-
Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-14 Hang Ren, Yueyue Sun, Yanting Li, Xianbin Yuan, Bo Jiang, Wei Zhang, Gaoqin Liu, Peirong Lu
To explore the role of coagulation and fibrinolytic factors, and the potential mechanism of platelet aggregation in the pathogenesis of retinal vein occlusion.Coagulation and fibrinolytic parameter...
-
Optical Coherence Tomography Angiography in Vogt–Koyanagi–Harada Patients: A Systematic Review and Meta-Analysis Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-08 Ruyu Liang, Jiawei Geng, Hai Jiang, Siyan Jin, Xia Wang, Xiaoli Liu
To describe the choroidal retinal microvascular system in Vogt-Koyanagi-Harada (VKH) subjects and furnish additional proof for the early authentication and treatment of VKH suffers.From the beginni...
-
Visual Outcome and Fluid Changes Between Eyes With Polypoidal Choroidal Vasculopathy Receiving Biosimilar CKD-701 or Reference Ranibizumab Therapy: A Post Hoc Analysis of a Phase 3 Randomized Clinical Trial Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-07 Ki Tae Nam, Cheolmin Yun, Young Joo Lee, Mihyun Choi, Dongwan Kang, Jaeryung Oh
To compare the visual outcome and fluid features of a proposed biosimilar, CKD-701, versus the reference ranibizumab in eyes with polypoidal choroidal vasculopathy (PCV).This was a post hoc analysi...
-
MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-07 Peihong Wang, Lixiong Gao, Tianju Ma, Zi Ye, Zhaohui Li
Fibrotic cataracts, including anterior subcapsular cataract (ASC) as well as posterior capsule opacification (PCO), are a common vision-threatening cause worldwide. Still, little is known about the...
-
Repeatability of Rod-Mediated Dark Adaptation Testing in Normal Aging and Early and Intermediate Age-Related Macular Degeneration Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-04 Cynthia Owsley, Thomas A. Swain, Gerald McGwin Jr., Mary Margaret Bernard, Mark E. Clark, Christine A. Curcio
The vulnerability of rod photoreceptors in aging and early and intermediate age-related macular degeneration (AMD) has been well documented. Rod-mediated dark adaptation (RMDA) is a measure of the ...
-
BMSC Alleviates Dry Eye by Inhibiting the ROS-NLRP3-IL-1β Signaling Axis by Reducing Inflammation Levels Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-07 Dandan Zhao, Hongxia Zhao, Yang He, Meixia Zhang
Bone marrow mesenchymal stem cells (BMSC) have multiple biological functions and are widely involved in regulating inflammatory diseases, tissue repair and regeneration. However, the mechanism of t...
-
Examination of Subbasal Nerve Plexus and Central Corneal Stromal Microstructure in Subjects With Congenital Aniridia, Using in Vivo Confocal Laser Scanning Microscopy Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-05 Anita Csorba, Kitti Kormányos, Mária Csidey, Annamária Náray, Klaudia Kovács, Orsolya Németh, Krisztina Knézy, Mária Bausz, Andrea Szigeti, Dorottya Szabó, Marta Corton, Kálmán Tory, Zoltán Zsolt Nagy, Achim Langenbucher, Erika Maka, Nóra Szentmáry
During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial cell differentiation an...
-
Evaluation of Optical Coherence Tomography Angiography Findings in Pars Planitis and Multiple Sclerosis Associated Intermediate Uveitis in Remission Curr. Eye Res. (IF 2.0) Pub Date : 2024-03-03 Berru Yargi-Ozkocak, Cigdem Altan, Burcu Kemer-Atik, Berna Basarir
To evaluate the microvasculature during remission in patients with pars planitis (PP-IU) and multiple sclerosis-associated intermediate uveitis (MS-IU) using optical coherence tomography angiograph...
-
Quantitative Analysis of the Vasculature and Cone Photoreceptors in Subjects With Diabetes Without Diabetic Retinopathy Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-26 Danae A. Johnson, Nathan Doble, Stacey S. Choi
To characterize any differences in the vasculature and cone photoreceptor packing geometry (CPG) between subjects with diabetes without/no diabetic retinopathy (NDR) and healthy controls.Eight NDR ...
-
Deep Learning based Retinal Vessel Caliber Measurement and the Association with Hypertension Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-26 Shenshen Yan, Jie Zhao, Haicheng She, Yimeng Jiang, Fangfang Fan, Guangzhengao Yang, Jinqiong Zhou, Jia Jia, Yan Zhang, Li Zhang
To develop a highly efficient and fully automated method that measures retinal vessel caliber using digital retinal photographs and evaluate the association between retinal vessel caliber and hyper...
-
Naevi Characterization Using Hyperspectral Imaging: A Pilot Study Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-26 Madeleine Selvander, Jan Alexander, Diego Guenot
The prevalence of choroidal naevi is common and has been found to be up to 10%. Little is known regarding the optical properties of choroidal naevi. A novel hyperspectral eye fundus camera was used...
-
Comparing Intraocular Pressure, Ocular Blood Flow, and Retinal Nerve Fiber Layer Thickness in Early and Chronic Hypertensives With Normotensives Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-22 Geeta Behera, Ritu Kunnilethu, Suresh Chidambaram Thirunavukarasu, Ramesh Jayaraman, Thanikachalam Subramanyam, Anandaraja Subramanian
To compare blood pressure (BP), intraocular pressure (IOP), ophthalmic artery flow (OAF) velocity, retinal nerve fiber layer (RNFL) thickness, and visual fields in newly diagnosed hypertension (HT)...
-
Anterior Chamber and Retinal Morphological Changes During Accommodation in Different Age Ranges Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-20 María Arcas-Carbonell, Elvira Orduna-Hospital, Guisela Fernández-Espinosa, María Mechó-García, José Juan Castro-Torres, Ana Sánchez-Cano
Accommodation mainly affects the lens, a structure of the eyeball that degrades with age. The aim of this work was to study the morphological changes of different ocular structures during accommoda...
-
Influence of Lens Thickness on Accuracy of Kane, Hill-RBF 3.0, Barrett Universal II, Emmetropia Verifying Optical, and Pearl-DGS Formulas in Eyes with Nonhigh Myopia and High Myopia Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-16 Yuxi Chen, Yanwen Fang, Jing Zhao, Wenwen He, Bo Ma, Xiangjia Zhu
To investigate the influence of lens thickness (LT) on accuracy of Kane, Hill-RBF 3.0 Barrett Universal II (BUII), Emmetropia Verifying Optical (EVO), and Pearl-DGS formulas in eyes with different ...
-
Selective ILM Staining and Safety of Two Vital Dyes During a Human-Like Pars Plana Vitrectomy Ex Vivo in Porcine Eyes Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-16 Claudio Gatto, Laura Giurgola, Umberto Rodella, Orietta Rossi, Claudia Honisch, Paolo Ruzza, Eugenio Ragazzi, Jana D’Amato Tóthová
An ideal dye for intraocular use should effectively stain the target tissue while being easy to apply and remove. Additionally, it should not have any adverse effects resulting from prolonged conta...
-
Primary Lacrimal Sac Tumors with Extension into Vicinity: Outcomes with Endoscopy-Assisted Modified Weber-Ferguson’s Approach Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-14 Leilei Zhang, Wenyue Zhang, Lunhao Li, XueRu Liu, Yi Ding, Fan Yang, Mohammad Javed Ali, Caiwen Xiao
To evaluate the outcomes of endoscopy-assisted modified Weber-Ferguson’s approach in the management of primary lacrimal sac tumors with extension into the neighboring tissues.A retrospective interv...
-
Association of Systemic Markers of Inflammation with Signs and Symptoms of Dry Eye Disease and Sjogren’s Syndrome in the Dry Eye Assessment and Management (DREAM©) Study Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-12 Marium H. Hashemi, Julian L. Ambrus Jr., Abhay A. Shukla, Di Zhu, Gui-Shuang Ying, Penny A. Asbell, Dry Eye Assessment and Management (DREAM) Study Research Group
To evaluate the possible role of systemic inflammation in dry eye disease (DED) via systemic inflammatory marker associations with DED signs and symptoms, and an analysis of a subgroup with Sjogren...
-
The Use of Ologen Implant in Childhood Glaucoma Surgeries: A Review Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-12 Ahmed S. Elwehidy, Joseph Toma, Dina Abd Elfattah, Abdelrahman M. Elhusseiny
This study assesses the effectiveness and safety of using Ologen implants (Aeon Astron Europe BV, Leiden, The Netherlands) as an adjunctive therapy in childhood glaucoma surgeries.We systematically...
-
Changes in Subfoveal Choroidal Thickness after Orthokeratology in Myopic Children: A Systematic Review and Meta-Analysis Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-02 Jie Xiao, Xinghui Pan, Chenting Hou, Qing Wang
This study aimed to synthesize the variations in subfoveal choroidal thickness (SFCT) observed at different follow-up intervals in myopic children undergoing orthokeratology treatment.Relevant arti...
-
Characterizing the Robustness of Distinct Clinical Assessments in Identifying Dry Eye Condition of Animal Models Curr. Eye Res. (IF 2.0) Pub Date : 2024-02-01 Hsiu-Hui Hsieh, Yu-An Chang, Szemin Chan, Zhi-Qian Lin, Chung-Tien Lin, Fung-Rong Hu, Kai-Feng Hung, Yi-Chen Sun
The study aims to characterize the robustness of distinct clinical assessments in identifying the underlying conditions of dry eye disease (DED), with a specific emphasis on the involvement of conj...
-
Comparison of Pre- and Post-DMEK Keratometry and Total Keratometry Values for IOL Power Calculations in Eyes Undergoing Triple DMEK Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-22 Neal Rangu, David L. Cooke, Aman Mittal, Thomas Reinhard, Katrin Wacker, Achim Langenbucher, Jascha A. Wendelstein, Kamran M. Riaz
To evaluate prediction accuracy of pre- and post-DMEK keratometry (K) and total keratometry (TK) values for IOL power calculations in Fuchs endothelial corneal dystrophy (FECD) eyes undergoing DMEK...
-
Automatic Identification and Severity Classification of Retinal Biomarkers in SD-OCT Using Dilated Depthwise Separable Convolution ResNet with SVM Classifier Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-22 Adithiya S V, Dharani Bai G, Rajiv Raman
Diagnosis of Uveitic Macular Edema (UME) using Spectral Domain OCT (SD-OCT) is a promising method for early detection and monitoring of sight-threatening visual impairment. Viewing multiple B-scans...
-
Investigation of Mitochondrial Homeostasis Changes in Lens Epithelium of High-Myopic Cataract Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Chenghao Sun, Pengfei Li, Guowei Zhang, Wenjing Geng, Congyu Wang, Sijie Bao, Xi Liu, Min Ji, Huaijin Guan
High myopia is demonstrated as a pathogenic factor for nuclear cataract. The main mechanism of high-myopia cataracts (HMC) is oxidative damage, which causes mitochondrial homeostasis imbalance. Thi...
-
Scutellarin Alleviates Diabetic Retinopathy via the Suppression of Nucleotide-Binding Oligomerization Domain (NOD)-Like Receptor Pyrin Domain Containing Protein 3 Inflammasome Activation Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Lina Yang, Zheming Li, Jian Fang
Diabetic retinopathy, a prevalent complication of diabetes, represents the leading cause of vision loss and blindness among middle-aged and elderly populations. Recent research has demonstrated the...
-
Chalazion Treatment: A Concise Review of Clinical Trials Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Behzod Tashbayev, Xiangjun Chen, Tor Paaske Utheim
A chalazion is one of the most common eye conditions presenting as a mass lesion of the eyelids. It is seen in all age groups. Chalazion is a non-inflammatory process and develops due to retained s...
-
Contrast Adaptation in Pseudophakic Patients with Macular Disorders Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Hakan Kaymak, Kai Neller, Birte Graff, Achim Langenbucher, Berthold Seitz, Hartmut Schwahn, Karsten Klabe
To learn whether contrast adaptation, induced by positive spherical defocus, is compromised by macular disorders such as age-related macular degeneration (AMD) or epiretinal membranes (ERM) and to ...
-
Short-Term Effect of Rose Bengal Photodynamic Therapy (RB-PDT) on Collagen I, Collagen V, NF-κB, LOX, TGF-β and IL-6 Expression of Human Corneal Fibroblasts, In Vitro Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Ning Chai, Tanja Stachon, Tim Berger, Zhen Li, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry
To investigate collagen I, collagen V, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), lysyl oxidase (LOX), transforming growth factor β1 (TGF-β1) and interleukin-6 (IL-6) e...
-
Clinical and Morphological in Vivo Confocal Microscopy Findings following a Modified Biphasic Higher Fluence Transepithelial Corneal Crosslinking Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Bin Liu, Xumin Shang, Xiuxian Tan, Shunrong Luo, Xie Fang, Zhiwen Xie, Xianwen Xiao, Huan He, Lan Gong, Huping Wu, Zhirong Lin
Purpose: To compare the refractive efficacy and morphological changes in the cornea following a novel biphasic higher fluence transepithelial corneal crosslinking (BI-TE-CXL) and transepithelial co...
-
Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Wenyi Zhang, Jing Yao, Chen Chen, Jianming Wang, Aiyi Zhou
To investigate the expression, source, role, and mechanism of Fetuin-B (FETUB) in diabetic retinopathy (DR).ELISA and immunofluorescence were used to analyze the concentration of FETUB in plasma, a...
-
Randomized Controlled Trial of Patching versus Dichoptic Stimulation Using Virtual Reality for Amblyopia Therapy Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Yasmine Meqdad, Mohamed El-Basty, Ahmed Awadein, Jylan Gouda, Dina Hassanein
Purpose: To compare the outcomes of patching to dichoptic stimulation using virtual reality (VR) in moderate and severe amblyopia.Methods: This study was conducted on 86 subjects with unilateral an...
-
Relation Between Corneal Dendritic Cell Density and Tear Film Stability in Patients with Epidemic Keratoconjunctivitis Associated Dry Eye Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Chengfang Zhu, Xianwen Xiao, Xie Fang, Lei Yan, Shunrong Luo, Xumin Shang, Zhiwen Xie, Nuo Dong, Huan He, Rongrong Zong, Lan Gong, Huping Wu, Zhirong Lin
To clarify the ocular surface features of patients with recent history of epidemic keratoconjunctivitis (EKC) and the relation between corneal dendritic cells (DCs) and ocular discomfort.Normal con...
-
Development of a Web-Based Algorithm for Understanding the Intraocular Lens-Based Surgery in Stable and Progressing Keratoconus for Non-Specialist Ophthalmologists Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Mayank A. Nanavaty, Zahra Ashena, Ingrid Bekono-Nessah, Jennie Harding
To propose an algorithm to facilitate lens-based surgery in keratoconus.A literature review was performed to prepare a software algorithm based on cone location, stability, best spectacle-corrected...
-
Association between Fundus Tessellation and Contrast Sensitivity in Myopic Eyes Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Dianjun Jiang, Ning Guo, Xiaotong Lv, Yu Li, Yu Han, Mingzhen Yuan, Changbin Zhai, Wei Zhang, Fengju Zhang
To assess the association of fundus tessellation with contrast sensitivity, Quality of Vision questionnaire, and other factors at five years postcorneal refractive surgery.This is a cross-sectional...
-
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT): Subanalysis of Referral to Ophthalmology Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-18 Lisa A. Hark, Weijie Violet Lin, Sitara Hirji, Prakash Gorroochurn, Jason D. Horowitz, Daniel F. Diamond, Lisa Park, Qing Wang, James D. Auran, Stefania C. Maruri, Desiree R. Henriquez, Tarun Sharma, Ives Valenzuela, Jeffrey M. Liebmann, George A. Cioffi, David S. Friedman, Noga Harizman
The Manhattan Vision Screening and Follow-up Study aims to provide access to eye care for underserved populations, detect native rates of ocular pathology, and refer participants with eye disease t...
-
Refractive Changes After Horizontal Strabismus Surgery Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-15 Yu Bi, Shibin Lin
To investigate the changes in refractive status after surgery in patients with horizontal strabismus and high refractive error.This was a prospective study of patients with horizontal strabismus an...
-
The Long-Term Effect on Dry Eye of Posterior Approach Ptosis Surgery Vs. Upper Eyelid Blepharoplasty Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-15 Ofira Zloto, Idan Alcalay, Bar Klain, Guy Ben Simon
To examine the long-term effect of combined blepharoplasty and Müller muscle-conjunctival resection (MMCR) compared to an upper blepharoplasty procedure on dry eye syndrome.This is a Prospective co...
-
Expression of the SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension Eyes of Nonhuman Primate and Human Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-11 Difang Sun, Zongyi Zhan, Bin Wang, Ting Liu, Minbin Yu, Yuqing Lan, Jun Li
Coronavirus disease 2019 is a disease caused by the novel severe acute respiratory syndrome coronavirus 2. The double-positive of angiotensin-converting enzyme 2 and transmembrane protease serine t...
-
Reduction of ETV1 is Identified as a Prominent Feature of Age-Related Cataract Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-10 Xiaodi Qiu, Shaohua Zhang, Youmeng Zhang, Lei Cai, Dan Li, Yi Lu
To identify the inactive genes in cataract lenses and explore their function in lens epithelial cells (LECs).Lens epithelium samples obtained from both age-related cataract (ARC) patients and norma...
-
Sex Differences in the Prevalence of Meibomian Gland Dysfunction: A Mini Review Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-09 Sara T. Nøland, Morten S. Magnø, Tor P. Utheim, Xiangjun Chen
In this review, we aimed to investigate the literature on sex-specific prevalence of meibomian gland dysfunction (MGD) and to determine whether women or men are more at risk for MGD.A search was co...
-
Factors Associated With Laboratory Test Negativity Following a Transition in Specimen Collection in Microbial Keratitis Cases Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-05 Keith D. Miller, Avi Toiv, Callie Deng, Ming-Chen Lu, Leslie M. Niziol, Jenna N. Hart, Eric Sherman, Shahzad I. Mian, Paul R. Lephart, Alan Sugar, Linda Kang, Maria A. Woodward
Negative laboratory results make targeting microbial keratitis treatment difficult. We investigated factors associated with laboratory negativity in patients with microbial keratitis in the context...
-
Need to Increase the Number of Intense Pulsed Light (IPL) Treatment Sessions for Patients with Moderate to Severe Meibomian Gland Dysfunction (MGD) Patients Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-04 Yang Lu, Lan Gong, Yue Yin
To evaluate whether patients with moderate–to–severe meibomian gland dysfunction (MGD) will benefit from increasing the number of intense pulsed light (IPL) treatment sessions.Ninety Asian adult wi...
-
Optical Coherence Tomography Features of Macular Hyperpigmented Lesions without Intraretinal Hyperreflective Foci in Age-Related Macular Degeneration Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Mehdi Emamverdi, Abbas Habibi, Maryam Ashrafkhorasani, Muneeswar G. Nittala, Shin Kadomoto, SriniVas R. Sadda
To evaluate the optical coherence tomography (OCT) features of hyperpigmented lesions in the absence of intraretinal hyperreflective foci (IHRF) on OCT in eyes with age-related macular degeneration...
-
Toric Intraocular Lens versus Peripheral Corneal Relaxing Incisions for Astigmatism between 0.75 and 2.5 Diopters: 5-Years Outcomes Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Ritika Mukhija, Aneesha Fonseca, Steven Borkum, Paul Frattaroli, Emma Barbon, Mayank A. Nanavaty
To compare 5-year outcomes of toric intraocular lens (tIOL) or peripheral corneal relaxing incision (PCRI) for correction of keratometric astigmatism (KA) between 0.75 and 2.5 diopters (D).Setting:...
-
The Use of Digital PCR for the Diagnosis of Demodex Blepharitis Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Na An, Xiuhong Dou, Ni Yin, Haiqing Lu, Jie Zheng, Xianning Liu, Hua Yang, Xiuping Zhu, Xianghua Xiao
This was a pilot study to evaluate the efficacy of digital polymerase chain reaction detection of Demodex in eyelid margin swabs for the diagnosis of Demodex blepharitis. This study aims to explore...
-
Systemic Inflammatory Mediator Levels in Non-Proliferative Diabetic Retinopathy Patients with Diabetic Macular Edema Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Wenyi Peng, Mingmei Zhang, Xianglong Yi
To study the systemic inflammatory mediator levels in non-proliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and explore the correlation between systemic inflammat...
-
A Comparison of Culture Results and Visual Acuity in Contact Lens Related Microbial Keratitis Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Jenna N. Hart, Ming-Chen Lu, Breanna M. Tracey, Keith D. Miller, Paul R. Lephart, Shahzad I. Mian, Maria A. Woodward
Evaluate the effect of corneal and contact lens-related (CLR) culture results on visual acuity (VA) in patients with microbial keratitis (MK).MK patients with corneal and CLR cultures were identifi...
-
NEDD4L Promotes IκBα Ubiquitination and Degradation in the Pathogenesis of Diabetic Retinopathy Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Li Cui, Jingxue Ma
The dysregulation of NF-κB signaling activity plays an important role in the pathogenesis of diabetic retinopathy (DR). This study explored the association between NEDD4L and IκBα in DR.The rat mod...
-
Association of Tear Cytokine Ratios with Symptoms and Signs of Dry Eye Disease: Biomarker Data from the Dry Eye Assessment and Management Study Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Cindy S. Zhao, Yineng Chen, Gui-Shuang Ying, Penny A. Asbell, for the Dry Eye Assessment and Management (DREAM) Study Group
To assess the relationship between tear inflammatory cytokine ratios (CRs) and signs and symptoms of dry eye disease (DED) to investigate the possible use of tear CRs, which may better address the ...
-
Diabetes-Induced Changes of the Rat ERG in Relation to Hyperglycemia and Acidosis Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Andrey V. Dmitriev, Alexander A. Dmitriev, Robert A Linsenmeier
To understand the mechanism of changes in the c-wave of the electroretinogram (ERG) in diabetic rats, and to explore how glucose manipulations affect the c-wave.Vitreal ERGs were recorded in contro...
-
Role of Inhibiting Inflammation of LC3-Associated Phagocytosis in Dry Eye Disease Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Sasa Zhang, Xing Liu, Cui Li, Qian Wang, Shanshan Yang, Xudong Peng, Liting Hu, Guiqiu Zhao, Jing Lin
To confirm the expression and investigate the role of LC3-associated phagocytosis (LAP) in dry eye disease (DED).The DED model of mice was established by scopolamine subcutaneous injection in a low...
-
A Novel Primary Porcine Retinal Pigment Epithelium Cell Model with Preserved Properties Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-03 Dinna Zhou, Anne Petersen, Julia Adelöf, Malin Hernebring, Madeleine Zetterberg
To establish an ethical, reliable, and expandable retinal pigment epithelial (RPE) cell model with maintained RPE properties compatible with multifarious assays.RPE cells from abattoir-obtained por...
-
Integrative Analysis of miRNA and circRNA Expression Profiles and Interaction Network in HSV-1-Infected Primary Corneal Epithelial Cells Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-02 Yu-Hong Cui, Chao-Qun Liu, Xi-Ling Song, Wan-Zhao Yi, Qi Liu, Jing-min Liu, Ya-Ni Wu, Jian-Ying Chen, Lv-Jun Yang, Hui-Ying He, Jing Meng, Hong-Wei Pan
Circular RNAs (circRNAs) are products of alternative splicing with roles as competitive endogenous RNAs or microRNA sponges, regulating gene expression and biological processes. However, the involv...
-
In Vivo Corneal Confocal Microscopy for Detecting Corneal Nerve Fiber Changes in Patients with Different Types of Optic Neuritis: A Cross-Sectional Study Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-02 Rui Zhao, Leying Wang, Fei Chen, Hongjuan Liu, Chunli Chen, Jing Zhang, Sitong Guo, Qingfeng Liang, Libin Jiang
Optic neuritis (ON), a demyelinating disease of the central nervous system, is often a precursor manifestation of neuromyelitis optica spectrum disorders (NMOSD) or multiple sclerosis (MS). Reduced...
-
Mimicking TGFBI Hot-Spot Mutation Did Not Result in Any Deposit Formation in the Zebrafish Cornea Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-02 Fulya Yaylacıoğlu Tuncay, Beril Talim, Pervin Rukiye Dinçer
Mutations in transforming growth factor beta-induced (TGFBI) protein are associated with a group of corneal dystrophies (CDs), classified as TGFBI-associated CDs, characterized by deposits in the c...
-
Fluocinolone Acetonide Loaded Chitosan Nanofiber Scaffolds for Treatment of Ocular Disorders: In Vitro Characterization, Ex-Vivo Corneal and Ex-Vivo Scleral Evaluation Curr. Eye Res. (IF 2.0) Pub Date : 2024-01-01 Zeeshan Patel, Sankalp Gharat, Munira Momin
Drugs administered in the ocular region need to overcome ocular barriers without permanently damaging the ocular tissues. Moreover, ocular disorders of the posterior segment are more difficult to t...
-
Assessment of Peripapillary Retinal Nerve Fiber Layer Optical Density Ratios in Healthy Eyes Using Optical Coherence Tomography with Different Analytical Radii Curr. Eye Res. (IF 2.0) Pub Date : 2023-12-28 Binyao Chen, Shirong Chen, Jianling Yang, Hongxi Wang, Mingzhi Zhang
To explore the characteristics and determinants of peripapillary retinal nerve fiber layer (RNFL) optical density (OD) by optical coherence tomography (OCT) in healthy eyes with varied analytical r...
-
Differences in Oxygen-Induced Retinopathy Susceptibility Between Two Sprague Dawley Rat Vendors: A Comparison of Retinal Transcriptomes Curr. Eye Res. (IF 2.0) Pub Date : 2023-12-28 Haeyeon Lee, Mandkhai Molomjamts, Heidi Roehrich, Sydney Gudvangen, Chanel Asuncion, Michael K. Georgieff, Phu Tran, Linda K. McLoon, Ellen C. Ingolfsland
To determine the retinal transcriptomic differences underlying the oxygen-induced retinopathy phenotypes between Sprague Dawley rat pups from two commonly used commercial vendors. This will allow u...
-
Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency Curr. Eye Res. (IF 2.0) Pub Date : 2023-12-28 Ana Boto de los Bueis, Cristina Vidal Arranz, Almudena Del Hierro-Zarzuelo, David Díaz Valle, Rosalía Méndez Fernández, María Isabel Gabarrón Hermosilla, José Manuel Benítez del Castillo, Mariano García-Arranz
To determine the safety and feasibility of human autologous adipose tissue-derived adult mesenchymal stem cells (ASCs) for ocular surface regeneration in patients with bilateral limbal stem-cell de...
-
CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract Curr. Eye Res. (IF 2.0) Pub Date : 2023-12-28 Fenghua Cui, Zhonghua Sun, Xueyan Zhang, Cuijuan Liu
Dysregulated circular RNAs (circRNAs) is involved in the pathogenesis of age-related cataract (ARC). Here, this study aimed to explore the function and mechanism of circMAP3K4 in ARC.Human lens epi...
-
Suitability of Slaughterhouse-Acquired Pig Eyes as Model Systems for Refractive Ultraviolet and Infrared Femtosecond Laser Research Curr. Eye Res. (IF 2.0) Pub Date : 2023-12-26 Omar Abdelrahman, Marius Topka, Yao Zhang, Antonia Bock, Johannes Lörner, Rebecca Jungbauer, Thilo Hotfiel, Friedrich Paulsen, Christian M. Hammer
To elucidate whether it is feasible to use porcine eyes from scalded, abattoir-acquired animals for refractive femtosecond laser research.An infrared laser (FS 200) and an ultraviolet laser (protot...