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Prevalence and correlates of ICD‐11 prolonged grief disorder among adults living in Ukraine during the war with Russia Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-03-16 Enya Redican, Philip Hyland, Mark Shevlin, Dmytro Martsenkovskyi, Thanos Karatzias, Menachem Ben‐Ezra
BackgroundAlthough high rates of bereavement are evident in war‐affected populations, no study has investigated the prevalence and correlates of probable ICD‐11 prolonged grief disorder (PGD) under these circumstances.MethodsParticipants were 2050 adults who participated in a nationwide survey exploring the effects of the Ukraine‐Russia war on the daily lives and mental health of Ukrainian people.ResultsOf
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Can generative artificial intelligence facilitate illustration of‐ and communication regarding hallucinations and delusions? Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-03-16 Søren Dinesen Østergaard
In the context of artificial intelligence (AI), the term “hallucinations” is used to refer to false responses generated by conversational agents/chatbots or other generative AI tools (artificial intelligence/machine learning models capable of generating content such as text, speech, images and video).1, 2 This metaphor is unfortunate as it is both imprecise and, due to its clear negative connotation
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Decreased oxytocin levels related to social cognition impairment in borderline personality disorder Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-03-13 Alejandra Galvez‐Merlin, José M. López‐Villatoro, Pilar de la Higuera‐González, Alejandro de la Torre‐Luque, Karina McDowell, Marina Díaz‐Marsá, Juan C. Leza, José L. Carrasco
IntroductionDysfunctions in the oxytocin system have been reported in patients with borderline personality disorder (BPD). Deficits could be related to interpersonal hypersensitivity, which has been previously associated with failures in social cognition (SC) in this disorder, especially in Theory of Mind (ToM) skills. The aim of this work is to study the links between the oxytocin system and SC impairments
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Psychotherapy duration and work disability: A prospective Finnish register study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-03-04 Sanna Selinheimo, Kia Gluschkoff, Johanna Kausto, Jarno Turunen, Ari Väänänen
IntroductionThe influence of psychotherapy duration on common mental disorder (CMD) outcomes remains a topic of ongoing debate. Whereas most research has focused on CMD symptom change, the evidence on the psychotherapy duration of subsequent CMD‐related work disability and the change in psychotropic drug purchases is scarce.MethodsWe used a register‐based cohort representing 33% of the Finnish population
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Clarifying the relationship between physical injuries and risk for suicide attempt in a Swedish national sample Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-28 Mallory Stephenson, Henrik Ohlsson, Séverine Lannoy, Jan Sundquist, Kristina Sundquist, Alexis C. Edwards
IntroductionThe Interpersonal‐Psychological Theory of Suicide proposes that capability for suicide is acquired through exposure to painful and provocative events (PPEs). Although there is robust evidence for a positive association between aggregate measures of PPEs and risk for suicidal behavior, little is known about the contributions of physical injuries. The present study investigated the relationship
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Inpatient admissions and mortality of anorexia nervosa patients according to their preceding psychiatric and somatic diagnoses Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-26 Natalie C. Momen, Jindong Ding Petersen, Zeynep Yilmaz, Birgitte D. Semark, Liselotte Vogdrup Petersen
Anorexia nervosa (AN) is associated with increased risk of mortality, but little is known about the risk of inpatient admissions and mortality outcomes in individuals with diagnoses of both AN and other psychiatric and somatic conditions. We aimed to investigate the inpatient admissions and mortality among people with AN and other diagnosed conditions using Danish national registers.
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Impact of a private sector residential early parenting program on clinically significant postnatal depressive symptoms experienced by women: Audit of routinely collected data Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-26 Jane Fisher, Karin Stanzel, Hau Nguyen, Patsy Thean, Danielle French, Sally Popplestone, Thach Tran
IntroductionEarly parenting services in Australia offer brief structured residential programs to address moderate to severe non‐psychotic mental health problems among women and unsettled infant/toddler behaviours. The aims were to (1) estimate the immediate and medium‐term impact of a five‐night psychoeducational residential early parenting program on postpartum depressive symptoms and (2) identify
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Antipsychotic agents in anxiety disorders: An umbrella review Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-21 Amir Garakani, Frank D. Buono, Mona Salehi, Melissa C. Funaro, Anna Klimowicz, Harshit Sharma, Clara G. F. Faria, Kaitlyn Larkin, Rafael C. Freire
Although not approved for the treatment of anxiety disorders (except trifluoperazine) there is ongoing off-label, unapproved use of first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) for anxiety disorders. There have been systematic reviews and meta-analyses on the use of antipsychotics in anxiety disorders, most of which focused on SGAs.
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Obsessive-compulsive disorder: Taking the long view Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-21 Robert Stewart, Lieuwe de Haan, Richard D. Hayes
The study by Klenfeldt et al.1 in this issue presents a valuable long-term picture of obsessive-compulsive disorder (OCD) stability and comorbidities over a nearly 50-year follow-up period. With its appropriate (and possibly near-unique) three-generation authorship, the paper illustrates the need for, and challenges facing, long-duration prospective studies in mental health research. Although the importance
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Comparative responses to 17 different antidepressants in major depressive disorder: Results from a 2‐year long‐term nation‐wide population‐based study emulating a randomized trial Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-21 Lars Vedel Kessing, Simon Christoffer Ziersen, Frederik Mølkjær Andersen, Thomas Gerds, Esben Budtz‐Jørgensen
BackgroundLong‐term studies comparing nonresponse to antidepressants for major depressive disorder (MDD) are lacking.AimsTo present systematic population‐based nation‐wide register data on comparative 2‐year non‐response within six antidepressant drug classes and 17 different antidepressants in patients with MDD.MethodThe study included all 106,920 patients in Denmark with a first main index diagnosis
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Early exposure to cannabis and bipolar disorder incidence: Findings from a 22-year birth cohort study in Brazil Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-20 Alan Cristian Rodrigues Jorge, Bruno Braga Montezano, Kyara Rodrigues de Aguiar, Lucas Tavares Noronha, Daniel Prates Baldez, Devon Watts, Ana Maria Baptista Menezes, Fernando C. Wehrmeister, Helen Gonçalves, Maurício Kunz, Flávio Kapczinski, Ives Cavalcante Passos
Bipolar disorder is a chronic condition affecting millions of people worldwide. Currently, there is some evidence to suggest that cannabis use during adolescence may be an environmental risk factor for its onset, however inconsistencies have been observed across the literature. Considering this, we aimed to assess whether early lifetime cannabis is associated with subsequent bipolar disorder in young
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Antecedents of maternal pregnancy‐related anxiety trajectories: The FinnBrain birth cohort study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-19 Anja C. Huizink, Dora Lammassaari, Saara Nolvi, Riikka Korja, Linnea Karlsson, Hasse Karlsson, Eeva Leena Kataja
ObjectiveLittle is known about the normative courses of pregnancy‐related anxiety throughout pregnancy and their antecedents. We examined in a large scale pregnancy cohort which potentially distinct trajectories of pregnancy‐related anxiety across pregnancy can be identified, and which factors predict these trajectories.MethodsA general sample of pregnant women (n = 2928) from the FinnBrain Birth Cohort
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Patients with both cancer and psychosis—to what extent do they receive specialized palliative care Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-18 Jenny Bergqvist, Stina Hedskog, Christel Hedman, Torbjörn Schultz, Peter Strang
Schizophrenia and advanced cancer are complex conditions that impact life expectancy. This study aimed to examine the receipt of specialized palliative care (SPC) in patients with metastatic cancer and a coexisting diagnosis of psychosis compared to patients with cancer only. Secondary objectives included analyzing differences in emergency visits and place of death in relation to receipt of SPC.
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Unmet needs in mental healthcare for women with clinically significant symptoms of perinatal depression and/or anxiety during the COVID-19 pandemic Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-11 Raquel Costa, Ana Mesquita, Emma Motrico, Sara Domínguez-Salas, Pelin Dikmen-Yildiz, Sandra Saldivia, Eleni Vousoura, Ana Osorio, Claire A. Wilson, Rena Bina, Drorit Levy, Andri Christoforou, Maria Fernanda González, Camelia Hancheva, Ethel Felice, Tiago Miguel Pinto
Unmet needs in perinatal mental healthcare are an important public health issue particularly in the context of a stressful life event such as the COVID-19 pandemic but data on the extent of this problem are needed.
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The natural history of lifetime psychiatric disorders in patients with obsessive-compulsive disorder followed over half a century Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-08 Isak Fredén Klenfeldt, Gunnar Skoog, Johan Skoog, Ingmar Skoog
Few long-term studies have examined the life-time prevalence of comorbid psychiatric conditions in patients with obsessive-compulsive disorder (OCD). We therefore studied the frequency of comorbid psychiatric disorders, and their relation to onset and prognosis, in patients with OCD who were followed for almost half a century.
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Mentalizing psychiatric training Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-06 Peter Fonagy
In their remarkable paper, Castellini et al1 provide us with not so much a survey but a census of psychiatric trainees in Italy with a remarkable response rate of over 80% compared with a more quotidian comparison group of medical trainees at a similar point of their professional development. The comprehensiveness of their approach permits a tentative conclusion about the average mental state of psychiatric
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Key psychosocial issues in medical care Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-02-01 Giovanni A. Fava, Chiara Patierno, Nicoletta Sonino, Fiammetta Cosci
The aim of this review is to illustrate an innovative framework for assessing the psychosocial aspects of medical disorders within the biopsychosocial model. It is based on clinimetrics, the science of clinical measurements. It may overcome the limitations of DSM-5 in identifying highly individualized responses at the experiential, behavioral, and interpersonal levels.
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Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-24 O. Godin, E. Olié, G. Fond, B. Aouizerate, V. Aubin, F. Bellivier, R. Belzeaux, P. Courtet, C. Dubertret, E. Haffen, A. Lefrere, P. M. Llorca, M. Polosan, P. Roux, L. Samalin, R. Schwan, , M. Leboyer, B. Etain
Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal
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Sleep medicines are often prescribed for older adults (≥75 years) without appropriate dosing instructions: A nationwide retrospective register study in Finland Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-24 Sini-Tuulia Eronen, Terhi Kurko, Sirkka-Liisa Kivelä, Tiina Paunio, Marja Airaksinen, Tomi Rantamäki
Sleep medicines should be prescribed cautiously, accompanied by instructions that ensure appropriate use and reduce risks. This is especially important for older adults, for whom many of these medicines are classified as potentially inappropriate medicines.
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Can digital self-harm relate to suicidal thoughts and behaviors beyond physical self-harm? Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-22 Juan Wang, Ziqian Wei, Luxia Jia, Jiaao Yu, Yuanyuan Wang, Yaxuan Meng, Yi Feng, Runsen Chen
Digital self-harm (DiSH) is a recently identified self-harm distinct from physical self-harm (PSH, also known as non-suicidal self-injury, NSSI). Although prior research has shown that DiSH was associated with suicidal thoughts and behaviors (STBs), it was still unclear whether DiSH has a unique association with STBs after controlling for PSH.
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Lithium use and bone health in women with bipolar disorder: A cross-sectional study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-19 Lana J. Williams, Bruno Agustini, Amanda L. Stuart, Julie A. Pasco, Jason M. Hodge, Rasika M. Samarasinghe, Ottar Bjerkeset, Shae E. Quirk, Heli Koivumaa-Honkanen, Risto Honkanen, Jeremi Heikkinen, Michael Berk
Several psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to investigate the association between lithium use and bone health in a group of women with bipolar disorder.
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Dose response relationship between lithium serum levels during pregnancy and birth outcomes Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-18 Lisanne Schrijver, Astrid M. Kamperman, Hilmar Bijma, Inge L. van Kamp, Richard Wesseloo, Witte J. G. Hoogendijk, Veerle Bergink, Eline M. P. Poels
Lithium use during pregnancy reduces the risk of mood episodes in the perinatal period for women with bipolar disorder. Some previous studies found deleterious effects of intrauterine lithium exposure on birth outcomes, yet little is known about a dose response relationship. The current study investigated the influence of maternal lithium serum levels on birth outcomes.
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Cover Image Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-15 Anders Jorgensen, Emma Neble Larsen, Mathilde Marie Brünnich Sloth, Lars Vedel Kessing, Merete Osler
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Embracing evolutionary theories of autism: Implications for psychiatry Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-15 Tanya L. Procyshyn, Alex Tsompanidis, Simon Baron-Cohen
1 BACKGROUND Autism is one of most common disabilities, with recent estimates that 1 in 36 children1 have an autism diagnosis and late diagnoses in adults also increasing. The DSM-5 diagnostic criteria for autism now include sensory sensitivities alongside the long-established criteria of social and communication challenges and repetitive and restrictive behaviours and interests. Most clinicians no
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A comparison of the original major depression inventory with a modified version: A Danish validation study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-16 Henrik Schou Pedersen, Karl Bang Christensen, Anders Prior, Kaj Sparle Christensen
The Major Depression Inventory (MDI) is a patient-reported outcome measure used by general practitioners to assist with diagnosing and evaluation of the severity of a patient's depression. However, recent studies have questioned the structural validity of the MDI.
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Risk factors for mortality in patients admitted to a psychiatric acute ward: A prospective cohort study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-15 Maria Fagerbakke Strømme, Christoffer Bartz-Johannessen, Eirik Kjelby, Lars Mehlum, Arnstein Mykletun, Rune Andreas Kroken, Erik Johnsen, Rolf Gjestad
Associations between psychiatric disorders and mortality have been extensively studied, but limited evidence exists regarding influence of clinical characteristics on mortality risk, at the time of acute psychiatric hospitalization.
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The development of type 2 diabetes management in people with severe mental illness in the Capital Region of Denmark from 2001 to 2015 Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-06 Catrine Bakkedal, Frederik Persson, Mikkel Bring Christensen, Margit Kriegbaum, Grimur Høgnason Mohr, John Sahl Andersen, Bent Struer Lind, Christen Lykkegaard, Volkert Siersma, Maarten Pieter Rozing
Type 2 diabetes (T2D) treatment has changed markedly within the last decades. We aimed to explore whether people with severe mental illness (SMI) have followed the same changes in T2D treatment as those without SMI, as multiple studies suggest that people with SMI receive suboptimal care for somatic disorders.
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The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-03 Giovanni Castellini, Livio Tarchi, Emanuele Cassioli, Valdo Ricca, Giovanni Abbate Daga, Andrea Aguglia, Umberto Albert, Annarita Atti, Stefano Barlati, Giuseppe Blasi, Claudia Carmassi, Giuseppe Carrà, Pasquale De Fazio, Chiara De Panfilis, Giorgio Di Lorenzo, Silvia Ferrari, Arianna Goracci, Carla Gramaglia, Mario Luciano, Giovanni Martinotti, Marco Menchetti, Giulia Menculini, Maria Giulia Nanni
A better characterization of educational processes during psychiatry training is needed, both to foster personal resilience and occupational proficiency.
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Cancer mortality and morbidity among patients with schizophrenia: A hospital-based cohort study, 1992–2020 Acta Psychiat. Scand. (IF 6.7) Pub Date : 2024-01-03 M. Drevinskaite, A. Kaceniene, A. Patasius, R. Stukas, A. Germanavicius, E. Miseikyte, V. Urbonas, G. Smailyte
Due to the inconsistency of the evidence about the cancer risk among patients with schizophrenia, the aim of this study was to analyse cancer mortality and morbidity in patients with schizophrenia treated in a single centre in Lithuania during the study period of 1992–2020.
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Social determinants in prenatal antidepressant use and continuation: Systematic review and meta-analysis Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-25 Ketevan Marr, Charlotte Maguet, Honor Scarlett, Rosemary Dray-Spira, Caroline Dubertret, Florence Gressier, Anne-Laure Sutter-Dallay, Maria Melchior, Judith van der Waerden
Depression is one of the most common co-morbidities during pregnancy; with severe symptoms, antidepressants are sometimes recommended. Social determinants are often linked with antidepressant use in the general population, and it is not known if this is the case for pregnant populations. Our objective was to determine if social determinants are associated with prenatal antidepressant intake via a systematic
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Association of maternal and paternal personality disorders with risk of mental disorders in children: A nationwide, register-based cohort study of 1,406,965 children Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-25 Ida Christine Tholstrup Gjøde, Thomas Munk Laursen, Anne Dorothee Müller, Anne Ranning, Mala Moszkowicz, Nicoline Hemager, Helene Speyer, Carsten Hjorthøj, Merete Nordentoft, Anne Amalie Elgaard Thorup
Knowledge of the association between parental personality disorders and mental disorders in children is limited. To examine the association between parental personality disorders and the risk of mental disorders in offspring.
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Effects of maternal modafinil treatment on fetal development and neonatal growth parameters — a multicenter case series of the European Network of Teratology Information Services (ENITS) Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-18 Marlies Onken, Lukas Lohse, Bénédicte Coulm, Delphine Beghin, Jonathan L. Richardson, Eva Bermejo-Sánchez, Cristina Aguilera, Montserrat Bosch, Matteo Cassina, Laurent Chouchana, Marco De Santis, Mine Kadioglu Duman, M. Zafer Gören, Diana Johnson, Annie Pierre Jonville Bera, Yusuf C. Kaplan, Debra Kennedy, Susan Kwok, Isabelle Lacroix, Marion Lepelley, Alessandra Pistelli, Christof Schaefer, Bernke
In recent years, safety concerns about modafinil exposure during pregnancy have emerged. In particular, increased risks for major congenital anomalies (MCA) and impaired fetal growth were reported, although study results were conflicting. Our investigation aims to examine previously reported safety signals.
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Maintenance treatment of psychotic depression: Is antipsychotic medication needed? Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-12 Anthony J. Rothschild
A.J.R. has received grant or research support from Janssen, Otsuka, Compass Pathways, and the Irving S. and Betty Brudnick Endowed Chair in Psychiatry; is a consultant to Daiichi Sankyo, Inc., Sage Therapeutics, Xenon Pharmaceuticals, Neumora Therapeutics, Zydus Pharmaceuticals (USA), Inc., Sandoz, Inc., and Lupin Pharmaceuticals, Inc.; and has received royalties for the Rothschild Scale for Antidepressant
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Borderline personality disorder and the diagnostic co-occurrence of mental health disorders and somatic diseases: A controlled prospective national register-based study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-10 L. H. Hastrup, P. Jennum, R. Ibsen, J. Kjellberg, E. Simonsen
Information on borderline personality disorder (BPD) and its comorbidities is often limited to concentrate on a few diagnoses. The aim of the study was to use national register data to investigate all diagnostic co-occurring mental health disorders and somatic diseases 3 years before and after initial BPD diagnosis compared with a matched control group.
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A naturalistic effectiveness study of maintenance therapies for the bipolar disorders Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-10 Michael J. Spoelma, Joanne Leidreiter, Adam Bayes, Artin Jebejian, Gordon Parker
Treatment decision-making for individuals with bipolar disorder can be difficult. Recommendations from clinical practice guidelines can be affected by multiple methodological limitations, while pharmaco-epidemiological data suggest great variety in prescription practices across regions. Given these inconsistencies, this study aimed to provide an alternative perspective on the effectiveness of common
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Clinical and sociodemographic features in offspring aged 0–3 years of mothers with schizophrenia spectrum disorders. A descriptive cross-sectional study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-10 Emilie Edvardsen, Mala Moszkowicz, Anne Lise Olsen, Michella Heinrichsen, Anne Katrine Pagsberg
Offspring of parents with schizophrenia spectrum disorders (SSD) have an increased risk of neurodevelopmental disturbances. However, the ability to provide very early interventions to support these children and their families requires profound knowledge regarding characteristic features of both the parents and their offspring. Information on this subject is currently sparse. The aim of the present
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Trends in psychotherapy utilization for perinatal mental health 2008–2020 Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-06 Karen M. Tabb, Dana C. Beck, Xiaosong Zhang, Stephanie Hall, Anca Tilea, Gloria Sugg, Amy Schroeder, Vanessa K. Dalton, Kara Zivin
1 INTRODUCTION Psychotherapy is an evidence-based non-pharmacological treatment and is an effective and appropriate treatment for perinatal mental health disorders.1 Psychotherapy initiated in pregnancy can have numerous positive effects, such as reducing risks for postpartum depression, improving relationship quality, preventing anxiety and treating depression through remission.2 Despite these facts
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Disease trajectory of high neuroticism and the relevance to psychiatric disorders: A retro-prospective cohort study Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-12-06 Ding Xia, Xin Han, Yu Zeng, Jingru Wang, Kelin Xu, Tiejun Zhang, Yanfeng Jiang, Xingdong Chen, Huan Song, Chen Suo
Neuroticism is a psychological personality trait that has a significant impact on public health and is also a potential predisposing factor for adverse disease outcomes; however, comprehensive studies of the subsequently developed conditions are lacking. The starting point of disease trajectory in terms of genetic variation remains unclear.
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Reduced mitochondrial respiratory capacity in patients with acute episodes of bipolar disorder: Could bipolar disorder be a state-dependent mitochondrial disease? Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-29 Anna Giménez-Palomo, Mariona Guitart-Mampel, Ana Meseguer, Roger Borràs, Francesc Josep García-García, Esther Tobías, Laura Valls, Xavier Alsina-Restoy, Gemma Roqué, Ester Sánchez, Josep Roca, Gerard Anmella, Marc Valentí, Lorenzo Bracco, Helena Andreu, Sergi Salmerón, Lluc Colomer, Joaquim Radua, Norma Verdolini, Michael Berk, Eduard Vieta, Glòria Garrabou, Isabella Pacchiarotti
Bipolar disorder (BD) is a chronic and recurrent disease characterized by acute mood episodes and periods of euthymia. The available literature postulates that a biphasic dysregulation of mitochondrial bioenergetics might underpin the neurobiology of BD. However, most studies focused on inter-subject differences rather than intra-subject variations between different mood states. To test this hypothesis
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Comment on “Association between late-life depression or depressive symptoms and stroke morbidity in elders: A systematic review and meta-analysis of cohort studies” Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-27 Tian-Chao Chen, Xiao-Ming Zhang, Xin-Yi Liu, Yun-Feng Bai, Yue-Ying Feng, Xin-Juan Wu
With great interest, we have thoroughly reviewed a recent systematic review and meta-analysis conducted by Cai et al.,1 which effectively pooled the association between depressive symptoms and stroke in the elderly population. The authors have successfully identified compelling evidence that late-life depression or depressive symptoms significantly contribute to the risk of stroke among older individuals
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Prenatal antidepressant exposure and the risk of decreased gestational age and lower birthweight: A polygenic score approach to investigate confounding by indication Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-21 Anna-Sophie Rommel, Birgitte Dige Semark, Xiaoqin Liu, Kathrine Bang Madsen, Esben Agerbo, Trine Munk-Olsen, Liselotte Vogdrup Petersen, Veerle Bergink
Prenatal antidepressant exposure has been associated with lower gestational age and birthweight. Yet, unmeasured residual confounding may inflate this association. We explored if maternal genetic liability for major depression explains part of the association of antidepressant use in pregnancy with lower gestational age and birthweight.
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Prescription patterns in unipolar depression: A nationwide Danish register-based study of 113,175 individuals followed for 10 years Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-21 Anders Jorgensen, Emma Neble Larsen, Mathilde Marie Brünnich Sloth, Lars Vedel Kessing, Merete Osler
Evidence-based use of antidepressant medications is of major clinical importance. We aimed to uncover precription patterns in a large cohort of patients with unipolar depression.
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Electroconvulsive therapy related anxiety in patients with depression: The influence of cognitive coping styles Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-20 Chelsea Verledens, Jasmien Obbels, Liese Van den Eynde, Eva Pilato, Shauni Verspecht, Kaat Hebbrecht, Emma De Schuyteneer, Kristof Vansteelandt, Pascal Sienaert
Electroconvulsive therapy (ECT) related anxiety (ERA) is a common phenomenon with high individual variability. The way patients cognitively cope with the prospects of receiving ECT could be a mechanism explaining individual differences in ERA. Cognitive coping like monitoring (information seeking, paying attention to consequences) and blunting (seeking distraction and reassurance) has been linked to
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Effect of severity of depression on augmentation of antidepressant medication in young adults with depression Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-20 Pasi Lampela, Antti Tanskanen, Markku Lähteenvuo, Jari Tiihonen, Heidi Taipale
Antipsychotics (AP) have been used to augment antidepressant (AD) medication in treatment-resistant depression. In this study we examined factors (including severity of depression and initial antidepressant) affecting AP augmentation, as well as which APs were initiated as augmentation in young adults.
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Adaptive and maladaptive emotion regulation in bipolar disorder Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-20 Thomas Frodl
Emotion regulation (ER) is crucial for mental well-being, especially in periods of high stress. Recent research shows that not only is the type of ER strategy important, but that psychological flexibility also plays an important role in whether ER is effective and protective.1 Therefore, ER skills training needs to be adapted on a case-by-case basis to take into account dispositional and contextual
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Brain-derived neurotrophic factor levels in perinatal depression: A systematic review and meta-analysis Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-16 Kyana Jafarabady, Arman Shafiee, Razman Arabzadeh Bahri, Shahryar Rajai Firouzabadi, Ida Mohammadi, Mohammad Javad Amini
This systematic review and meta-analysis aim to synthesize the available evidence and determine the overall brain-derived neurotrophic factor (BDNF) levels in individuals diagnosed with perinatal depression (PND).
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Prediction models of suicide and non-fatal suicide attempt after discharge from a psychiatric inpatient stay: A machine learning approach on nationwide Danish registers Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-14 Sara Dorthea Nielsen, Rune H. B. Christensen, Trine Madsen, Karen-Inge Karstoft, Line Clemmensen, Michael E. Benros
To develop machine learning models capable of predicting suicide and non-fatal suicide attempt as separate outcomes in the first 30 days after discharge from a psychiatric inpatient stay.
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Cognitive deficits among people with schizophrenia and prediabetes or diabetes Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-10 Alexander Panickacheril John, Thynn Mya, Darren Haywood
Both type 2 diabetes mellitus (T2DM) and schizophrenia are known to be associated with cognitive deficits. The impact of the comorbidities of T2DM or prediabetes (PD) on cognition among people with schizophrenia has been poorly researched. We evaluated the cognitive functioning of patients with schizophrenia and PD or T2DM and compared them to patients with schizophrenia with normal blood sugar.
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Women with depression in pregnancy or a history of depression have decreased quality of mentalization in the speech to their infants Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-06 Lavinia Rebecchini, Rebecca H. Bind, Beatrice Allegri, Arianna Zamparelli, Alessandra Biaggi, Katie Hazelgrove, Sarah Osborne, Susan Conroy, Susan Pawlby, Vaheshta Sethna, Carmine M. Pariante
Our study aims to understand whether depression, either in pregnancy or lifetime, affects cognitive biases (comprising the attentional focus and affective state) and mentalizing features (ability to understand children's internal mental states, thereby detecting and comprehending their behavior and intention), in maternal speech during mother-infant interaction in the first postnatal year.
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Smoking and severe mental illness: Drawing inference on the directionality of the association requires careful consideration of the temporality of the data. Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-07 Marie Krab Lund,Mikkel Højlund,Lars Christian Lund
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Pregnancy intention in relation to maternal and neonatal outcomes in women with versus without psychiatric diagnoses Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-07 Noralie N. Schonewille, Nini H. Jonkman, Anne A. M. W. van Kempen, Maria G. van Pampus, Odile A. van den Heuvel, Birit F. P. Broekman
Studies have identified adverse maternal and neonatal outcomes for women with psychiatric disorders. Additionally, psychiatric disorders may pose an increased risk for unintended pregnancies (UPs) which in turn may also impact negatively on outcomes. The present study aims to compare the incidence of UPs in women with versus without current/past psychiatric diagnoses and investigates whether psychiatric
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Antipsychotics in the maintenance phase for psychotic depression Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-11-06 Ahmed Al-Wandi, Mikael Landén, Axel Nordenskjöld
This study aimed to associate antidepressants with versus without antipsychotics with readmission and suicide in patients with psychotic unipolar depression.
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Meta-analysis of clinical risk factors for suicide among people presenting to emergency departments and general hospitals with suicidal thoughts and behaviours Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-30 Cameron Grover, Jacqueline Huber, Matthew Brewer, Ashna Basu, Matthew Large
Suicidal thoughts and behaviours (STB) are a common reason for presentation to emergency departments and general hospitals. A meta-analysis of the strength of clinical risk factors for subsequent suicide might aid understanding of suicidal behaviour and help suicide prevention.
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Outcomes of electroconvulsive therapy in patients with depressive symptoms with versus without comorbid personality disorders/traits: A systematic review and meta-analysis Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-29 Stefano Ferrea, Georgios Petrides, Yamina Ehrt-Schäfer, Jules Angst, Erich Seifritz, Sebastian Olbrich, Georgios Schoretsanitis
To assess electroconvulsive therapy (ECT) outcomes in patients affected by depressive symptoms with versus without additional comorbid personality disorders/traits.
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Clozapine augmentation with long-acting antipsychotic injections: A case series and systematic review Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-29 Ebenezer Oloyede, Aikaterini Dima, David Taylor, Henry Cheung, Olubanke Dzahini, Sukhi Shergill, Eromona Whiskey
Up to 30% of patients with a diagnosis of treatment-resistant psychosis remain symptomatic despite an optimal trial with the gold standard treatment, clozapine. Emerging evidence suggests the clinical utility of long-acting injections (LAI) in such clinical scenarios. In this study, we aimed to describe clozapine augmentation with LAIs in an inner London hospital and explore the literature on the clinical
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No association between methylphenidate use and psychotic experiences in a population-based sample of adolescents at risk of emotional and behavioral problems Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-29 Milan Zarchev, Diandra C. Bouter, Nina H. Grootendorst-van Mil
1 INTRODUCTION Methylphenidate is a psychostimulant commonly prescribed for the symptoms of attention-deficit/hyperactivity disorder (ADHD). Subclinical symptoms of psychosis, referred to as psychotic experiences, have been reported in individuals with ADHD when prescribed methylphenidate.1 Amphetamines are hypothesized to trigger or exacerbate latent psychosis vulnerabilities among those predisposed
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Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-23 Benedicte M. W. Johannsen, Janne Tidselbak Larsen, Xiaoqin Liu, Kathrine Bang Madsen, Merete Lund Mægbæk, Clara Albiñana, Veerle Bergink, Thomas M. Laursen, Bodil H. Bech, Preben Bo Mortensen, Merete Nordentoft, Anders D. Børglum, Thomas Werge, David M. Hougaard, Esben Agerbo, Liselotte Vogdrup Petersen, Trine Munk-Olsen
We quantified relative and absolute risks of postpartum psychiatric episodes (PPE) following risk factors: Young age, past personal or family history of psychiatric disorders, and genetic liability.
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Safety of and response to electroconvulsive therapy during pregnancy: Results from population-based nationwide registries Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-18 Tor Arnison, Olof Rask, Axel Nordenskjöld, Pouya Movahed Rad
Psychiatric disorders are common during pregnancy, affecting up to 16% of pregnant women. Severe depression and anxiety have significant negative effects on the health of both the mother and the developing fetus. Electroconvulsive therapy (ECT) is considered a treatment option for pregnant women with severe psychiatric disorders when other treatments have been ineffective or pose risks to the fetus
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Benzodiazepines in elderly patients Acta Psychiat. Scand. (IF 6.7) Pub Date : 2023-10-12 Giovanni A. Fava
For a long time, benzodiazepines have provided an effective treatment of anxiety disorders and sleep disturbances.1 They were also found to be helpful in anxious depression, bipolar disorder, catatonia, and in a number of medical conditions, such as epilepsy and alcohol withdrawal.1 In the 90s, introduction of second-generation antidepressants provided more expensive modalities of addressing anxiety