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Bone Mineral Parameters in Peritoneal Dialysis Patients after Lowering Calcium Concentration in Dialysis Fluids: A Case Series in Patients Using Icodextrin. Case Rep. Nephrol. Dial. Pub Date : 2023-11-08 Lara C Verschuur,Anouschka G Liefting,Bastiaan van Dam,Erik L Penne,Fenneke C Frerichs
In patients treated with peritoneal dialysis (PD), lowering the calcium level in PD fluids results in lower serum calcium levels and higher parathyroid hormone (PTH) levels. It is hypothesized that this effect is attenuated when patients are using icodextrin 7.5% for the once-daily long dwell (containing high calcium concentration). In this case series, we included 8 stable PD patients (mean age 68
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Multi-Organ Relapse following COVID-19 in Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-10-25 Won-Hee Cho,Seo Yeon Hwang,Sun Ryoung Choi,Biro Kim,Joune Seoup Lee,Dong Gun Lee,Hyun Soon Lee
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complex systemic autoimmune disease characterized by small vessel vasculitis. Typically, the relapse rate is lower in patients with end-stage kidney disease (ESKD) than in those with chronic kidney disease, prior to dialysis. Here, we report a rare case of multi-organ relapse in a patient with myeloperoxidase (MPO)-AAV who
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Three Pediatric Patients with Congenital Nephrogenic Diabetes Insipidus due to AVPR2 Nonsense Mutations and Different Clinical Manifestations: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-10-18 Hijiri Watanabe,Hiroshi Tamura,Keishiro Furuie,Shohei Kuraoka,Hitoshi Nakazato
Congenital nephrogenic diabetes insipidus (CNDI), a rare hereditary disorder, is characterized by the inability of the kidneys to concentrate urine in response to the antidiuretic hormone arginine vasopressin (AVP); as a result, large volumes of unconcentrated urine are excreted. In addition to the clinical manifestations of CNDI, such as dehydration and electrolyte disturbances (hypernatremia and
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Venous Excess Doppler Ultrasound: A Visual Guide to Decongestion in Cardiorenal Syndrome. Case Rep. Nephrol. Dial. Pub Date : 2023-10-06 Sirisha Gudlawar,Abhilash Koratala
Promptly recognizing congestion, both clinical and hemodynamic, is paramount in the management of patients with heart failure. The pathophysiology of congestion involves a complex interplay of absolute fluid gain, volume redistribution from venous capacitance beds to the central venous circulation, inadequate excretion due to renal dysfunction, salt and water retention, and endothelial dysfunction
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Novel LAGE3 Pathogenic Variants Combined with TRPC6 and NUP160 Variants in Galloway-Mowat Syndrome: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-09-25 Limin Huang,Xiaojing Zhang,Yingying Zhang,Yanfei Wang,Jianhua Mao
Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies in children. Researchers studying GAMOS reported the first pathogenic variant identified was the WDR73 gene, and more recently, four new pathogenic genes, OSGEP, LAGE3, TP53RK, and TPRKB, have been identified. In the present study, we report a
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Catheter-Related Bloodstream Infection in Hemodialysis Patient due to Atlantibacter hermannii. Case Rep. Nephrol. Dial. Pub Date : 2023-09-20 Preslava M Hristova,Alexandra S Alexandrova,Martin Lucanov,Hristina Y Hitkova,Biser Kirilov Borisov
Atlantibacter hermannii, previously known as Escherichia hermannii, is a rare causative agent of human infections. Several reports testify that the most frequently infected patients are immunosuppressed, especially those undergoing hemodialysis. A 34-year-old man with an end-stage renal disease complained of chills, fever, and general fatigue at the end of a regular hemodialysis session. The echocardiographic
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First Reported Case of a Pyrophosphate Kidney Stone in a Human. Case Rep. Nephrol. Dial. Pub Date : 2023-09-18 Michael R Gigax,Lee Yang,Glenn Austin,Neil S Mandel,Jody P Lulich,John R Asplin
Urolithiasis composed of pyrophosphate salts has only been reported in animals, in the form of potassium magnesium pyrophosphate. However, there have been no reports of pyrophosphate stones in humans. Hypophosphatasia is an inherited disease characterized by low alkaline phosphatase activity and elevated levels of pyrophosphate in blood and urine. Urolithiasis is a part of the hypophosphatasia phenotype
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A Novel Mutation of UMOD in a Chinese Family with IgA Nephropathy: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-08-17 Furong Li,Huan Zou,Li Liu,Tangli Xiao,Bo Zhang,Jun Zhang
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with varying clinical presentations. The hereditary susceptibility to IgAN is rather complex. In this report, a Chinese case of IgAN was recruited. Renal biopsy showed the tubular atrophy and dilatation, but the glomerular lesions were rather weak except slight mesangial hyperplasia. Immunological staining of kidney
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A Case of Mesangial Proliferative Nephritis Caused by Slow Cryoglobulin. Case Rep. Nephrol. Dial. Pub Date : 2023-08-14 Seiji Hashimoto,Nobuhiko Okamoto,Tomochika Maoka,Rie Yamamoto,Shinichi Araki,Akira Suzuki,Yuichiro Fukasawa,Takao Koike
The patient was a woman in her 60s. She was found to have proteinuria on a health checkup. She did not have any particular subjective symptoms, and no definitive diagnosis was made, despite serological findings indicative of immune abnormalities. A renal biopsy was performed. Light microscopy of renal tissue section revealed mesangial proliferative nephritis. Electron microscopic findings included
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Campylobacter Colitis as a Trigger for Atypical Hemolytic Uremic Syndrome: About One Case. Case Rep. Nephrol. Dial. Pub Date : 2023-08-14 Thomas Quinaux,Zead Tubail,Isabelle Vrillon,Hervé Sartelet,Benjamin Savenkoff
We present the case of a 17-year-old Caucasian male whose condition featured acute renal failure, anemia, and deep thrombocytopenia after five consecutive days of diarrhea. Campylobacter coli was identified in stool cultures and, although the direct role of this germ in the pathogenesis of hemolytic uremic syndrome (HUS) remains uncertain to this day, initial presentation was considered broadly consistent
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A Case of Rapidly Progressive Diabetic Nephropathy Induced by Osimertinib. Case Rep. Nephrol. Dial. Pub Date : 2023-08-08 Kazunori Karasawa,Ken-Ichi Akiyama,Taro Akihisa,Yoei Miyabe,Kosaku Nitta,Junichi Hoshino
The number of patients with diabetic nephropathy is increasing worldwide and it is important to understand the underlying pathological mechanisms of the disease. In early stage diabetic nephropathy, the hyperglycemic environment leads to vascular endothelial cell damage, resulting in overexpression of vascular endothelial growth factor (VEGF) in podocytes and renal pathology of glomerular hypertrophy
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Conversion from Intermittent Hemodialysis to Peritoneal Dialysis in Metastatic Catheter-Related Bloodstream Infection. Case Rep. Nephrol. Dial. Pub Date : 2023-08-08 Mohamedanwar Ghandour,Ravi K Thimmisetty,James Sondheimer,Nashat Imran,Zeenat Y Bhat,Yahya Mohamed Osman-Malik
Of all complications from central venous catheters (CVC) in end-stage renal disease (ESRD) patients, catheter-related bloodstream infection (CRBSI) is one of the most devastating consequences. The option of catheter salvage is not an effective measure with metastatic infections. However, in patients with severe vasculopathy and/or near end-stage vascular disease, preservation of the venous access should
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Chryseobacterium indologenes Peritonitis in a Peritoneal Dialysis Patient: A Case Report and Review of Literature. Case Rep. Nephrol. Dial. Pub Date : 2023-08-04 Akira Miyakawa,Kentaro Fujii,Ai Kato,Wataru Sugi,Ayumi Yoshifuji,Motoaki Komatsu,Munekazu Ryuzaki
Peritonitis is one of the most important complications in patients with peritoneal dialysis (PD). Appropriate antibiotic treatment against PD-associated peritonitis is necessary to prevent PD catheter removal and withdrawal from PD. Chryseobacterium indologenes is a Gram-negative rod that occurs in the natural environment. C. indologenes is thought to acquire resistance to β-lactam drugs through the
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Severe Clozapine Poisoning Treated by Extracorporeal Blood Purification Therapy. Case Rep. Nephrol. Dial. Pub Date : 2023-07-27 Andreas Hartjes,Matthäus Machnik,Christa Kubasta,Karl Schrattbauer
Clozapine is a frequently used antipsychotic that, in case of overdose, can cause severe adverse side effects, such as hematological, cardiovascular, and neurological complications. As there is no specific antidote or reversal agent available, extracorporeal techniques such as CytoSorb hemoadsorption might represent a viable option, having already been used in a variety of intoxication scenarios with
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Nephropathy in a Child with Severe Recessive Dystrophic Epidermolysis Bullosa Treated with Cyclophosphamide: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-07-14 Cahyani Gita Ambarsari,Retno Palupi-Baroto,Fira Alyssa Gabriella Sinuraya,Elvi Suryati,Etty Widyastuti,Suci Widhiati
Long-term inflammation and recurrent skin infection in recessive dystrophic epidermolysis bullosa (RDEB) are associated with the presence of immunoglobulin A (IgA)-containing immune complexes in the glomerulus. Only eight pediatric RDEB cases with IgA nephropathy (IgAN) have been documented in English-language literature. Most RDEB patients with IgAN progress to kidney failure within 5 years of diagnosis
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Single-Dose Pharmacokinetics and Total Removal of Cyclophosphamide in a Patient with Acute Kidney Injury Undergoing Intermittent Haemodialysis and Prolonged Intermittent Kidney Replacement Therapy: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-07-13 Catherina Lück,Gernot Beutel,W Nikolaus Kühn-Velten,Jan T Kielstein
The largest study on cyclophosphamide pharmacokinetics in dialysis patients comprises of 6 subjects. In the 2 decades since these data were obtained, dialyser membranes, treatment intensities, and treatment duration have changed considerably making new pharmacokinetic studies desirable. We aimed to readdress the pharmacokinetics of cyclophosphamide in a 74-year-old critically ill male suffering from
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A Case Report of Kidney-Only Transplantation in Primary Hyperoxaluria Type 1: A Novel Approach with the Use of Nedosiran. Case Rep. Nephrol. Dial. Pub Date : 2023-07-07 Matthew C Breeggemann,Stephen L Gluck,Marshall L Stoller,Marsha M Lee
The primary hyperoxalurias (PHs) are a group of diseases characterized by kidney stones, nephrocalcinosis, and chronic kidney disease. At stages of advanced kidney disease, glomerular filtration of oxalate becomes insufficient, plasma levels increase, and tissue deposition may occur. Hemodialysis is often unable to overcome the excess hepatic oxalate production. The current surgical management of primary
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A Case of Multicystic Dysplastic Kidney Presenting as a Single Midline Pelvic Cyst. Case Rep. Nephrol. Dial. Pub Date : 2023-07-04 Kristin M Ebert,Christina B Ching
We present an unusual case of a female neonate presenting with a single midline pelvic cyst. Prenatal imaging was suggestive of multicystic dysplastic kidney (MCDK), but postnatal imaging was atypical for this diagnosis given the location and singular cyst noted. The patient ultimately underwent surgical exploration and was diagnosed with an ectopic MCDK. Ectopic MCDK should be considered in the differential
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Low-Density Lipoprotein Adsorption by Centrifugal Plasma Separation Can Shorten Treatment Time. Case Rep. Nephrol. Dial. Pub Date : 2023-07-04 Atsushi Ohkubo,Takatoshi Sakurasawa,Shotaro Naito
Low-density lipoprotein (LDL) apheresis is effective for nephrotic syndrome in drug-resistant focal segmental glomerulosclerosis (FSGS). Dextran sulfate adsorption of LDL (DSAL) is widely used for this purpose. The Liposorber LA-15 system performs DSAL by membrane plasma separation (mDSAL) using an MA-03 plasma purification device. However, sufficient blood flow (Qb) frequently cannot be obtained from
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Recurrent Hyponatremia in the Setting of Autoimmune Disease with Sicca Syndrome: A Case Report. Case Rep. Nephrol. Dial. Pub Date : 2023-06-21 Ahmad El-Moussa,Syed Umer Mohsin,Omer Alrawi,Obead Yaseen,Yahya Osman Malik
Sjogren's syndrome is an autoimmune disease associated with xerostomia and xerophthalmia. The association of Sjogren's with hyponatremia has rarely been reported and has been attributed to syndrome of inappropriate antidiuretic hormone secretion. Here, we report a case of polydipsia secondary to xerostomia as a cause of chronic hyponatremia in the setting of Sjogren's syndrome. Analysis of the patient's
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Acquired Perforating Dermatosis as a Paraneoplastic Feature: A Case Report, Literature Review, and Novel Association. Case Rep. Nephrol. Dial. Pub Date : 2023-06-20 Nashat Imran
Kyrle's disease is an uncommon form of acquired transepidermal elimination dermatosis frequently associated with diabetes mellitus and chronic kidney disease. An association with malignancy has been sporadically reported in the literature. Here, we describe the clinical course of a diabetic patient with end-stage renal disease who developed this disorder as a herald to a regionally advanced renal cell
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Isolated Proteinuria Caused by CUBN Gene Mutations: A Case Report and Review of the Literature. Case Rep. Nephrol. Dial. Pub Date : 2023-05-26 Jingyang Ran,Qingsong Chen,Yudong Hu,Pengfei Yang,Guiquan Yu,Xiaohui Liao,Jianrong Lei
Mutations in the cubilin (CUBN) gene commonly cause Imerslund-Gräsbeck syndrome, while isolated proteinuria as a result of CUBN variations is rarely reported. The clinical manifestation is mainly chronic isolated proteinuria in the non-nephrotic range. However, findings to date suggest that isolated proteinuria associated with abnormalities in the CUBN gene is benign and does not affect long-term prognosis
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Unusual Cause of Thrombocytopenia and Renal Failure in a 14-Year-Old Boy (MYH9-Associated Disorders). Case Rep. Nephrol. Dial. Pub Date : 2023-05-15 Karol Granak,Miroslava Brndiarova,Matej Vnucak,Ivana Plamenova,Regina Behulova Lohajova,Romana Valencikova,Milos Jesenak,Ivana Dedinska
MYH9-associated disorders represent rare group of autosomal dominant diseases and are caused by pathogenic mutations in the MYH9 gene. Clinically, they are represented by macro-platelet-thrombocytopenia, various degrees of renal dysfunction, hearing loss, and early onset cataracts. We describe the case of 14-year-old boy in medical follow-up from birth for thrombocytopenia. Systolic hypertension and
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Success of Pregnancy in a Patient on High-Volume Hemodiafiltration with Citrate-Acidified Dialysate Case Rep. Nephrol. Dial. Pub Date : 2023-03-31 Gaelle Pelle, Arwa Jalal Eddine, Philippe Rieu, Julie Attias, Stephanie Fay, Alexandre Hertig
Although pregnancy in dialysis patients is rare, recent reports in the literature have shown improvement in pregnancy outcome in this population. Increasing doses of dialysis have led to improvement in fetal prognosis, but recommendations are still lacking, and there are few documented reports of pregnant woman on high-volume online hemodiafiltration. Here, we report the first successful pregnancy
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First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report Case Rep. Nephrol. Dial. Pub Date : 2023-01-27 Kyle A. Merrill, Kelli A. Krallman, Daniel Loeb, Stephen W. Standage, Dawn Mattoon, Dandan Shan, Stuart L. Goldstein, Meredith P. Schuh
The Seraph® 100 Microbind® Affinity Blood Filter (Seraph® 100) is a hemoperfusion device designed to adsorb bacteria, viruses, and toxins when added to extracorporeal circuits. The FDA granted emergency use authorization in adults, but this device had never been utilized in children. A 17-year-old patient with asthma presented with respiratory distress due to COVID-19. His course was complicated by
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Severe Neurological Involvement in an Adult with Shiga Toxin-Producing Escherichia coli-Hemolytic Uremic Syndrome Treated with Eculizumab Case Rep. Nephrol. Dial. Pub Date : 2023-01-27 Pauline Vanesse, Hélène Georgery, Thierry Duprez, Ludovic Gerard, Christine Collienne, Alexia Verroken, Florence Crombé, Johann Morelle, Philippe Hantson
A 68-year-old man with a medical history of hypertension was admitted to the emergency department for diffuse abdominal pain preceded by bloody diarrhea. Upon admission, neurological examination was normal, but he suddenly developed a left-sided hemiparesis. After a normal brain computed tomography, intravenous thrombolysis was administered for a suspicion of ischemic stroke. In the first laboratory
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Acknowledgement to Reviewers Case Rep. Nephrol. Dial. Pub Date : 2022-12-16
Case Rep Nephrol Dial 2022;12:262–263
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Catastrophic Fibromuscular Dysplasia Presenting with Concomitant Bilateral Renal Infarction, Vertebral Artery Dissection, and Mesenteric Ischaemia Case Rep. Nephrol. Dial. Pub Date : 2022-11-30 Nicholas Martin Gourd, Hannah Elizabeth Jenkins, Richard Miles, Adrienne Lee, Justin Mason, Andrew Connor
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disorder of the arterial wall muscular layer which can lead to arterial stenosis, occlusion, and dissection. Clinical presentations of FMD vary depending on the arterial territories involved, often leading to diagnostic challenges. This case report describes an exceptionally unusual presentation of FMD, not previously described
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Catastrophic Fibromuscular Dysplasia Presenting with Concomitant Bilateral Renal Infarction, Vertebral Artery Dissection, and Mesenteric Ischaemia Case Rep. Nephrol. Dial. Pub Date : 2022-11-30
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disorder of the arterial wall muscular layer which can lead to arterial stenosis, occlusion, and dissection. Clinical presentations of FMD vary depending on the arterial territories involved, often leading to diagnostic challenges. This case report describes an exceptionally unusual presentation of FMD, not previously described
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Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient Case Rep. Nephrol. Dial. Pub Date : 2022-11-28 Rita Serra Afonso, Roberto Calças Marques, Henrique Borges, Eduarda Carias, Ana Teresa Domingos, Ana Cabrita, Sandra Sampaio, Ana Paula Silva
Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American
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Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient Case Rep. Nephrol. Dial. Pub Date : 2022-11-28
Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American
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Anti-GBM Disease after Oxford-AstraZeneca ChAdOx1 nCoV-19 Vaccination: A Report of Two Cases Case Rep. Nephrol. Dial. Pub Date : 2022-11-22
There have been reports of rare de novo glomerular diseases following vaccination for coronavirus disease 2019 (COVID-19). We report two cases of anti-glomerular basement membrane (GBM) disease in previously healthy females after Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19). The first case was a 69-year-old female who developed lethargy and anuria approximately 8 weeks after her first dose
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Efficacy and Safety of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist in Real-Life: A Case Series of Patients in Maintenance Incremental Hemodialysis Case Rep. Nephrol. Dial. Pub Date : 2022-11-22 José C. De la Flor, Javier Deira Lorenzo, Alexander Marschall, Francisco Valga, Tania Monzón Vázquez, Elisa Ruiz Cícero
The glucagon-like peptide-1 receptor agonists (GLP-1RA) are among the newest treatment options available for managing of type 2 diabetes mellitus and slowing the progression of diabetes kidney disease (DKD). Subcutaneous (SC) semaglutide (Ozempic®) is a GLP-1RA with an extended half-life of approximately 1 week. GLP-1RA are highly effective in improving glycemic control and also show other beneficial
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Anti-GBM Disease after Oxford-AstraZeneca ChAdOx1 nCoV-19 Vaccination: A Report of Two Cases Case Rep. Nephrol. Dial. Pub Date : 2022-11-22
There have been reports of rare de novo glomerular diseases following vaccination for coronavirus disease 2019 (COVID-19). We report two cases of anti-glomerular basement membrane (GBM) disease in previously healthy females after Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19). The first case was a 69-year-old female who developed lethargy and anuria approximately 8 weeks after her first dose
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Efficacy and Safety of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist in Real-Life: A Case Series of Patients in Maintenance Incremental Hemodialysis Case Rep. Nephrol. Dial. Pub Date : 2022-11-22
The glucagon-like peptide-1 receptor agonists (GLP-1RA) are among the newest treatment options available for managing of type 2 diabetes mellitus and slowing the progression of diabetes kidney disease (DKD). Subcutaneous (SC) semaglutide (Ozempic®) is a GLP-1RA with an extended half-life of approximately 1 week. GLP-1RA are highly effective in improving glycemic control and also show other beneficial
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Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome? Case Rep. Nephrol. Dial. Pub Date : 2022-11-11 Hans-Joachim Schurek, Peter Maisel, Udo Helmchen, Björn Reusch, Arnulf Pekrun
A 32-year-old male patient presented the clinical picture of loin pain haematuria syndrome with pain attacks accompanied by macrohaematuria. In renal biopsy, the preglomerular vessels showed segmental wall hyalinosis in the sense of low-grade nephrosclerosis, and glomerular capillaries with slightly but diffusely thickened, non-split basal membranes on electron microscopy. Notable were irregularly
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Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome? Case Rep. Nephrol. Dial. Pub Date : 2022-11-11
A 32-year-old male patient presented the clinical picture of loin pain haematuria syndrome with pain attacks accompanied by macrohaematuria. In renal biopsy, the preglomerular vessels showed segmental wall hyalinosis in the sense of low-grade nephrosclerosis, and glomerular capillaries with slightly but diffusely thickened, non-split basal membranes on electron microscopy. Notable were irregularly
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Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature Case Rep. Nephrol. Dial. Pub Date : 2022-10-27 Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Saleh Kaysi, Joëlle Nortier, Maria do Carmo Filomena Mesquita
Anuric hemodialyzed end-stage renal disease patients are prone to multiple complications and comorbidities and are therefore often treated with various medications. Adverse drug reactions and risk factors leading to them can be difficult to discern in such polymedicated patients. Most problems regarding low phosphate levels are frequently underdiagnosed in clinical practice and sometimes overlooked
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Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis Case Rep. Nephrol. Dial. Pub Date : 2022-10-27 Gilda Portalatin, Shruti Shettigar, Astrid Carrion-Rodriguez, Sushma Medikayala, Leal Herlitz, Dianne Sandy, Surafel K. Gebreselassie, Shane A. Bobart
Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing
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Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature Case Rep. Nephrol. Dial. Pub Date : 2022-10-27
Anuric hemodialyzed end-stage renal disease patients are prone to multiple complications and comorbidities and are therefore often treated with various medications. Adverse drug reactions and risk factors leading to them can be difficult to discern in such polymedicated patients. Most problems regarding low phosphate levels are frequently underdiagnosed in clinical practice and sometimes overlooked
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Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis Case Rep. Nephrol. Dial. Pub Date : 2022-10-27
Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing
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A Friend or a Foe? Bariatric Surgery in Chronic Kidney Disease: A Case Report Case Rep. Nephrol. Dial. Pub Date : 2022-10-24 Sahil Bagai, Bhavna Bansal, Vipra Malik, Pallavi Prasad, Dinesh Khullar
There has been a parallel rise in the need for bariatric surgery as the prevalence of obesity has increased by leaps and bounds over the last 2 decades. Certain procedures like Roux-en-Y gastric bypass are associated with nephrolithiasis, hyperoxaluria, and, rarely, oxalate nephropathy. We report an interesting case of a patient who had relentless progression of his kidney disease post-bariatric surgery
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A Friend or a Foe? Bariatric Surgery in Chronic Kidney Disease: A Case Report Case Rep. Nephrol. Dial. Pub Date : 2022-10-24
There has been a parallel rise in the need for bariatric surgery as the prevalence of obesity has increased by leaps and bounds over the last 2 decades. Certain procedures like Roux-en-Y gastric bypass are associated with nephrolithiasis, hyperoxaluria, and, rarely, oxalate nephropathy. We report an interesting case of a patient who had relentless progression of his kidney disease post-bariatric surgery
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An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report Case Rep. Nephrol. Dial. Pub Date : 2022-10-20 Luiz Henrique Lélis Miranda, Débora Nóbrega de Lima, Marclébio Manuel Coêlho Dourado
Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with
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Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus Case Rep. Nephrol. Dial. Pub Date : 2022-10-20 Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor
Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus. The pathogenesis involved glomerular immune complex deposition, which leads to glomerular inflammation and typically shows a “full-house” pattern on immunofluorescence
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An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report Case Rep. Nephrol. Dial. Pub Date : 2022-10-20
Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with
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Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus Case Rep. Nephrol. Dial. Pub Date : 2022-10-20
Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus. The pathogenesis involved glomerular immune complex deposition, which leads to glomerular inflammation and typically shows a “full-house” pattern on immunofluorescence
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Serum Uromodulin Is a Possible Auxiliary Diagnostic Tool for Acute Tubular Injury and Acute Interstitial Nephritis: A Case Series Case Rep. Nephrol. Dial. Pub Date : 2022-10-11 Ryosuke Usui, Tetsuya Ogawa, Chihiro Iwasaki, Kosaku Nitta, Minako Koike
Recently, the usefulness of serum uromodulin (sUmod) as a novel renal biomarker has been attracting attention. Clinical evidence regarding sUmod measurements has been accumulated by analyzing cross-sectional data. However, little is known about the longitudinal data on sUmod. Therefore, we decided to investigate the variability of sUmod in patients with acute kidney injury due to different causes.
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Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases Case Rep. Nephrol. Dial. Pub Date : 2022-10-04 Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza
Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy to achieve and/or maintain long-term remission. We report successful treatment of pediatric FSGS with rituximab infusions, followed by maintenance
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Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence? Case Rep. Nephrol. Dial. Pub Date : 2022-10-04 Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L’Imperio, Federico Pieruzzi, Renato Alberto Sinico
AA amyloidosis may complicate several chronic inflammatory conditions. From a clinical point of view, causality between inflammatory pathology and AA amyloidosis can be assumed because of the data described in the literature; some of the best known include rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and chronic infections. Singles cases of inflammatory diseases have been
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More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients Case Rep. Nephrol. Dial. Pub Date : 2022-09-26 Kijanosh Lehmann, Sara Diab, Torsten M. Meyer, Jan T. Kielstein, Gabriele Eden
In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted. This is further aggravated by the fact that even for substances with a narrow therapeutic range, drug monitoring is only rarely offered, let alone advocated. This holds also true for gabapentin, an anticonvulsant
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Actinotignum schaalii Can Be an Uropathogen of “Culture-Negative” Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities Case Rep. Nephrol. Dial. Pub Date : 2022-09-26 Mami Washio, Nobutaka Harada, Daisuke Nishima, Megumi Takemoto
Accurate diagnosis and treatment of febrile urinary tract infections (UTI) during childhood are important for the prevention of renal parenchymal damage and functional loss, and detection of underlying diseases related to chronic kidney disease (CKD). Actinotignum schaalii (A. schaalii)-related febrile UTI in children is rare, and its incidence and risk factors remain unclear. A 3-year-old boy with
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Butyricimonas virosa Peritonitis in Peritoneal Dialysis Patient: A Case Report and Review Case Rep. Nephrol. Dial. Pub Date : 2022-09-26 Siew Yan Lau, Boon Cheak Bee, Hin-Seng Wong, Ahneez Abdul Hameed
Butyricimonas virosa is a Gram-negative bacillus, which was first discovered in rat faeces in 2009. To date, only seven human infections have been reported in literature. To our knowledge, this is the first reported case of peritoneal dialysis (PD)-related peritonitis due to B. virosa. A 65-year-old Chinese man presented to the hospital with complaints of dizziness and vomiting. On admission, the drained
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Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication Case Rep. Nephrol. Dial. Pub Date : 2022-09-26 Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar
Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam
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Vena Cava Superior Syndrome Six Years after Central Venous Catheter Removal in a Patient on Hemodialysis Case Rep. Nephrol. Dial. Pub Date : 2022-08-29 Michelle Janssen, Susan Logtenberg
Vena cava superior (VCS) syndrome is rarely seen as a complication of central-venous-catheter placement. Usually, the syndrome appears when the presence of the catheter causes intraluminal obstruction or thrombosis. In this case report, however, we describe a patient on intermittent hemodialysis who had been free of any venous central line for over 6 years, presented with a VCS syndrome. The CT scan
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Severe Bullous Pemphigoid Onset after Jugular Catheter Placement in a Patient on Hemodialysis Case Rep. Nephrol. Dial. Pub Date : 2022-08-29 Lucas Jacobs, Francesco Feoli, Pascal Bruderer, Semra Top, Ivan Grozdev, Edouard Cubilier, Frederic Collart
Pruritus is highly prevalent in the dialysis population. Its etiology however remains often unclear with uremic pruritus primarily suspected unless compelling evidence of another cause. Although bullous pemphigoid (BP) is considered idiopathic, there are growing data in the literature on BP provoked by different factors, such as medications or surgical procedures. These secondary dermatoses are described
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Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature Case Rep. Nephrol. Dial. Pub Date : 2022-08-19 Maha Mohamed, Muhammad Waseem Athar, Yaasir Mamoojee, Alison Brown, Frances Dowen, Jim Macfarlane
Tuberculosis (TB) infection of the genitourinary tract (GU TB) is rare in renal transplant recipients, with only a few published case series. GU TB is difficult to diagnose with or without immunosuppression but must always be suspected in any patient with unexplained sterile pyuria. As GU TB is associated with graft rejection, prompt diagnosis and treatment are vital. Treatment is challenging, as rifampicin
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Four Cases of Serum Copper Excess in Patients with Renal Anemia Receiving a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor: A Possible Safety Concern Case Rep. Nephrol. Dial. Pub Date : 2022-08-19 Hironori Nakamura, Shigekazu Kurihara, Mariko Anayama, Yasushi Makino, Masaki Nagasawa
Copper is an indispensable trace metal element and is mainly absorbed in the stomach and small intestine and excreted into the bile. Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel approach for renal anemia management. Many intestinal genes, including divalent metal transporter 1, duodenal cytochrome B, and copper transporter ATPase7A, related to iron absorption
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Acute Kidney Injury following Exposure to Formaldehyde-Free Hair-Straightening Products Case Rep. Nephrol. Dial. Pub Date : 2022-07-11 Nabil Abu-Amer, Natalie Silberstein, Margarita Kunin, Sharon Mini, Pazit Beckerman
Formaldehyde-free hair-straightening products are hair-smoothening solutions widely used by professional beauty salons. Formaldehyde-free hair straighteners do not technically contain formaldehyde; however, they contain other chemicals such as glyoxyloyl carbocysteine which releases formaldehyde upon contact with heat. Moreover, its by-product glyoxylate may convert to oxalate; both compounds have
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Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis with Renal and Lung Involvement Case Rep. Nephrol. Dial. Pub Date : 2022-06-17 Albert Hing Wong, Wei-Kei Wong, Lai-Meng Looi, Jeyakantha Ratnasingam, Soo-Kun Lim
Propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a rare and heterogeneous disease. Moreover, optimal treatment is still lacking. We described the case of a 44-year-old lady with underlying Graves’ disease who had cough, blood-streaked sputum, and impaired renal function. A strongly positive anti-myeloperoxidase antibody (#x3e;200 U/mL) along