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Systemic Amyloidosis and Kidney Transplantation: An Update Semin. Nephrol. (IF 3.3) Pub Date : 2024-03-14 Shankara K. Anand MS, Vaishali Sanchorawala MD, Ashish Verma MBBS
Amyloidosis is a heterogeneous disorder characterized by abnormal protein aggregate deposition that often leads to kidney involvement and end-stage kidney disease. With advancements in diagnostic techniques and treatment options, the prevalence of patients with amyloidosis requiring chronic dialysis has increased. Kidney transplantation is a promising avenue for extending survival and enhancing quality
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Kidney Transplantation in Multiple Myeloma and Monoclonal Gammopathy of Renal Significance Semin. Nephrol. (IF 3.3) Pub Date : 2024-03-13 Nelson Leung MD, Cihan Heybeli MD
Recent advances in the treatment of plasma cell disorders (PCDs) have provided a wealth of therapy alternatives and improved overall survival tremendously. Various types of PCDs are associated with kidney injury and end-stage kidney disease in a considerable number of patients. Kidney transplantation (KTx) is the best option for renal replacement therapy in select patients in terms of both quality
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Introduction: Clinical Innovations in Transplant Onconephrology Semin. Nephrol. (IF 3.3) Pub Date : 2024-03-11 Naoka Murakami MD PhD, Germaine Wong MD PhD
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Urinary Tract Infection Prevention and Treatment Semin. Nephrol. (IF 3.3) Pub Date : 2024-02-24 Sunita Bavanandan, Niakhaleen Keita
Urinary tract infections are the most common bacterial infections encountered by health care professionals. In women, the lifetime incidence of urinary tract infections may be up to 40% to 50%, of whom a further 40% may have recurrent infections. Urinary tract infections are associated with significant morbidity and potential mortality—they may be complicated by frequent recurrences, kidney damage
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Diagnosis, Prevention, and Treatment of Infections in Kidney Transplantation Semin. Nephrol. (IF 3.3) Pub Date : 2024-02-19 Joyita Bharati, Urmila Anandh, Camille N. Kotton, Thomas Mueller, Aakash K. Shingada, Raja Ramachandran
Kidney transplant often is complicated by infections in the recipient from therapy-related and patient-related risk factors. Infections in kidney transplant recipients are associated with increased morbidity, mortality, and allograft dysfunction. There is a predictable timeline after kidney transplant regarding the types of pathogens causing infections, reflecting the net state of immunosuppression
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Laboratory Monitoring of Heparin Anticoagulation in Hemodialysis: Rationale and Strategies Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-30 Thita Chiasakul, François Mullier, Thomas Lecompte, Philippe Nguyen, Adam Cuker
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are commonly used to prevent clotting of the hemodialysis extracorporeal circuit and optimize hemodialysis adequacy. There is no consensus on the optimal dosing for UFH and LMWHs during hemodialysis. In clinical practice, semiquantitative clotting scoring of the dialyzer and venous chamber may help to guide UFH and LMWH dose adjustment
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Factor XI Inhibitors: Potential Role in End-Stage Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-24 Matthew Ades, Camille Simard, Thomas Vanassche, Peter Verhamme, John Eikelboom, Thomas A. Mavrakanas
Patients with end-stage kidney disease (ESKD) experience a high thrombotic risk but are also at increased risk of bleeding. There is an unmet need for safer antithrombotic therapy in patients with ESKD on hemodialysis. Factor XI (FXI) represents an attractive therapeutic target for anticoagulation because of the potential to mitigate the bleeding risks associated with currently approved anticoagulants
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Detection and Scoring of Extracorporeal Circuit Clotting During Hemodialysis Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-24 Floris Vanommeslaeghe, Wim Van Biesen, Karlien François
Maintaining patency of the extracorporeal hemodialysis (HD) circuit is a prerequisite to perform HD. Unfractionated heparin and low-molecular-weight heparins are the most used anticoagulants in maintenance HD, but their administration comes with a major trade-off of bleeding complications. This narrative review article discusses technical factors impacting on HD circuit patency, such as tubings, dialyzer
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How to Ensure Patency of the Extracorporeal Circuit in Hemodialysis: Global Perspectives Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-24 Alba Santos, Almudena Vega, Andrew Davenport
An adequate knowledge of anticoagulants used to prevent clotting in the extracorporeal circuit is crucial to provide optimal hemodialysis. Drugs can potentially prevent extracorporeal circuit clotting, but administration, half-life, and potential side effects differ. However, there is a lack of concise recommendations to guide anticoagulation and to avoid side effects. Because of the development of
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Clotting Propensity of Surface-Treated Membranes in a Hemodialysis Set-up That Avoids Systemic Anticoagulation Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-23 Hideki Kawanishi, Masahide Koremoto, Casper F.M. Franssen, Marco van Londen
The development of biocompatible membranes, aiming to limit the inflammatory response, oxidative stress, and coagulability during hemodialysis, has been an important step in reducing dialysis-related adverse outcomes. This includes a reduction in the risk of clotting of the extracorporeal circuit, thus enabling hemodialysis with a reduced dose or even without systemic anticoagulant drugs in patients
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Infection-Related Glomerulonephritis in Children and Adults Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-19 Arpana Iyengar, Nivedita Kamath, Jai Radhakrishnan, Blanca Tarragon Estebanez
Infection-related glomerulonephritis is an immunologically mediated glomerular injury after an infection. Glomerulonephritis may occur with the infection or after a variable latent period. Poststreptococcal glomerulonephritis (PSGN) is the prototype of infection-related glomerulonephritis. The streptococcal antigens, nephritis-associated plasmin-like receptor and streptococcal exotoxin B, have emerged
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HIV and Associated TB: A Lethal Association for Kidney Health? Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-20 Robert Kalyesubula, Nicola Wearne, Mary Kubo, Nadia Hussey, Saraladevi Naicker
Human immunodeficiency virus (HIV) and tuberculosis (TB) are the leading infectious causes of death globally. The combined brunt of these diseases is experienced mainly in low-income and lower-middle-income countries. HIV/TB have devastating effects on the kidneys, leading to accelerated decline of kidney function as well as mortality. Managing the triad of TB/HIV and kidney disease is challenging
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Bleeding Risk in Hemodialysis Patients Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-18 Anita van Eck van der Sluijs, Pearl Pai, Wenjuan Zhu, Gurbey Ocak
Cardiovascular diseases are highly prevalent among patients on dialysis. For these diseases, antiplatelets and antithrombotic therapies including heparin, vitamin K antagonists, and direct oral anticoagulants, are being used. However, the benefit–risk balance of these therapies could differ for dialysis patients compared with the general population. This review article focuses on the bleeding risk
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Patient Perspectives on Clotting in the Extracorporeal Circuit and Decision-Making Regarding Anticoagulation Therapy Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-17 Chandana Guha, Daniel Gallego, Amanda Grandinetti, Madeleine Warren, Allison Jaure
Clotting of the extracorporeal circuit is a complication in the process of hemodialysis that can result in missed or shortened dialysis sessions, higher nursing workload, and elevated cost of treatment. Repercussions of inadequate dialysis may include patient blood loss, fluid overload, build-up of minerals, higher hospitalization rates, and poor quality of life, contributing to increased patient distress
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Clotting of the Extracorporeal Circuit in Hemodialysis: Beyond Contact-Activated Coagulation Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-16 Matthias M. Engelen, Peter Verhamme, Thomas Vanassche
Thrombotic complications in patients with end-stage kidney disease are frequent. While being a lifesaving treatment for these patients, hemodialysis introduces a thromboinflammatory environment. Additionally, the extracorporeal hemodialysis circuit itself is prone to clotting because of an interaction between different activation mechanisms of the coagulation system, platelets, and the immune system
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Avoiding Systemic Heparinization During Hemodialysis: How the Dialysis Setup Might Help Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-13 Florine V. Janssens, Björn Meijers, Karlien François
Heparin is the most widely used anticoagulant for maintaining patency of the extracorporeal blood circuit during intermittent hemodialysis. Inadvertently, this leads to systemic heparinization of the patient. Repeated intermittent heparinization during hemodialysis has been associated with increased bleeding risks and metabolic and immunologic effects. Alternative strategies for minimizing systemic
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Neglected and Emerging Infections of The Kidney Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-12 Ifeoma I. Ulasi, Emmanuel A. Burdmann, Chinwuba K. Ijoma, Li-Fang Chou, Chih-Wei Yang
Individuals, societies, and the environment are affected by neglected and emerging diseases. These diseases result in a variety of severe outcomes, including permanent disabilities, chronic diseases such as chronic kidney disease, and even mortality. Consequences include high health care expenditures, loss of means of support, social stigma, and social exclusion. The burden of these diseases is exacerbated
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Regional Citrate Anticoagulation: A Tale of More Than Two Stories Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-11 Thomas Demuynck, Muriel Grooteman, Piet Ter Wee, Mario Cozzolino, Björn Meijers
Calcium is a key clotting factor, and several inorganic molecules that bind to calcium have been found to reduce the clotting propensity of blood. Citrate, a calcium chelator, is used as inhibitor of the coagulation cascade in blood transfusion. Also, it is used as an anaticoagulant during dialysis to maintain patency of the extracorporeal circuit, known as regional citrate anticoagulation (RCA). The
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Anticoagulation for Hemodialysis: A Hidden Quest to Ensure Safe Dialysis Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-10 Karlien François, Björn Meijers
Abstract not available
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Immunologic Effects of Heparin Associated With Hemodialysis: Focus on Heparin-Induced Thrombocytopenia Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-08 Theodore E. Warkentin
Intermittent hemodialysis (HD) is almost invariably performed with heparin, and thus HD patients are at risk of developing the immune-mediated adverse effect heparin-induced thrombocytopenia (HIT), caused by anti-platelet factor 4/heparin IgG, which strongly activates platelets. HIT patients develop hypercoagulability with greatly increased risk of thrombosis, both venous and arterial. Certain HIT-associated
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Health Systems Preparedness for Infectious Disease Outbreaks: Relevance for Nephrology Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-10 Priti Meena, Dina Abdellatif, Vaibhav Tiwari, Santanu Chatterjee, Valerie A. Luyckx
The coronavirus disease (COVID-19) crisis glaringly highlighted the critical need to develop resilient health care systems that are better prepared for epidemics. Millions of people died from COVID-19 itself, but almost three times as many died from health system disruptions. People living with kidney disease are highly vulnerable during outbreaks and pandemics and their needs must be included in preparedness
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COVID and the Kidney: An Update Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-09 Samira Bell, Griffith B. Perkins, Urmila Anandh, P. Toby Coates
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global pandemic that continues to be responsible for ongoing health issues for people worldwide. Immunocompromised individuals such as kidney transplant recipients and dialysis patients have been and continue to be among the most affected, with poorer outcomes after infection, impaired response
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Lipid and Bone Effects of Heparin Use During Hemodialysis Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-09 Bernd Stegmayr, Li Zuo, Ward Zadora
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are commonly prescribed anticoagulants for chronic hemodialysis (HD). The dialysis population comprises a unique group that receives heparin three times per week for a long period, with potential long-term cumulative metabolic effects such as osteoporosis and worsening lipid profile. HD patients have approximately half the number
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Strategies to Prevent Infections in Dialysis Patients Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-09 Daniela Ponce, Dorothea Nitsch, Talat Alp Ikizler
Infections are the second leading cause of death among patients with end-stage kidney disease, behind only cardiovascular disease. In addition, patients on chronic dialysis are at a higher risk for acquiring infection caused by multidrug-resistant organisms and for death resulting from infection owing to their likelihood of requiring treatment that involves invasive devices, their frequent exposure
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Introduction: Infections and the Kidney: An Area of Resurgent Concern Semin. Nephrol. (IF 3.3) Pub Date : 2024-01-03 Robert Kalyesubula, Urmila Anandh
Abstract not available
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Infections and Acute Kidney Injury: A Global Perspective Semin. Nephrol. (IF 3.3) Pub Date : 2023-12-28 Anthony Batte, Lubaba Shahrin, Rolando Claure-Del Granado, Valerie A. Luyckx, Andrea L. Conroy
Globally, there are an estimated 13.3 million cases of acute kidney injury (AKI) annually. Although infections are a common cause of AKI globally, most infection-associated AKI occurs in low- and lower-middle-income countries. There are marked differences in the etiology of infection-associated AKI across age groups, populations at risk, and geographic location. This article provides a global overview
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Introduction: ISN Frontiers Meeting on “Infections and the Kidney” Semin. Nephrol. (IF 3.3) Pub Date : 2023-12-18 Saraladevi Naicker, Chih-Wei Yang, Vivekanand Jha
Abstract not available
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Understanding Similarities and Differences in CKD and Dialysis Care in Children and Adults Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-27 Guillaume Mahamat Abderraman, Abdou Niang, Tahagod Mohamed, John D. Mahan, Valerie A. Luyckx
In lower-income settings there is often a dearth of resources and nephrologists, especially pediatric nephrologists, and individual physicians often find themselves caring for patients with chronic kidney diseases and end-stage kidney failure across the age spectrum. The management of such patients in high-income settings is relatively protocolized and permits high-volume services to run efficiently
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Nutrition Management for Chronic Kidney Disease: Differences and Special Needs for Children and Adults Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-18 Robert H. Mak, Arpana Iyengar, Angela Yee-Moon Wang
Common goals of nutritional therapy across the spectrum of pediatric and adult chronic kidney disease (CKD) include maintaining normal body mass and composition and reducing associated morbidity and mortality. Adult nephrologists caring for children and adolescents may be challenged by the existing complexities in identifying and interpreting the nutritional status and growth in children. Pediatric
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Tubular Diseases and Stones Seen From Pediatric and Adult Nephrology Perspectives Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-14 Johannes Münch, Paul R. Goodyer, Carsten A. Wagner
The tubular system of the kidneys is a complex series of morphologic and functional units orchestrating the content of tubular fluid as it flows along the nephron and collecting ducts. Renal tubules maintain body water, regulate electrolytes and acid–base balance, reabsorb precious organic solutes, and eliminate specific metabolites, toxins, and drugs. In addition, decisive mechanisms to adjust blood
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Acute Kidney Injury: Gaps and Opportunities for Knowledge and Growth Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-13 Rolando Claure-Del Granado, Javier A. Neyra, Rajit K. Basu
Acute kidney injury (AKI) occurs frequently in hospitalized patients, regardless of age or prior medical history. Increasing awareness of the epidemiologic problem of AKI has directly led to increased study of global recognition, diagnostic tools, both reactive and proactive management, and analysis of long-term sequelae. Many gaps remain, however, and in this article we highlight opportunities to
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Introduction Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-10 Ajay K. Singh, Rajiv Agarwal
Abstract not available
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HUS and TTP: traversing the disease and the age spectrum Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-10 Roberta Donadelli, Aditi Sinha, Arvind Bagga, Marina Noris, Giuseppe Remuzzi
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is characterized by microvascular thrombosis with consequent thrombocytopenia, microangiopathic hemolytic anemia and/or multiorgan dysfunction. In the past, the distinction between HUS and TTP was predominantly based on clinical
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Approach to Diagnosis and Management of Hypertension: A Comprehensive and Combined Pediatric and Adult Perspective Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-10 Sabine Karam, Debbie L. Cohen, Pauline Abou Jaoude, Janis Dionne, FangChao Linda Ding, Anika Garg, Elliot Koranteng Tannor, Rahul Chanchlani
The global prevalence of primary hypertension has been increasing both in children and in the adolescent and adult populations and can be attributed to changes in lifestyle factors with an obesity epidemic, increased salt consumption, and sedentary lifestyles. Childhood blood pressure is the strongest predictor of adult hypertension. Although hypertension in adults is associated strongly with an increased
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Children Are Not Small Adults: Similarities and Differences in Renal Transplantation Between Adults and Pediatrics Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-10 Dechu Puliyanda, Zibya Barday, Zunaid Barday, Andrew Freedman, Tsuyoshi Todo, Allen Kuang Chung Chen, Bianca Davidson
Kidney transplantation is the treatment of choice for all patients with end-stage kidney disease, including pediatric patients. Graft survival in pediatrics was lagging behind adults, but now is comparable with the adult cohort. Although many of the protocols have been adopted from adults, there are issues unique to pediatrics that one should be aware of to take care of this population. These issues
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Glomerular Diseases Across Lifespan: Key Differences in Diagnostic and Therapeutic Approaches Semin. Nephrol. (IF 3.3) Pub Date : 2023-11-08 Martin Windpessl, Balazs Odler, Ingeborg M. Bajema, Duvuru Geetha, Marcus Säemann, Jiwon M. Lee, Augusto Vaglio, Andreas Kronbichler
Glomerular diseases are common causes of chronic kidney disease in childhood, adolescence, and adulthood. The epidemiology of glomerular diseases differs between different age groups, with minimal change disease being the leading cause of nephrotic syndrome in childhood, while membranous nephropathy and focal segmental glomerulosclerosis are more common in adulthood. IgA vasculitis is also more common
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Introduction: Learning From Each Other: Pediatric and Adult Perspectives to Optimize Kidney Care Across the Life Span Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-31 Arpana Iyengar, Valerie A. Luyckx
Abstract not available
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Role of Cell-Based Therapies in T2D Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-31 Sudipta Ashe, Matthias Hebrok
Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination of impaired insulin secretion from β cells residing within the islets of the pancreas and peripheral insulin resistance. In this article, we discuss the current state and risk factors for T2D, conventional
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Role of Inflammation in Progression of Chronic Kidney Disease in Type 2 Diabetes Mellitus: Clinical Implications Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-30 Yasuhiro Oda, Hiroshi Nishi, Masaomi Nangaku
Progression of chronic kidney disease in type 2 diabetes has been understood conventionally as a consequence of intraglomerular hemodynamic changes and aberrant metabolic pathways. However, an increasing body of experimental evidence has highlighted the role of inflammatory response in the progression of diabetic kidney disease. Macrophage polarization in response to specific microenvironmental stimuli
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Congenital Anomalies of the Kidney and Urinary Tract: A Continuum of Care Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-28 Bärbel Lange-Sperandio, Hans-Joachim Anders, Maximilian Stehr, Robert L. Chevalier, Richard Klaus
Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and adolescents. CAKUT describes a wide spectrum of structural disorders with a prenatal origin. The etiology of CAKUT is multifactorial, including environmental, nongenetic, and genetic causes that impact kidney development as well as upper and lower urinary tract development. Adult nephrologists
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Management of Heart Failure With Reduced Ejection Fraction in Patients With Diabetes Mellitus and Chronic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-21 Muhammad Shahzeb Khan, Ahmed Mustafa Rashid, Tariq Shafi, Joao Pedro Ferreira, Javed Butler
Heart failure (HF), diabetes, and chronic kidney disease (CKD) frequently coexist, with one comorbidity worsening the prognosis of another. β-blockers, angiotensin-receptor–neprilysin inhibitors, renin-angiotensin-aldosterone system inhibitors, mineralocorticoid-receptor antagonists, and sodium-glucose cotransporter-2 inhibitors all have been shown to reduce mortality in patients with HF with reduced
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Flattening the Playing Field for Treatment of Diabetic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-21 Keith C. Norris, Sandra F. Williams, Robert Nee
Diabetic kidney disease (DKD) remains a major health care issue and is beset with significant racial and ethnic disparities in regard to its incidence, progression, and complication rate. An individual's health is influenced strongly by an array of societal-level factors commonly called the social determinants of health. Among these, DKD is influenced highly by structured resources and opportunities
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Incorporating Evidence and Guidelines for Personalized Care of Diabetes and Chronic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-17 Joshua J. Neumiller, Radica Z. Alicic, Katherine R. Tuttle
Chronic kidney disease (CKD) represents a particularly challenging diabetes complication. Diabetes now is responsible for half of all cases of CKD, thus making diabetes the most common cause of kidney failure worldwide. In patients with diabetes, CKD frequently coexists with heart failure and atherosclerotic cardiovascular disease, which together are associated with marked increases in the risk of
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Sixty Years of Confronting Diabetes and Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-18 Friedrich C. Luft
The good old days were not good, at least in terms of treating patients with type 2 diabetes. In the 1960s, the development of a radioimmunoassay for insulin permitted determination of the distinguishing features of type 1 and type 2 diabetes. The latter was treated with sulfonylureas and then phenformin, although the mechanisms of action at the time were unknown. The University Group Diabetes Program
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Precision Medicine and/or Biomarker Based Therapy in T2DM: Ready for Prime Time? Semin. Nephrol. (IF 3.3) Pub Date : 2023-10-18 Peter Rossing, Marie Frimodt-Møller, Frederik Persson
Approximately 30–40% of people with type 2 diabetes mellitus develop chronic kidney disease. This is characterised by elevated blood pressure, declining kidney function and enhanced cardiovascular morbidity and mortality. Increased albuminuria and decreasing estimated glomerular function has to be evaluated regularly to diagsnose kidney disease. New biomarkers may facilitate early diagnosis and provide
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Sodium Management in Kidney Disease: Old Stories, New Tricks Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-26 Rengin Elsurer Afsar, Baris Afsar, Talat Alp Ikizler
Excessive dietary sodium intake is associated with an increased risk of hypertension, especially in the setting of chronic kidney disease (CKD). Although implementation of a low-sodium diet in patients with CKD generally is recommended, data supporting the efficacy of this practice is mostly opinion-based. Few controlled studies have investigated the specific association of dietary sodium intake and
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Gut Microbiota-Targeted Interventions in the Management of Chronic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-22 Keiichi Sumida, Joseph F. Pierre, Melana Yuzefpolskaya, Paolo C. Colombo, Ryan T. Demmer, Csaba P. Kovesdy
Summary: Recent advances in microbiome research have informed the potential role of the gut microbiota in the regulation of metabolic, cardiovascular, and renal systems, and, when altered, in the pathogenesis of various cardiometabolic disorders, including chronic kidney disease (CKD). The improved understanding of gut dysbiosis in cardiometabolic pathologies in turn has led to a vigorous quest for
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Organ Crosstalk Contributes to Muscle Wasting in Chronic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-22 Xiaonan H. Wang, S. Russ Price
Muscle wasting (ie, atrophy) is a serious consequence of chronic kidney disease (CKD) that reduces muscle strength and function. It reduces the quality of life for CKD patients and increases the risks of comorbidities and mortality. Current treatment strategies to prevent or reverse skeletal muscle loss are limited owing to the broad and systemic nature of the initiating signals and the multifaceted
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Nutrition Education Models for Patients With Chronic Kidney Disease Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-18 Ban-Hock Khor, Keiichi Sumida, Nicole Scholes-Robertson, Maria Chan, Kelly Lambert, Holly Kramer, Siu-Fai Lui, Angela Yee-Moon Wang
Nutrition is an integral component in the management of chronic kidney disease (CKD), and kidney health professionals play a crucial role in educating patients on dietary interventions for CKD. Several dietary modifications are indicated for CKD that require frequent adaptations with CKD progression and with underlying metabolic disturbances. However, poor adherence to dietary interventions is not
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The Role of Dietary Potassium in the Cardiovascular Protective Effects of Plant-Based Diets Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-04 Olgert Bardhi, Deborah J. Clegg, Biff F. Palmer
Summary: Dietary intervention is an essential factor in managing a multitude of chronic health conditions such as cardiovascular and chronic kidney disease. In recent decades, there has been a host of research suggesting the potential benefit of plant-based diets in mitigating the health outcomes of these conditions. Plant-based diets are rich in vegetables and fruits, while limiting processed food
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Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-04 Kelly Lambert, Robert Gardos, Helen Coolican, Lauren Pickel, Hoon-Ki Sung, Angela Yee-Moon Wang, Albert CM Ong
Polycystic kidney disease (PKD) is a chronic, progressive hereditary condition characterized by abnormal development and growth of cysts in the kidneys and other organs. There is increasing interest in exploring whether dietary modifications may prevent or slow the disease course in people with PKD. Although vasopressin-receptor agonists have emerged as a novel drug treatment in advancing care for
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Is There a Need to “Modernize” and “Simplify” the Diagnostic Criteria of Protein-Energy Wasting? Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-02 Laetitia Koppe, Robert H. Mak
Protein energy wasting(PEW) is a term that most nephrologists used to define nutritional disorders in patients with acute kidney injury and chronic kidney disease. Although this nomenclature is well implemented in the field of nephrology, the use of other terms such as cachexia or malnutritionin the majority of chronic diseases can induce confusion regarding the definition and interpretation of these
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Personalized Low-Protein Diet Prescription in CKD Population: Merging Evidence From Randomized Trials With Observational Data Semin. Nephrol. (IF 3.3) Pub Date : 2023-08-01 Massimo Torreggiani, Angela Yee-Moon Wang, Antioco Fois, Giorgina Barbara Piccoli
Nutritional therapy is a cornerstone of the clinical management of chronic kidney disease (CKD). Nevertheless, randomized controlled trials often have failed to show a relevant benefit of low-protein diets in nonselected CKD populations in terms of slowing the progression of kidney disease and need for dialysis. The more the target population is selected, the less the results can be generalizable to
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Hospice Care in Conservative Kidney Management Semin. Nephrol. (IF 3.3) Pub Date : 2023-07-29 Alexandra E. Bursic, Jane O. Schell
Hospice care offers multidisciplinary expertise to optimize symptom management and quality of life for patients with limited life expectancy and help ensure that patients receive care that reflects their personal goals and values. Many patients receiving conservative kidney management (CKM) and their loved ones can benefit from the additional support that hospice provides, particularly as symptom burdens