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Intravenous cyclophosphamide therapy for patients with severe ocular inflammatory diseases who failed other immunomodulatory therapies J. Ophthal. Inflamm. Infect. Pub Date : 2024-03-11 Irmak Karaca, Elaine M. Tran, SungWho Park, Albert Bromeo, Hassan Khojasteh, Anh Ngọc Tram Tran, Negin Yavari, Amir Akhavanrezayat, Cigdem Yasar, Gunay Uludag Kirimli, Ngoc Tuong Trong Than, Muhammad Hassan, Christopher Or, Hashem Ghoraba, Diana V. Do, Quan Dong Nguyen
Ocular inflammatory diseases, including scleritis and uveitis, have been widely treated with immunomodulatory therapies (IMTs) as a steroid-sparing approach. Such strategy includes conventional therapies (antimetabolites, alkylating agents, and calcineurin inhibitors) as well as biologic agents like adalimumab, infliximab, rituximab, and tocilizumab. Cyclophosphamide (CP) is an alkylating agent and
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Clinical analysis of infectious endophthalmitis following glaucoma filtration surgery J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-29 Liangliang Niu, Yan Luo, Huan Xu, Haili Huang, Rui Jiang, Xinghuai Sun
This study aimed to evaluate the clinical correlative factors and outcomes of treatment of bleb-associated endophthalmitis (BAE) following glaucoma filtration surgery in a Chinese population from the year 2012 to 2022, and to compare them with the clinical course during the coronavirus disease (COVID-19) pandemic period. This was a retrospective analysis of consecutive cases of BAE treated at the Eye
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Immune recovery uveitis in Whipple’s disease: an unusual ocular presentation J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-13 Hippolyte Lequain, Stéphane Abramowicz, Julien Seiller, Amro Abukhashbah, Carole Burillon, Emmanuelle Vignot, Olivier Brunet, Pascal Sève
To describe an unusual case of Whipple’s disease (WD) complicated by uveitis, and subsequent paradoxical worsening after effective antibiotic treatment targeting Tropheryma whipplei (TW). Case report. A 53-year-old male presented with bilateral knee arthritis, weight loss, chronic low-grade fever, and cognitive disorders. He was under treatment with tumor necrosis factor α inhibitors (TNFi) for seronegative
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Triple Gram-negative bacterial endophthalmitis following intravitreal injection J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-09 Samy Zaher, Hector Rodriguez-Villalobos
To describe a puzzling case of endophthalmitis caused by three unusual bacteria after intravitreal injection, its outcome, and underlying questions. A 70-year-old female patient was diagnosed with acute endophthalmitis following intravitreal aflibercept injection for age-related macular degeneration. A standard tap and inject procedure was performed. Microbiological analyses on the anterior chamber
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Diagnosis of primary vitreoretinal lymphoma masquerading infectious retinitis by retinal biopsy J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-07 Nam V. Nguyen, Farid Khan, Andrew Cannon, Ye Huang, Lucas Kim, Rena Xu, Pukhraj Rishi, Christopher D. Conrady, Timothy C. Greiner, Ana Yuil-Valdes, Steven Yeh
To report a case of primary vitreoretinal lymphoma masquerading as infectious retinitis that was diagnosed via a retinal biopsy. A 72-year-old female patient was referred to our ophthalmology clinic for evaluation of retinitis and vasculitis in the right eye (OD). On examination, best-corrected visual acuities (BCVAs) were hand motions OD and 20/20 in the left eye (OS). Fundus examination revealed
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Risk factors for failing sub-Tenon’s triamcinolone acetonide for uveitic macular edema J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-01 Amit K. Reddy, Jennifer L. Patnaik, Alan G. Palestine
Sub-Tenon’s triamcinolone acetonide (STA) is less effective than intravitreal corticosteroids in the treatment of uveitic macular edema (ME), but does have some relative advantages, including substantially lower cost and decreased risk of post-injection ocular hypertension. It would be useful for clinicians to know which eyes may respond well to STA and not necessarily require intravitreal therapy
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Long-term follow-up of a healthy man with endogenous Streptococcus anginosus endophthalmitis J. Ophthal. Inflamm. Infect. Pub Date : 2024-02-01 Juan Martin Sanchez, Mauricio Davila, Michael Halpert, Radgonde Amer
We report the long-term follow-up of an immunocompetent patient who presented with slowly progressive endogenous endophthalmitis secondary to Streptococcus anginosus. A 46-year-old healthy man presented with a two-month history of right eye iritis. On examination, visual acuity was 20/60 with intraocular pressure of 6 mm Hg. There was a small layer of hypopyon with non-granulomatous anterior uveitis
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In vivo confocal microscopy evaluation of infiltrated immune cells in corneal stroma treated with cell therapy in advanced keratoconus J. Ophthal. Inflamm. Infect. Pub Date : 2024-01-26 Mona El Zarif, Karim Abdul Jawad, Jorge L. Alió, Nehman Makdissy, María P. De Miguel
This study investigates immune cell (ICs) infiltration in advanced keratoconus patients undergoing autologous adipose-derived adult stem cell (ADASC) therapy with recellularized human donor corneal laminas (CL). A prospective clinical trial included fourteen patients divided into three groups: G-1, ADASCs; G-2, decellularized CL (dCL); and G-3, dCL recellularized with ADASCs (ADASCs-rCL). Infiltrated
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The role of lymphatic vessels in corneal fluid homeostasis and wound healing J. Ophthal. Inflamm. Infect. Pub Date : 2024-01-22 Karina Hadrian, Claus Cursiefen
The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this privilege, allowing blood and lymphatic vessels to invade, potentially impairing vision and causing immune responses. This review explores the complex role of corneal lymphangiogenesis in health and diseases. Traditionally, the cornea was considered devoid of lymphatic
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Restoring vision after cat bite: a case report on successful diagnostic and therapeutic regimen for Capnocytophaga endophthalmitis J. Ophthal. Inflamm. Infect. Pub Date : 2024-01-22 Lasse Wolfram, David A. Merle, Jonas Neubauer, Spyridon Dimopoulos
Capnocytophaga is a bacterium frequently found in the oral flora of dogs and cats (e.g. Capnocytophaga canimorsus) and humans (e.g. Capnocytophaga gingivalis). Among Capnocytophaga related ocular infections, fulminant endophthalmitis is a rare but sight-threatening clinical manifestation. A 35-year-old previously healthy patient presented after a cat bite into the left upper and lower eyelid and nasal
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Long-term follow-up of a bilateral acute posterior multifocal placoid pigment epitheliopathy following COVID-19 infection: a case report J. Ophthal. Inflamm. Infect. Pub Date : 2024-01-04 Casper Lund-Andersen, Oliver Niels Klefter, Miklos Schneider
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory eye disorder that is characterized by the presence of multiple placoid lesions in the posterior pole of the eye. Relentless placoid chorioretinitis (RPC) is an inflammatory chorioretinopathy that combines clinical features of APMPPE and serpiginous chorioretinitis, which is a progressive condition with a high
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Three cases of recalcitrant Paecilomyces keratitis in Southern California within a short period J. Ophthal. Inflamm. Infect. Pub Date : 2024-01-04 Christine K. Kim, Joseph T. Mekhail, David M. Morcos, Christopher D. Yang, Sanjay R. Kedhar, Cinthia Kim, Maria Del Valle Estopinal, Olivia L. Lee
The aim of this report is to describe the risk factors, clinical course, and characteristics of three cases of Paecilomyces keratitis presenting concurrently within three months in the same location. We used in vivo confocal microscopy and histopathology to corroborate our clinical findings. Three eyes of three elderly patients with culture-proven Paecilomyces keratitis were included in this series
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Corneal ring infiltrate- far more than Acanthamoeba keratitis: review of pathophysiology, morphology, differential diagnosis and management J. Ophthal. Inflamm. Infect. Pub Date : 2023-12-19 J. Przybek-Skrzypecka, J. Skrzypecki, L. Suh, J. P. Szaflik
Ring infiltrates usually accompany numerous infectious and sterile ocular disorders. Nevertheless, systemic conditions, drugs toxicity and contact lens wear may present with corneal ring infiltrate in substantial part. Considering its detrimental effect on vision, detailed knowledge on etiology, pathophysiology, differential diagnosis, and management should be considered essential for every ophthalmologist
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Tuberculosis reactivation demonstrated by choroiditis and inflammatory choroidal neovascular membrane in a patient treated with immune checkpoint inhibitors for malignant mucosal melanoma J. Ophthal. Inflamm. Infect. Pub Date : 2023-12-18 Melissa L. Murphy, Duncan Rogers
To describe a complex case of ocular tuberculosis reactivation with anterior uveitis, choroiditis and inflammatory choroidal neovascular membrane (CNVM) following immune checkpoint inhibitor (ICPI) treatment of malignant mucosal melanoma. A retrospective collection of medical history, clinical findings and multimodal imaging with literature review of the topic was conducted. A 52-year-old Romanian
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Surgical induced necrotizing scleritis following intraocular lens replacement J. Ophthal. Inflamm. Infect. Pub Date : 2023-12-07 Pablo González de los Mártires, Gonzalo Guerrero Pérez, Iñigo Les Bujanda, Iñaki Elejalde Guerra, Henar Heras Mulero, Esther Compains Silva
To report a surgical-induced necrotizing scleritis, as well as its medical and surgical management. Case-report. An 88 year-old patient with a three-day severe single-left-eye ocular pain. One-time surgery involving PPV with removal of dislocated intraocular lens and secondary implantation of iris-claw Artisan® lens was performed 6 months earlier. Visual acuity of 20/100. Slit-lamp examination revealed
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Resuming anti-TNF therapy after development of miliary tuberculosis in Behcet’s disease-related uveitis: a case report J. Ophthal. Inflamm. Infect. Pub Date : 2023-11-28 Chika Toriu, Kinya Tsubota, Yoshihiko Usui, Hiroshi Goto
There is no consensus concerning restarting anti-tumour necrosis factor (TNF)-α therapy for uveitis after treatment for active tuberculosis (TB). We report a case of Behcet disease (BD) in which treatment with TNF inhibitor was successfully resumed after treatment for miliary TB. A 48-year-old Japanese male was treated for uveitis of unknown aetiology in the left eye at a general ophthalmology clinic
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Gains in the current understanding of managing neovascular AMD with brolucizumab J. Ophthal. Inflamm. Infect. Pub Date : 2023-11-23 Bahram Bodaghi, Arshad M. Khanani, Ramin Khoramnia, Carlos Pavesio, Quan Dong Nguyen
Unresolved retinal fluid and high injection burden are major challenges for patients with neovascular age-related macular degeneration. Brolucizumab addresses these challenges by providing robust vision gains and superior fluid resolution, with the potential for longer treatment intervals. Brolucizumab has been associated with adverse events of retinal vasculitis and retinal vascular occlusion typically
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Ocular inflammatory events and COVID-19 vaccination: correspondence J. Ophthal. Inflamm. Infect. Pub Date : 2023-11-08 Pathum Sookaromdee, Viroj Wiwanitkit
Dear Editor, we read the article entitle “Ocular inflammatory events following COVID-19 vaccination: a multinational case series [1]” with a great interest. Testi et al. concluded that “Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were
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False negative result of polymerase chain reaction in very early stages of acute retinal necrosis J. Ophthal. Inflamm. Infect. Pub Date : 2023-11-08 Haibo Wang, Zhuyun Qian, Lin Cui, Beichen Liu, Jixin Zou, Lu Wang, Yong Tao, Lijun Zhang, Lei Jin
Viral nucleic acid testing of intraocular fluid using polymerase chain reaction (PCR) is a major laboratory examination in the diagnosis of acute retinal necrosis (ARN). Importantly, false negative PCR results may occur in several special situations. We reported a case of ARN with a negative PCR result in the aqueous humour in the very early stages of disease. A female patient presented to the ophthalmologist
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Endophthalmitis caused by Burkholderia cepacia complex (BCC): clinical characteristics, antibiotic susceptibilities, and treatment outcomes J. Ophthal. Inflamm. Infect. Pub Date : 2023-11-03 Flavius A. Beca, Jesse D. Sengillo, Hailey K. Robles-Holmes, Prashanth G. Iyer, Darlene Miller, Nicolas A. Yannuzzi, Harry W. Flynn
To report the clinical characteristics, antibiotic susceptibilities, and review the literature of Burkholderia cepacia complex (BCC) associated endophthalmitis. Retrospective, observational case series. Clinical and microbiology records were reviewed for patients evaluated at the Bascom Palmer Eye Institute and diagnosed wisth culture-confirmed endophthalmitis due to BCC. Antibiotic susceptibility
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Investigating the effect of eye drops based on iodine nanoparticles in the treatment of corneal ulcers in rabbit eyes J. Ophthal. Inflamm. Infect. Pub Date : 2023-10-26 Mostafa Feghi, Sharif Makhmalzadeh, Nasrin Masihpour, Mansour Amin, Nader Mortazavinia
Various organisms, such as bacteria, viruses, and fungi, can cause corneal ulcers. One of the leading causes of vision loss and disability worldwide is corneal ulceration. Practical, accessible, and affordable treatment for this disease seems essential. Fifteen New Zealand rabbits infected with Staphylococcus aureus (ATCC 25923) corneal ulcers were randomly divided into three groups of five for the
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Stenotrophomonas maltophilia endophthalmitis following keratoplasty J. Ophthal. Inflamm. Infect. Pub Date : 2023-10-13 Bilge Tarım, Mücella Arıkan Yorgun, Birsen Özdem, Emine Kalkan Akçay
Endophthalmitis is among the most sight-threatening infections in ophthalmology practice. Many microorganisms causing endophthalmitis have been reported. Stenotrophomonas maltophilia is among the rare causes of endophthalmitis and has been reported after cataract surgery, intravitreal injections and ocular trauma. We report a case of S. maltophilia endophthalmitis after keratoplasty, which is a rare
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Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-27 Anitha Manoharan, Harshita Atmakur, Parthopratim Dutta Majumder, Jyotirmay Biswas
A 47-year-old woman with hypertension and rheumatoid arthritis presented with non-necrotizing scleritis in both eyes. Despite a course of oral corticosteroids, she continued to experience persistent symptoms. A rheumatologist was consulted and initiated treatment with tofacitinib, a JAK/STAT inhibitor. Treatment with tofacitinib and oral corticosteroids resulted in an improvement in the scleritis in
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Ocular manifestations following COVID-19 vaccination J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-23 Padmamalini Mahendradas, Sai Bhakti Mishra, Rohini Sangoram, Sanjay Srinivasan, Ankush Kawali, Aditya Patil, Rohit Shetty
Immunologic and inflammatory adverse effects following vaccination against COVID-19 are being reported. While some reactions may develop denovo others concern its immunogenic effect in patients with pre-existing inflammatory conditions. Retrospective consecutive patients diagnosed with ocular inflammatory manifestations within 8 weeks of receiving COVID-19 vaccination who presented to a tertiary eye
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Idiopathic sclerosing dacryoadenitis J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-19 Samantha D. Butterfield, Rona Z. Silkiss
Dacryoadenitis is an inflammation of the lacrimal gland. This condition has an extensive differential diagnosis, requiring a thorough workup to identify the underlying etiology. If no etiology is identified, the condition is termed idiopathic dacryoadenitis. The purpose of this report is to present a case of idiopathic sclerosing dacryoadenitis and review the diagnostic process. We present a case of
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Efficacy of intravitreal dexamethasone implant used as monotherapy for the treatment of macular edema in non-infectious uveitis: a retrospective analysis J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-18 Rishi B. Gupta, Julius Ilin, Chloe C. Gottlieb
Uveitic macular edema is a complication of acute or chronic uveitis. Current treatment regiments frequently have numerous side effects, often requiring supplemental treatment. This study investigates the efficacy of dexamethasone (DEX) intravitreal implants as monotherapy for treatment of macular edema in non-infectious intermediate, posterior or panuveitis. Retrospective chart review of thirty patients
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Ocular sarcoidosis in adults and children: update on clinical manifestation and diagnosis J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-18 Magdalena Bazewicz, Jarmila Heissigerova, Carlos Pavesio, François Willermain, Janusz Skrzypecki
Sarcoidosis-associated uveitis, is the predominant ocular sarcoidosis presentation, which affects both adults and children. For adults, international ocular sarcoidosis criteria (IWOS) and sarcoidosis-associated uveitis criteria (SUN) are defined. However, for children they are not yet established internationally. Due to the specificity of pediatric manifestations of sarcoidosis, this task is even
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Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-16 Carolin Elhardt, Armin Wolf, Christian Maximilian Wertheimer
This case report describes the course and therapeutic management of a fast-spreading bacterial keratitis caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa). A 27-year-old male contact lens wearer presented with a multi-resistant, fast spreading P. aeruginosa keratitis. After initial resistance to various antibiotic therapies, testing revealed a MDR P. aeruginosa. The keratitis
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Recurrent superior orbital fissure syndrome associated with VEXAS syndrome J. Ophthal. Inflamm. Infect. Pub Date : 2023-09-07 Katie Myint, Namritha Patrao, Oana Vonica, Kaveh Vahdani
To describe a case of recurrent orbital inflammation and superior orbital fissure syndrome associated with VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome. VEXAS syndrome is a recently identified multi-system inflammatory disease of late adult onset. The authors describe the case of a 76-year-old man who presented with recurrent episodes of orbital inflammation, with superior
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Clinical characterization of patients with HLA-B27-associated uveitis and evaluation of the impact of systemic treatment on the recurrence rate: a cross-sectional study J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-30 Juan Sebastián Pineda-Sierra, Carlos Cifuentes-González, William Rojas-Carabali, Paula Tatiana Muñoz-Vargas, Alejandro Henao-Posada, Alejandra de-la-Torre
Despite HLA-B27-associated uveitis is one of the most frequent etiologies of uveitis worldwide, there are scarce studies on the clinical spectrum of this disease and the implications of therapeutic strategies used in the Latin-American population, with none conducted in Colombia. Thus, this study aimed to describe the clinical characteristics of a cohort of patients with positive HLA-B27-associated
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Targeting macrophage migration inhibitory factor (MIF): a promising therapy for inflammatory ocular diseases J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-25 Alicia Vázquez, Marisol I. González, José L. Reyes
Inflammatory ocular diseases are characterized by the presence of a persistent inflammatory response which cause tissue injury, decrease visual acuity and in severe cases, blindness. Several cytokines represent a therapeutic opportunity since they are key amplifiers of these pathologies, and thus neutralizing agents against them have been developed. Amongst others, macrophage migration inhibitory factor
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Lightning can strike twice: recurrent multiple evanescent white dot syndrome (MEWDS) following both COVID-19 vaccination and subsequent COVID-19 infection J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-24 Hannah W. Ng, Rachael L. Niederer
Multiple evanescent white dot syndrome has been reported to occur following COVID-19 vaccination and also secondary to COVID-19 infection. Increasingly, patients are querying their risk from further vaccination against COVID-19, vaccination for other diseases (such as influenza) and the risk of disease with COVID-19 infection itself. Here we report an interesting case in which the patient developed
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Challenges in posterior uveitis—tips and tricks for the retina specialist J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-17 Manuel Paez-Escamilla, Sonny Caplash, Gagan Kalra, Jamie Odden, Danielle Price, Oscar C. Marroquin, Stephen Koscumb, Patrick Commiskey, Chad Indermill, Jerome Finkelstein, Anna G. Gushchin, Andreea Coca, Thomas R. Friberg, Andrew W. Eller, Denise S. Gallagher, Jean C. Harwick, Evan L. Waxman, Jay Chhablani, Gabrielle Bonhomme, Colin Prensky, Alexander J. Anetakis, Joseph N. Martel, Erika Massicotte
Posterior uveitis is a common chorioretinal pathology affecting all ages worldwide and is a frequent reason for referral to the retina clinic. The spectrum of etiologies for uveitis is very broad and includes infectious and auto-immune diseases. Inflammation can be confined to the eye or may be a part of systemic disease. A useful outline is therefore proposed to aid in the correct diagnosis of these
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Cytomegalovirus anterior uveitis and occlusive retinal vasculitis without retinitis in a patient on immunomodulatory therapy J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-04 Lorenzo Fabozzi, Ilaria Testi, Laura De Benito-Llopis, Carlos Pavesio
To describe unusual clinical features and therapeutic management of a case of cytomegalovirus (CMV) ocular disease in a patient on immunomodulatory therapy. Moorfields Eye Hospital NHS Foundation Trust, London, UK. Medical history, clinical findings, investigation results, and multimodal imaging were retrospectively collected. A 61-year-old, South-East Asian man, developed CMV-related endotheliitis
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Peripheral retinal cysts in presumed ocular toxocariasis J. Ophthal. Inflamm. Infect. Pub Date : 2023-08-02 Rym Maamouri, Aida Jallouli, Olfa Béizig, Monia Cheour
Typical clinical manifestations of ocular toxocariasis are central posterior granuloma, peripheral granuloma and chronic endophthalmitis. Herein we report the presence of peripheral subretinal cysts in two cases with a presumed ocular toxocariasis (OT).
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Efficacious switching from subcutaneous to intravenous tocilizumab in patients with non-infectious non-anterior uveitis J. Ophthal. Inflamm. Infect. Pub Date : 2023-07-18 Mathilde Leclercq, Paul Goupillou, Hélène Gomez, Marc Muraine, Ygal Benhamou, Nicolas Girszyn, Julie Gueudry
The efficacy of tocilizumab in refractory chronic noninfectious uveitis has been previously reported, but no data comparing intravenous and subcutaneous tocilizumab in uveitis are available. We report a case series of patients with chronic noninfectious uveitis with incomplete efficacy of subcutaneous tocilizumab, improved after switching to intravenous routes. Improvement of visual acuity was observed
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Varicella zoster virus-associated non-necrotizing retinitis: case report J. Ophthal. Inflamm. Infect. Pub Date : 2023-07-06 Maamouri Rym, Houman Yasmine, Abdelaziz Marwa, Helal Imen, Cheour Monia
To describe clinical features and the course of a case of non-necrotizing herpetic retinitis secondary to Varicella zoster virus (VZV). A single case report documented with multimodal imaging. A 52-year-old female patient with a past medical history of diabetes mellitus who presented with painful red right eye (OD). Ophthalmic examination showed perilimbal conjunctival nodule, granulomatous anterior
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Acute macular neuroretinopathy following Moderna COVID-19 vaccination J. Ophthal. Inflamm. Infect. Pub Date : 2023-06-29 Olena Protsyk, Roberto Gallego-Pinazo, Rosa Dolz-Marco
To describe the occurrence of an acute macular neuroretinopathy (AMN) after administration of a Moderna COVID-19 Vaccine. Case report. A 23-year-old female presented bilateral visual loss one week after the first dose of COVID-19 vaccine. Fundus examination revealed the classic wedge-shaped lesions with petaloid configuration around both foveas. Hypo-reflective macular lesions are evident in the near-infrared
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Risk of failing both methotrexate and mycophenolate mofetil from the First-line Antimetabolites as Steroid-sparing Treatment (FAST) uveitis trial J. Ophthal. Inflamm. Infect. Pub Date : 2023-06-09 Amit K. Reddy, D. Claire Miller, Amol A. Sura, SR Rathinam, John A Gonzales, Radhika Thundikandy, Anuradha Kanakath, Bala Murugan, Rajesh Vedhanayaki, Lyndell L. Lim, Eric B. Suhler, Thuy Doan, Hassan A. Al-Dhibi, Debra A. Goldstein, Lourdes Arellanes-Garcia, Nisha R Acharya
The antimetabolites methotrexate (MTX) and mycophenolate mofetil (MMF) are commonly used as initial corticosteroid-sparing treatment for uveitis. There is little data examining risk factors for failing both MTX and MMF. The objective of this study is to determine risk factors for failing both MTX and MMF in patients with non-infectious uveitis. This is a sub-analysis of the First-line Antimetabolites
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Combined central retinal vein occlusion and cilioretinal artery occlusion as the initial presentation of frosted branch angiitis: a case report and literature review J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-25 Abdullah Albahlal, Waleed Khayyat, Sulaiman M. Alsulaiman
To report a case of combined central retinal vein occlusion (CRVO) with cilioretinal artery occlusion (CLRAO) that heralded the development of frosted branch angiitis (FBA). A 25-year-old healthy male presented with sudden painless visual loss in his left eye with a visual acuity (VA) of 20/300. Fundus exam and fluorescein angiography showed signs of combined CRVO and CLRAO. Without treatment, his
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Immunosuppressive therapy for Vogt-Koyanagi-Harada disease: a retrospective study and review of literature J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-19 Najiha Rahman, Jose Carlo M Artiaga, Konstantinos Bouras, Joshua Luis, Angela Rees, Mark Westcott
Vogt-Koyanagi-Harada (VKH) disease is an idiopathic autoimmune disease which targets melanin-containing tissues such as the uvea, meninges, ear and skin. This typically presents in the eye with acute findings of granulomatous anterior uveitis, diffuse choroidal thickening, multiple focal areas of sub-retinal fluid and, in severe cases, optic nerve involvement with bullous serous retinal detachment
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Uveitis including Vogt-Koyanagi-Harada syndrome following inactive covid-19 vaccination: a case series J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-19 Mehrdad Motamed Shariati, Mojtaba Abrishami, Shahin Jahani, Ali Bolouki, Mohamad-Reza Ansari-Astaneh, Seyedeh Maryam Hosseini
Currently, large populations have been vaccinated against COVID-19. The whole inactivated Sinopharm COVID-19 vaccine has been the main available COVID-19 vaccine in Iran. Ocular inflammatory reactions have been reported following vaccination. The present case reports aim to introduce four cases of uveitis after the Sinopharm vaccine administration. Our first reported case is a 38-year-old woman with
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An atypical presentation of sympathetic ophthalmia following chemical ocular burns J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-16 Pooja Bansal, Maninder Singh, Yashi Gupta, Nikhil Gotmare, Meenakshi Thakar, Ritu Arora
Sympathetic ophthalmia is a rare disease that can present as bilateral granulomatous uveitis after a penetrating trauma or surgery in one eye. We report a case of a 47-year-old male with history of decreased vision in the right eye, six months after sustaining severe chemical injury in the left eye. He was diagnosed with sympathetic ophthalmia and was treated with corticosteroids and long-term immunosuppressive
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Atypical presentation of bilateral Epstein-Barr virus dacryoadenitis: a case report of corticosteroid resistant orbital inflammation J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-12 Charissa H. Tan, Pamela S. Tauchi-Nishi, Adam R. Sweeney
Epstein-Barr virus is a known cause of dacryoadenitis that is typically sensitive to corticosteroid treatment. When affecting the orbit, particularly the lacrimal gland, Epstein-Barr virus may cause chronic proptosis and a bilateral lacrimal mass effect. We provide a case of bilateral Epstein-Barr virus associated dacryoadenitis initially resistant to corticosteroid treatment requiring biopsy and confirmation
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The role of the calcofluor white staining in the diagnosis of Acanthamoeba keratitis J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-02 Carolin Elhardt, Romina Schweikert, Lennart Maximilian Hartmann, Efstathios Vounotrypidis, Adnan Kilani, Armin Wolf, Christian Maximilian Wertheimer
Acanthamoeba keratitis is often misdiagnosed at disease onset. This study presents data to confirm the diagnosis using calcofluor white (CFW) staining. Forty three patients were retrospectively included who presented to the Department of Ophthalmology at the University Hospital Ulm with keratitis between 2000 and 2022. Condition positive cases were diagnosed based on the typical clinical presentation
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Correction: Recurrent post-operative endophthalmitis caused by Sphingomonas paucimobilis despite vitrectomy – a case and review of the literature J. Ophthal. Inflamm. Infect. Pub Date : 2023-05-01 Luke Tran, Rylan Hayes, Andrew Apel, Thomas P Moloney
Correction: Journal of Ophthalmic Inflammation and Infection 13, 7 (2023) https://doi.org/10.1186/s12348-023-00325-6 Following publication of the original article [1], it came to the authors' attention that the name of the author Andrew Apel had been erroneously given as 'Andrew Apel Franzco'. The published article has since been corrected and the corrected author list may be seen in this erratum.
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Human retinal endothelial cells express functional interleukin-6 receptor J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-25 Lisia Barros Ferreira, Liam M. Ashander, Binoy Appukuttan, Yuefang Ma, Keryn A. Williams, Giles Best, Justine R. Smith
Interleukin (IL)-6 is an inflammatory cytokine present in the eye during non-infectious uveitis, where it contributes to the progression of inflammation. There are two major IL-6 signaling pathways: classic signaling and trans-signaling. Classic signaling requires cellular expression of the IL-6 receptor (IL-6R), which exists in membrane-bound (mIL-6R) and soluble (sIL-6R) forms. Prevailing dogma is
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Incidence and clinical characteristic of ocular surface manifestation: an evaluation of conjunctival swab results in Corona Virus 2019 (COVID-19) patients in Jakarta, Indonesia J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-25 Made Susiyanti, Hisar Daniel, Diah Faridah, Dinda Arken Devona, Pradnya Pramitha, Budiman Bela, Budi Haryanto, Julie Dewi Barliana, Dian Estu, Andi Arus Victor, Nina Dwi Putri, Julius Candra, Nathania Sutandi, Rita S. Sitorus
This study aimed to investigate the spectrum of ocular characteristics and viral presence in the conjunctival swab of patients with COVID-19. In this cross-sectional study, fifty-three patients were recruited from two COVID-19 referral hospitals in Jakarta (Cipto Mangunkusumo Hospital and Persahabatan Hospital) from July 2020 to March 2021. The inclusion criteria were patients who were suspected of
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MRSA panophthalmitis in a brittle diabetic J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-17 Erin Flynn, Stephen Lesche, Sabita Ittoop, Tamer Mansour, Stephanie Barak, Keith James Wroblewski
Endophthalmitis is defined as infection of the inner coats or substance of the eye. This condition is caused through exogenous or endogenous sources that act as a nidus for infection. Exogenous cases of endophthalmitis typically occur from ocular trauma or as a postoperative complication. Endogenous causes of endophthalmitis are much less common, comprising only 5–10% of endophthalmitis cases [1].
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Epidemiological profile of microbial keratitis in Alexandria-Egypt a 5 years retrospective study J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-13 Suzan Ibrahim Sakr, Amira Ahmed Nayel, Christeena Saeed Habeel, Hala Kamal Elkhabiry, Ghada Mahmoud Ibrahim, Mona Mohamed Tolba, Alaa Atef Ghaith
To evaluate the epidemiologic profile of microbial keratitis in Alexandria- Egypt, with special emphasis on risk factors, visual outcome and microbiological results. This retrospective study reviewed files of patients treated for microbial keratitis during a period of 5 years at Alexandria Ophthalmology Hospital Cornea Clinic, Alexandria- Egypt, between February 2017 and June 2022. The patients were
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Ocular side effects of Trametinib and Dabrafenib: a case report J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-12 Bilge Tarım, Meltem Kılıç
A 53-year-old man who has stage 4 non-small cell lung carcinoma and treated with Dabrafenib-Trametinib combination chemotherapy; presented with decreased bilateral visual acuity. We checked out slit lamp examination, fundoscopy, optical coherence tomography and fundus fluorescein angiography. In slit lamp biomicroscopy; bilateral posterior synechiae, granulomatous keratic precipitates and + 4 cells
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Relation between ocular paraneoplastic syndromes and Immune Checkpoint Inhibitors (ICI): review of literature J. Ophthal. Inflamm. Infect. Pub Date : 2023-04-06 Pauline Casselman, Julie Jacob, Pieter-Paul Schauwvlieghe
To describe different ocular paraneoplastic syndromes in patients treated with Immune Checkpoint Inhibitors (ICI), its relation with different types of ICI and different types of tumors, and its implications for treatment. A comprehensive review of the literature was performed. Patients treated with ICI can present with different ocular paraneoplastic syndromes, such as Carcinoma Associated Retinopathy
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Do not discount the diagnosis of VKH based on race: self-reported race and ethnicity of patients with Vogt-Koyanagi-Harada disease in a predominantly white population J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-29 Gábor Gy. Deák, Anjum F. Koreishi, Debra A. Goldstein
We examined the racial and ethnic distribution of patients with Vogt-Koyanagi-Harada disease (VKH) in a Midwestern US population through a retrospective chart review of patients with VKH seen in a tertiary referral centre between 2012 and 2017. All patients were diagnosed by one uveitis specialist (DAG). We identified 32 patients with VKH seen during this time period. The mean age at diagnosis was
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Central retinal vein occlusion associated with Bartonella henselae infection J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-28 Sunil Bellur, Amir Ali, Nam V. Nguyen, Joshua K. Fernandes, Shilpa Kodati
To report the clinical features and treatment course of a case of central retinal vein occlusion (CRVO) as the initial sign of ocular Bartonella henselae (B. henselae) infection. A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) was 20/400 in the left eye. Clinical examination revealed
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Bilateral exudative retinal detachment, unusual pattern of uveitis with multiple sclerosis J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-22 Rehab Sabry Helal, Saket Arya, Rami Abu Sbeit, Maha Elshafei
MS (Multiple sclerosis) associated uveitis used to have limited phenotypes. Bilateral exudative retinal detachment has never been recognized as a pattern of MS-associated uveitis. We are reporting a patient with multiple sclerosis who presented initially with the usual pattern of intermediate uveitis and later developed bilateral exudative retinal detachment.
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Unusual pattern of herpetic optic neuropathy: a case report and literature review of the pathophysiology of herpetic uveitis J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-21 Rehab Sabry Helal, Rami Abu Sbeit, Zamzam Mohammed Al-Baker
Herpetic uveitis is a relatively common type of intraocular inflammation with a broad spectrum of manifestations ranging from mild anterior uveitis to rapidly progressing vision threatening necrotizing retinitis. Posterior herpetic uveitis presents with different clinical patterns within a spectrum depending presumably on the immune status of the patient. Systemic steroid use for viral uveitis without
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Granulomatous panuveitis in disseminated sporotrichosis: case report and review of the literature J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-09 Wijak Kongwattananon, Tanavadee Rattanaphong
To report a case of intraocular sporotrichosis presenting with bilateral granulomatous panuveitis. Observational case report and literature review. A 62-year-old woman with a history of polycythemia vera presented with a non-healing ulcer at the left index finger, generalized erythematous papules, and bilateral granulomatous panuveitis. Cultures of skin and amputated finger identified Sporothrix schenckii
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Some practical issues about HLA-A29 in birdshot retinochoroiditis J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-09 Ioannis Papasavvas, Jonas J. W. Kuiper, Carl P. Herbort Jr
To the editor HLA-A29 birdshot retinochoroiditis (BRC) is a bilateral posterior uveitis which affects simultaneously, although independently, the retina and the choroid. The retinal presentation is marked by vasculitis, involving both small and large vessels, papillitis and macular oedema while choroidal involvement takes the form of a primary stromal choroiditis, with active, often occult, foci occupying
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En-face widefield optical coherence tomography angiography for understanding vascular networks changes in two cases of acute retinal necrosis J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-07 Mami Tomita, Mizuki Tagami, Norihiko Misawa, Atsushi Sakai, Yusuke Haruna, Shigeru Honda
The present study assesses the utility of en-face widefield optical coherence tomography angiography (OCTA) imaging for evaluating the retinal vascular network during the course of treatment in acute retinal necrosis(ARN). OCTA images of two cases of acute retinal necrosis were analyzed. Case 1 was a 15-year-old male with visual crowding in his right eye who had best-corrected visual acuity of 16/20
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Recurrent post-operative endophthalmitis caused by Sphingomonas paucimobilis despite vitrectomy – a case and review of the literature J. Ophthal. Inflamm. Infect. Pub Date : 2023-03-06 Luke Tran, Rylan Hayes, Andrew Apel Franzco, Thomas P Moloney
Over the past 20 years, scattered reports have emerged about a low virulence, gram negative bacillus, Sphingomonas paucimobilis, causing unpredictable clinical presentations of endophthalmitis. Previous reports have characterised the organism as being resistant to aggressive treatment and prone to recurrence up to several months later, with few warning signs of any residual infection. We report a case