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The spectrum of biopsy-proven kidney diseases, causes, and renal outcomes in acute kidney injury patients Nephron (IF 2.5) Pub Date : 2023-04-24 Zulihumaer Abuduwupuer, Qunjuan Lei, Shaoshan Liang, Feng Xu, Dandan Liang, Xue Yang, Xumeng Liu, Caihong Zeng
Abstract Introduction: Acute kidney injury (AKI) is a group of highly heterogeneous, complicated clinical syndromes. Although kidney biopsy plays an irreplaceable role in evaluating complex AKI, a few studies have focused on the clinicopathology of AKI biopsies. This study analyzed the pathological disease spectrum, causes, and renal outcomes of biopsied AKI patients. Methods: We retrospectively included
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Clinicopathological characteristics and outcomes of renal sarcoidosis: A series study of 18 patients from a single center Nephron (IF 2.5) Pub Date : 2023-04-19 Mengyue Zhu, Ling Jiang, Feng Xu, Jing Hu, Shaoshan Liang, Haitao Zhang
Introduction: Sarcoidosis is characterized by non-caseating granulomatous inflammation in multiple organs. Renal involvement is rare, and granulomatous tubulointerstitial nephritis (GIN) is the predominant histologic feature. Renal sarcoidosis (RS) is usually diagnosed by exclusion, combining clinical and histological findings, and often remains misdiagnosed. This retrospective study aimed to describe
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Factors Associated with Mortality and Long-Term Outcomes of Pediatric Acute Kidney Injury in a Resource Limited Setting Nephron (IF 2.5) Pub Date : 2023-04-04 Michael Abel Alao, Olayinka Rasheed Ibrahim, Adebowale Dele Ademola, Adanze Onyenunachi Asinobi
Introduction: Despite being a leading cause of morbidity and mortality globally, acute kidney injury (AKI) is worse in resource-limited areas. This study explores AKI incidence, inhospital mortality, and long-term outcomes in resource-limited settings. Methods: This was a prospective study of children with AKI from 2014 to 2019. KDIGO 2012 defined AKI. We assessed the etiology, inhospital mortality
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Real-World Phosphate Binder Use Among Dialysis-Dependent Patients With CKD Nephron (IF 2.5) Pub Date : 2023-03-30 Todd Berner, Christine Ferro, Gabriela Dieguez, Steve Metz, Jennifer Moore, Erika Szabo, Csaba P. Kovesdy
Introduction: For patients with chronic kidney disease (CKD), the need for phosphate binder (PB) treatment peaks at onset of dialysis. This real-world study assessed rates of PB utilization and switching in patients with dialysis-dependent CKD (DD-CKD). Methods: We identified patients with PB utilization among those with prevalent DD-CKD using 2018-2019 Medicare Parts A/B/D data. Patients were assigned
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A case of kidney transplantation from a deceased donor with acute kidney injury due to rhabdomyolysis Nephron (IF 2.5) Pub Date : 2023-03-24
Acute kidney injury (AKI) due to rhabdomyolysis occurs because of renal ischemia or acute tubular necrosis due to the deposition of myoglobin casts in the renal tubules. Donors with AKI due to rhabdomyolysis are not contraindication for transplantation. However, the dark red kidney raises concerns about renal hypofunction or primary nonfunction after transplantation. We report the case of a 34-year-old
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Current status and perspectives on recurrent IgA nephropathy after kidney transplantation Nephron (IF 2.5) Pub Date : 2023-03-24 Mayuko Kawabe, Izumi Yamamoto
IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. IgAN progresses to end-stage kidney disease in 20-40% of patients within 20 years of diagnosis. Kidney transplantation is the most effective option for patients with end-stage kidney disease caused by IgAN, but recurrence can occur in the transplanted kidney. The IgAN recurrence rate varies from 1% to 10% per year, and
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Significance of multinucleated polyploidization of tubular epithelial cells in kidney allografts Nephron (IF 2.5) Pub Date : 2023-03-24 Noriyuki Kounoue, Hideyo Oguchi, Naobumi Tochigi, Tetuo Mikami, Yutaka Yamaguchi, Kazuho Honda, Takashi Yonekura, Masaki Muramatsu, Yoshihiro Itabashi, Ken Sakai
Introduction: Multinucleated polyploidization (MNP) of tubular epithelial cells is occasionally observed in kidney allografts. The present study aimed to clarify the clinical and pathological significance of MNP of tubular epithelial cells in kidney allografts. Methods: Fifty-eight 1-year biopsies from 58 patients who underwent kidney transplantation at our hospital from January 2016 to December 2017
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A case of hypokalemia caused by left native renal artery stenosis in a kidney transplant recipient Nephron (IF 2.5) Pub Date : 2023-03-20 Yuki Shiina, Akimitsu Kobayashi, Izumi Yamamoto, Nagisa Koda, Kotaro Miyazawa, Mayuko Kawabe, Naoki Sugano, Fumihiko Urabe, Jun Miki, Hiroki Yamada, Takahiro Kimura, Yukio Maruyama, Yudo Tanno, Ichiro Ohkido, Hiroyasu Yamamoto, Takashi Yokoo
A 39-year-old woman with end-stage renal failure of unknown origin was on peritoneal dialysis for 10 years. One year ago, she underwent ABO-incompatible living-donor kidney transplantation from her husband. After the kidney transplantation, her serum creatinine level remained around 0.7 mg/dL, but her serum potassium level remained low at around 3.5 mEq/L despite potassium supplementation and spironolactone
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Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic active T-cell mediated Rejection Nephron (IF 2.5) Pub Date : 2023-03-16 Izumi Yamamoto, Mayuko Kawabe, Ayaka Hayashi, Akimitsu Kobayashi, Hiroyasu Yamamoto, Takashi Yokoo
The three primary sites of acute T-cell mediated rejection (TCMR) in transplanted kidneys are the tubular epithelial cells, interstitum, and the vascular endothelial cells. The pathology of acute lesions is characterized by inflammatory cell infiltration; the final diagnosis suggested by the Banff 2019 classification is guided by grading of tubulitis (the t-score), interstitial inflammation (the i
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Thin Basement Membrane: An Underrated Cause of End-Stage Renal Disease Nephron (IF 2.5) Pub Date : 2023-03-07 Martina Uzzo, Gabriella Moroni, Claudio Ponticelli
The term “thin basement membrane” (TBM) refers to a glomerular disorder characterized by diffuse uniform thinning of the glomerular basement membrane (GBM) on electron microscopy. Patients with TBM usually show an isolated hematuria with excellent renal prognosis. However, some patients can develop proteinuria and progressive kidney dysfunction in the long term. Most patients with TBM are heterozygous
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Bartter Syndrome-Related Variants Distribution: Brazilian Data and Its Comparison with Worldwide Cohorts Nephron (IF 2.5) Pub Date : 2023-03-07
Background: Genetic testing is recommended for accurate diagnosis of Bartter syndrome (BS) and serves as a basis for implementing specific target therapies. However, populations other than Europeans and North Americans are underrepresented in most databases and there are uncertainties in the genotype-phenotype correlation. We studied Brazilian BS patients, an admixed population with diverse ancestry
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Identification of a splicing variant c.3813-3A>G in NPHP3 by reanalysis of whole exome sequencing in a Chinese boy with nephronophthisis Nephron (IF 2.5) Pub Date : 2023-03-06 Xinjie Zhang, Xiufang Zhi, Xin Wang, Yan Dong, Jianbo Shu, Wenhong Wang, Chunquan Cai
Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular injury and commonly results in kidney failure. We reported a case of 4-year-old Chinese boy presented with severe anemia, kidney and liver dysfunction. Whole exome sequencing (WES) was performed to identify the candidate variant with a negative result initially. After complete collection of clinical information
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Light chain deposition disease recurrence in renal allograft after long-term remission Nephron (IF 2.5) Pub Date : 2023-02-21 Azusa Kobayashi, Asami Takeda, Hibiki Shinjo, Daiki Iguchi, Chiharu Ito, Eriko Okada, Norihiko Goto, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Shunji Narumi, Yoshihiko Watarai
Light chain deposition disease (LCDD) is a rare manifestation of monoclonal gammopathy, which can lead to renal failure. We previously reported a detailed recurrence process in a case of LCDD after renal transplantation. To the best of our knowledge, no report has described the long-term clinical course and renal pathology findings of recurrent LCDD in patients after renal transplantation. In this
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Leptospirosis: A Potential Culprit for Chronic Kidney Disease of Uncertain Etiology Nephron (IF 2.5) Pub Date : 2023-02-21 Shakila Sudarshani Premarathne, Chandika Gamage, Rohana Chandrajith, Neelakanthi Vajira Ratnatunge, Sulochana Wijetunge, Abdul Wazil, Li-Fang Chou, Yi-Ching Ko, Chiung-Tseng Huang, Huang-Yu Yang, Amanda Fonseka, Thamalu Sonnadara, Dulanjali Herath, Pasan Hewavitharane, Chih-Wei Yang, Nishantha Nanayakkara
Purpose: Chronic kidney disease of uncertain etiology (CKDu) is an environmental nephropathy in which the etiological factors are yet uncertain. Leptospirosis, a spirochetal infection that is common among agricultural communities, has been identified as a potential etiology for CKDu beyond environmental nephropathy. Although CKDu is a chronic kidney disease, in endemic regions, an increasing number
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Clinicopathological features of Gitelman syndrome with proteinuria and renal dysfunction Nephron (IF 2.5) Pub Date : 2023-02-20
Introduction. Gitelman syndrome (GS) is a rare renal tubular salt-wasting disorder. Besides kidney electrolytes loss, proteinuria and renal dysfunction were also observed. However, their incidence, risk factors, pathological features, and prognosis were unclear. Methods. We retrospectively reviewed 116 GS patients and analyzed their clinical, genetic, and pathological characteristics. We also systematically
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Serum potassium trajectory during AKI and mortality risk Nephron (IF 2.5) Pub Date : 2023-02-17 Jonathan S. Chávez-Íñiguez, Pablo Maggiani-Aguilera, Andrés Aranda-García de Quevedo, Rolando Claure-Del Granado, Olynka Vega-Vega, Salvador R. Lopez-Giacoman, Gael Chávez-Alonso, Ana E. Oliva-Martínez, Bladimir Díaz-Villavicencio, Clementina E. Calderón-García, David González-Barajas, Manuel Arizaga-Nápoles, Frida M. De la Vega-Méndez, Guillermo Navarro-Blackaller, Ramón Medina-González, Margarita
Background: The association between potassium (sK) level trajectory and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored. Methods: In this prospective cohort, AKI patients admitted to the Hospital Civil de Guadalajara were enrolled. Eight groups based on the sK (mEq/L) level trajectories during 10 days of hospitalization were
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The clinicopathologic spectrum of membranous nephropathy with lupus-like features Nephron (IF 2.5) Pub Date : 2023-02-06 Hae Yoon Grace Choung, Catherine Moore, Thu H. Le, Paul Guirguis, Jack M McKeown, Jerome Jean-Gilles, Bruce Goldman
Introduction: The pathologic features of membranous lupus nephritis (MLN) are occasionally encountered in secondary membranous nephropathy (sMN) without overt clinical evidence of SLE. Moreover, some sMN with lupus-like features (LL-MN) have a clinical presentation more typical of primary membranous nephropathy (pMN). Based on the confounding clinical and pathologic presentation, it is unclear how
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CO-OCCURRENCE OF NEPHRONOPHTHISIS TYPE 1 AND ALSTRÖM SYNDROME: A CASE REPORT. Nephron (IF 2.5) Pub Date : 2023-02-06
We describe the unique case of a patient in whom two ciliopathies with autosomal recessive transmission were clinically and molecularly diagnosed: Nephronophthisis type1 (NPHP1) and Alström Syndrome (AS). NPHP1 is one of the main genetic causes of terminal kidney failure in childhood. AS is an ultra-rare multi-systemic disease, characterized by progressive kidney disease, hepatic failure, dystrophy
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THE CARDINAL TRIAL OF BARDOXOLONE METHYL IN ALPORT SYNDROME: WHEN MARKETING INTERESTS PREVAIL OVER PATIENTS CLINICAL NEEDS Nephron (IF 2.5) Pub Date : 2023-02-02
Context. Alport syndrome (AS) is a hereditary chronic kidney disease (CKD) with X-linked, autosomal and digenic patterns of transmission. Sieving dysfunction of the glomerular basement membrane caused by congenitally defective type IV collagen results in persistent proteinuria, hematuria and progressive renal dysfunction. There are no disease-specific medications and treatment is based on conservative
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Association between hypokalemia and albuminuria in a Japanese general population Nephron (IF 2.5) Pub Date : 2023-02-01 Akiko Toda, Shigeko Hara, Ritsuko Honda, Yasuji Arase
Introduction: Hypokalemia is associated with an increased risk of chronic kidney disease (CKD) and is a risk factor for mortality. Albuminuria is an early manifestation of CKD. We investigated the association between hypokalemia and the prevalence of albuminuria in a Japanese general population. Methods: We analyzed the data of 18,289 subjects who underwent annual health checkups in 2018. We categorized
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Piceatannol protects against high glucose-induced injury of renal tubular epithelial cells via regulating carbonic anhydrase 2 Nephron (IF 2.5) Pub Date : 2023-01-30 Xin Zhang, Qian Wang, Fagen Li, Suna Li, Hepu Lin, Yanhong Huo
Introduction: We here evaluated the efficacy of piceatannol (PIC) in high glucose (HG)-induced injury of renal tubular epithelial cells HK-2. Methods: After the establishment of HG-induced cell injury model and the treatment with PIC at both high and low concentrations and/or Acetazolamide (ACZ, the inhibitor of carbonic anhydrase 2 (CA2)), MTT and flow cytometry assays were carried out to confirm
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Peripheral Eosinophil Count Associated with Disease Activity and Clinical Outcomes in Hospitalized Patients with Lupus Nephritis Nephron (IF 2.5) Pub Date : 2023-01-19 Ruihua Liu, Yuan Peng, Hongjian Ye, Xi Xia, Wei Chen, Fengxian Huang, Zhijian Li, Xiao Yang
Introduction: The aim of this study was to evaluate the association of peripheral eosinophil (EOS) count with disease activity and kidney outcomes in lupus nephritis (LN) patients. Methods: A total of 453 hospitalized and biopsy-proven LN patients at our hospital from 2006 to 2013 were enrolled, of which 388 patients had repeated measurements of EOS. Relationships were explored between average EOS
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The Clinical and Mutational Spectrum of 69 Turkish Children with Autosomal Recessive or Autosomal Dominant Polycystic Kidney Disease: A Multicenter Retrospective Cohort Study Nephron (IF 2.5) Pub Date : 2023-01-19 Ozum Tutal, Bora Gulhan, Emine Atayar, Selcuk Yuksel, Z. Birsin Ozcakar, Oguz Soylemezoglu, Seha Saygili, Salim Caliskan, Mihriban Inozu, Esra Baskin, Ali Duzova, Mutlu Hayran, Rezan Topaloglu, Fatih Ozaltin
Introduction: Autosomal recessive polycystic kidney disease (ARPKD) is associated with pathogenic variants in the PKHD1 gene. Autosomal dominant polycystic kidney disease (ADPKD) is mainly associated with pathogenic variants in PKD1 or PKD2. The present study aimed to identify the clinical and genetic features of Turkish pediatric ARPKD and ADPKD patients. Methods: This multicenter, retrospective cohort
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Functional characterization of renal tubular epithelial cells in optimized co-culture systems Nephron (IF 2.5) Pub Date : 2023-01-17
Background: Obtaining sufficient renal tubular epithelial cells (RTCs) and maintaining the functions of RTCs are vital for developing a bioartificial renal tubule-assisted device for continuous renal replacement therapy. Methods: We established an optimal Transwell co-culture system using human primary renal proximal tubule epithelial cells (RPTECs) and bone marrow mesenchymal stem cells (BMMSCs) at
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Kidney Disease and Viral Infection in COVID-19: Why Are Kidney Organoid and Biopsy Studies Not in Agreement? Nephron (IF 2.5) Pub Date : 2023-01-17
Context: The clinical course of coronavirus disease-19 (COVID-19) can be complicated by acute kidney injury and proteinuria. Kidney cells express receptors for SARS-CoV-2, the virus responsible for COVID-19. Direct infection of the kidney parenchyma by SARS-CoV-2 has been proposed as the cause of renal dysfunction in COVID-19. Subject of Review: Kidney organoids derived from human embryonic stem cells
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Age-Dependent Effects of Acute Kidney Injury on End-Stage Kidney Disease and Mortality in Patients with Moderate to Severe Chronic Kidney Disease Nephron (IF 2.5) Pub Date : 2023-01-17 Yu-Hsiang Chou, Tai-Shuan Lai, Yi-Chih Lin, Wen-Chih Chiang, Tzong-Shinn Chu, Shuei-Liong Lin, Yung-Ming Chen
Introduction: Old age has been considered as a positive modifier of chronic kidney disease (CKD), but the progression of CKD is often accelerated by acute kidney injury (AKI) in older adults. This study aimed to investigate this paradoxical interplay and identify age-specific predictors of end-stage kidney disease (ESKD). Methods: This retrospective cohort included 6,101 patients with CKD stage 3B-5
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Effect of Orthostatic Hypotension on Kidney Function Nephron (IF 2.5) Pub Date : 2023-01-17 Jin Hee Na, Sung Rok Kim, Yu-Ji Lee
Background: The association between orthostatic hypotension (OH) and long-term changes in kidney function in the general population is not yet well known. Methods: We performed a population-based cohort study based on data from the Korean Genome and Epidemiology Study (KoGES). The primary exposure was the presence of classic OH, defined as a postural drop in blood pressure (systolic blood pressure
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A Study on the CLCN5 Gene in Iranian Patients: A Report of Novel and Recurrent Mutations Nephron (IF 2.5) Pub Date : 2023-01-16 Ali Mollataheri, Marzieh Mojbafan, Rozita Hosseini, Nakisa Houman, Mohammad Mousavi, Hasan Otoukesh
Introduction: Dent’s disease is an X-linked inherited renal tubular disorder characterized by proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, rickets, and end-stage renal disease. Almost 60% of patients have causative mutations in the CLCN5 gene (Dent 1), and 15% of affected individuals have mutations in the OCRL1 gene (Dent 2). The aims of this study are to identify CLCN5 mutations
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Proceedings of the 12th Annual UAB-UCSD O’Brien Center Symposium: Changing Paradigms in Acute Kidney Injury – From Mechanisms to Management Nephron (IF 2.5) Pub Date : 2023-01-12 Monica Vasiliu
Nephron
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CYP3A5 Expressor Genotype of the Transplanted Kidney Increases the Risk of Preterm Graft Loss and Acute Rejection Nephron (IF 2.5) Pub Date : 2023-01-11 Karola Warzyszyńska, Michał Zawistowski, Edyta Karpeta, Agnieszka Jałbrzykowska, Maciej Kosieradzki
Introduction: Tacrolimus is metabolized mainly in the liver by the CYP3A enzyme family, with a particularly well-documented role of CYP3A5. CYP3A5 is also expressed in the renal tissue and is present in the transplanted kidney. To date, the association between donor CYP3A5 polymorphisms and transplant outcome remains poorly understood. The aim of this study was to assess the effect of donor CYP3A5
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Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes and Chronic Kidney Disease Nephron (IF 2.5) Pub Date : 2023-01-11
Background: Nonalcoholic fatty liver disease (NAFLD) is suggested as a risk factor for chronic kidney disease (CKD). The incidence of NAFLD is rising globally in parallel to the increasing incidences of obesity and type 2 diabetes. Diabetes remains the leading cause of CKD, but the co-existence of NAFLD, CKD, and type 2 diabetes is not well elucidated. Here, we evaluated the prevalence of NAFLD in
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Suspected Autosomal Recessive Polycystic Kidney Disease but Cerebellar Vermis Hypoplasia, Oligophrenia Ataxia, Coloboma, and Hepatic Fibrosis (COACH) Syndrome in Retrospect, A Delayed Diagnosis Aided by Genotyping and Reverse Phenotyping: A Case Report and A Review of the Literature Nephron (IF 2.5) Pub Date : 2023-01-06 Meenakshi Sambharia, Margaret E. Freese, Francisco Donato, Girish Bathla, Ibrahim M.M. Abukhiran, Maisie I. Dantuma, M. Adela Mansilla, Christie P. Thomas
The clinical features of cerebellar vermis hypoplasia, oligophrenia, ataxia, coloboma, and hepatic fibrosis (COACH) characterize the rare autosomal recessive multisystem disorder called COACH syndrome. COACH syndrome belongs to the spectrum of Joubert syndrome and related disorders (JSRDs) and liver involvement distinguishes COACH syndrome from the rest of the JSRD spectrum. Developmental delay and
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Racial and Ethnic Differences in Chronic Kidney Disease and Its Risk Factors among Asian-Americans and Pacific Islanders in Hawaii Nephron (IF 2.5) Pub Date : 2023-01-05 Connie M. Rhee, Amy S. You, Victoria Page, Glen Hayashida, Merle Kataoka-Yahiro, James Davis, Linda L. Wong, Yoko Narasaki, Kamyar Kalantar-Zadeh
Background: Several studies suggest that Asian-American and Native Hawaiian and Other Pacific Islander (NHOPI) racial/ethnic groups have a heightened risk of chronic kidney disease (CKD), but provide limited inference due to the aggregation of these groups into a single racial/ethnic category. We thus examined the association of granularly defined racial/ethnic groups with specific CKD indicators among
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Humoral Response to BNT162b2 and CoronaVac in Patients Undergoing Maintenance Hemodialysis: A Multicenter Prospective Cohort Study Nephron (IF 2.5) Pub Date : 2023-01-05 Safak Mirioglu, Rumeyza Kazancioglu, Egemen Cebeci, Necmi Eren, Tamer Sakaci, Selma Alagoz, Murat Tugcu, Serhan Tuglular, Bilge Sumbul, Nurhan Seyahi, Savas Ozturk
Introduction: Data regarding inactivated vaccines for SARS-CoV-2 in patients undergoing maintenance hemodialysis (MHD) are limited. We aimed to investigate humoral responses induced by CoronaVac compared to BNT162b2 in this population. Methods: In this multicenter prospective cohort study, adult patients undergoing MHD who lacked a history of COVID-19 and decided to get vaccinated with BNT162b2 or
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Neuronal Proteins as Antigenic Targets in Membranous Nephropathy Nephron (IF 2.5) Pub Date : 2022-12-29
Context: The discovery of new target antigens in membranous nephropathy (MN) has revealed new disease phenotypes and, in some cases, has suggested mechanisms of disease shared by two concurrent autoimmune diseases. Subject of Review: Several recent reports and an accompanying editorial describe the association of anti-contactin-1 (CNTN1) autoantibodies of the IgG4 subclass with a novel subtype of MN
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A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics Nephron (IF 2.5) Pub Date : 2022-12-29 Sandrine Placier, Anxiang Cai, Liliane Louedec, Perrine Frère, Souhila Ouchelouche, Christos Chatziantoniou, Amélie Calmont
Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown. Objectives: The objective of the study
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Haemolytic Uremic Syndrome: A Study Cohort over 10-Year Period in a Paediatric Tertiary Centre Hospital Nephron (IF 2.5) Pub Date : 2022-12-21
Background: Haemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by haemolytic anaemia, thrombocytopenia, and acute kidney injury. It represents the most frequent cause of acute kidney failure in paediatric age. HUS includes acquired types, such as post-infectious forms, and inherited types. If not promptly recognized, HUS still has high mortality and morbidity, with disabling
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Renal Histology in CKD Stages: Match or Mismatch with Glomerular Filtration Rate? Nephron (IF 2.5) Pub Date : 2022-12-16 Francesco Trevisani, Matteo Floris, Alessandra Cinque, Arianna Bettiga, Giacomo Dell’Antonio
A reliable assessment of renal function is of paramount importance in several clinical assets in order to tailor a personalized medical approach. CKD classification system, created in 2002 by the National Kidney Foundation-sponsored Kidney Disease Outcomes Quality Initiative and then implemented in the following years by the K-DIGO guidelines, offered clinicians a new strategy to better identify nephrological
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Association of Sleep Duration with Physical Performance in Hemodialysis Patients: A Multicenter Cross-Sectional Study Nephron (IF 2.5) Pub Date : 2022-11-29 Qiunan Zhan, Junli Zhao, Qi Guo, Jianying Niu, Chen Yu, Wei Ding, Liming Zhang, Hualin Qi, Xiang Shao
Background: Hemodialysis (HD) patients have decreased physical function. Getting enough sleep is important for maintaining physical function. However, the relationship between sleep duration and physical performance in HD patients is unclear. Methods: We conducted a multicenter cross-sectional study at seven HD centers in Shanghai and Suzhou, China. 880 HD patients were enrolled between July 2020 and
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Collagen IV and Podocyte-Related Gene Variants in Patients with Concurrent IgA Nephropathy and Thin Basement Membrane Nephropathy Nephron (IF 2.5) Pub Date : 2022-11-08 Hua Xu, XueWen Yu, Yun Li, ZhongHua Huang, Lu Zhang, QinQin Min, JiaXin Bi, ZhenGuo Li, LingYun Liu, YingYing Liang, ZhouWen Xu, HuiLi Sun, ShuDong Yang, MuMin Shao
Introduction: IgA nephropathy is the most common primary glomerulonephritis among adults in clinic. Thin basement membrane nephropathy is often underestimated or even omitted if it coincides with IgA nephropathy. Therefore, it is necessary to study the epidemiological, clinical, and molecular characteristics of the concurrence of this entity. Methods: Eight patients with concurrent IgA nephropathy
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Reprogramming Metabolism to Enhance Kidney Tolerance during Sepsis: The Role of Fatty Acid Oxidation, Aerobic Glycolysis, and Epithelial De-Differentiation Nephron (IF 2.5) Pub Date : 2022-11-04 Hernando Gómez
Background: The recognition that sepsis induces acute kidney injury (AKI) in the absence of overt necrosis or apoptosis and even in the presence of increased renal blood flow has led to the consideration that kidney tubular epithelial cells (TECs) may deploy defense mechanisms to survive the insult. Summary: This concept dovetails well with the notion that the defense against infection not only depends
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A Pathogenic Variant of PBX1 Identified by Whole Exome Sequencing in a Chinese CAKUTHED Case Nephron (IF 2.5) Pub Date : 2022-11-01 Ling Nie, Yan Li, Tangli Xiao, Bo Zhang, Jinghong Zhao, Weiping Hou
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (CAKUTHED) is a rare autosomal dominant disorder and variants in PBX1 are involved in the etiology of this syndrome. Precise diagnosis is difficult without genetic test. We described a Chinese CAKUTHED patient, whose characteristics were collected from medical records. The potential
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Modeling Low Muscle Mass Screening in Hemodialysis Patients Nephron (IF 2.5) Pub Date : 2022-10-21 Daiki Senzaki, Nobuo Yoshioka, Osamu Nagakawa, Emi Inayama, Takafumi Nakagawa, Hidehito Takayama, Toko Endo, Fumitaka Nakajima, Masayoshi Fukui, Yasuaki Kijima, Yasuo Oyama, Risshi Kudo, Tadashi Toyama, Yosuke Yamada, Kiyoshi Tsurusaki, Naoki Aoyama, Takayasu Matsumura, Hideki Yamahara, Kenro Miyasato, Tetsuya Kitamura, Tatsuyoshi Ikenoue
Introduction: Computed tomography (CT) can accurately measure muscle mass, which is necessary for diagnosing sarcopenia, even in dialysis patients. However, CT-based screening for such patients is challenging, especially considering the availability of equipment within dialysis facilities. We therefore aimed to develop a bedside prediction model for low muscle mass, defined by the psoas muscle mass
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Responses in Blood Pressure and Kidney Function to Soluble Guanylyl Cyclase Stimulation or Activation in Normal and Diabetic Rats Nephron (IF 2.5) Pub Date : 2022-10-20 Rohit Patel, Yiling Fu, Ser Khang, Agnes M. Benardeau, Scott C. Thomson, Volker Vallon
Introduction: Agonists of soluble guanylate cyclase (sGC) are being developed as treatment for cardiovascular disease. Most effects of nitric oxide (NO) on glomerular and tubular function are mediated through sGC, but whether sGC agonists mimic these effects is unknown. Methods: Renal clearance and micropuncture studies were performed in Wistar-Froemter rats (WF), with or without streptozotocin diabetes
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Acceptance of Illness, Satisfaction with Life, and Emotional Control in the Early Stage of Autosomal Dominant Polycystic Kidney Disease Nephron (IF 2.5) Pub Date : 2022-10-12 Magdalena Jankowska, Anna Walerzak, Michał Harciarek, Bolesław Rutkowski, Alicja Dębska-Ślizień
Introduction: Psychological disorders are strong predictors of life expectancy and have an impact on quality of life. Autosomal dominant polycystic kidney disease (ADPKD) is frequently diagnosed before the onset of subjective symptoms. Similar to other disorders of genetic origin, ADPKD may be a source of remarkable psychological discomfort. One way of coping with emotional distress is its suppression
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NEK8-Associated Nephropathies: Do Autosomal Dominant Forms Exist? Nephron (IF 2.5) Pub Date : 2022-10-10 Cybel Mehawej, Eliane Chouery, Ramy Ghabril, Sima Tokajian, Andre Megarbane
Introduction: Nephronophthisis (NPHP) is a group of autosomal recessive renal diseases characterized by a reduced ability of the kidneys to concentrate solutes, chronic tubulointerstitial nephritis, and cystic kidney disease. It represents the most common genetic cause of childhood renal failure. To date, around 20 different genes, encoding primary cilia proteins, have been linked to NPHP. These contribute
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Intestinal Microbiota in Experimental Acute Kidney Injury Nephron (IF 2.5) Pub Date : 2022-10-04 Neal Shah, Hamid Rabb
Recent studies have demonstrated an important role played by gut microbiota in maintaining intestinal homeostasis and host immune system function. Gut microbiota have been studied in experimental acute kidney injury (AKI) using different mice and rat models exposed to either ischemia or cisplatin-mediated tubular injury. Differences in inflammatory markers and severity of AKI have been observed between
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Evaluation of Outcomes of Peritoneal Dialysis Patients in the Post-COVID-19 Period: A National Multicenter Case-Control Study from Turkey Nephron (IF 2.5) Pub Date : 2022-09-30 Savas Ozturk, Meltem Gursu, Mustafa Arici, Idris Sahin, Necmi Eren, Murvet Yilmaz, Sumeyra Koyuncu, Semahat Karahisar Sirali, Zeynep Ural, Belda Dursun, Enver Yuksel, Sami Uzun, Savaş Sipahi, Elbis Ahbap, Halil Yazici, Orcun Altunoren, Onur Tunca, Yavuz Ayar, Ebru Gok Oguz, Zulfukar Yilmaz, Serdar Kahvecioglu, Ebru Asicioglu, Aysegul Oruc, Rezzan Ataman, Zeki Aydin, Bulent Huddam, Murside Esra Dolarslan
Introduction: There are not enough data on the post-COVID-19 period for peritoneal dialysis (PD) patients affected from COVID-19. We aimed to compare the clinical and laboratory data of PD patients after COVID-19 with a control PD group. Methods: This study, supported by the Turkish Society of Nephrology, is a national, multicenter retrospective case-control study involving adult PD patients with
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Extracellular Vesicles in Acute Kidney Injury Nephron (IF 2.5) Pub Date : 2022-09-30 Hayrettin Yavuz, Max M. Weder, Uta Erdbrügger
Extracellular vesicles (EVs) are promising novel cellular communicators and biomarkers in acute kidney injury (AKI). These submicron vesicles derive from all cell types along the urinary tract and reflect molecular processes of their parent cells and physiological and pathological conditions in AKI. Several EV protein and RNA biomarker candidates have been identified. They have shown to differentiate
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A Fabry Disease Patient Who Developed Hypersensitivity Reaction against Agalsidase Beta following COVID-19 Infection Nephron (IF 2.5) Pub Date : 2022-09-29 Ozge Sonmez, Seyda Gul Ozcan, Sinan Trabulus, Nurhan Seyahi
Fabry disease (FD) is a rare, X-linked inherited lysosomal storage disorder, characterized by the accumulation of globotriaosylceramide (Gb3) due to the deficiency or absence of alpha-galactosidase A. Due to the accumulation of Gb3, cardiac, renal, neurological, and skin manifestations can be observed. Enzyme replacement therapy (ERT) with agalsidase alfa or agalsidase beta is the cornerstone in the
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Impact of Potentially Inappropriate Medications on Kidney Function in Chronic Kidney Disease: Retrospective Cohort Study Nephron (IF 2.5) Pub Date : 2022-09-16 Hiroshi Kimura, Satomi Yoshida, Masato Takeuchi, Koji Kawakami
Introduction: Chronic kidney disease (CKD) represents a major public health burden. Potential inappropriate medications (PIMs) are common in patients with CKD. However, its impact on kidney outcomes has not been adequately elucidated for middle-aged patients. This study aimed to clarify the prescription status of PIMs for middle-aged patients with CKD and its effect on kidney function decline. Methods:
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Targeting Endoplasmic Reticulum for Novel Therapeutics and Monitoring in Acute Kidney Injury Nephron (IF 2.5) Pub Date : 2022-09-16 Chuang Li, Siva Krothapalli, Ying Maggie Chen
Background: Endoplasmic reticulum (ER) stress response is a conservative mechanism involving a complex network of different molecular branches to determine cell fate through specific transcription factors and downstream executors. Emerging evidence shows that ER stress is implicated in the occurrence and progression of acute kidney injury (AKI) in different animal models and human patients. However
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Acute Kidney Injury and Diastolic Dysfunction: Opportunity for Targeted Intervention? Nephron (IF 2.5) Pub Date : 2022-09-15 Danielle E. Soranno, Katja M. Gist
Background/Aims: Acute kidney injury (AKI) is common, results in nonrenal sequelae, and predisposes patients to long-term cardiovascular disease. The long-term systemic effects of AKI remain unclear. Sex is an important biological variable in ischemia-reperfusion AKI, and the protective role of estrogen has stymied the inclusion of both sexes in preclinical AKI studies. ITF2357 is a nonspecific histone
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Myeloid Response to Acute Kidney Injury Nephron (IF 2.5) Pub Date : 2022-09-15 William T. Nash, Marissa S. Yee, Mark D. Okusa
Background: Myeloid cells form an important element of the response to ischemia-reperfusion injury (IRI). While the mononuclear phagocyte system is complex and difficult to study, our knowledge of the cells involved and their impacts has been steadily increasing. However, there is still need to rigorously define and separate the functions of discreet myeloid populations in the kidney. The relatively
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Hypotension at Hospital Presentation and Post-Contrast Acute Kidney Injury following Computed Tomography with Contrast Media Nephron (IF 2.5) Pub Date : 2022-09-12 Jo Yoshizawa, Ryo Yamamoto, Koichiro Homma, Hanae Kamikura, Kazuhiko Sekine, Yosuke Kobayashi, Tomohiro Funabiki, Junichi Sasaki
Introduction: Post-contrast acute kidney injury (PC-AKI) is a major complication of contrast media usage; risks for PC-AKI are generally evaluated before computed tomography (CT) with contrast at the emergency department (ED). Although persistent hypotension (systolic blood pressure [sBP] #x3c;80 mm Hg for 1 h) is associated with increased PC-AKI incidence, it remains unclear whether transient hypotension
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Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System Nephron (IF 2.5) Pub Date : 2022-09-12 Sandra Hummelgaard, Kathrin Weyer
The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from the glomerular ultrafiltrate. All major RAS components are present in the kidney proximal tubules. Here, megalin drives endocytosis of angiotensinogen (AGT), prorenin
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Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement Nephron (IF 2.5) Pub Date : 2022-09-12 Catarina Oliveira-Silva, Nídia Marques, Ana Pinho, Rui Poínhos, Rui Bergantim, Ana Teresa Nunes, Susana Sampaio, Pedro Rodrigues-Pereira, Roberto Silva, Augusta Praça, João Frazão, Manuel Pestana, Isabel Tavares
Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown. Methods: This retrospective cohort study evaluated patients with renal biopsy-proven amyloidosis, diagnosed from January 1978 to December 2019. Follow-up started at kidney disease presentation and ended at death or August 2020. Clinical presentation
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Drug-Induced Acute Kidney Injury Risk Prediction Models Nephron (IF 2.5) Pub Date : 2022-09-09 Zaid Yousif, Linda Awdishu
Background: Acute kidney injury (AKI) risk prediction models can predict AKI with short lead times and excellent model performance. However, these prediction models have not ascertained the etiology of the AKI. Drugs are an important contributor to AKI, and it is difficult to distinguish drug causes from other etiologies. Summary: Clinical adjudication of AKI etiology can reduce misclassification associated