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Deep learning for detection of Fuchs endothelial dystrophy from widefield specular microscopy imaging: a pilot study Eye and Vis. (IF 4.2) Pub Date : 2024-03-18 Valencia Hui Xian Foo, Gilbert Y. S. Lim, Yu-Chi Liu, Hon Shing Ong, Evan Wong, Stacy Chan, Jipson Wong, Jodhbir S. Mehta, Daniel S. W. Ting, Marcus Ang
To describe the diagnostic performance of a deep learning (DL) algorithm in detecting Fuchs endothelial corneal dystrophy (FECD) based on specular microscopy (SM) and to reliably detect widefield peripheral SM images with an endothelial cell density (ECD) > 1000 cells/mm2. Five hundred and forty-seven subjects had SM imaging performed for the central cornea endothelium. One hundred and seventy-three
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Potential applications of artificial intelligence in image analysis in cornea diseases: a review Eye and Vis. (IF 4.2) Pub Date : 2024-03-07 Kai Yuan Tey, Ezekiel Ze Ken Cheong, Marcus Ang
Artificial intelligence (AI) is an emerging field which could make an intelligent healthcare model a reality and has been garnering traction in the field of medicine, with promising results. There have been recent developments in machine learning and/or deep learning algorithms for applications in ophthalmology—primarily for diabetic retinopathy, and age-related macular degeneration. However, AI research
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Evaluation of a new dynamic real-time visualization 25 kHz swept-source optical coherence tomography based biometer Eye and Vis. (IF 4.2) Pub Date : 2024-03-04 Jinjin Yu, Xuanqiao Lin, Xiaomin Huang, Zhenyu Xu, Rui Ning, Kexin Li, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang
To evaluate the intraobserver repeatability and interobserver reproducibility of a newly developed dynamic real-time visualization 25 kHz swept-source optical coherence tomography (SS-OCT) based biometer (ZW-30, TowardPi Medical Technology Ltd, China) and compare its agreement with another SS-OCT based biometer (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany). Eighty-two healthy right eyes were
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An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking Eye and Vis. (IF 4.2) Pub Date : 2024-02-28 Siân R. Morgan, David P. S. O’Brart, Jinhai Huang, Keith M. Meek, Sally Hayes
Corneal cross-linking (CXL) using riboflavin and ultraviolet-A light (UVA) is a treatment used to prevent progression of keratoconus. This ex vivo study assesses the impact on CXL effectiveness, as measured by tissue enzymatic resistance and confocal microscopy, of including a pre-UVA corneal surface rinse with balanced salt solution (BSS) as part of the epithelium-off treatment protocol. Sixty-eight
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Comparison of deep learning-assisted blinking analysis system and Lipiview interferometer in dry eye patients: a cross-sectional study Eye and Vis. (IF 4.2) Pub Date : 2024-02-19 Yueping Ren, Han Wen, Furong Bai, Binge Huang, Zhenzhen Wang, Shuwen Zhang, Yaojia Pu, Zhenmin Le, Xianhui Gong, Lei Wang, Wei Chen, Qinxiang Zheng
Abnormal blinking pattern is associated with ocular surface diseases. However, blink is difficult to analyze due to the rapid movement of eyelids. Deep learning machine (DLM) has been proposed as an optional tool for blinking analysis, but its clinical practicability still needs to be proven. Therefore, the study aims to compare the DLM-assisted Keratograph 5M (K5M) as a novel method with the currently
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Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy Eye and Vis. (IF 4.2) Pub Date : 2024-02-07 Xiangjun She, Wangjing Yao, Gongyu Huang, Zhi Liang, Jin Xie, Jiwei Tao, Sulan Wu, Jianbo Mao, Yiqi Chen, Yun Zhang, Lijun Shen
To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV). A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around
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Features of optical coherence tomography angiography in age-related macular degeneration with residual fluid after three loading doses of aflibercept Eye and Vis. (IF 4.2) Pub Date : 2024-02-01 Yong-Yeon Song, Hyun-Je Seong, Jung-Tae Kim, Sung-Chul Lee, Min-Woo Lee
To identify the macular neovascularization (MNV) features in exudative age-related macular degeneration (AMD) patients who exhibited residual fluid after receiving three loading doses of aflibercept. Patients were classified into two groups: Group 1, which did not exhibit intraretinal fluid (IRF) and subretinal fluid (SRF), and Group 2, which did exhibit IRF and/or SRF. Optical coherence tomography
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Homocysteine and mitochondrial quality control in diabetic retinopathy Eye and Vis. (IF 4.2) Pub Date : 2024-01-16 Pooja Malaviya, Renu A. Kowluru
Diabetic retinopathy is a progressive disease, and one of the key metabolic abnormalities in the pathogenesis of diabetic retinopathy, mitochondrial damage, is also influenced by the duration of hyperglycemia. Mitochondrial quality control involves a coordination of mitochondrial dynamics, biogenesis and removal of the damaged mitochondria. In diabetes, these processes are impaired, and the damaged
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Inhibition of miR-542-3p augments autophagy to promote diabetic corneal wound healing Eye and Vis. (IF 4.2) Pub Date : 2024-01-03 Danling Liao, Shijia Wei, Jianzhang Hu
Autophagy has recently been shown to be critical for protecting peripheral nerve regeneration. This study explored the impact of miR-542-3p on diabetic corneal nerve regeneration and epithelial healing through the regulation of autophagy. A type 1 diabetes model was established in male mice through streptozotocin administration. Immunofluorescence staining of β-Tubulin III and sodium fluorescein staining
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Keratoconus cone location influences ocular biomechanical parameters measured by the Ocular Response Analyzer Eye and Vis. (IF 4.2) Pub Date : 2024-01-03 Phillip T. Yuhas, Maddison M. Fortman, Ashraf M. Mahmoud, Cynthia J. Roberts
Keratoconus is characterized by asymmetry in the biomechanical properties of the cornea, with focal weakness in the area of cone formation. We tested the hypothesis that centrally-measured biomechanical parameters differ between corneas with peripheral cones and corneas with central cones. Fifty participants with keratoconus were prospectively recruited. The mean ± standard deviation age was 38 ± 13
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Assessing progression limits in different grades of keratoconus from a novel perspective: precision of measurements of the corneal epithelium Eye and Vis. (IF 4.2) Pub Date : 2024-01-02 Rui Ning, Yiran Wang, Zhenyu Xu, Ingemar Gustafsson, Jiawei Li, Giacomo Savini, Domenico Schiano-Lomoriello, Yichen Xiao, Aodong Chen, Xiaoying Wang, Xingtao Zhou, Jinhai Huang
To assess repeatability and reproducibility of corneal epithelium thickness (ET) measured by a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence, Italy) in keratoconus (KC) population at different stages, as well as to determine the progression limits for evaluating KC progression. A total of 149 eyes were enrolled in this study, with 29 eyes in the forme
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PRESERFLO MicroShunt implantation versus trabeculectomy for primary open-angle glaucoma: a two-year follow-up study Eye and Vis. (IF 4.2) Pub Date : 2023-12-21 Pascal Aurel Gubser, Valentin Pfeiffer, Simon Hug, Xiao Shang, Joel-Benjamin Lincke, Nathanael Urs Häner, Martin S. Zinkernagel, Jan Darius Unterlauft
To compare the intermediate-term efficacy of PRESERFLO (PF) MicroShunt implantation with trabeculectomy (TE) in patients with primary open-angle glaucoma, focusing on longitudinal changes of functional and structural parameters. This retrospective comparative study included 104 eyes of 104 patients who underwent TE and 83 eyes of 83 patients that underwent PF implantation between January 2019 and December
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Altering chromatic aberration: how this latest trend in intraocular-lens design affects visual quality in pseudophakic patients Eye and Vis. (IF 4.2) Pub Date : 2023-12-12 Grzegorz Łabuz, Helin Güngör, Gerd U. Auffarth, Timur M. Yildirim, Ramin Khoramnia
Chromatic aberration of the eye results from the dispersion of polychromatic light at the interfaces of ocular media. An intraocular lens (IOL) based approach utilizing the diffractive-multifocal principle has been proposed for its correction, but the clinical evidence on the impact of reducing or increasing chromatic aberration on the visual quality of pseudophakic patients remains scarce. In this
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Visual and refractive outcomes after implantation of two models of trifocal intraocular lenses in eyes with previous corneal ablation to treat hyperopia Eye and Vis. (IF 4.2) Pub Date : 2023-12-07 Fernando Mayordomo-Cerdá, Julio Ortega-Usobiaga, Julio Baviera-Sabater, Rafael Bilbao-Calabuig, Fernando Llovet-Osuna, Vasyl Druchkiv, Rosario Cobo-Soriano
To assess whether a trifocal intraocular lens (IOL) with neutral spherical aberration (SA) provides better visual and refractive outcomes than a trifocal IOL with negative SA after hyperopic corneal laser ablation. This is a retrospective comparative study. Patients were classified according to the IOL implanted after cataract or clear lens phacoemulsification [group 1, PhysIOL FineVision Pod-F (negative
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Age-related changes in geometry and transparency of human crystalline lens revealed by optical signal discontinuity zones in swept-source OCT images Eye and Vis. (IF 4.2) Pub Date : 2023-12-01 Ashish Gupta, Daniel Ruminski, Alfonso Jimenez Villar, Raúl Duarte Toledo, Grzegorz Gondek, Barbara Pierscionek, Pablo Artal, Ireneusz Grulkowski
The shape and microstructure of the human crystalline lens alter with ageing, and this has an effect on the optical properties of the eye. The aim of this study was to characterise the age-related differences in the morphology and transparency of the eye lenses of healthy subjects through the optical signal discontinuity (OSD) zones in optical coherence tomography (OCT) images. We also investigated
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Efficacy of small back optic zone design on myopia control for corneal refractive therapy (CRT): a one-year prospective cohort study Eye and Vis. (IF 4.2) Pub Date : 2023-11-20 Xuewei Li, Lili Zuo, Heng Zhao, Jie Hu, Tao Tang, Kai Wang, Yan Li, Mingwei Zhao
To investigate the control effect on the axial length elongation using corneal refractive therapy (CRT) with different optical zone diameters (BOZDs). We also sought to compare the difference in higher-order aberrations (HOAs), treatment zone (TZ) size and Zernike defocus coefficient with different BOZDs and seek the optimal parameter for predicting axial elongation. This prospective cohort study included
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Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift Eye and Vis. (IF 4.2) Pub Date : 2023-11-03 Renato Ambrósio, Marcella Q. Salomão, Lorena Barros, João Batista R. da Fonseca Filho, Jaime Guedes, Alexandre Neto, Aydano P. Machado, Bernardo T. Lopes, Nelson Sena, Louise Pellegrino Gomes Esporcatte
Different diagnostic approaches for ectatic corneal diseases (ECD) include screening, diagnosis confirmation, classification of the ECD type, severity staging, prognostic evaluation, and clinical follow-up. The comprehensive assessment must start with a directed clinical history. However, multimodal imaging tools, including Placido-disk topography, Scheimpflug three-dimensional (3D) tomography, corneal
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Establishment of a novel ER-stress induced myopia model in mice Eye and Vis. (IF 4.2) Pub Date : 2023-11-01 Longdan Kang, Shin-ichi Ikeda, Yajing Yang, Heonuk Jeong, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Recent studies have indicated a strong correlation between endoplasmic reticulum (ER) stress and myopia and that eyedrops containing the ER stress inducer tunicamycin (Tm) can induce myopic changes in C57BL/6 J mice. Therefore, this study aimed to create a new myopia model using Tm eyedrops and to explore the mechanism of ER stress-mediated myopia development. Three-week-old C57BL/6 J mice were treated
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Comparison of two different orthokeratology lenses and defocus incorporated soft contact (DISC) lens in controlling myopia progression Eye and Vis. (IF 4.2) Pub Date : 2023-10-07 Na Li, Weiping Lin, Ruixue Liang, Ziwen Sun, Bei Du, Ruihua Wei
To compare axial elongation in 8–11-year-old myopes wearing orthokeratology (OK) lenses with different back optic zone diameters (BOZD), defocus incorporated soft contact (DISC) lenses, and single-vision soft contact lenses (SCLs). A total of 122 children (aged 8–11 years) with spherical equivalent refraction (SER) between − 1.00 D and − 4.00 D were enrolled in this prospective study and randomly assigned
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Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy Eye and Vis. (IF 4.2) Pub Date : 2023-10-02 Thomas A. Strong, Juan Esquivel, Qikai Wang, Paul J. Ledon, Hua Wang, Gabriel Gaidosh, David Tse, Daniel Pelaez
Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated. Several studies have identified ‘ephrin signaling’ as one of the most dysregulated pathways in the early pathophysiology of optic neuropathy with varied etiologies. Developmentally, gradients in ephrin signaling coordinate retinotopic mapping
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Rate of fractional change in corneal tomography parameters in keratoconus using a combination of predictive parameters Eye and Vis. (IF 4.2) Pub Date : 2023-10-01 Gaurav Prakash, Alex Mammen, Vishal Jhanji
To compare the rate of fractional change for multiple corneal tomographic factors in progressive keratoconus (KC). In this retrospective case series, 40 eyes (40 patients) with progressive KC (increase in central keratometry of 1.00 D or maximum keratometry of 1.50 D on two visits at least six months apart) were included. Cases with previous history of ocular surgery, poor scans, corneal scars, severe
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Correction: Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study Eye and Vis. (IF 4.2) Pub Date : 2023-09-25 Farhad Hafezi, Emilio A. Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M. Enes Aydemir, Mark Hillen
Correction: Eye and Vision (2023) 10:36 https://doi.org/10.1186/s40662-023-00354-1 After publication of this article [1], it was brought to our attention that the second author's name "Emilio de Almeida Torres-Netto" should be corrected to "Emilio A. Torres-Netto". The original publication [1] has been corrected. Hafezi F, de Torres-Netto EA, Kollros L, Lu NJ, Hafezi N, Mazzotta C, Aydemir M, Hillen
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Defocus incorporated multiple segments (DIMS) spectacle lenses increase the choroidal thickness: a two-year randomized clinical trial Eye and Vis. (IF 4.2) Pub Date : 2023-09-15 Rachel Ka Man Chun, Hanyu Zhang, Zhengji Liu, Dennis Yan Yin Tse, Yongjin Zhou, Carly Siu Yin Lam, Chi Ho To
Myopia control interventions, such as defocus incorporated multiple segments (DIMS) spectacle lenses, have been adopted in school-aged children to reduce the prevalence of myopia and its complications. This study aimed to investigate the effect of DIMS spectacle lenses on subfoveal choroidal thickness (SfChT) over a period of two years, as the choroidal response to myopic control is a crucial factor
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Functional and structural changes in the neuroretina are accompanied by mitochondrial dysfunction in a type 2 diabetic mouse model Eye and Vis. (IF 4.2) Pub Date : 2023-09-01 Christie Hang-I Lam, Bing Zou, Henry Ho-Lung Chan, Dennis Yan-Yin Tse
Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. While neural function and survival rely on proper mitochondrial function, and a growing body of literature has supported the role of mitochondrial
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Rates of infectious keratitis and other ocular surface adverse events in corneal cross-linking for keratoconus and corneal ectasias performed in an office-based setting: a retrospective cohort study Eye and Vis. (IF 4.2) Pub Date : 2023-09-01 Farhad Hafezi, Emilio de Almeida Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M. Enes Aydemir, Mark Hillen
This study aimed to compare the complication rates of epithelium-off corneal cross-linking (epi-off CXL) performed in an office-based setting with those of epi-off CXL performed in an operating room. A retrospective cohort study, comprising 501 consecutive epi-off CXL procedures, performed in a non-sterile procedure room without laminar flow ventilation at the ELZA Institute in Zurich, Switzerland
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Axial length acquisition success rates and agreement of four optical biometers and one ultrasound biometer in eyes with dense cataracts Eye and Vis. (IF 4.2) Pub Date : 2023-09-01 Pedro Tañá-Rivero, Salvador Aguilar-Córcoles, Pedro Tañá-Sanz, Santiago Tañá-Sanz, Robert Montés-Micó
To evaluate the axial length acquisition success rates and agreement between various biometric parameters obtained with different biometers in dense cataracts. Fifty-one eyes were measured using Anterion®, Argos® and IOLMaster® 700 swept-source optical coherence tomography (SS-OCT) biometers, a Pentacam® AXL partial coherence interferometry (PCI) biometer, and an OcuScan® RxP ultrasound biometer. We
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Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8 Eye and Vis. (IF 4.2) Pub Date : 2023-08-14 Patrícia Barreto, Cláudia Farinha, Rita Coimbra, Maria Luz Cachulo, Joana Barbosa Melo, Yara Lechanteur, Carel B. Hoyng, José Cunha-Vaz, Rufino Silva
Age-related macular degeneration (AMD) is a multifactorial degenerative disease of the macula. Different factors, environmental, genetic and lifestyle, contribute to its onset and progression. However, how they interconnect to promote the disease, or its progression, is still unclear. With this work, we aim to assess the interaction of the genetic risk for AMD and the adherence to the Mediterranean
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Ex vivo cultivated retinal pigment epithelial cell transplantation for the treatment of rabbit corneal endothelial dysfunction Eye and Vis. (IF 4.2) Pub Date : 2023-08-02 Chunxiao Dong, Dulei Zou, Haoyun Duan, Xiangyue Hu, Qingjun Zhou, Weiyun Shi, Zongyi Li
Stem cell therapy is a promising strategy for the treatment of corneal endothelial dysfunction, and the need to find functional alternative seed cells of corneal endothelial cells (CECs) is urgent. Here, we determined the feasibility of using the retinal pigment epithelium (RPE) as an equivalent substitute for the treatment of corneal endothelial dysfunction. RPE cells and CECs in situ were obtained
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Spatio-chromatic vision with multifocal diffractive intraocular lens Eye and Vis. (IF 4.2) Pub Date : 2023-08-01 Maria S. Millan, Laura Clavé, Aurora Torrents, Jesús Armengol, Fidel Vega
This study aims to detect alterations in the spatio-chromatic pseudophakic vision produced by multifocal diffractive intraocular lenses (IOLs) and provides a physical interpretation. In vitro characterization of the imaging performance of two diffractive IOLs: AT LISA Tri (Zeiss) and FineVision (PhysIOL) in on-bench model eye illuminated with red (R, 625 nm), green (G, 530 nm) and blue (B, 455 nm)
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Comparison of corneal aberrations from anterior segment swept source OCT versus Placido-topography combined spectral domain OCT in cataract patients Eye and Vis. (IF 4.2) Pub Date : 2023-08-01 Stefan Georgiev, Manuel Ruiss, Andreea Dana-Fisus, Rainer A. Leitgeb, Oliver Findl
To comprehensively evaluate the agreement of component corneal aberrations from the newly updated wavefront analysis software of a swept-source optical coherence tomographer (SS-OCT) and a referential Placido-topography combined OCT device in elderly cataract patients. Retrospective study including 103 eyes from 103 elderly patients scheduled for cataract surgery that were measured on the same day
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Central serous chorioretinopathy: updates in the pathogenesis, diagnosis and therapeutic strategies Eye and Vis. (IF 4.2) Pub Date : 2023-07-11 Xinyuan Zhang, Connie Zhi Fong Lim, Jay Chhablani, Yew Meng Wong
Central serous chorioretinopathy (CSCR), first described by Albrecht von Graefe in 1866, is characterized by focal serous detachment of the neural retina and/or retinal pigment epithelium (RPE) in the posterior pole. CSCR is the first ever described pachychoroid disease. Most recently, hypothetical venous overload choroidopathy is also proposed due to its distinguished morphological and pathological
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Safety and efficacy of cataract surgery performed with a low-energy femtosecond laser compared with conventional phacoemulsification in Chinese patients: a randomized clinical trial Eye and Vis. (IF 4.2) Pub Date : 2023-07-02 Kai-Jing Zhou, Yusen Huang, Yong Wang, An-Peng Pan, Xu Shao, Rui-Xue Tu, A-Yong Yu
To compare the safety and efficacy of femtosecond laser-assisted cataract surgery (FLACS) performed with the low-energy FEMTO LDV Z8 (Ziemer Ophthalmic Systems AG, Port, Switzerland) laser compared with conventional phacoemulsification (CP) in Chinese patients. This prospective, multicenter, interventional study included 126 patients who were randomized (1:1) to undergo either FLACS or CP followed
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Incidence and characteristics of aqueous misdirection after glaucoma surgery in Chinese patients with primary angle-closure glaucoma Eye and Vis. (IF 4.2) Pub Date : 2023-07-01 Haishuang Lin, Jiaqian Li, Xuanli Zheng, Rui Wan, Mengtian Zhou, Yutong Ding, Yiting Ji, Yanqian Xie, Clement C. Tham, Shaodan Zhang, Yuanbo Liang
To report the incidence and clinical characteristics of aqueous misdirection (AM) after glaucoma surgery in Chinese patients with primary angle-closure glaucoma. Medical records of all patients diagnosed with primary angle-closure glaucoma who underwent glaucoma surgery in the Eye Hospital of Wenzhou Medical University between January 2012 and December 2021 were retrospectively reviewed. Cases of AM
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Optical changes and association with axial elongation in children wearing orthokeratology lenses of different back optic zone diameter Eye and Vis. (IF 4.2) Pub Date : 2023-07-01 Biyue Guo, Pauline Cho, Sin Wan Cheung, Randy Kojima, Stephen Vincent
To compare changes in ocular aberrations in children wearing orthokeratology (ortho-k) lenses with a back optic zone diameter (BOZD) of 6 mm (6-MM group) or 5 mm (5-MM group) and their associations with axial elongation (AE) over two years. Seventy Chinese children, aged 6 to < 11 years, with myopia between − 4.00 to − 0.75 D, were randomly allocated to 5-MM and 6-MM groups. Ocular aberrations were
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Refractive outcome and lens power calculation after intrascleral intraocular lens fixation: a comparison of three-piece and one-piece intrascleral fixation technique Eye and Vis. (IF 4.2) Pub Date : 2023-06-09 Markus Schranz, Adrian Reumüller, Klaudia Kostolna, Caroline Novotny, Daniel Schartmüller, Claudette Abela-Formanek
To evaluate the refractive prediction error of common intraocular lens (IOL) power calculation formulae in patients who underwent intrascleral IOL fixation using two different techniques. This is a prospective, randomized, longitudinal, single-site, single-surgeon study. Patients who underwent intrascleral IOL implantation using the Yamane or the Carlevale technique were followed up for a period of
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Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study Eye and Vis. (IF 4.2) Pub Date : 2023-06-06 Hao Wu, Tianli Peng, Weihe Zhou, Zihan Huang, Hongyu Li, Tengfei Wang, Jingwei Zhang, Kou Zhang, Haoer Li, Yunpeng Zhao, Jia Qu, Fan Lu, Xiangtian Zhou, Jun Jiang
Despite receiving orthokeratology (ortho-k), the efficacy of retarding ocular elongation during myopia varies among myopic children. The current study aimed to investigate the early changes of choroidal vasculature at one month after ortho-k treatment and its association with one-year ocular elongation, as well as the role of such choroidal responses in predicting the one-year control efficacy of ortho-k
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Repeatability of a fully automated swept-source optical coherence tomography biometer and agreement with a low coherence reflectometry biometer Eye and Vis. (IF 4.2) Pub Date : 2023-06-02 Alberto Domínguez-Vicent, Abinaya Priya Venkataraman, Amanda Dalin, Rune Brautaset, Robert Montés-Micó
To evaluate the repeatability of a fully automated swept-source optical coherence tomography (SS-OCT) and its agreement with an optical low coherence reflectometry (OLCR) for several biometric parameters. In this study, 74 eyes of 74 patients were measured using the Eyestar 900 SS-OCT and Lenstar LS 900 OLCR. Flat keratometry (K1) and steep keratometry (K2), central corneal thickness (CCT), anterior
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The Zhu-Lu formula: a machine learning-based intraocular lens power calculation formula for highly myopic eyes Eye and Vis. (IF 4.2) Pub Date : 2023-06-01 Dongling Guo, Wenwen He, Ling Wei, Yunxiao Song, Jiao Qi, Yunqian Yao, Xu Chen, Jinhai Huang, Yi Lu, Xiangjia Zhu
To develop a novel machine learning-based intraocular lens (IOL) power calculation formula for highly myopic eyes. A total of 1828 eyes (from 1828 highly myopic patients) undergoing cataract surgery in our hospital were used as the internal dataset, and 151 eyes from 151 highly myopic patients from two other hospitals were used as external test dataset. The Zhu-Lu formula was developed based on the
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Retinal image quality in myopic children undergoing orthokeratology alone or combined with 0.01% atropine Eye and Vis. (IF 4.2) Pub Date : 2023-06-01 Qi Tan, Pauline Cho, Alex L. K. Ng, George P. M. Cheng, Victor C. P. Woo, Stephen J. Vincent
The retinal image quality derived from lower-order (LOA) and higher-order aberrations (HOA) for fixed 3-mm and photopic pupil diameters, in children undergoing combined 0.01% atropine and orthokeratology (AOK) versus those receiving orthokeratology alone (OK) over two years was evaluated. The visual Strehl ratio based on the optical transfer function (VSOTF), derived from 2nd- to 4th-order terms (LOA
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Assessing abnormal corneal endothelial cells from in vivo confocal microscopy images using a fully automated deep learning system Eye and Vis. (IF 4.2) Pub Date : 2023-06-01 Jinghao Qu, Xiaoran Qin, Rongmei Peng, Gege Xiao, Shaofeng Gu, Haikun Wang, Jing Hong
The goal of this study is to develop a fully automated segmentation and morphometric parameter estimation system for assessing abnormal corneal endothelial cells (CECs) from LASER in vivo confocal microscopy (IVCM) images. First, we developed a fully automated deep learning system for assessing abnormal CECs using a previous development set composed of normal images and a newly constructed development
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Changes in the posterior corneal surface after femtosecond laser-assisted lenticule intrastromal keratoplasty (LIKE) performed into a pocket (SMI-LIKE) or under a flap (FS-LIKE) Eye and Vis. (IF 4.2) Pub Date : 2023-05-01 Shengtao Liu, Lanhui Yu, Yu Zhao, Xingtao Zhou
To compare the changes in posterior corneal surface after small-incision lenticule intrastromal keratoplasty (SMI-LIKE) and femtosecond laser-assisted lenticule intrastromal keratoplasty (FS-LIKE) for hyperopia correction. In this prospective comparative randomized study, 23 eyes with hyperopia were recruited. Eyes were categorized into two groups—SMI-LIKE group (11 eyes) and FS-LIKE group (12 eyes)
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Artificial intelligence-based refractive error prediction and EVO-implantable collamer lens power calculation for myopia correction Eye and Vis. (IF 4.2) Pub Date : 2023-05-01 Yinjie Jiang, Yang Shen, Xun Chen, Lingling Niu, Boliang Li, Mingrui Cheng, Yadi Lei, Yilin Xu, Chongyang Wang, Xingtao Zhou, Xiaoying Wang
Implantable collamer lens (ICL) has been widely accepted for its excellent visual outcomes for myopia correction. It is a new challenge in phakic IOL power calculation, especially for those with low and moderate myopia. This study aimed to establish a novel stacking machine learning (ML) model for predicting postoperative refraction errors and calculating EVO-ICL lens power. We enrolled 2767 eyes of
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Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies Eye and Vis. (IF 4.2) Pub Date : 2023-05-01 Kexin Li, Qianwen Gong, Bin Lu, Kaiyan Huang, Yixuan Tong, Tinashe Emmanuel Mutsvene, Meng Lin, Zhiqiang Xu, Fan Lu, Xingyi Li, Liang Hu
To investigate the anti-inflammatory and antioxidative effects of gallic acid (GA) on human corneal epithelial cells (HCECs) and RAW264.7 macrophages as well as its therapeutic effects in an experimental dry eye (EDE) mouse model. A cell counting kit-8 (CCK-8) assay was used to test the cytotoxicity of GA. The effect of GA on cell migration was evaluated using a scratch wound healing assay. The anti-inflammatory
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Visual and patient-reported outcomes of a diffractive trifocal intraocular lens in highly myopic eyes: a prospective multicenter study Eye and Vis. (IF 4.2) Pub Date : 2023-04-06 Jiaqi Meng, Yanwen Fang, Jingcai Lian, Xu Chen, Jing Zhou, Wenwen He, Keke Zhang, Fan Yang, Yi Lu, Xiangjia Zhu
To investigate the visual and patient-reported outcomes of a diffractive trifocal intraocular lens (IOL) in highly myopic eyes. Patients with planned cataract removal by phacoemulsification and implantation of a trifocal IOL (AT LISA tri 839MP) were enrolled in the prospective, multicenter cohort study. Patients were allocated into three groups according to their axial length (AL): control group, AL < 26 mm;
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Primary observations of EVO ICL implantation for high myopia with concave iris Eye and Vis. (IF 4.2) Pub Date : 2023-04-02 Zhe Zhang, Lingling Niu, Tingting Liu, Yang Shen, Jianmin Shang, Jing Zhao, Ruoyan Wei, Xingtao Zhou, Peijun Yao
To investigate the morphological changes of concave iris in myopic patients after EVO implantable collamer lens (ICL) implantation. EVO ICL candidates with posterior bowing iris were observed using ultrasound biometric microscopy (UBM) in this prospective nonrandomized observational study. Forty patients were enrolled, with 20 patients in the concave iris group and the other 20 patients in the control
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Simultaneous real-time analysis of tear film optical quality dynamics and functional visual acuity in dry eye disease Eye and Vis. (IF 4.2) Pub Date : 2023-04-02 An-Peng Pan, Yunjing Ma, Ruilin Hu, Xuejiao Cao, Yifen Wu, Kaijing Zhou, Ruixue Tu, Xu Shao, Shihao Chen, A-Yong Yu
To assess the effect of tear film instability in dry eye disease (DED) by measuring visual performance and tear film optical quality in a simultaneous real-time analysis system. Thirty-seven DED participants and 20 normal controls were recruited. A simultaneous real-time analysis system was developed by adding a functional visual acuity (FVA) channel to a double-pass system. Repeated measurements of
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Additive effects of narrowband light and optical defocus on chick eye growth and refraction Eye and Vis. (IF 4.2) Pub Date : 2023-04-01 Rachel Ka-man Chun, Kit-ying Choy, King-kit Li, Thomas Chuen Lam, Dennis Yan-yin Tse, Chi-ho To
In the past decade and during the COVID pandemic, the prevalence of myopia has reached epidemic proportions. To address this issue and reduce the prevalence of myopia and its complications, it is necessary to develop more effective interventions for controlling myopia. In this study, we investigated the combined effects of narrowband lights and competing defocus on eye growth and refraction in chicks
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Metabolomic analysis of aqueous humor reveals potential metabolite biomarkers for differential detection of macular edema Eye and Vis. (IF 4.2) Pub Date : 2023-04-01 Dan Jiang, Congcong Yan, Lina Ge, Chun Yang, Ying Huang, Yau Kei Chan, Chonghua Chen, Wei Chen, Meng Zhou, Bing Lin
Macular edema (ME) is a major complication of retinal disease with multiple mechanisms involved in its development. This study aimed to investigate the metabolite profile of aqueous humor (AH) in patients with ME of different etiologies and identify potential metabolite biomarkers for early diagnosis of ME. Samples of AH were collected from 60 patients with ME and 20 age- and sex-matched controls and
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Subconjunctival filtration in evolution: current evidence on MicroShunt implantation for treating patients with glaucoma Eye and Vis. (IF 4.2) Pub Date : 2023-03-02 Iqbal Ike K. Ahmed, Omar Sadruddin, Joseph F. Panarelli
Although traditional surgical procedures for glaucoma (such as trabeculectomy and tube-shunt implantation) can significantly reduce intraocular pressure (IOP), they are associated with numerous complications, some of which are vision-threatening, or involve prolonged recovery or a highly intensive postoperative course. Micro-invasive glaucoma surgery (MIGS) procedures have shown better safety but reduced
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Microglia activation and neuronal alterations in retinas from COVID-19 patients: correlation with clinical parameters Eye and Vis. (IF 4.2) Pub Date : 2023-03-01 Henar Albertos-Arranz, Natalia Martínez-Gil, Xavier Sánchez-Sáez, Agustina Noailles, Clara Monferrer Adsuara, Lidia Remolí Sargues, Juan J. Pérez-Santonja, Pedro Lax, Ramón Calvo Andrés, Nicolás Cuenca
Different ocular alterations have been described in patients with coronavirus disease 2019 (COVID-19). Our aim was to determine whether COVID-19 affected retinal cells and establish correlations with clinical parameters. Retinal sections and flat-mount retinas from human donors with COVID-19 (n = 16) and controls (n = 15) were immunostained. The location of angiotensin-converting enzyme 2 (ACE2) and
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Three-dimensional heads-up system assisted pars plana vitrectomy and subretinal recombinant tissue plasminogen activator injection for submacular hemorrhage Eye and Vis. (IF 4.2) Pub Date : 2023-03-01 Xinyu Zhao, Qing Zhao, Erqian Wang, Ningning Li, Lihui Meng, Wenfei Zhang, Tan Wang, Youxin Chen, Hanyi Min
To evaluate the outcomes of three-dimensional (3D) heads-up system assisted pars plana vitrectomy (PPV) and subretinal injection of recombinant tissue plasminogen activator (rt-PA) for submacular hemorrhage (SMH). Medical records of SMH patients who underwent 3D heads-up system assisted-PPV and subretinal injection of rt-PA from June 2021 to January 2022 were reviewed. The main outcomes included best-corrected
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Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism Eye and Vis. (IF 4.2) Pub Date : 2023-03-01 Mahmoud Abdel-Radi, Mahmoud Rateb, Mohamed G. A. Saleh, Mohamed Omar M. Aly
Conventional mechanical or alcohol-assisted photorefractive keratectomy (PRK) techniques for correction of hyperopia and hyperopic astigmatism were associated with inconsistent results. The aim of this study is to evaluate the 12-month visual and refractive outcomes of the relatively new single-step transepithelial photorefractive keratectomy (TE-PRK) for moderate hyperopia and hyperopic astigmatism
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Agreement between a new optical low coherence reflectometry biometer and an anterior segment optical coherence tomographer Eye and Vis. (IF 4.2) Pub Date : 2023-02-25 Yiran Wang, Ting Wan, Luze Liu, Yuyuan Xue, Xinyao Chen, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinjin Yu, Jinhai Huang
To assess agreement of measurements between a new optical low coherence reflectometry (OLCR) biometer (SW-9000, Suoer, Tianjin, China) and a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence, Italy) in healthy subjects. A total of 66 right eyes from 66 healthy subjects were enrolled in this prospective study. Three consecutive measurements were randomly
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Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy Eye and Vis. (IF 4.2) Pub Date : 2023-02-04 Yunhai Tu, Haochen Jin, Mingna Xu, Weijie Liu, Xiaozhou Hu, Mengting Wang, Jie Ye, Zihui Liu, Mengyuan Gao, Fang Hou, Zhong-Lin Lu, Wencan Wu
To assess the accuracy of contrast sensitivity function (CSF) in detecting dysthyroid optic neuropathy (DON) at an early stage in thyroid-associated ophthalmopathy (TAO) patients and to examine potential factors that may be linked to early visual impairments in these individuals. A total of 81 TAO patients (50 non-DON and 31 DON), and 24 control subjects participated in the study. CSF was measured
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The cause of redetachment after vitrectomy with air tamponade for a cohort of 1715 patients with retinal detachment: an analysis of retinal breaks reopening Eye and Vis. (IF 4.2) Pub Date : 2023-02-03 Chuandi Zhou, Chufeng Gu, Bo Li, Yujie Wang, Yanan Hu, Xinping She, Ya Shi, Mingming Ma, Tao Sun, Qinghua Qiu, Ying Fan, Fenge Chen, Hong Wang, Kun Liu, Xiaodong Sun, Xun Xu, Zhi Zheng
To investigate the prevalence and predictors of retinal breaks reopening after vitrectomy with air tamponade in rhegmatogenous retinal detachment (RRD). A retrospective cohort study was conducted in Shanghai General Hospital. Chart review was performed among 1715 patients with primary RRD who received pars plana vitrectomy (PPV) with air tamponade as initial management. Patients were followed up for
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Long-term follow-up of changes in ocular biometric parameters in orthokeratology lens wearers with relatively large-scale axial length reduction Eye and Vis. (IF 4.2) Pub Date : 2023-02-02 Tao Tang, Xuewei Li, Sitong Chen, Qiong Xu, Heng Zhao, Kai Wang, Yan Li, Mingwei Zhao
To investigate ocular biological characteristics for myopic children with axial length (AL) reduction during orthokeratology (Ortho-K) treatment and provide clinical clues for better myopia control effects. Changes in ocular parameters and treatment zone (TZ) in 75 subjects who completed one-year Ortho-K treatment were retrospectively reviewed. The subjects were divided into two groups according to
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Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens Eye and Vis. (IF 4.2) Pub Date : 2023-02-01 Tingyi Wu, Yuexin Wang, Jiazhi Yu, Xiaotong Ren, Yuanting Li, Weiqiang Qiu, Xuemin Li
The aim of the study was to compare the dynamic defocus curve on patients post-implantation of the extended depth-of-focus (EDOF) and monofocal intraocular lens (IOL). A total of 62 age-related cataract patients receiving phacoemulsification with implantation of TECNIS Symfony (ZXR00) or monofocal IOLs were enrolled. The binocular static and dynamic defocus curves with corrected distance visual acuity
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Reproducibility of each retinal layer thickness measurement in epiretinal membrane patients with ectopic inner foveal layers Eye and Vis. (IF 4.2) Pub Date : 2023-01-04 Jung, Il, Na, Yong-Jin, Lee, Sung-Chul, Lee, Min-Woo
To identify the reliability of each retinal layer thickness measurement in epiretinal membrane (ERM) patients with ectopic inner foveal layers (EIFLs). Subjects were divided into two groups: ERM patients with EIFLs (Group 1) and without EIFLs (Group 2). The retinal layer thickness was measured twice, and intraclass correlation coefficient (ICC) and coefficient of variation (CV) values were calculated
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Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture Eye and Vis. (IF 4.2) Pub Date : 2023-01-04 Xia, Mingfang, Zhang, Endong, Yao, Fei, Xia, Zhaohua, Zhou, Mingmin, Ran, Xufang, Xia, Xiaobo
To describe the regional differences of the sclera in ocular hypertension (OHT) models with the inappropriate extension of the ocular axis. To discover the regional differences of the sclera at the early stage, OHT models were established using circumlimbal suture (CS) or sclerosant injection (SI). Axial length (AL) was measured by ultrasound and magnetic resonance imaging. The glaucoma-associated
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A three-dimensional morpho-volumetric similarity study of Down syndrome keratopathy vs. keratoconus Eye and Vis. (IF 4.2) Pub Date : 2023-01-03 Toprak, Ibrahim, Cavas, Francisco, Velázquez, José S., del Barrio, Jorge L. Alio, Alio, Jorge L.
To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling. Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness