune cells are important for the development of schistosomiasis japonica and are also critical for the treatment of schistosomiasis. The immune cells in the peripheral blood help assess the immune state. The peripheral lymphocytes in schistosomiasis mansoni were well studied; however, immune cells in patients with different stages of schistosomiasis japonica are not well analysed. Here, we performed
-
Dot-ELISA based on recombinant Hypodermin C of Przhevalskiana silenus for field diagnosis of goat warble fly infestation Parasite Immunol. (IF 2.2) Pub Date : 2023-07-31 Vikas Yadav, Shafiya Imtiaz Rafiqi, Anish Yadav, Anand Kushwaha, Rajesh Godara, Rajesh Katoch, Rosario Panadero-Fontán
Goat warble fly infestation (GWFI) is an economically important myiasis caused by larvae of Przhevalskiana silenus (Diptera, Oestridae), prevalent in countries of the Mediterranean Basin and Indian subcontinent. GWFI is characterized by the presence of subcutaneous warbles at the lumbar and sacral region of dorsum in the infested animal. The early larval instars (L1 and L2) remain inaccessible to physical
-
Dogs with canine visceral leishmaniasis have a boost of extracellular vesicles and miR-21-5p up-expression Parasite Immunol. (IF 2.2) Pub Date : 2023-07-20 Allecineia Bispo da Cruz, Francieli Marinho Carneiro, Marta Marques Maia, Ingrid de Siqueira Pereira, Noemi Nosomi Taniwaki, Gislene Mitsue Namiyama, Ricardo Gava, Roberto Mitsuyoshi Hiramoto, Vera Lucia Pereira-Chioccola
This retrospective cohort study analysed extracellular vesicles (EVs) and microRNAs (miRNAs) excreted in canine sera from dogs with canine visceral leishmaniasis (CanVL). A total of 56 canine sera were divided into Group I (28, from healthy dogs) and Group II (28, from the same dogs, but already with CanVL). CanVL was determined by clinical and laboratory diagnoses. Canine sera were ultra-centrifuged
-
Ursolic acid-rich extract presents trypanocidal action in vitro but worsens mice under experimental acute Chagas disease Parasite Immunol. (IF 2.2) Pub Date : 2023-07-19 Maiara A. Daga, Scheila T. Nicolau, Juliana Jurumenha-Barreto, Lucas B. S. Lima, Isaac L. Cabral, Ana Paula Pivotto, Amanda Stefanello, João P. A. Amorim, Jaqueline Hoscheid, Edson A. Silva, Thaís S. Ayala, Rafael A. Menolli
Chagas disease is a neglected tropical disease with only two drugs available for treatment and the plant Cecropia pachystachya has several compounds with antimicrobial and anti-inflammatory activities. This study aimed to evaluate a supercritical extract from C. pachystachya leaves in vitro and in vivo against Trypanosoma cruzi. A supercritical CO2 extraction was used to obtain the extract (CPE). Cytotoxicity
-
Investigation of haematological, inflammatory and immunological response in naturally infected cattle with Theileria annulata Parasite Immunol. (IF 2.2) Pub Date : 2023-07-17 Mustafa Sinan Aktas, Emre Eren, Sefa Kucukler, Muhammed Sertac Eroglu, Murat Ilgun, Kerim Emre Yanar, Omer Aydin
In this study, we aimed to investigate haematological, pro-inflammatory, inflammatory, anti-inflammatory and immunological responses in naturally Theileria annulata-infected cattle. The study material consisted of 25 Simmental cattle, 2–4 years of age, one of which was a control group consisting of healthy animals (Control group, n = 10), and the other was a Theileria group that include animals positive
-
Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris Parasite Immunol. (IF 2.2) Pub Date : 2023-07-06 Shuchi Smita, Lauren M. Webb, Bridget Mooney, Simon P. Früh, Oyebola O. Oyesola, Macy K. Matheson, Seth A. Peng, Elia D. Tait Wojno
Intestinal helminth infection promotes a Type 2 inflammatory response in resistant C57BL/6 mice that is essential for worm clearance. The study of inbred mouse strains has revealed factors that are critical for parasite resistance and delineated the role of Type 1 versus Type 2 immune responses in worm clearance. In C57BL/6 mice, basophils are key innate immune cells that promote Type 2 inflammation
-
Enhanced mucosal response in sheep harbouring βA beta-globin against haemonchosis Parasite Immunol. (IF 2.2) Pub Date : 2023-07-03 Cintia Hiromi Okino, Simone Cristina Méo Niciura, Paula Roberta Giaretta, Gláucia Roberta Melito, Rafaela Tami Ikeda Kapritchkoff, Isabella Barbosa dos Santos, Raquel Rubia Rech, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Ana Carolina de Souza Chagas
Association between ovine β-globin polymorphisms and resistance against haemonchosis was described and related to the mechanism of high oxygen affinity βA ➔ βC switch during anaemia, but there are no studies regarding the involved local host responses. Phenotypic parameters and local responses were evaluated in sheep from two β-globin haplotypes naturally infected with Haemonchus contortus. Morada
-
Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK1/2 and P38 signalling pathways, glycolysis and autophagy in chickens Parasite Immunol. (IF 2.2) Pub Date : 2023-06-21 Meiyi Chen, Zha Jin, Qinqin Jin, Wei Liu, Xinxin Gao, Hongrong Hong, Yuxiao Qian, Yuqian Jiang, Quan Liu, Zhengkai Wei
Toxoplasma gondii is a zoonotic parasite with a global distribution. Heterophil extracellular traps (HETs) are a novel innate immune mechanism of chickens against pathogens, but whether T. gondii can induce HETs release in chickens has not been reported. The effects of T. gondii on heterophils viability were assessed by using Cell Counting Kit-8. T. gondii-induced HETs were observed and analysed by
-
Inflammatory responses during trichomoniasis: The role of Toll-like receptors and inflammasomes Parasite Immunol. (IF 2.2) Pub Date : 2023-06-20 Abdollah Jafarzadeh, Maryam Nemati, Ehsan Salarkia, Sonal Yadav, Najmeh Aminizadeh, Sara Jafarzadeh, Manisha Yadav
Toll-like receptors (TLRs) and inflammasomes belong to the pattern recognition receptors (PRRs) of innate immunity identifying conserved compounds produced by pathogens or discharged by injured cells. Different cell subsets in the human urogenital system, such as epithelial cells and infiltrating leukocytes, express different kinds of TLRs (such as TLR2, TLR3, TLR4, TLR5 and TLR9) as well as inflammasomes
-
The mouse model of chronic asthma: Airway remodelling and disease exacerbation by somatic antigen of Echinococcus granulosus Parasite Immunol. (IF 2.2) Pub Date : 2023-06-09 Sara Ghabdian, Sima Parandeh Shirvan, Mohsen Maleki, Hassan Borji
There is now sufficient evidence to support an inverse association between helminth infection and secreted products with allergic/autoimmune disorders. Accordingly, several experimental studies have shown that Echinococcus granulosus infection and hydatid cyst compounds are able to suppress immune responses in allergic airway inflammation. This is the first study on effects of somatic antigens of E
-
Oral administration of helminth fluid modulates distinct tuft cell and immune-metabolic cues linked to reduced body fat Parasite Immunol. (IF 2.2) Pub Date : 2023-06-06 Daniel Andersen, Janne Marie Moll, Pankaj Arora, Niels Banhos Danneskiold-Samsøe, Si Brask Sonne, Christopher Thomas Workman, Andrew Richard Williams, Karsten Kristiansen, Susanne Brix
Intestinal tuft cells have been shown to induce type 2 immune responses during viable parasite infections, but whether oral supplementation with a parasitic exudate is able to promote type 2 immune responses that have been shown to positively regulate obesogenic metabolic processes is yet unresolved. High-fat fed mice were gavaged with pseudocoelomic fluid (PCF) derived from the helminth Ascaris suum
-
Development of a novel immunoFET technology-based POC assay for detection of Leishmania donovani and Leishmania major Parasite Immunol. (IF 2.2) Pub Date : 2023-05-15 Nebiye Yentur Doni, Paul J. Bertani, Greta Volpedo, Noushin Saljoughian, Sanjay Varikuti, Greg Matlashewski, Wu Lu, Abhay R. Satoskar
Leishmaniasis is considered as one of the 20 neglected tropical diseases. Current methods of leishmanial diagnosis depend on conventional laboratory-based techniques, which are time-consuming, costly and require special equipment and trained personnel. In this context, we aimed to provide an immuno field effect transistors (ImmunoFET) biosensor that matches the conventional standards for point-of-care
-
Plasmodium infection and dysbiosis: A new paradigm in the host–parasite interaction Parasite Immunol. (IF 2.2) Pub Date : 2023-04-24 Nuning Winaris, Aulia Rahmi Pawestri, Syafiatul Azizah, Lustyafa Inassani Alifia, Rokhmatul Asiyah, Tita Rachma Ayuningtyas, Loeki Enggar Fitri, Teguh Wahju Sardjono
The mucosal immune system contributes for the largest component of the tissue immune system due to its massive surface area and constant exposure to the microbiota. The gut microbiota comprises a complex micro-ecosystem in the intestine and plays a major role in regulating innate and adaptive immunity. Several studies revealed that infectious diseases involve bidirectional interactions in the gut microenvironment
-
Human immune response against filarial HSP70 and its role in the diagnosis of lymphatic filariasis Parasite Immunol. (IF 2.2) Pub Date : 2023-04-18 Faiyaz Ahmad, Eva Liebau, Sushma Rathaur
A sensitive and specific diagnostic kit is crucial for the detection of human lymphatic filariasis at the early stage of infection as the existing diagnostic tools are inefficient and expensive. In the present study, we have cloned and expressed Brugia malayi HSP70 (BmHSP70) protein and characterized it as a potential antigen for diagnosis of the asymptomatic microfilariae stage of Wuchereria. bancrofti
-
Benzonidazole treatment has a beneficial effect on cells infected with the Colombian strain of Trypanosoma cruzi Parasite Immunol. (IF 2.2) Pub Date : 2023-04-17 Leyllane Rafael Moreira, Kamila Kássia dos Santos Oliveira, Diego José Lira Torres, Michelle da Silva Barros, Tiago Ribeiro de Arruda, Amanda Vasconcelos Nascimento, Ana Karine Araújo Soares, Taciana Mirely Maciel Higino, George Tadeu Nunes Diniz, Valdênia Maria Oliveira Souza, Clarice Neuenschwander Lins de Morais, Virginia Maria Barros de Lorena
Benznidazole (Bz) is the recommended drug for the treatment of Chagas disease; however, its efficacy may vary according to the sensitivity of Trypanosoma cruzi strains to the drug and host immune background. The study evaluated the immune response of peripheral blood mononuclear cells (PBMC) that were infected in vitro with the Colombian strain (Col) and treated with Bz. The co-cultures were incubated
-
The abundance and morphology of human large intestinal goblet and tuft cells during chronic schistosomiasis Parasite Immunol. (IF 2.2) Pub Date : 2023-04-11 Matthew B. Gologorsky, Claire M. Mechler, Erna Forgó, Gregory W. Charville, Michael R. Howitt
Schistosomiasis affects nearly 240 million people in predominately low- and middle-income countries and ranks second in the number of cases and socio-economic burden among all parasitic diseases. Despite the enormous burden posed by schistosomes, our understanding of how schistosomiasis impacts infected human tissues remains limited. Intestinal schistosomiasis in animal models leads to goblet cell
-
Immunological interactions in helminths-SARS CoV-2 coinfection: Could old enemy be a friend today? Parasite Immunol. (IF 2.2) Pub Date : 2023-04-11 Mohammed Alrouji, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Heba Elhadad, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Ahmed M. Elgazzar, Gaber El-Saber Batiha
Helminths are metazoan parasites affecting about one third of the worldwide population. Chronic helminth infections (CHIs) confer immunological tolerance to harmless and self-antigens mediated by regulatory T cells (Treg) that are up-regulated. In coronavirus disease 2019 (COVID-19), abnormal adaptive immune response and unrestrained innate immune response could result in local and systemic immune-mediated
-
CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis Parasite Immunol. (IF 2.2) Pub Date : 2023-03-27 I. O. Onkanga, H. Sang, R. Hamilton, B. N. Ondigo, W. Jaoko, M. R. Odiere, L. Ganley-Leal
We demonstrate that CD193, the eotaxin receptor, is highly expressed on circulating B cells in paediatric schistosomiasis mansoni. CD193 plays a role in directing granulocytes into sites of allergic-like inflammation in the mucosa, but little is known about its functional significance on human B cells. We sought to characterize CD193 expression and its relationship with S. mansoni infection. We found
-
-
Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis Parasite Immunol. (IF 2.2) Pub Date : 2023-03-08 Alex Bruno da Silva Souza, Joelma Nascimento De Souza, Cíntia de Lima Oliveira, Nilo Manoel Pereira Vieira Barreto, Wéslei Almeida Costa, Ricardo Riccio Oliveira, Márcia Cristina Aquino Teixeira, Neci Matos Soares
Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines (IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-15 and IL-17), and its correlation with modulation of parasitic
-
Modulation of haematopoiesis by protozoal and helminth parasites Parasite Immunol. (IF 2.2) Pub Date : 2023-02-16 Kyle T. Cunningham, Kingston H. G. Mills
During inflammation, haematopoietic stem cells (HSCs) in the bone marrow (BM) and periphery rapidly expand and preferentially differentiate into myeloid cells that mediate innate immune responses. HSCs can be directed into quiescence or differentiation by sensing alterations to the haematopoietic niche, including cytokines, chemokines, and pathogen-derived products. Most studies attempting to identify
-
Worms and gut microbes-Best of frenemies. Parasite Immunol. (IF 2.2) Pub Date : 2023-02-17 Cinzia Cantacessi
-
Circulatory cytokines during the piroplasm stage of natural Theileria annulata infection in cattle Parasite Immunol. (IF 2.2) Pub Date : 2023-01-29 Kenan Çağrı Tümer, Meltem Kızıl
The objective of the present study was to investigate the inflammatory and anti-inflammatory cytokine response from a broad perspective in cattle with natural Theileria annulata infection. Ten cattle naturally infected with T. annulata and eight healthy cattle were included in this study. A total of 11 cytokines, including tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-1β
-
Fungal pathogens: The underappreciated parasites that are now in the spotlight. Parasite Immunol. (IF 2.2) Pub Date : 2023-02-01 Peter C Cook,Rebecca A Drummond
-
-
Role of antigen-presenting cells in non-ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi Parasite Immunol. (IF 2.2) Pub Date : 2023-01-25 Carmen M. Sandoval Pacheco, Gabriela V. Araujo Flores, Aurea F. Ferreira, Vânia L. R. da Matta, Claudia M. de Castro Gomes, Wilfredo H. Sosa-Ochoa, Concepción Zúniga, Fernando T. Silveira, Carlos E. P. Corbett, Márcia D. Laurenti
In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen-presenting cells in skin lesions of patients affected by NUCL through double-staining immunohistochemistry using cellular and intracellular markers. Twenty-three skin biopsies
-
The role of the host gut microbiome in the pathophysiology of schistosomiasis Parasite Immunol. (IF 2.2) Pub Date : 2023-01-19 Klara A. Stark, Gabriel Rinaldi, Alba Cortés, Alice Costain, Andrew S. MacDonald, Cinzia Cantacessi
The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg-induced granulomas is the result of finely regulated crosstalk between egg-secreted antigens and host immunity, evidence
-
Case of concurrence of bullous pemphigoid and Norwegian scabies Parasite Immunol. (IF 2.2) Pub Date : 2023-01-16 Xuesong wang, Yongxia Liu, Jianke Li, Fangfang Bao, Mingfei Chen
Bullous pemphigoid (BP) with scabies is a condition rarely encountered in clinical practice, and when it is encountered, it is often due to the use of immunosuppressants. This paper is a report on a patient with BP and scabies, who developed scabs after taking dexamethasone. It should be noted that BP antibody is necessary, which can distinguish BP with scabies and bullous scabies, and the treatment
-
Host responses against the fish parasitizing ciliate Cryptocaryon irritans Parasite Immunol. (IF 2.2) Pub Date : 2023-01-06 Shuiqing Jiang, Xiaohong Huang
The parasitic ciliate Cryptocaryon irritans, which infects almost all marine fish species occurring in both tropical and subtropical regions throughout the world. The disease, cryptocaryonosis, accounts for significant economic losses to the aquaculture industry. This review attempts to provide a comprehensive overview of the biology of the parasite, host–parasite interactions and both specific and
-
Chemokine receptors on human regulatory T cells during cutaneous leishmaniasis Parasite Immunol. (IF 2.2) Pub Date : 2023-01-04 Maria Carolina Accioly Brelaz de Castro, Rafael de Freitas e Silva, Marton Kaique de Andrade Cavalcante, Larissa Layne Soares Bezerra Silva, Fabiana Oliveira Santos dos Gomes, Maria Edileuza Felinto de Brito, Valéria Rêgo Alves Pereira
The aim of this work was to define the population of regulatory T cells (Tregs) which are circulating in the blood of Leishmania infected individuals clinically displaying a lesion (active disease–AD) and sub-clinical (SC) ones. We have individually collected blood samples, processed the PBMC and stained with fluorochrome-conjugated antibodies against CD3, CD4, Foxp3, CD25, CTLA-4, Ki-67, CCR4, CCR5
-
Diet-microbiota crosstalk and immunity to helminth infection Parasite Immunol. (IF 2.2) Pub Date : 2022-12-26 Laura J. Myhill, Andrew R. Williams
Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections. Diet composition may strongly regulate gut microbiota composition and intestinal immune function and therefore
-
Organ-specific immune profiling of Leishmania donovani-infected hamsters Parasite Immunol. (IF 2.2) Pub Date : 2022-12-26 Sheetal Saini, Bharat Singh, Anuradha Dube, Amogh Anant Sahasrabuddhe, Ambak Kumar Rai
Visceral leishmaniasis (VL) is a neglected disease with a broad spectrum of clinical manifestations and involvement of visceral organs. Organ-specific immune response against the Leishmania donovani (Ld) complex is not yet understood due to the unavailability of an appropriate experimental model. In reference to our recent work on comparing the hamster model with VL patients, it is now possible to
-
Retraction Parasite Immunol. (IF 2.2) Pub Date : 2022-11-28
Retraction: Ajay Kumar, Sushmita Das, Abhishek Mandal, Sudha Verma, Kumar Abhishek, Ashish Kumar, Vinod Kumar, Ayan Kumar Ghosh, Pradeep Das (2018) Leishmania infection activates host mTOR for its survival by M2 macrophage polarization. Parasite Immunology 40(11): e12586; https://doi.org/10.1111/pim.12586
-
Retraction Parasite Immunol. (IF 2.2) Pub Date : 2022-11-25
Retraction: RajKishor Pandey, Manas Ranjan Dikhit, Avinash Kumar, Budheswar Dehury, Krishna Pandey, Roshan Kamal Topno, Pradeep Das, Sanjiva Bimal (2020) Evaluating the immunomodulatory responses of LdODC-derived MHC Class-II restricted peptides against VL. Parasite Immunology 42(4): e12699; https://doi.org/10.1111/pim.12699
-
Antifungal chemotherapies and immunotherapies for the future Parasite Immunol. (IF 2.2) Pub Date : 2022-11-20 Darius Armstrong-James
Human fungal pathogens cause a broad plethora of infections, spanning cutaneous dermatophytoses to invasive infections in immunocompromised hosts. As eukaryotic pathogens are capable of morphotype switching, they present unique challenges both for drug development and the immunological response. Whilst current antifungal therapies are limited to the orally available triazoles, intravenous echonocandins
-
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation Parasite Immunol. (IF 2.2) Pub Date : 2022-11-17 Luis E. Elizalde-Velázquez, Ivet A. Yordanova, Wjatscheslaw Liublin, Joshua Adjah, Ruth Leben, Sebastian Rausch, Raluca Niesner, Susanne Hartmann
Antibiotic treatment can lead to elimination of both pathogenic bacteria and beneficial commensals, as well as to altered host immune responses. Here, we investigated the influence of prolonged antibiotic treatment (Abx) on effector, memory and recall Th2 immune responses during the primary infection, memory phase and secondary infection with the small intestinal nematode Heligmosomoides polygyrus
-
Gastrointestinal worms and bacteria: From association to intervention Parasite Immunol. (IF 2.2) Pub Date : 2022-10-27 James Rooney, Cinzia Cantacessi, Javier Sotillo, Alba Cortés
A plethora of studies, both experimental and epidemiological, have indicated the occurrence of associations between infections by gastrointestinal (GI) helminths and the composition and function of the host gut microbiota. Given the worldwide risk and spread of anthelmintic resistance, particularly for GI parasites of livestock, a better understanding of the mechanisms underpinning the relationships