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Endothelial biomarkers in critically-ill COVID-19 patients: potential predictors of the need for dialysis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-28 Marza de Sousa Zaranza,Gdayllon Cavalcante Meneses,Reinaldo Barreto Oriá,Alice Maria Costa Martins,Natalia Linhares Ponte Aragão,Nilcyeli Linhares Aragão,Saskya Roberta Rodrigues de Andrade,Nicole Coelho Lopes,Letícia Machado de Araújo,Ranieri Sales de Souza Santos,Álvaro Rolim Guimarães,Ana Paula Pires Lázaro,Andrea Mazza Beliero,Márcia Maria Pinheiro Dantas,Sandra Mara Brasileiro Mota,Geraldo Bezerra
INTRODUCTION To evaluate the function of vascular biomarkers to predict need for hemodialysis in critically-ill patients with COVID-19. METHODS This is a prospective study with 58 critically-ill patients due to COVID-19 infection. Laboratory tests in general and vascular biomarkers, such as VCAM-1, Syndecan-1, Angiopoietin-1 and Angiopoeitin-2 were quantified on intensive care unit (ICU) admission
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Clinical features, outcomes, and response to corticosteroid treatment of acute tubulointerstitial nephritis: a single centre retrospective cohort study in Czech Republic. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-27 Oskar Zakiyanov,Yaprak Ḉaḡlar,Romana Ryšavá,Eva Jančová,Dita Maixnerová,Doubravka Frausová,Tomáš Indra,Eva Honsová,Vítězslav Kříha,Ivan Rychlík,Vladimír Tesař,Věra Čertíková Chábová
INTRODUCTION Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, and responses to corticosteroid treatment in patients with ATIN. METHODS Patients with biopsy proven ATIN, who were diagnosed between 1994-2016 at the Department of Nephrology
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The association between dapagliflozin use and the risk of post contrast acute kidney injury in patients with type 2 diabetes and chronic kidney disease: a propensity-matched analysis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-17 Tao Liu,Xinwen Jian,Li Li,Shan Chu,Zeyuan Fan
Introduction This study aimed to investigate the effect of dapagliflozin in preventing post contrast acute kidney injury (PC-AKI) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD) who underwent an elective coronary procedure. Methods Data of patients with T2DM and CKD undergoing an elective coronary procedure at Civil Aviation General Hospital from October 2020 to April 2023
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Bosentan does not affect renal resistive index in scleroderma/systemic sclerosis patients. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-08 Emma Di Poi,GianLuca Colussi,Martina Bertoni,Ivan Giovannini,Barbara Tolusso,Gian Franco Ferraccioli,Elisa Gremese,Salvatore De Vita,Giulio Romano
INTRODUCTION If properly evaluated, chronic kidney disease can be found in up to 50% of patients with systemic sclerosis (SSc). The renal resistive index (RRI) is a marker of intrarenal vascular resistance and can predict SSc-associated vasculopathy. This study aimed to determine the impact of bosentan, a nonselective endothelin-1 receptor antagonist, on RRI and kidney function in SSc patients with
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Salvianolic acid B inhibits oxidative stress in glomerular mesangial cells alleviating diabetic nephropathy by regulating SIRT3/FOXO1 signaling. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-07 Feiying Wen,Shengmiao Zhang,Liqin Sun,Manqing Qian,Haofeng Xu
INTRODUCTION Oxidative stress is pivotal in advancing diabetic nephropathy (DN). Salvianolic acid B (SAB), derived from Radix Salviae miltiorrhizae, exhibits renoprotective effects. However, the mechanisms underlying its action in DN are not fully elucidated. This study explores SAB's protective effect on DN, focusing on its antioxidative properties in glomerular mesangial cells. METHODS The renoprotective
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Characteristics of month-by-month blood pressure variability in patients on hemodialysis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-11-04 Yoshifumi Amari,Satoshi Morimoto,Takatomi Yurugi,Yasuo Oyama,Fumitaka Nakajima,Satoru Shimizu,Atsuhiro Ichihara
INTRODUCTION Poor prognosis in hemodialysis patients is due to the increased prevalence of cardiovascular diseases among them. We previously reported that higher visit-by-visit blood pressure variability is associated with increased cardiovascular mortality in hemodialysis patients. This present study aimed to investigate the characteristics of month-by-month blood pressure variability in these patients
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Electronic acute kidney injury alert at the Brandenburg Medical School - implementation and follow-up. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-10-28 Alicia Assem,Wajima Safi,Oliver Ritter,Daniel Patschan
Introduction Acute kidney injury (AKI) substantially worsens the prognosis of hospitalized patients world-wide. In order to optimize early AKI recognition and therapeutic intervention, AKI alert systems have been implemented and evaluated in the past. Herein, we aimed to analyze outcome var-iables of AKI patients under the conditions of a de-novo-established AKI alert system at the Brandenburg Hospital
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Effects of Aliskiren Monotherapy versus Amlodipine Monotherapy in Hypertensive Patients with Obesity or Type 2 Diabetes Mellitus. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-10-20 Yasufumi Seki,Satoshi Morimoto,Shihori Kimura,Noriyoshi Takano,Kaoru Yamashita,Kanako Bokuda,Nobukazu Sasaki,Daisuke Watanabe,Atsuhiro Ichihara
INTRODUCTION Renin-angiotensin system inhibitors have been reported to exert protective effects against organ damage and failure; however, the impact of direct renin inhibitor as monotherapy has not been assessed. Here we investigated the effects of 24-week monotherapy with aliskiren compared to amlodipine in hypertensive patients with type 2 diabetes or obesity. METHODS In this randomized intervention
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Blood pressure and Mortality in the 4D Study. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-10-07 Babak Yazdani,Marcus E Kleber,Graciela E Delgado,Gökhan Yücel,Aruscha Asgari,Andreas L H Gerken,Clara Daschner,Niklas Ayasse,Winfried März,Christoph Wanner,Bernhard K Krämer
INTRODUCTION Systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP) are risk factors for cardiovascular mortality (CVM). Pulse pressure (PP) is an easily available parameter of vascular stiffness, but its impact on CVM in chronic dialysis patients with diabetes is unclear. METHODS Therefore, we have examined the predictive value of baseline, predialytic PP, SBP, DBP and MAP in the German
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Proteomics to metabolomics: A new insight into the pathogenesis of hypertensive nephropathy. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-10-04 Yasin Eshraghi,Maryam Abedi,Yousof Gheisari
BACKGROUND Hypertensive nephropathy (HN) is a high burden disorder and a leading cause of end-stage renal disorder. In spite of huge investigations, the underlying mechanisms are yet largely unknown. Systems biology is a promising approach to provide a comprehensive insight towards this complex disorder. METHODS Protein expression profiles of kidney tubule and cortex sub-compartments were retrieved
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APOL 1 gene variants and risk for cardiovascular disease. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-29 Carlos Eduardo Duran,Mayra Estacio,Daniela Espinosa,Eliana Manzi,Juan G Posada,Liliana Mesa,Johanna Schweineberg
INTRODUCTION The association of APOL1 risk variants with cardiovascular risk and cardiovascular disease in observational and clinical trials has had inconsistent results. We aim to assess the relationship between the presence of APOL1 risk variants and the CVD risk in Afro-descendant patients with end-stage renal disease (ESRD). METHODS We performed an observational, cross-sectional study of Afro-descendant
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PLA2G12B mediates arachidonic acid metabolism through activation of the NF-κB pathway to promote membrane nephropathy. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-27 Linlin Fu,Jinliang Ping,Fei Guo,Jiafeng Song,Mingjun Luo,Lijing Chen
INTRODUCTION The disruption of podocytes structure and function are the main pathological mechanism of membranous nephropathy (MN). Phospholipases A2, Group XII B (PLA2G12B) was reported involved in the regulation of MN by interfering with arachidonic acid (AA) metabolism, but there is a lack of sufficient evidence. In this study, we investigated the role and molecular mechanism of PLA2G12B in MN.
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Risk factors and drug efficacy for severe illness in hemodialysis patients infected with the Omicron variant of COVID-19. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-26 Yan Wu,Lingling He,Yongping Guo,Niansong Wang
BACKGROUND The Omicron variant of the novel coronavirus (COVID-19) has been spreading more rapidly and is more infectious, posing a higher risk of death and treatment difficulty for patients undergoing hemodialysis. This study aims to explore the severity rate and risk factors for hemodialysis patients infected with the Omicron variant, and to conduct a preliminary analysis of the clinical efficacy
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Acute kidney injury and rehabilitation outcomes among elderly patients with chronic kidney disease. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-22 Naomi Nacasch,Erez Sarel,Ilan Rozenberg,Rachel Heffez Ayzenfeld,Meidad Greenberg,Daniel Erez,Sydney Benchetrit,Keren Cohen-Hagai
INTRODUCTION As the geriatric population rapidly grows, so does the incidence of chronic kidney disease (CKD). CKD patients have higher incidence of fractures, stroke and hospitalizations requiring rehabilitation along with the need for suitable rehabilitation programs to decrease disability and improve functionality to maintain independence in activities of daily life of elderly CKD patients. Considering
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A role for sodium-glucose cotransporter 2 inhibitors in the treatment of chronic kidney disease - A mini review. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-16 Jinfang Song,Xia Li,Jiang Ni
BACKGROUND Sodium glucose cotransport protein 2 (SGLT2) inhibitors, a new type of glucose-lowering drug, have been well proved in several clinical studies for their glucose-lowering and nephroprotective effects, and the nephroprotective effects include both indirect effects of metabolic improvement and direct effects independent of glucose-lowering effects. SUMMARY In patients with diabetic kidney
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Transcription factor Sox9 exacerbates kidney injury through inhibition of microRNA-96-5p and activation of the Trib3/IL-6 axis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-16 Xiao Wang,Guang Chen,Yongqiang Du,Jiajia Yang,Wei Wang
INTRODUCTION Our study investigated the possible mechanisms of the role of the transcription factor Sox9 in the development and progression of kidney injury through regulation of the miR-96-5p/Trib3/IL-6 axis. METHODS Bioinformatics analysis was performed to identify differentially expressed genes in kidney injury and normal tissues. An in vivo animal model of kidney injury and an in vitro cellular
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Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-15 Ting Zhou,Shiyuan Wang,Yajing Pan,Xingtong Dong,Leiyun Wu,Jiali Meng,Jialing Zhang,Qi Pang,Aihua Zhang
INTRODUCTION Protein-energy waste (PEW) is a common complication in patients with chronic kidney disease (CKD), among which skeletal muscle atrophy is one of the most important clinical features of PEW. Pyroptosis is a type of proinflammatory programmed cell death associated with skeletal muscle disease. Irisin, as a novel myokine, has attracted extensive attention for its protective role in the complications
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Estimation of glomerular filtration rate (eGFR) - Implicit Racism in Medicine and Medical Education? Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-09-07 Amy R Lorber,Christine Schmitt,Kaitlyn VanRiper,Shibani Kanungo
As we seek to understand the use of race in medicine, it is necessary to revisit our history. The fact that slavery was a crucial driver of economic expansion of the early U.S. colonies created social need to justify the subjugation of enslaved peoples. Race is a social construct, rather than a biological one. Medical education teaches that race is as a "risk factor," often used as a proxy for other
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Cognitive impairment and anxiety are prevalent in kidney transplant recipients. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-08-24 Aleksandra Golenia,Piotr Olejnik,Norbert Żołek,Ewa Wojtaszek,Jolanta Małyszko
INTRODUCTION Cognitive impairment (CI) is common in end-stage kidney disease (ESKD), including kidney transplant recipients. Patients with cognitive problems may find it difficult to comply with medical recommendations after kidney transplantation (KT), which can be the cause of many complications, poorer prognosis, and increased hospitalization rates after transplantation. Additionally, some patients
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Childhood-onset Refractory Hypertension Results from Neurofibromatosis type 1 Caused by a Splicing NF1 mutation. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-08-10 Yi-Ting Lu,Buweimairemu Rejiepu,Di Zhang,Dong-Cheng Cai,Kun-Qi Yang,Tao Tian,Xian-Liang Zhou,Peng Fan
BACKGROUND Neurofibromatosis type 1 (NF-1) is caused by mutations in the NF1 gene that encodes neurofibromin, a negative regulator of RAS proto-oncogene. Approximately one-third of the reported pathogenic mutations in NF1 are splicing mutations, but most consequences are unclear. The objective of this study was to identify the pathogenicity of splicing mutation in a Chinese family with NF-1 and determine
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Systolic blood pressure and the risk of kidney replacement therapy and mortality in patients with chronic kidney disease stage 4-5. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-08-05 Jonathan S Chávez-Iñiguez,Jose J Zaragoza,Jahir R Camacho-Guerrero,Vanessa Villavicencio-Cerón,Rafael Valdez-Ortiz,Ana E Huerta-Orozco,Gael Chávez-Alonso,Ana E Oliva-Martinez,Bladimir Díaz-Villavicencio,Clementina E Calderón-García,Jose D González-Barajas,Manuel Arizaga-Nápoles,Frida M De La Vega-Méndez,Juan A Gómez-Fregoso,Francisco G Rodríguez-García,Guillermo Navarro-Blackaller,Ramón Medina-González
Introduction In patients with chronic kidney disease stage 4 and 5 (CKD stages 4-5) without dialysis and arterial hypertension, it is unknown if the values of systolic blood pressure (SBP) considered in control <120 mmHg are associated with kidney replacement therapy (KRT) and mortality. Methods In this retrospective cohort study, hypertensive CKD stages 4-5 patients attending the Renal Health Clinic
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Left Main Coronary Artery Revascularization in Patients with Impaired Renal Function; Percutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-07-28 Amin Daoulah,Rasha Taha Baqais,Alwaleed Aljohar,Abdulkarim Alhassoun,Ahmad S Hersi,Wael Almahmeed,Nooraldaem Yousif,Abdulaziz Alasmari,Mohammed Alshehri,Fakhreldein Eltaieb,Badr Alzahrani,Ahmed Elmahrouk,Amr A Arafat,Ahmed Jamjoom,Khalid Z Alshali,Reda Abuelatta,Waleed A Ahmed,Abdulrahman H Alqahtani,Turki Al Garni,Shahrukh Hashmani,Ziad Dahdouh,Wael Refaat,Hameedullah M Kazim,Mohamed Ajaz Ghani,Haitham
INTRODUCTION The evidence about the optimal revascularization strategy in patients with left-main coronary artery (LMCA) disease and impaired renal function is limited. Thus, we aimed to compare the outcomes of LMCA disease revascularization (PCI vs. CABG) in patients with and without impaired renal function. METHODS This retrospective cohort study included 2138 patients recruited from 14 centers between
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Application Value of Limb Ischemic Preconditioning in Preventing Intradialytic Hypotension during Maintenance Hemodialysis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-07-27 Yaqin Mao,Linfang Xu,Juntian Xu,Yushang Tang,Tongqiang Liu
OBJECTIVE To investigate the efficacy and safety of limb ischemia preconditioning (LIPC) in the treatment of intradialytic hypotension (IDH) in patients with maintenance hemodialysis (MHD). METHODS This was a single-center, prospective and randomized controlled case study. A total of 38 patients with MHD who met the inclusion criteria from September 2021 to August 2022 were selected from the Blood
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Identification of PDK4 as hub gene for diabetic nephropathy using co-expression network analysis. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-29 Yuanyuan Han,Liangzi Jin,Liangzhi Wang,Lan Wei,Chao Tu
INTRODUCTION Diabetic nephropathy (DN) is related to type 1 and type 2 diabetes. They are the leading cause of end-stage renal disease (ESRD), but the underling specific pathogenesis of DN is not yet clear. Our study was conducted to explore how DN changed the transcriptome profiles in kidney. METHODS The gene expression profile of micro-dissected glomeruli of 41 type 2 diabetic nephropathy patients
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Urinary N-Terminal Pro-Brain Natriuretic Peptide Predicts Acute Kidney Injury and Severe Disease in COVID-19. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-26 Manuel Julian Vogel,Simon B Leininger,Stephan T Staudner,Ute Hubauer,Stefan Wallner,Julian Mustroph,Frank Hanses,Markus Zimmermann,Petra Lehn,Ralph Burkhardt,Lars S Maier,Julian Hupf,Carsten G Jungbauer
INTRODUCTION The ongoing COVID-19 pandemic is placing an extraordinary burden on our health care system with its limited resources. Accurate triage of patients is necessary to ensure medical care for those most severely affected. In this regard, biomarkers could contribute to risk evaluation. The aim of this prospective observational clinical study was to assess the relationship between urinary N-terminal
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Incidence and factors associated with uncontrolled hypertension at 12 months after kidney transplantation in Saudi Arabia. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-23 Ziad Arabi,Nader Fawzy,Tarek Arabi,Belal Sabbah,Hamzah Alhamzah,Fayez Alhejaili
INTRODUCTION Uncontrolled hypertension after kidney transplantation (KTx) is very common and is associated with significant morbidity. However, studies that assess its incidence and risk factors are limited and outdated in the Middle East. METHODS This is a single-center retrospective study of KTx recipients (KTRs) in our center between January 2017 and May 2020 with a 12-month follow-up period. The
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Histopathological features of time-zero kidney biopsy are predictive factors for posttransplant anemia. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-12 Mislav Mokos,Ivana Juric,Ivica Mokos,Marijana Coric,Zeljko Kastelan,Nikolina Basic-Jukic
Posttransplant anemia is a common complication of kidney transplantation, associated with reduced graft survival and higher mortality. We aimed to determine the association of posttransplant anemia with histopathological characteristics of time-zero allograft biopsy and donor clinical characteristics. Methods We conducted a retrospective, observational cohort study that included 587 patients who underwent
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LncRNA PMS2L2 is downregulated in sepsis-induce acute kidney injury and inhibits LPS-induced apoptosis of podocytes. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-07 Fengxiang Zhang,Xigang Luo,Yi Wang,Lingling Ma,Dapeng Sun
BACKGROUND Long non-coding RNA (lncRNA) PMS2L2 can inhibit inflammation induced by LPS, while LPS plays an important role in sepsis, indicating the possible involvement of PMS2L2 in sepsis. METHODS Expressions of miR-21 and PMS2L2 in patients with acute kidney injury (AKI), sepsis patients without AKI induced and healthy controls was determined by performing RT-qPCR. Overexpression assay was performed
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Casual serum triglyceride concentrations and new-onset chronic kidney disease in the general Japanese population: the Iki city epidemiological study of atherosclerosis and chronic kidney disease study. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-06 Koji Takahashi,Yoshihiro Nishida,Soichiro Yokota,Kazuhiro Tada,Hiroto Hiyamuta,Kenji Ito,Tetsuhiko Yasuno,Tosihki Maeda,Hisatomi Arima,Kosuke Masutani
INTRODUCTION Non-fasting triglyceride (TG) concentrations are useful for predicting various diseases, but most epidemiological studies investigated the association between fasting TG concentrations and chronic kidney disease (CKD). This study aimed to examine the association between casual (fasting or non-fasting) serum TG concentrations and new-onset CKD in the general Japanese population. METHODS
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Prediction of CKD progression and cardiovascular events using albuminuria and pulse wave velocity. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-06 Rasmus Kirkeskov Carlsen,Dinah Sherzad Khatir,Danny Jensen,Henrik Birn,Niels Henrik Buus
INTRODUCTION Chronic kidney disease (CKD) is associated with cardiovascular disease (CVD) and death. Albuminuria is an established risk factor, but additional biomarkers predicting CKD progression or CVD are needed. Arterial stiffness is an easily measurable parameter that has been associated with CVD and mortality. We evaluated the ability of carotid-femoral pulse wave velocity (PWV) and urine albumin-creatinine
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Acute kidney injury after multiple cycles of cisplatin chemotherapy: A nomogram for risk assessment. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-06-06 Xuejing Zhu,Juanjuan Li,Yushang Tang,Xiaoping Li,Juntian Xu,Ran Jing,Tongqiang Liu
BACKGROUND Acute kidney injury (AKI) caused by cisplatin is common and has a higher incidence of multiple use, resulting in a poor short- and long-term prognosis for patients. There is currently no good pre-medication AKI risk assessment tool. The aim of this study is to establish an AKI risk assessment nomogram for patients with multiple cisplatin applications. METHODS This study was a retrospective
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Relationship between dialysate bicarbonate concentration and all-cause mortality in hemodialysis patients. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-05-30 Jingfang Wan,Jing Lin,Weidong Wang,Lili Fu,Weiwei Zhang,Jun Liu,Yang Xiang,Jia Chen,Yani He,Kehong Chen
INTRODUCTION The optimal dialysate bicarbonate concentration (DBIC) for hemodialysis (HD) remains controversial. Herein, we analyzed the effect of dialysate bicarbonate levels on mortality in hemodialysis patients. METHODS Patients undergoing maintenance hemodialysis were recruited from the hemodialysis unit of the Daping Hospital. Patients were categorized into quartiles according to their DBIC level
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The Clinical Manifestation of Immunosuppressive Therapy as a Tool to Improve Immune Monitoring in Renal Transplant Recipients. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-05-25 Noa Scott,Aharon Bendavid,Yana Davidov,Keren Cohen-Hagai,Renana Yemini,Ronen Ghinea,Eytan Mor,Tammy Hod
INTRODUCTION Metrics for post-transplant immune monitoring to prevent over or under immunosuppression in renal transplant recipients (RTRs) are lacking. METHODS We surveyed 132 RTRs, 38 in the first year post transplant and 94 >1 year post-transplant, to study the clinical expression of immunosuppressive therapy. A questionnaire administered to these RTRs was divided into physical (Q physical) and
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CMKLR1 antagonist alpha-NETA protects against diabetic nephropathy in mice. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-05-10 Zining Peng,Xueyi Wang,Qing Zhu,Huili Wang,Bing Li,Xinxin Pang,Jiarui Han
INTRODUCTION Diabetic nephropathy (DN) is a common complication in diabetic patients. Chemerin, a novel adipokine, has been associated with renal damage in DN. The chemerin chemokine-like receptor 1 (CMKLR1) has been reported to participate in DN. In this study, we aimed to investigate the effect of a CMKLR1 antagonist, 2-(anaphthoyl)ethyltrimethylammonium iodide (α-NETA), on DN. METHODS To induce
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Green dialysis – let us talk about dialysis fluid. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-25 Jacek Zawierucha, Wojciech Marcinkowski, Tomasz Prystacki, Jacek S. Malyszko, Michal Pyrza, Pawel Zebrowski, Jolanta Malyszko
Background: Hemodialysis is one of the most resources consuming medical intervention. Due to its concept, the proper amount of dialysis fluid passed through dialyser is crucial to obtain the expected outcomes. The most frequent source of dialysis fluid is production from liquid concentrate (delivered in containers or plastic bags) in dialysis machine. Alternatively, concentrates for dialysis may be
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Relationship between serial serum neutrophil-lymphocyte ratio, cardiovascular mortality, and all-cause mortality in Chinese peritoneal dialysis patients Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-25 Lik Fung Sam Lau, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Phyllis Mei-Shan Cheng, Kai-Ming Chow, Chi-Bon LEUNG, Philip Kam-To Li, Cheuk-Chun Szeto
Background It is believed that the excessive cardiovascular (CV) burden of patients on peritoneal dialysis (PD) is closely associated with chronic inflammation. Neutrophil-lymphocyte ratio (NLR) is an inflammatory marker that was shown to correlate with CV outcomes. However, little is known about the significance of serial monitoring of serum NLR. We aimed to determine the prognostic value of serial
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Unveiling the Unexpected: Why Doctors Should Look Beyond the Lungs When Predicting COVID-19 Mortality Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-25 Eli Zolotov, Anat Sigal, Martin Havrda, Maria Raskova, David Girsa, Uri Hochfeld, Karolína Krátká, Ivan Rychlík
Introduction: The main objective of this study was to identify the best combination of admission day parameters for predicting COVID-19 mortality in hospitalized patients. Furthermore, we sought to compare the predictive capacity of pulmonary parameters to that of renal parameters for mortality from COVID-19. Methods: In this retrospective study, all patients admitted to a tertiary hospital between
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Single-cell transcriptome sequencing reveals molecular mechanisms of renal injury in essential hypertension Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-14 Yige Huyan, Chunyue Wang, Hongen Kang, Xiao Chen, Yuan Chang, Sheng Liu, Jiangping Song
Introduction: Hypertensive nephropathy is characterized by glomerular and tubulointerstitial damage, but we know little about changes in cell-specific gene expression in the early stages of hypertensive kidney injury, which usually has no obvious pathological changes. Methods: We performed unbiased single-cell RNA sequencing of rat kidney samples from hypertensive kidney injury to generate 10602 single-cell
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Polymorphisms of CARD9 Gene Predict Disease Progression and Renal Survival of Immunoglobulin A Nephropathy Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-14 Chunhong He, Dianchun Shi, Lin Guo, Zhong Zhong, Xue-Qing Yu, Ming Li
Introduction: A previous genome-wide association study has identified CARD9 (caspase recruitment domain family member 9) as a susceptibility gene for Immunoglobulin A nephropathy (IgAN), which encodes an adapter protein and is related to mucosal immunity. This study aims to investigate the association of CARD9 variants with the clinicopathological phenotypes and prognosis of IgAN. Methods: Eight SNPs
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Clinicopathological Characteristics and Outcomes of Immunoglobulin A Nephropathy with Different Types of Dyslipidemia: A Retrospective Single-Center Study Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-14 Sidi Liu, Zhenzhen Lu, Zhike Fu, Huijie Li, Chuying Gui, Yueyi Deng
Introduction: Immunoglobulin A nephropathy (IgAN) is one of the most common glomerulonephritic diseases in the world. Several lines of evidence have suggested that dyslipidemia is related to the disease progression and prognosis of IgAN. However, the study is scarce on the clinicopathological characteristics and outcomes of IgAN with dyslipidemia. Methods: This study retrospectively analyzed 234 patients
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Vitamin D ameliorates podocyte injury by enhancing autophagy activity in diabetic kidney disease Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-13 Xiaoyi Zhang, Li Zhang, Yingzhen Wen, Mengxian Zhang, Shuangxin Liu, Houqin Xiao
Introduction: Restoration of podocyte autophagy is considered as a feasible strategy for the treatment of diabetic kidney disease (DKD). This study aimed at investigating the protective effect and potential mechanism of vitamin D on podocyte injury of DKD. Methods: Type 2 diabetic db/db mice received intraperitoneal injections of vitamin D analogue paricalcitol 400ng/kg per day for 16 weeks. Immortalized
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Identification the genetic influence of SARS-CoV-2 infections on IgA nephropathy based on bioinformatics method. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-11 Xiaoqi Deng, Yu Luo, Tianjun Guan, Xiaodan Guo
Introduction: Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. It was initially detected in Wuhan, China, in December 2019. In March 2020, the World Health Organization (WHO) declared COVID-19 a global pandemic. Compared to healthy individuals, patients with IgA nephropathy (IgAN) are at a higher risk of SARS-CoV-2 infection. However
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The long-term survival outcome in older patients with different pathological types of chronic kidney disease Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-11 Feng Yu, Ganyuan He, Wen-ke Hao, Wenxue Hu
Introduction: Chronic kidney diseases (CKD) are prevalent in older people and renal pathological manifestations are important for diagnosis, treatment and prognosis. However, the long-term survival outcome and risk factors for older CKD patients with different pathological types are not fully understood and need to be further investigated. Methods: Medical data were recorded and all-cause mortality
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Novel metabolites to improve glomerular filtration rate estimation Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-10 Xinghua Guo, Hongquan Peng, Peijia Liu, Leile Tang, Jia Fang, ChiWa AoIeong, Tou Tou, Tsungyang Tsai, Xun Liu
Introduction: The glomerular filtration rate (GFR) is crucial for chronic kidney disease (CKD) diagnosis and therapy. Various studies have sought to recognize ideal endogenous markers to improve the estimated GFR (eGFR) for clinical practice. To screen out potential novel metabolites related to GFR (mGFR) measurement in CKD patients from the Chinese population, we identified more biomarkers for improving
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Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-05 Tsuneo Takenaka, Arif Hasan, Takeshi Marumo, Tsutomu Inoue, Takashi Miyazaki, Hiromichi Suzuki, Yoshifumi Kurosaki, Naohito Ishii, Akira Nishiyama, Matsuhiko Hayashi
Introduction: While recent investigations show that klotho exerts reno-protective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage. Methods: The impacts of subcutaneous klotho supplementation on rats with subtotal nephrectomy were examined. Animals were divided into 3 groups: group1 (short remnant, SR): remnant kidney for 4 weeks, group 2 (long remnant
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Methodology and Baseline Data of a Comparative Exploratory Double-Blinded Randomized Study of Intravenous Iron on Fibroblast Growth Factor 23 and Phosphate in Chronic Kidney Disease Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-04 Xenophon Kassianides, Sunil Bhandari
Modern intravenous iron compounds (e.g., ferric carboxymaltose [FCM] and ferric derisomaltose [FDI]) are utilized in the treatment of iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD). Product-specific alterations in the metabolism of fibroblast growth factor 23 (FGF-23) leading to hypophosphatemia have been described for certain intravenous iron compounds, such as FCM
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International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-04-04 Stefanie Thöni, Felix Keller, Sara Denicolò, Susanne Eder, Lukas Buchwinkler, László Rosivall, Andrzej Wiecek, Patrick Barry Mark, Peter Rossing, Hiddo L. Heerspink, Gert Mayer
Introduction: Type 2 diabetes and its complications represent a huge burden to public health. With this prospective, observational cohort study, we aimed to estimate and to compare the incidence rate (IR) of renal and cardiovascular outcomes and all-cause mortality in patients with type 2 diabetes in different European countries. Methods: The renal endpoint was a composite of a sustained decline in
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Increased plasma homocysteine levels are associated with left ventricular hypertrophy in hypertensive patients with normal renal function. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-30 Lingyu Zhang, Tingjun Wang, Yihua Shen, Li Luo, Guoyan Xu, Liangdi Xie
Introduction: Renal function has an important bearing on plasma homocysteine levels. Plasma homocysteine is related to left ventricular hypertrophy (LVH). However, it remains unclear whether the association between plasma homocysteine levels and LVH is influenced by renal function. This study aimed to investigate relationships among left ventricular mass index (LVMI), plasma homocysteine levels and
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Urea reduction in acute kidney injury and mortality risk Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-27
Introduction Urea is a toxin present in acute kidney injury (AKI). We hypothesize that reduction in serum urea levels might improve clinical outcomes. We examined the association between the reduction in urea and mortality. Methods Patients with AKI admitted to the Hospital Civil de Guadalajara were enrolled in this retrospective cohort study. We create 4 groups of urea reduction (UXR) stratified by
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Corticosteroid therapy in IgA Nephropathy: A friend or foe? Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-27 Dana Kim, Muh Geot Wong
Background: The administration of corticosteroids in addition to supportive care to delay progressive Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis worldwide, remains controversial. This is partly due to the paucity of well-designed randomized controlled trials and well-known corticosteroid-related side effects. As a result, clinical equipoise in corticosteroid therapy
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Urea reduction in acute kidney injury and mortality risk. Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-27 Jonathan S Chávez-Íñiguez,Pablo Maggiani-Aguilera,David González-Barajas,Lilia Rizo-Topete,Pablo Galindo,Brian Rifkin,Gael Chávez-Alonso,Alma I Martínez-Aguilar,Sandra Cristina Pérez-Hernández,Karla Hernández-Morales,Jahir R Camacho-Guerrero,Miguel A Pérez-Venegas,Alexa N Oseguera-González,Cesar Murguia-Soto,Guillermo Navarro-Blackaller,Ramón Medina-González,Maria de la Luz Alcantar-Vallin,Karina Renoirte-López
Introduction Urea is a toxin present in acute kidney injury (AKI). We hypothesize that reduction in serum urea levels might improve clinical outcomes. We examined the association between the reduction in urea and mortality. Methods Patients with AKI admitted to the Hospital Civil de Guadalajara were enrolled in this retrospective cohort study. We create 4 groups of urea reduction (UXR) stratified by
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Intra-renal and urinary glycogen synthase kinase 3 beta levels in diabetic and non-diabetic chronic kidney disease Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-20 Lingfeng Zeng, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto
Background Renal glycogen synthase kinase-3 beta (GSK3β) over-activity has been associated with a diverse range of kidney diseases. GSK3β activity in urinary exfoliated cells was reported to predict the progression of diabetic kidney disease (DKD). We compared the prognostic value of urinary and intra-renal GSK3β levels in DKD and non-diabetic chronic kidney disease (CKD). Methods We recruited 118
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Optimal renal artery-aorta angulation revealed by flow simulation Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-20 David Csonka, Károly Kalmár Nagy, Péter Szakály, Sándor Szukits, Péter Bogner, Akos Koller, Szilárd Kun, István Wittmann, István Ervin Háber, Iván Gabor Horváth
Introduction In blood circulation, the vessel branching angle may have hemodynamic consequences. We hypothesized that there is a hemodynamically optimal range for the renal artery branching angle. Methods Posttransplant kinetics of eGFR (estimated glomerular filtration rate) data were analyzed regarding the donor and implant sides (right-to-right, left-to-right position) (n=46). The renal artery branching
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Prevalence of cognitive impairment in peritoneal dialysis patients and associated factors Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-20 Aleksandra Golenia, Norbert Zolek, Piotr Olejnik, Ewa Wojtaszek, Tomasz Glogowski, Jolanta Malyszko
Background. Cognitive impairment (CI) in patients with chronic kidney disease, including those treated with renal replacement therapy (RRT) is a growing problem worldwide. The study aimed to assess the prevalence of CI and associated factors in patients undergoing peritoneal dialysis (PD). Methods. In this cross-sectional study, 18 consecutive patients with PD therapy and 15 controls were evaluated
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Measurement of complement activation via plasma soluble C5b-9 comparison with terminal complement complex staining in a series of kidney biopsies Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-14 Carolyn Wijaya, Christine Burns, Sharron Hall, Melissa Farmer, Denise Jones, Matthew Rowlandson, Peter Choi, Mark Formby, Theo de Malmanche
Introduction: With the emergence of therapeutic complement inhibitors, there is a need to identify patients with complement-driven inflammation. C5b-9 is the terminal product of the three complement pathways, and therefore a marker of total complement activation. We present a pilot study which aims to assess whether plasma soluble C5b-9 (sC5b-9) correlates with terminal complement complex (TCC) staining
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Measurement of complement activation via plasma soluble C5b-9 comparison with terminal complement complex staining in a series of kidney biopsies Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-14
Introduction: With the emergence of therapeutic complement inhibitors, there is a need to identify patients with complement-driven inflammation. C5b-9 is the terminal product of the three complement pathways, and therefore a marker of total complement activation. We present a pilot study which aims to assess whether plasma soluble C5b-9 (sC5b-9) correlates with terminal complement complex (TCC) staining
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Serum 25(OH)D level is negatively associated with fatigue in elderly maintenance hemodialysis patients Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-07
Introduction: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is frequently observed in maintenance hemodialysis (MHD) patients, and is associated with fracture, muscle weakness, malnutrition, etc.; however, relationships of CKD-MBD markers and fatigue are not well established. Methods: This was a cross-sectional study included 244 MHD patients (89 elders) from July to September 2021 in
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Aberrant Gut Microbiome Contributes to Barrier Dysfunction, Inflammation and Local Immune Responses in IgA Nephropathy Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-06 Yuyan Tang, Yong Xiao, Haidong He, Yifan Zhu, Weiqian Sun, Ping Hu, Xudong Xu, Zhen Liu, Zhaowei Yan, Minggang Wei
Introduction Numerous research have shown that serum Gal-deficient (Gd)-IgA1 levels are increased in IgA nephropathy (IgAN) patients and these levels are a dangerous risk factor for IgAN.It has been reported that a relationship between the gut microbiota and IgAN.Whether the gut microbiota participates in the pathogenesis of IgAN was still controversial. Methods We evaluated changes in the gut flora
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Serum 25(OH)D level is negatively associated with fatigue in elderly maintenance hemodialysis patients Kidney Blood Press Res. (IF 2.8) Pub Date : 2023-03-07
Introduction: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is frequently observed in maintenance hemodialysis (MHD) patients, and is associated with fracture, muscle weakness, malnutrition, etc.; however, relationships of CKD-MBD markers and fatigue are not well established. Methods: This was a cross-sectional study included 244 MHD patients (89 elders) from July to September 2021 in