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Understanding the impact of risankizumab on keratinocyte-derived IL-23A in a novel organotypic 3D skin model containing IL-23A responsive and IL-17A producing γδ-T-cells Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-29 Laura Huth, Philipp M Amann, Yvonne Marquardt, Manuela Jansen, Jens Malte Baron, Sebastian Huth
PurposeTo study the effects of the anti-IL-23A antibody risankizumab on the IL-36γ/IL-23A/IL-17A signaling cascade we used a newly developed 3D skin model consisting of primary human keratinocytes,...
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Clinical features and biomarker differences of severe intrinsic and extrinsic atopic dermatitis Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-23 Zhong Liu, Zeqi Shi, Yunhua Deng
Atopic dermatitis (AD) can be classified into intrinsic AD(IAD) and extrinsic AD(EAD). However, the differences in clinical features and pathogenesis between these two subtypes of AD are currently ...
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Evaluation of corneal endothelial cell morphology off and on treatment by specular microscopy in children and adolescents with attention deficit hyperactivity disorder Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-18 Hakan Koc, Bedia Sultan Önal, Esra Hoşoğlu
To determine the structure and properties of corneal endothelial cells in children and adolescents with ADHD who received methylphenidate treatment at least six months.The prospective, observationa...
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The efficacy of HDDPiW-jSB solution on docetaxel-induced alopecia of rats Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-05 Bilgin Demir, Buket Demirci, Canten Tataroglu, Sabri Barutca, Duygu Barutca
Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn’t have an effective pharmacological treatment yet. In this study we aimed to researc...
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Biochemical and Histopathological Evaluation of Systemic and Ocular Toxicity of Favipiravir in Rats Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-04 Delil Özcan, Fatih Özçelik, Renad Mammadov, Mehmet Aktaş, Fikret Altındağ, Abdurrahman Alpaslan Alkan, Murat Karapapak, Durdu Altuner, Halis Süleyman
Purpose: Favipiravir used against COVID-19 is an antiviral drug that causes adverse reactions such as hyperuricemia, liver damage and hematopoetic toxicity. The aim of the study was to investigate ...
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Potential inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, hyperproliferation, and hyperplasiogenic responses by celecoxib in mouse skin Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2024-01-01 Shakilur Rahman, Rizwanul Haque, Sheikh Raisuddin
Skin exposure to noxious agents leads to cutaneous lesion marked by an increase in inflammation, cellular proliferation, and hyperplasiogenic reactions. Studies have demonstrated that these damages...
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Ocular irritation reversibility assessment of a laundry detergent using the Porcine Corneal Opacity Reversibility Assay (PorCORA): a focused study Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-12-15 Puneet Vij, Ashley Brinkman, Rachael M. Koch, George DeGeorge, Matthew Wolter
Consumer product manufacturers utilise a spectrum of alternative ocular irritation assays, as these tests do not require the use of live animals. Despite their usefulness, no regulatory-accepted as...
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Time to treat the climate and nature crisis as one indivisible global health emergency Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-11-06 Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E. Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
Published in Cutaneous and Ocular Toxicology (Vol. 43, No. 1, 2024)
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A systematic review of heavy metals contamination in cosmetics Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-11-02 Opoku Gyamfi, James Aboko, Edward Ankapong, Jemima Tiwaa Marfo, Nana Yaa Awuah-Boateng, Kofi Sarpong, Emmanuel Dartey
Background: Globally, the consumption and use of cosmetics have increased exponentially. The presence of hazardous metals raises worries about their potential long-term impacts on human health. Obj...
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Does corneal tattooing affect the conjunctival microbiota? Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-11-02 Omer Faruk Yilmaz, Abdurrahman Sarmıs, Muhammet Ali Mutlu, Halit Oguz
This study aimed to investigate the effects of commercial tattoo inks used in corneal tattooing on conjunctival microbiota.This prospective case control study consisted of 125 participants divided ...
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Literature analysis of cutaneous adverse reactions induced by tislelizumab Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-11-01 Qingli Guo, Lili Jin, Tingting Zhang, Ruihao Gao, Kaili Zou, Min Fu, Hengtai Bi, Junyao Zhang, Min Zhang
Tislelizumab may induce immune-related adverse events, especially adverse skin events. Early detection and timely intervention of cutaneous adverse events are crucial to improve patients’ quality o...
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Toxicity of superparamagnetic iron oxide nanoparticles on retinoblastoma mitochondria Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-31 Enayatollah Seydi, Ghazaleh Tahmasebi, Abdollah Arjmand, Jalal Pourahmad
Retinoblastoma (RB) is one of the most important cancers in children with a higher rate of prevalence in developing countries. Despite different approaches to the treatment of RB, it seems necessar...
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Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcularTM reconstructed human corneal epithelium and bovine corneal opacity and permeability assays Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-31 Anna J. van der Zalm, Amber B. Daniel, Hans A. Raabe, Neepa Choksi, Tara Flint Silva, Julie Breeden-Alemi, Lindsay O’Dell, Nicole C. Kleinstreuer, Anna B. Lowit, David G. Allen, Amy J. Clippinger
Many sectors have seen complete replacement of the in vivo rabbit eye test with reproducible and relevant in vitro and ex vivo methods to assess the eye corrosion/irritation potential of chemicals....
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Outcomes and success of amniotic membrane transplantation for the treatment of corneal diseases# Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-31 Ozlem Dikmetas, Yasemin Kapucu, Ali Bülent Cankaya, Sibel Kocabeyoglu
The amniotic membrane (AM), the inner layer of the placenta, is a semitransparent, avascular, and thin tissue that is useful due to its structure. Amniotic membrane transplantation (AMT) avoids the...
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Allergic contact dermatitis to lip care cosmetic products – a systematic review Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-30 Biplab Pal, Sweta Kumari, Alka Kumari, Sachin Kumar Singh, Harish Babbar
Aim: Lip care cosmetics products are any external preparation used by people to prevent drying, chapping, dullness, and beautification of lips. This study aimed to review the literature on allergic...
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The effect of IL17 and IL23 inhibitors on hematological parameters and C-reactive protein in psoriasis patients Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-28 Mustafa Esen
In the quest for objective biomarkers for psoriasis, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), and mean platelet volume (MPV) have been used ...
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Retinal nerve fiber layer and ganglion cell complex thickness in diabetic smokers without diabetic retinopathy Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-24 Kübra Özata Gündoğdu, Emine Doğan, Erkan Çelik, Gürsoy Alagöz
To compare the thickness of the retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL) in smoker and nonsmoker diabetics without diabetic retinopathy.Patients wit...
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Effect of isotretinoin treatment on inflammatory and hematological parameters in patients with acne vulgaris Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-10-14 Mustafa Esen
Although the inflammatory and anti-inflammatory effects of isotretinoin (ISO) treatment in patients with acne vulgaris have been discussed in the literature in recent years, no sensitive and specif...
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Comparison of three different dosages of low-level laser therapy on expression of cell proliferation and inflammatory markers following ovariohysterectomy in rats Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-09-14 Bülent Polat, Damla Tuğçe Okur, Armağan Çolak, Sıtkıcan Okur, Mustafa Özkaraca, Kader Yilmaz
The objective of the current study was to evaluate Low-level laser therapy (LLLT) on the healing of incisional wounds following ovariohysterectomy in rats, by means of subjective histopathological ...
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Cellular toxicity profile of a new ophthalmic sponge Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-09-07 Keon Woo Park, Ji Woong Chun, Seong Won Yang, Seon Joo Park, Da Eun Jeong, Jae Woong Koh
Introduction: Ophthalmic sponges are used for cleaning the eye surface and absorbing fluids during ophthalmic procedures. This study compared the biological safety and stability of a new ophthalmic...
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Evaluation of peripapillary choroidal vascularity index in young smokers Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-09-05 Mehmet Tahir Eski, Taha Sezer, Havvanur Bayraktar, Emir Altıkardeşler
Purpose: This retrospective study aimed to compare the peripapillary choroidal vascularity index (CVI) between young smokers who smoked less than 5 packs/year and non-smokers.Methods: The study inc...
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Development of a simplified human embryonic stem cell-based retinal pre-organoid model for toxicity evaluations of common pollutants Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-08-27 Yue Wang, Nuoya Yin, Renjun Yang, Miaomiao Zhao, Shichang Li, Shuxian Zhang, Yanyi Zhao, Francesco Faiola
To explore the retinal toxicity of pharmaceuticals and personal care products (PPCPs), flame retardants, bisphenols, phthalates, and polycyclic aromatic hydrocarbons (PAHs) on human retinal progeni...
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The influence of smoking on retinal ganglion cell-inner plexiform layer complex in male diabetes Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-08-10 Lu Li, Xudong Peng, Nan Jiang, Meng Yan, Zhaoxia Zheng, Duo Zhang, Lina Zhang
This study aims to evaluate the influence of smoking on ganglion cell-inner plexiform layer complex (GC-IPL) thickness and central macular thickness (CMT) measured by spectral domain optical cohere...
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The effect of hyperbaric oxygen therapy on corneal endothelial structure and anterior segment parameters Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-08-09 Murat Garlı, Tuncay Küsbeci, Figen Aydın, Okan Akmaz
To assess the effect of hyperbaric oxygen therapy (HBOT) on corneal endothelial structure and anterior segment parameters in healthy eyes.17 eyes of 17 patients who were scheduled to receive HBOT f...
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The effect of baseline intraocular pressure and anterior segment parameters on intraocular pressure after intravitreal bevacizumab injection Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-08-07 Zeynep Özer Özcan, Gizem Gürbostan Soysal, Nesime Setge Tıskaoğlu, Mustafa Berhuni
We aimed to compare the predictive effect of pre-injection intraocular pressure (IOP) and anterior segment parameters on post-injection IOP values after intravitreal bevacizumab injection for neova...
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Endothelial loss following postoperative intracameral triamcinolone acetonide and subconjunctival dexamethasone injections Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-08-01 Fatma Sali, Veysel Aykut, Ahmad Kunbaz, Ebubekir Durmus, Mustafa Hepokur, Halit Oguz, Fehim Esen
To compare endothelial toxicity and efficacy of two local steroid injections (intracameral triamcinolone acetonide and subconjunctival dexamethasone) in controlling postoperative inflammation follo...
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Mucocutaneous alterations and complications in amphetamine abusers: a narrative review Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-28 Mahdi Balali-Mood, Rodney D. Sinclair, Emadodin Darchini-Maragheh, Leila Etemad
Amphetamines are the second most commonly used illicit drug worldwide. Amphetamine use can result in significant cutaneous morbidity. This review highlights the dermatological manifestations of amp...
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Aging of the skin in pseudoexfoliation syndrome Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-26 Hakan Cinal, Halil İbrahim Yener
It was reported that pseudoexfoliative material deteriorates iris, brain, heart and lung functions. This material is also found in the skin.The purpose of this study was to investigate the possible...
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Systemic isotretinoin therapy and central macular and choroidal thicknesses in acne vulgaris: is there any association? Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-26 Alireza Dehghani, Saeed Kargar, Gita Faghihi, Neda Adibi, Pegah Noorshargh, Shakiba Dehghani, Mohsen Pourazizi, Bahareh Abtahi-Naeini
Abstract Purpose To investigate the effect of oral isotretinoin therapy on central macular thickness (CMT) thickness and choroidal thickness (CT) using optical coherence tomography (OCT). Methods CT and CMT thickness of 43 eyes were evaluated at baseline, the third, and sixth month of isotretinoin therapy by spectral-domain OCT. For assessment of CT, OCT measurements were obtained at the fovea with
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Evaluation of choroidal thickness and choroidal vascular index in patients using combined oral contraceptive pills Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-18 Mehmet Icoz, Sema Yuzbasıoglu
To evaluate the choroidal thickness and choroidal vascular index (CVI) in healthy women using the combined oral contraceptive pill (COCp).This prospective study included 30 women using COCp (3 mg d...
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Topical application of sh-oligopeptide-1 and clinical trials with cosmetic preparations: risk or fraud? Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-14 Pedro A. Martínez-Carpio
sh-oligopeptide-1 is a cosmetic that is considered to be the bioequivalent of the Epidermal Growth Factor (EGF).The systematic search and selection of the information available on sh-oligopeptide-1...
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Effect of smoking on corneal and lens clarity: a densitometric analysis Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-13 Delil Özcan
To assess the effect of chronic cigarette smoking on corneal and lens densitometry measurements using Pentacam HR and to compare the results obtained with those in non-smokers.This cross-sectional ...
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Early effects of intravitreal anti-VEGF agents on cornea and visual acuity in patients with diabetic retinopathy Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-13 Xuanli Liu, Wei Shen, Wei Xia, Peirong Lu
This study aimed to investigate the early effects of intravitreal anti–vascular endothelial growth factor (anti-VEGF) agents on the cornea and visual acuity in patients with diabetic retinopathy (D...
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Effectiveness and safety of a cream product containing zinc oxide for alleviating mosquito bite symptoms Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-12 Vu Nguyet Minh, Vu Hai Yen, Dinh Thi Hoa, Nguyen Thi Huong, Bui Quang Hao
BACKGROUND: People frequently experience discomfort with immediate wheal, delayed papules, and pruritus from mosquito bites. A topical cream product containing zinc oxide is commercially available ...
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Compare of optic coherence tomography parameters in recreational synthetic tetrahydrocannabinol use and healthy control Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-12 Mehmet Tahir Eski, Kuddusi Teberik, Sezer Taha, Bora Büken, Feruza Turan Sönmez
Abstract Purpose To evaluate retinal thickness (RT), retinal nerve fiber layer thickness (RNFLT), and choroidal thickness (CT) changes in synthetic cannabinoid (SC) users. Methods This prospective study evaluated the RT, RNFLT, and CT values of 56 SC users and 58 healthy controls. The individuals using SCs were referred to us by our hospital’s forensic medicine department. Retinal and choroidal images
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Investigating the effects of dermal exposure to in-vivo animal models on the riot-control properties of a powder formulation of Tragia involucrata leaf hair lining Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-10 Trishna Mani Nath, Sanghita Das, Zothanpuia, Pronobesh Chattopadhyay
Abstract Purpose: Riot control agents (RCAs) such as CS, CN, CR, PAVA, and OC, etc., are already in use and has produced numerous health risks, including skin burns, dermatitis, gastrointestinal issues, impairment of respiratory variables, conjunctivitis, etc., and even prolonged and repeated exposure may cause death. Therefore, there is a demand and need for non-lethal, non-toxic RCAs that can effectively
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Oral isotretinoin in the treatment of juvenile acne and psychiatric adverse effects – a systematic review Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-07-05 Tânia Fernandes, Sofia Magina
Abstract Purpose Acne vulgaris is a very prevalent dermatological condition, especially among adolescents and young adults up to 25 years old, classifying it as juvenile acne. One of the most effective treatments for severe acne is isotretinoin, a derivative of retinoic acid. Despite its high efficacy, this drug has been linked to several side effects including psychiatric adverse alterations, such
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Endothelial dysfunction of the cornea after exposure to sprayed venom from hornets Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-30 Takashi Ono, Shigefumi Takahashi, Takahiro Hisai, Michiyo Kato, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Kazunori Miyata
Ocular injuries due to Hymenoptera venom are uncommon and most injuries occur on the ocular surface. We reported two rare cases of corneal endothelial damage caused by hornet venom that was sprayed...
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Cytological and functional effect of complement 3a on Human Scleral Fibroblasts Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-28 Kang Xiao, Ying Jie, Mingyue Luo, Qin Long
Abstract Purpose The complement system is considered to play an important role in the progression of myopia, whereas the influence of complement activation on the human scleral fibroblasts (HSFs) remains unknown. Hence, the effect of complement 3a (C3a) on HSFs was investigated in this study. Methods HSFs were cultured with exogenous C3a at 0.1 μM for various periods following different measurement
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Short time effect of sodium fluorescein on chorodial vascularity index Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-27 Selim Cevher, Mehmet Barış Üçer, Mustafa Duran
Abstract Purpose This study aimed to investigate the effect of sodium fluorescein on the choroidal vascularity index (CVI). Materials and Methods In this cross-sectional study, a total of 27 eyes of 27 mild nonproliferative diabetic retinopathy patients (without maculopathy and any systemic disease) who performed fluorescein angiography (FA) procedure were included. Choroidal parameters such as choroidal
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Effect of adenosine triphosphate on amiodarone-induced optic neuropathy in rats: biochemical and histopathological evaluation Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-27 Kemal Bayrakçeken, Rukiye Kilic Ucgul, Taha Coban, Gulce Yazıcı, Halis Suleyman
Abstract Objective This study aims to investigate possible preventive effect of ATP on optic nerve damage caused by amiodarone in rats. Material and method Thirty albino male Wistar rats weighing between 265 and 278 g were used in the study. Before the experiment, the rats were housed at 22 °C in a 12-h light/dark cycle under appropriate condition. The rats were equally divided into five groups of
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Toxicological evaluation of a nonlethal riot control combinational formulation upon dermal application using animal models Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-25 Sanghita Das, Achintya Saha, Amartya Banerjee, Danswrang Goyary, Sanjeev Karmakar, Sanjai Kumar Dwivedi, Pronobesh Chattopadhyay
Abstract Numerous adverse effects on human health have been reported in epidemiological studies of oleoresin capsicum (OC) and other riot control agents (RCAs). Importantly, the daunting risk of such RCAs can be neutralized by optimizing the desired concentration of such agents for mob dispersal. Hence, a nonlethal riot control combinational formulation (NCF) was prepared for dispersing rioters without
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Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-23 Ji Young Moon, Wool Suh, Roo Min Jun, Kyung Eun Han
Abstract Purpose To investigate the toxicity of repeated simultaneous intrastromal and intracameral injections of voriconazole in corneal endothelial cells in a rabbit model. Methods Thirty-six eyes of 18 New Zealand white rabbits (six eyes per group) were divided into 6 groups according to the concentration of voriconazole (Group A, 0%; Group B, 0.05%; Group C, 0.1%; Group D, 0.25%; Group E, 0.5%;
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Determination of heavy metals and risk assessment in nail cosmetics sold in Seoul, Korea Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-22 Suun Kim, Chaeman Choi, Myeongsook Lee, Insook Hwang
Abstract Objective The objective of this study was to evaluate some toxic levels of nail cosmetics marketed in Seoul, Korea and health risk assessment on humans. Methods We collected 45 random nail cosmetics and analysed for lead, cadmium, arsenic and antimony by inductively coupled plasma-optical emission spectrometry (ICP-OES). Results Four metals concentrations were Pb 0.037 ± 0.083 (
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Tamoxifen related chorioretinal structural changes Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-15 İnci Elif Erbahçeci Timur, Vehbi Açıkgöz, Nagihan Uğurlu, Bülent Yalçın, Mehmet Ali Nahit Şendur, Mutlu Hızal, Halil Kara
Abstract Purpose To evaluate the vascular structure of the choroid and each retinal layer in patients with breast cancer on tamoxifen therapy and compare them with healthy subjects. Materials and Methods 124 eyes of 62 patients with breast cancer who were on tamoxifen therapy (group 1) and 80 eyes of 40 healthy controls (group 2) were included in this prospective cohort study. The structure of the
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Methyl(chloro)isothiazolinone contact allergy: a monocentric experience from Turkey Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-01 Didem Kazan, Evren Odyakmaz-Demirsoy, Rebiay Kiran, Aysun Şikar-Aktürk, Nilgün Sayman, Dilek Bayramgürler
Abstract Introduction Due to their ubiquitous use, isothiazolinones caused allergic contact dermatitis epidemics and their use was restricted by legal regulations. Objectives We aimed to evaluate demographic data, clinical findings, and patch test features of patients with methylisothiazolinone (MI) and/or methylchloroisothiazolinone(MCI) sensitivity in our study. Methods This study is a bidirectional
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Electrophysiological effects of hyperbaric oxygen treatment on the healthy retina Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-06-01 Nur Demir, Belma Kayhan, Selin Gamze Sumen, Murat Sonmez, Nejla Tukenmez Dikmen
Abstract Purpose The study aimed to investigate the electrophysiological effects of hyperbaric oxygen treatment (HBOT) on the retina after ten sessions in healthy eyes. Methods This prospective, interventional study evaluated forty eyes of twenty patients who were treated with HBOT of ten sessions with the diagnosis of an extraocular health problem. All patients underwent a complete ophthalmologic
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Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-05-24 Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay
Abstract Purpose To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME). Methods In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial
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Evaluation of uveitis events in real-world patients receiving immune checkpoint inhibitors based on the FAERS database Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-05-11 Qianqian Fan, Huan Chen, Yang Hu, Bin Zhao
Abstract Purpose Immune checkpoint inhibitors (ICIs) have emerged as a novel class of drugs carrying a potential risk of uveitis. Due to the rarity, current knowledge on this safety issue is still incomplete. This study employed the post-marketing surveillance data to comprehensively describe and assess the uveitis events after the use of ICIs. Methods Data between 2004 and 2021 were downloaded from
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1,25-Dihydroxvitamin D3 attenuates the damage of human immortalised keratinocytes caused by Ultraviolet-B Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-05-08 Pingwei Wang, Dongge Liu, Jiajing Cui, Shuqi Yan, Yujun Liang, Qianqian Chen, Yanping Liu, Shuping Ren, Peng Chen
Abstract Objective Ultraviolet-B (UVB) radiation is an important factor in causing skin damage. The study is to explore whether 1,25-Dihydroxvitamin D3(1,25(OH)2D3) will attenuate the damage of human immortalised keratinocytes (HaCaT) cells caused by UVB and relevant underlying mechanisms. Methods CCK-8 was employed to determine the UVB irradiation intensity and 1,25(OH)2D3 concentration. Western blot
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The effects of cream-based Triticum vulgare with and without therapeutic ultrasound on excisional wound healing in diabetic rats Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-04-20 Ayşe Gölgeli Bedir, Latif Emrah Yanmaz
Abstract Purpose The purpose of the current study was to evaluate the effect of Triticum vulgare (TVE) alone or combined with therapeutic ultrasound (TUS) on wound healing in a diabetic rat model. Materials and Methods A total of 72 male Wistar rats were randomly divided into four groups: Group Control, wounded rats without treatment; Group TUS, wounded rats with TUS application; Group TVE, wounded
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Effectiveness of ketorolac-soaked bandage contact lens for pain management after photorefractive keratectomy Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-04-20 Fikret Ucar, Ekrem Kadioglu
Abstract Objective To evaluate the effect of ketorolac-soaked contact lenses (CLs) on postoperative pain after photorefractive keratectomy (PRK) and their potential side effects including conjunctival hyperaemia and delayed epithelial healing. Methods This is a prospective, randomised, double-blind, contralateral eye study. A total of 310 eyes of 155 patients who underwent PRK in both eyes were included
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Vanadium inhalation effects on the corneal ciliary neurotrophic factor (CNTF): study in a murine model Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-02-14 Isis Mendoza-Aldaba, Nelly López-Valdez, María Eugenia Cervantes-Valencia, Teresa Imelda Fortoul
Abstract Purpose Air pollution is a public health problem caused by predatory human activities and the indiscriminate burning of fossil fuels that liberate particulate matter (PM) into the atmosphere. Vanadium (V) adheres to them and reaches the bloodstream and different organs such as the eye when inhaled. Another way to reach the eye is by direct contact, and the cornea is the first layer exposed
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Further optimisation of a macromolecular ocular irritation test (OptiSafeTM) Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-01-28 Stewart Lebrun, Sara Chavez, Linda Nguyen, Roxanne Chan
Abstract Purpose OptiSafeTM (OS) is a shelf stable, nonanimal test for ocular irritation. A recent database search found that half of the OS false positive (FP) materials were associated with reactive oxygen chemistries but were not eye irritants in vivo (based on historical rabbit studies by other groups). We hypothesized that naturally occurring tear antioxidants protect the eye from reactive chemistries
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Effects of lipid-containing eye drops on the ocular surface and in vivo confocal microscopy findings in patients using systemic isotretinoin Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-01-22 Ahmet Alp Bilgic, Huri Sabur, Mutlu Acar, Filiz Canpolat
Abstract Objective To evaluate the effects of lipid-containing Rohto Dry Aid eye drops and sodium hyaluronate eye drops on the ocular surface and in vivo confocal microscopy (IVCM) findings in patients using systemic isotretinoin. Methods This retrospective study included 71 patients using systemic isotretinoin for acne vulgaris. Ocular surface and tear functions were evaluated with the tear break-up
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Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2023-01-19 Nergis Akbaş, Emin Murat Akbaş, Zeynep Süleyman, Betül Çiçek, Ahmet Gökhan Ağgül, Behzad Mokhtare, Halis Süleyman
Abstract Purpose Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage. Materials
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Toxicity of Persian Gulf shell-less marine mollusc (Peronia peronii) methanolic extract on melanoma tumor mitochondria Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2022-12-12 Yalda Arast, Aida Jabbarzadeh, Farahnaz Tanbakosazan, Abdollah Arjmand, Amir. Vazirizadeh, Jalal Pourahmad
Abstract Introduction Melanoma is known as an aggressive and highly lethal cancer. The poor prognosis and resistance to treatment are characteristics of melanoma. In melanoma cells, apoptosis signaling which relies heavily on the acute activity of mitochondria and reactive oxygen species (ROS) formation is suppressed. Studies have shown that compounds isolated from marine herbs and animals, have been
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Effects of second-generation H1-antihistamine drugs on angiogenesis in in vivo chick chorioallantoic membrane model Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2022-12-05 Nilay Duman, Reşat Duman, Ayhan Vurmaz
Abstract Background Literature on the effects of second-generation H1-antihistamines on angiogenesis is limited. Objectives To investigate the effects of cetirizine, desloratadine, and rupatadine (second-generation H1-antihistamines commonly used in dermatology clinics) on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model. Methods The study was approved by the local ethics committee
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Analysis of corneal topographic and densitometric properties in patients receiving systemic isotretinoin therapy Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2022-12-04 Mustafa Tosun, Erman Bozali, Duygu Yalınbaş Yeter, Anıl Selim Apa
Abstract Purpose To evaluate dry eye parameters, corneal topographic features, corneal densitometric changes, and anterior segment parameters in patients receiving systemic isotretinoin treatment. Methods This prospective cross-sectional study included 66 eyes of 33 patients who were started on oral isotretinoin therapy for severe acne vulgaris. All patients were evaluated in terms of ocular surface
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Smoking and environmental tobacco smoke exposure: implications in ocular disorders Cutan. Ocul. Toxicol. (IF 1.6) Pub Date : 2022-11-17 Saeed Karimi, Hosein Nouri, Sahar Mahmoudinejad-Azar, Seyed-Hossein Abtahi
Abstract Purpose This article aims to gather and review the available knowledge on several implications of smoking and environmental tobacco smoke (ETS) exposure in ocular disorders and provides pathomechanistic insights where applicable. Materials and Methods PubMed and Scopus databases were searched for relevant studies on the association of smoking and ETS exposure with various ocular disorders