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Urinary Clusterin is a biomarker of renal epithelial senescence and predicts human kidney disease progression medRxiv. Nephrol. Pub Date : 2024-03-15 David P Baird, Maximilian Reck, Ross Campbell, Marie-Helena Docherty, Matthieu Vermeren, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Jamie P Traynor, Patrick B Mark, Katie Mylonas, Jeremy Hughes, Laura Denby, Bryan Conway, David Ferenbach
Cellular senescence drives organ fibrosis and ageing, and accumulating evidence supports the ability of senescence-depleting drugs to improve outcomes in experimental models of disease. The lack of non-invasive biomarkers represents a major obstacle to the design of human trials of candidate senolytics. On samples from 51 patients with chronic kidney disease (CKD), we performed liquid chromatography
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Adherence to a healthful plant-based diet and risk of chronic kidney disease among individuals with diabetes: A prospective cohort study medRxiv. Nephrol. Pub Date : 2024-03-15 Alysha S. Thompson, Anna Tresserra-Rimbau, Amy Jennings, Nicola P. Bondonno, Catharina J. Candussi, Joshua K. O'Neill, Claire Hill, Martina Gaggl, Aedin Cassidy, Tilman Kuhn
Background: Chronic kidney disease (CKD) is highly prevalent among people with diabetes. While identifying modifiable risk factors to prevent a decline in kidney function among those living with diabetes is pivotal, there is limited evidence on dietary risk factors for CKD. In this study we examined the associations between healthy and less healthy plant-based diets (PBDs) and the risk of CKD among
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Lupus Nephritis Subtype Classification with only Slide Level labels medRxiv. Nephrol. Pub Date : 2024-03-15 Amit Sharma, Ekansh Chauhan, Megha S Uppin, Rajasekhar Liza, C.V. Jawahar, P K Vinod
Lupus Nephritis classification has historically relied on labor-intensive and meticulous glomerular-level labeling of renal structures in whole slide images (WSIs). However, this approach presents a formidable challenge due to its tedious and resource-intensive nature, limiting its scalability and practicality in clinical settings. In response to this challenge, our work introduces a novel methodology
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Global burden of renal anemia in 204 countries and territories, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 medRxiv. Nephrol. Pub Date : 2024-03-13 Feifan Chu, Jinzhong Ji, Yuning Ma, Qing Guan, Lumin Chen, Zujie Chen, Qiwei Ji, Mingxin Sun, Hui Zhang, Haihan Song, Xiuquan Lin, Hao Zhou
Background: Renal anemia, one of the causes of anemia, has inflicted a certain degree of loss on global health. However, there are no comprehensive analyses on the burden of renal anemia yet. This study aims to comprehensively evaluate the age-standardized prevalence and Years Lived with Disability (YLDs) burden and trends of renal anemia across different sexes, ages, countries, and regions from 1990
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WITHDRAWN: Development and external validation of a practical diagnostic support tool, ′ABC2-Screener′, to predict sarcopenia among patients on maintenance haemodialysis: A multicentre cross-sectional study medRxiv. Nephrol. Pub Date : 2024-03-12 Masatoshi Matsunami, Tetsuro Aita, Tsukasa Kamitani, Yu Munakata, Atsuro Kawaji, Hiroshi Kuji, Tomo Suzuki, Noriaki Kurita
The authors have withdrawn their manuscript owing to uncorrectable data errors which were discovered after posting. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
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A Reassessment of Sodium Correction Rates and Hospital Length of Stay Accounting for Admission Diagnosis medRxiv. Nephrol. Pub Date : 2024-03-11 Eric Gottlieb, Leo Anthony Celi
Background Recent studies have challenged assumptions about slow correction of severe hyponatremia and have shown that rapid correction is associated with shorter hospital length of stay. However, the confounding effect of admission diagnosis has not been fully explored. The objective of this study was to determine whether rapid correction is still associated with shorter length of stay when controlling
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Complications and treatment of hypercalciuria in patients affected by Familial Hyperkalemic Hypertension (FHHt) medRxiv. Nephrol. Pub Date : 2024-03-10 Viola D'Ambrosio, Elizabeth Wan, Gerlineke Hawkins-van der Cingel, Keith Siew, Olivia McKnight, Pietro Manuel Ferraro, Stephen B Walsh
Background and hypothesis Gordon syndrome (also pseudohypoaldosteronism type II (PHAII) or Familial Hyperkalemia with Hypertension (FHHt)) is a genetic condition characterised by hypertension, hyperkalaemia, hyperchloraemic metabolic acidosis and hypercalciuria caused by an activation of the thiazide-sensitive sodium-chloride cotransporter (NCC, encoded by SLC12A3) in the distal convoluted tubule of
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Nephroprotective effects of cilastatin in people at risk of acute kidney injury: A systematic review and meta-analysis medRxiv. Nephrol. Pub Date : 2024-03-08 Dilaram Acharya, Fannar Ghanim, Tyrone G Harrison, Tayler D Scory, Nusrat Shommu, Paul Ronksley, Meghan J Elliott, David Collister, Matthew T James
Background: Cilastatin is an inhibitor of drug metabolism in the proximal tubule of the kidney that demonstrates nephroprotective effects in animal models. Cilastatin has been in clinical use since the 1980s in combination with the antibiotic imipenem to prevent imipenem degradation, which has enabled studies testing the effect of cilastatin on kidney outcomes in observational studies and clinical
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Multi-trait Analysis of GWAS for circulating FGF23 Identifies Novel Network Interactions Between HRG-HMGB1 and Cardiac Disease in CKD medRxiv. Nephrol. Pub Date : 2024-03-06 Farzana Perwad, Elvis Akwo, Nicholas Vartanian, Larry J Suva, Peter Friedman, Cassiane Robinson-Cohen
Background: Genome-wide association studies (GWAS) have identified numerous genetic loci associated with mineral metabolism (MM) markers but have exclusively focused on single-trait analysis. In this study, we performed a multi-trait analysis of GWAS (MTAG) of MM, exploring overlapping genetic architecture between traits, to identify novel genetic associations for fibroblast growth factor 23 (FGF23)
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Patient preferences and priorities for the design of an acute kidney injury prevention trial: Findings from a consensus workshop medRxiv. Nephrol. Pub Date : 2024-03-05 Meghan J Elliott, Kirsten Fiest, Shannan Love, Dale Birdsell, Maureena Loth, Heather Dumka, Benny Ranna, Nusrat Shommu, Eleanor Bentrud, Sarah Gil, Dilaram Acharya, Tyrone G Harrison, Neesh Pannu, Matthew T James
Background: Hospitalized patients who develop acute kidney injury (AKI) as a result of nephrotoxic medication exposure are at high risk of adverse outcomes, such as prolonged hospitalization, chronic kidney disease, and cardiovascular events. High-quality clinical trials are needed to establish the safety and efficacy of potential therapies to prevent AKI. Incorporation of the preferences of people
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Long COVID and kidney function: A scoping review protocol medRxiv. Nephrol. Pub Date : 2024-02-29 Marcella Frediani, Heitor S. Ribeiro, Geraldo Busatto, Carlos Carvalho, Emmanuel A Burdmann
Introduction: The coronavirus disease 2019 (COVID-19) pandemic had catastrophic repercussions worldwide, including short- and long-term effects on multiple organs. The term long COVID encompasses signs and symptoms associated with COVID that persist for more than two months. However, the effects of long COVID on kidney function remain poorly understood. Objective: This scoping review aims to describe
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Quantitative susceptibility mapping for detection of kidney stones, hemorrhage differentiation and cyst classification in ADPKD medRxiv. Nephrol. Pub Date : 2024-02-27 Karl Schumacher, Martin R. Prince, Jon D Blumenfeld, Hanna Rennert, Zhongxiu Hu, Hreedi Dev, Yi Wang, Alexey V. Dimov
Background and purpose The objective is to demonstrate feasibility of quantitative susceptibility mapping (QSM) in autosomal dominant polycystic kidney disease (ADPKD) patients and to compare imaging findings with traditional T1/T2w magnetic resonance imaging (MRI). Methods Thirty-three consecutive patients (11 male, 22 female) diagnosed with ADPKD were initially selected. QSM images were reconstructed
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The burden of patient healthcare activity in the first year of peritoneal dialysis medRxiv. Nephrol. Pub Date : 2024-02-20 Kirsty Crowe, Eleanor C Murray, Joan MacLeod, Jamie P Traynor, Peter C Thomson
Background: The healthcare-related burden associated with kidney replacement therapy (KRT) has not been characterised as comprehensively in peritoneal dialysis (PD) as in haemodialysis (HD) or kidney transplantation. This study aimed to capture the nature and extent of healthcare activity in the first year of PD therapy. Methods: Retrospective analysis was undertaken on consecutive incident adult patients
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Quantifying variant contributions in cystic kidney disease using national-scale whole genome sequencing medRxiv. Nephrol. Pub Date : 2024-02-19 Omid Sadeghi-Alavijeh, Melanie MY Chan, Gabriel Doctor, Catalin Voinescu, Alex Stuckey, Athanasios Kousathanas, Alexander Ho, Genomics England Research Consortium, Horia Stanescu, Horia Stanescu, Detlef Bockenhauer, Richard Sandford, Adam P Levine, Daniel P Gale
Introduction Cystic kidney disease (CyKD) is frequently a familial disease, with ~85% of probands receiving a monogenic diagnosis. However, gene discovery has been led by family-based and candidate gene studies, limiting the ascertainment of non-Mendelian genetic contributors to the disease. Using whole genome sequencing data provided by the 100,000 Genomes Project (100KGP), we used hypothesis-free
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Prevalence of Mendelian kidney disease among patients with high-risk APOL1 genotypes undergoing commercial genetic testing in the United States medRxiv. Nephrol. Pub Date : 2024-02-14 Ronaldo da Silva Francisco, Sumit Punj, Lisa Vincent, Nina Sanapareddy, Vivek Bhalla, Glenn M. Chertow, Dianne Keen-Kim, Vivek Charu
Background: Among individuals with high-risk APOL1 genotypes, the lifetime risk of developing kidney failure is ~15%, indicating that other genetic variants or non-genetic modifiers likely contribute substantially to an individual patient's risk of progressive kidney disease. Here we estimate the prevalence and distribution of molecularly diagnosed Mendelian kidney diseases among patients with high-risk
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Spatial Multi-Omics Connect SHROOM3 and COL18A1 in Chronic Kidney Disease medRxiv. Nephrol. Pub Date : 2024-02-11 Pukhraj S. Gaheer, Nikhil Uppal, Amy Paul, Pedrum Mohammadi-Shemirani, Nicolas Perrot, Guillaume Pare, Darren Bridgewater, Matthew B. Lanktree
Shroom Family Member 3 (SHROOM3) encodes an actin-binding protein that impacts kidney development. Genome-wide association studies (GWAS) identified CKD-associated common variants around SHROOM3 and Shroom3 knock-out mice develop glomerular abnormalities. We sought to evaluate the impact of genetically predicted SHROOM3 expression on kidney traits and the circulating proteome, and validate findings
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Acute kidney injury outcomes of COVID-19 confirmed patients in a Philippine tertiary hospital: A retrospective study medRxiv. Nephrol. Pub Date : 2024-02-06 Joberly Sayson, Reginald Kalaw, Bernadette Ecunar Ordona, Marissa Elizabeth Lim
The novel coronavirus (COVID-19) is known to be the fifth pandemic causing massive deaths worldwide. This virus has not only been deeply associated with acute respiratory distress, but also acute kidney injury (AKI). This study describes the baseline characteristics and various outcomes of AKI based on the KDIGO 2012 Clinical Practice Guidelines in patients hospitalized with COVID-19 at a Philippine
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A web-based tool for real-time adequacy assessment of kidney biopsies medRxiv. Nephrol. Pub Date : 2024-02-05 Meysam Ahangaran, Emily Sun, Khang Le, Jiawei Sun, William Wang, Tian Herng Tan, Lyle Burdine, Zeljko Dvanajscak, Clarissa Cassol, Shree Sharma, Vijaya B Kolachalama
The escalating incidence of kidney biopsies providing insufficient tissue for diagnosis poses a dual challenge, straining the healthcare system and jeopardizing patients who may require re-biopsy or face the prospect of an inaccurate diagnosis due to an unsampled disease. Here, we introduce a web-based tool that can provide real-time, quantitative assessment of kidney biopsy adequacy directly from
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Clinical Predictors of Long-term Outcomes in C3 Glomerulopathy and Immune-Complex Membranoproliferative Glomerulonephritis within the UK RaDaR Registry medRxiv. Nephrol. Pub Date : 2024-02-04 Sherry Masoud, Katie Wong, Lewis Downward, David Pitcher, Nicholas J.A. Webb, Clare Proudfoot, RaDaR Consortium, Edwin K.S. Wong, Daniel P. Gale
Background C3 glomerulopathy (C3G) and immune-complex membranoproliferative glomerulonephritis (IC-MPGN) are rare disorders that often result in kidney failure over the long-term. While there is much interest in the therapeutic potential of complement inhibition, the limited duration and necessarily small size of controlled trials, means there is a need to define how well short-term changes in eGFR
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Relationship between fill volume and transport in peritoneal dialysis medRxiv. Nephrol. Pub Date : 2024-01-31 Carl Mikael Oberg
Introduction: Larger fill volumes in peritoneal dialysis (PD) typically improve small solute clearance and water removal, and vice versa – but the relationship between intra-peritoneal volume and the capacities for solute and water transport in PD has been little studied. Here, it is proposed that this relative relationship is described by a simple ratio (Volumenew/Volumeold)2/3 up to a critical break-point
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Data Driven Approach to Characterize Rapid Decline in Autosomal Dominant Polycystic Kidney Disease medRxiv. Nephrol. Pub Date : 2024-01-28 John J Sim, Yu-Hsiang Shu, Simran K. Bhandari, Qiaoling Chen, Teresa N. Harrison, Min Young Lee, Mercedes A. Munis, Kerresa Morrissette, Shirin Sundar, Kristin Pareja, Ali Nourbakhsh, Cynthia J. Willey
Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disease with high phenotypic variability. Insights into ADPKD progression could lead to earlier detection and management prior to end stage kidney disease (ESKD). We sought to identify patients with rapid decline (RD) in kidney function and to determine clinical factors associated with RD using a data-driven approach
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The effects of intermittent or continuous exercise on renal haemodynamics during moderate-intensity exercise medRxiv. Nephrol. Pub Date : 2024-01-26 Shotaro Kawakami, Tetsuhiko Yasuno, Saki Kawakami, Ai Ito, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Kosuke Masutani, Yoshinari Uehara, Yasuki Higaki, Ryoma Michishita
Purpose Moderate-intensity exercise has beneficial effects for individuals with CKD. However, it is unclear whether intermittent exercise (IE) has a different effect on renal haemodynamics compared to continuous exercise (CE). This study aimed to compare the effects of intermittent or continuous exercise on renal haemodynamics and renal injury during moderate-intensity exercise. Methods Ten males underwent
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Potential therapeutic targets for Membranous Nephropathy: Muti-omics Mendelian randomization and colocalization analysis medRxiv. Nephrol. Pub Date : 2024-01-23 Zhihang Su, Wen Liu, Zheng Yin, Di Wu, Yuan Cheng, Qijun Wan
Background: The currently available medications for treating membranous nephropathy (MN) still have unsatisfactory efficacy in inhibiting disease recurrence, slowing down its progression, and even halting the development of end-stage renal disease. There is still a need to develop novel drugs targeting MN. Methods: We utilized summary statistics of MN from the Kiryluk Lab and obtained plasma proteins
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Inferring Alzheimer’s disease pathologic traits from clinical measures in living adults medRxiv. Nephrol. Pub Date : 2024-01-20 Jingjing Yang, Xizhu Liu, Shahram Oveisgharan, Andrea R. Zammit, Sukriti Nag, David A Bennett, Aron S Buchman
Background Alzheimer’s disease neuropathologic changes (AD-NC) are important for identify people with high risk for AD dementia (ADD) and subtyping ADD.
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Routine Labs in Hospital Patients: Iatrogenic Anemia and Missed Acute Kidney Injury medRxiv. Nephrol. Pub Date : 2024-01-17 Dawson Dean
Guidelines recommend avoiding unnecessary laboratory tests to minimize risks of anemia in hospitalized patients as well as reduce costs. Avoiding routine labs, however, may introduce new risks of missing conditions that do not have physical exam or history findings, such as Acute Kidney Injury. This study analyzes retrospective data for routine laboratory results and simulates different strategies
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Kidney Replacement Therapy in COVID-19-Related Acute Kidney Injury: the Importance of Timing medRxiv. Nephrol. Pub Date : 2024-01-15 Carlos Augusto Pereira de Almeida, Marcia Fernanda Arantes de Oliveira, Alexandre Macedo Teixeira, Carla Paulina Sandoval Cabrera, Igor Smolentzov, Bernardo Vergara Reichert, Paulo Ricardo Gessolo Lins, Camila Eleuterio Rodrigues, Victor Faria Seabra, Lucia Andrade
The objective of this study was to evaluate two different criteria for deciding when KRT should be initiated in patients with COVID-19-related AKI, as well as to determine the impact of the timing of KRT, as defined by each criterion, on in-hospital mortality among such patients. This was a retrospective study involving 512 adult patients admitted to the ICU. All participants had laboratory-confirmed
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Effects of changes in calculating GFR using KDIGO standards: Discordance in the Staging and Timing of Diagnosis of Chronic Kidney Disease medRxiv. Nephrol. Pub Date : 2024-01-03 Charlotte Baker, Samuel Gratzl, Patricia J Rodriguez, Michael Simonov, Brianna M Goodwin Cartwright, Rajdeep Brar, Nicholas L Stucky
Introduction Chronic kidney disease (CKD) is a highly prevalent disease with disparities in diagnosis and treatment. Until recently, primary diagnosis for CKD was based on equations that incorporated race and have demonstrated racial bias. This study had two aims comparing outcomes for Black patients and their counterparts: 1) whether using the new 2021 CKD-EPI equation led to decreased disparity with
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The decline of renal function aggravates arterial stiffness: a large-scale cross-sectional and longitudinal study medRxiv. Nephrol. Pub Date : 2024-01-02 Qiuping Zhao, Wei Wang, Yiming Leng, Jie Wang, Miao Rujia, Zhiheng Chen, Jiangang Wang, Jingjing Cai, Hong Yuan, Fei Li, Yao Lu
Purpose Many studies investigated the one-single-direction relationship between arterial stiffness and chronic kidney dysfunction, particularly in patients with end-stage renal disease. The bidirectional relevance between kidney function decline and arterial stiffness in general population remains unknown. This study aimed to address the temporary relationship between arterial stiffness and renal function
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Effectivity and Safety Profile of Tenapanor, a Sodium-Hydrogen Exchanger Isoform 3 Inhibitor, as an Innovative Treatment for Hyperphosphatemia in Chronic Kidney Disease, a Systematic Review of Clinical Studies medRxiv. Nephrol. Pub Date : 2023-12-19 WILLIAM SUCIANGTO, Haerani Rasyid, Anastasya Angelica Vicente, Winny Suciangto
Abstract Background: Chronic kidney disease (CKD) is a major global health problem. Hyperphosphatemia is frequent in CKD and a reason for increased morbidity and mortality as it generates hyperparathyroidism, high fibroblast growth factor 23 (FGF23), and hypocalcemia. Available hyperphosphatemia therapies still have limitations, including risk of metal overload, cardiovascular calcification, and systemic
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Predictive Model for Severe Coronary Artery Calcification in ESKD Patients medRxiv. Nephrol. Pub Date : 2023-12-17 Xinfang Tang, Hanyang Qian, Ming Zeng, Hui Huang, Shijiu Lu, Jing Wang, Fan Li, Anning Bian, Xiaoxue Ye, Guang Yang, Kefan Ma, Changying Xing, Yi Xu, Ningning Wang
Introduction The Agatston coronary artery calcification score (CACS) is an assessment index for coronary artery calcification (CAC). This study aims to explore the characteristics of CAC in end-stage kidney disease (ESKD) patients and establish a predictive model to assess the risk of severe CAC in patients.
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Association Between Person-Centered Care Quality and Advance Care Planning Participation in Patients Undergoing Hemodialysis: A Multicenter Cross-Sectional Study medRxiv. Nephrol. Pub Date : 2023-12-17 Yusuke Kanakubo, Noriaki Kurita, Mamiko Ukai, Tetsuro Aita, Ryohei Inanaga, Atsuro Kawaji, Takumi Toishi, Masatoshi Matsunami, Yu Munakata, Tomo Suzuki, Tadao Okada
Rationale & Objective Person-centered care (PCC), which incorporates patients’ preferences and values not only for medical care but also for their life, in decision making has been proposed for promoting advance care planning (ACP) among patients with kidney failure.
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Impaired incretin homeostasis in non-diabetic moderate-severe chronic kidney disease medRxiv. Nephrol. Pub Date : 2023-12-18 Armin Ahmadi, Jorge Gamboa, Jennifer E. Norman, Byambaa Enkhmaa, Madelynn Tucker, Brian J. Bennett, Leila R. Zelnick, Sili Fan, Lars F. Berglund, Talat Alp Ikizler, Ian H. de Boer, Bethany P. Cummings, Baback Roshanravan
Background: Incretins are regulators of insulin secretion and glucose homeostasis that are metabolized by dipeptidyl peptidase-4 (DPP-4). Moderate-severe CKD may modify incretin release, metabolism, or response. Methods: We performed 2-hour oral glucose tolerance testing (OGTT) in 59 people with non-diabetic CKD (eGFR<60 ml/min per 1.73 m2) and 39 matched controls. We measured total (tAUC) and incremental
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Circulating inflammatory proteins may be potential drug targets for Idiopathic Membranous Nephropathy: proteome-wide Mendelian Randomization and colocalization analysis medRxiv. Nephrol. Pub Date : 2023-12-13 Zhihang Su, Qingqing Rao, Di Wu, Zheng Yin, Wen Liu, Qijun Wan
Background Idiopathic membranous nephropathy (IMN) is a predominant cause of nephrotic syndrome among adults. Existing drugs are ineffective in about one-third of IMN patients, and the high recurrence rate makes them far from satisfactory. Therefore, it is imperative to find new therapeutic targets for membranous nephropathy. Circulating inflammatory proteins in plasma have been found to be related
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Telemedicine Perspectives of Patients with Non-Dialysis Kidney Disease and Kidney Transplant - A Qualitative Meta-Analysis medRxiv. Nephrol. Pub Date : 2023-12-08 Christopher D. Manko, Benjamin J. Apple, Alexander R. Chang, Bobbie L. Johannes
Rationale & Objective: While the use of telemedicine has increased dramatically across disciplines, patient perspectives on telemedicine related to chronic kidney disease are not well understood. We systematically reviewed qualitative studies on patients with chronic kidney disease to better understand these patients' perspectives related to telemedicine. Study Design: Qualitative Meta–Analysis Setting
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Bone mineral density assessment in patients with cystinuria medRxiv. Nephrol. Pub Date : 2023-12-08 Viola D'Ambrosio, Giovanna Capolongo, Chiara Caletti, Maria Teresa Vietri, Martina Ambrogio, Gianmarco Lombardi, Alessandra Perna, Giuseppe Orefice, Elisa Gremese, Valentina Varriano, Davide Gatti, Angelo Fassio, Giovambattista Capasso, Giovanni Gambaro, Pietro Manuel Ferraro
Introduction Cystinuria is a rare genetic disease characterized by impaired tubular transport of cystine. Clinical features of cystinuria include mainly nephrolithiasis and its complications, although cystinuric patients may present with other comorbidities. There are currently no data on bone features of patients with cystinuria. Our aim is to characterize bone mineral density (BMD) in cystinuria
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Analysis of potential iron toxicity in hemodialysis patients under intravenous iron treatment medRxiv. Nephrol. Pub Date : 2023-12-07 Jessy Korina Peña Esparragoza, Alina Chávez Guillén, Paloma Ramos López, Oscar Rueda Elias, Susana López Ongil, Matilde Alique, Rafael Ramírez-Chamond, Julia Carracedo, Diego Rodriguez-Puyol, Patricia Martínez-Miguel
Background: The use of higher doses of iron for the treatment of anemia in hemodialysis patients allows lower doses of erythropoiesis-stimulating agents; however, there are concerns regarding the risk of iron toxicity. This study aimed to evaluate the potential toxicity of iron deposition in prevalent hemodialysis patients on iron therapy and its relationship with parameters used to assess iron status
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The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease medRxiv. Nephrol. Pub Date : 2023-12-04 Abigail O. Smith, William Tyler Frantz, Kenley M. Preval, Yvonne J.K. Edwards, Craig J. Ceol, Julie A. Jonassen, Gregory J. Pazour
Polycystic kidney disease (PKD) is an important cause of end stage renal disease, but treatment options are limited. While later stages of the disease have been extensively studied, mechanisms driving the initial conversion of renal tubules into cysts are not understood. To identify factors that promote the initiation of cysts we deleted polycystin-2 (Pkd2) in mice and surveyed transcriptional changes
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Causality between Peripheral Immune Cell Counts and Membranous Nephropathy: A Bidirectional Mendelian Randomization Study medRxiv. Nephrol. Pub Date : 2023-11-27 Zhihang Su, Liu Wen, Xiangning Feng, Qijun Wan
Background Membranous nephropathy (MN), an autoimmune disease, has not yet been fully elucidated regarding its relationship with immune cells.
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The National Registry of Rare Kidney Diseases (RaDaR): Description, recruitment, and cross-sectional analyses of 25,880 adults and children with rare kidney diseases in the UK medRxiv. Nephrol. Pub Date : 2023-11-25 Katie Wong, David Pitcher, Fiona Braddon, Lewis Downward, Retha Steenkamp, Nicholas Annear, Jonathan Barratt, Coralie Bingham, Richard J. Coward, Tina Chrysochou, David Game, Sian Griffin, Matt Hall, Sally Johnson, Durga Kanigicherla, Fiona Karet Frankl, David Kavanagh, Larissa Kerecuk, Eamonn R. Maher, Shabbir Moochhala, Jenny Pinney, John A. Sayer, Roslyn Simms, Smeeta Sinha, Shalabh Srivastava,
Rare kidney diseases are not well characterised, despite making a significant contribution to the burden of kidney disease globally. The National Registry of Rare Kidney Diseases (RaDaR) collects longitudinal disease and treatment-related data from people living with rare kidney diseases across the UK, and is the largest rare kidney disease registry in the world. We present the clinical demographics
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IDENTIFICATION OF MODIFIER GENE VARIANTS OVERREPRESENTED IN FAMILIAL HYPOMAGNESEMIA WITH HYPERCALCIURIA AND NEPHROCALCINOSIS PA-TIENTS WITH A MORE AGGRESSIVE RENAL PHENOTYPE medRxiv. Nephrol. Pub Date : 2023-11-09 Monica Vall-Palomar, Jordi Morata, Monica Duran, Julieta Torchia, Raul Tonda, Mireia Ferrer, Alex Sanchez, Gerard Cantero, Gema Ariceta, Anna Meseguer, Cristina Martinez
Inter- and intra-familial phenotypic variability is a common observation in genetic diseases. In this study we have gathered a highly unique patient cohort suffering from an ultra-rare renal disease, familial hypomag-nesemia with hypercalciuria and nephrocalcinosis, with a deep clinical and genetic characterization. In this cohort, we have previously reported a high phenotypic variability between patients
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Prevalence and characteristics of genetic disease in adult kidney stone formers medRxiv. Nephrol. Pub Date : 2023-11-07 Manuel A Anderegg, Eric G Olinger, Matteo Bargagli, Robert Geraghty, Lea Pohlmeier, Alexander Nater, Remy Bruggmann, John A Sayer, Bruno Vogt, Andre Schaller, Daniel G Fuster
Background: Molecular mechanisms of kidney stone formation remain unknown in most patients. Previous studies showed high heritability of nephrolithiasis, but data on prevalence and characteristics of genetic disease in unselected adults with nephrolithiasis are lacking. Methods: We performed whole exome sequencing in 787 participants of the Bern Kidney Stone Registry, an unselected cohort of adults
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Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV2 Infection medRxiv. Nephrol. Pub Date : 2023-10-27 Pushkala Jayaraman, Madhumitha Rajagopal, Ishan Paranjpe, Lora Liharska, Mayte Suarez-Farinas, Ryan Thompson, Diane Marie Del Valle, Noam Beckmann, Wonsuk Oh, Faris F Gulamali, Justin Kauffman, Edgar Gonzalez-Kozlova, Sergio Dellepiane, George Vasquez-Rios, Akhil Vaid, Joy Jiang, Annie Chen, Ankit Sakhuja, Steven Chen, Ephraim Kenigsberg, John Cijiang He, Steven G Coca, Lili Chan, Eric Schadt, Miram
Background. Acute kidney injury (AKI) is common in hospitalized patients with SARS-CoV2 infection despite vaccination and leads to long-term kidney dysfunction. However, peripheral blood molecular signatures in AKI from COVID-19 and their association with long-term kidney dysfunction are yet unexplored. Methods. In patients hospitalized with SARS-CoV2, we performed bulk RNA sequencing using peripheral
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A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease medRxiv. Nephrol. Pub Date : 2023-10-13 Andrea Eoli, Susanne Ibing, Claudia Schurmann, Girish Nadkarni, Henrike O Heyne, Erwin Bottinger
Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney function, affecting approximately 9.1% of the world's population. Here, we use a soft-clustering algorithm to deconstruct its genetic heterogeneity. First, we selected 322 CKD-associated independent genetic variants from published genome-wide association studies (GWAS) and added association results for 229 traits
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Application of self-reporting, clinicians assessment, and tacrolimus trough levels in evaluating adherence to immunosuppressive therapy in kidney transplant recipients. A cohort study. medRxiv. Nephrol. Pub Date : 2023-10-09 Choki Dorji, Tashi Tobgay, Kesara Na-Bangchang
Abstract Introduction Immunosuppressants are drugs with narrow therapeutic indices and pharmacokinetic variation. Nonadherence to the therapy will cause over or underexposure leading to graft rejection. Methods A cohort study was conducted on kidney transplant recipients from the nephrology clinic and therapeutic drug monitoring unit. Patients were asked to self-report their medication adherence using
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A model-driven machine learning approach for personalized kidney graft risk prediction medRxiv. Nephrol. Pub Date : 2023-10-02 Symeon Savvopoulos, Irina Scheffner, Andreas Reppas, Wilfried Gwinner, Haralampos Hatzikirou
Graft failure after renal transplantation is a multifactorial process. Predicting the risk of graft failure accurately is imperative since such knowledge allows for identifying patients at risk and treatment personalization. In this study, we were interested in predicting the temporal evolution of graft function (expressed as estimated glomerular filtration rate; eGFR) based on pre-transplant data
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Cell Catcher: a new method to extract and preserve live renal cells from urine. medRxiv. Nephrol. Pub Date : 2023-09-24 Katia Nazmutdinova, Cheuk Yan Man, Martyn Carter, Philip L Beales, Paul JD Winyard, Stephen B Walsh, Karen L Price, David A Long
Patient-specific urine-derived cells are valuable tools for biomedical research and personalised medicine since collection is non-invasive and easily repeated, unlike biopsies. The full potential of urine-derived cells remains untapped, however, due to the short shelf life of samples and necessity for prompt centrifugation. This study aims to address this limitation by evaluating a novel filtration-based
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Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: The Japan Specific Health Checkups (J SHC) Study medRxiv. Nephrol. Pub Date : 2023-09-24 Hiroyuki Tamaki, Masahiro Eriguchi, Hisako Yoshida, Takayuki Uemura, Hikari Tasaki, Riri Furuyama, Fumihiro Fukata, Masatoshi Nishimoto, Takaaki Kosugi, Masaru Matsui, Ken-ichi Samejima, Kunitoshi Iseki, Shouichi Fujimoto, Tsuneo Konta, Toshiki Moriyama, Kunihiro Yamagata, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe, Kazuhiko Tsuruya
Background: Unlike systolic blood pressure (SBP), the prognostic value of diastolic blood pressure (DBP) in kidney function has not been established. We hypothesized that pulse pressure (PP), which is associated with arteriosclerosis, would affect the prognostic value of DBP. Methods: This longitudinal study used data from the Japan Specific Health Checkups Study conducted between 2008 and 2014. The
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Hospital-Acquired Acute Kidney Injury in Non-critical Medical Patients in a Developing Country Tertiary Hospital: Incidence and Predictors medRxiv. Nephrol. Pub Date : 2023-09-22 Nahom Dessalegn Mekonnen, Tigist Workneh Leulseged, Buure Ayderuss Hassen, Kidus Haile Yemaneberhan, Helen Surafeal Berhe, Nebiat Adane Mera, Anteneh Abera Beyene, Lidiya Zenebe Getachew, Birukti Gebreyohannes Habtezgi, Feven Negasi Abriha
Background: Acute kidney injury (AKI) is a frequent complication in critical patients leading to worse prognosis. Although the consequences of AKI are worse among critical patients, AKI is also associated with less favorable outcomes in non-critical patients. Hence, understanding the magnitude of the problem in these patients is crucial, yet there is a scarcity of evidence in non-critical settings
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Effect of Acute Kidney Injury on In-hospital Mortality in Non-critical Medical Patients in a Sub-Saharan African Country medRxiv. Nephrol. Pub Date : 2023-09-21 Nahom Desalegn Mekonnen, Tigist Workneh Leulseged, Nebiat Adane Mera, Helen Surafeal Berhe, Anteneh Abera Beyene, Kidus Haile Yemaneberhan, Buure Ayderuss Hassen, Feven Negasi Abriha, Lidiya Zenebe Getachew, Birukti Gebreyohannes Habtezgi
Background: AKI is a major global public health problem that affects millions of people each year and has been linked to poor prognosis in critically ill patients. As being a common complication in hospitalized patients, understanding its effect on non-critical patients is equally crucial, but there is a paucity of knowledge in this area, particularly in Africa. Therefore, the aim of this study was
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Enhancing Kidney Failure Analysis: Web Application Development for Longitudinal Trajectory Clustering medRxiv. Nephrol. Pub Date : 2023-09-14 Yuan Gu, Yishu Gong, Mingyue Wang, Song Jiang, Chen Li, Zheng Yuan
Kidney failure is a critical health condition with significant impact on patient well-being and healthcare systems worldwide. Analyzing the longitudinal trajectory of kidney function is crucial for understanding disease progression, predicting outcomes, and personalizing treatment strategies. This paper proposes a novel approach utilizing latent longitudinal trajectory clustering techniques by incorporating
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Deep learning on electronic medical records identifies distinct subphenotypes of diabetic kidney disease driven by genetic variations in the Rho pathway medRxiv. Nephrol. Pub Date : 2023-09-07 Ishan Paranjpe, Xuan Wang, Nanditha Anandakrishnan, Jonathan Haydak, Tielman T Van Vleck, Stefanie Defronzo, Zhengzhe Li, Anthony Mendoza, Ruijie Liu, Jia Fu, Iain Forrest, Weibin Zhou, Kyung Lee, Ross O'Hagan, Sergio Dellepiane, Kartikeya Menon, Faris Gulamali, Samir Kamat, Gabriele Luca Gusella, Alexander William Charney, Ira Hofer, Judy Cho, Ron Do, Benjamin Glicksberg, John He, Girish Nadkarni
Kidney disease affects 50% of all diabetic patients; however, prediction of disease progression has been challenging due to inherent disease heterogeneity. We use deep learning to identify novel genetic signatures prognostically associated with outcomes. Using autoencoders and unsupervised clustering of electronic health record data on 1,372 diabetic kidney disease patients, we establish two clusters
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The mediating role of trust in physicians on the association between multidimensional health literacy and medication adherence in hemodialysis: A cross-sectional study medRxiv. Nephrol. Pub Date : 2023-09-06 Ryohei Inanaga, Tatsunori Toida, Tetsuro Aita, Yusuke Kanakubo, Mamiko Ukai, Takumi Toishi, Atsuro Kawaji, Masatoshi Matsunami, Tadao Okada, Yu Munakata, Tomo Suzuki, Noriaki Kurita
Rationale & Objective: Basic health literacy (HL) and trust in physicians can influence medication adherence (MA) in dialysis patients. However, how high-order HL is associated with MA, and how trust in physicians mediates this association remain unclear. We assessed the interrelationships between HL, trust in physicians, and MA, and investigated the mediating role of trust in physicians in the relationship
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GLOBAL PREVALENCE OF DEPRESSION IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS medRxiv. Nephrol. Pub Date : 2023-09-04 Oluseyi Ademola Adejumo, Imuetinyan Rashida Edeki, Oyedepo Dapo, Joshua Falade, Olawale Elijah Yisau, Olanrewaju Olumide Ige, Adedayo Oluwadamilola Adesida, Hansel Palencia, Ayman Sabri Moussa, Jibril Abdulmalik, Jean Jacques Noubiap, Udeme Ekpenyong Ekrikpo
Chronic kidney disease, CKD, is commonly associated with psychosocial problems, especially depression, contributing to poor overall outcomes in CKD patients. Depression has not been given adequate priority in the management of CKD despite its significant adverse impact. This systematic review and meta-analysis determined the pooled prevalence of clinical depression in the global CKD population and
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Upregulation of ARHGAP9 is correlated with poor prognosis and immune infiltration in clear cell renal cell carcinoma medRxiv. Nephrol. Pub Date : 2023-09-03 Yu-ling Xiong, Chao Peng, Yue Tian
Background Rho GTPase Activating Protein (ARHGAP) family genes play critical roles in the onset and progression of human cancer. Rho GTPase Activating Protein 9 (ARHGAP9) is upregulated in various tumors. However, far too little attention has been paid to the prognostic value of ARHGAP9 and correlation with immune infiltration in clear cell renal cell carcinoma. Our aim is to evaluate the prognostic
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The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development medRxiv. Nephrol. Pub Date : 2023-08-29 Dipender Gill, Loukas Zagkos, Rubinder Gill, Thomas Benzing, Jens Jordan, Andreas Birkenfeld, Stephen Burgess, Grit Zahn
Background: Solute carrier family 13 member 5 (SLC13A5) is a Na+-coupled citrate co-transporter that mediates the entry of extracellular citrate into the cytosol. SLC13A5 inhibition has been proposed as a therapeutic target for reducing progression of kidney disease via its effects on citrate metabolism. However, evidence of its efficacy in humans is limited. The aim of this study was to leverage the
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Prognostic Utility of Total Kidney Volume for Chronic Kidney Disease Risk Prediction: An Observational and Mendelian Randomization Study medRxiv. Nephrol. Pub Date : 2023-08-28 Jianhan Wu, Yifan Wang, Caitlyn Vlasschaert, Ricky Lali, James Feiner, Pukhraj Gaheer, Serena Yang, Nicolas Perrot, Michael Chong, Matthew B. Lanktree, Guillaume Paré
Importance: Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of causal inference and prognostic utility beyond traditional biomarkers are lacking. Objective: To investigate the observational and Mendelian randomization (MR) association of TKV with kidney and cardiovascular traits and assess improvement in CKD risk prediction when TKV is added to
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Incidence of CKD and Death among Reproductive Age Women with Dialysis Requiring Acute Kidney Injury in Ethiopia: The Role of Obstetric Risk Factors medRxiv. Nephrol. Pub Date : 2023-08-24 Ayantu Tesfaye Lemma, Tigist Workneh Leulseged, Tsion Andrias Lechebo, Sisima kornelios Osman, Delayehu Workneh Bekele
Background: Obstetric risk factors are among the leading preventable causes of Acute Kidney Injury (AKI) in hospitalized reproductive age women. Obstetric-related AKI (ORAKI) has been linked to a significant increase in the overall burden of AKI in resource-constrained settings, resulting in poor maternal and perinatal outcomes. As a result, understanding the impact of these factors on the progression
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Sex differences in the diagnosis of advanced cancer and subsequent outcome in people with chronic kidney disease: an analysis of a national population cohort medRxiv. Nephrol. Pub Date : 2023-08-24 Richard Shemilt, Michael Kenneth Sullivan, Peter Hanlon, Bhautesh Dinesh Jani, Nicole De La Mata, Brenda Maria Rosales, Benjamin MP Elyan, Melanie Wyld, James Alan Hedley, Rachel Cutting, David A McAllister, Angela C Webster, Patrick B Mark, Jennifer S Lees
Background In the general population, advanced cancer stage at presentation is associated with poorer health outcomes. People with chronic kidney disease (CKD) have increased incidence and mortality from most cancer types. We sought to determine whether people with CKD were more likely to present with advanced stage cancer, whether this was associated with survival, and whether these associations varied
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Re-emergent Tremor during stable posture in Parkinson's Disease: Evidence of Pathological Beta and Prokinetic Gamma Activity medRxiv. Nephrol. Pub Date : 2023-08-24 Hao Ding, Bahman Nasseroleslami, Daniela Mirzac, Jens Volkmann, Gunter Deuschl, Sergiu Groppa, Muthuraman Muthuraman
Re-emergent tremor (RET) during stable posture in Parkinson's disease (PD) is characterized as a continuation of resting tremor (RT) and is often highly therapy refractory. The pathophysiology of both RT and RET is linked to deficits in cerebello-cortical circuits and dopaminergic depletion. However, it remains unclear how these two types of tremors differ functionally. The aim of this study is to
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Defining the molecular correlate of arteriolar hyalinosis in kidney disease progression by integration of single cell transcriptomic analysis and pathology scoring medRxiv. Nephrol. Pub Date : 2023-08-23 Rajasree Menon, Edgar A. Otto, Laura Barisoni, Ricardo Melo Ferreira, Christine P. Limonte, Bradley Godfrey, Felix Eichinger, Viji Nair, Abhijit S. Naik, Lalita Subramanian, Vivette D'Agati, Joel M. Henderson, Leal Herlitz, Krzysztof Kiryluk, Dennis G. Moledina, Gilbert W. Moeckel, Paul M. Palevsky, Chirag R. Parikh, Parmjeet Randhawa, Sylvia E. Rosas, Avi Z. Rosenberg, Isaac Stillman, Robert Toto
Arteriolar hyalinosis in kidneys is an independent predictor of cardiovascular disease, the main cause of mortality in chronic kidney disease (CKD). The underlying molecular mechanisms of protein accumulation in the subendothelial space are not well understood. Using single cell transcriptomic data and whole slide images from kidney biopsies of patients with CKD and acute kidney injury in the Kidney