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Efficacy and Predictive Factors of Oral Spironolactone Treatment in Chronic Central Serous Chorioretinopathy J. Ophthalmol. (IF 1.9) Pub Date : 2024-3-18 Sheng Gao, Yun Zhang, Meixia Zhang
Purpose. To evaluate the efficacy of spironolactone in the treatment of chronic central serous chorioretinopathy (CSC) and identify imaging characteristics that can predict the benefit of spironolactone treatment. Methods. Patients with chronic CSC were treated with spironolactone (20 mg/tid) and followed for 6 months. The primary outcome measure was complete resolution of the subretinal fluid (SRF)
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Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects J. Ophthalmol. (IF 1.9) Pub Date : 2024-3-11 Andrew Tirsi, Vasiliki Gliagias, Daniel Zhu, Benny Wong, Rohun Gupta, Sung Chul Park, Stephen Obstbaum, Celso Tello
Purpose. The purpose of this study was to investigate the utility of steady state pattern electroretinogram (ss-PERG) in detecting retinal ganglion cell (RGC) dysfunction in glaucoma suspects (GS) who had normal 24-2 Humphrey Visual Fields (HFA). Materials and Methods. This was a prospective cohort study of GS patients who were identified based on optic disc appearance with normal HFAs. Patients received
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Microsurgical Vitrectomy with Pars Plana Incision for the Removal of Posterior Segment Intraocular Foreign Bodies J. Ophthalmol. (IF 1.9) Pub Date : 2024-3-9 Xin Liu, Meng Meng Ji, Ling Jin, Ai Ping Zeng
This study describes a pars plana incision surgical technique combined with 23 or 25-gauge vitrectomy in the management of intraocular foreign bodies (IOFBs) and to assess its anatomical and functional results. Sixteen patients with ocular trauma complicated with IOFB were enrolled in our study. The mean preoperative visual acuity was 2.01 ± 0.55 LogMAR, and the mean postoperative visual acuity at
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Mutational Profile and Retinal Phenotypes of PCARE-Related Cone-Rod Dystrophies in a Mexican Cohort J. Ophthalmol. (IF 1.9) Pub Date : 2024-3-4 Víctor R. López-Rodríguez, Rocío Arce-González, Alan Martínez-Aguilar, Carlos E. Rodríguez-López, Sergio Groman-Lupa, M. Isabel Neria-González, Genaro Rodríguez-Uribe, Juan C. Zenteno
Purpose. The aim of the study is to describe the genotype and phenotype of a Mexican cohort with PCARE-related retinal disease. Methods. The study included 14 patients from 11 unrelated pedigrees with retinal dystrophies who were demonstrated to carry biallelic pathogenic variants in PCARE. Visual assessment methods included best corrected visual acuity, color fundus photography, Goldmann visual field
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Advanced Periocular Basal Cell Carcinoma with Orbital Invasion: Update on Management and Treatment Advances J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-29 Alvaro Bengoa-González, Enrique Mencía-Gutiérrez, María Garrido, Elena Salvador, María-Dolores Lago-Llinás
Purpose. Basal cell carcinoma (BCC) is the most frequent malignant periocular tumor. It is associated with exposure to ultraviolet radiation, and its incidence is gradually increasing. It may occasionally display more aggressive behavior and result in orbital or intracranial invasion. Mortality from periocular BBC with orbital invasion is very low, but the associated morbidity can be significant, from
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Association between Axial Length to Corneal Curvature Radius Ratio and Myopia in Adult Patients J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-28 Yanyun Fan, Yikeng Huang, Xionggao Huang
Purpose. To analyze the distribution characteristics of axial length to corneal curvature radius ratio (AL/CR) and other ocular biometric parameters in adult myopia patients and their association with myopia. Methods. A cross-sectional study was conducted among patients with no eye diseases except ametropia who attended the optometry clinic of the First Affiliated Hospital of Hainan Medical College
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Longitudinal Rates of Change in Structural Parameters of Optical Coherence Tomography in Primary Angle Closure Glaucoma following Laser Iridotomy along with Peripheral Iridoplasty J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-27 Hyun-Kyung Cho, Changwon Kee
Background. This study aimed to investigate longitudinal rates of change (LRCs) of structural parameters from optical coherence tomography (OCT) in patients with primary angle closure glaucoma (PACG) after laser iridotomy (LI) along with laser peripheral iridoplasty (PI). Methods. Among 146 patients diagnosed with PACG, thirty-two subjects (32 eyes) who underwent LI plus PI and accomplished more than
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Transcanthal Canthopexy for Involutional Lower Eyelid Entropion Corrects Horizontal Laxity J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-13 Shinjiro Kono, Motohiro Kamei
In this prospective observational study, we aimed to examine improvements in horizontal laxity after lower eyelid retractor advancement and transcanthal canthopexy for involutional lower eyelid entropion. The study included 19 sides in 15 patients with involutional entropion who underwent transcanthal canthopexy with the advancement of the lower eyelid retractor. Using the pinch test, the distance
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Clinical and Imaging Characteristics of Metastatic Orbital Tumours in North China J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-10 Yun Zhao, Shasha Yu, Mengxia Mu, Jiagen Li, Hongxun Li, Hong Zhao
Purpose. This study was designed to review the primary sites, clinical manifestations, imaging features, treatments, and outcomes of 36 patients with orbital metastasis in North China. Methods. This was a retrospective review of 36 patients with orbital metastasis at Tianjin Eye Hospital between January 2010 and December 2020 in North China as well as a review of the literature. Results. Thirty-six
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Efficacy of 2% Hydroxypropyl Methylcellulose and Bandage Contact Lens for the Management of Dry Eye Disease after Cataract Surgery J. Ophthalmol. (IF 1.9) Pub Date : 2024-2-1 Tianyao Zhao, Xiaodan Jiang, Ran Hao, Yi Ding, Dalan Jing, Xuemin Li
Objectives. To investigate the effect of 2% hydroxypropyl methylcellulose (HPMC) and bandage contact lens (BCL) on dry eye disease after cataract surgery. Methods. This prospective randomized controlled trial included 63 eyes which were divided into the balanced salt solution (BSS), HPMC, BCL, and combined HPMC and BCL (H&B) groups. The Ocular Surface Disease Index (OSDI), tear meniscus height (TMH)
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The Effect of a Loading Dose Regimen in the Switch to Brolucizumab for Patients with Aflibercept-Resistant nAMD J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-30 Hiroyuki Kamao, Erika Mitsui, Yuto Date, Katsutoshi Goto, Kenichi Mizukawa, Atsushi Miki
Purpose. To evaluate the one-year outcomes of switching to brolucizumab with and without a loading dose regimen (three monthly injections) in eyes with aflibercept-resistant neovascular age-related macular degeneration (nAMD). Methods. We retrospectively studied nAMD patients who had retinal exudate under bimonthly injections of aflibercept and were switched to brolucizumab from aflibercept. Patients
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Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-30 Alessia Guarnera, Paola Valente, Luca Pasquini, Giulia Moltoni, Francesco Randisi, Chiara Carducci, Alessia Carboni, Giulia Lucignani, Antonio Napolitano, Antonino Romanzo, Daniela Longo, Carlo Gandolfo, Maria Camilla Rossi-Espagnet
Congenital malformations of the eye represent a wide and heterogeneous spectrum of abnormalities that may be part of a complex syndrome or be isolated. Ocular malformation severity depends on the timing of the causative event during eye formation, ranging from the complete absence of the eye if injury occurs during the first weeks of gestation, to subtle abnormalities if the cause occurs later on.
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Long-Term Surgical Outcomes of Glaucoma Drainage Implants in Eyes with Preoperative Intraocular Pressure Less than 19 mmHg J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-24 Shahin Hallaj, Jae-Chiang Wong, Lauren E. Hock, Natasha Nayak Kolomeyer, Aakriti G. Shukla, Michael J. Pro, Marlene R. Moster, Jonathan S. Myers, Reza Razeghinejad, Daniel Lee
Background. This retrospective review reports on patients who underwent glaucoma drainage implant (GDI) surgery and had baseline intraocular pressure (IOP) of ≤18 mmHg with at least one year of follow-up. Methods. Clinical data of 67 eyes of 67 patients were collected from patients’ charts, and the outcomes of GDI were evaluated until 7 years. GDI failure was defined as IOP reduction of less than 20%
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Long-Term Visual Quality and Pupil Changes after Small-Incision Lenticule Extraction for Eyes without Preoperative Cylinder Refraction J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-20 Xiaonan Yang, Qiting Feng, Quan Liu, Jianhui Chen, Pengxia Wan
Purpose. To investigate the long-term changes in visual quality and pupil size after small incision lenticule extraction (SMILE) for eyes without preoperative cylinder refraction. Methods. Thirty-three myopic eyes (33 patients) without preoperative cylinder refraction were corrected using SMILE. Refractive outcomes, corneal curvature, aberrations, contrast sensitivity (CS), and pupil diameter were
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miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-19 Jie Bian, Weizhong Ge, Zhengmei Jiang
Purpose. Diabetic retinopathy (DR) is an ocular disease caused by diabetes and may lead to vision impairment and even blindness. Oxidative stress and inflammation are two key pathogenic factors of DR. Recently, regulatory roles of different microRNAs (miRNAs) in DR have been widely verified. miR-26a-5p has been confirmed to be a potential biomarker of DR. Nevertheless, the specific functions of miR-26a-5p
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Accommodation and Binocular Vision in Children with Myopic Anisometropia J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-16 Chu-chu Zhuang, Ling Zhang, Shan-shan Pan, Yi-ning Wang, Jian-xin Guo
Purpose. To assess the differences in accommodation and binocular vision in children with myopic anisometropia and determine the correlation with anisometropia. Method. A total of 110 patients with myopia aged 8–15 years were recruited from June 2021 to February 2022 from the Affiliated Hospital of Xuzhou Medical University. Based on the interocular differences of spherical equivalent refraction, patients
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Changes in Corneal Higher-Order Aberrations and Ocular Biometric Measurements after Phacoemulsification Combined with Goniosynechialysis in Primary Angle Closure/Glaucoma Patients J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-12 Jiali Xia, Siqi Guo, Fei Hu, Liqi Fan, Ling Yu, Jian Ye
Purpose. To compare corneal higher-order aberrations (HOAs), refractive error, and ocular biological parameters before and after phacoemulsification combined with goniosynechialysis (Phaco-GSL) in primary angle closure/glaucoma (PAC/PACG) patients with different axial lengths (ALs). Methods. In this prospective study, cataract patients diagnosed with PAC/PACG were categorized into two groups based
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The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-2 Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou
Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patient’s genes, age, gender, cardiovascular disease, unhealthy diet, and living habits may also be risk factors
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Corneal Epithelial Thickness Mapping: A Major Review J. Ophthalmol. (IF 1.9) Pub Date : 2024-1-2 Mohammad-Ali Abtahi, Amir Hushang Beheshtnejad, Golshan Latifi, Marjan Akbari-Kamrani, Sadegh Ghafarian, Ahmad Masoomi, Seyed Ali Sonbolastan, Hamidreaza Jahanbani-Ardakani, Mehrnaz Atighechian, Laleh Banan, Hosein Nouri, Seyed-Hossein Abtahi
The corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling.
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Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells J. Ophthalmol. (IF 1.9) Pub Date : 2023-12-30 Ayaka Nakai, Deokho Lee, Chiho Shoda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Toshihide Kurihara
Background. Anti-vascular endothelial growth factor (anti-VEGF) therapy via intravitreal injection is an effective treatment for patients with abnormal ocular neovascularization, such as age-related macular degeneration (AMD) and diabetic macular edema (DME). However, prolonged and frequent anti-VEGF treatment is associated with a risk of local and systemic adverse events, including geographic atrophy
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Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review J. Ophthalmol. (IF 1.9) Pub Date : 2023-11-22 Masoud Rahimi, Esmaeil Asadi Khameneh, Hamid Riazi-Esfahani, Tahereh Mahmoudi, Elias Khalili Pour, Rahele Kafieh
Background. This study aimed to review the literature on the application of ImageJ in optical coherence tomography angiography (OCT-A) images. Methods. A general search was performed in PubMed, Google Scholar, and Scopus databases. The authors evaluated each of the selected articles in order to assess the implementation of ImageJ in OCT-A images. Results. ImageJ can aid in reducing artifacts, enhancing
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Gender- and Age-Related Differences of Ocular Biometric Parameters in Patients Undergoing Cataract Surgery in Bosnia and Herzegovina J. Ophthalmol. (IF 1.9) Pub Date : 2023-11-21 Edita Zvorničanin, Zoran Vatavuk, Maja Popović, Jasmin Zvorničanin
Purpose. The aim of the study is to determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender- and age-related differences in patients undergoing cataract surgery in Bosnia and Herzegovina. Materials and Methods. It was a retrospective cross-sectional study of consecutive patients who underwent cataract surgery between January 2017 and December
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A Prospective Study of Clinical Features of Anterior Uveitis in Taiwan J. Ophthalmol. (IF 1.9) Pub Date : 2023-11-7 Wei-Yu Chiang, Shih-Chou Chen, Shwu-Jiuan Sheu, Hsi-Kung Kuo
In this study, we reported the patterns, epidemiology, and clinical features of anterior uveitis (AU) in Taiwan, an area of Eastern Asia. This prospective, cross-sectional case series study was performed to identify patients with AU at two tertiary medical centers (Kaohsiung Chang Gung Memorial Hospital and Kaohsiung Veterans General Hospital) located at the southern Taiwan between December 1, 2018
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Postintravitreal Injection Endophthalmitis: Incidence, Characteristics, Management, and Outcome J. Ophthalmol. (IF 1.9) Pub Date : 2023-11-6 Bar Davidov, Avi Ohayon, Omer Trivizki, Shulamit Schwartz, Shiri Shulman
Purpose. Postintravitreal injection (IVI) endophthalmitis is a rare but devastating complication. Herein, we report the incidence ,and clinical and microbiological characteristics, as well as the visual outcome, in IVIs endophthalmitis in two medical centers. Methods. All patients undergoing intravitreal injections between 1/2018 and 12/2019 in two large medical centers were analyzed for post-IVI endophthalmitis
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A Cross-Sectional Study of Myopia and Morning Melatonin Status in Northern Irish Adolescent Children J. Ophthalmol. (IF 1.9) Pub Date : 2023-11-1 Jane M. Fulton, Sarah C. Flanagan, Julie J. Sittlington, Diego Cobice, Sara Dobbin, Sara J. McCullough, Gareth Orr, Patrick Richardson, Kathryn J. Saunders
Purpose. Previous studies have demonstrated an association between melatonin status and both refractive error and axial length in young adult myopes. This study aimed to determine if this relationship extends to a younger adolescent cohort. Methods. Healthy children aged 12–15 years provided morning saliva samples before attending Ulster University (55°N) for cycloplegic autorefraction and axial length
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Evaluation of Fundus Function in Mature Cataract Patients by Visual Electrophysiology J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-31 Min Zhang, Min Ji, Mengjia Tan, Ying Yu, Huaijin Guan
Purpose. To explore the value of visual electrophysiology in evaluating the fundus function of mature cataract patients. Methods. 124 mature cataract patients (153 eyes) were examined before cataract surgery; the examinations included best corrected visual acuity (BCVA), pattern visual evoked potential (PVEP), full-field electroretinogram (ffERG), and multifocal electroretinogram (mfERG). According
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Glaucoma Characteristics and Influencing Factors during the COVID-19 Pandemic in the Huizhou Region J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-26 Huilan Zhou, Rui Liao, Dongxuan Zhang, Wei Wang, Shuifeng Deng
Objective. Glaucoma in individuals who tested positive for the coronavirus disease 2019 (COVID-19) during the pandemic outbreak has not been comprehensively studied. Therefore, this study aimed to analyze the characteristics and risk factors of glaucoma during the COVID-19 pandemic in Huizhou. Methods. Retrospective data from outpatients with glaucoma at the Huizhou Hospital Affiliated with Guangzhou
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Inhaled Corticosteroid Exposure and Risk of Cataract in Patients with Asthma and COPD: A Systematic Review and Meta-Analysis J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-19 Osman Savran, Charlotte Suppli Ulrik
Purpose. Both systemic and inhaled corticosteroids may increase the risk of cataract in patients with both chronic obstructive pulmonary disease (COPD) and asthma. Our aim was to assess the degree of association between cataract and corticosteroid exposure in patients with asthma and COPD. Methods. A systematic literature review and meta-analysis was performed according to the Preferred Reporting Items
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Changes in Stress-Strain Index in School-Aged Children: A 3-Year Longitudinal Study J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-14 Zhengfei Yang, Bo Wu, Zhouyue Li, Mengting Yu, Jinyun Jiang, Shuyuan Chen, Shengsong Xu, Junwen Zeng, Mengyi Wang, Xiao Yang
Purpose. To determine three-year change of the corneal biomechanical parameter stress-strain index (SSI) in schoolchildren aged 7– 9 years and their correlation with refractive error and axial length (AL). Methods. This is a prospective cohort study. Data of the AL, refractive error, and corneal biomechanical parameter SSI were collected at baseline and a 3-year follow-up for 217 schoolchildren. SSI
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Optical Coherence Tomography Angiography for Evaluation of Conjunctival Vessels in Dry Eyes J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-14 TongFeng Cui, HongYan Sun, ZiZhong Hu, YaBo Shi, Jiang Zhu, ManMan Jin, Bing Qin
Objective. This study aimed to evaluate conjunctival vessels in patients with dry eye disease (DED) using optical coherence tomography angiography (OCTA). Methods. This was a cross-sectional, observational clinical study. Twenty-three eyes of 18 patients with DED and 28 eyes of 23 healthy controls were included for examination in this study. The evaluation included the application of an Ocular Surface
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Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus J. Ophthalmol. (IF 1.9) Pub Date : 2023-10-6 Abdelrahman Salman, Cosimo Mazzotta, Obeda Kailani, Marwan Ghabra, Rana Omran, Ashraf Armia Balamoun, Taym Darwish, Rafea Shaaban, Hala Alhaji
Aim. To establish the diagnostic accuracy of corneal and epithelial thickness measurements obtained by spectral-domain optical coherence tomography (SD-OCT) in detecting keratoconus (KC) and suspect keratoconus (SKC). Methods. This retrospective study reviewed the data of 144 eyes separated into three groups by the Sirius automated corneal classification software: normal (N) (n = 65), SKC (n = 43)
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Etiological Factors and Visual Outcomes of Dense Vitreous Hemorrhage in Patients Aged 80 years and above over the Past Decade in a Tertiary General Hospital J. Ophthalmol. (IF 1.9) Pub Date : 2023-9-28 Yuhua Ding, Bangtao Yao, Hui Ye, Fei Wang
This study aimed to investigate the main etiological factors and visual outcomes in patients with dense vitreous hemorrhage (DVH) aged ≥80 years. We retrospectively included patients with DVH aged ≥80 years who were admitted to our ophthalmology department between January 1, 2010, and December 31, 2019. All patients underwent pars plana vitrectomy (PPV). Data regarding demographic characteristics;
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The Quality of Life of Seniors with Eye Diseases during COVID-19 J. Ophthalmol. (IF 1.9) Pub Date : 2023-9-26 Brian Edward Yu, Shehzad Ali, Hyunsoo Jang, Samantha So, Michael Huang, Cindy Hutnik, Monali Malvankar-Mehta
Purpose. To assess health-related quality of life (HRQoL), vision-related quality of life (VRQoL), depression and anxiety symptoms, and social support and community integration of seniors with eye diseases and to identify important predictor variables of the outcomes. Methods. A cross-sectional survey was performed in seniors with eye diseases (n = 90). Demographic characteristics and questionnaire
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The Relationship between Axis Length Difference and Refractive Error in Unilateral Myopic Anisometropic Children Treated with Orthokeratology J. Ophthalmol. (IF 1.9) Pub Date : 2023-9-4 Lu Sun, Zheng-Xuan Li, Shi-Peng Wang, Hong-Xin Song
Purpose. To explore the correlation between the axial length (AL) difference (myopic and nonmyopic eye) and the refractive error in children with unilateral myopia anisometropia (UMA) and to elucidate its clinical application in the process of Ortho-K lenses review following nonstop wearing. Methods. This study retrospectively analyzed the data of 70 children with UMA (age, 8–15 years) whose myopic
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Biomedical Data Annotation: An OCT Imaging Case Study J. Ophthalmol. (IF 1.9) Pub Date : 2023-8-22 Matthew Anderson, Salman Sadiq, Muzammil Nahaboo Solim, Hannah Barker, David H. Steel, Maged Habib, Boguslaw Obara
In ophthalmology, optical coherence tomography (OCT) is a widely used imaging modality, allowing visualisation of the structures of the eye with objective and quantitative cross-sectional three-dimensional (3D) volumetric scans. Due to the quantity of data generated from OCT scans and the time taken for an ophthalmologist to inspect for various disease pathology features, automated image analysis in
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Comparison of Weight-Gain-Based Prediction Models for Retinopathy of Prematurity in an Australian Population J. Ophthalmol. (IF 1.9) Pub Date : 2023-8-17 Alexander Bremner, Li Yen Chan, Courtney Jones, Shaheen P. Shah
Purpose. Four weight-gain-based algorithms are compared for the prediction of type 1 ROP in an Australian cohort: the weight, insulin-like growth factor, neonatal retinopathy of prematurity (WINROP) algorithm, the Children’s Hospital of Philadelphia Retinopathy of Prematurity (CHOPROP), the Colorado Retinopathy of Prematurity (CO-ROP) algorithm, and the postnatal growth, retinopathy of prematurity
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Efficacy of Topical Azithromycin versus Systemic Doxycycline in Treatment of Meibomian Gland Dysfunction J. Ophthalmol. (IF 1.9) Pub Date : 2023-8-8 Marwa Aly Zaky, Adel Galal Zaky, Moataz Fayez Elsawy, Kareem Fatehy Shehata, Mohamed Samy Abd Elaziz
Background. Ocular surface disease (OSD) is a multifactorial and highly frequent problem. Inadequate or unstable tear film is the main cause, which leads to visual impairments. One of the primary causes of OSD is meibomian gland dysfunction (MGD), with a prevalence of 3.5 to 70%. The aim of this work was to compare the efficacy of azithromycin topical eye drops versus oral doxycycline in MGD individuals
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Pattern of Uveitis in a Tertiary Hospital in North Jordan and the Impact of Behcet’s Disease J. Ophthalmol. (IF 1.9) Pub Date : 2023-8-8 Khaldoon M. Alawneh, Omar A. Saleh, Mahmoud M. Smadi, Fatima Kamel Ababneh, Ikhlas Hamed Ali Mahmoud, Areje M. Smadi, Diala Alawneh
Aim. The purpose of this study is to assess the prevalence of autoimmune-mediated uveitis in relation to other diseases and to describe the clinical patterns of uveitis in a single tertiary hospital in north Jordan. Methods. A cross-sectional retrospective review was performed. We included all patients diagnosed with uveitis in King Abdullah University Hospital (KAUH) ophthalmology clinic and/or patients
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Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities J. Ophthalmol. (IF 1.9) Pub Date : 2023-7-22 Ran Zhang, Bo Li, Heng Li
The extracellular matrix (ECM) is a noncellular structure that plays an indispensable role in a series of cell life activities. Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the occurrence and development of miscellaneous diseases. Nevertheless, the role of ECM stiffness in ophthalmology
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Inverted Pedicled Internal Limiting Membrane Flap Attached to an Optic Disc with Autologous Blood Clot for Large Macular Holes J. Ophthalmol. (IF 1.9) Pub Date : 2023-7-14 Lishuai Zhang, Huiyu Xi, Jiayu Chen, Aiqin Sheng, Wei Fan, Suyan Li, Haiyang Liu
Purpose. An inverted ILM flap might be accidentally separated from the retina or sucked away during surgery for large macular holes (MHs). This article is to determine the efficacy of a new inverted pedicled internal limiting membrane (ILM) flap attached to an optic disc with an autologous blood clot (ABC) technique for the treatment of large MHs. Methods. An inverted pedicled ILM flap connected to
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Rehabilitation Methods for Patients with Geographic Atrophy due to Age-Related Macular Degeneration and Effects of Rehabilitation on Quality of Life J. Ophthalmol. (IF 1.9) Pub Date : 2023-7-8 Damla Erginturk Acar, Figen Batioglu, Aysun Idil, Esra Sahli, Dincer Goksuluk
Purpose. The purpose of the study is to evaluate the low vision rehabilitation methods and to investigate the effect of visual rehabilitation on quality of life in patients with low vision due to geographic atrophy from age-related macular degeneration (ARMD). Methods. The better-seeing eye of 78 patients with geographic atrophy due to ARMD were included in the study. Sociodemographic characteristics
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Influence of Pilocarpine Eyedrops on the Ocular Biometric Parameters and Intraocular Lens Power Calculation J. Ophthalmol. (IF 1.9) Pub Date : 2023-7-7 Ruxin Gao, Jinkun Liu, Xiaojie Zhou, Luping Huang, Weiyi Huang, Yingying Xue, Fei Wang, Songjian Gong, Renyi Wu, Yuhong Wang
Objective. To evaluate the influence of pilocarpine eyedrops on the ocular biometric parameters and whether these parameter changes affect the intraocular lens (IOL) power calculation in patients with primary angle-closure glaucoma (PACG). Methods. Twenty-two PACG patients and fifteen normal subjects were enrolled. Ocular biometric parameters including the axial length (AL), anterior chamber depth
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Corneal Astigmatism Alteration after Combined Silicone Oil Removal and Cataract Surgery with Intraocular Lens Implantation J. Ophthalmol. (IF 1.9) Pub Date : 2023-6-28 Zhenyu Ji, Ting Su, Lu Li, Tao He, Yu Su
Purpose. To explore short-term changes in corneal astigmatism after combined silicone oil removal and cataract (SORC) surgery. Methods. We enrolled 89 patients (43 men and 46 women). Zeiss IOLMaster was used to measure corneal astigmatism status and axial length on the day before and after the SORC surgery. Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were recorded. The results
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The Impact of Angle Lambda on Patient Satisfaction after Optiflex Trio Trifocal Intraocular Lens Implantation J. Ophthalmol. (IF 1.9) Pub Date : 2023-6-17 Sultan Kaya Ünsal, Ertan Sunay
Purpose. To evaluate the vision-related quality of life (QOL), visual acuities, and refractive outcomes of patients with different angle lambda (λ) after a trifocal intraocular lens (IOL) implantation at Veni Vidi Eye Hospital, İstanbul, Turkey. Methods. This retrospective, nonrandomized, and noncomparative case series included patients who had phacoemulsification bilaterally with the implantation
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Clinical Outcomes with Extended Depth of Focus Intraocular Lenses in Cases in Which Multifocal Lenses Are Not Primarily Recommended J. Ophthalmol. (IF 1.9) Pub Date : 2023-6-16 María Teresa Álvarez-García, Carlota Fuente-García, Cristina Muñoz-Puyol, David P. Piñero
Purpose. The purpose of the study is to evaluate the visual and patient-reported outcomes of patients undergoing cataract surgery with implantation of an extended depth of focus (EDOF) intraocular lens (IOL) who were not primarily good candidates for multifocal IOL implantation. Methods. Retrospective analysis of data from 30 eyes (23 patients) undergoing cataract surgery with implantation of one of
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Optical Coherence Tomography Angiography Characteristics of Polypoidal Lesions in Caucasians J. Ophthalmol. (IF 1.9) Pub Date : 2023-6-13 Daniel Ahmed-Balestra, Alexandra Graf, Martin Stattin, Anna-Maria Haas, Stefan Kickinger, Michael Jacob, Claus Zehetner, Katharina Krepler, Siamak Ansari-Shahrezaei
Purpose. The aim of the study is to analyze the swept source-optical coherence tomography angiography (SS-OCTA) characteristics of polypoidal lesions in Caucasian patients. Methods. In this retrospective observational case series, 43 polypoidal lesions in 32 eyes of 32 patients were diagnosed using indocyanine green angiography (ICGA) and compared to SS-OCTA at a tertiary medical retina center (Clinic
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A Novel Role for Corneal Pachymetry in Planning Cataract Surgery by Determining Changes in Spherical Equivalent Resulting from a Previous LASIK Treatment J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-31 Arthur Hammer, Tjebo F. C. Heeren, Romesh Angunawela, John Marshall, Kamran Saha
Objectives. To provide a metric to differentiate between hyperopic and myopic ablation of a prior LASIK treatment based on the corneal pachymetry profile after laser vision correction (LVC). Methods. Pachymetry data were retrospectively recovered from patients who had previous LASIK for refractive purposes between 2019 and 2020. Patients with any corneal disorder were excluded. Ablation spherical equivalent
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The Influence of Accommodation on Retinal Peripheral Refraction Changes in Different Measurement Areas J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-22 Weicong Lu, Zisu Peng, Wenzhi Ding, Rongyuan Ji, Yuyin Tian, Chenpei Zhao, Lin Leng
Background. The change in refraction caused by accommodation inevitably affects the peripheral defocus state and thus may influence the effect of retinal peripheral myopic defocus measures in myopia control. This study investigated accommodation changes in different peripheral retinas under cycloplegia to help improve myopia control. Methods. Fifty-six eyes of fifty-six myopic subjects were recruited
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The 100 Most Frequently Cited Articles on Myopia J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-11 Rachel Shemesh, Sarah Dichter, Eedy Mezer, Tamara Wygnanski-Jaffe
Purpose. To provide a bibliographical-historical perspective and main interest in the field of myopia. Methods. In this bibliographic study, the Web of Science Database was searched from 1999 to 2018. Recorded parameters included journal name, impact factor, year and language, number of authors, type and origin, methodology, number of subjects, funding, and topics. Results. Epidemiological assessments
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SubFoveal Choroidal Imaging in High Myopic Nepalese Cohort J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-11 Parash Gyawali, Ashutosh Jnawali, Anish Kharal, Manish Subedi, Sandeep Kandel, Prajjol Raj Puri, Nabin Paudel
Purpose. Evidence suggests that choroid is thinner in myopes as compared to nonmyopes. However, choroidal thickness varies with the refractive error, age, axial length, and ethnicity. The purpose of this study was to determine the subfoveal choroidal thickness (SFCT) in high myopic Nepalese subjects and to investigate its association with the mean spherical equivalent refractive error (MSE), axial
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Effects of Cycloplegic Agents on Ocular Parameters in Children with Myopia and Hyperopia J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-11 Guangzhi Qu, Bingfeng Wang, Saisai Ding, Xiaocui Liu, Lei Gao, Xuli Wang
Background. To study the effect of cycloplegia on ocular parameters in children with myopia and hyperopia. Methods. Forty-two myopia and forty-four hyperopia eyes in children between 5 and 10 years of age were included. Measurements were taken before and after cycloplegia using 1% atropine sulfate ointment. The ocular parameters included central corneal thickness (CCT), corneal curvature (CC), anterior
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Long-Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-10 Shamil Patel, George Reiss
Purpose. To investigate the clinical effectiveness of canaloplasty performed with an ab interno technique using the iTrack microcatheter (Nova Eye Medical) in patients with mild-moderate glaucoma as compared to severe glaucoma. Methods. This is a retrospective single-center case series. Patients were preoperatively categorized as mild/moderate vs. severe glaucoma assessed using the mean deviation (MD)
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Visual Performance of Eyes with Residual Refractive Errors after Implantation of an Extended Vision Intraocular Lens J. Ophthalmol. (IF 1.9) Pub Date : 2023-5-4 Laureano A. Rementería-Capelo, Inés Contreras, Aida Morán, Pilar Lorente-Hevia, Laura Mariñas, Javier Ruiz-Alcocer
Background. To analyze the tolerance on distance vision of different combined residual astigmatic situations in patients implanted with a novel wavefront shaping extended depth of focus (EDoF) intraocular lens (IOL). Methods. The study included patients implanted with the Acrysof® IQ Vivity® IOL. Uncorrected (UDVA) and corrected distance visual acuity (CDVA) were measured three months after surgery
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BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-28 Xin Cao, Tao Li, Yongshen Tian, Yajing Tian, Chuang Gao, Dongmei Zhang, Yu Song
Diabetic retinopathy (DR) is one of the microvascular complications of diabetes mellitus and a major pathological feature of neovascular DR. These patients potentially experience vision impairment and blindness. Platelet-derived growth factor receptor β (PDGFRβ), fibroblast growth factor receptor 1 (FGFR1), and vascular endothelial growth factor receptor 2 (VEGFR2) are implicated in the DR pathogenesis
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Investigating the Clinical Characteristics and PITX3Mutations of a Large Chinese Family with Anterior Segment Mesenchymal Dysgenesis and Congenital Posterior Polar Cataract J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-24 Hui Dang, Min Peng, Weiyue Gu, Gang Ding, Yuqin Sun, Zhongkai Hao, Ning Wei, Xu Wang, Chenming Zhang, Aijun Deng
Objective. To investigate the clinical characteristics and pathogenic genetic mutations of a Chinese family with anterior segment mesenchymal dysgenesis and congenital posterior polar cataract. Methods. Through family investigation, the family members were examined via slit lamp anterior segment imaging and screened for eye and other diseases by eye B-ultrasound. Genetic test was performed on the blood
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Assessment of Silicone Oil Emulsification: A Comparison of Currently Applied Methods J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-24 Hongmei Zhao, Qian Chen, Jian Yu, Kaicheng Wu, Yuan Zong, Chunhui Jiang, Haohao Zhu, Gezhi Xu
Purpose. To compare ultrasound biomicroscopy (UBM), Coulter counter, and B-scan ultrasonography in the evaluation of silicone oil (SO) emulsification. Methods. Patients who underwent primary pars plana vitrectomy with SO tamponade for rhegmatogenous retinal detachment and SO removal were included. UBM images were acquired before the SO removal, and B-scan images were taken after removal. The number
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Flapless and Conjunctiva-Sparing Technique for Transscleral Fixation of Intraocular Lens to Correct Refractive Errors in Eyes without Adequate Capsular Support J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-19 Wei Lou, Ziang Chen, Yang Huang, Haiying Jin
Purpose. To evaluate refractive outcomes, intraocular lens (IOL) power calculation, and IOL position following a novel conjunctiva-sparing transscleral fixation technique. Methods. Forty-one eyes of 40 patients managed with a flapless transscleral-sutured technique were included. Preoperative and postoperative refractive errors (spherical equivalents, SE) were compared. IOL position was assessed on
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Meta-Analysis of Phacoemulsification and Laser Peripheral Iridotomy in the Treatment of Primary Angle-Closure Glaucoma J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-19 Jia Xie, Pengcheng Li, Bo Han
Background. In this meta-analysis, we aimed to systematically compare the efficacy and safety of phacoemulsification and laser peripheral iridotomy (LPI) in the treatment of primary angle-closure glaucoma (PACG). Method. We searched PubMed, MEDLINE, EMBASE, the Cochrane Library, the Chinese Journal Full-text Database (CNKI), the Wanfang database, and the China Science and Technology Journal Database
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Changes of Peripapillary Capillary Density in Patients with Vogt–Koyanagi–Harada Disease Evaluated by Optical Coherence Tomography Angiography J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-17 Zhijian Jiang, Huiying Ji, Nan Zhang, Liang Huang, Min Zhou, Jianhong Dong
Objective. To analyze the longitudinal changes in peripapillary capillary density in patients with acute VKH with or without optic disc swelling by optical coherence tomography angiography (OCTA). Methods. Retrospective case series. 44 patients (88 eyes) were enrolled and were divided into two groups according to presence/absence of optic disc swelling before treatment. Peripapillary capillary images
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Efficacy and Safety of an Ophthalmic DMPC-Based Nanoemulsion in Patients with Dry Eye Disease: A Phase I/II Randomized Clinical Trial J. Ophthalmol. (IF 1.9) Pub Date : 2023-4-10 Leopoldo M. Baiza-Durán, Patricia Muñoz-Villegas, Alejandra Sánchez-Ríos, Oscar Olvera-Montaño
Purpose. The goals of this study were to evaluate the safety and efficacy of an ophthalmic 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-based nanoemulsion (Nanodrop®) in patients with dry eye disease (DED). Methods. This was a randomized phase I/II multicentric, prospective, double-blind clinical trial. Patients (phase I: n = 25 and phase II: n = 101) were assigned to receive either PRO-176 (Nanodrop®)