-
Clinicopathological characteristics and predictors of outcome of rapidly progressive glomerulonephritis: a retrospective study BMC Nephrol. (IF 2.3) Pub Date : 2024-03-18 Osama Nady Mohamed, Sharehan Abdelrahman Ibrahim, Rabeh Khairy Saleh, Ahmed S. Issa, Amr Setouhi, Ayman Ahmed Abd Rabou, Mahmoud Ragab Mohamed, Shaimaa F. Kamel
Globally, there are regional and time-based variations in the prevalence, etiology, and prognosis of rapidly progressive glomerulonephritis (RPGN). Prognosis of RPGN is poor, with a higher risk of death and end stage renal disease (ESRD) even with immunosuppressive medications. In the Middle East and North Africa, the studies on this disease are very limited. Therefore, we determined the predictors
-
Management of kidney transplant recipients for primary care practitioners BMC Nephrol. (IF 2.3) Pub Date : 2024-03-18 Manal Alotaibi, Brandon Trollinger, Sam Kant
Patients with kidney transplants have a significant co-morbidity index, due to a high number of pre-existing conditions and use of immunosuppression medications. These patients are at higher risk of developing conditions such as hypertension, dyslipidemia, post-transplant diabetes, cardiovascular events, and anemia. Moreover, they are particularly susceptible to infections such as urinary tract infections
-
Development and validation of a machine learning model to predict time to renal replacement therapy in patients with chronic kidney disease BMC Nephrol. (IF 2.3) Pub Date : 2024-03-16 Jun Okita, Takeshi Nakata, Hiroki Uchida, Akiko Kudo, Akihiro Fukuda, Tamio Ueno, Masato Tanigawa, Noboru Sato, Hirotaka Shibata
Predicting time to renal replacement therapy (RRT) is important in patients at high risk for end-stage kidney disease. We developed and validated machine learning models for predicting the time to RRT and compared its accuracy with conventional prediction methods that uses the rate of estimated glomerular filtration rate (eGFR) decline. Data of adult chronic kidney disease (CKD) patients who underwent
-
The moderating role of social support in the relationship between death anxiety and resilience among dialysis patients BMC Nephrol. (IF 2.3) Pub Date : 2024-03-16 Zahra Shafiei Kisomi, Omid Taherkhani, Mina Mollaei, Hoda Esmaeily, Ghazaleh Shirkhanloo, Zahra Hosseinkhani, Mohammad Amerzadeh
Chronic Kidney Disease (CKD) who receive social support can cope with the challenges. Therefore, this study determined the moderating role of social support in the relationship between death anxiety and resilience among dialysis patients in Qazvin City. This cross-sectional study used a descriptive-analytical approach on 347 dialysis patients in Qazvin City. The data collection tools included several
-
Rate and reasons for peritoneal dialysis dropout following haemodialysis to peritoneal dialysis switch: a systematic review and meta-analysis BMC Nephrol. (IF 2.3) Pub Date : 2024-03-16 Xingge Sun, Clare McKeaveney, Joanne Shields, Chi Peng Chan, Matthew Henderson, Fiona Fitzell, Helen Noble, Stephen O’Neill
Patient experiences and survival outcomes can be influenced by the circumstances related to dialysis initiation and subsequent modality choices. This systematic review and meta-analysis aimed to explore the rate and reasons for peritoneal dialysis (PD) dropout following haemodialysis (HD) to PD switch. This systematic review conducted searches in four databases, including Medline, PubMed, Embase, and
-
Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020 BMC Nephrol. (IF 2.3) Pub Date : 2024-03-16 Ursula Kirchmayer, Claudia Marino, Sandro Feriozzi, Carlo Massimetti, Micol Manzuoli, Laura Angelici, Anna Maria Bargagli, Silvia Cascini, Antonio Addis, Marina Davoli, Nera Agabiti
Entering dialysis is a critical moment in patients’ healthcare journey, and little is known about drug therapy around it. A study funded by the Italian Medicines Agency offered the opportunity to leverage data from the Lazio Regional Dialysis and Transplant Registry (RRDTL) and perform an observational study on drug use patterns before and after initiating chronic dialysis. Individuals initiating dialysis
-
Dotinurad restores exacerbated kidney dysfunction in hyperuricemic patients with chronic kidney disease BMC Nephrol. (IF 2.3) Pub Date : 2024-03-15 Hoichi Amano, Seiji Kobayashi, Hiroyuki Terawaki
In this study, we aimed to clarify the beneficial effects of urate-lowering treatment with the novel agent dotinurad on renal function in patients with chronic kidney disease (CKD) and hyperuricemia (HUA). Thirty-five patients with CKD (mean age 65.4 ± 14.8 years, 23 men) diagnosed with HUA were recruited. Changes in eGFR before and after dotinurad administration were assessed. Patients first underwent
-
Kidney replacement and conservative therapies in rhabdomyolysis: a retrospective analysis BMC Nephrol. (IF 2.3) Pub Date : 2024-03-14 Jonathan de Fallois, Robert Scharm, Tom H. Lindner, Christina Scharf, Sirak Petros, Lorenz Weidhase
Toxic renal effects of myoglobin following rhabdomyolysis can cause acute kidney injury (AKI) with the necessity of kidney replacement therapy (KRT). Fast elimination of myoglobin seems notable to save kidney function and intensify kidney repair. Clinical data regarding efficacy of KRT in critical care patients with rhabdomyolysis and AKI are limited. This retrospective analysis aimed to identify differences
-
Deep learning algorithms for predicting renal replacement therapy initiation in CKD patients: a retrospective cohort study BMC Nephrol. (IF 2.3) Pub Date : 2024-03-14 Ka-Chun Leung, Wincy Wing-Sze Ng, Yui-Pong Siu, Anthony Kai-Ching Hau, Hoi-Kan Lee
Chronic kidney disease (CKD) requires accurate prediction of renal replacement therapy (RRT) initiation risk. This study developed deep learning algorithms (DLAs) to predict RRT risk in CKD patients by incorporating medical history and prescriptions in addition to biochemical investigations. A multi-centre retrospective cohort study was conducted in three major hospitals in Hong Kong. CKD patients
-
Evaluating inter-rater reliability in the context of “Sysmex UN2000 detection of protein/creatinine ratio and of renal tubular epithelial cells can be used for screening lupus nephritis”: a statistical examination BMC Nephrol. (IF 2.3) Pub Date : 2024-03-13 Ming Li, Qian Gao, Jing Yang, Tianfei Yu
The evaluation of inter-rater reliability (IRR) is integral to research designs involving the assessment of observational ratings by two raters. However, existing literature is often heterogeneous in reporting statistical procedures and the evaluation of IRR, although such information can impact subsequent hypothesis testing analyses. This paper evaluates a recent publication by Chen et al., featured
-
Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population BMC Nephrol. (IF 2.3) Pub Date : 2024-03-13 Tomas Månsson, Aldana Rosso, Katarina Ellström, Kasim Abul-Kasim, Sölve Elmståhl
Cerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel disease, and
-
Systemic inflammation and acute kidney injury after colorectal surgery BMC Nephrol. (IF 2.3) Pub Date : 2024-03-11 John D. Mannion, Assar Rather, Adrianne Fisher, Kelly Gardner, Nessreen Ghanem, Sheila Dirocco, Gary Siegelman
In this retrospective review, the relative importance of systemic inflammation among other causes of acute kidney injury (AKI) was investigated in 1224 consecutive colorectal surgery patients. A potential benefit from reducing excessive postoperative inflammation on AKI might then be estimated. AKI was determined using the Kidney Disease Improving Global Outcomes (KDIGO) criteria. The entire population
-
Decreasing incidence of hospital diagnosed CKD/CKDu in North Central Province of Sri Lanka: is it related to provision of drinking water reverse osmosis plants? BMC Nephrol. (IF 2.3) Pub Date : 2024-03-11 Asanga Venura Ranasinghe, Lakshmi C. Somatunga, Gardiye Weligamage Gamini Priyantha Kumara, Ranamuka Henayage Karunarathna, Ambepitiyawaduge Pubudu De Silva, Jayaprakara Mudiyanselage Chathurika Nayani Gunawardena, Sembu Kuttige Champika Ruwan Kumari, Mohamed Shali Fathima Sarjana, Mannikawadumesthri Vipula Chandu De Silva
We assessed the possible impact of provision of reverse osmosis (RO) water on the incidence of hospital diagnosed CKD/CKDu in North Central Province (NCP) of Sri Lanka. An ecological study was conducted on data from 2010–2020 on the incidence of hospital diagnosed CKD/CKDu, CKD/CKDu screening and provision of drinking water RO plants in NCP. Analysis was conducted using descriptive statistics, ANOVA
-
Is central venous catheter in haemodialysis still the main factor of mortality after hospitalization? BMC Nephrol. (IF 2.3) Pub Date : 2024-03-08 Erwin Campos, Miguel Angel Cuevas-Budhart, Renata Cedillo-Flores, Julián Candelario-López, Rigoberto Jiménez, Alberto Flores-Almonte, Alfonso Ramos-Sanchez, Jose C. Divino Filho
Haemodialysis is the most frequently prescribed Renal Replacement Therapy modality worldwide. However, patients undergoing this therapy have an unpredictable evolution related to vascular access. To determine the factors associated with the mortality and hospitalization rate in haemodialysis patients at a third-level care Centre in the Dominican Republic. This was an observational and prospective study
-
Relationship between serum phosphorus and mortality in non-dialysis chronic kidney disease patients: evidence from NHANES 2001–2018 BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Zhongcheng Fan, Rugang Li, Miaoxia Pan, Yangyang Jiang, Ying Li, Li Liu, Yang Li
Hyperphosphatemia is common in chronic kidney disease (CKD), associated with higher mortality in dialysis patients. Its impact in non-dialysis patients, especially those with preserved kidney function, remains uncertain. A prospective cohort study was conducted using data from the National Health and Nutrition Examination Survey (2001–2008). Serum phosphorus was analyzed as a continuous variable, or
-
Polycystic intrahepatic infection caused by Enterococcus casseliflavus: a case report and literature review BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Senyin Xu, Bin Huang, Youjun Cao, Zhongyong Zhong, Jiazhen Yin
Enterococcus casseliflavus is a rare pathogenic bacterium that is characterized by vancomycin resistance and can lead to multiple infections in the human body. This report describes a rare case of polycystic intrahepatic infection with E. casseliflavus which necessitated antibiotic treatment and surgical intervention involving cystic drainage. A 59-year-old woman, a long-term hemodialysis patient,
-
A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Yuhao Liu, Yaqi Cheng, Yubing Wen, Chao Li, Gang Chen, Mingxi Li
This article reports an extremely rare case of lipoprotein glomerulopathy (LPG) with apolipoprotein E gene (APOE) Chicago mutation in a young Chinese male. Only five cases or families with APOE Chicago mutations have been reported in the literature. The young male patient is manifested with nephrotic syndrome, accompanied by hyperlipidemia with a preferable increase in triglycerides and elevated ApoE
-
Rituximab may affect T lymphocyte subsets balance in primary membranous nephropathy BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Yuanyuan Zhang, Jingjing Yang, Jianzhong Li, Jiani Sun, Ling Zhou, Deyu Xu, Wengang Sha, Lan Dai, Lei Shen
The aim of this study was to investigate the effects and significance of rituximab (RTX) on the levels of T lymphocyte subsets in patients diagnosed with primary membranous nephropathy (PMN). A total of 58 PMN patients and 25 healthy donors were chosen as the subjects. Among the PMN patients, 40 individuals received RTX treatment and completed at least 6 months of follow-up. All subjects underwent
-
Peritoneal dialysis vs. hemodialysis among patients with end-stage renal disease in Iran: which is more cost-effective? BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Mahmood Yousefi, Satar Rezaei, Sakineh Hajebrahimi, Niloofar Falsafi, Fatemeh Keshvari-Shad
There is little economic evidence on different modalities among patients with end-stage renal disease (ESRD) in Iran. This study aimed to assess the cost-utility of peritoneal dialysis (PD) and hemodialysis (HD) among ESRD patients in Iran. From the health system perspective and with a 10-year time horizon, we conducted a cost-utility analysis based on a Markov model to compare three strategies of
-
Consensus recommendations on fasting during Ramadan for patients with kidney disease: review of available evidence and a call for action (RaK Initiative) BMC Nephrol. (IF 2.3) Pub Date : 2024-03-06 Yousef Boobes, Bachar Afandi, Fatima AlKindi, Ahmad Tarakji, Saeed M. Al Ghamdi, Mona Alrukhaimi, Mohamed Hassanein, Ali AlSahow, Riyad Said, Jafar Alsaid, Abdulkareem O. Alsuwaida, Ali A. K. Al Obaidli, Latifa B. Alketbi, Khaled Boubes, Nizar Attallah, Issa S. Al Salmi, Yasser M. Abdelhamid, Nihal M. Bashir, Rania M. Y. Aburahma, Mohamed H. Hassan, Mohammad R. Al-Hakim
Ramadan fasting (RF) involves abstaining from food and drink during daylight hours; it is obligatory for all healthy Muslims from the age of puberty. Although sick individuals are exempt from fasting, many will fast anyway. This article explores the impact of RF on individuals with kidney diseases through a comprehensive review of existing literature and consensus recommendations. This study was conducted
-
The mediating effect of family resilience between coping styles and caregiver burden in maintenance hemodialysis patients: a cross-sectional study BMC Nephrol. (IF 2.3) Pub Date : 2024-03-05 Qianjun Zhang, Qiaoling Liu, Li Zhang, Yabin Jin, Xia Xiang, Xuefang Huang, Jiezhen Mai, Tingfen Zhao, Wen Cui
Primary caregivers of hemodialysis patients suffer from varying degrees of stress from their patients. Caring for hemodialysis patients can expose caregivers to many problems, leading to an increased burden of care and even impacting the quality of care. The purpose of our study was to examine whether family resilience could be a mediating variable moderating the relationship between patient coping
-
Uric acid in predicting the traumatic rhabdomyolysis induced acute kidney injury; a systematic review and meta-analysis BMC Nephrol. (IF 2.3) Pub Date : 2024-03-05 Saeed Safari, Mohammadreza Ghasemi, Mahmoud Yousefifard, Alireza Ghasemi, Iraj Najafi
The objective of this systematic review and meta-analysis was to assess the value of uric acid in predicting acute kidney injury caused by traumatic rhabdomyolysis. The search was conducted in MEDLINE, Scopus, Embase and Web of Science until November 1, 2023. Based on the inclusion and exclusion criteria, the articles were included by two independent researchers. Data regarding study design, patient
-
The association between new inflammation markers and frequent peritoneal dialysis-associated peritonitis BMC Nephrol. (IF 2.3) Pub Date : 2024-03-05 Jing Tang, Dongxue Wang, Yun Chen, Jinhong Feng
To validate an association between new inflammation and frequent peritoneal dialysis-associated peritonitis (PDAP). In China, retrospective clinical data were collected on 208 patients who received continuous ambulatory peritoneal dialysis (CAPD) between 2010 and 2021. The patients were divided into two groups: non-frequent PDAP (the interval between two peritonitis episodes of more than one year)
-
Single-pool model urea clearance index is associated with sarcopenia and nutritional status in patients undergoing maintenance hemodialysis: a cross-sectional study BMC Nephrol. (IF 2.3) Pub Date : 2024-03-05 Yan Li, Tingting Xing, Rong Xu, Yan Liu, Xiaoshi Zhong, Yun Liu, Rongshao Tan
The single-pool model urea clearance index (single-pool Kt/Vurea; spKt/V) is the most commonly used method for dialysis adequacy assessment. However, only a few studies have examined the relationship between spKt/V values and parameters related to sarcopenia and nutritional status. This study aimed to evaluate whether the spKt/V is an indicator of sarcopenia and nutritional status in patients undergoing
-
Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22-3p/TRPM7 axis in septic acute kidney BMC Nephrol. (IF 2.3) Pub Date : 2024-03-05 Pan Zhang, Enwei Guo, Limin Xu, Zhenhua Shen, Na Jiang, Xinhui Liu
Sepsis is a life-threatening, systemic inflammatory disease that can lead to a variety of conditions, including septic acute kidney injury (AKI). Recently, multiple circular Rnas (circRNAs) have been implicated in the development of this disease. In this study, we aimed to elucidate the role of circ-Gatad1 in sepsis induced AKI and its potential mechanism of action. High-throughput sequencing was used
-
Validation of IgA nephropathy diagnosis in the Swedish Renal Registry BMC Nephrol. (IF 2.3) Pub Date : 2024-03-04 Johanna Rehnberg, Mårten Segelmark, Jonas F. Ludvigsson, Louise Emilsson
The Swedish Renal Registry (SRR) is a unique national quality registry that monitors the clinical trajectory of patients with chronic kidney disease (CKD). We have validated the biopsy data registered in the SRR for IgA Nephropathy (IgAN) diagnosis. In total 25% of all patients (n = 142), registered with IgAN in the SRR after having performed a kidney biopsy during 2015–2019, were randomly selected
-
Association of the combination of obstructive sleep apnea risk and sleep duration with ideal cardiovascular health metrics in patients undergoing hemodialysis BMC Nephrol. (IF 2.3) Pub Date : 2024-03-01 Hui Zhang, Ziwei Zhang, Yinjiao Zhao, Peiyu Song, Xiaoyu Chen, Peipei Han, Wei Ding, Liming Zhang, Chen Yu, Huizhi Ma, Qi Guo
The purpose of this study was to explore the separate and combined associations of obstructive sleep apnea (OSA) risk and sleep duration with ideal cardiovascular health metrics in hemodialysis (HD) patients. 470 HD participants (average: 59.48 ± 12.89 y, 281 men) were included in this study. Sleep duration was measured as self-reported average sleep time during the previous month. The OSA risk was
-
Trend analysis and prediction of the incidence and mortality of CKD in China and the US BMC Nephrol. (IF 2.3) Pub Date : 2024-03-01 Wenpeng Zhu, Mengqi Han, Yuxin Wang, Guoping Wang
Currently, limited research is available on the comparative analysis of chronic kidney disease (CKD) incidence and mortality rates between China and the United States. This study aimed to explore the trends in CKD incidence and mortality rates in both countries, as well as make some future predictions. The data on CKD incidence and mortality in China and the US from 1990 to 2019 were derived from the
-
The Intersectoral Coordination Unit for the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) cohort study BMC Nephrol. (IF 2.3) Pub Date : 2024-03-01 Hauke S. Wülfrath, Thorben Schrumpf, Friedrich A. von Samson-Himmelstjerna, Jakob Voran, Yao Zhang, Grit Esser, Sarah-Yasmin Thomsen, Maja L. Messtorff, Theresa Riebeling, Nassim Kakavand, Roland Schmitt, Kevin Schulte, Benedikt Kolbrink
Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate the presumed benefits of PD, including enhanced quality of life and reduced healthcare personnel requirements, and to generate data to strengthen the use of PD. The prospective
-
Long-term ozone exposure and mortality in patients with chronic kidney disease: a large cohort study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-28 Ejin Kim, Hyuk Huh, Yongwon Mo, Jae Yoon Park, Jiyun Jung, Hajeong Lee, Sejoong Kim, Dong Ki Kim, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee, Yong Chul Kim, Ho Kim
Epidemiologic studies on the effects of long-term exposure to ozone (O3) have shown inconclusive results. It is unclear whether to O3 has an effect on chronic kidney disease (CKD). We investigated the effects of O3 on mortality and renal outcome in CKD. We included 61,073 participants and applied Cox proportional hazards models to examine the effects of ozone on the risk of end-stage renal disease
-
Antibiotic dosing recommendations in critically ill patients receiving new innovative kidney replacement therapy BMC Nephrol. (IF 2.3) Pub Date : 2024-02-27 Susan J. Lewis, Bruce A. Mueller
The Tablo Hemodialysis System is a new innovative kidney replacement therapy (KRT) providing a range of options for critically ill patients with acute kidney injury. The use of various effluent rate and treatment durations/frequencies may clear antibiotics differently than traditional KRT. This Monte Carlo Simulation (MCS) study was to develop antibiotic doses likely to attain therapeutic targets for
-
ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis BMC Nephrol. (IF 2.3) Pub Date : 2024-02-27 Yu De Lou, Peng Hui Li, Xiao Qi Liu, Tian Xiang Wang, Yi Lan Liu, Chen Chen Chen, Kun Ling Ma
Diabetic nephropathy (DN) and atherosclerosis (AS) are prevalent and severe complications associated with diabetes, exhibiting lesions in the basement membrane, an essential component found within the glomerulus, tubules, and arteries. These lesions contribute significantly to the progression of both diseases, however, the precise underlying mechanisms, as well as any potential shared pathogenic processes
-
Risk factors for short-term all-cause mortality in patients with end stage renal disease: a scoping review BMC Nephrol. (IF 2.3) Pub Date : 2024-02-27 Wanfen Yip, Sheryl Hui Xian Ng, Palvinder Kaur, Pradeep Paul George, Jennifer Huey Chen Guan, Guozhang Lee, Timothy Jee Kam Koh, Woan Shin Tan, Allyn Yin Mei Hum
There is a lack of prognostic information to guide the prediction of short-term all-cause mortality in patients with end-stage renal disease (ESRD). The aim was to review the risk factors that influenced the risk of short-term all-cause mortality in patients with ESRD. MEDLINE, Embase, PubMed, CINAHL, the Cochrane Library and Web of Science databases were searched for articles published between 2000
-
Gender disparities in kidney replacement therapies and transplantation in Colombia BMC Nephrol. (IF 2.3) Pub Date : 2024-02-26 Laura Nino-Torres, Jessica Pinto-Ramirez, Fernando Giron-Luque, Alejandro Nino-Murcia
In chronic kidney disease (CKD), there are historical inequities in multiple stages of the pathway for organ transplantation. Women have been recognized as disadvantaged within this process even after several efforts. Therefore, we aimed to analyze the prevalence and incidence of CKD by gender and their access to Kidney replacement therapy (KRT) in Colombia. A cross-sectional study based on secondary
-
Dose of nafamostat mesylate during continuous kidney replacement therapy in critically ill patients: a two-centre observational study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-26 Shinya Kameda, Akinori Maeda, Shun Maeda, Yutaro Inoue, Kazunari Takahashi, Akira Kageyama, Kent Doi, Tomoko Fujii
Nafamostat mesylate is an anticoagulant used for critically ill patients during continuous kidney replacement therapy (CKRT), characterised by its short half-life. However, its optimal dosage remains unclear. This study aimed to explore the optimal dosage of nafamostat mesylate during CKRT. We conducted a two-centre observational study. We screened all critically ill adult patients who required CKRT
-
Urokinase prophylactic anticoagulation in children with nephrotic syndrome: a multicenter retrospective cohort study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-26 Zhen Wang, Nan Wang, Ruyue Chen, Hanyun Tang, Qiang Lin, Xiaozhong Li
To analyze the clinical effect of urokinase on the prevention of thrombosis in children with primary nephrotic syndrome. A total of 370 children diagnosed with primary nephrotic syndrome (PNS) in the Children’s Hospital of Soochow University and Zibo Maternal and Child Health Hospital from January 2018 to December 2022 were selected as the research objects. The patients were divided into a urokinase
-
Prevalence of chronic kidney disease in Tunisian diabetics: the TUN-CKDD survey BMC Nephrol. (IF 2.3) Pub Date : 2024-02-25 Jannet Labidi, Amel Harzallah, Badereddine Ben Kaab, Ikram Mami, Sahar Agrebi, Awatef Azzabi, Soumaya Chargui, Mayssa Hadj-Brahim, Mouna Hammouda, Saifeddine Azaiez, Syrine Tlili, Olfa Lajili, Hela Antit, Yosra Hasni, Sarra Chenik, Farhat Chelbi, Lamia Rais, Habib Skhiri
In Tunisia, the prevalence of diabetes mellitus increased from 15.5% on 2016 to 23% by 2023. While Chronic Kidney Disease (CKD) stills the most dreaded complications of diabetes, studies on the prevalence of chronic kidney disease non-dialysis diet are scarce. The aim of this study was to assess the prevalence of chronic kidney disease among the Tunisian diabetic population based on investigators’
-
PLA2R-positive membranous nephropathy in IgG4-related disease BMC Nephrol. (IF 2.3) Pub Date : 2024-02-23 Yusuke Ushio, Taro Akihisa, Kazunori Karasawa, Momoko Seki, Shizuka Kobayashi, Yoei Miyabe, Hiroshi Kataoka, Naoko Ito, Sekiko Taneda, Shin’ichi Akiyama, Akira Hebisawa, Mitsuhiro Kawano, Kazuho Honda, Junichi Hoshino
IgG4-related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple organs, including the pancreas, lacrimal glands, salivary glands, periaortic/retroperitoneum, and kidney. Interstitial nephritis is a typical renal disorder associated with IgG4-RD, but membranous nephropathy is also seen in some cases. Herein we report on the case of a 77-year-old male patient with nephrotic syndrome
-
Prognostic value of transthoracic echocardiography score for the prognosis of continuous ambulatory peritoneal dialysis patients BMC Nephrol. (IF 2.3) Pub Date : 2024-02-23 Sheng Wan, Yanglin Hu, Li Cheng, Da He, Zengsi Wang, Yanmin Zhang
We devoted ourselves to proving that the initial transthoracic echocardiography score (TTES) had predictive significance for patients with continuous ambulatory peritoneal dialysis (CAPD). In this retrospective analysis, 274 CAPD patients who had PD therapy were recruited sequentially. TTE exams were performed three months following the start of PD therapy. All patients were divided into two groups
-
Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker BMC Nephrol. (IF 2.3) Pub Date : 2024-02-23 Beibei Liu, Yanling Hu, Danyang Tian, Jianlong Dong, Bing-Feng Li
Oxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD), prompting the exploration of antioxidants as a potential therapeutic avenue for mitigating disease progression. This study aims to investigate the beneficial impact of Tempol on the progression of CKD in a rat model utilizing oxidized albumin as a biomarker. After four weeks of treatment, metabolic parameters
-
Effects of uric acid-lowering therapy (ULT) on renal outcomes in CKD patients with asymptomatic hyperuricemia: a systematic review and meta-analysis BMC Nephrol. (IF 2.3) Pub Date : 2024-02-23 Yuxin Luo, Qirong Song, Jiaxiao Li, Sha Fu, Wenjuan Yu, Xiaofei Shao, Jinxiang Li, Yuliang Huang, Junzhe Chen, Ying Tang
It is well known that asymptomatic hyperuricemia and gout play an important role in patients with chronic kidney disease (CKD). However, the effect of uric acid-lowering therapy (ULT) on the prognosis of CKD patients with asymptomatic hyperuricemia remains controversial. Therefore, we aim to investigate the influence of ULT on renal outcomes in these patients. Comprehensive searches were conducted
-
Effect of PERLA®, a new cold-storage solution, on oxidative stress injury and early graft function in rat kidney transplantation model BMC Nephrol. (IF 2.3) Pub Date : 2024-02-22 Mohamed Bejaoui, Chérifa Slim, Carmen Peralta, Hassen Ben Abdennebi
The composition of organ preservation solutions is crucial for maintaining graft integrity and early graft function after transplantation. The aim of this study is to compare new organ preservation solution PERLA® with the gold standard preservation solution University of Wisconsin (UW) regarding oxidative stress and early graft injury. In order to assess oxidative stress after cold storage, kidney
-
Case report: enzyme replacement therapy for Fabry disease presenting with proteinuria and ventricular septal thickening BMC Nephrol. (IF 2.3) Pub Date : 2024-02-21 Zewei Chen, Bo Yin, Juan Jiao, Tianyang Ye
Fabry disease (FD) is an uncommon, X-linked, lysosomal storage disease that causes defects in the glycosphingolipid metabolic pathway due to deficient or absent lysosomal α-galactosidase (α-Gal A) activity. This leads to the accumulation of globotriaosylceramide (GL-3) within lysosomes in a wide range of cells, including endothelial, cardiac, renal, and corneal cells, and consequently, the progressive
-
Identifying individuals at risk of needing CKD associated medications in a European kidney disease cohort BMC Nephrol. (IF 2.3) Pub Date : 2024-02-20 Eleni Stamellou, Turgay Saritas, Marc Froissart, Florian Kronenberg, Peter Stenvinkel, David C. Wheeler, Kai-Uwe Eckardt, Jürgen Floege, James Fotheringham
The consequences of chronic kidney disease (CKD) can be addressed with a range of pharmacotherapies primarily prescribed by nephrologists. More accurate information regarding future CKD-related pharmacotherapy requirements could guide clinical decisions including follow-up frequency. Following assignment to derivation and validation groups (2,1), variables predicting individually future use of vitamin
-
Establishing the Kidney dIsease in the National guarD (KIND) registry: an opportunity for epidemiological and clinical research in Saudi Arabia BMC Nephrol. (IF 2.3) Pub Date : 2024-02-19 Mohammed Tawhari, Moustafa Alhamadh, Abdulrahman Alhabeeb, Abdulaziz Ureeg, Suliman Alghnam, Fayez Alhejaili, Lubna A. Alnasser, Abdullah Sayyari
In Saudi Arabia (SA), there has been an alarming increase in the prevalence of chronic kidney diseases (CKD) over the last three decades. Despite being one of the largest countries in the Middle East, renal conditions remain understudied, and there is limited data on their epidemiology and outcomes in SA. To document the experience of establishing a local renal registry assessing the epidemiology of
-
Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis BMC Nephrol. (IF 2.3) Pub Date : 2024-02-17 Yanbin Lin, Jinxuan He, Zhixiang Mou, Huiting Chen, Wenkang You, Tianjun Guan, Lan Chen
Recent studies have suggested that ferroptosis participates in various renal diseases. However, its effect on focal segmental glomerulosclerosis remains unclear. This study analyzed the GSE125779 and GSE121211 datasets to identify the differentially expressed genes (DEGs) in renal tubular samples with and without FSGS. The Cytoscape was used to construct the protein–protein interaction network. Moreover
-
Optimising diagnosis and management of kidney disease: an implementation trial of a clinical decision support system future health today BMC Nephrol. (IF 2.3) Pub Date : 2024-02-16 Hannah Wallace, Qiumian Wang, Tanita Botha, Barbara Hunter, Natalie Lumsden, Craig Nelson
Chronic kidney disease affects more than 10% of the world’s population and is a non-communicable disease of global concern and priority. There is a significant implementation gap between best practice guideline recommendations and current kidney disease management. Previous research has shown the need to partner with primary care to improve education, collaboration, and kidney disease awareness. This
-
Mortality risk in patients with autosomal dominant polycystic kidney disease BMC Nephrol. (IF 2.3) Pub Date : 2024-02-16 Deirdre Mladsi, Xiaolei Zhou, Gregory Mader, Myrlene Sanon, Jinyi Wang, Christine Barnett, Cynthia Willey, Stephen Seliger
Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD). Mortality data specific to patients with ADPKD is currently lacking; thus, the aim of this study was to estimate mortality in patients with ADPKD. We analyzed data from the United States Renal Data System (USRDS) for patients with ADPKD available during the study period of 01/01/2014–12/31/2016
-
The ICD-9 to ICD-10 transition has not improved identification of rapidly progressing stage 3 and stage 4 chronic kidney disease patients: a diagnostic test study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-14 Kabir Jalal, Andre Charest, Xiaoyan Wu, Richard J. Quigg, Shirley Chang
The International Classification of Diseases (ICD) coding system is the industry standard tool for billing, disease classification, and epidemiology purposes. Prior research has demonstrated ICD codes to have poor accuracy, particularly in relation to rapidly progressing chronic kidney disease (CKD) patients. In 2016, the ICD system moved to revision 10. This study examines subjects in a large insurer
-
The differential effect of modern intravenous iron on fibroblast growth factor 23 and phosphate in non-dialysis dependent CKD – the exploratory randomized controlled double-blind ExplorIRON-CKD study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-12 Xenophon Kassianides, Sunil Bhandari
Intravenous iron is commonly used in patients with non-dialysis-dependent chronic kidney disease (CKD). Modern intravenous iron compounds (e.g. ferric derisomaltose (FDI), ferric carboxymaltose (FCM)) are increasingly utilized with similar efficacy. A differential effect in terms of hypophosphatemia has been noted following administration of FCM, which may be related to fibroblast growth factor 23
-
Steroid-resistant minimal change nephrotic syndrome associated with thymoma treated effectively with rituximab following thymectomy and cyclosporine: a case report BMC Nephrol. (IF 2.3) Pub Date : 2024-02-09 Yusaku Watanabe, Keiji Hirai, Momoko Hirata, Taisuke Kitano, Kiyonori Ito, Susumu Ookawara, Hisashi Oshiro, Yoshiyuki Morishita
Minimal change nephrotic syndrome (MCNS) can be complicated by thymoma; however, no standard therapy for thymoma-associated MCNS has yet been established. We herein describe a case of steroid-resistant MCNS associated with thymoma, treated effectively with rituximab. A 71-year-old Japanese man was referred to our department with severe proteinuria (20 g/gCr). Renal biopsy showed minimal change disease
-
Bioactive adrenomedullin and interleukin-6 in COVID-19: potential biomarkers of acute kidney injury and critical illness BMC Nephrol. (IF 2.3) Pub Date : 2024-02-09 Simon B. Leininger, Stephan T. Staudner, Manuel J. Vogel, Julian Mustroph, Ute Hubauer, Stefan Wallner, Petra Lehn, Ralph Burkhardt, Christine Meindl, Frank Hanses, Markus Zimmermann, Lars S. Maier, Julian Hupf, Carsten G. Jungbauer
The aim of this study was to investigate whether bioactive adrenomedullin (bio-ADM) and interleukin-6 (IL-6) are related to acute kidney injury (AKI) and severe illness in COVID-19 patients. 153 patients with COVID-19 admitted to the emergency department (ED) were included. Blood samples were collected from each patient at admission. Bio-ADM and IL-6, as well as DPP3 and routinely measured markers
-
Nephrotic syndrome with acute kidney injury due to combination therapy of immune checkpoint inhibitors: a case report and review of the literature BMC Nephrol. (IF 2.3) Pub Date : 2024-02-09 Ryosuke Saiki, Kan Katayama, Haruko Saiki, Ayumi Fukumori, Kayo Tsujimoto, Masahiro Yamawaki, Fumika Tanaka, Daisuke Takahashi, Keiko Oda, Yasuo Suzuki, Tomohiro Murata, Kaoru Dohi
Recent studies have focused on immune checkpoint inhibitors. Renal complications associated with the use of immune checkpoint inhibitors are uncommon compared with other immune-related adverse events. Acute interstitial nephritis accounts for most of these renal complications, with nephrotic syndrome quite rare. We herein report a case of nephrotic syndrome associated with immune checkpoint inhibitors
-
Quality-of-life measures and their psychometric properties used in African chronic kidney disease populations: a systematic review using COSMIN methodology BMC Nephrol. (IF 2.3) Pub Date : 2024-02-09 Moustapha Faye, Florian Manneville, Adama Faye, Luc Frimat, Francis Guillemin
If any benefit is to be derived from the use of the health-related quality of life (HRQoL) questionnaires in chronic kidney disease (CKD) patients, they should be validated and culturally adapted to the target population. We aimed to critically appraise the psychometric properties of HRQoL questionnaires used in African populations with CKD. Web of Science, Embase, PubMed and PsycINFO databases were
-
Concordance between muscle mass assessed by bioelectrical impedance analysis and by muscle ultrasound: a cross-sectional study in a cohort of patients on chronic hemodialysis BMC Nephrol. (IF 2.3) Pub Date : 2024-02-06 Eman Nagy, Emad Samaan, Mohamed El-Gamal, Muhammed Shamsuddin, Samar Tharwat
Sarcopenia is a common problem in hemodialysis (HD) patients, and it is diagnosed by low muscle mass, strength and/or low physical performance. Muscle ultrasound (US) is a non-invasive portable tool that might be used for assessment of muscle mass. The aim of the current study was to investigate the concordance between muscle US and bioelectrical impedance analysis (BIA) in diagnosis of sarcopenia
-
Effects of CYP3A4*22 and POR*28 variations on the pharmacokinetics of tacrolimus in renal transplant recipients: a meta-analysis of 18 observational studies BMC Nephrol. (IF 2.3) Pub Date : 2024-02-06 Ze Li, Xiaozhen Wang, Dandan Li, Sheng Cheng, Zhe Li, Heng Guo, Yiwen Dong, Yingming Zheng, Xingang Li
This study aimed to investigate the association between cytochrome P450 (CYP) 3A4*22 and cytochrome P450 oxidoreductase (POR)*28 variations and the pharmacokinetics of tacrolimus. Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science (SCI), MEDLINE, and Embase were systematically searched from inception to August 2022. The outcomes were weight-adjusted daily dose and dose-adjusted
-
Impact of C-reactive protein on the effect of Roxadustat for the treatment of anemia in chronic kidney disease: a systematic review of randomized controlled trials BMC Nephrol. (IF 2.3) Pub Date : 2024-02-05 Xiaoyu Luo, Guoli Li, Hongyu Yang, Lang Chen, Yinyan Gao, Jing Cong, Hui Luo, Weiru Zhang
Chronic inflammation, reflected by an increased blood C-reactive protein (CRP) level, is common in patients with chronic kidney disease (CKD) and is involved in the development of renal anemia. This systematic review aims to investigate the impacts of CRP on the efficacy of hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) in the treatment of renal anemia in patients with CKD. We conducted
-
Benefit finding in chronic kidney disease patients receiving hemodialysis: a cross-sectional study BMC Nephrol. (IF 2.3) Pub Date : 2024-02-01 Jie Yang, Hong-Li Yan, Yong-Qi Li, Lei Zhang, Xiao-Yan Qiu, Yi-He Tian, Yan-Lin Gong, Chen-Ling Luo, Jing Wu, Jing Chu
The psychological problems of hemodialysis (HD) patients are prominent, and benefit finding (BF) have been proven beneficial to physical and mental health, fewer researchers explored BF in HD patients. The aim of this study was to investigate the current status of BF in patients with chronic kidney disease and to analyze the factors influencing it in order to provide a reference for subsequent interventions
-
Examining the acceptability and feasibility of the Compassionate Mindful Resilience (CMR) programme in adults living with chronic kidney disease: the COSMIC study findings BMC Nephrol. (IF 2.3) Pub Date : 2024-01-31 Anna Wilson, Claire Carswell, Clare McKeaveney, Karen Atkinson, Stephanie Burton, Clare McVeigh, Lisa Graham-Wisener, Erika Jääskeläinen, William Johnston, Daniel O’Rourke, Joanne Reid, Soham Rej, Ian Walsh, Helen Noble
Individuals with chronic kidney disease experience difficult physical and psychological symptoms, that impact quality of life, and are at increased risk of anxiety and depression. Access to specialist psychological support is limited. This study aimed to support a new service development project, in collaboration with Kidney Care UK, to implement the Compassionate Mindful Resilience (CMR) programme
-
Assessment of the hematological profile of children with chronic kidney disease on follow-up at St. Paul’s Hospital Millennium Medical College and Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia BMC Nephrol. (IF 2.3) Pub Date : 2024-01-30 Melaku Shenkut, Fekadu Urgessa, Rahel Alemu, Bezaye Abebe
Chronic kidney disease (CKD) is a major public health issue with an increasing incidence and prevalence worldwide. In CKD, hematological parameters are influenced, and the effect increases with CKD stage. Thus, the aim of this study was to assess hematological profile of children with CKD on follow up at Tikur Anbessa Specialized Hospital and St. Paul’s Hospital Millennium Medical College in Addis