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Efficacy and safety of FDG-PET for determining target volume during intensity-modulated radiotherapy for head and neck cancer involving the oral level Eur. J. Hybrid Imaging Pub Date : 2024-03-15 Yasuo Kosugi, Keisuke Sasai, Naoya Murakami, Tatsuki Karino, Yoichi Muramoto, Terufumi Kawamoto, Masaki Oshima, Noriyuki Okonogi, Jun Takatsu, Kotaro Iijima, Shuhei Karube, Akira Isobe, Naoya Hara, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Koji Murakami, Naoto Shikama
To determine the efficacy and safety of target volume determination by 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) for intensity-modulated radiation therapy (IMRT) for locally advanced head and neck squamous cell carcinoma (HNSCC) extending into the oral cavity or oropharynx. We prospectively treated 10 consecutive consenting patients with HNSCC using IMRT, with
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Baseline and early response 2-[18F]FDG-PET/MRI for prediction of radiotherapy outcome in uterine cervical squamous cell carcinoma: a prospective single-center observational cohort study Eur. J. Hybrid Imaging Pub Date : 2024-03-01 Sara Strandberg, Joakim Jonsson, Maryam Zarei, Kristina Aglund, Lennart Blomqvist, Karin Söderkvist
Should early response imaging predict tumor response to therapy, personalized treatment adaptations could be feasible to improve outcome or reduce the risk of adverse events. This prospective single-center observational study on 2-fluorine-18-fluoro-deoxy-glucose (2-[18F]FDG) positron-emission tomography/magnetic resonance imaging (PET/MRI) features aims to investigate the association between semantic
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A systematic review of the challenges, emerging solutions and applications, and future directions of PET/MRI in Parkinson’s disease Eur. J. Hybrid Imaging Pub Date : 2024-02-14 Isabella Hoi Kei Leung, Mark William Strudwick
PET/MRI is a hybrid imaging modality that boasts the simultaneous acquisition of high-resolution anatomical data and metabolic information. Having these exceptional capabilities, it is often implicated in clinical research for diagnosing and grading, as well as tracking disease progression and response to interventions. Despite this, its low level of clinical widespread use is questioned. This is especially
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Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study Eur. J. Hybrid Imaging Pub Date : 2024-02-05 Yukinori Okada, Tatsuhiko Zama, Tomohiro Itonaga, Ryuji Mikami, Mitsuru Okubo, Shinji Sugahara, Motoki Nakai, Koichiro Abe, Mana Yoshimura, Kazuhiro Saito
Research on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in small cell lung cancer is limited. Therefore, this study aimed to investigate the relationship between positron emission tomography–computed tomography (PET–CT) accumulation at hypothalamic/pituitary regions, tumor activity, and NSE level in limited-stage small cell
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18F-FACBC and 18F-FDG PET/MRI in the evaluation of 3 patients with primary central nervous system lymphoma: a pilot study Eur. J. Hybrid Imaging Pub Date : 2024-01-31 Trine Husby, Knut Johannessen, Erik Magnus Berntsen, Håkon Johansen, Guro Fanneløb Giskeødegård, Anna Karlberg, Unn-Merete Fagerli, Live Eikenes
This PET/MRI study compared contrast-enhanced MRI, 18F-FACBC-, and 18F-FDG-PET in the detection of primary central nervous system lymphomas (PCNSL) in patients before and after high-dose methotrexate chemotherapy. Three immunocompetent PCNSL patients with diffuse large B-cell lymphoma received dynamic 18F-FACBC- and 18F-FDG-PET/MRI at baseline and response assessment. Lesion detection was defined by
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Diagnostic value of FDG PET-CT in differentiating lung adenocarcinoma from squamous cell carcinoma Eur. J. Hybrid Imaging Pub Date : 2024-01-30 Adem Maman, Sadık Çiğdem, İdris Kaya, Rabia Demirtaş, Onur Ceylan, Sevilay Özmen
Lung cancer is the leading cause of cancer-related deaths worldwide. The combination of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) and computed tomography (CT) has a major impact on the diagnosis, staging, treatment planning and follow-up of lung cancer patients. The maximum standardized uptake value (SUVmax) is an easily performed and most widely used semi-quantitative
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Exploring the applicability of a lesion segmentation method on [18F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma Eur. J. Hybrid Imaging Pub Date : 2023-12-25 Germán Pitarch, Yamila Rotstein Habarnau, Roxana Chirico, Brenda Konowalik, Amalia Pérez, Alejandro Valda, María Bastianello
The determination of the total metabolic tumour volume based on [18F]fluorothymidine ([18F]FLT) PET/CT images in diffuse large B-cell lymphoma has a potential clinical value for detecting early relapse in this type of heterogeneous lymphoproliferative tumours. Tumour segmentation is a key step in this process. For this purpose, our objective was to determine a segmentation threshold of [18F]FLT PET/CT
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Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients Eur. J. Hybrid Imaging Pub Date : 2023-12-18 Peerapon Kiatkittikul, Supanida Mayurasakorn, Chetsadaporn Promteangtrong, Anchisa Kunawudhi, Dheeratama Siripongsatian, Natdanai Hirata, Attapon Jantarato, Natphimol Boonkawin, Sukanya Yaset, Pattanapong Kongsakorn, Warunya Phewnual, Chanisa Chotipanich
To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed
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Comparative analysis of two timepoints on [18F]FAPI-42 PET/CT in various cancers Eur. J. Hybrid Imaging Pub Date : 2023-12-11 Xingyu Mu, Biyun Mo, Jie Qin, Zuguo Li, Weixia Chong, Yulong Zeng, Lu Lu, Lei Zhang, Wei Fu
This study aimed to assess the biodistribution, detection rate, and uptake of the [18F]FAPI-42 at two distinct time intervals. This prospective study enrolled 60 consecutive patients (median age 59; range 35–74) referred to [18F]FAPI-42 PET/CT. [18F]FAPI-42 PET/CT was performed early and late timepoint after tracer injection for staging or restaging. Positive lesions specified for anatomic locations
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Added value of regional 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in malignant ascites with unknown primary origin Eur. J. Hybrid Imaging Pub Date : 2023-12-04 Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu
Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in diagnosing malignant ascites patients. The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic
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Signet cell rectal carcinoma with prostatic involvement detected by FAPI-04 PET-MRI fusion Eur. J. Hybrid Imaging Pub Date : 2023-12-01 K. Arun Prashanth, Deepti Jain, R. Manikandan, Suman Kalyan, Vimalraj Velayutham, R. Surendran
A 60-year-old male patient diagnosed with mucinous adenocarcinoma of lower third of rectum underwent abdominoperineal resection and permanent colostomy followed by adjuvant chemotherapy. Response evaluation with F-18 FDG PET-CT showed a complete metabolic response. After 6 months, CEA levels started increasing and clinically a recurrence was suspected. A restaging FDG PET-CT showed no obvious malignant
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[18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging Eur. J. Hybrid Imaging Pub Date : 2023-11-24 Kristian Valind, David Minarik, Sabine Garpered, Eva Persson, Jonas Jögi, Elin Trägårdh
Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging
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Association between body mass index (BMI) and [123I]Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon emission computed tomography–computed tomography (SPECT-CT) Eur. J. Hybrid Imaging Pub Date : 2023-11-20 Puja Parekh, Patrick Begley, Maryam Jessop, Mark Aplin, Elena Missir, Helena McMeekin, Gosia Raczek, Nitasha Singh, Sabina Dizdarevic
[123I]Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). Both neurotransmitters are considered to contribute to body weight regulation. This study assesses the association between body mass index (BMI) and DaTSCAN availability in brain. Scans from 74 consecutive patients who had undergone DaTSCAN single-photon
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Accuracy of combined multi-parametric MRI and PSMA PET-CT in diagnosing localized prostate cancer: newer horizons for a biopsy-free pathway Eur. J. Hybrid Imaging Pub Date : 2023-11-10 Aditya Prakash Sharma, Rajender Kumar, Rohit Chauhan, Shiraz Akif Ziauddin, Shanky Singh, Harmandeep Singh, Sudheer Kumar Devana, Ujjwal Gorsi, Girdhar Singh Bora, Ravimohan S. Mavuduru, Santosh Kumar, Uttam K. Mete, Bhagwant Rai Mittal
Prostate-specific antigen (PSA) is a reliable biomarker for identification of prostate cancer, although a biopsy is still the gold standard for detecting prostate cancer. Similar to higher PIRADS lesions on MRI, the maximal standard uptake value (SUV max) on PSMA PET is linked to a higher likelihood of prostate cancer. Can an mpMRI in conjunction with PSMA PET Scan accurately predict prostate cancer
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Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study Eur. J. Hybrid Imaging Pub Date : 2023-11-06 Bianca Mazini, Matthieu Dietz, Bénédicte Maréchal, Ricardo Corredor-Jerez, John O. Prior, Vincent Dunet
Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and brain SVD by using quantitative 82Rb cardiac PET/CT and brain MRI. In our population of 370 patients, 176 had normal myocardial perfusion, 38 had pure cardiac
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The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients Eur. J. Hybrid Imaging Pub Date : 2023-10-16 Magdi A. Ali, Eman El-Abd, Mohamed Morsi, Mohamed M. El Safwany, Mohamed Z. El-Sayed
Hepatic steatosis is the most common chronic hepatic disease. Imaging diagnosis of hepatic steatosis has been evaluated as an alternative to invasive histological diagnosis. The study aimed to assess the effect of hepatic steatosis on Flourine-18 fluorodeoxyglucose (18F-FDG) uptakes in cancer patients. Blood samples were collected from 50 cancer patients and analyzed to calculate fatty liver index
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Associations of quantitative whole-body PSMA-PET metrics with PSA progression status under long-term androgen deprivation therapy in prostate cancer patients: a retrospective single-center study Eur. J. Hybrid Imaging Pub Date : 2023-10-02 Vishnu Murthy, Emmanuel Appiah-Kubi, Kathleen Nguyen, Pan Thin, Masatoshi Hotta, John Shen, Alexandra Drakaki, Matthew Rettig, Andrei Gafita, Jeremie Calais, Ida Sonni
To evaluate whether quantitative whole-body (WB) PSMA-PET metrics under long-term androgen deprivation therapy (ADT) and/or androgen receptor signaling inhibitors (ARSi) are associated with PSA progression. Patients who underwent at least 2 68Ga-PSMA-11 PET/CT scans between October 2016 and April 2021 (n = 372) and started a new line of ADT ± ARSi between PET1 and PET2 were retrospectively screened
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Incorporation of CAD (computer-aided detection) with thin-slice lung CT in routine 18F-FDG PET/CT imaging read-out protocol for detection of lung nodules Eur. J. Hybrid Imaging Pub Date : 2023-09-18 Ujwal Bhure, Matthäus Cieciera, Dirk Lehnick, Maria del Sol Pérez Lago, Hannes Grünig, Thiago Lima, Justus E. Roos, Klaus Strobel
To evaluate the detection rate and performance of 18F-FDG PET alone (PET), the combination of PET and low-dose thick-slice CT (PET/lCT), PET and diagnostic thin-slice CT (PET/dCT), and additional computer-aided detection (PET/dCT/CAD) for lung nodules (LN)/metastases in tumor patients. Along with this, assessment of inter-reader agreement and time requirement for different techniques were evaluated
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Lung CT stabilization with high-frequency non-invasive ventilation (HF-NIV) and breath-hold (BH) in lung nodule assessment by PET/CT Eur. J. Hybrid Imaging Pub Date : 2023-09-04 Mario Jreige, Emeline Darçot, Alban Lovis, Julien Simons, Marie Nicod-Lalonde, Niklaus Schaefer, Flore Buela, Olivier Long, Catherine Beigelman-Aubry, John O. Prior
To evaluate the effect of lung stabilization using high-frequency non-invasive ventilation (HF-NIV) and breath-hold (BH) techniques on lung nodule detection and texture assessment in PET/CT compared to a free-breathing (FB) standard lung CT acquisition in PET/CT. Six patients aged 65 ± 7 years, addressed for initial assessment of at least one suspicious lung nodule with 18F-FDG PET/CT, underwent three
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F-18 FDG PET/CT in staging and response assessment of primary cutaneous diffuse large B-cell lymphoma (leg type) Eur. J. Hybrid Imaging Pub Date : 2023-08-22 Deepanksha Datta, Rakesh Ramprakash Pandey, Rajesh Kumar, Rashim Sharma, Deepak Vedant
Primary cutaneous Diffuse Large B-Cell Lymphoma-leg type (PCDLBCL-LT) is a rare subtype of cutaneous lymphomas, with high frequency of extra-cutaneous relapse and poor prognosis. We report a case of 70-year-old lady who was diagnosed with PCDLBCL-LT on biopsy and underwent a baseline F-18 FDG PET/CT, followed by interim and post-treatment PET/CTs. With this case report, we highlight the findings of
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AI-based quantification of whole-body tumour burden on somatostatin receptor PET/CT Eur. J. Hybrid Imaging Pub Date : 2023-08-07 Anni Gålne, Olof Enqvist, Anna Sundlöv, Kristian Valind, David Minarik, Elin Trägårdh
Segmenting the whole-body somatostatin receptor-expressing tumour volume (SRETVwb) on positron emission tomography/computed tomography (PET/CT) images is highly time-consuming but has shown value as an independent prognostic factor for survival. An automatic method to measure SRETVwb could improve disease status assessment and provide a tool for prognostication. This study aimed to develop an artificial
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FDG-PET/CT for lymph node staging prior to radical cystectomy Eur. J. Hybrid Imaging Pub Date : 2023-07-24 Vilhelm Pihl, Maria Markus, Johan Abrahamsson, Mats Bläckberg, Oskar Hagberg, Petter Kollberg, Athanasios Simoulis, Elin Trägårdh, Fredrik Liedberg
18F-Fluorodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC). Our aim was to assess the accuracy of FDG-PET/CT for lymph node staging ascertained at the multidisciplinary tumour board compared to lymph node status in the surgical lymphadenectomy specimen
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Clinical impact of 99mTc-MAA SPECT/CT-based personalized predictive dosimetry in selective internal radiotherapy: a real-life single-center experience in unresectable HCC patients Eur. J. Hybrid Imaging Pub Date : 2023-07-07 Ana-Maria Bucalau, Benoît Collette, Illario Tancredi, Michael Vouche, Martina Pezzullo, Jason Bouziotis, Rodrigo Moreno-Reyes, Nicola Trotta, Hugo Levillain, Jean Luc Van Laethem, Gontran Verset
Recent data demonstrated that personalized dosimetry-based selective internal radiotherapy (SIRT) is associated with better outcome for unresectable hepatocellular carcinoma (HCC). We aim to evaluate the contribution of personalized predictive dosimetry (performed with Simplicity90® software) in our population of HCC patients by comparing them to our historical cohort whose activity was determined
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Volume of the proximal half of the thoracic aorta is the most comprehensive FDG-PET/CT indicator of arterial aging throughout adulthood Eur. J. Hybrid Imaging Pub Date : 2023-06-28 Moira Hurstel, Laure Joly, Laetitia Imbert, Gaetan Zimmermann, Véronique Roch, Pauline Schoepfer, Zohra Lamiral, Paolo Salvi, Athanase Benetos, Antoine Verger, Pierre-Yves Marie
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) features of the proximal and more elastic half of the thoracic aorta are known to correlate with aorta stiffness in older populations. This prospective study aimed to analyze the changes in these FDG-PET/CT features between young, middle-aged, and older adults, and investigate associations with arterial stiffness
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Widespread presentation of brown tumors mimicking multiple myeloma Eur. J. Hybrid Imaging Pub Date : 2023-06-08 Julien Duyck, Katrien Spincemaille, Jan Verfaillie, Caressa Meert, Kristoff Muylle
Brown tumors or osteitis fibrosa cystica has become a rare presentation of primary hyperparathyroidism in up-to-date clinical practice. Here, we describe a case of longstanding untreated hyperparathyroidism presenting itself with brown tumors in a 65-year-old patient. During the diagnostic work-up of this patient, bone SPECT/CT and 18F-FDG-PET/CT revealed multiple widespread osteolytic lesions. Differentiating
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PET/CT imaging 2 h after injection of [18F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h Eur. J. Hybrid Imaging Pub Date : 2023-05-01 Erland Hvittfeldt, Ulrika Bitzén, David Minarik, Jenny Oddstig, Berit Olsson, Elin Trägårdh
[18F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90–120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether imaging after 1 h and 2 h leads to a different number of detected lesions, with a specific focus on lesions that might lead
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Is there more than meets the eye in PSMA imaging in prostate cancer with PET/MRI? Looking closer at uptake time, correlation with PSA and Gleason score Eur. J. Hybrid Imaging Pub Date : 2023-04-17 Borjana Bogdanovic, Esteban L. Solari, Alberto Villagran Asiares, Sandra van Marwick, Sylvia Schachoff, Matthias Eiber, Wolfgang A. Weber, Stephan G. Nekolla
In patients with increasing PSA and suspicion for prostate cancer, but previous negative biopsies, PET/MRI is used to test for tumours and target potential following biopsy. We aimed to determine different PSMA PET timing effects on signal kinetics and test its correlation with the patients’ PSA and Gleason scores (GS). A total of 100 patients were examined for 900 s using PET/MRI approximately 1–2 h
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Quantitative assessment of PSMA PET response to therapy in castration-sensitive prostate cancer using an automated imaging platform for disease identification and measurement Eur. J. Hybrid Imaging Pub Date : 2023-04-03 Sai Duriseti, Gholam Berenji, Sonny Tsai, Matthew Rettig, Nicholas G. Nickols
Prostate cancer treatment response may be automatically quantified using a molecular imaging analysis platform targeting prostate-specific membrane antigen (PSMA). A retrospective analysis of patients with castration-sensitive prostate cancer who underwent PSMA-targeted molecular imaging prior to and 3 months or more after treatment was conducted. Disease burden was analyzed with aPROMISE, an artificial
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Now you see me: lights on Merkel Cell Carcinoma Eur. J. Hybrid Imaging Pub Date : 2023-03-20 Cristiano Pini, Giovanni Matassa, Fabrizia Gelardi, Lidija Antunovic
Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [18F]FDG PET/CT is more widespread and its prognostic role is well established. We present the case of an MCC patient suspected recurrence who
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Prognostic analysis of curatively resected pancreatic cancer using harmonized positron emission tomography radiomic features Eur. J. Hybrid Imaging Pub Date : 2023-03-06 Masao Watanabe, Ryo Ashida, Chisato Miyakoshi, Shigeki Arizono, Tsuyoshi Suga, Shotaro Kanao, Koji Kitamura, Takahisa Ogawa, Reiichi Ishikura
Texture features reflecting tumour heterogeneity enable us to investigate prognostic factors. The R package ComBat can harmonize the quantitative texture features among several positron emission tomography (PET) scanners. We aimed to identify prognostic factors among harmonized PET radiomic features and clinical information from pancreatic cancer patients who underwent curative surgery. Fifty-eight
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Quantitative Iodine-123 single-photon emission computed tomography/computed tomography for Iodine-131 therapy of an autonomously functioning thyroid nodule Eur. J. Hybrid Imaging Pub Date : 2023-02-20 Won Woo Lee, Yoo Sung Song, Young So
Autonomously functioning thyroid nodules (AFTNs) are treated with iodine-131 (I-131) therapy, which increases the risk of permanent hypothyroidism; however, the risk can be reduced by separately estimating the accumulated activity for the AFTN and extranodular thyroid tissue (ETT). A quantitative I-123 single-photon emission computed tomography (SPECT)/CT (5 mCi) was performed in one patient with unilateral
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Comparison of integrin αvβ3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers Eur. J. Hybrid Imaging Pub Date : 2023-02-01 Matthieu Dietz, Vincent Dunet, Styliani Mantziari, Anastasia Pomoni, Ricardo Dias Correia, Nathalie Testart Dardel, Sarah Boughdad, Marie Nicod Lalonde, Giorgio Treglia, Markus Schafer, Niklaus Schaefer, John O. Prior
The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68Ga-NODAGA-RGD PET/CT with that of 18F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination. Ten 68Ga-NODAGA-RGD and ten 18F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40–69
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18F-JK-PSMA-7 PET/CT for staging intermediate- or high-risk prostate cancer patients before radical prostatectomy: a pilot study Eur. J. Hybrid Imaging Pub Date : 2023-01-23 Irina Vierasu, Gaetan Van Simaeys, Nicola Trotta, Simon Lacroix, Guy Bormans, Simone Albisinni, Thierry Quackels, Thierry Roumeguère, Serge Goldman
Positron emission tomography/computed tomography (PET/CT) using radiotracers that bind to the prostate-specific membrane antigen (PSMA) is mainly used in biochemical recurring prostate cancer. The aim of our study was to assess the usefulness of 18F-JK-PSMA-7 PET/CT for local and nodal staging in patients with intermediate- and high-risk prostate cancer (PCa) prior to radical prostatectomy, as compared
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Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies Eur. J. Hybrid Imaging Pub Date : 2023-01-13 Melki, Saifeddine, Moulinet, Thomas, Verger, Antoine, Marie, Pierre-Yves, Imbert, Laetitia, Bahloul, Achraf
Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. 18F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized
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Volumetric parameters of the primary tumor and whole-body tumor burden derived from baseline 18F-FDG PET/CT can predict overall survival in non-small cell lung cancer patients: initial results from a single institution Eur. J. Hybrid Imaging Pub Date : 2022-12-28 Mahmoud, Hemat A., Oteify, Walaa, Elkhayat, Hussein, Zaher, Ahmed M., Mohran, Taha Zaki, Mekkawy, Nesreen
Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are volumetric parameters derived from 18F-FDG PET/CT, suggested to have a prognostic value in cancer patients. Our study aimed to test whether these volumetric parameters of the primary tumor and whole-body tumor burden (WBTB) can predict overall survival (OS) in non-small cell lung cancer (NSCLC) patients. Thirty biopsy-proven NSCLC patients
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Regional differences in the reduction in cerebral FDG uptake induced by the ketogenic diet Eur. J. Hybrid Imaging Pub Date : 2022-12-15 Bennett, O. A., Ramsay, S. C., Malacova, E., Bourgeat, P., Goodman, S. J., Dunn, C. J., Robinson, B. M., Lee, K., Pattison, D. A.
The postulated benefits of the ketogenic diet in the management of multiple medical conditions have seen more patients who are in therapeutic ketosis attending 18F-FDG PET scans. This study aimed to investigate the effect of ketosis on cerebral glucose metabolism in a clinical PET scanning environment using 18F-FDG uptake as a surrogate marker. A retrospective audit was conducted of the brain 18F-FDG
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Lymphopenia during 177Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report Eur. J. Hybrid Imaging Pub Date : 2022-12-13 Boughdad, Sarah, Da Mota, Michael, Mendes De Carvalho, Mélanie, Firsova, Maria, Prior, John O., Schaefer, Niklaus
We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of 177Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development
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Hyperfunctioning parathyroid gland and skeletal involvement on [18F]fluorocholine PET/CT: one look with two views Eur. J. Hybrid Imaging Pub Date : 2022-12-12 Nappi, Carmela, Piscopo, Leandra, Klain, Michele, Mainolfi, Ciro Gabriele, Vergara, Emilia, Adamo, Daniela, Mignogna, Michele Davide, Cuocolo, Alberto
Hyperparathyroidism is an endocrine disorder that may be associated with other metabolic diseases. Non-invasive imaging techniques including [99mTc]Tc-sestamibi single-photon emission computed tomography (SPECT) and [18F]fluorocholine positron emission tomography (PET)/computed tomography (CT) play a key role on management of patients with hyperparathyroidism. We report for the first time a case of
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Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT Eur. J. Hybrid Imaging Pub Date : 2022-12-05 Isohashi, Kayako, Kanai, Yasukazu, Aihara, Teruhito, Hu, Naonori, Fukushima, Kentaro, Baba, Ichiro, Hirokawa, Fumitoshi, Kakino, Ryo, Komori, Tsuyoshi, Nihei, Keiji, Hatazawa, Jun, Ono, Koji
The goal of the study was to evaluate the diagnostic ability of 18F-FBPA PET/CT for malignant tumors. Findings from 18F-FBPA and 18F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or benign lesions. A total of 82 patients (45 males, 37 females; median age, 63 years; age range, 20–89 years) with various types of malignant tumors or benign lesions, such as inflammation
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Diagnostic performance of quantitative Ga-SPECT/CT for patients with lower-limb osteomyelitis Eur. J. Hybrid Imaging Pub Date : 2022-12-01 Nishikawa, Yoshito, Fukushima, Yoshimitsu, Kirinoki, Sonoko, Takagi, Gen, Suda, Masaya, Maki, Toshio, Kumita, Shinichiro
Patients with lower-limb osteomyelitis (LLOM) may experience major adverse events, such as lower-leg amputations or death; therefore, early diagnosis and risk stratification are essential to improve outcomes. Ga-scintigraphy is commonly used for diagnosing inflammatory diseases. Although the diagnostic performance of planar and SPECT imaging for localized lesions is limited, SPECT/CT, which simultaneously
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Rare sites of metastases in patients with differentiated thyroid carcinoma and added value of SPECT/CT over planar whole body radioactive iodine scan Eur. J. Hybrid Imaging Pub Date : 2022-11-28 Bashank, Nahla, Farghaly, Hussein, Hassanein, Sara, Abdel-Tawab, Mohamed, Wahman, Mohamed, Mahmoud, Hemat
Being aware of the unusual or rare location of thyroid metastases helps in early diagnosis and proper patient management. Rare metastases (RM) can be missed resulting in diagnostic pitfalls and delayed treatment. The use of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging in the follow-up of differentiated thyroid cancer (DTC) patients provides precise anatomical localization
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Evaluation of lung perfusion by using lung perfusion SPECT and lung CT with breathing synchronization software Eur. J. Hybrid Imaging Pub Date : 2022-11-25 Hashimoto, Hidenobu, Soma, Tsutomu, Mizumura, Sunao, Kokubo, Tadashi, Nakanishi, Rine, Ikeda, Takanori
Lung perfusion using 99mTc-macroaggregated albumin single-photon emission computed tomography (SPECT) and lung computed tomography (CT) is a useful modality for identifying patients with pulmonary artery embolism. However, conformity between SPECT and CT at the bottom of the lung is generally low. This study aims to investigate the progression of conformity between lung perfusion SPECT and lung CT
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Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study Eur. J. Hybrid Imaging Pub Date : 2022-11-21 Lia, Erica Negrini, Papassidero, Priscila Colavite, Coelho, Eduardo Barbosa, Dach, Fabíola, Alexandre-Santos, Leonardo, Trevisan, Ana Carolina, Santos, Lucas Emmanuel Lopes e, Silvah, Jose Henrique, Lanchote, Vera Lúcia, Pasqua, Oscar Della, Wichert-Ana, Lauro
Recent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [99mTc]Tc-ECD brain SPECT and correlated
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Bone scintigraphy outperformed anatomic images in frostbite injuries: a case report Eur. J. Hybrid Imaging Pub Date : 2022-11-10 Ronchi, Brunela, Peña, Gustavo Agustin, Carla, Albertti
Frostbite is a localized cold thermal injury, as a result of tissue exposure to temperatures below freezing point for a prolonged period of time. The spectrum of injury is broad; thus, frostbite injuries may have deleterious effects with the possibility of losing part or whole extremities. We aim to present the case of a 38-year-old male patient evaluated with multiphase technetium-99m-methylene diphosphonate
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Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty Eur. J. Hybrid Imaging Pub Date : 2022-11-07 Bourdon, Caleigh E., Koudys, Zachary J., Lanting, Brent A., Appleton, C. Thomas, Thiessen, Jonathan D., Teeter, Matthew G.
Positron emission tomography (PET) in combination with magnetic resonance imaging (MRI) could allow inflammatory complications near total knee arthroplasty (TKA) to be studied early in their development. However, attenuation of the PET signal by the metal TKA implants imparts substantial error into measurements of tracer activity, and conventional MR-based attenuation correction (AC) methods have large
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PET/MR: primary inferior vena cava leiomyosarcoma Eur. J. Hybrid Imaging Pub Date : 2022-11-01 Ronchi, Brunela, Peña, Gustavo Agustin, Sacchi, Carlos
Positron emission tomography (PET) combined with a magnetic resonance (MR) scanner (PET/MR) with 18F-fluorodeoxyglucose (FDG) tracer is being used in quite a few nuclear medicine centers. The aim of this study is to illustrate two uncommon cases of primary inferior vena cava leiomyosarcoma which were formerly evaluated with anatomical images such as computed tomography and ultrasound. These techniques
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Reproducibility of lung cancer radiomics features extracted from data-driven respiratory gating and free-breathing flow imaging in [18F]-FDG PET/CT Eur. J. Hybrid Imaging Pub Date : 2022-10-30 Faist, Daphné, Jreige, Mario, Oreiller, Valentin, Nicod Lalonde, Marie, Schaefer, Niklaus, Depeursinge, Adrien, Prior, John O.
Quality and reproducibility of radiomics studies are essential requirements for the standardisation of radiomics models. As recent data-driven respiratory gating (DDG) [18F]-FDG has shown superior diagnostic performance in lung cancer, we evaluated the impact of DDG on the reproducibility of radiomics features derived from [18F]-FDG PET/CT in comparison to free-breathing flow (FB) imaging. Twenty four
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Necrotizing granulomatous inflammation mimicking skeletal metastasis: a possible differential diagnosis Eur. J. Hybrid Imaging Pub Date : 2022-10-28 Datta, Deepanksha, Ravichandran, T., Kumar, Rajesh, Sharma, Rashim, Vedant, Deepak
Tuberculosis is an endemic disease in India for decades, and its coexistence in the patients with malignancy cannot be ignored. The non-specific uptake of 2-deoxy-2-[fluorine-18] fluoro-d-glucose in active infection and malignancy can affect the diagnosis and management of patients. However, characteristic anatomical features of the lesion aid not only in its localization but also in diagnosis. We
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Uncommon disseminated muscular metastasis from suspected lung adenocarcinoma in a 18F-FDG PET/CT study Eur. J. Hybrid Imaging Pub Date : 2022-10-24 Pacella, S.
Skeletal muscle metastasis from lung cancer is a rare phenomenon. In this case report, FDG PET/CT imaging detected unexpected metastatic spread in skeletal muscles from lung cancer.
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Variations induced by body weight and background lesion normalization in standardized uptake value estimated by F18-FDG PET/CT Eur. J. Hybrid Imaging Pub Date : 2022-10-13 Badawe, Eman M., Abdel Gawad, Hesham, El-Nagdy, Mohamed S., Khalil, Magdy M.
This work aims to study the impact of different SUV variants in terms of mean and maximum measures as well as various normalization methods with respect to body weight, body mass index, body surface area, and lean body mass in patients with lymphoma. Sixty-nine patients (34 male–35 female) were retrospectively selected. All patients had undergone F18-FDG PET/CT using the standard imaging protocol.
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Cross-sectional evaluation of FGD-avid polyostotic fibrous dysplasia: MRI, CT and PET/MRI findings Eur. J. Hybrid Imaging Pub Date : 2022-10-03 Pozzessere, Chiara, Cicone, Francesco, Barberio, Paolo, Papa, Annalisa, Coppolino, Giuseppe, Biagini, Roberto, Cascini, Giuseppe Lucio
A 42-year-old male with left hip pain was diagnosed of several right femoral and tibial bone tumours. All lesions were osteolytic with sclerotic margins. The symptomatic lesion in the proximal femur also showed bone expansion and focal cortical thinning. Whole-body [18F]-fluorodeoxyglucose (FDG) PET/CT and segmental PET/MRI of the left hip and femur were performed for metabolic characterization of
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Retention index of FDG-PET/CT SUVmax of the primary tumor in non-small cell lung cancer as a predictor of lymph node metastasis: a retrospective study Eur. J. Hybrid Imaging Pub Date : 2022-09-27 Ema, Toshinari, Kojima, Hideaki, Mizuno, Shinji, Hirai, Tatsuo, Oka, Mikako, Neyatani, Hiroshi, Funai, Kazuhito, Shiiya, Norihiko
Accurate staging of non-small cell lung cancer is key in treatment planning and prediction of prognosis. We investigated the correlation between the maximum standardized uptake value (SUVmax) retention index (RI) of the primary tumor and lymph node metastasis in non-small cell lung carcinoma. We also evaluated the tendencies according to the histological types. We retrospectively evaluated 218 non-small
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Foreign body-type giant cell reaction with extensive granulation tissue and intense inflammation after chemotherapy mimicking residual lymphoma on FDG PET Eur. J. Hybrid Imaging Pub Date : 2022-09-15 Kazi, Sakib, Raptis, Stavros, Abbaspour, Farzad, Zeng, Wanzhen
Foreign body-type giant cell reaction is typically a biological and immunological reaction to the presence of foreign bodies such as catheters, parasites or biomaterials with a collection of fused macrophages (giant cell). We reported an unusual case of [18F]FDG PET findings in diffuse large B cell lymphoma in the urinary bladder following incomplete resection and chemotherapy. As the restaging [18F]FDG
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A role for artificial intelligence in molecular imaging of infection and inflammation Eur. J. Hybrid Imaging Pub Date : 2022-09-01 Schwenck, Johannes, Kneilling, Manfred, Riksen, Niels P., la Fougère, Christian, Mulder, Douwe J., Slart, Riemer J. H. A., Aarntzen, Erik H. J. G.
The detection of occult infections and low-grade inflammation in clinical practice remains challenging and much depending on readers’ expertise. Although molecular imaging, like [18F]FDG PET or radiolabeled leukocyte scintigraphy, offers quantitative and reproducible whole body data on inflammatory responses its interpretation is limited to visual analysis. This often leads to delayed diagnosis and
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Early acquisition of [18F]FDOPA PET/CT imaging in patients with recurrent or residual medullary thyroid cancer is safe—and slightly better! Eur. J. Hybrid Imaging Pub Date : 2022-08-25 Kjærulff, Mette Louise Gram, Dias, André H., Iversen, Peter, Gormsen, Lars Christian, Hjorthaug, Karin
The aim of this study was to compare early (15 min) and late (60 min) [18F]FDOPA PET/CT acquisition times in the detection of recurrence/residual disease in medullary thyroid cancer (MTC) patients. Thirty-two dual-phase [18F]FDOPA PET scans were retrospectively reviewed. Scan indications were (1) suspected recurrence of MTC, (2) treatment monitoring, or (3) restaging. In four scans, no final verification
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Combined modality PET/MR for the detection of severe large vessel vasculitis Eur. J. Hybrid Imaging Pub Date : 2022-08-15 Cerne, John W., Liu, Sophia, Umair, Muhammad, Pathrose, Ashitha, Moore, Jackson E., Allen, Bradley D., Markl, Michael, Carr, James C., Savas, Hatice, Wilsbacher, Lisa, Avery, Ryan
Large vessel vasculitis (LVV) can be characterized based on symptom severity, and this characterization helps clinicians decide upon treatment approach. Our aim was to compare the imaging findings of combined modality positron emission tomography/magnetic resonance (PET/MR) and inflammatory markers between severe and non-severe LVV. A retrospective query was performed to identify all patients with
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Diagnostic value of hybrid FDG-PET/MR imaging of chronic osteomyelitis Eur. J. Hybrid Imaging Pub Date : 2022-08-01 Hulsen, Dennis Jan Willem, Mitea, Cristina, Arts, Jacobus J., Loeffen, Daan, Geurts, Jan
Magnetic resonance imaging (MRI) and 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG) Positron Emission Tomography, paired with Computed Tomography (PET/CT) are commonly used modalities in the complicated diagnostic work-up of osteomyelitis. PET/MRI is a relatively novel hybrid modality with suggested applications in bone infection imaging, based on expert opinion and previous qualitative research. 18F-FDG
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68Ga-PSMA-11 PET/MRI versus multiparametric MRI in men referred for prostate biopsy: primary tumour localization and interreader agreement Eur. J. Hybrid Imaging Pub Date : 2022-07-18 Ferraro, Daniela A., Hötker, Andreas M., Becker, Anton S., Mebert, Iliana, Laudicella, Riccardo, Baltensperger, Anka, Rupp, Niels J., Rueschoff, Jan H., Müller, Julian, Mortezavi, Ashkan, Sapienza, Marcelo T., Eberli, Daniel, Donati, Olivio F., Burger, Irene A.
Magnetic resonance imaging (MRI) is recommended by the European Urology Association guidelines as the standard modality for imaging-guided biopsy. Recently positron emission tomography with prostate-specific membrane antigen (PSMA PET) has shown promising results as a tool for this purpose. The aim of this study was to compare the accuracy of positron emission tomography with prostate-specific membrane
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Gastrointestinal neuroendocrine tumor with discordant metastatic disease on 111In-pentetreotide SPECT/CT, 18F-DOPA PET/CT and 68Ga-HA-DOTATATE PET/CT Eur. J. Hybrid Imaging Pub Date : 2022-07-04 Resch, Katrin, Hung, Ryan, Abele, Jonathan
A 62-year-old man with resected, pathology-proven small bowel neuroendocrine tumor underwent 111In-pentetreotide SPECT/CT, 18F-DOPA PET/CT and 68Ga-HA-DOTATATE PET/CT to assess metastatic disease. The 111In-pentetreotide SPECT/CT scan showed no metastatic disease. Both 18F-DOPA and 68Ga-HA-DOTATATE PET/CT showed hepatic and peritoneal metastatic disease. However, the burden of 18F-DOPA-avid metastatic
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Comparison of [18F]DOPA and [68Ga]DOTA-TOC as a PET imaging tracer before peptide receptor radionuclide therapy Eur. J. Hybrid Imaging Pub Date : 2022-06-15 Veenstra, Emile B., Brouwers, Adrienne H., de Groot, Derk Jan A., Hofland, Johannes, Walenkamp, Annemiek M. E., Brabander, Tessa, Zandee, Wouter T., Noordzij, Walter
In treatment of neuroendocrine neoplasms (NENs), confirmation of somatostatin receptor expression with 68Ga-DOTA somatostatin analogues is mandatory to determine eligibility for peptide receptor radionuclide therapy (PRRT). [18F]DOPA can detect additional lesions compared to [68Ga]DOTA-TOC. The aim of this study was to explore differences in tumour detection of both tracers and their relevance for