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Delivering Personalized, Goal-Directed Care to Older Patients Receiving Peritoneal Dialysis. Kidney Dis. (IF 3.7) Pub Date : 2023-06-23 Henry H L Wu,Dimitrios Poulikakos,Helen Hurst,David Lewis,Rajkumar Chinnadurai
Background An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some degree of frailty. Recent practice recommendations from the International Society of Peritoneal Dialysis advocate for high-quality, goal-directed PD
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Construction of an Early Alert System for Intradialytic Hypotension before Initiating Hemodialysis Based on Machine Learning. Kidney Dis. (IF 3.7) Pub Date : 2023-06-23 Daqing Hong,Huan Chang,Xin He,Ya Zhan,Rongsheng Tong,Xingwei Wu,Guisen Li
Introduction Intradialytic hypotension (IDH) is prevalent and associated with high hospitalization and mortality rates. The purpose of this study was to explore the risk factors for IDH and use artificial intelligence to establish an early alert system before hemodialysis sessions to identify patients at high risk of IDH. Materials and Methods We obtained data on 314,534 hemodialysis sessions conducted
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Genetic Diagnosis and Treatment of Inherited Renal Tubular Acidosis. Kidney Dis. (IF 3.7) Pub Date : 2023-06-20 Wenkai Guo,Pengcheng Ji,Yuansheng Xie
Background Renal tubular acidosis (RTA) is caused by various disruptions to the secretion of H+ by distal renal tubules and/or dysfunctional reabsorption of HCO3- by proximal renal tubules, which causes renal acidification dysfunction, ultimately leading to a clinical syndrome characterized by hyperchloremic metabolic acidosis with a normal anion gap. With the development of molecular genetics and
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Cognitive Impairment in Chronic Kidney Disease Is Associated with Glymphatic System Dysfunction. Kidney Dis. (IF 3.7) Pub Date : 2023-06-14 Shuqin Xu,Jiuqi Wang,Kedi Sun,Lin Meng,Chi Qin,Renyi Feng,Yiming Tian,Yanping Zhai,Dongxiao Liang,Rui Zhang,Haiyan Tian,Han Liu,Yongkang Chen,Yu Fu,Pei Chen,Qingyong Zhu,Junfang Teng,Xuejing Wang
Introduction This study was designed to explore the associations between impaired cognition in chronic kidney disease (CKD) patients and the dysfunction of the glymphatic system. Method Data were obtained from 77 CKD patients and 50 age-matched healthy control individuals from the First Affiliated Hospital of Zhengzhou University. CKD patients were stratified into with and without impaired cognitive
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Impact of Angiotensin Receptor Blockers Use on In-Hospital Mortality in Community-Acquired Pneumonia Patients with Hypertension. Kidney Dis. (IF 3.7) Pub Date : 2023-06-14 Dawei Chen,Yan Tan,Xin Wan
Introduction This study aimed to explore the association of angiotensin receptor blockers (ARBs) use with in-hospital mortality among Chinese patients with hypertension hospitalized with community-acquired pneumonia (CAP). Methods This study was conducted from January 2014 to January 2017, and data from patients with hypertension hospitalized with CAP were analyzed retrospectively. Multivariable logistic
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Development and Validation of a Nomogram for Renal Survival Prediction in Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney Dis. (IF 3.7) Pub Date : 2023-06-06 Xiaomei Wang,Rui Zheng,Zhende Liu,Ling Qi,Liang Gu,Xiaoping Wang,Shan Zhu,Mingyue Zhang,Danya Jia,Zhen Su
Introduction Due to the wide variation in the prognosis of autosomal dominant polycystic kidney disease (ADPKD), prediction of risk of renal survival in ADPKD patients is a tough challenge. We aimed to establish a nomogram for the prediction of renal survival in ADPKD patients. Methods We conducted a retrospective observational cohort study in 263 patients with ADPKD. The patients were randomly assigned
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Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond. Kidney Dis. (IF 3.7) Pub Date : 2023-05-25 Lirong Zhang,Zhiheng Liu,Yumei Lu,Jing Nie,Yupeng Chen
Background The formation of biomolecular condensates via phase separation has emerged as a fundamental principle underlying the spatiotemporal coordination of biological activities in cells. Aberrant biomolecular condensates often directly regulate key cellular process involved in the pathogenesis of human diseases, including kidney diseases. Summary In this review, we summarize the physiological roles
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The Role of Anti-mCRP Autoantibodies in Lupus Nephritis. Kidney Dis. (IF 3.7) Pub Date : 2023-05-15 Mo Yuan,Ying Tan,Ming-Hui Zhao
Background Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis. CRP exists in at least two conformationally distinct forms: native pentameric C-reactive protein (pCRP) and modified/monomeric CRP (mCRP). Autoantibodies against mCRP are prevalent in sera of patients with lupus nephritis and are reported
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Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence Kidney Dis. (IF 3.7) Pub Date : 2023-04-11 Junhao Lv, Luying Guo, Rending Wang, Jianghua Chen
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents in patients with type-2 diabetes. However, available data from clinical trials and meta-analyses suggest that SGLT2i have pleiotropic benefits in reducing mortality and delaying the progression of chronic kidney disease (CKD) in both diabetic and nondiabetic patients. Thus, we herein review
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Strategies to improve long-term outcomes for patients with chronic kidney disease in China Kidney Dis. (IF 3.7) Pub Date : 2023-04-11 Jing Liu, Yunying Shi, Yongshu Diao, Xiaoxi Zeng, Ping Fu
Background: Chronic kidney disease (CKD) is an incurable disease requiring lifelong management. China has a high prevalence of CKD, which disproportionately affects older adults and those with chronic risk factors for CKD development. The rising prevalence of CKD in China places a substantial burden on the general population and the healthcare system. Summary: In China, there are currently many unmet
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From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases Kidney Dis. (IF 3.7) Pub Date : 2023-04-04 Lingge Zhang, Mengqiu Miao, Xinyue Xu, Mi Bai, Mengqiu Wu, Aihua Zhang
Background: Renal diseases remain an increasing public health issue affecting millions of people. The kidney is a highly energetic organ that is rich in mitochondria. Numerous studies have demonstrated the important role of mitochondria in maintaining normal kidney function and in the pathogenesis of various renal diseases, including acute kidney injuries (AKI) and chronic kidney diseases (CKD). Summary:
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Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis Kidney Dis. (IF 3.7) Pub Date : 2023-03-28 Yuting Li, Jiaojiao Fan, Wenping Zhu, Yujia Niu, Mengqiu Wu, Aihua Zhang
Background:Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration function of the glomerulus. Podocyte injury under various stress conditions is the primary pathogenesis and key determinant of focal segmental glomerulosclerosis (FSGS) with prominent clinical manifestations of proteinuria or nephrotic syndrome. Summary:Under physiological conditions
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Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis Kidney Dis. (IF 3.7) Pub Date : 2023-03-28 Yikai Cai, Yunzi Liu, Jun Tong, Yuanmeng Jin, Jian Liu, Xu Hao, Yinhong Ji, Jun Ma, Xiaoxia Pan, Nan Chen, Hong Ren, Jingyuan Xie
Introduction The aim of this study is to develop and validate a risk score for end stage kidney disease (ESKD) in patients with focal segmental glomerulosclerosis (FSGS). Methods Patient with biopsy proven FSGS were enrolled. All the patients were allocated 1:1 to the two groups according to their baseline gender, age and baseline creatinine level by using a stratified randomization method. ESKD was
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Role of IL-6 family cytokines in organ fibrosis Kidney Dis. (IF 3.7) Pub Date : 2023-03-22 Ying Chen, Jiaxin Zhou, Shihui Xu, Jing Nie
Background: Organ fibrosis remains an important cause of high incidence rate and mortality worldwide. The prominent role of interleukin-6 (IL-6) family members represented by IL-6 in inflammation has been extensively studied, and drugs targeting IL-6 have been used clinically. Because of the close relationship between inflammation and fibrosis, researches on the role of IL-6 family members in organ
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Hospitalizations of chronic dialysis patients: a national study in China Kidney Dis. (IF 3.7) Pub Date : 2023-03-20 Hong Chu, Chao Yang, Yu Lin, Jingyi Wu, Guilan Kong, Pengfei Li, Luxia Zhang, Minghui Zhao, China Kidney Disease Network Work Group
Background Patients receiving chronic dialysis are usually with multiple comorbidities and at high-risk for hospitalization, which lead to tremendous healthcare resources utilization. This study aims to explore the characteristics of hospitalizations among chronic dialysis patients in China. Methods Hospital admissions from January 2013 to December 2015 were extracted from a national inpatient database
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Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor Kidney Dis. (IF 3.7) Pub Date : 2023-03-17 Qi Yu, Ying Chen, Youlu Zhao, Shuo Huang, Xiaohong Xin, Lei Jiang, Hui Wang, Wenyan Wu, Lei Qu, Chengang Xiang, Suxia Wang, Gang Liu, Li Yang
Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic mechanisms and few effective clinical therapies. DKD progression is accompanied by the loss of renal resident cells, followed by chronic inflammation and extracellular matrix deposition. Necroptosis is a newly discovered form of regulated cell death and is a major form of intrinsic
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A panoramic view of ferroptosis in cardiovascular disease Kidney Dis. (IF 3.7) Pub Date : 2023-03-15 Xihao Cheng, Chao Yu, Xinquan Yang, Fudi Wang, Junxia Min
Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-dependent form of programmed cell death, is characterized by the lethal accumulation of lipid peroxidation, which is morphologically, biochemically and genetically distinct from apoptosis, necrosis and pyroptosis. Emerging evidence provides exciting novel insights to allow for a deeper
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Impact of Angiopoietin-2 on Kidney Diseases Kidney Dis. (IF 3.7) Pub Date : 2023-03-14 Mei Li, Zoran Popovic, Chang Chu, Christoph Reichetzeder, Wolfgang Pommer, Bernhard K. Krämer, Berthold Hocher
Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist
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Clinical Outcomes in Patients on Hemodialysis with Congestive Heart Failure Kidney Dis. (IF 3.7) Pub Date : 2023-03-03 Xinju Zhao, Liangying Gan, Qingyu Niu, Fan Fan Hou, Xinlin Liang, Xiaonong Chen, Yuqing Chen, Junhui Zhao, Keith McCullough, Zhaohui Ni, Li Zuo
Introduction: Congestive heart failure (CHF) is one of the common complications in patients with end-stage kidney disease. In the general population, CHF increases the risk of the death. However, there is no well-designed relevant study in the Chinese hemodialysis (HD) population addressing the risks associated with CHF. The aim of this study was to explore the impact of CHF on clinical outcomes in
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Renal involvement in autoinflammatory diseases Kidney Dis. (IF 3.7) Pub Date : 2023-02-28 Changming Zhang, Jiahui Peng, Zhihong Liu, Qing Zhou
Background: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and caused by dysregulation of the innate immune system leading to episodes of systemic inflammation. Advances in next-generation sequencing and biological technology have resulted in the identification of new monogenic diseases and the corresponding signaling pathways that may guide us in targeted therapy. The kidney is
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Exosomes in Diabetic Kidney Disease Kidney Dis. (IF 3.7) Pub Date : 2023-02-14 Jin Wen, Mengru Zeng, Yiya Yang, Yumei Liang, Ping Fu, Zheng Dong
Background: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and a common cause of end-stage kidney disease (ESKD). The incidence of DKD is rising worldwide and associated with increased morbidity and premature mortality, indicating an urgent need to further explore the underlying pathogenesis and potential biomarkers. Exosomes are nanoscale vesicles secreted by all cell types
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Efficacy and safety of belimumab in lupus nephritis patients: a real-world observational study in China Kidney Dis. (IF 3.7) Pub Date : 2023-02-14 Meng Tan, Jing Xu, Ying Tan, Zhen Qu, Feng Yu, Minghui Zhao
BACKGROUND: This study aimed to describe disease activity, clinical outcome and overall patterns of lupus nephritis care in patients who received belimumab in a real-world clinical setting in China. MATERIALS AND METHODS: This observational cohort study included lupus nephritis patients who received belimumab as adjunct therapy. We deeply investigated the characteristics of those patients including
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Defining biventricular abnormalities by cardiac magnetic resonance in pre-dialysis patients with chronic kidney disease Kidney Dis. (IF 3.7) Pub Date : 2023-02-13 Li Qi, Beibei Zhi, Jun Zhang, Lingyan Zhang, Song Luo, Longjiang Zhang
Introduction: To investigate biventricular structural and functional abnormalities in pre-dialysis patients across stages of chronic kidney disease (CKD) by cardiac magnetic resonance (CMR). Methods: Fifty-one CKD patients with CMR exams were retrospectively analyzed. Patients were divided into three groups according to estimated glomerular filtration rate (eGFR): CKD 1 group (patients with normal
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Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease Kidney Dis. (IF 3.7) Pub Date : 2023-02-10 Stephen A. Strugnell, Philipp Csomor, Akhtar Ashfaq, Charles W. Bishop
Abstract Introduction: Parathyroid hormone-lowering responses after administration of three different therapies capable of raising serum total 25-hydroxyvitamin D (25OHD) were evaluated in patients with secondary hyperparathyroidism (SHPT), vitamin D insufficiency (VDI) and stage 3 or 4 chronic kidney disease (CKD). Methods: Sixty-nine adult subjects with intact parathyroid hormone (iPTH) ≥85 and <500
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IL-37 Ameliorates Renal Fibrosis by Restoring CPT1A Mediated Fatty Acid Oxidation in Diabetic Kidney Disease Kidney Dis. (IF 3.7) Pub Date : 2023-01-31
Introduction: Diabetic kidney disease (DKD) is a major source of chronic kidney disease (CKD) and end-stage renal disease (ESRD). The injury of glomerular in DKD is the primary focus, however proximal tubulopathy also is an indispensable factor in the progression of DKD. Interleukin-37 (IL-37), an anti-inflammatory cytokine of IL-1 family member, has been demonstrated to be associated with diabetes
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Clinical characteristics and management of patients with secondary hyperparathyroidism undergoing hemodialysis: a feasibility analysis of electronic health records using Natural Language Processing Kidney Dis. (IF 3.7) Pub Date : 2023-01-23 Alberto Ortiz, Jose Portoles, Maria Dolores Pino-Pino, Jesús Barea, María López, Patricia de Sequera, Borja Quiroga, Rocio Echarri, Mario Prieto Velasco, Rafael Díaz, Gonzalo Gómez Marqués, Pilar Sanchez Perez, Vicens Torregrosa, Mariano Rodriguez, SAVANA Research Group, SENEFRO-BD-SHPT working group
Introduction: This study aimed to assess the feasibility of applying Natural Language Processing (NLP) to analyze real-world data (RWD) and resolve clinical problems in patients with secondary hyperparathyroidism and chronic kidney disease undergoing hemodialysis (SHPT/CKD-HD). The primary objective was to evaluate how well the guidelines-recommended analytical goals are achieved in a Spanish cohort
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Impact of Weight Gain on the Subsequent Survival of New Peritoneal Dialysis Patients Kidney Dis. (IF 3.7) Pub Date : 2023-01-17 Win Hlaing Than, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Kai-Ming Chow, Cheuk-Chun Szeto
Introduction: Obesity at the initiation of dialysis was reported to adversely affect the clinical outcome of peritoneal dialysis (PD) patients, and weight gain is common after started on PD. However, there are few studies on the prognostic implications of weight gain after PD. Methods: We reviewed the change in body weight of 954 consecutive patients during the first 2 years of PD in a single Hong
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Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease Kidney Dis. (IF 3.7) Pub Date : 2023-01-13 Yasunori Iwata, Yusuke Nakade, Masashi Kinoshita, Hemragul Sabit, Riho Nakajima, Kengo Furuichi, Masashi Mita, Maiko Nakane, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kouichi Sato, Megumi Oshima, Shiori Nakagawa, Yuta Yamamura, Hisayuki Ogura, Yoshitaka Koshino, Mitsutoshi Nakada, Takashi Wada
Introduction: The number of patients with chronic kidney disease (CKD) is increasing worldwide. Cognitive impairment is one of the comorbidities of CKD. With the increased number of aged population, novel biomarkers of impaired cognitive function are required. Intra-body profile of amino acid (AA) is reportedly altered in patients with CKD. Although some AAs act as neurotransmitters in the brain, it
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Efficacy and Safety of Sevelamer Carbonate in Chinese Nondialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized, Double-Blind, Parallel-Group Study Kidney Dis. (IF 3.7) Pub Date : 2022-12-15 Wei Chen, Hua-Feng Liu, Qin-Kai Chen, Ming-Hui Zhao, Xiao-Nong Chen, Hong Liu, Jian-Xin Wan, Shao-Mei Li, Meng-Hua Chen, Chun Dai, Hong-Bin Shi, Jia-Li Wei, Hong-Wen Zhao, Li-Hua Wang, Gang Long, Wan-Hong Lu, Ying Tang, Jun-Wei Yang, Li-Ying Cao, Dong-Xing Tang, Yu-Qiong Yang, Xue-Qing Yu
Introduction: Previous studies suggested that sevelamer carbonate is well tolerated with a favorable efficacy and safety profile in both dialysis and nondialysis patients in Europe; however, the efficacy remains controversial, and few studies have examined sevelamer carbonate therapy in other ethnic nondialysis CKD patients. This study assessed the efficacy and safety of sevelamer carbonate in Chinese
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Role of C-Reactive Protein in Kidney Diseases Kidney Dis. (IF 3.7) Pub Date : 2022-12-14 Jiaxiao Li, Junzhe Chen, Hui-yao Lan, Ying Tang
Background: C-reactive protein (CRP) is an acute phase protein and has been found to be a risk factor for acute renal injury (AKI) and chronic kidney diseases (CKD). However, role and mechanisms of CRP in AKI and CKD remain largely unclear. Summary: Clinically, elevated serum CRP is a risk factor or biomarker for patients with AKI and CKD. Interestingly, in critically ill COVID-19 patients, increased
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Loss of Pten in renal tubular cells leads to water retention by upregulating AQP2 Kidney Dis. (IF 3.7) Pub Date : 2022-11-29 Zhuo Sun, Xiaotong Shao, Haotian Wu, Yaxian Zhao, Yidan Cao, Danhua Li, Ying Sun, Qingling Wang
Introduction: Phosphatase and tensin (PTEN) is a multifunctional gene associated with the normal development and physiological function of various tissues including the kidney. However, its role in renal tubular reabsorption function has not been well elucidated. Methods: We generated a renal tubule-specific Pten knockout mouse model by crossing Ptenfl/fl mice with Ksp-Cre transgenic mice, evaluated
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Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients Kidney Dis. (IF 3.7) Pub Date : 2022-11-24 Christina Montgomerie, Jonas Spaak, Marie Evans, Stefan H. Jacobson
Introduction: Complex integrated information on disease mechanisms and in-hospital outcomes in mild to moderate acute kidney injury (AKI) is scarce. Methods: The Stockholm Prospective AKI Cohort Study (SAKIS) included all patients (≥18 years, n = 1,519) with community-acquired AKI (KDIGO criteria) admitted to the nephrology ward at Danderyd University Hospital, Stockholm, Sweden, between 2009 and 2018
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Musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout Kidney Dis. (IF 3.7) Pub Date : 2022-11-21 Ze Li, Li He, Jiali Jiao, Junjie Jia, Haifan Xing, Ting Zhou, Qiming Zhang, Yini Chen, Lixin Jiang, Niansong Wang, Ying Fan
Introduction. Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in patients with gout. Methods. Clinical information, laboratory indicators and MSUS findings were collected
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Eosinophils: A Friend or Foe in human health and diseases Kidney Dis. (IF 3.7) Pub Date : 2022-11-17
Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions are emerging since then. Initially, eosinophils were perceived as terminally-differentiated cytotoxic effector cells. Clearly, eosinophils are capable of playing functions other than immune responses, which is not surprising given their intricate interactions with pathogens as
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The Mechanism of Delayed Ischemic Preconditioning in Alleviating Acute Ischemia/Reperfusion Renal Injury through Treg Mediated by Immature CD11c+ Dendritic Cells Kidney Dis. (IF 3.7) Pub Date : 2022-11-14
Introduction: Renal ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury, and its mechanism is complex involving multiple factors, while delayed ischemic preconditioning (DIPC) has a protective effect on the above process. In our previous study, we found that DIPC can exert its protection on renal IRI by inhibiting the maturation of dendritic cells (DCs), but the mechanism
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Non-steroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection is a New Option for Patients with Chronic Kidney Disease Kidney Dis. (IF 3.7) Pub Date : 2022-11-14 Wenyu Liu, Shengqiang Yu
Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal function by robust anti-inflammatory and antifibrotic functions beyond classical functions of maintaining fluid and electrolyte homeostasis. The application of traditional steroidal MRAs to chronic kidney disease (CKD) has been limited by adverse events, especially when combined with renin-angiotensin system (RAS) inhibitors
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Histone Modifications in Acute Kidney Injury Kidney Dis. (IF 3.7) Pub Date : 2022-11-10 Jun Wang, Fengchen Shen, Feng Liu, Shougang Zhuang
Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. Summary: There are several types of histone modification, including methylation, acetylation, phosphorylation, crotonylation
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Trends of urolithiasis in China: a national study based on hospitalized patients from 2013 to 2018 Kidney Dis. (IF 3.7) Pub Date : 2022-11-07 Qin Wang, Yu Wang, Chao Yang, Jinwei Wang, Ying Shi, Haibo Wang, Luxia Zhang, Ming-Hui Zhao
Introduction To explore the chronological trends in clinical features and utilization of healthcare resources for hospitalized patients with urolithiasis in China. Methods Patients with urolithiasis were extracted from the Hospital Quality Monitoring System, a national database of hospitalized patients in China, based on International Classification of Diseases, Tenth Revision, codes. Variables including
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Monoclonal Gammopathy of Renal Significance: A Molecular Middle Earth between Oncology, Nephrology, and Pathology Kidney Dis. (IF 3.7) Pub Date : 2022-11-02 Vincenzo L’Imperio, Giorgio Cazzaniga, Barbara Vergani, Andrew James Smith, Federico Alberici, Fabio Pagni
Background: The renal biopsy represents a cornerstone in the definition of monoclonal gammopathy of renal significance (MGRS), helping in identifying patients with sub-detectable neoplastic clones (MGUS) that would deserve aggressive chemotherapies. However, the rising complexity of this onco-nephrology field is significantly challenging the daily work of nephrologists and nephropathologists, leading
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Pathological connections between non-alcoholic fatty liver disease and chronic kidney disease Kidney Dis. (IF 3.7) Pub Date : 2022-10-31 Huixia Liu, Chun Zhang, Jing Xiong
Background: Non-alcoholic fatty liver disease and chronic kidney disease are major public health issues worldwide. The clinical burden of non-alcoholic fatty liver disease is not only confined to liver-related morbidity and mortality but it also includes the burden of chronic extrahepatic complications. It is well known that liver and kidney are strictly interconnected in physiological and pathological
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Updates on hypoxia-inducible factor-prolyl hydroxylase inhibitors in the treatment of renal anemia Kidney Dis. (IF 3.7) Pub Date : 2022-10-31 Jing Li, Volker H. Haase, Chuan-Ming Hao
Background: Anemia is a common complication of chronic kidney disease. The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs for the treatment of renal anemia. Summary: Clinical trials have consistently shown that HIF-PHIs can effectively increase hemoglobin in both the dialysis population and the non-dialysis population. The effects of HIF-PHIs in treating
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Aberrant B-Cell Activation in Systemic Lupus Erythematosus Kidney Dis. (IF 3.7) Pub Date : 2022-10-31 Na Kang, Xiaohang Liu, Xujie You, Wenbo Sun, Kabeer Haneef, Xiaolin Sun, Wanli Liu
Background: B lymphocytes (B cells) are essential in humoral response, and their activation is an important first step for the production of antibodies. However, aberrant B-cell activation is common in the development and progression of autoimmune diseases including systemic lupus erythematosus (SLE), which is characterized by the generation of superfluous autoantibodies. SLE exhibits clinical manifestation
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Kidney Histopathology Features of Suspected Intra-Kidney Venous Thromboembolism in Patients with Primary Glomerulonephritis Kidney Dis. (IF 3.7) Pub Date : 2022-10-31 Hui Lu, Zhao Cui, Tang-li Xiao, Su-xia Wang, Ming-hui Zhao
Introduction: Renal vein thromboembolism is a severe complication of nephrotic syndrome. Small thrombus in the intra-kidney venous system cannot be recognized by ultrasonography. The current study was to investigate the kidney pathological features of intra-kidney venous thrombus and their values in clinical practice. Methods: Kidney pathological features of glomerular capillary dilatation and congestion
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Consensus Evidence-Based Clinical Practice Recommendations for the Diagnosis and Treat-To-Target Management of Osteoporosis in Chronic Kidney Disease Stages G4-G5D and Post-transplantation: An Initiative of Egyptian Academy of Bone Health Kidney Dis. (IF 3.7) Pub Date : 2022-10-31 Yasser El Miedany, Naglaa Ali Gadallah, Eman Sarhan, Mathias Toth, Mona Mansour Hasab El Naby, Mohamed Elwy, Sahar Ganeb, Maha El Gaafary, Mohamed Mortada, Samah Ismail Nasef, Nevine Mohannad, Safaa Ali Mahran, Mohammed Hassan Abu-Zaid, Mervat Eissa, Waleed Hassan, Basma M Medhat, Rasha Ghaleb, Samar Abdelhamed Tabra, Heba Gamal Saber, Rehab Ali Ibrahim, Sally Saber, Salwa Galal
Objective: The aim of this study was to reach a consensus on an updated version of the recommendations for the diagnosis and Treat-to-Target management of osteoporosis that is effective and safe for individuals with chronic kidney disease (CKD) G4-G5D/kidney transplant. Methods: Delphi process was implemented (3 rounds) to establish a consensus on 10 clinical domains: (1) study targets, (2) risk factors
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KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging Kidney Dis. (IF 3.7) Pub Date : 2022-09-27 Mingsheng Zhu, Xian Ling, Shan Zhou, Ping Meng, Qiyan Chen, Shuangqin Chen, Kunyu Shen, Chao Xie, Yaozhong Kong, Maosheng Wang, Lili Zhou
Introduction: Aged kidney is characterized by mitochondrial dysfunction, cellular senescence, and fibrogenesis. The activation of Wnt/β-catenin signaling plays an important role in the initiation of kidney aging. However, the inhibiting strategies have not been discovered in detail. Here, we compared the therapeutic effects of two β-catenin inhibitors, KYA1797K and ICG-001, to assess their superiority
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The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases Kidney Dis. (IF 3.7) Pub Date : 2022-09-12 Wei Tang, Yufeng Zhang, Sijia Cui, Fan Yi
Background: Kidney diseases are a prevalent health problem worldwide. Although substantial progress has been made in understanding the pathophysiology of kidney disease, currently there is no satisfactory clinical treatment available to prevent or treat kidney disease. Therefore, strategies to establish early diagnosis, identify the key molecules, and develop novel therapeutic interventions to slow
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SENP3 Aggravates Renal Tubular Epithelial Cell Apoptosis in Lipopolysaccharide-Induced Acute Kidney Injury via deSUMOylation of Drp1 Kidney Dis. (IF 3.7) Pub Date : 2022-06-30 Lirui Wang, Jiangtao Li, Chen Yu
Background: Sepsis causes acute kidney injury (AKI) in critically ill patients, although the mechanisms underlying the pathophysiology are not fully understood. SUMO-specific proteases 3 (SENP3), a member of the deSUMOylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, the role of SENP3 in septic AKI remains unclear. Objectives: The purpose
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Should More Patients with Kidney Failure Bring Treatment Home? What We Have Learned from COVID-19 Kidney Dis. (IF 3.7) Pub Date : 2022-06-15 Xueqing Yu, Vivekanand Jha, Hidetomo Nakamoto
Background: The COVID-19 pandemic is challenging healthcare systems worldwide and has placed hospitals and healthcare providers (HCPs) at the center of a global crisis. Disruptions to hospital priorities, and limitations placed on the mobility of societies, have contributed to changes in the way HCPs and patients view and access dialysis for kidney failure, including which dialysis modality is preferred
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Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals Kidney Dis. (IF 3.7) Pub Date : 2022-06-13 Xiangyang Gu, Baoxue Yang
Background: The glomerular filtration rate (GFR), as the benchmark of renal function, has been widely used in clinical practice and basic medical research. Currently, most researchers still rely on endogenous markers, such as plasma creatinine, blood urea nitrogen, and cystatin C, to evaluate renal function in laboratory animals. While inexpensive and simple to use, methods based on endogenous markers
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Association of Immune-Related Genetic and Epigenetic Alterations with Lupus Nephritis Kidney Dis. (IF 3.7) Pub Date : 2022-06-09 Xiaole Mei, Hui Jin, Ming Zhao, Qianjin Lu
Background: The familial clustering phenomenon together with environmental influences indicates the presence of a genetic and epigenetic predisposition to systematic lupus erythematosus (SLE). Interestingly, regarding lupus nephritis (LN), the worst complication of SLE, mortality, and morbidity were not consistent with SLE in relation to sexuality and ethnicity. Summary: Genetic and epigenetic alterations
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suPAR: An Inflammatory Mediator for Kidneys Kidney Dis. (IF 3.7) Pub Date : 2022-06-08 Yashwanth Reddy Sudhini, Changli Wei, Jochen Reiser
Background: Inflammation is a common feature of many kidney diseases. The implicated inflammatory mediators and their underlying molecular mechanisms however are often not clear. Summary: suPAR is the soluble form of urokinase-type plasminogen activator receptor (uPAR), associated with inflammation and immune activation. It has evolved into a unique circulating kidney disease factor over the last 10
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Deep Learning-Based Model Significantly Improves Diagnostic Performance for Assessing Renal Histopathology in Lupus Glomerulonephritis Kidney Dis. (IF 3.7) Pub Date : 2022-06-07 Luping Shen, Wenyi Sun, Qixiang Zhang, Mengru Wei, Huanke Xu, Xuan Luo, Guangji Wang, Fang Zhou
Background: Assessment of glomerular lesions and structures plays an essential role in understanding the pathological diagnosis of glomerulonephritis and prognostic evaluation of many kidney diseases. Renal pathophysiological assessment requires novel high-throughput tools to conduct quantitative, unbiased, and reproducible analyses representing a central readout. Deep learning may be an effective
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Activated Platelets, the Booster of Chronic Kidney Disease and Cardiovascular Complications Kidney Dis. (IF 3.7) Pub Date : 2022-06-03 Shuiqin Gong, Chenyu Wang, Jiachuan Xiong, Jinghong Zhao, Ke Yang
Background: Chronic kidney disease (CKD) has become a global public health problem nowadays. As cardiovascular diseases (CVDs) are the primary cause of death in advanced CKD patients, much attention has been paid to resolving their cardiovascular complications. However, managing CKD and cardiovascular complications is still a big challenge for nephrologists, as satisfactory treatments are still lacking
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Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis Kidney Dis. (IF 3.7) Pub Date : 2022-05-30 Daoyuan Lv, Song Jiang, Mingchao Zhang, Xiaodong Zhu, Fan Yang, Hui Wang, Shen Li, Feng Liu, Caihong Zeng, Weisong Qin, Limin Li, Zhihong Liu
Introduction: Membranous nephropathy (MN) is a common chronic kidney disease in adults and a major challenge of clinical practice for its treatment. Despite major advances, since the discovery of the phospholipase A2 receptor as the major autoantigen of podocytes in MN, the mechanisms leading to glomerular damage remain elusive. Pyroptosis, a newly discovered type of programed necrotic cell death mainly
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Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis Kidney Dis. (IF 3.7) Pub Date : 2022-05-03 Zuoquan Xie, Siyu Tong, Xingkun Chu, Teng Feng, Meiyu Geng
Background: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients. Summary: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment
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Development and Validation of a Prognostic Nomogram to Predict 30-Day Mortality Risk in Patients with Sepsis-Induced Cardiorenal Syndrome Kidney Dis. (IF 3.7) Pub Date : 2022-05-03 Yiguo Liu, Yingying Zhang, Yuqiu Lu, Hao Tian Li, Chen Yu
Introduction: Sepsis-induced cardiorenal syndrome (sepsis-induced CRS) is a devastating medical condition that is frequently associated with a high fatality rate. In this study, we aimed to develop an individualized nomogram that may help clinicians assess 30-day mortality risk in patients diagnosed with sepsis-induced CRS. Methods: A total of 340 patients with sepsis-induced CRS admitted from January
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Extracellular Vesicles That Herald the Scarcity of Oxygen Kidney Dis. (IF 3.7) Pub Date : 2022-04-22 Sekyung Oh, Sang-Ho Kwon
The natural, membrane-bound nanoscale particles, called extracellular vesicles (EVs) have emerged as an effective, versatile vehicle to transport desired drugs specifically to injury sites. Heralding the presence of the scarcity of oxygen, EVs produced from the cells upregulating the expression of the critical transcriptional regulator of hypoxia, HIF-1, can induce a response in ischemia-reperfusion-damaged
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Venous Thromboembolism in Kidney Diseases and Genetic Predisposition Kidney Dis. (IF 3.7) Pub Date : 2022-04-11 Tingting Wu, Liang V. Tang, Yu Hu
Background: Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases. In addition, venous thrombosis, as a complication, has also been reported in a variety of