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Anticoagulation in Patients with Chronic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-30 Elias John Elenjickal,Christoforos K Travlos,Pedro Marques,Thomas A Mavrakanas
BACKGROUND Both atrial fibrillation and venous thromboembolic disease (VTE) are highly prevalent among patients with chronic kidney disease (CKD). Until recently, warfarin was the most commonly prescribed oral anticoagulant. Direct oral anticoagulants (DOACs) have important advantages and have been shown to be non-inferior to warfarin with respect to stroke prevention or recurrent VTE in the general
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Outcomes of ABO-incompatible living donor kidney transplantation compared to waiting or deceased donor kidney transplantation. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-30 Tai Yeon Koo,Juhan Lee,Yonggu Lee,Hyung Woo Kim,Beom Seok Kim,Kyu Ha Huh,Jaeseok Yang
INTRODUCTION ABO-incompatible (ABOi) living donor kidney transplantation (LDKT) is considered only for patients who do not have an ABO-compatible (ABOc) LD. Therefore, a clinically practical question is whether to proceed with ABOi LDKT or remain on dialysis while waiting for ABOc deceased donor kidney transplantation (DDKT). However, this issue has not been addressed in Asian countries, where ABOi
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Efficacy of Rituximab for Minimal Change Disease and Focal Segmental Glomerulosclerosis with Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome in Adults: A Chinese Multicenter Retrospective Study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-14 Lan Lan,Yuxin Lin,Binfeng Yu,Yin Wang,Hong Pan,Huijing Wang,Xiaowei Lou,Xiabing Lang,Qiankun Zhang,Lie Jin,Yi Yang,Liang Xiao,Jianghua Chen,Fei Han
Introduction Rituximab has been proven effective and safe in pediatric patients with frequently relapsing or steroid-dependent nephrotic syndrome (FR/SDNS). We aimed to analyze the efficacy and safety of rituximab in adult FR/SDNS patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Methods A retrospective cohort study at three nephrology centers in China included
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Virtual Pharmacy: An Integrated Collaborative Redesign Targeting Medication-related Problems in Patients with Chronic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-08 Stephanie W Ong,Abhijat Kitchlu,David Z I Cherney,Karen Leung,Christopher T M Chan
BACKGROUND Collaborative management of kidney disease relies on coordinated and effective partnerships between multiple providers. Siloed traditional health systems often result in delays, barriers to treatment access, and inefficient monitoring. METHODS We conducted a 1-year observational mixed methods study. We included all consecutive referrals except for patients without telephone access. We assessed
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Proton pump inhibitors and hyporesponsiveness to erythropoiesis stimulating agents in hemodialysis patients: results from the Japan Dialysis Outcomes and Practice Patterns Study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-07 Akio Nakashima,Yoshia Miyawaki,Hirotaka Komaba,Noriaki Kurita,Yoshihiro Onishi,Takashi Yokoo,Masafumi Fukagawa
INTRODUCTION Hyporesponsiveness to erythropoiesis stimulating agents (ESAs) is important problem in dialysis patients. While proton pump inhibitors (PPIs) may inhibit iron absorption, few studies have examined associations between PPIs and ESA-resistant anemia in hemodialysis patients. This study examined the associations between PPIs and ESA-resistant anemia in hemodialysis patients. METHODS The present
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Urinary Post-Translationally Modified Fetuin-A Protein is Associated with Increased Risk of Graft Failure in Kidney Transplant Recipients. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-11-06 Firas F Alkaff,Daan Kremer,Charlotte A Te Velde-Keyzer,Jacob van den Born,Stefan P Berger,Gozewijn D Laverman,Lee-Ming Chuang,Tzu-Ling Tseng,Stephan J L Bakker
INTRODUCTION Urinary fetuin-A has been identified as a biomarker for acute kidney injury and is proposed as a biomarker for early detection of kidney function decline. We investigated whether fetuin-A could serve as a marker of graft failure in kidney transplant recipients (KTR). METHODS Data of KTR with a functioning graft ≥ 1 year that were enrolled in the TransplantLines Food and Nutrition Biobank
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Machine Learning Predicts Acute Kidney Injury in Hospitalized Patients with Sickle Cell Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-31 Rima S Zahr,Akram Mohammed,Surabhi Naik,Daniel Faradji,Kenneth I Ataga,Jeffrey Lebensburger,Robert L Davis
INTRODUCTION Acute Kidney Injury (AKI) is common among hospitalized patients with sickle cell disease (SCD) and contributes to increased morbidity and mortality. Early identification and management of AKI is essential to preventing poor outcomes. We aimed to predict AKI earlier in patients with SCD using a machine learning model that utilized continuous minute-by-minute physiological data. METHODS
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Study Design and Baseline Characteristics for Aldosterone Synthase Inhibition in CKD. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-30 Katherine R Tuttle,Peter Rossing,Sibylle J Hauske,Lisa Cronin,Joanna Hussain,Dick de Zeeuw,Hiddo J L Heerspink
INTRODUCTION Aldosterone synthase (AS) inhibition may overcome increased aldosterone production in response to renin-angiotensin system inhibition. BI 690517 is an AS inhibitor under investigation for chronic kidney disease (CKD). METHODS This multinational, Phase II, double-blind study (NCT05182840) investigated the efficacy and safety of daily oral BI 690517, with or without empagliflozin 10 mg,
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Sickle Cell Disease and CKD: An Update. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-27 Rima S Zahr,Santosh Saraf
BACKGROUND Sickle cell disease is an inherited red blood cell disorder that affects approximately 100,000 people in the U.S. and 25 million people worldwide. Vaso-occlusion and chronic hemolysis lead to dysfunction to vital organ systems, with the kidneys being among the most commonly affected organs. SUMMARY Early renal manifestations include medullary ischemia with loss of urine concentrating ability
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Biomarker Enrichment in Sepsis Associated Acute Kidney Injury: Finding High-Risk Patients in the ICU. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-16 Louis Baeseman,Samantha Gunning,Jay L Koyner
Abstract: Background: Sepsis associated Acute kidney injury (AKI) is a leading comorbidity in admissions to the intensive care unit. While a gold standard definition exists, it remains imperfect and does not allow for the timely identification of patients in the setting of critical illness. This review will discuss the use of biochemical and electronic biomarkers to allow for prognostic and predictive
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Urinary Fetuin-A Fragments Predict Progressive eGFR Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-09 Gwo-Tsann Chuang,Daan Kremer,Chi-Hsuan Huang,Firas F Alkaff,Chih-Hung Lin,Tzu-Ling Tseng,Gozewijn D Laverman,Stephan J L Bakker,Lee-Ming Chuang
Introduction There is a great clinical need for novel markers to predict kidney function decline in patients with type 2 diabetes. We explored the potential of post-translationally modified fetuin-A fragments in urine (uPTM-FetA) as such a marker. Methods We included patients with type 2 diabetes from two independent, non-overlapping prospective cohort studies. A cut-off for uPTM-FetA, measured via
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Efficacy and safety of ferric citrate on hyperphosphatemia among Chinese patients with chronic kidney disease undergoing hemodialysis: a phase III multicenter randomized open-label active-drug controlled study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-09 Yong Wang,Xiangmei Chen,Hanyu Zhu,Zhiyong Guo,Yibin Yang,Ping Luo,Yani He,Yan Xu,Daxi Ji,Xinlu Gao,Xiuli Sun,Changying Xing,Yu Wang,Xiaohui Wang,Shuping Zhao,Yan Guan,Hongli Lin,Aimin Zhong,Hua Shui,Fengmin Shao,Lu Lv,Yuehong Yan,Xiaokun Sun,Lei Zhang
BACKGROUND Hyperphosphatemia in CKD patients is positively associated with mortality. Ferric citrate is a potent phosphorus binder that lowers serum phosphorus level and improves iron metabolism. We compared its efficacy and safety with active drugs in Chinese CKD patients with hemodialysis. TRIAL DESIGN This is an open-label active-drug-controlled multicenter randomized study. METHODS Chinese patients
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Predictors of hyporesponsiveness to erythropoiesis-stimulating agents in patients with non-dialysis-dependent chronic kidney disease (RADIANCE-CKD Study). Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-04 Kaori Mase,Kunihiro Yamagata,Hiroyasu Yamamoto,Kazuhiko Tsuruya,Hiroki Hase,Shinichi Nishi,Masaomi Nangaku,Takashi Wada,Terumasa Hayashi,Yukari Uemura,Hideki Hirakata
INTRODUCTION Hyporesponsiveness to erythropoiesis-stimulating agents (ESA) has been associated with increased mortality and cardiovascular events in patients with chronic kidney disease. We hypothesized that the prediction of ESA resistance when ESA administration would be very useful in deciding on a treatment plan. METHODS Patients enrolled in a randomized controlled trial to evaluate renal prognosis
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Altered intestinal microbial flora and metabolism in patients with idiopathic membranous nephropathy. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-04 Xiaohu Shi,Zhaojun Li,Weifeng Lin,Wenying Shi,Rongrong Hu,Gang Chen,Xuemei Li,Xuewang Li,Sen Zhang
INTRODUCTION Dysbiosis of the intestinal microbiome and related metabolites have been observed in chronic kidney disease (CKD), yet their roles in idiopathic membranous nephropathy (IMN) is poorly understood. METHODS In this study, we describe the variation of intestinal bacteria and fecal metabolites in patients with IMN in Chinese population. Stool samples are collected from 41 IMN patients at the
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Effects of Mineralocorticoid Receptor Antagonists for Chronic Kidney Disease: A Systemic Review and Meta-Analysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-04 Chen-Yi Yuan,Yuan-Cheng Gao,Yi Lin,Lin Liu,Xiao-Gang Shen,Wen-Li Zou,Min-Min Wang,Quan-Quan Shen,Li-Na Shao,Yue-Ming Liu,Jia-Wei Zhang,Zhi-Hui Pan,Yan Zhu,Jing-Ting Yu,Xu-Guang Yu,Bin Zhu
INTRODUCTION The benefits and harms of different mineralocorticoid receptor antagonists (MRAs) in chronic kidney disease (CKD) are inconsistent. We aimed to summarize the significance of MRAs in treating CKD. METHODS We searched MEDLINE, EMBASE, and the Cochrane databases for trials assessing the effects of MRAs on non-dialysis-dependent CKD populations. Treatment and adverse effects were summarized
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Autonomic nervous system dysfunction in peritoneal dialysis patients: an underrecognized cardiovascular risk factor? Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-03 Danai Faitatzidou,Artemios G Karagiannidis,Marieta P Theodorakopoulou,Andrew Xanthopoulos,Filippos Triposkiadis,Pantelis A Sarafidis
BACKGROUND In patients with end-stage kidney disease (ESKD) receiving peritoneal dialysis (PD) cardiovascular events represent the predominant cause of morbidity and mortality, with cardiac arrhythmias and sudden death being the leading causes of death in this population. Autonomic nervous system (ANS) dysfunction is listed among the non-traditional risk factors accounting for the observed high cardiovascular
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Risk factors for fractures in renal transplantation: a population-based cohort study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-10-02 Hsin-Lin Tsai,Tzu-Ching Lin,Niang-Cheng Lin,Hui-Hsin Yang,Jei-Wen Chang
INTRODUCTION Kidney transplant recipients are at an increased risk of fractures, and targeted preventive strategies are needed. Therefore, in this retrospective cohort study, we investigated a large population-based cohort to identify the transplant recipient-specific risk factors for fractures in Taiwanese kidney transplant recipients. METHODS We conducted a retrospective cohort study using the National
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Targeting monocyte derived CCL17 attenuates murine crescentic glomerulonephritis by affecting renal CCR4+ regulatory T cell recruitment. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-23 Ning Song,Hans-Joachim Paust,Nariaki Asada,Anett Peters,Anna Kaffke,Christian F Krebs,Ulf Panzer,Jan-Hendrik Riedel
INTRODUCTION The chemokine receptor CCR4 is expressed by divers CD4+ T cell subsets including regulatory T cells (Tregs) but its functional importance for leukocyte recruitment and the relevance of its two corresponding chemokines CCL17 and CCL22 have not been studied in immune mediated crescentic glomerulonephritis (cGN). METHODS Utilizing the single cell RNA sequencing (scRNAseq) data in analyzing
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Future Directions in Optimizing Anesthesia to Reduce Perioperative Acute Kidney Injury. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-22 Bin Zeng,Yinuo Liu,Jiawei Xu,Liyan Niu,Yuting Wu,Deju Zhang,Xiaoyi Tang,Zicheng Zhu,Yixuan Chen,Leilei Hu,Shuchun Yu,Peng Yu,Jing Zhang,Wenting Wang
BACKGROUND Perioperative acute kidney injury (AKI) is common in surgical patients and is associated with high morbidity and mortality. There are currently few options for AKI prevention and treatment. Due to its complex pathophysiology, there is no efficient medication therapy to stop the onset of the injury or repair the damage already done. Certain anesthetics, however, have been demonstrated to
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Green tea polyphenols alleviate kidney injury induced by di(2-ethylhexyl) phthalate in mice. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-21 Heng Shi,Xinhai Zhao,Peng Qin,Xianling Zhou,Sisi Liu,Chuanchuan Sun,Qiuyu Cao,Shiping Zhu,Shengyun Sun
BACKGROUND Di(2-ethylhexyl) phthalate (DEHP) is a common plasticizer. Studies have revealed that DEHP exposure can cause kidney damage. Green tea is among the most popular beverages in China. Green tea polyphenols (GTPs) have been proven to have therapeutic effects on organ damage induced by heavy metal exposure. However, few studies have reported on GTP relieving DEHP-induced kidney damage. METHODS
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Clinicopathological Features and Outcomes of IgA Nephropathy with Serum Antineutrophil Cytoplasmic Autoantibody Positivity. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-19 Wenchao Li,Ruifan Chen,Wei Chen,Fengxian Huang,Xi Xia
INTRODUCTION IgA nephropathy (IgAN) with serum antineutrophil cytoplasmic autoantibody (ANCA) positivity is uncommon. This study analyzed the clinicopathologic features and prognosis of IgAN patients with serum ANCA positivity. METHODS 2,864 IgAN patients were tested for ANCA by the indirect immunofluorescence assay and chemiluminescence immunoassay. Patients with serum ANCA positivity (n = 85) were
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Racial Disparities in End-Stage Kidney Disease Outcomes Among Asians and Native Hawaiians and Other Pacific Islanders Across Geographic Residence. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-19 Amy S You,Keith C Norris,Merle Kataoka-Yahiro,James Davis,Victoria Page,Glen Hayashida,Yoko Narasaki,Shiuh Feng Cheng,Roland Ng,Linda L Wong,Felix Lee,Kamyar Kalantar-Zadeh,Connie M Rhee
INTRODUCTION While Asians and Native Hawaiian and other Pacific Islanders (NHOPIs) have a high prevalence of kidney disease risk factors, there are sparse data examining their end-stage kidney disease (ESKD) outcomes. As Hawaii has high representation of Asians and NHOPIs, we compared their ESKD outcomes based on residence in the Mainland US vs. Hawaii/Pacific Islands (PIs). MATERIALS AND METHODS Using
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Maintaining Renin-Angiotensin-Aldosterone System Inhibitor Treatment with Patiromer in Hyperkalaemic Chronic Kidney Disease Patients: Comparison of a Propensity-Matched Real-World Population with AMETHYST-DN. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-19 Rajkumar Chinnadurai,Sharmilee Rengarajan,Jeffrey J Budden,Carol Moreno Quinn,Philip A Kalra
INTRODUCTION Guideline-directed renin-angiotensin-aldosterone system inhibitor (RAASi) therapy is rarely achieved in clinical settings, often due to hyperkalaemia. We assessed the potassium binder, patiromer, on continuation of RAASi therapy in hyperkalaemic patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) in the AMETHYST-DN trial, propensity score-matched to a real-world
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Cardiorenal Outcomes with Finerenone in Asian Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELIO-DKD post hoc Analysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-14 Daisuke Koya,Stefan D Anker,Luis M Ruilope,Peter Rossing,ZhiHong Liu,Byung Wan Lee,Chien-Te Lee,Charlie Scott,Peter Kolkhof,Robert Lawatscheck,Lili Wang,Amer Joseph,Bertram Pitt,
INTRODUCTION In FIDELIO-DKD, finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease and type 2 diabetes (T2D). This post hoc analysis explores finerenone in patients from the Asian region. METHODS In FIDELIO-DKD, 5,674 patients with T2D and urine albumin-to-creatinine ratio (UACR) ≥30-<300 mg/g and estimated glomerular filtration rate (eGFR) ≥25-<60 mL/min/1
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Clinicopathological characteristics and prognosis of lupus nephritis patients with acute kidney injury. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-14 Suchun Li,Qimei Luo,Yuting Fan,Chen Zhao,Fengxian Huang,Xi Xia,Wei Chen
BACKGROUND Acute kidney injury (AKI) is common in lupus nephritis (LN) and a risk factor for chronic kidney failure. Here we aimed to assess the characteristics and prognosis of LN patients with AKI. METHODS AKI and AKI severity stages in LN patients were defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification. Long-term renal outcomes and patient mortality between different
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Coexistence of low muscle mass and osteoporosis as a predictor of fragility fractures in long-term kidney transplant recipients. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-12 Mayuko Hori,Hiroshi Takahashi,Chika Kondo,Yutaka Matsuoka,Makoto Tsujita,Morikuni Nishihira,Kazuharu Uchida,Asami Takeda,Kunio Morozumi,Shoichi Maruyama
INTRODUCTION Sarcopenia and osteoporosis are highly prevalent among kidney transplant recipients (KTRs). Although osteoporosis is known to increase fracture risk in KTRs, it is unclear whether sarcopenia or osteosarcopenia is associated with this increased risk. Thus, we aimed to investigate the association of the coexistence of low muscle mass (LMM) and osteoporosis with the risk of fracture in long-term
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A 4-Variable Model to Predict Cardio-Kidney Events and Mortality in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-09-06 Luís Mendonça,Miguel Bigotte Vieira,João Sérgio Neves,Paulo Castro Chaves,Joao Pedro Ferreira
INTRODUCTION Current prognostic models for chronic kidney disease (CKD) are complex and were designed to predict a single outcome. We aimed to develop and validate a simple and parsimonious prognostic model to predict cardio-kidney events and mortality. METHODS Patients from the CRIC Study (n = 3,718) were randomly divided into derivation (n = 2,478) and validation (n = 1,240) cohorts. Twenty-nine
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Durability of the Blood Pressure Effects of Renal Pelvis Denervation in Patients with Hypertension During a 12-Month Observation. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-31 Michael A Weber,Dagmara Hering,David Nikoleishvili,Avtandil Imedadze,Gvantsa Dughashvili,Zurab Klimiashvili,Eter Bekaia,Tamar Shengelia,Mamuka Kabalava,Otar Goguadze,Tamar Emukhvari,Vitaly Druker,Terry Buelna,Richard Heuser,Shima Hashemian,Robert Provanzano
INTRODUCTION We previously completed a trial of renal pelvic denervation for treating hypertension that reduced blood pressure by the 2-month primary endpoint. However, information on the durability of effectiveness is a critical requirement for device therapy and we now report data up to 12 months. METHODS This was an open label single-arm feasibility study in patients with increased blood pressure
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One more step in the renal denervation trek. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-31 Raymond R Townsend
Is This REALLY Required?
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Comment on Kang et al.'s "Comparison between the Effects of Allopurinol and Febuxostat on the Survival of Patients on Maintenance Hemodialysis". Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-17 Shih-Wei Lai
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Life's Essential 8 and Mortality in US Adults with Chronic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-17 Hongyu Chen,Haoxian Tang,Jingtao Huang,Nan Luo,Xuan Zhang,Xin Wang
INTRODUCTION The current prevalence of chronic kidney disease (CKD) is substantial, and CKD individuals face a heightened risk of mortality, encompassing both all-cause and cause-specific outcomes. The current study aims to investigate the potential impact of adhering to Life Essential 8 (LE8) on reducing mortality among CKD individuals. METHODS Using the National Health and Nutrition Survey (NHANES)
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High osmol gap hyponatremia caused by icodextrin: A case series report. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-14 Caroline W H de Fijter,Joanna Stachowska-Pietka,Jacek Waniewski,Bengt Lindholm
Recently hyperosmolar hyponatremia following excessive off-label use of two exchanges of 2L icodextrin daily during peritoneal dialysis (PD) was reported. We encountered a cluster of three cases of PD patients who developed hyperosmolar hyponatremia during on-label use of icodextrin. This appeared to be due to absorption of icodextrin, since, after stopping icodextrin, the serum sodium level and osmol
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Glomeruli count and arterial injury in real-time ultrasound-guided needle kidney biopsy specimens: Adequacy of three approaches for pig kidneys. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-14 Tomohiko Nishino,Sakurako Hirano,Shin Takemura,Shinya Tomori,Sayaka Ono,Kazuhiro Takahashi,Masakazu Mimaki
INTRODUCTION Real-time ultrasound-guided percutaneous kidney biopsy is essential for diagnosis and treatment planning; nonetheless, the optimal puncture approach has yet to be established. In vivo, performing different approaches on the same patient at once is not possible. This study aimed to determine the impact of different approaches on the number of obtained glomeruli and their potential to cause
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Effects of Different Exercises on Physical Function, Dialysis Adequacy, and Health-Related Quality of Life in Maintenance Hemodialysis Patients: A Systematic Review and Network Meta-Analysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-08-03 Huagang Hu,Chanchan Wu,Jojo Yan Yan Kwok,Mu-Hsing Ho,Pui Hing Chau,Kris Yuet Wan Lok,Edmond Pui Hang Choi
BACKGROUND Clinical guidelines recommend exercise training for patients undergoing maintenance hemodialysis (MHD). However, the effectiveness of different types of exercise remains uncertain. OBJECTIVES The aims of the study were to compare and rank the effect of different types of exercise on walking capacity, cardiorespiratory fitness, dialysis adequacy, and health-related quality of life (HRQOL)
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Impact of the COVID-19 pandemic on the provision of dialysis service and mortality in Veterans receiving maintenance hemodialysis in the VA: an interrupted time-series analysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-07-31 Samir Patel,Eduardo A Trujillo Rivera,Venkatesh K Raman,Charles Faselis,Virginia Wang,Jeffrey C Fink,Jeffrey M Roseman,Charity J Morgan,Sijian Zhang,Helen M Sheriff,Michael S Heimall,Wen-Chih Wu,Qing Zeng-Treitler,Ali Ahmed
INTRODUCTION According to the United States Renal Data System (USRDS), patients with end-stage kidney disease (ESKD) on maintenance dialysis had higher mortality during early COVID-19 pandemic. Less is known about the effect of the pandemic on the delivery of outpatient maintenance hemodialysis, and its impact on death. We examined the effect of pandemic-related disruption on the delivery of dialysis
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Nephrogenic Calciphylaxis Arising After Bariatric Surgery: A Case Series. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-07-24 Joyce Xia,Alice J Tan,Bianca Biglione,Bethany Cucka,Lauren Ko,Emily Nguyen,Charbel C Khoury,Malcolm Robinson,Sagar U Nigwekar,Daniela Kroshinsky
Nephrogenic calciphylaxis is associated with multiple risk factors including long term dialysis dependence, hyperphosphatemia, hypercalcemia, parathyroid hormone derangements, vitamin K deficiency, obesity, diabetes mellitus, warfarin use, and female sex. Bariatric surgery is known to cause altered absorption, leading to mineral and hormonal abnormalities in addition to nutritional deficiency. Prior
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Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-07-12 Wei-Shun Yang,Gwo-Tsann Chuang,Tony Pan-Hou Che,Li-Yun Chueh,Wen-Yi Li,Chih-Neng Hsu,Chia-Ni Hsiung,Hsiao-Chia Ku,Yi-Ching Lin,Yi-Shun Chen,Siow-Wey Hee,Tien-Jyun Chang,Shiau-Mei Chen,Meng-Lun Hsieh,Hsiao-Lin Lee,Karen Chia-Wen Liao,Chen-Yang Shen,Yi-Cheng Chang
INTRODUCTION Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. METHODS Nondiabetic individuals aged 30-70 years without
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Clinicopathological Characteristics and Impacts on Clinical Outcomes of Thrombotic Microangiopathy Lesions in Patients with Immunoglobulin A Nephropathy in Thailand. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-07-10 Pongpratch Puapatanakul,Athiphat Banjongjit,Talerngsak Kanjanabuch,Jerasit Surintrspanont,Kroonpong Iampenkhae,Kearkiat Praditpornsilpa,Somchai Eiam-Ong,Vijitr Boonpucknavig
INTRODUCTION More reports of thrombotic microangiopathy (TMA) in immunoglobulin A (IgA) nephropathy suggest its association with poor clinical outcomes. However, the prevalence and clinical significance of TMA in IgA nephropathy have not been widely studied in different populations. METHODS Kidney biopsies of all patients with primary IgA nephropathy from 1995 to 2015 at the King Chulalongkorn Memorial
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Tolvaptan's Association with Low Risk of Acute Kidney Injury in Patients with Advanced Chronic Kidney Disease and Acute Decompensated Heart Failure. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-29 Tomoki Tagaya,Hiroki Hayashi,Soshiro Ogata,Kazuo Takahashi,Shigehisa Koide,Daijo Inaguma,Midori Hasegawa,Yukio Yuzawa,Naotake Tsuboi
INTRODUCTION Furosemide, a loop diuretic, is often empirically used to treat acute decompensated heart failure (ADHF) initially. Conversely, decongestion using tolvaptan, an aquaretic, is thought to maintain renal function compared to furosemide. However, it has not been investigated in patients with advanced chronic kidney disease (CKD) at high risk of developing acute kidney injury (AKI). This study
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Thromboelastography and Traditional Coagulation Testing in Non-ICU-Admitted Patients with Acute Kidney Injury: An Observational Cohort Study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-26 Jiajia Liu,Zhongyuan Liu,Tao Zhao,Tao Su,Qizhuang Jin
INTRODUCTION This study aimed to elucidate the coagulation disorders in non-ICU patients with acute kidney injury (AKI) and their contribution to clotting-related outcomes of intermittent kidney replacement therapy (KRT). METHODS We included non-ICU-admitted patients with AKI requiring intermittent KRT, clinically having a risk of bleeding and against systemic anticoagulant use during KRT between April
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Real-World Use of AKI Biomarkers: A Quality Improvement Project Using Urinary Tissue Inhibitor Metalloprotease-2 and Insulin-Like Growth Factor Binding Protein 7 ([TIMP-2]*[IGFBP7]). Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-23 Ashley M La,Samantha Gunning,Sharon A Trevino,Alissa Kunczt,Lui G Forni,Varsha Swamy,Alexander Zarbock,Sarah Groboske,Edward K Y Leung,Kiang-Teck J Yeo,Jay L Koyner
INTRODUCTION Novel urinary biomarkers, including tissue inhibitor metalloprotease-2 and insulin-like growth factor binding protein 7 ([TIMP-2]*[IGFBP7]), have been developed to identify patients at risk for acute kidney injury (AKI). We investigated the "real-world" clinical utility of [TIMP-2]*[IGFBP7] in preventing AKI. METHODS We performed a before and after single-center quality improvement study
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Hitting the Snooze Button on Chronic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-21 Ian M Greenlund,Naima Covassin,Virend K Somers
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Results of Salt Intake Restriction Monitored with the New Sodium Control Biosensor. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-13 Francisco Maduell,Ester Cholbi,Laura Morantes,Víctor Joaquín Escudero-Saiz,Júlia Ollé,Marta Martínez-Chillarón,Lida Maria Rodas,Diana Rodríguez-Espinosa,Marta Arias-Guillen,Manel Vera,Néstor Fontseré,José Jesús Broseta
INTRODUCTION Adherence to a low-sodium (Na) diet is crucial in patients under hemodialysis, as it improves cardiovascular outcomes and reduces thirst and interdialytic weight gain. Recommended salt intake is lower than 5 g/day. The new 6008 CAREsystem monitors incorporate a Na module that offers the advantage of estimating patients' salt intake. The objective of this study was to evaluate the effect
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U-Shaped Relationship between Sleep Duration and CKD in US Adults: Data from National Health and Nutrition Examination Survey (NHANES) 2005-2014. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-12 Luojia Jiang,Haibo Xu
INTRODUCTION Short and long sleep durations have been associated with adverse health outcomes. The objective of this study was to examine the association between self-reported sleep duration and chronic kidney disease (CKD) in the general population on the basis of the National Health and Nutrition Examination Survey (NHANES) database. METHODS A total of 28,239 adults aged ≥18 years who participated
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Association of Intradialytic Hypertension with Future Cardiovascular Events and Mortality in Hemodialysis Patients: Effects of Ambulatory Blood Pressure. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-09 Fotini Iatridi,Marieta P Theodorakopoulou,Antonios Karpetas,Vasiliki Sgouropoulou,Areti Georgiou,Eleni Karkamani,Artemios Karagiannidis,Aikaterini Papagianni,Pantelis Sarafidis
INTRODUCTION Intradialytic hypertension (IDHTN) is associated with increased risk of adverse outcomes. Patients with IDHTN have higher 44-h blood pressure (BP) than patients without this condition. Whether the excess risk in these patients is due to the BP rise during dialysis per se or on elevated 44-h BP or other comorbid conditions is uncertain. This study evaluated the association of IDHTN with
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Risk Factors for Common Kidney Stones Are Correlated with Kidney Function Independent of Stone Composition. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-30 Kathryn E Simmons,Hari R Nair,Manali Phadke,Piruz Motamedinia,Dinesh Singh,Tinika A Montgomery,Neera K Dahl
INTRODUCTION Kidney stone type varies with age, sex, season, and medical conditions. Lower estimate glomerular filtration rate (eGFR) leads to changes in urine chemistry, and risk factors for kidney stones are thought to vary by stone type. We explore the association between eGFR, urine risk factors, and common stone compositions. METHODS This was a retrospective cohort study of 811 kidney stone patients
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Hybrid Method for Peritoneal Dialysis Catheter Insertion: A New Technique for Improved Outcomes and Reduced Costs. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-30 Szu-Yuan Li,Cheng-Yen Chen,Ming-Tsun Tsai,Niang-Cheng Lin,Chin-Su Liu,Chih-Ching Lin
INTRODUCTION Peritoneal dialysis (PD) is a well-established treatment choice for end-stage kidney disease (ESKD). While there are several methods for PD catheter insertion, they each have limitations. In this study, we present a new hybrid method for PD catheter insertion and compare it to the conventional laparoscopic method. METHODS This retrospective study included 171 patients who were undergoing
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Association of Self-Reported Nighttime Sleep Duration with Chronic Kidney Disease: China Health and Retirement Longitudinal Study. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-30 Bingxin Jiang,Dongxu Tang,Neng Dai,Chen Huang,Yahang Liu,Ce Wang,Jiahuan Peng,Guoyou Qin,Yongfu Yu,Jiaohua Chen
INTRODUCTION The cohort study aimed to assess the association of nighttime sleep duration and the change in nighttime sleep duration with chronic kidney disease (CKD) and whether the association between nighttime sleep duration and CKD differed by daytime napping. METHODS This study included 11,677 individuals from the China Health and Retirement Longitudinal Study (CHARLS) and used data from the 2011
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High Renal Mast Cell Density Is Associated with Poor Prognosis in Patients with Immunoglobulin A Nephropathy. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-26 Shujie Wang,Danni Hu,Yue-Qiang Li,Qing Lei,Liu Liu,Xiaofeng He,Min Han,Guangchang Pei,Rui Zeng,Gang Xu
INTRODUCTION This observational cohort study evaluated the prognostic value of mast cells in the pathogenesis and progression of IgA nephropathy. METHODS A total of 76 adult IgAN patients were enrolled into this study from Jan 2007 and June 2010. Immunohistochemistry and immunofluorescence were used to identify tryptase-positive mast cells in renal biopsy samples. Patients were classified into Tryptasehigh
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Interleukin-6-to-Albumin Ratio as a Superior Predictor of Mortality in End-Stage Kidney Disease Patients. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-24 Xiejia Li,Abdul Rashid Qureshi,Mohamed E Suliman,Olof Heimburger,Peter Barany,Peter Stenvinkel,Bengt Lindholm
INTRODUCTION In patients with chronic kidney disease (CKD), high interleukin-6 (IL-6) and low albumin circulating concentrations are associated with worse outcomes. We examined the IL-6-to-albumin ratio (IAR) as a predictor of risk of death in incident dialysis patients. METHODS In 428 incident dialysis patients (median age 56 years, 62% men, 31% diabetes mellitus, 38% cardiovascular disease [CVD])
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Intrarenal Anti-Leptin Treatment Attenuates Ischemia and Reperfusion Injury. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-24 Michael Jonas,Amos J Simon,Boris Gilburd,Jacob Schneiderman
INTRODUCTION Renal ischemia and reperfusion (IR) injury introduces cellular stress and is the main cause of acute kidney damage. Renal cells exposed to noxious stress induce the expression of the pleiotropic hormone leptin. As we have previously revealed a deleterious stress-related role for leptin expression, these results suggested that leptin is also involved in pathological renal remodeling. The
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Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-19 Manuela Yepes-Calderon,Daan Kremer,Adrian Post,Camilo G Sotomayor,Ulrike Seidel,Patricia Huebbe,Tim J Knobbe,Kai Lüersen,Michele F Eisenga,Eva Corpeleijn,Martin H de Borst,Gerjan J Navis,Gerald Rimbach,Stephan J L Bakker
INTRODUCTION In chronic kidney disease, proteinuria increases urinary copper excretion, inducing oxidative tubular damage and worsening kidney function. We investigated whether this phenomenon occurred in kidney transplant recipients (KTRs). In addition, we studied the associations of urinary copper excretion with the biomarker of oxidative tubular damage urinary liver-type fatty-acid binding protein
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High Phosphate-Binding Capacity of Oxylanthanum Carbonate with a Low Medication Volume: Comparison with Commercially Available Phosphate Binders. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-06-27 Stuart M Sprague,Guru Reddy,Douglas Jermasek,Pramod Gupta
BACKGROUND A key focus for chronic kidney disease management is phosphate control, but currently available binders have suboptimal phosphate-binding capacity, and their characteristics result in low adherence and poor phosphate regulation. Oxylanthanum carbonate, a novel compound that uses proprietary nanoparticle technology to deliver lanthanum, has the potential to combine high phosphate-binding
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Discontinuation of Renin-Angiotensin-Aldosterone System Inhibitors Secondary to Hyperkalemia Translates into Higher Cardiorenal Outcomes. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-18 Jaejin An,Hui Zhou,Liang Ni,Teresa N Harrision,Rong Wei,Abiy Agiro,Yasmin Ghanshyam Brahmbhatt,Yemmie Oluwatosin,Craig G Schilling,John J Sim
INTRODUCTION Discontinuation of renin-angiotensin-aldosterone system inhibitor (RAASi) is common after hyperkalemia. We evaluated the risk of kidney and mortality outcomes associated with RAASi discontinuation among patients with chronic kidney disease (CKD) and hyperkalemia. METHODS We identified adult patients with CKD (eGFR <60 mL/min/1.73 m2) who experienced new-onset hyperkalemia (potassium ≥5
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Mortality and Risk Factors in Very Elderly Patients Who Start Hemodialysis: Korean Renal Data System, 2016-2020. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-18 Ji Hyeon Park,Hayne Cho Park,Do Hyoung Kim,Young Ki Lee,AJin Cho
INTRODUCTION The number of elderly patients with end-stage renal disease (ESRD) is increasing worldwide. However, decision-making about elderly patients with ESRD remains complex because of the lack of studies, especially in very elderly patients (≥75 years). We examined the characteristics of very elderly patients starting hemodialysis (HD) and the associated mortality and prognostic factors. METHODS
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Documented Adverse Drug Reactions and Discontinuation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Chronic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-18 L Parker Gregg,Peter A Richardson,Michael A Herrera,Julia M Akeroyd,Shehrezade A Jafry,Glenn T Gobbel,Sheena Wydermyer,Jennifer Arney,Adriana Hung,Michael E Matheny,Salim S Virani,Sankar D Navaneethan
INTRODUCTION Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are frequently discontinued in patients with chronic kidney disease (CKD). Documented adverse drug reactions (ADRs) in medical records may provide insight into the reasons for treatment discontinuation. METHODS In this retrospective cohort of US veterans from 2005 to 2019, we identified individuals
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Discontinuation of Renin-Angiotensin System Inhibitors and Clinical Outcomes in Chronic Kidney Disease: A Systemic Review and Meta-Analysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-18 Chen Tang,Xin-Yan Wen,Ji-Cheng Lv,Su-Fang Shi,Xu-Jie Zhou,Li-Jun Liu,Hong Zhang
BACKGROUND Discontinuation of renin-angiotensin system (RAS) inhibitors is common in patients with chronic kidney disease (CKD), and the potential danger has been reported in several studies. However, a comprehensive analysis has not been conducted. OBJECTIVES This study sought to evaluate the effects of discontinuation of RAS inhibitors in CKD. METHOD Relevant studies up to November 30, 2022, were
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Comparison between the Effects of Allopurinol and Febuxostat on the Survival of Patients on Maintenance Hemodialysis. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-18 Seok Hui Kang,Bo Yeon Kim,Eun Jung Son,Gui Ok Kim,Jun Young Do
INTRODUCTION There were insufficient pieces of evidence regarding the effect of the two drugs (allopurinol and febuxostat) on patient survival in hemodialysis (HD) patients. Herein, we aimed to compare the efficacy of uric acid-lowering drugs (ULDs) or the type of the drug on patient survival using a representative sample of maintenance HD patients in South Korea. METHODS This study used data from
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Mechanistic and Clinical Comparison of the Erythropoietic Effects of SGLT2 Inhibitors and Prolyl Hydroxylase Inhibitors in Patients With Chronic Kidney Disease and Renal Anemia. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-16 Milton Packer
Renal anemia is treated with erythropoiesis-stimulating agents (ESA), even though epoietin alfa and darbepoietin increase the risk of cardiovascular death and thromboembolic events, including stroke. Hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) inhibitors have been developed as an alternative to ESAs, producing comparable increases in hemoglobin. However, in advanced chronic kidney
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Cerebrovascular Pulsatility Index Is Reduced in Autosomal Dominant Polycystic Kidney Disease. Am. J. Nephrol. (IF 4.2) Pub Date : 2023-05-16 Cortney N Steele,Ester S Oh,Wei Wang,Heather Farmer-Bailey,Berenice Y Gitomer,Michel Chonchol,Kristen L Nowak
INTRODUCTION Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion precedes the onset of dementia and is linked to cognitive dysfunction. Autosomal dominant polycystic kidney disease (ADPKD) may increase the risk of dementia, and intracranial aneurysms are more prevalent in ADPKD patients. However, cerebrovascular