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Altered corollary discharge in the auditory cortex could reflect louder inner voice experience in patients with verbal hallucinations, a pilot fMRI study Schizophr. Res. (IF 4.5) Pub Date : 2024-03-05 Massoud Stephane, Mario Dzemidzic, Gihyun Yoon
Wide range of evidence associates auditory verbal hallucinations (AVH) with frontotemporal corollary discharge deficit. AVH likely reflect altered experiences of the inner voice and are phenomenologically diverse. The aspects of hallucinations (and related inner voice experiences) that could be explained by this deficit remain unclear. To address this important subject, we examined the temporal cortex
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Intrinsic motivation predicts cognitive and functional gains during coordinated specialty care for first-episode schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-03-04 Thanh P. Le, Joseph Ventura, Kenneth L. Subotnik, Keith H. Nuechterlein
Coordinated Specialty Care (CSC) and embedded group therapeutic interventions have been effective in improving outcomes for individuals experiencing recent first-episode schizophrenia, including cognitive performance and functioning. Treatment response varies substantially, with some patients experiencing limited or no improvement. Motivation has emerged as a key determinant of treatment engagement
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A naturalistic cohort study of first-episode schizophrenia spectrum disorder: A description of the early phase of illness in the PSYSCAN cohort Schizophr. Res. (IF 4.5) Pub Date : 2024-03-02 Margot I.E. Slot, Hendrika H. van Hell, Inge Winter-van Rossum, Paola Dazzan, Arija Maat, Lieuwe de Haan, Benedicto Crespo-Facorro, Birte Glenthøj, Stephen M. Lawrie, Colm McDonald, Oliver Gruber, Thérèse van Amelsvoort, Celso Arango, Tilo Kircher, Barnaby Nelson, Silvana Galderisi, Mark Weiser, Gabriele Sachs, Anke Maatz, Rodrigo A. Bressan, Jun Soo Kwon, Romina Mizrahi, the PSYSCAN Consortium, Philip
We examined the course of illness over a 12-month period in a large, international multi-center cohort of people with a first-episode schizophrenia spectrum disorder (FES) in a naturalistic, prospective study (PSYSCAN). Patients with a first episode of schizophrenia, schizoaffective disorder (depressive type) or schizophreniform disorder were recruited at 16 institutions in Europe, Israel and Australia
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A letter to the editor: The effects of alcohol use on brain glutamate in first episode psychosis Schizophr. Res. (IF 4.5) Pub Date : 2024-03-01 Bridget King, Matthew J. Kempton, Brian V. Broberg, Kate Merritt, Gareth J. Barker, David J. Lythgoe, Rocio Perez-Iglesias, Lone Baandrup, Signe W. Düring, James M. Stone, Egill Rostrup, Iris E. Sommer, Birte Glenthøj, René S. Kahn, Paola Dazzan, Philip K. McGuire, Alice Egerton
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Speech markers to predict and prevent recurrent episodes of psychosis: A narrative overview and emerging opportunities Schizophr. Res. (IF 4.5) Pub Date : 2024-02-29 Farida Zaher, Mariama Diallo, Amélie M. Achim, Ridha Joober, Marc-André Roy, Marie-France Demers, Priya Subramanian, Katie M. Lavigne, Martin Lepage, Daniela Gonzalez, Irnes Zeljkovic, Kristin Davis, Michael Mackinley, Priyadharshini Sabesan, Shalini Lal, Alban Voppel, Lena Palaniyappan
Preventing relapse in schizophrenia improves long-term health outcomes. Repeated episodes of psychotic symptoms shape the trajectory of this illness and can be a detriment to functional recovery. Despite early intervention programs, high relapse rates persist, calling for alternative approaches in relapse prevention. Predicting imminent relapse at an individual level is critical for effective intervention
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Measurement invariance of the Revised-Green Paranoid Thought Scale across Black and White Americans Schizophr. Res. (IF 4.5) Pub Date : 2024-02-29 J Wolny, Alexandra B. Moussa-Tooks, Allen J. Bailey, Angus W. MacDonald III, Joshua E. Mervis, William P. Hetrick
Given the culturally diverse landscape of mental healthcare and research, ensuring that our psychological constructs are measured equivalently across diverse populations is critical. One construct for which there is significant potential for inequitable assessment is paranoia, a prominent feature in psychotic disorders that can also be driven by culture and racial marginalization. This study examined
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Anthropometry in antipsychotic-naïve first-episode psychosis patients: An exploratory approach to the role of environmental early life events in two independent samples Schizophr. Res. (IF 4.5) Pub Date : 2024-02-29 Clemente Garcia-Rizo, Benedicto Crespo-Facorro, Cristina Oliveira, Marcos Gómez-Revuelta, Brian Kirkpatrick, Jacqueline Mayoral-van Son, Laura Cayón de la Hoz, Marina Garriga, Nathalia Garrido-Torres, Miguel Bernardo, Emilio Fernandez-Egea, Javier Vázquez-Bourgon
Patients with schizophrenia exhibit a reduced life expectancy mainly due to medical-related pathologies which might have been initiated due to stressful events during fetal development. Indeed, intra-uterus growth patterns predict anthropometric measures in adulthood, describing risk factors for schizophrenia and metabolic disorders. We aim to evaluate anthropometric values in two cohorts of antipsychotic-naïve
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The diagnostic accuracy of screening for psychosis spectrum disorders in behavioral health clinics integrated into primary care Schizophr. Res. (IF 4.5) Pub Date : 2024-02-28 Mark Savill, Rachel L. Loewy, Tara A. Niendam, A. Jonathan Porteus, Adi Rosenthal, Sarah Gobrial, Monet Meyer, Khalima A. Bolden, Tyler A. Lesh, J. Daniel Ragland, Cameron S. Carter
Screening for psychosis spectrum disorders in primary care could improve early identification and reduce the duration of untreated psychosis. However, the accuracy of psychosis screening in this setting is unknown. To address this, we conducted a diagnostic accuracy study of screening for psychosis spectrum disorders in eight behavioral health services integrated into primary care clinics. Patients
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Symptomatic remission and recovery in major psychosis: Is there a role for BDNF? A secondary analysis of the LABSP cohort data Schizophr. Res. (IF 4.5) Pub Date : 2024-02-28 Ulker Isayeva, Mirko Manchia, Roberto Collu, Diego Primavera, Luca Deriu, Edoardo Caboni, Novella Maria Iaselli, Davide Sundas, Massimo Tusconi, Federica Pinna, Pasquale Paribello, Maria Scherma, Claudia Pisanu, Anna Meloni, Clement C. Zai, Donatella Congiu, Alessio Squassina, Walter Fratta, Paola Fadda, Bernardo Carpiniello
Remission, relapse prevention, and clinical recovery are crucial areas of interest in schizophrenia (SCZ) research. Although SCZ is a chronic disorder with poor overall outcomes, years of research demonstrated that recovery is possible. There are considerable data linking brain-derived neurotrophic factor (BDNF) to SCZ, however, evidence on the role of BDNF in remission in SCZ is scarce. This secondary
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Natural language processing for defining linguistic features in schizophrenia: A sample from Turkish speakers Schizophr. Res. (IF 4.5) Pub Date : 2024-02-27 Tuğçe Çabuk, Nurullah Sevim, Emre Mutlu, A. Elif Anıl Yağcıoğlu, Aykut Koç, Timothea Toulopoulou
Natural language processing (NLP) provides fast and accurate extraction of features related to the language of schizophrenia. We utilized NLP methods to test the hypothesis that schizophrenia is associated with altered linguistic features in Turkish, a non-Indo-European language, compared to controls. We also explored whether these possible altered linguistic features were language-dependent or -independent
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DRESS syndrome, seizures, and myocarditis on low dose clozapine – A case report Schizophr. Res. (IF 4.5) Pub Date : 2024-02-26 Simran Arora, Satish Suhas, Guru S. Gowda, Venkata Senthil Kumar Reddi, John P. John
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The effectiveness of public health interventions, initiatives, and campaigns designed to improve pathways to care for individuals with psychotic disorders: A systematic review Schizophr. Res. (IF 4.5) Pub Date : 2024-02-26 Rhiannon Murden, Sophie M. Allan, Jo Hodgekins, Sheri Oduola
Lengthy duration of untreated psychosis (DUP) and duration of untreated illness (DUI) in people at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) is associated with poorer outcomes. However, individuals with FEP often experience negative pathways to care involving contacts with police, crisis services and requiring compulsory admissions, and evidence suggests individuals
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Moral learning and positive schizotypy: Social cognitive mechanisms in psychosis- proneness Schizophr. Res. (IF 4.5) Pub Date : 2024-02-24 Wanchen Zhao, Tyrone D. Cannon
Delusional thoughts such as paranoia and conspiratorial thinking reflect beliefs in others' intentions to do harm. Given the integral role of harm evaluation in moral cognition, a better understanding of how psychosis-prone individuals process others' moral characters may provide insights into social cognitive mechanisms of these types of delusions. An online sample of 293 participants was drawn from
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Acculturation and clinical symptoms of schizophrenia among Latine adults in the United States Schizophr. Res. (IF 4.5) Pub Date : 2024-02-24 Lize Tibiriçá, Jordan Kohn, Molly Patapoff, Allison P. Williams, Barton W. Palmer, Concepcion Barrio
Research on acculturation and schizophrenia spectrum disorders has yielded inconsistent findings. This study aimed to clarify the influence of acculturation on symptomatology in Latine individuals with schizophrenia in the United States. The analysis involved cross-sectional data from Latine ( = 120) and non-Latine White ( = 60) adults with schizophrenia in San Diego, California. Participants completed
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A new schizophrenia screening instrument based on evaluating the patient's writing Schizophr. Res. (IF 4.5) Pub Date : 2024-02-23 Zulai Peng, Qingjun Li, Xinglan Liu, Huangzhiheng Zhang, Manli Ran, Maohang Liu, Xiaolin Tan, Mark J. Stein
Formal Thought Disorder (FTD) is a defining feature of schizophrenia, which is often assessed through patients' speech. Meanwhile, the written language is less studied. The aim of the present study is to establish and validate a comprehensive clinical screening scale, capturing the full variety of empirical characteristics of writing in patients with schizophrenia. The 16-item Screening Instrument
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Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-02-23 Ville Mäkipelto, Annamari Tuulio-Henriksson, Christian Hakulinen, Solja Niemelä, Markku Lähteenvuo, Asko Wegelius, Tuula Kieseppä, Erkki Isometsä, Jari Tiihonen, Olli Kampman, Kaisla Lahdensuo, Atiqul Mazumder, Jaana Suvisaari, Minna Holm
Schizophrenia is characterized by cognitive impairment affecting everyday functioning. Earlier research has hypothesized that antidepressants may associate with better cognitive functioning, but results are mixed. This study explored the association between antidepressant use and cognitive performance in terms of reaction time and visual learning in a clinical sample. In addition, we examined benzodiazepine
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An ecological momentary cognitive assessment study of over-attribution of threat and suicide risk factors in people with serious mental illness Schizophr. Res. (IF 4.5) Pub Date : 2024-02-23 Emma M. Parrish, Amy Pinkham, Raeanne C. Moore, Philip D. Harvey, Eric Granholm, Scott Roesch, Thomas Joiner, Colin A. Depp
People with serious mental illness (SMI; schizophrenia, schizoaffective disorder, bipolar disorder) are at increased risk of suicidal ideation (SI). Over-attribution of social threat, or attributing threatening emotions to neutral faces, may contribute to social isolation through increased social avoidance and decreased social approach motivation. These factors are related to suicide, as well as perceived
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Interplay between childhood trauma, bodily self-disturbances, and clinical phenomena in schizophrenia spectrum disorders: A network analysis Schizophr. Res. (IF 4.5) Pub Date : 2024-02-22 Lénie J. Torregrossa, Jinyuan Liu, Kristan Armstrong, Stephan Heckers, Julia M. Sheffield
Bodily self-disturbances have long been considered central to schizophrenia. Exposure to childhood trauma has been linked to the development of both psychosis and bodily self-disturbances, yet little work has examined the role of bodily self-disturbances in the relationship between childhood trauma and schizophrenia symptomatology. This study uses network analysis to bridge this gap. Networks were
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Psychotic-like experiences predict the perceived intent to seek treatment: A network perspective Schizophr. Res. (IF 4.5) Pub Date : 2024-02-22 Błażej Misiak, Dorota Frydecka
We aimed to investigate as to whether psychotic-like experiences (PLEs) predict the perceived intent to seek treatment. Our secondary aim was to explore which PLEs predict the perceived need to seek treatment using a network analysis. The study was based on a community sample of individuals with a negative history of psychiatric treatment. At baseline, they completed questionnaires recording the presence
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Trajectories and predictors of response to social cognition training in people with schizophrenia: A proof-of-concept machine learning study Schizophr. Res. (IF 4.5) Pub Date : 2024-02-21 Kathleen Miley, Michael V. Bronstein, Sisi Ma, Hyunkyu Lee, Michael F. Green, Joseph Ventura, Christine I. Hooker, Mor Nahum, Sophia Vinogradov
Social cognition training (SCT) can improve social cognition deficits in schizophrenia. However, little is known about patterns of response to SCT or individual characteristics that predict response. 76 adults with schizophrenia randomized to receive 8–12 weeks of remotely-delivered SCT were included in this analysis. Social cognition was measured with a composite of six assessments. Latent class growth
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Changes in sedative burden at discharge in hospitalised patients experiencing psychotropic polypharmacy Schizophr. Res. (IF 4.5) Pub Date : 2024-02-20 Ruby Tszwai Au, Elizabeth Hotham, Adrian Esterman, Sepehr Shakib, Vijayaprakash Suppiah
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Effect of lifestyle modification intervention (LMI) on metabolic syndrome in schizophrenia in a residential mental health care setting–A mixed method study Schizophr. Res. (IF 4.5) Pub Date : 2024-02-19 Jothimani Gurusamy, Sailaxmi Gandhi, Dinakaran Damodharan, Marimuthu Palaniappan, Venkatasubramanian Ganesan
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Advancing equity & access for psychosis care in Massachusetts: Proceedings from the 2023 Mass-STEP Conference Schizophr. Res. (IF 4.5) Pub Date : 2024-02-19 Iqra Imam, Kelsey A. Johnson, Ananya Saluja, Raquelle I. Mesholam-Gately, Dost Öngür, Margaret Guyer, Matcheri S. Keshavan
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Tardive dyskinesia's under-recognition in the era of COVID-19 Schizophr. Res. (IF 4.5) Pub Date : 2024-02-19 Derek Zhang, Samuel Law, Saadia Sediqzadah
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Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-02-19 Jihan K. Zaki, Santiago G. Lago, Benedetta Spadaro, Nitin Rustogi, Shiral S. Gangadin, Jiri Benacek, Hemmo A. Drexhage, Lot D. de Witte, René S. Kahn, Iris E.C. Sommer, Sabine Bahn, Jakub Tomasik
Schizophrenia is one of the most debilitating mental disorders, and its diagnosis and treatment present significant challenges. Several clinical trials have previously evaluated the effectiveness of simvastatin, a lipid-lowering medication, as a novel add-on treatment for schizophrenia. However, treatment effects varied highly between patients and over time. In the present study, we aimed to identify
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Neurocognition and social cognition in youth and young adults at ultra-high-risk for psychosis and bipolar disorder Schizophr. Res. (IF 4.5) Pub Date : 2024-02-17 E. Bora, M.S. Eyuboglu, E. Cesim, M. Demir, B. Yalincetin, C. Ermis, S. Özbek Uzman, E. Sut, C. Demirlek, B. Verim, B. Baykara, A. Akay, N. İnal, B.B. Akdede
Schizophrenia and bipolar disorder are associated with significant deficits in neurocognition and social cognition. Unlike the studies in chronic stages of these disorders, very limited information is available regarding neurocognitive and social-cognitive impairment before the onset of bipolar disorder. Our main aim was to investigate the differences in neurocognition and social cognition between
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Cortical volume abnormalities in schizophrenia: Correlations with symptoms and cognitive impairment Schizophr. Res. (IF 4.5) Pub Date : 2024-02-17 María Ángeles García-León, Paola Fuentes-Claramonte, Joan Soler-Vidal, Nuria Ramiro-Sousa, Pilar Salgado-Pineda, Josep Salavert, Llanos Torres, Amalia Guerrero-Pedraza, Josep Tristany, Andriana Karuk, Lucila Barbosa, Pablo Del Olmo-Encabo, Pedro Canut-Altemir, Josep Munuera, Salvador Sarró, Raymond Salvador, Peter J. McKenna, Edith Pomarol-Clotet
Schizophrenic symptoms are known to segregate into reality distortion, negative and disorganization syndromes, but the correlates of these syndromes with regional brain structural change are not well established. Cognitive impairment is a further clinical feature of schizophrenia, whose brain structural correlates are the subject of conflicting findings. 165 patients with schizophrenia were rated for
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Personal recovery in first-episode psychosis: Beyond clinical and functional recovery Schizophr. Res. (IF 4.5) Pub Date : 2024-02-16 Isolde L. Maas, Marc M. Bohlken, Shiral S. Gangadin, Bram-Sieben Rosema, Wim Veling, Nynke Boonstra, Lieuwe de Haan, Marieke J.H. Begemann, Sanne Koops
The concept of personal recovery after psychotic illness focuses more on patients' social and existential needs compared to traditional outcome measures including clinical and functional recovery. This research aims to contribute to a broad framework on (personal) recovery and associated factors. Data from 203 persons with symptomatic remission of their first-episode psychosis from the ongoing HAMLETT
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Antisaccade error rates in first-episode psychosis, ultra-high risk for psychosis and unaffected relatives of schizophrenia: A systematic review and meta-analysis Schizophr. Res. (IF 4.5) Pub Date : 2024-02-16 Merve Ekin, Gülden Akdal, Emre Bora
Antisaccade, which is described as looking at the opposite location of the target, is an eye movements paradigm used for assessing cognitive functions in schizophrenia. Initiation and sustainment of saccades in antisaccade are managed by frontal and parietal cortical areas. Antisaccade abnormalities are well-established findings in schizophrenia. However, studies in the early phases of psychotic disorders
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Psychopathology and psychosocial functioning among young people with first-episode psychosis and/or first-presentation borderline personality disorder Schizophr. Res. (IF 4.5) Pub Date : 2024-02-15 Andrew M. Chanen, Richard Kerslake, Felix-Antoine Berubé, Katie Nicol, Martina Jovev, Hok Pan Yuen, Jennifer K. Betts, Emma McDougall, Ai-Lan Nguyen, Marialuisa Cavelti, Michael Kaess
One in five young people with first-episode psychosis (FEP) also presents with borderline personality disorder (BPD) features. Among people diagnosed with BPD, auditory verbal hallucinations occur in 29–50 % and delusions in 10–100 %. Co-occurrence of psychotic symptoms and BPD is associated with greater clinical severity and greater difficulty accessing evidence based FEP care. This study aimed to
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Pre-emptive ice pack cryotherapy for reducing pain caused by long-acting deltoid injectable antipsychotic treatment: A single-center open-label study Schizophr. Res. (IF 4.5) Pub Date : 2024-02-15 Kohei Fujita, Yasuhiro Mori, Yu Kakumae, Nobuyuki Takeuchi, Kousuke Kanemoto, Makoto Nishihara
This empirical study aims to investigate the efficacy of pre-emptive cryotherapy in reducing pain that is caused by the deltoid intramuscular (IM) injection of long-acting injectable (LAI) antipsychotics in clinical settings. This study included 29 outpatients receiving LAI antipsychotic treatment. The evaluations of pain during (1) the usual procedure (control), (2) pre-emptive use of ice pack cryotherapy
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Inflammatory cerebrospinal fluid markers in schizophrenia spectrum disorders: A systematic review and meta-analysis of 69 studies with 5710 participants Schizophr. Res. (IF 4.5) Pub Date : 2024-02-15 Nicola Warren, Cullen O'Gorman, Isabelle Horgan, Milleni Weeratunga, Sean Halstead, Joanna Moussiopoulou, Mattia Campana, Vladislav Yakimov, Elias Wagner, Dan Siskind
There is increasing evidence of immune dysregulation and neuroinflammation occurring in schizophrenia. The aim of this study is to combine studies on routine CSF parameters, as well as cytokines and inflammatory proteins, in individuals with schizophrenia spectrum disorders. CSF parameters were summated and inverse variance meta-analyses using a random effects model were performed comparing mean difference
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Interpersonal distance in schizophrenia: A systematic review Schizophr. Res. (IF 4.5) Pub Date : 2024-02-15 Jakub Kraus, Natália Čavojská, Silvia Harvanová, Michal Hajdúk
Background and hypothesis: Schizophrenia is often associated with severe difficulties in social functioning, resulting in increased isolation and subsequent loneliness. Interpersonal distance – the amount of space around an individual's body during social interaction – can signal such difficulties. However, little is known about how individuals with schizophrenia regulate their interpersonal distance
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Pre-onset subthreshold psychotic symptoms are associated with differential treatment delays before a first episode of psychosis: Initial evidence and implications Schizophr. Res. (IF 4.5) Pub Date : 2024-02-09 S.V. McIlwaine, S. Mughal, M. Ferrari, R. Rosengard, A. Malla, S. Iyer, M. Lepage, R. Joober, J.L. Shah
Help-seeking and treatment delays are increasingly critical areas of study in mental health services. The duration of untreated psychosis (DUP), or the time between illness onset and initiation of treatment, is a predictor of symptom remission and functioning for a first episode of psychosis (FEP). The World Health Organization recommends that specialized treatment for psychosis be initiated within
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High rates of myocarditis with clozapine in the Hunter region of Australia Schizophr. Res. (IF 4.5) Pub Date : 2024-02-07 Srinivasan Tirupati, Mahinda K. Arachchi
To study the causes of clozapine treatment discontinuation and measure clozapine-induced myocarditis (CIM) rates in an Australian region, to compare the observed rates of CMI with reports from Australia and the world, and discuss factors related to CIM incidence rates in the region. The study is a retrospective clinical audit of 327 patients prescribed clozapine. All patients were monitored by the
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Medical cannabis authorization and risk of emergency department visits and hospitalization due to psychotic disorders: A propensity score-matched cohort study Schizophr. Res. (IF 4.5) Pub Date : 2024-02-07 Cerina Dubois, Carlotta Lunghi, Dean T. Eurich, Jason R.B. Dyck, Elaine Hyshka, John G. Hanlon, Arsene Zongo
Despite evidence showing that recreational cannabis use is associated with a higher risk of psychotic disorders, this risk has not been well characterized for patients using medical cannabis. Therefore, this study assessed the risk of emergency department (ED) visits and hospitalization for psychotic disorders (the study outcome) among adult patients authorized to use medical cannabis. We performed
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Characteristics of incident substance-induced psychosis compared to first-episode psychotic disorders: A nationwide register-linkage study from Sweden Schizophr. Res. (IF 4.5) Pub Date : 2024-02-06 Jeyaniroshan Jeyapalan, Pihla Sassi, Ellenor Mittendorfer Rutz, Jari Tiihonen, Heidi Taipale, Solja Niemelä
There is no previous research comparing preceding characteristics between incident substance-induced psychosis (SIP) and first-episode psychotic disorders (FEPD). To compare work-related factors and psychiatric morbidity preceding the incident psychotic episode between persons with SIP to persons with FEPD (ICD-10 F20–F29). Incident SIP aged 16–65 years (n = 7320, 79.4 % male) were identified from
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Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling Schizophr. Res. (IF 4.5) Pub Date : 2024-01-29 Csongor Tordai, Edit Hathy, Hella Gyergyák, Katalin Vincze, Máté Baradits, Júlia Koller, Ádám Póti, Bálint Jezsó, László Homolya, Mária Judit Molnár, László Nagy, Dávid Szüts, Ágota Apáti, János M. Réthelyi
Background Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly understood etiology, associated with both genetic and environmental factors. De novo mutations (DNMs) represent a new source of genetic variation in SCZ, however, in most cases their biological significance remains unclear. We sought to investigate molecular disease pathways connected to DNMs in SCZ by combining
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A systematic review of clozapine for aggression and violence in patients with schizophrenia or schizoaffective disorder Schizophr. Res. (IF 4.5) Pub Date : 2024-01-30 Justin Faden, Leslie Citrome
Although uncommon, the risk of aggression and violence is greater in people with schizophrenia than in the general population. Clozapine is the “gold standard” pharmacologic treatment for the management of persistent agitation and aggression in people with schizophrenia and is consistently recommended by guidelines and reviews for this purpose. Although clozapine is indicated for treatment-resistant
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Clozapine in treatment-resistant schizophrenia: Reflections from the Hallmark US clinical trial and beyond Schizophr. Res. (IF 4.5) Pub Date : 2024-01-29 John M. Kane, Georgios Schoretsanitis, Jose M. Rubio, Christoph U. Correll
Abstract not available
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Does college education reduce the risk of schizophrenia? Evidence from a college enrollment expansion policy in China Schizophr. Res. (IF 4.5) Pub Date : 2024-01-30 Yanshang Wang, Ruoxi Ding, Yanan Luo, Ping He, Xiaoying Zheng
Background Schizophrenia occurs worldwide, and the health, and economic burden is substantial. As one of the common proxies of socioeconomic status (SES), education was reported to be associated with the risk of developing schizophrenia. However, there is no causal evidence about the relationship. This paper explores the health benefits of college education for schizophrenia. Method Based on exogenous
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Effectiveness of a mindfulness-based intervention for persons with early psychosis: A multi-site randomized controlled trial Schizophr. Res. (IF 4.5) Pub Date : 2024-01-29 Arlene G. MacDougall, Joshua C. Wiener, Klajdi Puka, Elizabeth Price, Oluwatoni Oyewole-Eletu, Elmar Gardizi, Kelly K. Anderson, Ross M.G. Norman
Background The Mindfulness Ambassador Program (MAP) is a group-based, facilitated mindfulness-based intervention (MBI). We sought to determine the effectiveness of MAP on reducing negative psychotic symptoms and enhancing mindfulness skills among persons experiencing early psychosis. Methods We conducted a pragmatic randomized controlled trial (RCT) at three early psychosis intervention (EPI) programs
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Impaired perception of a partner's synchronizing behavior reduces positive attitude toward humanoid robot in schizophrenia patients Schizophr. Res. (IF 4.5) Pub Date : 2024-01-29 Juliette Lozano-Goupil, Ludovic Marin, Lise Aubin, Amandine Decombe, Hélène Serré, Delphine Capdevielle, Ghilès Mostafaoui, Stéphane Raffard
As interpersonal synchrony plays a key role in building rapport, the perception of another agent's synchronizing behavior could be an important feature to assess, especially with patients with social deficits such as in schizophrenia. Twenty-four schizophrenia patients and twenty-four matched healthy controls performed jointly fitness movements with another agent embodied by a humanoid robot which
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Toward non-stigmatizing media and language in mental health: Addressing the social stigma of schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-01-26 Karina Escandón
Abstract not available
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Symptom contributors to quality of life in schizophrenia: Exploratory factor and network analyses Schizophr. Res. (IF 4.5) Pub Date : 2024-01-28 Samuel M. Murphy, Ana T. Flores, Jessica A. Wojtalik, Matcheri S. Keshavan, Shaun M. Eack
Individuals with schizophrenia and other associated disorders experience significant disturbance to their quality of life (QoL) due to a multitude of co-occurring symptoms. Popular evidence-based practices (EBPs) devote significant effort to reduce positive symptomatology in order to prevent relapse, while emerging research posits that other symptoms (cognitive deficits, negative and affective symptoms)
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Safety of BEN guidelines in clozapine treatment: A Canadian perspective Schizophr. Res. (IF 4.5) Pub Date : 2024-01-22 Sally Wu, Valerie Powell, Araba Chintoh, Mohammed Alarabi, Sri Mahavir Agarwal, Gary Remington
Objective Unidentified benign ethnic neutropenia (BEN) has been recognized as a factor contributing to clozapine underutilization and discontinuation. Guidelines were implemented to accommodate BEN in Canada, and our main objective was to evaluate clozapine's safety in a sample of Canadian psychiatric patients with BEN. Method A retrospective chart review was conducted at the Centre for Addiction and
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The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction Schizophr. Res. (IF 4.5) Pub Date : 2024-01-23 Hadar Hazan, Maria Ferrara, Sarah Riley, Fangyong Li, Bin Zhou, Emily Kline, Toni Gibbs-Dean, Sneha Karmani, Sümeyra N. Tayfur, Cenk Tek, Matcheri Keshavan, Vinod Srihari
We examined the effects of an early detection (ED) campaign (Mindmap), that successfully shortened the duration of untreated psychosis (DUP), on patient presentation profiles at two receiving coordinated specialty care (CSC) services. Data were collected between 2015 and 2019 during a test of ED delivered at one CSC (STEP, n = 147) compared to usual detection at another CSC (PREP, n = 63). Regression
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Examining the effects of diagnostic awareness, positive symptoms, and negative symptoms on stigmatizing attitudes and social exclusion towards schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-01-25 Saleena A. Zedan, Aqsa Zahid, Michael W. Best
Background Social exclusion towards schizophrenia can occur as a response to symptom presentations and/or diagnostic knowledge. The present study examined stigma towards schizophrenia as a function of diagnostic awareness, positive symptoms, and negative symptoms. Methods 559 participants were presented with one of eight vignettes depicting an individual in a social situation based on a 2 (label: present
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Why and how might yoga differ from other mind-body approaches in schizophrenia? Schizophr. Res. (IF 4.5) Pub Date : 2024-01-25 Hemant Bhargav, Matcheri Keshavan
Abstract not available
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Social victimization, default mode network connectivity, and psychotic-like experiences in adolescents Schizophr. Res. (IF 4.5) Pub Date : 2024-01-23 Abhishek Saxena, Shangzan Liu, Elizabeth D. Handley, David Dodell-Feder
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Glutamate and GABA levels in the anterior cingulate cortex in treatment resistant first episode psychosis patients Schizophr. Res. (IF 4.5) Pub Date : 2024-01-25 Marieke van der Pluijm, Maartje Alting, Anouk Schrantee, Richard A.E. Edden, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giessen
Background Around 30 % of schizophrenia patients do not respond sufficiently to conventional antipsychotic treatment. Glutamate and γ-aminobutyric acid (GABA) may be implicated in treatment resistant (TR) patients. Some data indicate that TR patients show increased glutamate levels compared to responders, but findings are inconclusive and limited in the early disease stage. Furthermore, the two neurotransmitters
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Not socially blind: Unimpaired perception of social interaction in schizophrenia Schizophr. Res. (IF 4.5) Pub Date : 2024-01-22 Huiying Liu, Enze Tang, Chenxiao Guan, Jian Li, Jiewei Zheng, Dongsheng Zhou, Mowei Shen, Hui Chen
Abstract not available
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An SMS text messaging intervention to improve clinical engagement in early psychosis: A pilot randomized-controlled trial Schizophr. Res. (IF 4.5) Pub Date : 2024-01-18 Jessica N. D'Arcey, Haoyu Zhao, Wei Wang, Aristotle N. Voineskos, Nicole Kozloff, Sean A. Kidd, George Foussias
Disengagement of youth with psychosis from Early Psychosis Intervention (EPI) services continues to be a significant barrier to recovery, with approximately one-third prematurely discontinuing treatment despite the ongoing need. The current pilot trial sought to evaluate the preliminary efficacy and feasibility of a weekly short message service (SMS) intervention to improve engagement in EPI services
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Evidence for the factor structure of formal thought disorder: A systematic review Schizophr. Res. (IF 4.5) Pub Date : 2024-01-19 Georgia Zamperoni, Eric J. Tan, Susan L. Rossell, Denny Meyer, Philip J. Sumner
Disorganised speech, or, formal thought disorder (FTD), is considered one of the core features of psychosis, yet its factor structure remains debated. This systematic review aimed to identify the core dimensions of FTD. In line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), a systematic review was conducted on the FTD factor analytic literature. Sixteen studies
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Does affect mediate the relationship between interpersonal trauma and psychosis? A systematic review and meta-analysis Schizophr. Res. (IF 4.5) Pub Date : 2024-01-20 Shelley Grady, Conal Twomey, Clare Cullen, Keith Gaynor
Introduction The relationship between interpersonal trauma and psychosis is well established, and research is now focused on identifying mechanisms that may explain this relationship. Models of trauma and psychosis increasingly emphasize a broad range of affective processes, yet the overall effect of these affective processes is not well understood. Aim This review systematically examined the effect
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The effect of anticholinergic burden of psychiatric medications on major outcome domains of psychotic disorders: A 21-year prospective cohort study Schizophr. Res. (IF 4.5) Pub Date : 2024-01-18 Victor Peralta, Elena García de Jalón, Lucía Moreno-Izco, David Peralta, Lucía Janda, Ana M. Sánchez-Torres, Manuel J. Cuesta
Background Most medications used to treat psychotic disorders possess anticholinergic properties. This may result in a considerable anticholinergic burden (ACB), which may have deleterious effects on long-term outcomes. The extent to which cumulative ACB over years of treatment with psychotropic medications impacts different outcome domains remains unknown. Methods This was a naturalistic study of
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Ethics in placebo-controlled, acute treatment trials in schizophrenia: Two rival ethical frameworks Schizophr. Res. (IF 4.5) Pub Date : 2024-01-17 Ryan E. Lawrence, Paul S. Appelbaum
Placebo-controlled, acute treatment trials in schizophrenia enroll acutely symptomatic persons, randomize them to receive placebo or antipsychotic medication for several weeks, and evaluate whether symptoms improve. These trials can have scientific benefits, especially when they test drugs with novel mechanisms of action. However, the use of placebo is ethically problematic inasmuch as standard treatment
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Self-monitoring deficits in schizophrenia: A cross-sectional study of the underlying cognitive mechanisms Schizophr. Res. (IF 4.5) Pub Date : 2024-01-17 Rachid Ghieh, Martyna Krężołek, Łukasz Gawęda
Background People diagnosed with schizophrenia share underlying cognitive deficits in self-monitoring (i.e., identifying the source of self-generated behaviours). This study aimed to investigate whether self-monitoring deficits in schizophrenia are due to a cognitive response bias towards external perceptions or a reduced discriminability of imagined and performed actions. We hypothesised that self-monitoring
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Investigation on the association between perceived family expressed emotion, self-stigma, and subjective quality of life in people with early psychosis in Hong Kong: A cross-sectional approach Schizophr. Res. (IF 4.5) Pub Date : 2024-01-18 Bernice H.M. Ng, Ben C.L. Yu, Joey S.Y. Leung
Abstract not available
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Poor sleep quality in schizophrenia patients: A systematic review and meta-analyses of epidemiological and case-control studies Schizophr. Res. (IF 4.5) Pub Date : 2024-01-18 Meng-Yi Chen, Yue-Ying Wang, Tong Leong Si, Yu-Fei Liu, Zhaohui Su, Teris Cheung, Gabor S. Ungvari, Todd Jackson, Qinge Zhang, Yu-Tao Xiang
Objective Poor sleep quality is common in patients with schizophrenia but estimated prevalence rates in this population have been mixed. This systematic review and meta-analysis examined the prevalence of poor sleep quality in schizophrenia samples and moderators of prevalence from epidemiological studies as well as the risk of poor sleep quality in schizophrenia patients based on case-control studies