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Erratum in: Perceptual Learning Based on the Lateral Masking Paradigm in Anisometropic Amblyopia With or Without a Patching History Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01
Abstract not available
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Inequalities in Uptake and Use of Digital Applications for Home-Monitoring of Neovascular Age-Related Macular Degeneration in an Elderly Visually Impaired Population: The MONARCH Study Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Ruth E. Hogg, Robin Wickens, Sean O'Connor, Eleanor Gidman, Elizabeth Ward, Tunde Peto, Benjamen J. L. Burton, Paul Knox, Andrew J. Lotery, Sobha Sivaprasad, Michael Donnelly, Chris A. Rogers, Barnaby C. Reeves
Purpose: To describe inequalities in the Monitoring for Neovascular Age-related Macular Degeneration Reactivation at Home (MONARCH) diagnostic test accuracy study for: recruitment; participants’ ability to self-test; and adherence to testing using digital applications during follow-up. Methods: Home-monitoring vision tests included two tests implemented as software applications (apps: MyVisionTrack
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Peripapillary Atrophy Area as an Indicator of Glaucomatous Structural and Functional Progression Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Maroun Khreish, Joel S. Schuman, TingFang Lee, Zeinab Ghassabi, Ronald Zambrano, Jiyuan Hu, Hiroshi Ishikawa, Gadi Wollstein, Fabio Lavinsky
Purpose: To determine whether peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional damage and progression. Methods: In this retrospective longitudinal analysis from ongoing prospective study we qualified 71 eyes (50 subjects) with glaucoma. All subjects had a comprehensive ophthalmic examination, visual field (VF), and spectral-domain optical coherence tomography
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Social Risk Groups in Patients With Diabetes With Differing Eye Care Utilization and Vision Outcomes Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Cindy X. Cai, Dingfen Han, Diep Tran, Jose Amezcua Moreno, Scott L. Zeger, Deidra C. Crews
Purpose: To evaluate whether latent class analysis on social determinants of health (SDoH) data can identify social risk groups that differ by adverse SDoH and vision outcomes in patients with diabetes. Methods: This was a prospective cohort study of adults ≥18 years with diabetes who completed a SDoH survey. Latent class analysis was used to cluster patients into social risk groups. The association
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Assessing Diabetic Retinopathy Staging With AI: A Comparative Analysis Between Pseudocolor and LED Imaging Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Maria Vittoria Cicinelli, Salvatore Gravina, Carola Rutigliani, Lisa Checchin, Lamberto La Franca, Rosangela Lattanzio, Francesco Bandello
Purpose: To compare the diagnostic performance of artificial intelligence (AI)-based diabetic retinopathy (DR) staging system across pseudocolor, simulated white light (SWL), and light-emitting diode (LED) camera imaging modalities. Methods: A cross-sectional investigation involved patients with diabetes undergoing imaging with an iCare DRSplus confocal LED camera and an Optos confocal, ultra-widefield
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RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Ailin Song, Jay B. Lusk, Kyung-Min Roh, S. Tammy Hsu, Nita G. Valikodath, Eleonora M. Lad, Kelly W. Muir, Matthew M. Engelhard, Alexander T. Limkakeng, Joseph A. Izatt, Ryan P. McNabb, Anthony N. Kuo
Purpose: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with a deep learning model in detecting referable posterior segment pathology in OCT images of emergency department patients. Methods: A deep learning model, RobOCTNet, was trained and internally tested to classify OCT images as referable versus non-referable for ophthalmology
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Validation of a Wearable Virtual Reality Perimeter for Glaucoma Staging, The NOVA Trial: Novel Virtual Reality Field Assessment Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Chris Bradley, Iqbal Ike K. Ahmed, Thomas W. Samuelson, Michael Chaglasian, Howard Barnebey, Nathan Radcliffe, Jason Bacharach
Purpose: Compare estimated sensitivities of SITA-Standard to the RATA-Standard algorithm of the Radius virtual reality perimeter (VRP), and measure concordance in glaucoma staging. Methods: One hundred adult glaucoma patients—half with suspect or mild glaucoma, and half with moderate or severe—from five clinics performed four 24-2 visual field tests during a single visit, two with the Humphrey Field
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An Automated Visual Psychophysics Method to Measure Visual Function in Swine Preclinical Animal Model Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Francesca Barone, Irina Bunea, Kristi Creel, Ruchi Sharma, Juan Amaral, Arvydas Maminishkis, Kapil Bharti
Purpose: The aim of this study was to develop and validate a test to assess visual function in pigs using the visual psychophysics contrast sensitivity function. Methods: We utilized a touchscreen along with a pellet reward dispenser to train three Göttingen pigs on a visual psychophysics test and determined their contrast sensitivity function. Images with different contrast resolutions were used as
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Association of Long-Term Exposure to Ambient Air Pollution With the Risk of Acute Primary Angle Closure Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Na Wu, Wenming Shi, Xinghuai Sun
Purpose: The purpose of this study was to investigate the association between long-term exposure to ambient air pollutants and the risk of acute primary angle closure (APAC). Methods: Two hundred eighty-one (281) patients with APAC and 730 age- and sex-matched controls hospitalized between January 2017 and December 2019 were enrolled in this retrospective case-control study. Residential exposure to
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The 6-Item Vision-Related Quality of Life and Limitations Questionnaire: Evaluation of Psychometric Properties Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Vera Linde Dol, Anselm B. M. Füermaier, Ton A. J. Roelofs, Anne C. L. Vrijling, Joost Heutink, Nomdo M. Jansonius
Purpose: We developed the Vision-related Quality of life and Limitations Questionnaire (VQL-6), a screening instrument to signal a need for additional care resulting from reduced vision-related quality of life in patients with chronic ophthalmic diseases. The aim of the present study was to evaluate psychometric properties. Methods: A Dutch population-based sample of 2032 participants (mean age, 55
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Perspectives of Patients and Professionals on Implementing a Computer Adaptive Vision-Related Quality of Life Outcome (CAT-EyeQ) in Clinical Practice Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 T. P. Rausch-Koster, H. P. A. van der Aa, F. D. Verbraak, G. H. M. B. van Rens, R. M. A. van Nispen
Purpose: The CAT-EyeQ is a computer adaptive test (CAT) which measures vision-related quality of life in patients having exudative retinal diseases. The aim of this study is to investigate the usability of the CAT-EyeQ in clinical practice and identify potential barriers and facilitators for implementation (problem analysis). Methods: Patients and health care professionals participated in the study
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Long-Term Porcine Retina Explants as an Alternative to In Vivo Experimentation Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Maria Weller, Brigitte Müller, Knut Stieger
Purpose: The porcine retina represents an optimal model system to study treatment approaches for inherited retinal dystrophies owing to close anatomical similarities to the human retina, including a cone enriched visual streak. The aim of this work was to establish a protocol to keep explants in culture for up to 28 days with good morphological preservation. Methods: Two to four retina explants per
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Contamination Profile of Different Formulations of Silicone Oil Tamponade Before and After Intraocular Permanence for Rhegmatogenous Retinal Detachment Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-03-01 Carlo Bellucci, Nicolò Riboni, Guido Ricciotti, Federico Spadini, Andrea Pasquali, Maurizio Rossi, Stefano Gandolfi, Erika Ribezzi, Enrico Marraffa, Federica Bianchi, Maria Careri, Paolo Mora
Purpose: The purpose of this study was to search for contaminants in silicone oil tamponades removed from eyes treated for retinal detachment, and to correlate chemical results with some clinical/functional parameters of the considered eyes. Methods: We examined a sequential cohort of eyes grouped according to the tamponade received: (1) Siluron2000 (S2), (2) RS-OIL ECS5000 (S5), and (3) Densiron Xtra
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Unraveling the Intricate Network of lncRNAs in Corneal Epithelial Wound Healing: Insights Into the Regulatory Role of linc17500 Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Qiongjie Cao, Dewei Peng, Jiao Wang, Peter S. Reinach, Dongsheng Yan
Purpose: Epigenetic mechanisms orchestrate a harmonious process of corneal epithelial wound healing (CEWH). However, the precise role of long non-coding RNAs (lncRNAs) as key epigenetic regulators in mediating CEWH remains elusive. Here, we aimed to elucidate the functional contribution of lncRNAs in regulating CEWH. Methods: We used a microarray to characterize lncRNA expression profiling during mouse
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A Catalog of Patent Applications Published in 2023 Related to Ophthalmology and Vision Science Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Guillaume Stern, Jonathan J. Mallett
Abstract not available
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Predicting the Extent of Damage in the Humphrey Field Analyzer 24-2 Visual Fields Using 10-2 Test Results in Patients With Advanced Glaucoma Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Ryo Asaoka, Kenji Sugisaki, Toshihiro Inoue, Keiji Yoshikawa, Akiyasu Kanamori, Yoshio Yamazaki, Shinichiro Ishikawa, Kenichi Uchida, Aiko Iwase, Makoto Araie, for Advanced Glaucoma Study Members in Japan Glaucoma Society
Purpose: To predict Humphrey Field Analyzer 24-2 test (HFA 24-2) results using 10-2 results. Methods: A total of 175 advanced glaucoma eyes (175 patients) with HFA 24-2 mean deviation (MD24-2) of < −20 dB were prospectively followed up for five years using HFA 10-2 and 24-2 (twice and once in a year, respectively). Using all the HFA 24-2 and 10-2 test result pairs measured within three months (350
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Assessment of Causality Between Diet-Derived Antioxidants and Primary Open-Angle Glaucoma: A Mendelian Randomization Study Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Kun Xiong, Qi'ao Zhang, Huiyan Mao, Nathan Congdon, Yuanbo Liang
Purpose: This study aimed to investigate the genetic causal relationships among diet-derived circulating antioxidants, primary open-angle glaucoma (POAG), and glaucoma-related traits using two-sample Mendelian randomization (MR). Methods: Genetic variants associated with diet-derived circulating antioxidants (retinol, ascorbate, β-carotene, lycopene, α-tocopherol, and γ-tocopherol) were assessed as
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Two Disparity Channels in Human Visual Cortex With Different Contrast and Blur Sensitivity Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Milena Kaestner, Yulan D. Chen, Caroline Clement, Alex Hodges, Anthony M. Norcia
Purpose: Our goal is to describe the contrast and blur sensitivity of multiple horizontal disparity subsystems and to relate them to the contrast and spatial sensitivities of their monocular inputs. Methods: Steady-state visual evoked potential (SSVEP) amplitudes were recorded in response to dynamic random dot stereograms (DRDSs) alternating at 2 Hz between zero disparity and varying magnitudes of
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Effect of Decentration, Rotation, and Tilt on Objective Optical Quality of Plate Haptic Toric Intraocular Lenses in the Early Postoperative Period Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Yingying Hong, Yang Sun, Houyi Liu, Yinghong Ji
Purpose: This study aimed to determine the influence of decentration, rotation, and tilt on objective optical quality of plate haptic toric intraocular lenses (tIOLs). Methods: The area ratio of modulation transfer function (MTF), strehl ratio of point spread function (PSF), and higher order aberrations (HOAs) for 3 mm and 5 mm pupil diameter (PD) were evaluated at postoperative 1 month. The retroillumination
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Deep Learning and Machine Learning Algorithms for Retinal Image Analysis in Neurodegenerative Disease: Systematic Review of Datasets and Models Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Tyler Bahr, Truong A. Vu, Jared J. Tuttle, Raymond Iezzi
Purpose: Retinal images contain rich biomarker information for neurodegenerative disease. Recently, deep learning models have been used for automated neurodegenerative disease diagnosis and risk prediction using retinal images with good results. Methods: In this review, we systematically report studies with datasets of retinal images from patients with neurodegenerative diseases, including Alzheimer's
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Development of a Machine-Learning–Based Tool for Overnight Orthokeratology Lens Fitting Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Seongbong Koo, Wook Kyum Kim, Yoo Kyung Park, Kiwon Jun, Dongyoung Kim, Ik Hee Ryu, Jin Kuk Kim, Tae Keun Yoo
Purpose: Orthokeratology (ortho-K) is widely used to control myopia. Overnight ortho-K lens fitting with the selection of appropriate parameters is an important technique for achieving successful reductions in myopic refractive error. In this study, we developed a machine-learning model that could select ortho-K lens parameters at an expert level. Methods: Machine-learning models were established to
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Simulating the Effects of Partial Neural Conduction Delays in the Visual Evoked Potential Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Enyam K. A. Morny, Julia Haldina, Sven P. Heinrich
Purpose: The purpose of this study was to understand the double peaks or broadening of P100 observed in some cases of optic neuritis by inducing conduction delays in healthy eyes through stimulus luminance manipulation in analogy to the perceptual Pulfrich effect. Methods: Checkerboard pattern reversal visual evoked potentials (VEPs) with check sizes of 0.8 degrees, 0.4 degrees, and 0.2 degrees were
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In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Yanzhi Zhao, Yirui Zhu, Yange Yan, Hongwei Yang, Jingchao Liu, Yongan Lu, Yingjie Li, Guofu Huang
Purpose: Validation of the feasibility of novel acoustic radiation force optical coherence elastography (ARF-OCE) for the evaluation of biomechanical enhancement of the in vivo model of keratoconus by clinical cross-linking (CXL) surgery. Methods: Twelve in vivo rabbit corneas were randomly divided into two groups. Both groups were treated with collagenase type II, and a keratoconus model was obtained
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Disparities in Eye Care Utilization Among Refugee and Migrant Populations Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Ivan A. Copado, Shahin Hallaj, Bharanidharan Radha Saseendrakumar, Sally L. Baxter
Purpose: In this cross-sectional study, we examined refugee/migrant participants' health and eye care utilization compared to controls in San Diego County. Methods: Data were collected from electronic health records (EHRs) at UCSD Health-affiliated medical centers. Through a manual review of EHRs, eligibility criteria to identify a cohort were developed. A total of 64 refugee/migrant participants and
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Chorioretinal Atrophy Growth After Voretigene Neparvovec Retinotopically Is Connected to Retinal Functional Rescue Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Krunoslav Stingl, Melanie Kempf, Ronja Jung, Katarina Stingl
Purpose: Chorioretinal atrophy growth after voretigene neparvovec has been reported recently with its positive correlation with successful treatment. This finding raised the question on long-term effects and the etiology of the chorioretinal atrophy. Methods: Using local retinal functional diagnostics, we tested whether the atrophy growth is connected to the initial local functional improvement after
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Detection of TTR Amyloid in the Conjunctiva Using a Novel Fluorescent Ocular Tracer Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Julie Pilotte, Alex S. Huang, Sami Khoury, Xiaowei Zhang, Ali Tafreshi, Peter Vanderklish, Stella T. Sarraf, Jose S. Pulido, Tatyana Milman
Background: Transthyretin amyloidosis (ATTR) is a significant cause of cardiomyopathy and other morbidities in the elderly and Black Americans. ATTR can be treated with new disease-modifying therapies, but large shortfalls exist in its diagnosis. The objective of this study was to test whether TTR amyloid can be detected and imaged in the conjunctiva using a novel small-molecule fluorescent ocular
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Healthcare Resource Utilization and Costs in an At-Risk Population With Diabetic Retinopathy Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Vivian Rajeswaren, Vivian Lu, Hongan Chen, Jennifer L. Patnaik, Niranjan Manoharan
Purpose: Several investigators have suggested the cost-effectiveness of earlier screening, management of risk factors, and early treatment for diabetic retinopathy (DR). We aimed to evaluate the extent of health care utilization and cost of delayed care by insurance type in a vulnerable patient population. Methods: A retrospective analysis of patients with DR was conducted using electronic medical
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Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Poonam Naik, Rhonda Grebe, Imran A. Bhutto, D. Scott McLeod, Malia M. Edwards
Purpose: Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration with multifactorial etiology and no well-established treatment. A model recapitulating the hallmarks would serve as a key to understanding the underlying pathologic mechanisms better. In this report, we further characterized our previously reported subretinal sodium iodate model of GA. Methods: Retinal degeneration
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Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Filippo Bonelli, Fabiola Campestre, Romina Mayra Lasagni Vitar, Ibrahim Halil Demirsoy, Philippe Fonteyne, Giulio Ferrari
Purpose: This study aims to assess the efficacy of two aprepitant formulations (X1 and X2), in a preclinical model of dry eye disease (DED) induced by benzalkonium chloride (BAK). Methods: Two aprepitant formulations were tested on 7 to 8-week-old male mice for their efficacy. In vivo corneal fluorescein staining assessed epithelial damage as the primary end point on days 0, 3, 5, 7, 9, 12, and 14
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ZEISS PLEX Elite 9000 Widefield Optical Coherence Tomography Angiography as Screening Method for Early Detection of Retinal Hemangioblastomas in von Hippel–Lindau Disease Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Stefan J. Lang, Michelle Dreesbach, Yannik Laich, Andreas Glatz, Daniel Boehringer, Viviane Grewing, Marianne Fritz, Felicitas Bucher, Wolf A. Lagrèze, Peter M. Maloca, Thomas Reinhard, Clemens Lange, Hansjuergen Agostini, Michael Reich
Purpose: To evaluate early detection of retinal hemangioblastomas (RHs) in von Hippel–Lindau disease (VHLD) with widefield optical coherence tomography angiography (wOCTA) compared to the standard of care in ophthalmologic VHLD screening in a routine clinical setting. Methods: We conducted prospective comparisons of three screening methods: wOCTA, standard ophthalmoscopy, and fluorescein angiography
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Characteristics of Visual Function in Children With Cerebral Palsy and Intellectual Disabilities in Urban Beijing Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Jun Tao, Rui Hao, Yatu Guo, Wei Zhang
Objective: To investigate ocular development and the characteristics of visual function among children with cerebral palsy (CP) and intellectual disabilities in Beijing's Chaoyang District schools. Methods: A total of 160 children (320 eyes) with CP and intellectual disabilities, including 86 males and 74 females aged between 6 and 18 years old (median, 13.5 years), were included in this study. A total
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Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Jinding Pang, Zhenyu Wei, Leying Wang, Xiaoyan Guo, Qiankun Chen, Yuan Wei, Yan Peng, Zijun Zhang, Yuheng Zhang, Jiamin Liu, Zhen Cheng, Zhiqun Wang, Yang Zhang, Kexin Chen, Xizhan Xu, Xinxin Lu, Qingfeng Liang
Purpose: To investigate the relationship between Acanthamoeba genotypes, clinical manifestations, and outcomes in Acanthamoeba keratitis (AK) patients. Methods: This retrospective study included 159 culture-confirmed AK patients. Patients’ data were collected, including demographics, initial diagnosis, treatments, and clinical features. The genotype of Acanthamoeba was identified through sequencing
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Efficiency, Precision, Validity, and Reliability of GlauCAT-Asian Computerized Adaptive Tests in Measuring Glaucoma-Related Quality of Life Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-02-01 Eva K. Fenwick, Ryan E. K. Man, Belicia Lim, Mani Baskaran, Monisha Nongpiur, Chelvin C. A. Sng, Jayant Venkatramani Iyer, Rahat Husain, Shamira Perera, Tina Wong, Jin Rong Low, Olivia Shimin Huang, Katherine Lun, Bao Sheng Loe, Tin Aung, Ecosse L. Lamoureux
Purpose: To determine the efficiency, precision, and agreement of GlauCAT-Asian and its corresponding validity and reliability. Methods: In this cross-sectional study, 219 participants (mean ± standard deviation age, 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects were recruited from glaucoma clinics in Singapore. Participants answered seven computerized
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Vitreous Biomarkers for Proliferative Vitreoretinopathy Prognostication in Patients Undergoing Primary Retinal Detachment Repair Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Abtin Shahlaee, Daphne Yang, Jamie Chen, Ricardo Lamy, Jay M. Stewart
Purpose: To compare baseline levels of exploratory biomarkers in the vitreous fluid of patients with primary retinal detachment who subsequently develop proliferative vitreoretinopathy (PVR) versus those who do not. Methods: In this exploratory case-control study, we evaluated the baseline protein biomarker levels from a biobank containing the vitreous fluid of patients who had undergone primary pars
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Acrizanib as a Novel Therapeutic Agent for Fundus Neovascularization via Inhibitory Phosphorylation of VEGFR2 Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Xiaoyu Tang, Kaixuan Cui, Peiqi Wu, Andina Hu, Matthew Fan, Xi Lu, Fengmei Yang, Jicheng Lin, Shanshan Yu, Yue Xu, Xiaoling Liang
Purpose: The present study aimed to evaluate the effect of acrizanib, a small molecule inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2), on physiological angiogenesis and pathological neovascularization in the eye and to explore the underlying molecular mechanisms. Methods: We investigated the potential role of acrizanib in physiological angiogenesis using C57BL/6J newborn
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Retinal Vascular Measurements and Mortality Risk: Evidence From the UK Biobank Study Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Mayinuer Yusufu, Yutong Chen, Alimu Dayimu, Gabriella Bulloch, Shanshan Jin, Algis J. Vingrys, Lei Zhang, Xianwen Shang, Danli Shi, Mingguang He
Purpose: This study aimed to investigate the association between quantitative retinal vascular measurements and the risk of all-cause and premature mortality. Methods: In this population-based cohort study using the UK Biobank data, we employed the Retina-based Microvascular Health Assessment System to assess fundus images for image quality and extracted 392 retinal vascular measurements per fundus
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Deep Learning Identifies High-Quality Fundus Photographs and Increases Accuracy in Automated Primary Open Angle Glaucoma Detection Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Benton Chuter, Justin Huynh, Christopher Bowd, Evan Walker, Jasmin Rezapour, Nicole Brye, Akram Belghith, Massimo A. Fazio, Christopher A. Girkin, Gustavo De Moraes, Jeffrey M. Liebmann, Robert N. Weinreb, Linda M. Zangwill, Mark Christopher
Purpose: To develop and evaluate a deep learning (DL) model to assess fundus photograph quality, and quantitatively measure its impact on automated POAG detection in independent study populations. Methods: Image quality ground truth was determined by manual review of 2815 fundus photographs of healthy and POAG eyes from the Diagnostic Innovations in Glaucoma Study and African Descent and Glaucoma Evaluation
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Texture-Based Radiomic SD-OCT Features Associated With Response to Anti-VEGF Therapy in a Phase III Neovascular AMD Clinical Trial Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Sudeshna Sil Kar, Hasan Cetin, Sunil K. Srivastava, Anant Madabhushi, Justis P. Ehlers
Purpose: The goal of this study was to evaluate the role of texture-based baseline radiomic features (Fr) and dynamic radiomics alterations (delta, FΔr) within multiple targeted compartments on optical coherence tomography (OCT) scans to predict response to anti–vascular endothelial growth factor (VEGF) therapy in neovascular age-related macular degeneration (nAMD). Methods: HAWK is a phase 3 clinical
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Impact of Neurolens Use on the Quality of Life in Individuals With Headaches: A Randomized Double-Masked, Cross-Over Clinical Trial Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Vivek Labhishetty, Jesus Cortes, Corina van de Pol, Ville Maanpaa, Aric Plumley, Neha Amin, Jason Hurley, Tausha Barton, Troy White, Rob Szeliga, J Mathis Dixon, David Grosswald, Jon Knutson, Heavin Maier
Purpose: Vision-related disorders, such as refractive errors and binocular vision issues, can cause headaches. The current study evaluates the impact of Neurolens (NL) on individuals with headaches, assessed using the Headache Impact Test (HIT) questionnaire. Methods: Subjects (18–60 years) with good stereoacuity and a HIT score of ≥56 points were enrolled. Each subject wore both control lens and NL
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Combining Riboflavin/UV-A Light and Rose Bengal/Green Light Corneal Cross-Linking Increases the Resistance of Corneal Enzymatic Digestion Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 M. Enes Aydemir, Nikki L. Hafezi, Nan-Ji Lu, Emilio A. Torres-Netto, Mark Hillen, Carina Koppen, Farhad Hafezi
Purpose: The purpose of this study was to determine if concurrent riboflavin/UV-A light (RF/UV-A) and rose Bengal/green light (RB/green) epi-off PACK-CXL enhances corneal resistance to enzymatic digestion compared to separate chromophore/light treatments. Methods: Ex vivo porcine corneas were allocated as follows. Group A corneas were soaked with riboflavin (RF) and were either not irradiated (A1,
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Visual Field Evaluation Using Zippy Adaptive Threshold Algorithm (ZATA) Standard and ZATA Fast in Patients With Glaucoma and Healthy Individuals Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Pinaz Nasim, Ramesh S. Ve, Neetha I. R. Kuzhuppilly, Preethi Naik, Shonraj Ballae Ganeshrao, Paul H. Artes
Purpose: To evaluate visual fields obtained with Zippy Adaptive Threshold Algorithm (ZATA) Standard and ZATA Fast from patients with glaucoma and healthy individuals. Methods: Fifty-five patients with glaucoma (median mean deviation [MD], −7.6 dB; interquartile range [IQR], −15.3 to −2.6 dB) and 22 healthy participants (median MD, −0.6 dB; IQR, −1.7 to 0.2 dB) performed ZATA Standard and ZATA Fast
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Biometry-Based Technique for Determining the Anterior Scleral Thickness: Validation Using Optical Coherence Tomography Landmarks Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Satish Kumar Gupta, Rohit Dhakal, Pavan Kumar Verkicharla
Purpose: Considering the potential role of anterior scleral thickness (AST) in myopia and the ubiquitous use of optical biometers, we applied and validated a biometry-based technique for estimating AST using optical coherence tomography (OCT) landmarks. Methods: The AST was determined across four meridians in 62 participants (aged 20–37 years) with a swept-source OCT and a noncontact optical biometer
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Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Svenja Rebecca Sonntag, Britta Klein, Ralf Brinkmann, Salvatore Grisanti, Yoko Miura
Purpose: To investigate fluorescence lifetime of mouse models of age-related macular degeneration (AMD) by fluorescence lifetime imaging ophthalmoscopy (FLIO). Methods: Two AMD mouse models, apolipoprotein E knockout (ApoE−/−) mice and NF-E2-related factor-2 knockout (Nrf2−/−) mice, and their wild-type mice underwent monthly ophthalmic examinations including FLIO from 3 months of age. After euthanasia
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A Bayesian Hierarchical Spatial Longitudinal Model Improves Estimation of Local Macular Rates of Change in Glaucomatous Eyes Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Erica Su, Vahid Mohammadzadeh, Massood Mohammadi, Lynn Shi, Simon K. Law, Anne L. Coleman, Joseph Caprioli, Robert E. Weiss, Kouros Nouri-Mahdavi
Purpose: Demonstrate that a novel Bayesian hierarchical spatial longitudinal (HSL) model improves estimation of local macular ganglion cell complex (GCC) rates of change compared to simple linear regression (SLR) and a conditional autoregressive (CAR) model. Methods: We analyzed GCC thickness measurements within 49 macular superpixels in 111 eyes (111 patients) with four or more macular optical coherence
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Efficacy of Morning Versus Evening Latanoprost/Timolol Fixed Combination for Open-Angle Glaucoma and Ocular Hypertension: A Randomized Clinical Trial Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Hui Feng, Dong Han, Wensheng Lu, Guangxian Tang, Hengli Zhang, Sujie Fan, Aiguo Lv, Jing Jiang, Qing Zhang, Ye Zhang, Kai Cao, Zhi Li, Shuning Li
Purpose: To compare the efficacy of morning and evening latanoprost/timolol fixed-combination (LTFC) dosing in patients with primary open-angle glaucoma (POAG) and ocular hypertension. Methods: In this double-blind, randomized clinical trial, 63 untreated Chinese patients with POAG and ocular hypertension were enrolled. All patients received LTFC and were randomized (1:1) to group 1, morning (8 AM)
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Spatial Vision Inequalities: A Literature Review of the Impact of Place on Vision and Eye Health Outcomes Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Patrice M. Hicks, Kirsten Simmons, Paula Anne Newman-Casey, Maria A. Woodward, Angela R. Elam
“Neighborhood and built environment” is one of the five domains of social determinants of health that has been outlined by Healthy People 2030, and this domain impacts an individual's well-being, health, and quality of life. Social risk factors (SRFs) in the neighborhood and built environment domain include unstable or unsafe housing, poor access to transportation, lack of green spaces, pollution,
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Real-Time Imaging of Single Retinal Cell Apoptosis in a Non-Human Primate Ocular Hypertension Model Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Takeshi Ishikawa, Naoki Kishi, Yoshiko Shimizu, Takao Fujimura, Takao Yamazaki
Purpose: To evaluate the feasibility of using DARC (detection of apoptosing retinal cells) technology as a biomarker for preclinical assessment of glaucomatous damage in a non-human primate (NHP) model of ocular hypertension (OHT). Methods: Elevated intraocular pressure (IOP) was induced by applying a laser to the trabecular meshwork in each eye of NHPs. Changes in DARC counts in the retina, identified
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LIMBARE: An Advanced Linear Mixed-Effects Breakpoint Analysis With Robust Estimation Method With Applications to Longitudinal Ophthalmic Studies Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 TingFang Lee, Joel S. Schuman, Maria de los Angeles Ramos Cadena, Yan Zhang, Gadi Wollstein, Jiyuan Hu
Purpose: Broken stick analysis is a widely used approach for detecting unknown breakpoints where the association between measurements is nonlinear. We propose LIMBARE, an advanced linear mixed-effects breakpoint analysis with robust estimation, especially designed for longitudinal ophthalmic studies. LIMBARE accommodates repeated measurements from both eyes and over time, and it effectively addresses
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Cone-Driven, Geniculocortical Responses in Canine Models of Outer Retinal Disease Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Huseyin O. Taskin, Jacqueline Wivel, Gustavo D. Aguirre, William A. Beltran, Geoffrey K. Aguirre
Purpose: Canine models of inherited retinal degeneration are used for proof of concept of emerging gene and cell-based therapies that aim to produce functional restoration of cone-mediated vision. We examined functional magnetic resonance imaging (MRI) measures of the postretinal response to cone-directed stimulation in wild-type (WT) dogs, and in three different retinal disease models. Methods: Temporal
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Perceptual Learning Based on the Lateral Masking Paradigm in Anisometropic Amblyopia With or Without a Patching History Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Yusong Zhou, Yunsi He, Yu Jia, Lei Feng, Qingqing Ye, Zixuan Xu, Yijing Zhuang, Ying Yao, Rengang Jiang, Xiaolan Chen, Yangfei Pang, Wentong Yu, Yun Wen, Junpeng Yuan, Jinrong Li, Jing Liu
Purpose: Perceptual learning (PL) has shown promising performance in restoring visual function in adolescent amblyopes. We retrospectively compared the effect of a well-accepted PL paradigm on patients with anisometropic amblyopia with or without a patching therapy history (patching therapy [PT] group versus no patching therapy [NPT] group). Methods: Eighteen PT and 13 NPT patients with anisometropic
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Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Qinyi Gu, Qinxiang Zheng, Xiaoyu Zhang, Lei Lin, Saiqing Li, Fangwei Chen, Xian Zhang, Lijing L. Yan, Wei Chen
Purpose: We aimed to analyze the trends and patterns in outpatient health service treatment of dry eye disease (DED) using real-world data from Yinzhou District in China. Methods: The Yinzhou Health Information System is a comprehensive database including electronic medical records from 277 medical institutions representing over 1.64 million residents. We extracted outpatient records from January 1
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Visualization of Optic Nerve Structural Patterns in Papilledema Using Deep Learning Variational Autoencoders Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Jui-Kai (Ray) Wang, Edward F. Linton, Brett A. Johnson, Mark J. Kupersmith, Mona K. Garvin, Randy H. Kardon
Purpose: To visualize and quantify structural patterns of optic nerve edema encountered in papilledema during treatment. Methods: A novel bi-channel deep-learning variational autoencoder (biVAE) model was trained using 1498 optical coherence tomography (OCT) scans of 125 subjects over time from the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) and 791 OCT scans of 96 control subjects
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Corneal Epithelial Remodeling Induced by Photorefractive Keratectomy Enhancement After Small-Incision Lenticule Extraction Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Yiming Ye, Xiangtao Hou, Na Yu, Pei Chen, Jing Zhuang, Keming Yu
Purpose: To assess changes in corneal epithelial thickness (ET) within 9-mm diameter cornea after photorefractive keratectomy (PRK) retreatment after small-incision lenticule extraction (SMILE). Methods: A total of 28 eyes of 19 patients with mean spherical equivalent of −1.30 ± 0.60 D who underwent retreatment after SMILE were included in this retrospective study. ET mapped across a 9-mm diameter
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Ultra-Widefield Imaging of the Retinal Macrovasculature in Parkinson Disease Versus Controls With Normal Cognition Using Alpha-Shapes Analysis Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Justin P. Ma, Cason B. Robbins, Emma Pead, Sarah McGrory, Charlene Hamid, Dilraj S. Grewal, Burton L. Scott, Emanuele Trucco, Tom J. MacGillivray, Sharon Fekrat
Purpose: To investigate retinal vascular characteristics using ultra-widefield (UWF) scanning laser ophthalmoscopy in Parkinson disease (PD). Methods: Individuals with an expert-confirmed clinical diagnosis of PD and controls with normal cognition without PD underwent Optos California UWF imaging. Patients with diabetes, uncontrolled hypertension, glaucoma, dementia, other movement disorders, or known
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Which OCT Measure of the Optic Nerve Head Improves Fastest? Towards Optimizing Early Detection of Resolving Papilledema in Children Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Tanmay V. Majmudar, Heather E. Moss, Robert A. Avery
Purpose: Optical coherence tomography (OCT) has been used to monitor papilledema. This study aims to determine which OCT-derived measures of the optic nerve head (ONH) detect resolving papilledema in children faster than standard OCT measures. Methods: Children (≤18 years of age) with papilledema who completed optic nerve SD-OCT pretreatment and had evidence of treatment response on one or more follow-up
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Field Evaluation of a Mobile App for Assisting Blind and Visually Impaired Travelers to Find Bus Stops Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Shrinivas Pundlik, Prerana Shivshanker, Tim Traut-Savino, Gang Luo
Purpose: GPS location-based navigation apps are insufficient to aid blind and visually impaired (BVI) travelers for micro-navigation tasks, such as finding the exact location of bus stops. The resulting large gaps could lead to BVI travelers missing their bus. We evaluated the ability of a signage detection mobile app, All_Aboard, to guide BVI travelers precisely to the bus stops compared to Google
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Predicting Implantable Collamer Lens Vault Using Machine Learning Based on Various Preoperative Biometric Factors Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Yu Di, Huihui Fang, Yan Luo, Ying Li, Yanwu Xu
Purpose: To predict the vault size after Implantable Collamer Lens (ICL) V4c implantation using machine learning methods and to compare the predicted vault with the conventional manufacturer's nomogram. Methods: This study included 707 patients (707 eyes) who underwent ICL V4c implantation at the Department of Ophthalmology, Peking Union Medical College Hospital, from September 2019 to January 2022
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Astigmatism Influences Quantitative and Qualitative Analysis in Optical Coherence Tomography Angiography Imaging Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Lourdes Vidal-Oliver, Roberto Gallego-Pinazo, Rosa Dolz-Marco
Purpose: The purpose of this paper was to study the influence of astigmatism in optical coherence tomography angiography (OCTA) images in a quantitative and qualitative analysis. Methods: This was a prospective, cross-sectional study. We included 110 eyes of 110 patients: 20 eyes without astigmatism and 90 eyes with astigmatism ≥0.5 diopters (D). We performed a macula centered OCTA as a reference image
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Capabilities and Limitations of Student-Led Free Vision Screening Programs in the United States Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Nirupama Devanathan, Melanie Scheive, Baraa S. Nawash, Amrish Selvam, Alec Murphy, McKenna Morrow, Shruti Anant, Nickolas Chen, Elizabeth A. Martin, Jessica S. Kruger, Chi-Wah Rudy Yung, Thomas V. Johnson
Purpose: The Consortium of Student-Led Eye Clinics (CSLEC), founded in 2021, administered a comprehensive survey to document the types of services, most common diagnoses, and follow-up care protocols offered by student-led free vision screening programs (SLFVSP) in the United States. Methods: An 81-question institutional review board (IRB)-approved survey was administered to student-led vision screening
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Outcomes of Telerehabilitation Versus In-Office Training With Magnification Devices for Low Vision: A Randomized Controlled Trial Transl. Vis. Sci. Technol. (IF 3.0) Pub Date : 2024-01-02 Ava K. Bittner, John E. Kaminski, Patrick D. Yoshinaga, John D. Shepherd, Tiffany L. Chan, Alexis G. Malkin, Ashley Deemer, Micaela Gobeille, Stacy J. Thoene, Annemarie Rossi, Nicole C. Ross, for the BeST-AID Study Team
Purpose: An evidence basis is lacking but needed to compare reading ability outcomes after magnification device training remotely via telerehabilitation versus in office. Methods: A multicenter randomized controlled trial at academic centers and vision rehabilitation private practices randomized 61 visually impaired adults to telerehabilitation or in-office training 1 to 4 months after dispensing new