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A Computational Framework for Intraoperative Pupil Analysis in Cataract Surgery medRxiv. Ophthalmol. Pub Date : 2024-03-15 Binh Duong Giap, Karthik Srinivasan,, Ossama Mahmoud, Dena Ballouz, Jefferson Lustre, Keely Likosky, Shahzad I. Mian, Bradford L. Tannen, Nambi Nallasamy
Purpose: Pupillary instability is a known risk factor for complications in cataract surgery. This study aims to develop and validate an innovative and reliable computational framework for the automated assessment of pupil morphologic changes during the various phases of cataract surgery. Design: Retrospective surgical video analysis. Subjects: Two hundred forty complete surgical video recordings, among
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Creating an Early Diagnostic Method for Glaucoma Using Convolutional Neural Networks medRxiv. Ophthalmol. Pub Date : 2024-03-15 Areej A. Alqarni, Sanad H. Al Harbi, Irshad A. Subhan
According to the World Health Organization, glaucoma is a leading cause of blindness, accounting for over 12% of global blindness as it affects one in every 100 people. In fact, 79.6 million people worldwide live with blindness caused by glaucoma. This is because the current method for diagnosing glaucoma is by examining retinal fundus images. However, it is considerably difficult to distinguish the
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Exploring WNT2 Polymorphisms in Comitant Strabismus: A Genetic Association Study medRxiv. Ophthalmol. Pub Date : 2024-03-14 Zainab Zehra, Christopher S von Bartheld, Andrea B. Agarwal, Hans Vasquez-Gross, Sorath Noorani Siddiqui, Maleeha Azam, Raheel Qamar
Abstract Background: Strabismus is a complex oculomotor condition characterized by a misalignment of the visual axis. The genetics of strabismus are poorly defined although a few candidate genes have been identified, among which is the WNT2 gene. Our study was designed to assess the association of single nucleotide polymorphisms (SNPs) of WNT2 in Pakistani strabismus patients. Methods: A total of six
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Great expectations: Aligning visual prosthetic development with implantee needs medRxiv. Ophthalmol. Pub Date : 2024-03-14 Lucas Gil Nadolskis, Lily M Turkstra, Ebenezer Larnyo, Michael Beyeler
Purpose: Visual prosthetics have emerged as a promising assistive technology for individuals with vision loss, yet research often overlooks the human aspects of this technology. While previous studies have concentrated on the perceptual experiences of implant recipients (implantees) or the attitudes of potential implantees towards near-future implants, a systematic account of how current implants are
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Automated Detection of Keratorefractive Laser Surgeries on Optical Coherence Tomography using Deep Learning medRxiv. Ophthalmol. Pub Date : 2024-03-11 Jad F. Assaf, Hady Yazbeck, Dan Reinstein, Timothy Archer, Roland Assaf, Diego de Ortueta, Juan Arbelaez, Maria Clara Arbelaez, Shady T Awwad
PURPOSE: To report a deep learning neural network on anterior segment optical coherence tomography (AS-OCT) for automated detection of different keratorefractive laser surgeries, including Laser In-Situ Keratomileusis with femtosecond microkeratome (Femto-LASIK), LASIK with mechanical microkeratome, photorefractive keratectomy (PRK), keratorefractive lenticule extraction (KLEx), and non-operated eyes
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Evaluating the Safety and Efficacy of Topical Insulin for Ocular Disease: A Systematic Review medRxiv. Ophthalmol. Pub Date : 2024-02-29 Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Caroline Santos Franca, Luis Matos de Oliveira
Introduction: Ocular surface disorders are prevalent, impacting millions worldwide and causing significant morbidity. Conventional treatments often fall short in addressing refractory cases. Topical insulin has emerged as a potential therapeutic option. Objective: This systematic review aimed to evaluate the safety and efficacy of topical insulin for ocular diseases. Methods: We conducted a systematic
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Quantitative Characterization of Retinal Features in Translated OCTA medRxiv. Ophthalmol. Pub Date : 2024-02-27 Rashadul Hasan Badhon, Atalie Carina Thompson, Jennifer I. Lim, Theodore Leng, Minhaj Nur Alam
Purpose: This study explores the feasibility of using generative machine learning (ML) to translate Optical Coherence Tomography (OCT) images into Optical Coherence Tomography Angiography (OCTA) images, potentially bypassing the need for specialized OCTA hardware. Methods: The method involved a generative adversarial network framework that includes a 2D vascular segmentation model and a 2D OCTA image
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Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy medRxiv. Ophthalmol. Pub Date : 2024-02-24 Wenjing Liu, Shujin Li, Mu Yang, Jie Ma, Lu Liu, Ping Fei, Qianchun Xiang, Lulin Huang, Peiquan Zhao, Zhenglin Yang, Xianjun Zhu
Familial exudative vitreoretinopathy (FEVR) is a severe genetic disorder characterized by incomplete vascularization of the peripheral retina and associated symptoms that can lead to vision loss. However, the underlying genetic causes of approximately 50% of FEVR cases remain unknown. Here, we report two heterozygous variants, c.88C>T (p.Arg30Ter) and c.247C>T (p.Leu83Phe), in calcyphosine like (CAPSL)
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The Gut Metabolism is altered in patients with CRB1-associated inherited retinal degeneration medRxiv. Ophthalmol. Pub Date : 2024-02-23 Lude Moekotte, Joke H. de Boer, Sanne Hiddingh, Bram Gerritsen, Jutta Lintelmann, Alexander Cecil, L. Ingeborgh van den Born, Xuan-Thanh-An Nguyen, Camiel J.F. Boon, Maria M. van Genderen
Purpose: To compare the plasma metabolic profile of patients with a CRB1-associated inherited retinal degeneration (CRB1-IRD) with healthy controls (HCs). Design: A case-control study. Methods: Plasma concentration of 619 metabolites was measured with the MxP® Quant 500 Kit in 30 patients with a CRB1-IRD and 29 HCs. We fitted a linear regression model with adjustments for age and sex based on the concentration
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Artificial intelligence to facilitate clinical trial recruitment in age-related macular degeneration medRxiv. Ophthalmol. Pub Date : 2024-02-17 Dominic J. Williamson, Robbert R. Struyven, Fares Antaki, Mark A. Chia, Siegfried K. Wagner, Mahima Jhingan, Zhichao Wu, Robyn Guymer, Simon S. Skene, Naaman Tammuz, Blaise Thomson, Reena Chopra, Pearse A. Keane
Background: Recent developments in artificial intelligence (AI) have positioned it to transform several stages of the clinical trial process. In this study, we explore the role of AI in clinical trial recruitment of individuals with geographic atrophy (GA), an advanced stage of age-related macular degeneration, amidst numerous ongoing clinical trials for this condition. Methods: Using a diverse retrospective
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Ageing Biomarkers Derived From Retinal Imaging: A Scoping Review medRxiv. Ophthalmol. Pub Date : 2024-02-14 Michaela Joan Grimbly, Sheri-Michelle Koopowitz, Alice Ruiye Chen, Zihan Sun, Paul J Foster, Mingguang He, Dan J Stein, Jonathan C Ipser, Lisa Zhuoting Zhu
Background/Aims: The emerging concept of retinal age, a biomarker derived from retinal images, holds promise in estimating biological age. The retinal age gap (RAG) represents the difference between retinal age and chronological age which serves as an indicator of deviations from normal ageing. This scoping review aims to collate studies on retinal age to determine its potential clinical utility and
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AI and the Eye - Integrating deep learning and in silico simulations to optimise diagnosis and treatment of wet macular degeneration medRxiv. Ophthalmol. Pub Date : 2024-02-14 Remi J Hernandez, Yalin Zheng, Savita Madhusudhan, Wahbi K El-Bouri
This protocol describes the A-EYE Study and provides information about procedures for entering participants. Every care was taken in its drafting, but corrections or amendments may be necessary. These will be circulated to investigators in the Study. Problems relating to this Study should be referred, in the first instance, to the Chief Investigator. This study will adhere to the principles outlined
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Myopia and hyperopia are associated with opposite chronotypes in a sample of 71,016 individuals medRxiv. Ophthalmol. Pub Date : 2024-02-13 Teele Palumaa, Nele Taba, Maris Teder-Laving, Kadi-Liis Kivi, Kadri Reis, Urmo Võsa, Estonian Biobank Research Team, Tõnu Esko, Erik Abner
Myopia, projected to affect half of the global population by 2050, is a growing healthcare concern. Chronotype, an output of the human biological clock, and sleep parameters have been associated with several diseases, including myopia. We explored the connection between refractive errors and sleep and circadian rhythm parameters by employing a sample of 71,016 adults who completed the Munich Chronotype
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Active Mutual Conjoint Estimation of Multiple Contrast Sensitivity Functions medRxiv. Ophthalmol. Pub Date : 2024-02-13 Dom CP Marticorena, Quinn Wai Wong, Jake Browning, Ken Wilbur, Pinakin Gunvant Davey, Aaron R Seitz, Jacob R Gardner, Dennis Barbour
Recent advances in nonparametric Contrast Sensitivity Function (CSF) estimation have yielded a new tradeoff between accuracy and efficiency not available to classical parametric estimators. An additional advantage of this new framework is the ability to independently tune multiple aspects of the estimator to seek further improvements. Machine Learning CSF (MLCSF) estimation with Gaussian processes
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Recurrent and Concurrent Prediction of Longitudinal Progression of Stargardt Atrophy and Geographic Atrophy medRxiv. Ophthalmol. Pub Date : 2024-02-13 Zubin Mishra, Ziyuan Chris Wang, Emily Xu, Sophia Xu, Iyad Majid, SriniVas Reddy Sadda, Zhihong Jewel Hu
Stargardt disease and age-related macular degeneration are the leading causes of blindness in the juvenile and geriatric populations, respectively. The formation of atrophic regions of the macula is a hallmark of the end-stages of both diseases. The progression of these diseases is tracked using various imaging modalities, two of the most common being fundus autofluorescence (FAF) imaging and spectral-domain
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Vitreous fluid-isolated DNA for the genetic analysis of primary uveal melanoma: a proof-of-concept study medRxiv. Ophthalmol. Pub Date : 2024-02-10 R. J. Nell, M. Versluis, N. V. Menger, M. C. Gelmi, T. H.K. Vu, R. M. Verdijk, G. P.M. Luyten, M. J. Jager, P. A. van der Velden
Background Uveal melanoma is an aggressive ocular malignancy. Early molecular characterisation of primary tumours is crucial to identify those at risk of metastatic dissemination. Although tumour biopsies are being taken, liquid biopsies of ocular fluids may form a less invasive but relatively unexplored alternative. In this study, we aim to evaluate the DNA content of vitreous fluid from eyes with
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Topo-Net: Retinal Image Analysis with Topological Deep Learning medRxiv. Ophthalmol. Pub Date : 2024-02-07 Faisal Ahmed, Baris Coskunuzer
The analysis of fundus images for the early screening of eye diseases is of great clinical importance. Traditional methods for such analysis are time-consuming and expensive as they require a trained clinician. Therefore, the need for a comprehensive and automated clinical decision support system to diagnose and grade retinal diseases has long been recognized. In the past decade, with the substantial
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Multicenter normative data for mesopic microperimetry medRxiv. Ophthalmol. Pub Date : 2024-02-06 Maximilian Pfau, Jasleen K Jolly, Jason Charng, Leon von der Emde, Philipp L. Mueller, Georg Ansari, Kristina Pfau, Fred K Chen, Zhichao Wu
Purpose: To provide a large, multi-center normative dataset for the Macular Integrity Assessment (MAIA) microperimeter and compare the goodness-of-fit and prediction interval calibration-error for a panel of hill-of-vision models. Methods: Microperimetry examinations from five independent study groups and one previously available dataset were included. Linear mixed models (LMMs) were fitted to the
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Comparison of Leucocyte Telomere Length, Atherosclerotic Cardiovascular disease risk, using retinal imaging medRxiv. Ophthalmol. Pub Date : 2024-02-03 Ehsan Vaghefi, Songyang An, Rini Corbett, David Squirrell
Significance. That a retinal image based Deep Learning (DL) Cardiac BioAge Model may be a useful novel tool that can personalise an individuals risk of Atherosclerotic cardiovascular disease (ASCVD) events. Purpose. To determine whether the results issued by our DL Cardiac BioAge model are consistent with the known trends of cardiovascular disease (CVD) risk and the biomarker Leucocyte Telomere Length
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Digital PCR-based deep quantitative profiling delineates heterogeneity and evolution of uveal melanoma medRxiv. Ophthalmol. Pub Date : 2024-02-02 Rogier J. Nell, Mieke Versluis, Nino V. Menger, Robert M. Verdijk, Wilma G.M. Kroes, Ellen H.W. Kapiteijn, Gregorius P.M. Luyten, Martine J. Jager, Pieter A. van der Velden
Uveal melanoma is an aggressive intraocular tumour characterised by a limited number of genetic alterations. However, the evolution of this malignancy remains enigmatic. In this study, we performed a deep quantitative analysis of 80 primary uveal melanomas by novel digital PCR-based approaches. Mutations were quantified by targeted and drop-off mutation assays, copy number alterations were precisely
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Ophthalmic Manifestations of NAA10-Related and NAA15-Related Neurodevelopmental Syndrome: Analysis of Cortical Visual Impairment and Refractive Errors medRxiv. Ophthalmol. Pub Date : 2024-02-02 Rahi Patel, Agnes Park, Elaine Marchi, Andrea Gropman, Matthew Whitehead, Gholson J Lyon
NAA10-related and NAA15-related neurodevelopmental syndrome, otherwise known as Ogden Syndrome, is known to present with varying degrees of intellectual disability, hypotonia, congenital cardiac abnormalities, seizures, and delayed speech and motor development. However, the ophthalmic manifestations of NAA10 and NAA15 mutations are not yet fully characterized or understood. This study analyzed the
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Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: a Mendelian randomization mediation analysis medRxiv. Ophthalmol. Pub Date : 2024-02-01 Andreas Katsimpris, Sebastian-Edgar Baumeister, Nafiska Anastasia Voulgari, Hansjörg Baurecht, Stylianos Kandarakis, Michael Nolde
Background: The etiological connection between intraocular pressure (IOP) and the risk of retinal vein occlusion (RVO) remains elusive, particularly regarding whether this risk emanates from the direct influence of elevated intraocular pressure (IOP), irrespective of the presence of primary open-angle glaucoma (POAG), or if it arises as a consequence of the sequelae of POAG. Therefore, we conducted
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Performance of GPT-4V(ision) in Ophthalmology: Use of Images in Clinical Questions medRxiv. Ophthalmol. Pub Date : 2024-01-28 Kosei Tomita, Takashi Nishida, Yoshiyuki Kitaguchi, Masahiro Miyake, Koji Kitazawa
Background/aims: To compare the diagnostic accuracy of Generative Pre-trained Transformer with Vision (GPT)-4 and GPT-4 with Vision (GPT-4V) for clinical questions in ophthalmology. Methods: The questions were collected from the "Diagnosis This" section on the American Academy of Ophthalmology website. We tested 580 questions and presented GPT-4V with the same questions under two conditions: 1) multimodal
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Efficacy of Transposition of Plicated Medial Rectus Muscles in the Treatment of Pattern Exotropia (A Comparative Study) medRxiv. Ophthalmol. Pub Date : 2024-01-26 Lamiaa A. El-aidy, Yasser M. Ibrahim, Mohamed A. Elmarakby, Manar A. Ghali
PURPOSE To report effectiveness of bimedial plication and vertical transposition for the correction of exotropia associated with A- or V-pattern and compare it with bimedial resection and vertical transposition. METHODS We retrospectively reviewed the results of surgery of patients who underwent bimedial plication (group I) versus bimedial resection (group II) with vertical offset to correct both exotropia
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Prevalence and types of strabismus in cerebral palsy: A global and historical perspective based on a systematic review and meta-analysis medRxiv. Ophthalmol. Pub Date : 2024-01-24 Michael S Herron, Lingchen Wang, Christopher S von Bartheld
Purpose. Strabismus is more frequent in cerebral palsy (CP) than in the normal population, but reports differ how much it is increased. We here examined the global prevalence and types of strabismus in CP, whether esotropia or exotropia is more frequent, and whether the prevalence differs between ethnicities and/or country income levels, and between generations. Methods. We compiled in a systematic
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BRSET: A Brazilian Multilabel Ophthalmological Dataset of Retina Fundus Photos medRxiv. Ophthalmol. Pub Date : 2024-01-23 Luis Filipe Nakayama, David Restrepo, Joao Matos, Lucas Zago Ribeiro, Fernando Korn Malerbi, Leo Anthony Celi, Caio Saito Regatieri
Introduction: The Brazilian Multilabel Ophthalmological Dataset (BRSET) addresses the scarcity of publicly available ophthalmological datasets in Latin America. BRSET comprises 16,266 color fundus retinal photos from 8,524 Brazilian patients, aiming to enhance data representativeness, serving as a research and teaching tool. It contains sociodemographic information, enabling investigations into differential
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DR-GPT: a large language model for medical report analysis of diabetic retinopathy patients medRxiv. Ophthalmol. Pub Date : 2024-01-17 Joel Jaskari, Jaakko Sahlsten, Paula Summanen, Jukka Moilanen, Erika Lehtola, Marjo Aho, Elina Säpyskä, Kustaa Hietala, Kimmo Kaski
Diabetic retinopathy (DR) is a sight-threatening condition caused by diabetes. Screening programmes for DR include eye examinations, where the patient’s fundi are photographed, and the findings, including DR severity, are recorded in the medical report. However, statistical analyses based on DR severity require structured labels that calls for laborious manual annotation process if the report format
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Multispectral Fundus Photography of Choroidal Nevi with Trans-Palpebral Illumination medRxiv. Ophthalmol. Pub Date : 2024-01-13 Mojtaba Rahimi, Alfa Rossi, Taeyoon Son, Albert K. Dadzie, Behrouz Ebrahimi, Mansour Abtahi, Michael J. Heiferman, Xincheng Yao
Purpose To investigate the spectral characteristics of choroidal nevi and assess the feasibility of quantifying the basal diameter of choroidal nevi using multispectral fundus images captured with trans-palpebral illumination.
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Microbiological Culture Versus 16S/18S Ribosomal RNA PCR-Sanger Sequencing for Infectious Keratitis: A Three-Arm, Diagnostic Cross-Sectional Study medRxiv. Ophthalmol. Pub Date : 2024-01-12 Yasmeen Hammoudeh, Lakshmi Suresh, Zun Zheng Ong, Michelle M. Lister, Imran Mohammed, D. John I. Thomas, Jennifer L. Cottell, Jennifer M. Holden, Dalia G. Said, Harminder S. Dua, Darren Shu Jeng Ting
Purpose To compare the diagnostic performance of microbiological culture and 16S/18S polymerase chain reaction (PCR)-Sanger sequencing for infectious keratitis (IK) and to analyse the effect of clinical disease severity on test performance and inter-test concordance.
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Highly accurate and precise automated cup-to-disc ratio quantification for glaucoma screening medRxiv. Ophthalmol. Pub Date : 2024-01-11 Abadh K Chaurasia, Connor J Greatbatch, Xikun Han, Puya Gharahkhani, David A Mackey, Stuart MacGregor, Jamie E Craig, Alex W Hewitt
Objective An enlarged cup-to-disc ratio (CDR) is a hallmark of glaucomatous optic neuropathy. Manual assessment of CDR may be inaccurate and time-consuming. Herein we sought to develop and validate a deep-learning-based algorithm to automatically determine CDR from fundus images.
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Ocular manifestations in autoimmune rheumatic diseases. medRxiv. Ophthalmol. Pub Date : 2024-01-10 Usama Sohail
Background. Autoimmune disorders involve diverse symptomatic manifestations constituting an abnormal or exaggerated immune function and serve to attack self-antigens and result in tissue destruction. This study aims to comprehensively analyse the prevalence, type, associative factors, and the resultant impact of ocular symptoms on patients presented to rheumatology departments of multi-centre tertiary
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Axonal stimulation affects the linear summation of single-point perception in three Argus II users medRxiv. Ophthalmol. Pub Date : 2023-12-26 Yuchen Hou, Devyani Nanduri, Jacob Granley, James D. Weiland, Michael Beyeler
Purpose Retinal implants use electrical stimulation to elicit perceived flashes of light (“phosphenes”). Single-electrode phosphene shape has been shown to vary systematically with stimulus parameters and the retinal location of the stimulating electrode, due to incidental activation of passing nerve fiber bundles. However, this knowledge has yet to be extended to paired-electrode stimulation.
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography medRxiv. Ophthalmol. Pub Date : 2023-12-22 Jingyu Wang, Natalie Sadlak, Marissa G. Fiorello, Manishi Desai, Ji Yi
Purpose Oxygen saturation (sO2) plays a critical role in retinal pathophysiology, especially at the macula, which undergoes significant energy consumption. While macular damage has been suggested to be involved in early-stage glaucoma, there has been no report to date on non-invasive macular sO2 in glaucoma. Therefore, we conducted this study to compare macular sO2 associated with other clinical measurements
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Training in cortically-blind fields confers patient-specific benefit against retinal thinning after occipital stroke medRxiv. Ophthalmol. Pub Date : 2023-12-20 Berkeley K Fahrenthold, Matthew R Cavanaugh, Madhura Tamhankar, Byron L Lam, Steven E Feldon, Brent A Johnson, Krystel R Huxlin
Purpose: Damage to the adult primary visual cortex (V1) causes vision loss in the contralateral hemifield, initiating a process of trans-synaptic retrograde degeneration (TRD). Here, we examined retinal correlates of TRD using a new metric to account for global changes in inner retinal thickness, and asked if perceptual training in the intact or blind field impacts its progression. Methods: We performed
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Equitable Artificial Intelligence for Glaucoma Screening with Fair Identity Normalization medRxiv. Ophthalmol. Pub Date : 2023-12-14 Min Shi, Yan Luo, Yu Tian, Lucy Shen, Tobias Elze, Nazlee Zebardast, Mohammad Eslami, Saber Kazeminasab, Michael V. Boland, David S. Friedman, Louis R. Pasquale, Mengyu Wang
Objective To develop an equitable artificial intelligence model for glaucoma screening.
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Analyzing morphological alternations of vessels in multiple Sclerosis using SLO images of the eyes medRxiv. Ophthalmol. Pub Date : 2023-12-14 Asieh Soltanipour, Roya Arian, Ali Aghababaei, Raheleh Kafieh, Fereshteh Ashtari
Background Our purpose was to investigate the most relevant and discriminating clinical feature set of Scanning laser ophthalmoscopy (SLO) images, which could differentiate multiple sclerosis (MS) and healthy control (HC) patients.
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The Natural History of Vision-Related Quality of Life after Unilateral Occipital Stroke medRxiv. Ophthalmol. Pub Date : 2023-12-01 Neil Dogra, Bryan V. Redmond, Selena Lilley, Brent A. Johnson, Byron L. Lam, Madhura Tamhankar, Steven E. Feldon, Berkeley Fahrenthold, Jingyi Yang, Krystel R. Huxlin, Matthew R. Cavanaugh
Background/Objectives Stroke damage to the primary visual cortex induces large, homonymous visual field defects that impair daily living. Here, we asked if vision-related quality of life (V-QoL) is impacted by time since stroke.
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Multiple genome-wide association studies of type 2 diabetes implicate several genes are associated with diabetic retinopathy based on UK Biobank medRxiv. Ophthalmol. Pub Date : 2023-12-03 Tengda Cai, Qi Pan, Yiwen Tao, Charvi Nangia, Aravind Lathika Rajendrakumar, Tania Dottorini, Mainul Haque, Colin Palmer, Weihua Meng
Purpose To identify the genetic variants associated with diabetic retinopathy in type 2 patients from the UK Biobank cohort (n = 17,015) and supporting replication cohorts GODARTS (n = 5,013), GOSHARE (n = 1,754), Caucasian Australians (n = 518), FinnGen (n = 206,664) and Chinese (n = 1,007). Methods Totally eleven genome-wide association studies were applied to search for significant genetic variants
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Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomization mediation analysis medRxiv. Ophthalmol. Pub Date : 2023-11-29 Andreas Katsimpris, Sebastian-Edgar Baumeister, Hansjörg Baurecht, Andrew J Tatham, Michael Nolde
The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although, several observational studies assessing this relationship, have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomization (MR) the effect of CCT on POAG
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Evaluation of a digital ophthalmologist app built by GPT4-V(ision) medRxiv. Ophthalmol. Pub Date : 2023-11-29 Pusheng Xu, Xiaolan Chen, Ziwei Zhao, Yingfeng Zheng, Guangming Jin, Danli Shi, Mingguang He
Backgrounds: GPT4-V(ision) has generated great interest across various fields, while its performance in ocular multimodal images is still unknown. This study aims to evaluate the capabilities of a GPT-4V-based chatbot in addressing queries related to ocular multimodal images. Methods: A digital ophthalmologist app was built based on GPT-4V. The evaluation dataset comprised various ocular imaging modalities:
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Angiographic Report Generation for the 3rd APTOS’s Competition: Dataset and Baseline Methods medRxiv. Ophthalmol. Pub Date : 2023-11-27 Weiyi Zhang, Peranut Chotcomwongse, Xiaolan Chen, Florence H.T. Chung, Fan Song, Xueli Zhang, Mingguang He, Danli Shi, Paisan Ruamviboonsuk
Fundus angiography, including fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA), are essential examination tools for visualizing lesions and changes in retinal and choroidal vasculature. However, the interpretation of angiography images is labor-intensive and time-consuming. In response to this, we are organizing the third APTOS competition for automated and interpretable
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GPT-4 Multimodal Analysis on Ophthalmology Clinical Cases Including Text and Images medRxiv. Ophthalmol. Pub Date : 2023-11-27 Vera Sorin, Noa Kapelushnik, Idan Hecht, Ofira Zloto, Benjamin S. Glicksberg, Hila Bufman, Yiftach Barash, Girish N. Nadkarni, Eyal Klang
Objective Recent advancements in GPT-4 have enabled analysis of text with visual data. Diagnosis in ophthalmology is often based on ocular examinations and imaging, alongside the clinical context. The aim of this study was to evaluate the performance of multimodal GPT-4 (GPT-4V) in an integrated analysis of ocular images and clinical text.
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Using electronic health record data to determine the safety of aqueous humor liquid biopsies for molecular analyses medRxiv. Ophthalmol. Pub Date : 2023-11-23 Julian Wolf, Teja Chemudupati, Aarushi Kumar, Joel A. Franco, Artis A. Montague, Charles C. Lin, Wen-Shin Lee, A. Caroline Fisher, Jeffrey L. Goldberg, Prithvi Mruthyunjaya, Robert T. Chang, Vinit B. Mahajan
Purpose Knowing the surgical safety of anterior chamber liquid biopsies will support the increased use of proteomics and other molecular analyses to better understand disease mechanisms and therapeutic responses in patients and clinical trials. Manual review of operative notes from different surgeons and procedures in electronic health records (EHR) is cumbersome, but free-text software tools could
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Development of the Advised Protocol for OCT Study Terminology and Elements Anterior Segment OCT extension reporting guidelines: APOSTEL-AS medRxiv. Ophthalmol. Pub Date : 2023-11-22 Ameenat L Solebo, Edmund Tsui, Alastair K Denniston, Axel Petzold, Alex S Huang
Background Anterior segment optical coherence tomography (AS-OCT) is emerging as a valuable diagnostic, monitoring and predictive tool across a range of disorders. Clinical utility of quantitative information derived from AS-OCT has been suggested for ophthalmic disorders such as glaucoma, corneal disease and uveitis, which taken together comprise the majority of the blinding conditions affecting working
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Clinical applicability of the WaveFront Phase Imaging Sensor in the Keratoconus Disease medRxiv. Ophthalmol. Pub Date : 2023-11-20 Carolina Belda-Para, Gonzalo Velarde-Rodríguez, Miriam Velasco-Ocaña, Juan M. Trujillo-Sevilla, Iván Rodríguez-Méndez, Javier Rodríguez-Martin, Nicolas Alejandre-Alba, Silvia Rodríguez-García, José M. Rodríguez-Ramos
Significance The analysis of the wavefront phase of keratoconus eyes has become increasingly important due to its impact on the assessment of visual quality loss, irrecoverable with conventional optical treatments, and the understanding of morphological changes in corneal structures.
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The impact of pre-existing eye donation awareness of the next of kin on donation rate after grief counseling - A cross-sectional study. medRxiv. Ophthalmol. Pub Date : 2023-11-16 Oshin Puri, Neeti Gupta, Sanjeev Mittal
This cross-sectional study was conducted to assess the impact of pre-existing eye donation awareness of the next of kin on the donation rate after grief counseling with due ethical approval. The N=164 most stable next-of-kin, mostly the Brother (20.7%) or Father (20.1%) of the deceased, were approached by the Eye Donation Counselor (EDC). After assessing their awareness about eye donation through the
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Self-supervised contrastive learning improves machine learning discrimination of full thickness macular holes from epiretinal membranes in retinal OCT scans medRxiv. Ophthalmol. Pub Date : 2023-11-15 Tim Wheeler, Kaitlyn Hunter, Patricia Anne Garcia, Henry Li, Andrew Thomson, Allan Hunter, Courosh Mehanian
There is a growing interest in using computer-assisted models for the detection of macular conditions using optical coherence tomography (OCT) data. As the quantity of clinical scan data of specific conditions is limited, these models are typically developed by fine-tuning a generalized network to classify specific macular conditions of interest. Full thickness macular holes (FTMH) present a condition
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Prosthetic Visual Acuity with the PRIMA System in Patients with Atrophic Age-related Macular Degeneration at 4 years follow-up medRxiv. Ophthalmol. Pub Date : 2023-11-13 MAHIUL MK MUQIT, YANNICK LE MER, LISA C OLMOS DE KOO, FRANK G HOLZ, JOSE A SAHEL, Daniel Palanker
Objective: To assess the efficacy and safety of the PRIMA subretinal neurostimulation system 48-months post-implantation for improving visual acuity (VA) in patients with geographic atrophy (GA) due to age-related macular degeneration (AMD) at 48-months post-implantation. Design: First-in-human clinical trial of the PRIMA subretinal prosthesis in patients with atrophic AMD, measuring best-corrected
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Impact of Anti-VEGF Treatment for Diabetic Macular Oedema on Progression to Proliferative Diabetic Retinopathy: Data-driven Insights from a Multicentre Study medRxiv. Ophthalmol. Pub Date : 2023-11-12 Abraham Olvera-Barrios, Watjana Lilaonitkul, Tjebo FC Heeren, Assaf Rozenberg, Darren Thomas, Alasdair N Warwick, Taha Somroo, Abdulrahman H Alsaedi, Roy Schwartz, Usha Chakravarthy, Haralabos Eleftheriadis, Ashish Patwardhan, Faruque Ghanchi, Paul Taylor, Adnan Tufail, Catherine Egan, UK DR EMR Users Group
Background: To report insights on proliferative-diabetic-retinopathy (PDR) risk modification with repeated anti-vascular endothelial-growth-factor (VEGF) injections for the treatment of diabetic-macular-oedema (DMO) in routine care, and present data-driven PDR screening recommendations for injection clinics. Methods: Multicentre study (27 UK-NHS centres) of patients with non-PDR with and without DMO
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Interpretable Detection of Epiretinal Membrane from Optical Coherence Tomography with Deep Neural Networks medRxiv. Ophthalmol. Pub Date : 2023-11-12 Murat Seckin Ayhan, Jonas Neubauer, Mehmet Murat Uzel, Faik Gelisken, Philipp Berens
Purpose: To automatically detect epiretinal membranes (ERMs) of different sizes in various OCT scans of the central and paracentral macula region and classify them by size using deep neural networks (DNNs). Methods: 11,061 OCT-images of 624 volume OCT scans (624 eyes of 461 patients) were included and graded according to the presence of an ERM and its size (small 100-1000 um, large >1000 um). The data
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A mechanical model of ocular bulb vibrations and implications for acoustic tonometry medRxiv. Ophthalmol. Pub Date : 2023-11-11 Nicoletta Tambroni, Giuseppe Tomassetti, Silvia Lombardi, Rodolfo Repetto
In this study, we propose a comprehensive mechanical model of ocular bulb vibrations and discuss its implications for acoustic tonometry; the model describes the eye wall as a spherical, pre-stressed elastic shell containing a viscoelastic material and accounts for the interaction between the elastic corneoscleral shell and the viscoelastic vitreous humor, investigating the natural frequencies of the
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Elevated Plasma Complement Factors in CRB1-associated Inherited Retinal Dystrophies medRxiv. Ophthalmol. Pub Date : 2023-11-10 Lude Moekotte, Joke H. Boer, Sanne Hiddingh, Aafke Ligt, Xuan-Thanh-An Nguyen, Carel B. Hoyng, Chris F. Inglehearn, Martin McKibbin, Tina M. Lamey, Jennifer A. Thompson, Fred K. Chen, Terri L. McLaren, Alaa AlTalbishi, Daan M. Panneman, Erica G.M. Boonen, Sandro Banfi, Beatrice Bocquet, Isabelle Meunier, Elfride Baere, Robert Koenekoop, Monika Oldak, Carlo Rivolta, Lisa Roberts, Raj Ramesar, Rasa
Objective: To determine the profile of inflammation-related proteins and complement system factors in serum of CRB1-associated inherited retinal dystrophies (CRB1-IRDs). Design: A case-control study. Subjects, Participants, and/or Controls: A cohort of 30 Dutch CRB1-IRD patients and 29 Dutch healthy controls (HC) (Cohort I), and a second cohort of 123 CRB1-IRD patients from 14 countries and 1292 controls
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Disease-specific variant interpretation highlighted the genetic findings in 2325 Japanese patients with retinitis pigmentosa and allied diseases medRxiv. Ophthalmol. Pub Date : 2023-11-10 Kensuke Goto, Yoshito Koyanagi, Masato Akiyama, Yusuke Murakami, Masatoshi Fukushima, Kohta Fujiwara, Hanae Iijima, Mitsuyo Yamaguchi, Mikiko Endo, Kazuki Hashimoto, Masataka Ishizu, Toshiaki Hirakata, Kei Mizobuchi, Masakazu Takayama, Junya Ota, Ai Fujita Sajiki, Taro Kominami, Hiroaki Ushida, Kosuke Fujita, Hiroki Kaneko, Shinji Ueno, Takaaki Hayashi, Chikashi Terao, Yoshihiro Hotta, Akira Murakami
Background: As gene–specific therapy for inherited retinal dystrophy (IRD) advances, unified variant interpretation across institutes is becoming increasingly important. This study aims to update the genetic findings of 86 retinitis pigmentosa (RP)–related genes in a large number of Japanese RP patients by applying the standardized variant interpretation guidelines for Japanese IRD patients (J–IRD–VI
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Diagnostic accuracy of a remote eye exam in measuring refractive errors and detecting cataract, glaucoma, and diabetic retinopathy medRxiv. Ophthalmol. Pub Date : 2023-11-10 Tais De Campos Moreira, Cassia Garcia Moares Pagano, Maria Eulalia Vinade Chagas, Maicon Falavigna, Dimitris Rucks Varvaki Rados, Rodolfo Souza Silva, Erno Harzheim, Marcelo Rodrigues Goncalves, Roberto Nunes Umpierre, Pietro Baptista de Azevedo, Alice Paul Waquil, Caroline Fabris, Martha Pereira Lima Lang, Adriana Dietrich Szortika, Anelise Szortyka, Aline Lutz de Araujo, Felipe Cezar Cabral
Porpuse: Approximately 2.2 billion people worldwide have some type of visual impairment and among these, many could have been avoided or solved if adequate care had been provided in a timely manner. In these cases, telemedicine can assist in solving the problems of many ophthalmological conditions by providing support, performing screening, telediagnosis or supervision of distant appointments. The
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Founder Mutation Effect Seen By CERKL Gene Mutation Causing Retinal Dystrophy in North Indian Population medRxiv. Ophthalmol. Pub Date : 2023-11-09 Mayank Bansal, Debojyoti Chakraborty
Purpose: This paper describes the clinical features, genotype phenotype correlation of CERKL gene mutation, one of the most common genetic mutations of Inherited Retinal Dystrophy (IRD) patients seen in our cohort in North India. Materials and Methods: Patients clinically diagnosed with an IRD were included in the study. Patients underwent ultra widefield (UWF) fundus photographs, fundus autofluorescence
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Association of optic disc parameters and glaucoma incidence based on automated segmentation, evidence from the UK Biobank medRxiv. Ophthalmol. Pub Date : 2023-11-07 Pinxuan Zhu, Shuang He, Danli Shi, Mingguang He
Objective: To assess the correlation between glaucoma incidence and optic disc parameters obtained through an automated deep learning (DL) algorithm segmentation. Methods and Analysis : We obtained eligible fundus photographs and corresponding participant data from the UK Biobank. To accurately assess the optic disc parameters and their relationship with glaucoma incidence using Cox proportional hazard
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Disease modeling and pharmacological rescue of autosomal dominant Retinitis Pigmentosa associated with RHO copy number variation medRxiv. Ophthalmol. Pub Date : 2023-11-06 Sangeetha Kandoi, Cassandra Martinez, Kevin Chen, Miika Mehine, L Vinod K Reddy, Brian Mansfield, Jacque L Duncan, Deepak A Lamba
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO), account for ~25% cases of autosomal dominant RP (adRP). In this study, we describe the disease characteristics of the first ever reported mono-allelic copy number variation (CNV) in RHO as a novel cause of adRP
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Prevalence and causes of blindness and visual impairment in Kogi state, Nigeria – Findings from a Rapid Assessment of Avoidable Blindness survey. medRxiv. Ophthalmol. Pub Date : 2023-11-01 Selben Penzin, Emma Jolley, Kolawole Ogundimu, Caleb Mpyet, Nazaradden Ibrahim, Foluso Owoeye, Sunday Isiyaku, Joy Shu'aibu, Elena Schmidt
Purpose To determine the prevalence and causes of blindness and visual impairment among adults in Kogi, Nigeria. Methods A Rapid assessment of avoidable blindness (RAAB) protocol was used with additional tools measuring disability and household wealth to measure the prevalence of blindness and visual impairment (VI) and associations with sex, disability, wealth, cataract surgical coverage and its effectiveness
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Time-resolved dynamic optical coherence tomography for retinal blood flow analysis medRxiv. Ophthalmol. Pub Date : 2023-11-01 Philippe Valmaggia, Philippe C. Cattin, Robin Sandkuehler, Nadja Inglin, Tilman P. Otto, Silke Aumann, Michel M. Teussink, Richard F. Spaide, Hendrik P. N. Scholl, Peter M. Maloca
Purpose: Optical coherence tomography (OCT) representations in clinical practice are static and do not allow for a dynamic visualisation and quantification of blood flow. This study aims to present a method to analyse retinal blood flow dynamics using time-resolved structural optical coherence tomography (OCT). Methods: We developed novel imaging protocols to acquire video-rate time-resolved OCT B-scans
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VisualR: a novel and scalable solution for assessing visual function using virtual reality medRxiv. Ophthalmol. Pub Date : 2023-10-28 Federica Sozzi, Henning Gross, Bratislav Ljubisic, Jascha Adams, Andras Gyacsok, Giuseppe Graziano, Steffen Weiss, Nuno D. Pires
Background: Diagnosis and treatment of progressive eye diseases require effective monitoring of visual structure and function. However, current methods for measuring visual function are limited in accuracy, reliability, and usability. We propose a novel approach that leverages virtual reality (VR) technology to overcome these challenges, enabling more comprehensive measurements of visual function endpoints