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Implementation of value-based healthcare in ophthalmology: a scoping review BMJ Open Ophthalmol. Pub Date : 2024-03-01 Zulkarnain Abubakar, Amal Chalik Sjaaf, Tjahjono Darminto Gondhowiardjo, Moh Anfasa Giffari Makkaraka
Objective This review aimed to identify and summarise how value-based healthcare (VBHC) is implemented in the field of ophthalmology. Methods A scoping review was conducted by searching empirical and non-empirical articles from from electronic databases (PubMed, Science Direct, ProQuest and Scopus) and other methods starting January 2006 (the year Porter and Teisberg introduced VBHC) up to 31 December
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Method comparison and overview of refractive measurements in children: implications for myopia management BMJ Open Ophthalmol. Pub Date : 2024-03-01 Jonas Müller, Xiaoqin Chen, Arne Ohlendorf, Lihua Li, Siegfried Wahl
Objective This study investigated the agreement between objective wavefront-based refraction and subjective refraction in myopic children. It also assessed the impact of cyclopentolate and refraction levels on the agreement. Methods A total of 84 eyes of myopic children aged 6–13 years were included in the analysis. Non-cycloplegic and cycloplegic objective wavefront-based refraction were determined
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Association of sildenafil use with age-related macular degeneration: a retrospective cohort study BMJ Open Ophthalmol. Pub Date : 2024-03-01 Ji Eun Diana Han, Anuradhaa Subramanian, Wen Hwa Lee, Jesse Coker, Alastair K Denniston, Krishnarajah Nirantharakumar, Nicola Jaime Adderley
Objective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD
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Saffron therapy for the ongoing treatment of age-related macular degeneration BMJ Open Ophthalmol. Pub Date : 2024-03-01 Geoffrey K Broadhead, John Grigg, Peter J McCluskey, Thomas Hong, Timothy E Schlub, Eugenia Chu, Andrew A Chang
Objective To assess the long-term efficacy and safety of oral saffron, a natural antioxidant, in treating mild/moderate age-related macular degeneration (AMD). Methods and analysis Open-label, extension trial of 93 adults (>50 years) with mild/moderate AMD and vision >20/70 Snellen equivalent in at least 1 eye. Exclusion criteria included confounding visual lesions or significant gastrointestinal disease
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Peripapillary retinal nerve fibre layer thinning, perfusion changes and optic neuropathy in carriers of Leber hereditary optic neuropathy-associated mitochondrial variants BMJ Open Ophthalmol. Pub Date : 2024-03-01 Clare Quigley, Kirk A J Stephenson, Paul F Kenna, Lorraine Cassidy
Background We investigated Leber hereditary optic neuropathy (LHON) families for variation in peripapillary retinal nerve fibre layer thickness and perfusion, and associated optic nerve dysfunction. Method A group of LHON-affected patients (n=12) and their asymptomatic maternal relatives (n=16) underwent examination including visual acuity (VA), visual-evoked-potential and optic nerve imaging including
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Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration BMJ Open Ophthalmol. Pub Date : 2024-03-01 Raymond Matthew Bellis, Yang Fei, Brandon Le, Gerardo Ledesma-Gil, Oscar Otero-Marquez, Yuehong Tong, Katy Tai, Richard B Rosen, Gareth M C Lema, Roland Theodore Smith
Purpose Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage. Methods Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51–100; 61% women). Spectral-domain
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Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment BMJ Open Ophthalmol. Pub Date : 2024-03-01 Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Christof Meigen, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy, Adrienne Csutak
Objective To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters on treatment outcomes. Methods and analysis This retrospective observational study included 62 individuals aged 4–17 years (mean±SD: 10.21±2.70) with
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Research productivity and gender of research award recipients in international ophthalmology societies BMJ Open Ophthalmol. Pub Date : 2024-02-01 Anne Xuan-Lan Nguyen, Dipti Satvi Venkatesh, Ankita Biyani, Sanyam Ratan, Gun Min Youn, Albert Y Wu
Purpose The purpose of this study is to assess the research productivity and gender of award recipients of ophthalmology research awards in international societies. Methods This is a retrospective, observational study. The study population included award recipients of research awards from 36 ophthalmologic societies (listed on the International Council of Ophthalmology database) in 99 years (1922–2021)
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Assessment of performance and safety of Corneal Chamber hypothermic storage medium and PSS-L corneal rinsing solution in human and porcine corneas BMJ Open Ophthalmol. Pub Date : 2024-02-01 Laura Giurgola, Umberto Rodella, Claudio Gatto, Orietta Rossi, Claudia Honisch, Eugenio Ragazzi, Paolo Ruzza, Stefano Ferrari, Jana D'Amato Tóthová
Purpose To prove the safety and performance of the hypothermic corneal storage medium "Corneal Chamber" and the rinsing solution "PSS-L" in support of the new Conformité Européenne (CE) certification process in accordance with the Medical Device Regulation. Methods Fifteen (n=15) human donor corneas and 11 (n=11) porcine corneas were evaluated for the following parameters: endothelial cell density
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Needs and views on eye health and women’s empowerment and theory of change map: implication on the development of a women-targeted eyecare programme for older Zanzibari craftswomen BMJ Open Ophthalmol. Pub Date : 2024-02-01 Fatma Omar, Kayleigh McCluskey, Eden Mashayo, Ai Chee Yong, Damaris Mulewa, Christine Graham, Carlos Price-Sanchez, Omar Othman, Ronnie Graham, Ving Fai Chan
Objectives To assess needs and views regarding eye health and empowerment from craftswomen’s perspectives to develop a theory of change (ToC) for a women-targeted eyecare programme. Material and methods Eighteen stakeholders participated in a 2-day consultation workshop in Zanzibar. The composition was (1) 15 women and 3 men; (2) Unguja (n=8), Pemba (n=6) and Tanzania mainland (n=4) and (3) craftswomen
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Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population BMJ Open Ophthalmol. Pub Date : 2024-02-01 Alexander Tanner, Mandeep S Sagoo, Omar A Mahroo, Jose S Pulido
Background Large genomic databases enable genetic evaluation in terms of haploinsufficiency and prevalence of missense and synonymous variants. We explored these parameters in ocular tumour-associated genes. Methods A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans
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Paediatric norms for photopic electroretinogram testing based on a large cohort of Chinese preschool children BMJ Open Ophthalmol. Pub Date : 2024-02-01 Sonia Seen-hang Chan, Kai Yip Choi, Henry Ho-lung Chan
Objective Full-field electroretinogram (ffERG) is an objective test to determine the electroretinal activities in response to light stimulation for investigating retinal physiology and diagnosing retinal diseases. This study aimed to establish a reference data set of photopic electroretinogram (ERG) of Chinese preschool children in Hong Kong to facilitate clinical and research studies. Methods and
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Relation between a history of glaucoma and subjective happiness: the JPHC-Next study BMJ Open Ophthalmol. Pub Date : 2024-02-01 Ryutaro Yamanishi, Erisa Yotsukura, Akiko Hanyuda, Miki Uchino, Kenya Yuki, Kazuno Negishi, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Kiyoshi Aoyagi, Kozo Tanno, Kazumasa Yamagishi, Isao Muraki, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada
Objective This population-based, cross-sectional study was performed to investigate the relationship between a history of glaucoma and subjective happiness. Methods and analysis We conducted a cross-sectional questionnaire-based survey of 92 397 Japanese men and women aged 40–74 who participated in the Japan Public Health Center-based Prospective Study for the Next Generation study. A multivariable
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Rates of visual field change and functional progression in glaucoma following trabecular microbypass implantation of iStent technologies: a meta-analysis BMJ Open Ophthalmol. Pub Date : 2024-02-01 Kevin Gillmann, Dana M Hornbeak
Background/aim While intraocular pressure (IOP) remains the only modifiable risk factor for glaucoma progression, the ultimate goal of glaucoma management is to preserve patients’ functional vision and quality of life. To this end, minimally invasive glaucoma surgeries (MIGSs) aim to reduce IOP with minimal eye trauma. Commonly used MIGS devices include iStent technologies, which have well-documented
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Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review BMJ Open Ophthalmol. Pub Date : 2024-02-01 Nikolaos Dervenis, Panagiotis Dervenis, Eleftherios Agorogiannis
Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic
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Associations between dry eye disease and sleep quality: a cross-sectional analysis BMJ Open Ophthalmol. Pub Date : 2024-01-01 Mohammad Ayoubi, Kimberly Cabrera, Simran Mangwani, Elyana Vittoria Tessa Locatelli, Anat Galor
Background/aims To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE. Methods 141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE symptoms (5-Item Dry Eye Questionnaire (DEQ-5) and Ocular Surface Disease Index (OSDI)) and ocular pain
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase inhibitors on endothelial cell loss protocol BMJ Open Ophthalmol. Pub Date : 2024-01-01 Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Bennie H Jeng, Nicole Varnado, Sarah Abdelrahman, Benjamin F Arnold, Thomas M Lietman, Jennifer Rose-Nussbaumer
Background It remains uncertain which endothelial keratoplasty (EK) technique yields the best outcomes while maintaining safety, particularly in eyes with coexisting ocular conditions. Moreover, the impact of endothelial cell loss (ECL) on long-term graft survival requires further investigation. Adjuvant ripasudil, a rho kinase inhibitor, may address the challenge of ECL in corneal transplantation
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Effect of the gut microbiome in glaucoma risk from the causal perspective BMJ Open Ophthalmol. Pub Date : 2024-01-01 Yaxuan Wu, Ronghua Shi, He Chen, Zicheng Zhang, Siqi Bao, Jia Qu, Meng Zhou
Objective Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined. Methods and analysis We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma. Genome-wide association study summary statistics
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Performance outcomes from a DMEK peeling and preparation wet lab BMJ Open Ophthalmol. Pub Date : 2024-01-01 Mohit Parekh, Alexander George Wallace, Matteo Airaldi, Alessandro Ruzza, Stefano Ferrari, Vito Romano, Sajjad Ahmad
Objective To evaluate the Descemet membrane endothelial keratoplasty (DMEK) preparation performance of trainee surgeons in an ex vivo human donor cornea DMEK wet lab simulation setting. Methods Human donor corneoscleral rims unsuitable for transplantation were obtained from Moorfields Lions Eye Bank. At the wet lab, graft stripping was performed by scoring the peripheral endothelium. The trypan blue
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Selective retina therapy with real-time feedback-controlled technology in central serous chorioretinopathy: a 24-month follow-up real-world prospective study BMJ Open Ophthalmol. Pub Date : 2024-01-01 Chang Ki Yoon, Hyeong Gon Yu
Objective Although central serous chorioretinopathy (CSC) treatment using selective retinal therapy (SRT) has presented favourable outcomes, no long-term studies with a real-world clinical practice regimen have been conducted. Methods and analysis We performed a long-term assessment of CSC treatment using SRT with real-time feedback (RTF) technology. 50 patients (53 eyes) with CSC and more than a 1-month
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Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study BMJ Open Ophthalmol. Pub Date : 2024-01-01 Qiaona Ye, Kezheng Xu, Zidong Chen, Zitian Liu, Yanmei Fan, Pingping Liu, Minbin Yu, Yangfan Yang
Objective To explore different performances in the magnocellular (MC) and parvocellular (PC) visual pathways in patients with primary open-angle glaucoma (POAG) and to objectively assess impairment in early stage of POAG. Methods and analysis This is a cross-sectional study. MC and PC visual pathways were assessed using isolated-check visual evoked potential (ic-VEP). Visual acuity, intraocular pressure
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Eyecare practitioner perspectives and attitudes towards myopia and myopia management in the UK BMJ Open Ophthalmol. Pub Date : 2024-01-01 Sophie Coverdale, Lindsay Rountree, Kathryn Webber, Matthew Cufflin, Edward Mallen, Alison Alderson, Neema Ghorbani-Mojarrad
Objective Many children with progressive myopia are still prescribed single-vision correction. An investigation into UK eyecare practitioners’ (ECPs) perceptions of myopia management was carried out to ascertain factors which may be limiting its implementation and uptake within clinical practice. Methods and analysis Online focus groups were held with UK ECPs. Participants were encouraged to discuss
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Feasibility of an artificial intelligence phone call for postoperative care following cataract surgery in a diverse population: two phase prospective study protocol BMJ Open Ophthalmol. Pub Date : 2024-01-01 Amin Hatamnejad, Aisling Higham, Sohel Somani, Eric S Tam, Ernest Lim, Sarah Khavandi, Nick de Pennington, Hannah H Chiu
Introduction Artificial intelligence (AI) development has led to improvements in many areas of medicine. Canada has workforce pressures in delivering cataract care. A potential solution is using AI technology that can automate care delivery, increase effectiveness and decrease burdens placed on patients and the healthcare system. This study assesses the use of ‘Dora’, an example of an AI assistant
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Effect of mount location on the quantification of light intensity in myopia study BMJ Open Ophthalmol. Pub Date : 2023-12-01 Longbo Wen, Hong Liu, Zhao Chen, Qinglin Xu, Ziqi Hu, Weizhong Lan, Zhikuan Yang
Purpose To investigate how the mounting location of wearable devices affects the measurement of light intensity. Methods Two commercially available wearable devices, HOBO and Clouclip, were used to compare the effects of different mount locations on light intensity measurement. We assessed the consistency of the measurements of the two devices by placing a HOBO and a Clouclip simultaneously in 26 different
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Novel tactile bottle neck adaptor facilitates eye drop adherence in visually impaired patients BMJ Open Ophthalmol. Pub Date : 2023-12-01 Praveena K Gupta, Rhys Ishihara, Zhenyang Zhao, Shahin Owji, Easy Anyama, Mary Schmitz-Brown, Aisen C Chacin, Bhavani Iyer, David Friedman, Malik Said Ladki
Purpose To test the use of Ring-IT, a novel 3D tactile bottle neck adaptor in topical eye drop adherence in visually impaired patients. Methods Bottle neck ring adaptors with either one, two or three protrusions with cube or sphere endings were designed. In phase 1, low vision was simulated in healthy subjects (n=20) with a 20/200 vision simulator; while in phase 2, visually impaired patients (n=26;
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Incident glaucoma and ocular hypertension after periocular and intravitreal steroid injections: a claims-based analysis BMJ Open Ophthalmol. Pub Date : 2023-12-01 Ashley Polski, Katy C Liu, Divakar Gupta, Dilraj S Grewal, Joshua Horns, Barbara M Wirostko, Brian C Stagg
Background/aims This study aims to determine the incidence and risk of open-angle glaucoma or ocular hypertension (OHT) following ocular steroid injections using healthcare claims data. Methods We retrospectively reviewed deidentified insurance claims data from the IBM MarketScan Database to identify 19 156 adult patients with no prior history of glaucoma who received ocular steroid injections between
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Real-world evaluation of smartphone-based artificial intelligence to screen for diabetic retinopathy in Dominica: a clinical validation study BMJ Open Ophthalmol. Pub Date : 2023-12-01 Oliver Kemp, Covadonga Bascaran, Edyta Cartwright, Lauren McQuillan, Nanda Matthew, Hazel Shillingford-Ricketts, Marcia Zondervan, Allen Foster, Matthew Burton
Objective Several artificial intelligence (AI) systems for diabetic retinopathy screening have been validated but there is limited evidence on their performance in real-world settings. This study aimed to assess the performance of an AI software deployed within the diabetic retinopathy screening programme in Dominica. Methods and analysis We conducted a prospective, cross-sectional clinical validation
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Classification of diabetic maculopathy based on optical coherence tomography images using a Vision Transformer model BMJ Open Ophthalmol. Pub Date : 2023-12-01 Liwei Cai, Chi Wen, Jingwen Jiang, Congbi Liang, Hongmei Zheng, Yu Su, Changzheng Chen
Purpose To develop a Vision Transformer model to detect different stages of diabetic maculopathy (DM) based on optical coherence tomography (OCT) images. Methods After removing images with poor quality, a total of 3319 OCT images were extracted from the Eye Center of the Renmin Hospital of Wuhan University and randomly split the images into training and validation sets in a 7:3 ratio. All macular cross-sectional
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Biosimilar SB15 versus reference aflibercept in neovascular age-related macular degeneration: 1-year and switching results of a phase 3 clinical trial BMJ Open Ophthalmol. Pub Date : 2023-12-01 Se Joon Woo, SriniVas R Sadda, Mario Bradvica, Attila Vajas, Min Sagong, Jan Ernest, Jan Studnička, Miroslav Veith, Edward Wylegala, Sunil Patel, Cheolmin Yun, Michal Orski, Sergei Astakhov, Edit Tóth-Molnár, Adrienne Csutak, Lajos Enyedi, Wooree Choi, Inkyung Oh, Hyerin Jang
Background/aims To evaluate efficacy, safety, pharmacokinetics (PK) and immunogenicity of SB15 versus reference aflibercept (AFL), and switching from AFL to SB15 in neovascular age-related macular degeneration (nAMD). Design Prospective, double-masked, randomised, phase 3 trial. Methods Participants with nAMD were randomised 1:1 to receive SB15 (N=224 participants) or AFL (N=225). At week 32, participants
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Quality assessment of non-mydriatic fundus photographs for glaucoma screening in primary healthcare centres: a real-world study BMJ Open Ophthalmol. Pub Date : 2023-12-01 Qi Chen, Mengtian Zhou, Yang Cao, Xuanli Zheng, Huiyan Mao, Changrong Lei, Wanglong Lin, Junhong Jiang, Yize Chen, Di Song, Xiang Xu, Cong Ye, Yuanbo Liang
Background This study assessed the quality distribution of non-mydriatic fundus photographs (NMFPs) in real-world glaucoma screening and analysed its influencing factors. Methods This cross-sectional study was conducted in primary healthcare centres in the Yinzhou District, China, from 17 March to 3 December 2021. The quality distribution of bilateral NMFPs was assessed by the Digital Reading Department
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Evaluating the long-term biological stability of cytokine biomarkers in ocular fluid samples BMJ Open Ophthalmol. Pub Date : 2023-12-01 Tina Felfeli, Jeff Park, Bret Nestor, Filiberto Altomare, Amandeep S Rai, Efrem D Mandelcorn, David R Chow, David T Wong
Purpose The quality of biological fluid samples is vital for optimal preanalytical procedures and a requirement for effective translational biomarker research. This study aims to determine the effects of storage duration and freeze-thawing on the levels of various cytokines in the human aqueous humour and vitreous samples. Methods and analysis Human ocular aqueous humour and vitreous samples were obtained
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Hypochlorous acid hygiene solution in patients affected by blepharitis: a prospective randomised study BMJ Open Ophthalmol. Pub Date : 2023-12-01 Rita Mencucci, Alberto Morelli, Eleonora Favuzza, Angelo Galano, Anna Maria Roszkowska, Michela Cennamo
Background/aims To investigate the clinical outcomes and antimicrobial activity of an hypochlorous acid hygiene solution compared with hyaluronic acid wipes for blepharitis treatment in patients with dry eye disease (DED). Methods This study involved 48 eyes of 48 patients affected by blepharitis with mild to moderate DED. 24 patients were treated with a hypochlorous acid hygiene solution (HOCL group)
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Colour tone of retinal arterioles imaged with a colour scanning laser ophthalmoscope can be an indicator of systemic arterial stiffness BMJ Open Ophthalmol. Pub Date : 2023-12-01 Takato Sakono, Hiroto Terasaki, Takuro Kubozono, Shozo Sonoda, Ryoh Funatsu, Naohisa Mihara, Hideki Shiihara, Mitsuru Ohishi, Taiji Sakamoto
Objective Colour scanning laser ophthalmoscope (cSLO) offers several advantages, including improved image quality and better visualisation of the retinal structures compared with colour fundus photograph (CFP). This study aimed to identify whether cSLO could be used to predict systemic arterial stiffness. Methods and analysis We retrospectively analysed the data of 54 patients with 103 eyes. In addition
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Non-pharmacological pain relief interventions in preterm neonates undergoing screening for retinopathy of prematurity: a systematic review BMJ Open Ophthalmol. Pub Date : 2023-12-01 Iretiola Bamikeolu Fajolu, Iyabode Olabisi Florence Dedeke, Beatrice Nkolika Ezenwa, Veronica Chinyere Ezeaka
Objective The objective of this review was to determine the efficacy of non-pharmacological interventions for pain management during retinopathy of prematurity (ROP) screening. Methods and analysis Electronic search of Ovid MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, Google Scholar and ClinicalTrials.gov (USA) was conducted
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Explainable artificial intelligence model for the detection of geographic atrophy using colour retinal photographs BMJ Open Ophthalmol. Pub Date : 2023-12-01 Valentina Sarao, Daniele Veritti, Axel De Nardin, Micaela Misciagna, Gianluca Foresti, Paolo Lanzetta
Objective To develop and validate an explainable artificial intelligence (AI) model for detecting geographic atrophy (GA) via colour retinal photographs. Methods and analysis We conducted a prospective study where colour fundus images were collected from healthy individuals and patients with retinal diseases using an automated imaging system. All images were categorised into three classes: healthy
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Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination BMJ Open Ophthalmol. Pub Date : 2023-12-01 Iliana Georganta, Despoina Chasapi, Charlotte Jayne Smith, Konstantinos Kopsidas, Andrew Tatham
Background This study aims to characterise the symptoms and clinical features of optic neuritis (ON) following SARS-CoV-2 infection and vaccination. Method A literature search was conducted in four databases (PubMed, Medline, Embase and Google Scholar) to identify relevant case reports and case series. The records were screened and articles adhering to the inclusion criteria were critically appraised
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Descemet membrane endothelial keratoplasty compared with ultrathin Descemet stripping automated endothelial keratoplasty: a meta-analysis BMJ Open Ophthalmol. Pub Date : 2023-11-01 Tal Corina Sela, Moti Iflah, Khitam Muhsen, Alon Zahavi
Aims This study aims to compare the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) and ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) in patients with corneal endothelial dysfunction due to Fuchs’ endothelial dystrophy or pseudophakic bullous keratopathy. Methods We conducted a meta-analysis using a literature search of Embase, PubMed, Cochrane CENTRAL
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Multivariate analysis of repeatability for the Near Eye Tool for Refractive Assessment (NETRA) BMJ Open Ophthalmol. Pub Date : 2023-11-01 Nabeela Hasrod, Alan Rubin
Objective To investigate repeatability of refractive state using a smartphone-based assessment tool, the Near Eye Tool for Refractive Assessment (NETRA). Methods and analysis This study included 279 participants, predominantly female (66.7%) of African descent (49.1%). The age range was 9–63 years with mean age ( s ) 22.6 (8.9) years. Two consecutive measurements per eye with the NETRA were measured
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OCT and OCTA in dysthyroid optic neuropathy: a systematic review and meta-analysis BMJ Open Ophthalmol. Pub Date : 2023-11-01 Nan Yang, Hui Zhu, Junxin Ma, Qing Shao
Purpose To explore the current research about the role of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in dysthyroid optic neuropathy (DON). Methods Studies in the literature that focused on OCT, OCTA and DON were retrieved by searching PubMed, EMBASE, Cochrane databases and Clinical Trial before 20 June 2023. The methodological quality was assessed using the
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Effect of music on preoperative anxiety using the Hamilton State-Trait Anxiety Inventory (STAI) in patients undergoing cataract surgery in the University of Nigeria Teaching Hospital, Ituku Ozalla BMJ Open Ophthalmol. Pub Date : 2023-11-01 Chukwubuike Obiora Ezepue, Obinna Princewill Anyatonwu, Christian Chukwuka Duru, Franklin Odini, Chidimma Onoh, Nwamaka Nwachukwu, Chukwunonso Afam Oguonu
Introduction To determine the effectiveness of music in allaying preoperative anxiety in patients scheduled for and undergoing surgery for age-related cataract. Methods This is a randomised interventional study of individuals aged 50 years and above who were scheduled for and undergoing cataract surgery under regional anaesthesia, with music (test group) randomly matched with similar individuals undergoing
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Impact of a handpiece with a built-in fluidics pressure sensor on phacoemulsification: a multicentre prospective comparative study BMJ Open Ophthalmol. Pub Date : 2023-11-01 Antoine P Brézin, Dominique Monnet, François Lignereux, Pascal Rozot, Lea Jilet, Hendy Abdoul
Objective We assessed whether the immediate pressure adjustments provided by a phacoemulsification handpiece with a built-in pressure sensor (Active Sentry, AS) could decrease the amount of energy delivered in the eye during cataract surgery. Methods and analysis The Study of Active Sentry in Cataract Surgery was a multicentre prospective clinical trial. The Centurion system (Alcon Labs) was used and
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Role of excessive weight in intraocular pressure: a systematic review and meta-analysis BMJ Open Ophthalmol. Pub Date : 2023-11-01 Noro Waspodo, Moh Anfasa Giffari Makkaraka, Ririn Nislawati, Abrar Ismail, Ahmad Taufik Fadillah Zainal, Giordano Bandi Lolok
Objective This systematic review and meta-analysis aimed to analyse the effect of excess body weight on intraocular pressure (IOP) values. Method and analysis A literature search from PubMed, Medline and ScienceDirect Databases on 18 May 2023 was conducted by three reviewers, then filtered each study based on inclusion and exclusion criteria. For the quality assessment of included studies, the Newcastle–Ottawa
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Risk factors associated with progression from papilloedema to optic atrophy: results from a cohort of 113 patients BMJ Open Ophthalmol. Pub Date : 2023-11-01 Ruben Attia, Ruben Fitoussi, Kevin Mairot, Sarah Demortiere, Jan-Patrick Stellman, Penelope Tilsley, Bertrand Audoin, Thierry David, Natacha Stolowy
Background The aim of this study was to assess the risk factors for atrophic progression of patients with papilloedema secondary to intracranial hypertension, using optical coherence tomography parameters. Methods A retrospective study was conducted at Marseille University Hospitals’ Ophthalmology departments between December 2015 and December 2021. All patients with papilloedema resulting from elevated
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Demographic and socioeconomic disparities in receipt of ophthalmology consultation for facial trauma BMJ Open Ophthalmol. Pub Date : 2023-10-01 Kalla A Gervasio, Joab Camarena, Jessica Hampton, Nitin Chopra, Brittany Kalosza, Lauren Shumate, Albert Y Wu
Objective Functional outcomes following facial and ocular trauma are time-sensitive and require prompt evaluation to minimise long-term vision loss, yet few studies have systematically evaluated disparities in the management of these cases. This study investigates whether a patient’s race/ethnicity, primary language, insurance status, gender or age affects receipt of ophthalmology consultation for
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Prediction of refractive error and its progression: a machine learning-based algorithm BMJ Open Ophthalmol. Pub Date : 2023-10-01 Maria J Barraza-Bernal, Arne Ohlendorf, Pablo Sanz Diez, Xiancai Feng, Li-Hua Yang, Mei-Xia Lu, Siegfried Wahl, Timo Kratzer
Objective Myopia is the refractive error that shows the highest prevalence for younger ages in Southeast Asia and its projection over the next decades indicates that this situation will worsen. Nowadays, several management solutions are being applied to help fight its onset and development, nonetheless, the applications of these techniques depend on a clear and reliable assessment of risk to develop
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17 Development of a questionnaire to study fear and anxiety factors affecting patients and their families undergoing strabismus surgery. BMJ Open Ophthalmol. Pub Date : 2023-10-01 G Hogg,S Joshi,H Mason,C O'Byrne,S Jain
Patients and their Families undergoing Strabismus Surgery. The aim of this study was to develop a questionnaire to identify perioperative fear and anxiety factors affecting pediatric strabismus surgery patients.First, we reviewed the literature to determine precipitants of fears and anxieties experienced by pediatric patients. Subsequently, we developed a questionnaire for pediatric patients undergoing
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1 Retreatment for reactivation of ROP following initial anti-VEGF injections. A 5-year retrospective study. BMJ Open Ophthalmol. Pub Date : 2023-10-01 E Kollia,H Razzouk,S Biswas,J Ashworth
To present the retreatment rates and the characteristics of ROP reactivation, as well as the differences between bevacizumab and ranibizumab injections in premature babies treated in our department over the past 5 years.A retrospective analysis of babies with treated ROP was performed. 89 babies who required treatment from 2017 to 2022 were examined. We studied the severity of their disease with regards
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7 Scoping review of homonymous hemianopia in childhood. BMJ Open Ophthalmol. Pub Date : 2023-10-01 S E Handley,D A Thompson,A Liasis,R J Bowman,J S Rahi
Cerebral visual impairment (CVI) encompasses a heterogeneous group of disorders and a spectrum of types of visual impairments. Research is needed to characterise the different forms of CVI and identify the specific needs of these groups to inform individualised patient care. Homonymous hemianopia (HH) is a definable visual field defect that affect some children with CVI. As part of a new research programme
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19 Unilateral lateral rectus resection as preferred procedure to treat patients with acquired distance esotropia. BMJ Open Ophthalmol. Pub Date : 2023-10-01 W Ghaffari,N Mansoor-Ali,R Sadia,A Maino
To report the results of a series of patients with acquired distance esotropia (ET) who underwent lateral rectus resection.We retrospectively analysed data from 21 symptomatic patients with acquired esotropia who did not tolerate prisms. Twelve patients had myopic esotropia, 5 patients decompensated esophoria and 4 patients age-related distance esotropia. Patients were divided in two groups; myopic
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24 Primary outcomes of management of convergence excess esotropia at moorfields eye hospital. BMJ Open Ophthalmol. Pub Date : 2023-10-01 D Elfadaly,A-M Hinds
Convergence excess ET (CXE) is an esotropia with binocular single vision (BSV) at distance fixation but esotropia on accommodation for near fixation with near distance disparity (1). In this retrospective chart review our 1ry question:to evaluate the initial treatment to address CXE, whether this treatment successful or not, secondary question: to evaluate primary and final outcomes for control of
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11 Convergence insufficiency: are we making a difference in patients' lives or is it a waste of time! BMJ Open Ophthalmol. Pub Date : 2023-10-01 Jlz Jong,Z Saleem,J Simmons,M Rhodes,J L Choi
Convergence insufficiency (CI) is a common condition that can impair visual performance and comfort during close visual work. This prospective study evaluated the effectiveness of interventions on clinical outcomes and quality-of-life using the adult strabismus quality-of-life questionnaire (AS20) in patients with CI.Data was extracted from a database collected at first consultation from 2015 to 2022
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2 Pathways to detection of non-infectious childhood uveitis in the UK: findings from the UNICORN cohort study. BMJ Open Ophthalmol. Pub Date : 2023-10-01 S Kellett,H Petrushkin,J Ashworth,A Connor,E McLoone,C Schmoll,S Sharma,E Agorogiannis,J Williams,J Choi,A Injarie,N Puvanachandra,P Watts,A Shafi,E Millar,V Long,A Kumar,E Hughes,A Ritchie,J Gonzalez-Martin,A Pradeep,S Anwar,K Warrior,B Muthusamy,R Pilling,J Benzimra,A Reddy,K Bush,D Pharoah,K Falzon,U O'Colmain,R Knowles,V Tadic,A Dick,J Rahi,A L Solebo
Prompt detection of childhood uveitis is key to minimising negative impact. From an internationally unique inception cohort, we report pathways to disease detection.UNICORNS is a national childhood non-infectious uveitis study with longitudinal collection of a standardised clinical dataset and patient reported outcomes. Descriptive analysis of baseline characteristics are reported.Amongst 150 recruited
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12 The incidence, clinical features, and management of essential infantile esotropia in the United Kingdom. A British Ophthalmology Surveillance Unit (BOSU) study - Final Report. BMJ Open Ophthalmol. Pub Date : 2023-10-01 P Watts,D Yeo,R Davis,W J Watkins
Studies from the UK have reported declining rates of surgery for childhood esotropia. It is not known if this equates to a reduced incidence of essential infantile esotropia (EIE). A national study was undertaken through the British ophthalmology surveillance unit (BOSU) to determine the incidence presenting features and management of EIE in the UKData from a prospective national observational cohort
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18 Engaging with young people to improve research, services and workforce development: eye-YPAG and 'visually' workshops. BMJ Open Ophthalmol. Pub Date : 2023-10-01 V Tailor,L M Brady,J Miller,L Bays,J Zane,G Nagel,H Baker,R Crosby-Nwaobi,A Dahlmann-Noor
Involving children and young people (CYP) in service and research design improves quality and accessibility. Running events in schools to invite CYP to volunteer and explore careers in the NHS may contribute to uptake of training posts and developing the NHS workforce.Here we evaluate two activities with CYP, our Young Person's Advisory Group for research (eye-YPAG) and our workshop for secondary schools
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14 Surgical treatment of heavy eye syndrome by modified loop myopexy. BMJ Open Ophthalmol. Pub Date : 2023-10-01 A Agrawal,Vsy Geh
Heavy eye syndrome or convergent strabismus fixus is an acquired strabismus typically seen in eyes with high myopia. We present a case, discuss the aetiology and management, and include a short video illustrating the surgical procedure undertaken.A 47-year-old highly myopic woman with h/o bilateral cataract surgery and B/L scleral buckling for retinal detachments, had left esotropia and hypotropia
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27 Chiasmal misrouting in infantile nystagmus syndrome (INS): phenotypes in patients with molecular diagnoses. BMJ Open Ophthalmol. Pub Date : 2023-10-01 M J Gilhooley,M Moosajee,M M Neveu,M Theodorou
Chiasmal misrouting, once believed to be pathognomonic for albinism, has been reported in cases of INS, independent of melanin pathway disruption. The purpose of this study is to determine if there are clinical-electrophysiological parameters that correlate with particular genotypes in INS.A retrospective chart review at Moorfields Eye Hospital identified 71 patients with a molecular diagnosis relating
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4 Peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children: optical coherence tomography measurements and refractive status. BMJ Open Ophthalmol. Pub Date : 2023-10-01 L Pratt,S Rehan,J West,P Watts
Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a recently described entity. They are a common and non-specific cause of pseudopapilloedema. We aim to determine if there is a relationship between optical coherence tomography (OCT) measurements and refractive status on the presence of PHOMS.Retrospective analysis of optic nerve head OCT scans from children seen in the suspected
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8 Unexpected retinopathy in a patient presenting with bilateral optic disc swelling. BMJ Open Ophthalmol. Pub Date : 2023-10-01 G Kiray,V Panteli,N Enright,S Handley,O Marmoy,D Thompson,R Henderson
A 12-year-old boy presented with 5 day history of blurry vision, 'wobbly eyes', tinnitus and difficulty seeing at night. Local ophthalmology noted bilateral optic disc swelling and referred him urgently for neurological investigations.Clinical Findings: At presentation VA was RE 0.00 and LE 0.2 with normal Ishihara colour vision. His extraocular movements were full without manifest strabismus. Fundoscopy
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5 Tear proteins in premature babies at risk of retinopathy of prematurity. BMJ Open Ophthalmol. Pub Date : 2023-10-01 C Shipton,J Aitken,S Atkinson,R Burchmore,R Hamilton,H MacTier,S McGill,E Millar,A C Houtman
This feasibility study aimed to investigate the feasibility of collecting and analysing tear proteins from preterm infants at risk of retinopathy of prematurity (ROP). Additionally, we sought to identify any tear proteins which might be implicated in the pathophysiology of ROP.Eligible infants were those undergoing ROP screening without other ocular pathology. Tear samples were obtained by Schirmer's
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Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study BMJ Open Ophthalmol. Pub Date : 2023-10-01 Takashi Nishida, Eleonora Micheletti, Kareem Latif, Kelvin H Du, Robert N Weinreb, Sasan Moghimi
Objective To investigate the effect of smoking on choroidal microvasculature dropout (MvD) in glaucoma. Design Cross-sectional study. Setting Tertiary glaucoma centre. Participants 223 eyes of 163 patients with primary open-angle glaucoma who had undergone imaging with optical coherence tomography angiography and completed a questionnaire on smoking from the Diagnostic Innovations in Glaucoma Study