-
Long term follow up of brolucizumab in macular neovascularization. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-29 Maria Ludovica Ruggeri,Lisa Toto,Rossella D'Aloisio,Alberto Quarta,Raffaella Aloia,Patrizio Venturoni,Chiara De Nicola,Emanuele Doronzo,Matteo Gironi,Annamaria Porreca,Marta Di Nicola,Rodolfo Mastropasqua
PURPOSE To evaluate functional and anatomical changes in type 1 and type 2 naïve MNV patients treated with brolucizumab injections up to one year of treatment (week 48). METHODS 38 eyes of 38 patients with active MNV were enrolled at the Ophthalmology Clinic of the University "G. d'Annunzio", Chieti-Pescara, Italy. All patients were scheduled for brolucizumab intravitreal injections as per label, according
-
The p.C759F variant in USH2A is a pathogenic mutation: systematic literature review and meta-analysis of 667 genotypes. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-28 Ji Hoon Han,Francesca Cancellieri,Irene Perea-Romero,Carmen Ayuso,Mathieu Quinodoz,Carlo Rivolta
INTRODUCTION Although the p.C759F (c.2276G>T, p.Cys759Phe) variant in the USH2A gene has been identified in association with retinal degeneration by several authors, its pathogenicity has been questioned once by the publication of two unaffected homozygotes from a single family. MATERIALS AND METHODS To gain insights into this apparent discrepancy, we examined 87 research articles reporting on patients
-
Simple technique for stabilizing toric intraocular lens during removal of ophthalmic viscosurgical device. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-28 Tsutomu Ohashi,Akio Fujiya,Maiko Yoshida,Takashi Kojima
INTRODUCTION To describe a simple technique for the implantation of toric intraocular lenses (IOLs) with increased stability during ophthalmic viscosurgical device (OVD) removal. METHODS The technique was performed on 20 eyes with 20 patients (mean age: 77.9 ± 9.21 years). The patients had cataract surgery with implantation of a single-piece, acrylic IOL (AcrySof Toric IOL, SN6A; Alcon Laboratories
-
The Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients with Geographic Atrophy (OMEGA) Study: Design and Baseline Characteristics (OMEGA report 1). Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-28 Georg Ansari,Nils Schärer,Hanna Camenzind Zuche,Chrysoula Gabrani,Philipp Anders,Kristina Pfau,Philippe Valmaggia,Andrea Giani,Marieh Esmaeelpour,Taffeta Chingning Yamaguchi,Christian F Prünte,Peter M Maloca,Leopold Schmetterer,Hendrik P N Scholl,Maximilian Pfau
INTRODUCTION The aim of this study is to describe the design and the participants' baseline characteristics of a prospective natural-history study of geographic atrophy (GA) secondary to age-related macular degeneration. METHODS The optical coherence tomography (OCT) and microperimetry biomarker evaluation in patients with GA (OMEGA) study was conducted at a tertiary referral center (ClinicalTrials
-
The impact of parental myopia and high myopia on the hyperopia reserve of preschool children. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-21 Jianing Pu,Yuxin Fang,Zhen Zhou,Wei Chen,Jianping Hu,Shanshan Jin,Xinli Liu,Lihua Wang,Jingjing Feng,Huan Tong,Shanshan Xing,Yonghong Jiao
INTRODUCTION The aim of this study was to explore the association between parental myopia and high myopia with children's refraction and ocular biometry in large-scale Chinese preschool children from the Beijing Hyperopia Reserve Study. SUBJECTS/METHODS This cross-sectional kindergarten-based study enrolled children aged 3-6 years. Cycloplegic refraction, axial length (AL), and corneal radius (CR)
-
Identification of Cuproptosis-related circRNA-miRNA-mRNA Network in Laser-induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-related Macular Degeneration. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-21 Min Zhang,Jiali Wu,Yafang Wang,Xiaoling Wan,Haiyun Liu,Xiaodong Sun
INTRODUCTION To investigate the molecular alterations of cuproptosis-related genes and to construct the cuproptosis-related circRNA-miRNA-mRNA networks in neovascular age-related macular degeneration (nAMD). METHODS The transcriptional profiles of laser-induced choroid neovascularization (CNV) mouse models and nAMD patient samples were obtained from sequencing and from the GEO database (GSE146887)
-
Comparison of Clarus and Optomap Ultra-widefield Imaging Systems Before and After EVO-ICL Implantation in High Myopia. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-17 Xiaosong Han,Yijia Xu,Zhi Chen,Ruoyan Wei,Weiming Yang,Zhiqiang Yu,Xiaoying Wang,Meiyan Li,Xingtao Zhou
INTRODUCTION To investigate the features of imaging differences between Clarus and Optomap ultra-widefield imaging systems after implantable collamer lens (ICL) implantation. METHODS Non-randomized controlled study. 92 eyes of 46 consecutive patients were enrolled. Full-scale ophthalmological examinations were conducted preoperatively. All patients underwent Clarus (CLARUS 500, Carl Zeiss, Dublin,
-
Single versus Double Preserflo MicroShunt Implantation in Glaucoma Patients: A Retrospective Cohort Study. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-16 Thomas Dervos,Konstantin Gugleta,Hendrik P N Scholl,Zisis Gatzioufas,Tim J Enz
Introduction The aim of this study is to describe and evaluate double Preserflo MicroShunt implantation as a modified micro-invasive glaucoma surgery technique and to retrospectively compare the outcomes in a cohort of glaucoma patients with single or double implantation. Materials and Methods A retrospective data analysis of 57 glaucoma patients who consecutively underwent Preserflo implantation was
-
Inverted Internal Limiting Membrane Flap VS. ILM Peeling for<400μm Macular Hole: a meta-analysis and systematic review. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-06 Pingping Li,Lu Li,Jianhua Wu
PURPOSE The inverted internal limiting membrane (ILM) flap technique was initially developed for the closure of large macular holes (MH). However, its efficacy in treating small holes has been a matter of debate. This study aimed to compare the anatomical and visual outcomes of vitrectomy (PPV) combined with the inverted ILM flap and ILM peeling in cases of small and medium-sized MHs. METHODS A meta-analysis
-
Discovery of clinical manifestations in spontaneous glaucoma suspect non-human primates. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-04 Xu Jia,Ziyu Yu,Jian Wu,Simeng Hou,Yifan Du,Yingting Zhu,Zhidong Li,Shu Tu,Ling Zhao,Wenru Su,Ningli Wang,Yehong Zhuo
INTRODUCTION The primary aim of this study was to assess the longitudinal changes in RNFL thickness and relative ONH parameters using spectral-domain optical coherence tomography (SD-OCT) in living eyes of non-human primates with spontaneous glaucoma. METHODS Totally 9 macaque subjects underwent a standard fundus photo and OCT examination, including 3 adult monkeys with stable elevated intraocular
-
Association between dietary consumption of vitamin B1 and advanced age-related macular degeneration: a cross-sectional observational study in NHANES 2005-2008. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-03 Qingqing Zheng,Ting Shen,Mengyue Xu,Lingtong Tan,Zeqi Shen,Chaoyang Hong
INTRODUCTION One of the most common conditions that causes permanent blindness globally is age-related macular degeneration (AMD). The purpose of the present study was to determine the association between vitamin B1 consumption and the prevalence of late AMD in a representative US sample. METHODS Data from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2008 were utilized
-
Photoreceptor outer segment loss at the macular hole border: clinical characteristics and surgical prognosis. Ophthalmic Res. (IF 2.1) Pub Date : 2023-11-03 Biying Qi,Yanping Yu,Xiaohan Yang,Ke Zhang,Xijin Wu,Xinbo Wang,Xiao Feng,Qinlang Jia,Wu Liu
INTRODUCTION During macular hole (MH) formation, the vitreofoveal traction may lead to foveal neural tissue avulsion and consequent photoreceptor loss. However, the clinical significance of the photoreceptor outer segment disruption at the MH border remains unclear. This study aims to investigate the clinical features and surgical outcomes of MHs with photoreceptor outer segment disruption at the MH
-
Early Vitrectomy for Endophthalmitis: Are EVS Guidelines Still Valid? Ophthalmic Res. (IF 2.1) Pub Date : 2023-10-19 Parsa Panahi,Nasser Mirzakouchaki-Borujeni,Omid Pourdakan,J Fernando Arévalo
Background Endophthalmitis, a potentially sight-threatening condition, remains a challenge for ophthalmologists worldwide. The Endophthalmitis Vitrectomy Study (EVS) conducted in 1995 compared vitrectomy and intravitreal antibiotic injections to intravitreal antibiotic injections alone for acute post cataract surgery and secondary intraocular lens (IOL) endophthalmitis, setting treatment guidelines
-
Retinal Capillary Nonperfusion in Preclinical Diabetic Retinopathy. Ophthalmic Res. (IF 2.1) Pub Date : 2023-10-11 Torcato Santos,Ana Rita Santos,Ana Catarina Almeida,Ana Cláudia Rocha,Débora Reste-Ferreira,Inês Pereira Marques,António Cunha-Vaz Martinho,Luís Mendes,Katharina Foote,José Cunha-Vaz
INTRODUCTION To identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetic (T2D) patients with preclinical retinopathy identified by Ultra-Widefield Fundus Photography (UWF-FP). METHODS A cross-sectional observational study. All patients underwent UWF-FP 200° examinations with OPTOS California (Optos, Dunfermline, UK) and Cirrus AngioPlex® spectral-domain
-
Sex difference in the association between depression and adherence to recommended dilated eye examinations among patients with diabetes: Findings from National Health and Nutrition Examination Survey. Ophthalmic Res. (IF 2.1) Pub Date : 2023-10-11 Zhe Zhong,Yaying Lin,Li Zhong,Xi Yu,Aihong Xie
INTRODUCTION The relationship between depression and adherence to regular dilated fundus examination (DFE) in patients with diabetes remains unclear. This study aimed to assess the association between depression and adherence to annual or biennial DFE among individuals with diabetes. METHODS In this cross-sectional study, we used the National Health and Nutrition Examination Survey database from 2005
-
A Short-Time Real-World Study of Two Perfluoro Propane Tamponade Methods in Pars Plana Vitrectomy for Retinal Detachment. Ophthalmic Res. (IF 2.1) Pub Date : 2023-10-09 Shumei Tan,Sefei Wu,Jinhong Miao,Jing Han,Wei Jin,Dan Li,Shuang Cui,Xiaohui Wan,Li Zhang,Ting Yao,Chun Zhang,Changguan Wang,Jinping Hu
INTRODUCTION This real-world study evaluated the efficacy, safety, and operative parameters of two perfluoropropane (C3F8) tamponade methods combined with pars plana vitrectomy (PPV) for retinal detachment(RD). METHODS A retrospective study of 132 patients (132 eyes) with RD (pure C3F8 in 38 eyes, mixed C3F8 in 94 eyes). All eyes underwent PPV with C3F8 tamponade and were followed up for at least 3
-
Occurrence of corneal staining after cataract surgery with and without chitosan-N-acetylcysteine eye drops. Ophthalmic Res. (IF 2.1) Pub Date : 2023-10-05 Stefan Palkovits,Andreas Schlatter,Manuel Ruiss,Stefan Georgiev,Johannes Zeilinger,Caroline Pilwachs,Oliver Findl
PURPOSE To evaluate the prevalence of ocular surface damage assessed by corneal staining scores right after cataract surgery and whether it can be prevented using chitosan-N-acetylcysteine (C-NAC) eye drops. METHODS We included patients scheduled for routine cataract surgery. Each patient was randomly assigned to one of three groups. Patients in group 1 underwent routine cataract surgery with no additional
-
Deep Learning application to detect glaucoma with a mixed training approach: public database and expert-labeled glaucoma population. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-30 Florencia Cellini,Deborah Nixhoralvid Caamano Diaz,Belen Carrasco,Jose R Juberias,Carolina Ossa,Ramon Bringas,Francisco De La Fuente,Pablo Franco,David Coronado,Jose Carlos Pastor
INTRODUCTION Artificial Intelligence techniques are considered a real possibility to identify different ocular diseases such as glaucoma. They usually require large databases with accurate information that is not easy to obtain. This paper presents an approach based on the use of data from public databases, which have many images but also strong limitations, added to a database labeled by experts.
-
Diagnostic accuracy of Automated Diabetic Retinopathy Image Assessment Softwares: IDx-DR and MediosAI. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-27 Andrzej Grzybowski,Divya Parthasarathy Rao,Piotr Brona,Kalpa Negiloni,Tomasz Krzywicki,Florian M Savoy
INTRODUCTION Numerous studies have demonstrated the use of Artificial Intelligence for early detection of referable diabetic retinopathy (RDR). A direct comparison of these multiple Automated DR Image Assessment Softwares(ARIA) is however challenging. We retrospectively compared the performance of two modern ARIAs, IDx-DR and Medios AI. METHODS In this retrospective-comparative study, retinal images
-
Myopic vascular changes revealed by optical tomography angiography and their association with myopic fundus manifestations. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-26 Yijia Xu,Weiming Yang,Lingling Niu,Xiaoying Wang,Xingtao Zhou,Meiyan Li
INTRODUCTION We aimed to quantify and evaluate fundal vascular changes at different severities of myopia using optical tomography angiography (OCTA) and explore their association with fundus changes captured by ultra-widefield (UWF) fundus cameras. METHODS Seventy-four participants with myopia were enrolled in the study and underwent basic ophthalmic examination, OCTA, and UWF fundus photography. Multiple
-
Corneal endothelial cell cultures from organotypic preservation of older donor corneas are suitable for advanced cell therapy. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-18 Caterina Aloy-Reverté,Francisco Bandeira,Nausica Otero,Aida Rebollo-Morell,Nuria Nieto-Nicolau,José Álvaro P Gomes,José L Güell,Ricardo P Casaroli-Marano
INTRODUCTION The purpose of this work was to evaluate the in vitro growth capacity and functionality of human corneal endothelial cells (hCEC) expanded from corneas of elderly (> 60 years) donors that were preserved using an organotypic culture method (> 15 days, 31○C) and did not meet the clinical criteria for keratoplasty. METHODS Cell cultures were obtained from prior descemetorhexis (≥ 10 mm) and
-
Evaluating the Efficacy of Polyglycolic Acid-Loading Tetrandrine Nanoparticles in the Treatment of Dry Eye. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-08 Tao Li,Juan Tang,Xiao Wu,Yu Zhang,Yangrui Du,Qilin Fang,Jiaman Li,Zhiyu Du
INTRODUCTION Dry eye disease (DED) is a multifactor-induced disease accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Traditional anti-inflammation agent corticosteroids applied in DED treatment could result in high intraocular pressure, especially in long-term treatment. Therefore, we explored a nano drug that aimed to block the formation pathway of DED which
-
The Guiding Significance of Ocular Biometry in Evaluating the Refractive Status of Preschool Children. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-04 Ya Zhang,Ming Su,Lingling Liang,Bingjie Shi,Dongmei Gong,Yidan Wu,Junying Zhang,Ming Wang
INTRODUCTIONS This study aimed to analyze the correlation between refractive status and ocular biological parameters in preschool-aged children (3-6 years old), establish a regression curve, guide the clinical judgment of children's refractive status, and improve the accuracy of refractive screening for this age group. METHODS A total of 508 children, aged 3 to 6 years, were admitted to the hospital
-
Relationship between uveitis and the differential reactivity of retinal microglia. Ophthalmic Res. (IF 2.1) Pub Date : 2023-09-04 Wenna Gao,Xuemin Jin,Pengyi Zhou,Haiyan Zhu,Kunpeng Xie,Bo Jin,Liping Du
Uveitis, a complicated group of ocular inflammatory diseases, can be affected by massive pathogenic contributors such as infection, autoimmunity and genetics. Although it is well known that many pathological changes, including disorders of the immune system and disruption of the blood retinal barrier, count much in the onset and progression of uveitis, there is a paucity of safe and effective treatments
-
Effects of elevated intraocular pressure on retinal ganglion cell density and expression and interaction of retinal aquaporin 9 and monocarboxylate transporters. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-30 Yusuke Murai,Sotaro Mori,Mina Okuda,Sentaro Kusuhara,Takuji Kurimoto,Makoto Nakamura
Introduction Astrocyte-to-neuron lactate shuttle (ANLS) plays an important role in the energy metabolism of neurons, including retinal ganglion cells (RGCs). Aquaporin 9 (AQP9), which is an aquaglyceroporin that can transport lactate, may be involved in ANLS together with monocarboxylate transporters (MCTs) to maintain RGC function and survival. This study aimed to investigate the impact of elevated
-
Changes of Optic Disc and Macular Vessel Perfusion Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiograph. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-30 Chao Li,Li Tan,Xing Xu,Shirong Chen,Chukai Huang
INTRODUCTION This study aims to investigate the changes of retinal vascular system in primary angle-closure glaucoma and acute primary angle closure by Optical Coherence Tomography Angiograph and to evaluate the diagnostic ability of changes of vessel density in different sectors and layers of optic disc and macular area in APAC and PACG. METHODS In this cross-sectional, observational study, 22 APAC
-
Modulation of AMPK significantly alters uveal melanoma tumor cell viability. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-30 Ozge Deliktas,M Emre Gedik,Irem Koc,Gurcan Gunaydin,Hayyam Kiratli
Introduction Uveal melanoma (UM) responds poorly to targeted therapies or immune-checkpoint inhibitors. AMP-activated protein kinase (AMPK) is a pivotal serine/threonine protein kinase that coordinates vital processes such as cell growth. Targeting AMPK pathway, which represents a critical mechanism mediating the survival of UM cells, may prove to be a novel treatment strategy for UM. We aimed to demonstrate
-
Clinical differences between Posner-Schlossman syndrome patients with intermittent intraocular pressure elevation and glaucomatous damage. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-25 Qian Wang,Wen Zeng,Weijuan Zeng,Yang Liu,Min Ke
INTRODUCTION Although there is abundant evidence that Posner-Schlossman syndrome (PSS) can lead to secondary glaucoma, data on the clinical differences between PSS patients with secondary glaucoma and those with intermittent intraocular pressure (IOP) elevation are sparse. METHODS This retrospective observational study included 52 patients (52 eyes) diagnosed with PSS and admitted to Zhongnan Hospital
-
Comparison of Different Internal Limiting Membrane Peeling Sizes for Idiopathic Macular Holes: A Systematic Review and Meta-Analysis. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-16 Biying Qi,Ke Zhang,Xiaohan Yang,Xijin Wu,Xinbo Wang,Wu Liu
BACKGROUND Although internal limiting membrane (ILM) peeling facilitates macular hole (MH) closure and reduces late hole reopening, it brings some detrimental consequences to the retinal microstructure and functional outcomes. So far, previous studies have not reached a consensus on the optimal ILM peeling size. OBJECTIVES The objective of this study was to evaluate the outcomes of different ILM peeling
-
Discrepancies in Vessel Density and Blood Flow Distribution in Different Areas of the Iris among Pediatric Type 1 Diabetes Mellitus and Adult Type 2 Diabetes Mellitus Patients. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-14 Lipu Cui,Ying Xiao,Yu Qian,Qiurong Lin,Zhaoyu Xiang,Zhangling Chen,Jiaqi Sun,Xinran Qin,Chenhao Yang,Haidong Zou
PURPOSE To investigate differences in iris blood flow indices between pediatric type 1 diabetes mellitus (T1DM) patients and adult type 2 diabetes mellitus (T2DM) patients. METHODS This was a cross-sectional study. Pediatric T1DM patients and healthy children were members of the Shanghai Children and Adolescent Diabetes Eye (SCADE) cohort who visited Shanghai Eye Hospital in February 2022. The adult
-
The Impact of Pregnancy on Diabetic Retinopathy: a Single-Center Study of Clinical Risk Factors. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-11 Jay Rathinavelu,Swara M Sarvepalli,Beth Bailey,David D'Alessio,Majda Hadziahmetovic
INTRODUCTION This study aimed to provide information on modifiable and non-modifiable risk factors for the progression and development of diabetic retinopathy (DR) and diabetic macular edema (DME). This retrospective chart review case-control study was designed to provide perspective on clinical variables. METHODS Single-center study analysis was completed with chart review, identifying 50 patients
-
Clinical Observation of Macular Superficial Capillary Plexus and Ganglion Cell Complex in Patients with Parkinson's Disease. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-10 Ling Zhang,Chuchu Zhuang,Yining Wang,He Wang,Guiyun Cui,Jianxin Guo
INTRODUCTION We investigated macular superficial capillary plexus (SCP) density and the thicknesses of the ganglion cell complex (GCC) in patients with Parkinson's disease (PD) and correlated them. We also observed the correlations between SCP density and clinical parameters of PD patients. The retina might be a novel biomarker of PD and will be useful in the future for the early diagnosis of PD and
-
Local Adenoviral Delivery of Vascular Endothelial Growth Factor C Induces Lymphangiogenesis in the Conjunctiva in Rabbits. Ophthalmic Res. (IF 2.1) Pub Date : 2023-08-09 Dusan Rasic,Martin Wirenfeldt,Anne Louise Askou,Thomas J Corydon,Niklas Telinius
INTRODUCTION The purpose of this study was to determine if conjunctival lymphangiogenesis can be induced using adenoviral delivery of vascular endothelial growth factor C (VEGF-C). METHODS Seventeen New Zealand white rabbits received a subconjunctival injection containing 3.5 × 107 plaque-forming units of an adenoviral vector containing the gene-encoding VEGF-C (Ad-VEGF-C). The contralateral eye was
-
Safety and Efficacy of the Phototherapeutic Keratectomy for Treatment of Recurrent Corneal Erosions: A Systematic Review and Meta-analysis. Ophthalmic Res. (IF 2.1) Pub Date : 2023-07-25 Sijing Chen,Xiaoran Chu,Chen Zhang,Zhe Jia,Liu Yang,Ruibo Yang,Yue Huang,Shaozhen Zhao
BACKGROUND Phototherapeutic Keratectomy (PTK) has been increasingly used to treat severe recurrent corneal erosion syndrome (RCES) patients who do not respond to other treatments. However, the efficacy and complication of each study are currently uncertain due to varying rates. OBJECTIVES The objective of this study was to investigate the safety and efficacy of the Phototherapeutic Keratectomy for
-
The agreement of the nomogram tool and UBM images in calculating UCP probe model in Chinese patients. Ophthalmic Res. (IF 2.1) Pub Date : 2023-07-18 Shaoyang Zheng,Dingqiao Wang,Zhihong Huang,Zhenyu Wang,Yuan Liu,Liming Chen,Ling Jin,Yuheng Tan,Mingkai Lin,Chengguo Zuo
PURPOSE To compare and explore the agreement between the nomogram tool and UBM images method to calculate the UCP probe model in Chinese glaucoma patients. METHODS Retrospective analysis of Chinese glaucoma patients who visited Zhongshan Ophthalmic Center in Guangzhou from Jan-Dec 2019 and were eligible for UCP surgery. Visual acuity, intraocular pressure (IOP), ocular axial length (AL), and horizontal
-
Distribution of the retinal microcirculation based on the morphology of peripapillary atrophy in high myopia. Ophthalmic Res. (IF 2.1) Pub Date : 2023-07-17 Wenquan Tang,Junyi Ouyang,YuLin Luo
INTRODUCTION To evaluate the retinal microvasculature of the optic nerve head and macula in high myopia (HM), investigate the association between the vascular parameters and peripapillary atrophy deformation, and assess and identify the peripapillary atrophy morphology changes during the development of HM. METHODS 167 right eyes from 167 HM patients were enrolled in this cross-sectional study. Using
-
Characteristics of hematologic parameters in young patients with retinal vein occlusion. Ophthalmic Res. (IF 2.1) Pub Date : 2023-07-10 Xiaoyun Wang,Lei Wang,Xinying Li,Shaohua Liu,Bing Liu
INTRODUCTION The aim of this study was to investigate the characteristics of hematologic parameters in young patients with retinal vein occlusion (RVO). METHODS All participants underwent routine ocular examinations and blood sample tests. Hematologic parameters obtained from a complete blood count, as well as the calculation of specific inflammatory indices, were compared between young patients with
-
Comparison of Diabetic Retinopathy Lesions Identified Using Ultrawide Field Imaging and Optical Coherence Tomography Angiography. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-28 Recivall P Salongcay,Lizzie Anne C Aquino,Claude Michael G Salva,Tunde Peto,Paolo S Silva
INTRODUCTION Optical coherence tomography (OCT) angiography (OCTA) has the potential to influence the diagnosis and management of diabetic eye disease. This study aims to determine the correlation between diabetic retinopathy (DR) findings on ultrawide field (UWF) color photography (UWF-CP), UWF fluorescein angiography (UWF-FA), and OCTA. METHODS This is a cross-sectional, prospective study. One hundred
-
Evaluation of nozzle tip damage in intraocular lens injectors with V-shaped notch. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-27 Lu Zhang,Gerd Auffarth,Sonja Schickhardt,Patrick Merz,Tamer Tandogan
Introduction Damage to the nozzle tips of IOL injectors has been associated with various adverse events and even IOL surface abnormalities after IOL implantation. In this study, nozzle tip damage of three different injector models with v-notched nozzle tips were systematically evaluated using our self-developed system - the Heidelberg Score for IOL Injector Damage. Methods Nozzle tip damage was categorized
-
Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-16 Sangwoo Moon,Jinmi Kim,Jiwoong Lee
INTRODUCTION The purpose of this study was to compare the characteristics of filtering bleb with anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT). METHODS One hundred and sixteen eyes of 103 glaucoma patients who underwent trabeculectomy with (AMT group; 85 eyes) or without AMT (control group; 31 eyes) were included. Intrableb parameters were
-
Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-16 Kanako Yasuda,Hidetaka Noma,Eri Oyama,Kosei Yanagida,Masaki Asakage,Masahiko Shimura
INTRODUCTION Little research has examined the effects of anti-vascular endothelial growth factor therapy on subfoveal choroidal thickness (SCT), choroidal blood flow, aqueous flare, and humor levels of growth and inflammatory factors in patients with macular edema due to central retinal vein occlusion (CRVO). METHODS In 58 patients with macular edema due to CRVO treated by intravitreal ranibizumab
-
Combined Trabeculotomy-Non-Penetrating Deep Sclerectomy for Glaucoma in Sturge-Weber Syndrome. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-16 Lulu Huang,Li Xu,Yixin Liu,Yijie Yang,Ning Wang,Mengyang Gu,Chengyang Sun,Yue Wu,Wenyi Guo
INTRODUCTION The aim of the study was to evaluate the efficacy and safety of combined trabeculotomy-non-penetrating deep sclerectomy (CTNS) in the treatment of Sturge-Weber syndrome (SWS) secondary glaucoma. METHODS This retrospective study reviewed cases that underwent CTNS as initial surgery for SWS secondary glaucoma at our Ophthalmology Department center from April 2019 to August 2020. Surgical
-
EZH2 Expression in Retinoblastoma: A Potential Therapeutic Target. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-13 Zhuangling Lin,Lijuan Tang,Shuxia Chen,Wenxin Zhang,Jianxian Lin,Huanhuan Gao,Ping Zhang
INTRODUCTION The enhancer of zeste homolog 2 (EZH2) is a member of the polycomb repressive complex 2 (PRC2) and is important in cell-cycle regulation. Increased expression of EZH2 has been reported in retinoblastoma (RB). The aim of the study was to determine EZH2 expression, compare this with clinicopathological parameters in RB, and assess its relationship with tumor cell proliferation. METHODS Ninety-nine
-
Comparison between Surgical Techniques Used for Revision of the Filter Bleb: A Randomized Controlled Clinical Trial. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-07 Fabio Zantut,Carolina P B Gracitelli,Sergio H Teixeira,Augusto Paranhos
INTRODUCTION/PURPOSE The aim of this study was to compare two surgical revision techniques in failed trabeculectomies after 6 months. METHODS Patients diagnosed with open-angle glaucoma who underwent trabeculectomy in at least one eye with uncontrolled intraocular pressure (IOP) after trabeculectomy performed at least 6 months before were enrolled in this prospective trial. All participants underwent
-
Inner Retinal Thickness and Vasculature in Patients with Reticular Pseudodrusen. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-02 Fritz Gerald P Kalaw,Varsha Alex,Evan Walker,Dirk-Uwe Bartsch,William R Freeman,Shyamanga Borooah
INTRODUCTION The aim of this study was to investigate retinal layer thickness and vessel density differences between patients with reticular pseudodrusen (RPD) and intermediate dry age-related macular degeneration (iAMD). METHODS Participants included in the study were patients diagnosed by retinal specialists with RPD, iAMD, and both RPD and iAMD at our academic referral center, seen from May 2021
-
Quantitatively Evaluating the Relationships between Insulin Resistance and Retinal Neurodegeneration with Optical Coherence Tomography in Early Type 2 Diabetes Mellitus. Ophthalmic Res. (IF 2.1) Pub Date : 2023-06-02 Zhaoxia Zheng,Meng Yan,Duo Zhang,Lu Li,Lina Zhang
INTRODUCTION The aim of this study was to quantitatively assess retinal neurodegenerative changes with optical coherence tomography (Cirrus HD-OCT) in type 2 diabetes mellitus (T2DM) patients without diabetic retinopathy (DR) and evaluate their relationships with insulin resistance (IR) and associated systemic indicators. METHODS 102 T2DM patients without DR and 48 healthy controls were included in
-
A Phase 3b Study for Management of Ocular Side Effects in Patients with Epidermal Growth Factor Receptor-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-31 Colin J Vize,Stella K Kim,Tim Matthews,Marian Macsai,Ryan Merrell,Sigmund Hsu,Madan Gopal Kundu,Jennifer Yoon,Emma Kennedy,Madhavi Pai,Earle Bain,Andrew B Lassman,Golnaz Moazami
INTRODUCTION The Understanding New Interventions with GBM ThErapy (UNITE) study was designed to assess the effect of prophylaxis for ocular side effects (OSEs) in patients with glioblastoma receiving the antibody-drug conjugate (ADC) depatuxizumab mafodotin. UNITE (NCT03419403) was a phase 3b, open-label, randomized, exploratory study performed at 18 research sites in 5 countries. METHODS The study
-
Copper, Lysyl Oxidase Activity, and Collagen in Aqueous Humour of Primary Glaucoma: An Association with Clinical Parameters. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-30 Sampath NikhalaShree,Ronnie Jacob George,Balekudaru Shantha,Lingam Vijaya,Konerirajapuram Natarajan Sulochana,Karunakaran Coral
INTRODUCTION To measure copper (Cu), lysyl oxidase (LOX) activity, and collagen levels in aqueous humour (AH) of primary glaucoma patients and correlate with clinical parameters. METHODS 120 patients with 40 each of primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG), and cataract controls were recruited in this case-control study. AH samples were collected during the trabeculectomy
-
Multimodal Retinal Imaging in Patients with Diabetes Mellitus and Association with Cerebrovascular Disease. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-30 Stela Vujosevic,Francesca Fantaguzzi,Recivall Salongcay,Marco Brambilla,Emanuele Torti,Laura Cushley,Celeste Limoli,Paolo Nucci,Tunde Peto
INTRODUCTION This study aimed to evaluate the association between macular optical coherence tomography angiography (OCT-A) metrics, characteristics of ultrawide field (UWF) imaging, and cerebrovascular disease in patients with diabetes mellitus (DM) with different stages of diabetic retinopathy (DR). METHODS 516 eyes of 258 DM patients were enrolled in two centers (Milan and Belfast). UWF color fundus
-
Phacoemulsification with and without iStent: A Systematic Review and Meta-Analysis of Comparative Studies. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-26 Francesca Kahale,Wassef Chanbour,Lulwa El Zein,Jason Brenner,Jae Young You,Samir Melki
BACKGROUND The iStent (Glaukos Corporation; Laguna Hills, CA, USA) is one of the minimally invasive glaucoma devices. It can be inserted at the time of phacoemulsification or as a stand-alone procedure to lower the intraocular pressure (IOP). OBJECTIVE Our aim was to conduct a systematic review and meta-analysis comparing the effect of iStent insertion at the time of phacoemulsification with phacoemulsification
-
8th International Congress of Research in Retina and Vision. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-25
xxx.
-
Data Preprocessing and Augmentation Improved Visual Field Prediction of Recurrent Neural Network with Multi-Central Datasets. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-19 Jeong Rye Park,Sangil Kim,Taehyeong Kim,Sang Wook Jin,Jung Lim Kim,Jonghoon Shin,Seung Uk Lee,Geunsoo Jang,Yuanmeng Hu,Ji Woong Lee
INTRODUCTION The purpose of this study was to determine whether data preprocessing and augmentation could improve visual field (VF) prediction of recurrent neural network (RNN) with multi-central datasets. METHODS This retrospective study collected data from five glaucoma services between June 2004 and January 2021. From an initial dataset of 331,691 VFs, we considered reliable VF tests with fixed
-
Ophthalmology Operation Note Encoding with Open-Source Machine Learning and Natural Language Processing. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-11 Yong Min Lee,Stephen Bacchi,Carmelo Macri,Yiran Tan,Robert Casson,Weng Onn Chan
INTRODUCTION Accurate assignment of procedural codes has important medico-legal, academic, and economic purposes for healthcare providers. Procedural coding requires accurate documentation and exhaustive manual labour to interpret complex operation notes. Ophthalmology operation notes are highly specialised making the process time-consuming and challenging to implement. This study aimed to develop
-
Evaluating Changes in Apparent Chord Mu after Pharmacological Pupil Dilatation. Ophthalmic Res. (IF 2.1) Pub Date : 2023-05-02 Karny Shouchane-Blum,Olga Reitblat,Judith Dadon,Irit Bahar,Ruti Sella
INTRODUCTION Preoperative measurements of apparent chord mu length above 0.6 mm have been associated with higher risks for photic phenomena after cataract surgery with multifocal intraocular lenses (MFIOLs). METHODS This retrospective study evaluated patients scheduled for elective cataract surgery at a single tertiary medical center between 2021 and 2022. Pupil diameter and apparent chord mu length
-
A novel intronic deletion in PDE6B causes autosomal recessive retinitis pigmentosa by interfering with RNA splicing Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-24 Mukhtar Ullah, Atta Ur Rehman, Marc Folcher, Adnan Ullah, Faisal Usman, Abdur Rashid, Bilal Khan, Mathieu Quinodoz, Muhammad Ansar, Carlo Rivolta
Introduction: Retinitis pigmentosa (RP) is a rare degenerative retinal disease caused by mutations in approximately seventy genes. Currently, despite the availability of large-scale DNA sequencing technologies, ~30-40% of patients still cannot be diagnosed at the molecular level. In this study, we investigate a novel intronic deletion of PDE6B, encoding the beta subunit of phosphodiesterase 6, in association
-
The efficacy and safety of air tamponade in the repair of rhegmatogenous retinal detachment: a systematic review and meta-analysis. Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-21 Anmin Zhu, Jiangni Wu, Yuan Yuan, Lan Zeng, Xiaocong Wang, Wei Tan
Background: Rhegmatogenous retinal detachment (RRD) repair by pars plana vitrectomy (PPV) combined air tamponade has many advantages compared with PPV combined gas tamponade. However, there are controversial outcomes in RRD cases involving the lower quadrants. Objective: This study aimed to evaluate the efficacy and safety of PPV combined air tamponade in patients with RRD compared with PPV combined
-
Comparisons of Handheld Retinal Imaging with Optical Coherence Tomography for the Identification of Macular Pathology in Patients with Diabetes Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-20 Cris Martin P Jacoba, Recivall P. Salongcay, Abdulrahman K Rageh, Lizzie Anne C. Aquino, Glenn P Alog, Aileen V Saunar, Tunde Peto, Paolo S. Silva
Introduction: Handheld retinal imaging cameras are relatively inexpensive and highly portable devices that have the potential to significantly expand diabetic retinopathy (DR) screening, allowing a much broader population to be evaluated. However, it is essential to evaluate if these devices can accurately identify vision-threatening macular diseases if DR screening programs will rely on these instruments
-
The Patterns of Visual Field Defects in Primary Angle-Closure Glaucoma Compared to High-Tension Glaucoma and Normal-Tension Glaucoma Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-14 Junhong Jiang, Cong Ye, Cong Zhang, Zhong Lin, Yihua Tang, Wenqing Ye, Xiang Xu, Shaodan Zhang, Fan Lu, Yuanbo Liang
Introduction: To compare the patterns of visual field (VF) defects in primary angle-closure glaucoma (PACG) to control groups of eyes with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Methods: Forty-eight eyes with PACG were enrolled, and control eyes with HTG and NTG matched for age, sex, and mean deviation (MD) of VF defect were selected. VF tests were performed using the 24-2 program
-
Downregulation of miR-210-3p attenuates high glucose-induced angiogenesis of vascular endothelial cells via targeting FGFRL1 Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-14 Tao Wen, Yiwen Hong, Yamei Cui, Jianying Pan, Yishen Wang, Yan Luo
Introduction: Vascular endothelial cell injury and angiogenesis induced by hyperglycemia are the main pathological basis of vascular complications in diabetes mellitus. The purpose of our study was to investigate the role and mechanism of miR-210-3p on high glucose-induced angiogenesis. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with high glucose (HG) to mimic the pathological
-
Multimodel imaging evidence of traction component in lamellar macular hole with epiretinal proliferation Ophthalmic Res. (IF 2.1) Pub Date : 2023-04-11 Yu-Ting Su, Chung-May Yang, Tso-Ting Lai
Introduction: To investigate the association of epiretinal traction in idiopathic lamellar macular hole (LMH) with or without lamellar hole-associated epiretinal proliferation (LHEP). Methods: A retrospective consecutive case series included 109 eyes diagnosed with LMH in a single tertiary referral center. Epiretinal traction was determined by the presence of epiretinal membrane (ERM), attached posterior