样式: 排序: IF: - GO 导出 标记为已读
-
Differences in the relation of binge drinking and prescription drug misuse to suicide ideation and attempts between college-aged adults and adults above the age of 25: Findings from the 2015–2019 National Survey on Drug Use and Health (NSDUH) J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-11 Andrew C. Porter, Kristiana D. Carrasquillo, Lisham Ashrafioun
To clarify the role of age in risk associated with drug misuse and binge drinking, this study examines the differential relations of binge drinking and prescription drug misuse to risk of suicidal ideation and attempts in young adults of college age (18–24) compared to those above the age of 25. We used data from the National Survey on Drug Use and Health (NSDUH) for the years 2015 through 2019 (N = 269
-
Characterizing the hierarchical depression phenotype in sexually diverse individuals J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-11 Jenna C. Alley, Daniel P. Moriarity, Matthew B. Figueroa, George M. Slavich
Sexual diverse individuals are at high risk for internalizing psychopathologies, such as depression. Understanding how symptom profiles of heterogeneous psychiatric disorders such as depression differ for sexually diverse vs. heterosexual individuals is thus critical to advance precision psychiatry and maximize our ability to effectively treat members of this population. Research has failed to consider
-
Lower odds of successful community discharge after medical hospitalization for Veterans with schizophrenia: A retrospective cohort study of national data J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-11 Julia Browne, Wen-Chih Wu, Lan Jiang, Mriganka Singh, Melanie L. Bozzay, Zachary J. Kunicki, Thomas A. Bayer, Alyssa N. De Vito, Jennifer M. Primack, John E. McGeary, Catherine M. Kelso, James L. Rudolph
Medical comorbidity, particularly cardiovascular diseases, contributes to high rates of hospital admission and early mortality in people with schizophrenia. The 30 days following hospital discharge represents a critical period for mitigating adverse outcomes. This study examined the odds of successful community discharge among Veterans with schizophrenia compared to those with major affective disorders
-
Impact of PTSD treatment on postconcussive ymptoms in veterans: A comparison of sertraline, prolonged exposure, and their combination J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-08 Katherine E. Porter, Murray B. Stein, Peter P. Grau, H. Myra Kim, Corey Powell, Charles W. Hoge, Margaret R. Venners, Erin R. Smith, Brian Martis, Naomi M. Simon, Israel Liberzon, Sheila A.M. Rauch, the PROGrESS Research Team
Many Veterans who served in Iraq and Afghanistan struggle with posttraumatic stress disorder (PTSD) and the effects of traumatic brain injuries (TBI). Some people with a history of TBI report a constellation of somatic, cognitive, and emotional complaints that are often referred to as postconcussive symptoms (PCS). Research suggests these symptoms may not be specific to TBI. This study examined the
-
PTSD, depression, and treatment outcomes: A latent profile analysis among active duty personnel in a residential PTSD program J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-08 Alexander C. Kline, Nicholas Otis, Kaitlyn E. Panza, Cameron T. McCabe, Lisa Glassman, Justin S. Campbell, Kristen H. Walter
Depression frequently co-occurs with posttraumatic stress disorder (PTSD), including among active duty service members. However, symptom heterogeneity of this comorbidity is complex and its association with treatment outcomes is poorly understood, particularly among active duty service members in residential treatment. This study used latent profile analysis (LPA) to identify symptom-based subgroups
-
A meta-analysis of transcranial magnetic stimulation in Tourette syndrome J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-08 Elizabeth R. Steuber, Joseph F. McGuire
There is growing enthusiasm for the treatment of neuropsychiatric disorders using neuromodulation. While some reports claim that transcranial magnetic stimulation (TMS) can be used to treat Tourette Syndrome (TS), little research exists to support this assertion. This meta-analysis examined the efficacy of TMS to reduce tic severity in patients with TS. Additionally, it explored the effect of TMS to
-
Association between degree centrality and neurocognitive impairments in patients with schizophrenia: A longitudinal rs-fMRI study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-05 Shixuan Feng, Yuanyuan Huang, Hehua Li, Sumiao Zhou, Yangdong Feng, Yuping Ning, Wei Han, Qing hang, Ziyun Zhang, Chenyu Liu, Junhao Li, Xitong Wen, Kai Wu, Fengchun Wu
Evidence indicates that patients with schizophrenia (SZ) experience significant changes in their functional connectivity during antipsychotic treatment. Despite previous reports of changes in brain network degree centrality (DC) in patients with schizophrenia, the relationship between brain DC changes and neurocognitive improvement in patients with SZ after antipsychotic treatment remains elusive.
-
Reduced sleep quality defines a subtype of obsessive-compulsive disorder with lower Glx levels in the resting thalamus and worse response inhibition J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-05 Jian Wang, Cigui Huang, Guowei Luo, Yuqing Xiao, Guangquan Guo, Dongming Quan, Huirong Zheng
The aim of this study was to investigate the differences between resting and active thalamic neurometabolite levels and inhibitory function in obsessive compulsive disorder (OCD) patients with poor sleep quality (PSQ was defined as Pittsburgh Sleep Quality Index >5 and sleep efficiency ≤85%) compared to OCD patients with good sleep quality (GSQ) and healthy controls (HCs), as well as the relationship
-
Oral prolonged-release ketamine in treatment-resistant depression - A double-blind randomized placebo-controlled multicentre trial of KET01, a novel ketamine formulation – Clinical and safety results J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-04 M. Colla, B. Offenhammer, H. Scheerer, G. Kronenberg, S. Vetter, J. Mutschler, T. Mikoteit, A. Bankwitz, A. Adank, L. Schaekel, C. Eicher, A.B. Bruehl, E. Seifritz
We investigated the antidepressant effects of a novel oral prolonged-release formulation of racemic ketamine (KET01) in patients suffering from treatment-resistant depression (TRD) as add-on therapy. Patients were randomized to an additional 160 mg/day or 240 mg/day KET01 or placebo for 14 days. The primary endpoint was change in Montgomery-Åsberg Depression Rating Scale (MADRS) scores from baseline
-
The relationship of neuropsychiatric symptoms with inflammatory markers in the hippocampus and cingulate cortex of bipolar disorder subjects: A post-mortem study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-02 Camila Nascimento, Paula Villela Nunes, Renata Elaine Paraizo Leite, Lea Tenenholz Grinberg, Claudia Kimie Suemoto, Beny Lafer
Increased levels of inflammation markers have been found in the peripheral tissue of individuals with bipolar disorder (BD), especially during mood episodes. Previous studies found distinctive inflammatory profiles across different brain regions, but potential associations with clinical symptoms are still lacking. This study aims to evaluate the association of neuropsychiatric symptoms with inflammatory
-
Associations between somatic symptoms and remission of major depressive disorder: A longitudinal study in China J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-29 Yingchen Jiang, Dongjian Zhu, Xinyu Huang, Yanzhi Li, Ya Chen, Yunbin Jiang, Wanxin Wang, Lan Guo, Yan Chen, Yuhua Liao, Yifeng Liu, Huimin Zhang, Gia Han Le, Roger S. McIntyre, Beifang Fan, Ciyong Lu
Previous studies have documented negative associations between somatic symptoms and remission of major depressive disorder (MDD). However, the correlations of specific somatic symptoms with remission remain uncertain. We aimed to explore the associations between specific somatic symptoms and remission focusing on sex differences among patients with MDD. We used data from patients with MDD in the Depression
-
The volume of gray matter mediates the relationship between glucolipid metabolism and neurocognition in first-episode, drug-naïve patients with schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-29 Hai-ling Cao, Ya-jing Meng, Ya-min Zhang, Wei Deng, Wan-jun Guo, Ming-li Li, Tao Li
We aimed to examine the hypotheses that glucolipid metabolism is linked to neurocognition and gray matter volume (GMV) and that GMV mediates the association of glucolipid metabolism with neurocognition in first-episode, drug-naïve (FEDN) patients with schizophrenia. Parameters of glucolipid metabolism, neurocognition, and magnetic resonance imaging were assessed in 63 patients and 31 controls. Compared
-
Duration of daily life activities in persons with and without obsessive–compulsive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-28 Eva M. Zisler, Adrian Meule, Stefan Koch, Rebecca Schennach, Ulrich Voderholzer
Persons with obsessive–compulsive disorder (OCD) are often impaired in their daily level of functioning due to their time-consuming obsessions and/or compulsions. To date, however, studies are lacking that quantify how much time persons with OCD actually spend on activities of daily living. Therefore, the current study assessed 13 daily life activities (in minutes) with a self-report questionnaire
-
The prevalence of cannabis use disorder in attention-deficit hyperactivity disorder: A clinical epidemiological meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-28 Anna M. Froude, Emily J. Fawcett, Ashlee Coles, Dalainey H. Drakes, Nick Harris, Jonathan M. Fawcett
Studies have shown that individuals with attention-deficit hyperactivity disorder (ADHD) pose an increased risk for developing substance use disorders. Increased cannabis product accessibility and recent legislative changes have led to increased cannabis consumption, thereby increasing the risk of cannabis use disorder (CUD). The present meta-analysis explored the lifetime and current prevalence of
-
The role of referral pathway to early intervention services for psychosis on 2-year inpatient and emergency service use J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-28 Brannon Senger, Alissa Pencer, Candice E. Crocker, Patryk Simon, Bryanne Taylor, Philip G. Tibbo
This study examined the relationship between terminal referral source and subsequent urgent health service use in a Canadian early intervention service (EIS) for psychosis. Administrative health record data of emergency and inpatient mental health service use over a 2-year follow up from entry to EIS were retrospectively analyzed (n = 515). Negative binomial regression models were used to assess for
-
Influence of affective instability on suicidal ideation beyond traumatic brain injury and posttraumatic stress disorder in veterans J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-28 Brandy S. Martinez, Jared A. Rowland, Robert D. Shura, Anna T. Magnante, Rajendra A. Morey, Sarah L. Martindale
Mild traumatic brain injury (TBI) is associated with long-term consequences, including greater risk for posttraumatic stress disorder (PTSD) and suicidal ideation. Affective instability is also independently related to PTSD and suicidality, which may explain why some individuals continue to experience chronic psychiatric complaints following mild TBI. The purpose of the present study was to evaluate
-
Brain derived neurotrophic factor and treatment outcomes among veterans attending an intensive treatment program for posttraumatic stress disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-27 Alyson K. Zalta, Robin M. Voigt, Sarah K. Stevens, Philip Held, Shohreh Raeisi, Randy A. Boley, Ali Keshavarzian, Mark H. Pollack
Brain derived neurotrophic factor (BDNF) may play an important role in the success of treatment for posttraumatic stress disorder (PTSD). Pre- and post-treatment blood samples were analyzed for 40 veterans who completed a 3-week intensive outpatient treatment for PTSD. The treatment included Cognitive Processing Therapy, mindfulness, and yoga as core treatment components. PTSD symptoms were assessed
-
Mental health outcomes and suicidality in hospitalized transgender adolescents: A propensity score-matched Cross-sectional analysis of the National inpatient sample 2016–2018 J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-27 Chintan Trivedi, Abid Rizvi, Zeeshan Mansuri, Shailesh Jain
Transgender adolescents have unique mental health needs. This demographic has increased rates of mood disorders, anxiety, and depression compared to their cisgender peers. Large-scale studies focused on mental health outcomes, including suicidality, in the transgender adolescent population remain unknown. This study tries to fill these gaps in the literature.
-
The role of orexin receptors within the CA1 area in the acquisition and expression of methamphetamine place preference J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-26 Fazel Moshrefi, Amir Mohammad Farrokhi, Mojdeh Fattahi, Ronak Azizbeigi, Abbas Haghparast
Treatment of Methamphetamine (METH) use disorder has become a crucial public health issue. The orexin system manipulation has provided promising evidence to attenuate addictive-like behaviors. This study explored the role of the orexin 1 receptor and orexin 2 receptor (OX1R and OX2R) in the CA1 area of the hippocampal formation in the acquisition and expression of METH-induced place preference. Animals
-
Differential associations of adverse childhood experiences and mental health outcomes in U.S. military veterans J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-26 Alana Z. Slavin, Ian C. Fischer, Robert H. Pietrzak
Adverse childhood experiences (ACEs) are robustly associated with adverse mental health outcomes across the lifespan. Military veterans may be particularly vulnerable to adverse mental health effects of ACEs given their potentially higher prevalence of childhood traumas and compounding effects of military service-related traumas. To date, however, scarce research has examined the differential impact
-
Neural correlates of cognitive behavioral therapy-based interventions for bipolar disorder: A scoping review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-26 Francesca Girelli, Maria Gloria Rossetti, Cinzia Perlini, Marcella Bellani
Cognitive Behavioral Therapy (CBT) is among the gold-standard psychotherapeutic interventions for the treatment of psychiatric disorders, including bipolar disorder (BD). While the clinical response of CBT in patients with BD has been widely investigated, its neural correlates remain poorly explored. Therefore, this scoping review aimed to discuss neuroimaging studies on CBT-based interventions in
-
Abnormal prefrontal cortical activation during the GO/NOGO and verbal fluency tasks in adult patients with comorbid generalized anxiety disorder and attention-deficit/hyperactivity disorder: An fNIRS study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-26 Yuchen Zhang, Yaju Feng, Linfeng Liu, Guoqing Jiang, Minjian Wang
Generalized anxiety disorder (GAD) and adult attention-deficit/hyperactivity disorder (ADHD) are commonly reported comorbidities. Adult GAD patients with comorbid ADHD are often underdiagnosed and undertreated. To explore the clinical value of functional near-infrared spectroscopy (fNIRS) data for assisting in the accurate diagnosis of ADHD in individuals with GAD, haemoglobin (HbO) concentration changes
-
Can clinical and subclinical forms of narcissism be considered risk factors for suicide-related outcomes? A systematic review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-24 Veronica Sprio, Lucia Mirra, Fabio Madeddu, Jorge Lopez-Castroman, Hilario Blasco-Fontecilla, Rossella Di Pierro, Raffaella Calati
Clinical and subclinical forms of narcissism may increase suicide risk. However, little is known and there are controversies on this topic. This systematic review aims at providing an overview of studies investigating this association. We used PubMed, Scopus, and PsycInfo databases and followed PRISMA. We focused on cohort, case-control, cross-sectional and case series studies. We referred to both
-
Corrigendum to “Impaired socio-affective, but intact socio-cognitive skills in patients with treatment-resistant, recurrent depression” [J. Psychiatr. Res. 153 (2022) 206-212 / https://doi.org/10.1016/j.jpsychires.2022.07.025] J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-23 Hannah M. Kilian, Bastian Schiller, Thomas E. Schläpfer, Markus Heinrichs
-
Corrigendum to: “Is pain empathy associated with pain indices and trauma history? A comparison between patients receiving methadone maintenance treatment and healthy controls” [J. Psychiatr. Res. 171 (2024) 286–295 37] J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-23 Shlomit Zorani, Einat Peles
-
Reduced pre-attentive threat versus nonthreat signal discrimination in clinically healthy military personnel with recurrent combat exposure history: A preliminary event-related potential (ERP) study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-23 Andrew J. Lawrence, Ellie Lawrence-Wood, Eugene V. Aidman, Phaedra L. Spencer-Merris, Kim L. Felmingham, Alexander C. McFarlane
Evidence now suggests that traumatic-stress impacts brain functions even in the absence of acute-onset post-traumatic stress disorder (PTSD) symptoms. These neurophysiological changes have also been suggested to account for increased risks of PTSD symptoms later developing in the aftermath of subsequent trauma. However, surprisingly few studies have explicitly examined brain function dynamics in high-risk
-
-
Burden of depressive disorders in Vietnam from 1990 to 2019: A secondary analysis of the Global Burden of Disease Study 2019 J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-22 Quynh Thi Vu, Ko Harada, Yoshito Nishimura, Hideharu Hagiya, Elizabeth Tan, Odifentse Mapula E. Lehasa, Yoshito Zamami, Toshihiro Koyama
Depressive disorders are among the leading causes of disability globally. However, information on the burden of depressive disorders in Vietnam is limited. We aimed to analyse the burden of depressive disorders in Vietnam from 1990 to 2019. Using data from the Global Burden of Disease Study 2019, prevalence and disability-adjusted life-years (DALYs) were used as indicators to analyse the burden of
-
Human transcriptome array analysis and diffusion tensor imaging in attention-deficit/hyperactivity disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Liang-Jen Wang, Sung-Chou Li, Wen-Jiun Chou, Ho-Chang Kuo, Sheng-Yu Lee, Wei-Che Lin
The mRNA markers identified using microarray assay and diffusion tensor magnetic resonance imaging (DTI) were applied to elucidate the pathophysiology of attention-deficit hyperactivity disorder (ADHD). First, we obtained total RNA from leukocytes from three children with ADHD and three healthy controls for analysis with microarray assays. Subsequently, we applied real-time quantitative polymerase
-
Worldwide prevalence of obsessive-compulsive symptoms during the COVID-19 pandemic: A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Andrea Pozza, Federica Ragucci, Nicole Loren Angelo, Daniele Pugi, Alessandro Cuomo, Maria Dolores Garcia-Hernandez, Ana Isabel Rosa-Alcazar, Andrea Fagiolini, Vladan Starcevic
-
Association between neutrophil to lymphocyte ratio and inflammatory biomarkers in patients with a first episode of psychosis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Miquel Bioque, Vicent Llorca-Bofí, Sergi Salmerón, Borja García-Bueno, Karina S. MacDowell, Carmen Moreno, Pilar A. Sáiz, Ana González-Pinto, María Hidalgo-Figueroa, María Fe Barcones, Roberto Rodriguez-Jimenez, Miquel Bernardo, Juan Carlos Leza
-
Abnormal amplitude of low-frequency fluctuations associated with sleep efficiency in major depressive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Yifei Li, Wenming Zhao, Xinyu Li, Lianzi Guan, Yu Zhang, Jiakuai Yu, Jiajia Zhu, Dao-min Zhu
Sleep disturbance is one of the most frequent somatic symptoms in major depressive disorder (MDD), but the neural mechanisms behind it are not well understood. Sleep efficiency (SE) is a good indicator of early awakening and difficulty falling asleep in MDD patients. Our study aimed to investigate the relationship between sleep efficiency and brain function in MDD patients. We recruited 131 MDD patients
-
Correlation of potential diagnostic biomarkers (circulating miRNA and protein) of bipolar II disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Kuo-Wang Tsai, Yi-Fang Yang, Liang-Jen Wang, Chih-Chuan Pan, Cheng-Ho Chang, Yung-Chih Chiang, Tzu-Yun Wang, Ru-Band Lu, Sheng-Yu Lee
We previously identified certain peripheral biomarkers of bipolar II disorder (BD-II) including circulating miRNAs (miR-7-5p, miR-142–3p, miR-221–5p, and miR-370–3p) and proteins (Matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)). We try to explore the
-
Clinical and neuroimaging predictors of benzodiazepine response in catatonia: A machine learning approach J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Jane Badinier, Renaud Lopes, Tomas Mastellari, Thomas Fovet, Steven C.R. Williams, Jean-Pierre Pruvo, Ali Amad
-
Prefrontal cortical synaptoproteome profile combined with machine learning predicts resilience towards chronic social isolation in rats J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-21 Dragana Filipović, Božidar Novak, Jinqiu Xiao, Predrag Tadić, Christoph W. Turck
Chronic social isolation (CSIS) of rats serves as an animal model of depression and generates CSIS-resilient and CSIS-susceptible phenotypes. We aimed to investigate the prefrontal cortical synaptoproteome profile of CSIS-resilient, CSIS-susceptible, and control rats to delineate biochemical pathways and predictive biomarker proteins characteristic for the resilient phenotype. A sucrose preference
-
Cerebrolysin potentiates the antidepressant effect of lithium in a rat model of depression J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-17 Ahmed O. Abdelaty, Engy K. Tharwat, Alaa I. Abdelrahman, Ayatallah Elgohary, Hebatallah Elsaeed, Amena S. El-Feky, Yasmina M. Ebrahim, Abdelaziz Habib, Hasnaa Abd El Latif, Yasser A. Khadrawy, Heba S. Aboul Ezz, Neveen A. Noor, Heba M. Fahmy, Faten F. Mohammed, Nasr M. Radwan, Nawal A. Ahmed
Depression is the most prevalent psychiatric disorder worldwide. Although numerous antidepressant treatments are available, there is a serious clinical concern due to their severe side effects and the fact that some depressed patients are resistant to them. Lithium is the drug of choice for bipolar depression and has been used as adjunct therapy with other groups of antidepressants. The present study
-
Preliminary examination of ADHD inattentive and cognitive disengagement syndrome symptoms in relation to probe-caught mind-wandering during a sustained attention to response task J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-16 Kelsey K. Wiggs, Joseph W. Fredrick, Leanne Tamm, Jeffery N. Epstein, John O. Simon, Stephen P. Becker
The role of mind-wandering– periods of internally-directed distractibility – among patients with attention-deficit/hyperactivity disorder (ADHD) has recently garnered attention, though few studies have assessed mind-wandering using thought probes during a sustained attention to response task (SART) or examined the possible role of cognitive disengagement syndrome (CDS) symptoms. We examined whether
-
Multimodal integration of neuroimaging and genetic data for the diagnosis of mood disorders based on computer vision models J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-15 Seungeun Lee, Yongwon Cho, Yuyoung Ji, Minhyek Jeon, Aram Kim, Byung-Joo Ham, Yoonjung Yoonie Joo
Mood disorders, particularly major depressive disorder (MDD) and bipolar disorder (BD), are often underdiagnosed, leading to substantial morbidity. Harnessing the potential of emerging methodologies, we propose a novel multimodal fusion approach that integrates patient-oriented brain structural magnetic resonance imaging (sMRI) scans with DNA whole-exome sequencing (WES) data. Multimodal data fusion
-
Sedative drug prescription patterns in Danish adults from 2002 through 2021. A register-based cohort study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-15 Merete Osler, Thomas Wolff Rosenqvist, Ida Kim Wium-Andersen, Marie Kim Wium-Andersen, Mathilde Marie Brünnich Sloth, Emma Neble Larsen, Martin Balslev Jørgensen, Frederikke Hørdam Gronemann
Pharmacological treatment strategies for insomnia seem to vary, and there is lack of knowledge about how sedative drugs are used in a real-world setting. We investigated changes in sedative drug prescription patterns in Danish adults who initiated treatment between 2002 and 2016. All adults with a first-time purchase of a sedative drug registered in the Danish National Prescription Register from 2002
-
Longitudinal trajectories of psychosocial functioning in patients with pre-existing mental disorders after one year of COVID-19 pandemic J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-15 M. Luciano, C. Carmassi, G. Sampogna, C.A. Bertelloni, G. Abbate-Daga, U. Albert, G. Castellini, B. Della Rocca, S. Fantasia, M. Menchetti, V. Pedrinelli, M. Pompili, M.S. Signorelli, S. Tosato, PsyCOVID working group, Leonardo Massoni e Debora Andreoli, Francesca Maria Clesi, Vittoria Bastanzetti, Paola Longo, Matteo Panero, Sofia Burato, Alberto D'Aietti, Marco Faldi, Giorgia Marchesoni, Matteo Di
Aims of the present study were to prospectively assess psychosocial functioning trajectories during the COVID pandemic and the possible impact of sociodemographic variables, as well as of COVID-19 pandemic-related factors, on these trajectories, in a sample of patients with pre-existing severe mental disorders. Moreover, we aimed at identifying predictors of impairment in psychosocial functioning over
-
Sustained mental health and functional responses to the COVID-19 pandemic in Black and White Veterans with psychosis or recent homelessness J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-15 Derek M. Novacek, Jonathan K. Wynn, Amanda McCleery, Eric A. Reavis, Damla Senturk, Catherine A. Sugar, Jack Tsai, Michael F. Green
The COVID-19 pandemic disproportionately impacted marginalized populations including Black Americans, people with serious mental illness, and individuals experiencing homelessness. Although the double disadvantage hypothesis would suggest that individuals with multiple minoritized statuses would experience worse psychosocial impacts from the pandemic, this may not be the case for vulnerable Black Veterans
-
Distinguishing schizophrenia and bipolar disorder through a Multiclass Classification model based on multimodal neuroimaging data J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-15 Ming Chen, Xiaowei Xia, Zhuang Kang, Zhinan Li, Jiamin Dai, Junyan Wu, Cai Chen, Yong Qiu, Tong Liu, Yanxi Liu, Ziyi Zhang, Qingni Shen, Sichu Tao, Zixin Deng, Ying Lin, Qinling Wei
This study aimed to identify neural biomarkers for schizophrenia (SZ) and bipolar disorder (BP) by analyzing multimodal neuroimaging. Utilizing data from structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), and resting-state functional magnetic resonance imaging (rs-fMRI), multiclass classification models were created for SZ, BP, and healthy controls (HC). A total of 113 participants
-
Adverse childhood experiences differently affect Theory of Mind brain networks in schizophrenia and healthy controls J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-14 Benedetta Vai, Federico Calesella, Alice Pelucchi, Martina Riberto, Sara Poletti, Margherita Bechi, Roberto Cavallaro, Benedetti Francesco
Patients with schizophrenia (SZ) show impairments in both affective and cognitive dimensions of theory of mind (ToM). SZ are also particularly vulnerable to detrimental effect of adverse childhood experiences (ACE), influencing the overall course of the disorder and fostering poor social functioning. ACE associate with long-lasting detrimental effects on brain structure, function, and connectivity
-
Machine learning for prediction of schizophrenia based on identifying the primary and interaction effects of minor physical anomalies J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-14 Shuen-Lin Jeng, Ming-Jun Tu, Chih-Wei Lin, Jin-Jia Lin, Huai-Hsuan Tseng, Fong-Lin Jang, Ming-Kun Lu, Po-See Chen, Chih-Chun Huang, Wei-Hung Chang, Hung-Pin Tan, Sheng-Hsiang Lin
In the neurodevelopmental model of schizophrenia, minor physical anomalies (MPAs) are considered neurodevelopmental markers of schizophrenia. To date, there has been no research to evaluate the interaction between MPAs. Our study built and used a machine learning model to predict the risk of schizophrenia based on measurements of MPA items and to investigate the potential primary and interaction effects
-
Development and validation of the self-injury stigma scale J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-13 Caitlin M. O'Loughlin, Kenneth McClure, Brooke A. Ammerman
Non-suicidal self-injury is a prevalent and concerning behavior. Negative beliefs and stereotypes about NSSI are associated with negative outcomes, and negative, self-referential beliefs (e.g., self-stigmatizing beliefs) related to engagement in NSSI may be particularly harmful. Despite this, there is no validated measure specifically designed to assess for NSSI self-stigma. As this significantly hinders
-
Gastroesophageal reflux disease with 6 neurodegenerative and psychiatric disorders: Genetic correlations, causality, and potential molecular mechanisms J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-13 Zhi-Qing Zhan, Ze-Min Huang, Hao-Bin Zhou, Zhi-Xin Xie, Ying-Zhou Chen, Yu-Hua Luo, Pei-Zhen Chen, Jia-Qi Kang, Zhangkai J. Cheng, Baoqing Sun
The comorbidities between gastroesophageal reflux disease (GERD) and various neurodegenerative and psychiatric disorders have been widely reported. However, the genetic correlations, causal relationships, and underlying mechanisms linking GERD to these disorders remain largely unknown. Here, we conducted a bidirectional Mendelian randomization (MR) analysis to determine the causality between GERD and
-
Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-13 Yanfang Zhou, Leilei Wang, Kebing Yang, Junchao Huang, Yanli Li, Wei Li, Ping Zhang, Fengmei Fan, Yi Yin, Ting Yu, Song Chen, Xingguang Luo, Shuping Tan, Zhiren Wang, Wei Feng, Baopeng Tian, Li Tian, Chiang-Shan R. Li, Yunlong Tan
Stress plays an important role in the etiology of schizophrenia. However, the mechanisms by which chronic physiological stress and perceived stress relate to the clinical features of schizophrenia may differ. We aimed to elucidate the relationships among chronic physiological stress indexed by allostatic load (AL), perceived stress, and clinical symptoms in individuals with first-episode schizophrenia
-
ASD and ADHD: Divergent activating patterns of prefrontal cortex in executive function tasks? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-10 Yin Li, Shuai Ma, Xin Zhang, Lei Gao
The functional Near-infrared Spectroscopy (fNIRS) has been more and more widely used to measure the activation state of prefrontal cortex when performing function-related tasks among children with various developmental disorders. Children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) have shown obvious executive function defects. We aimed to summarize the studies
-
Neural differentiation of emotional faces as a function of interpersonal violence among adolescent girls J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-10 Amanda J.F. Tamman, Chadi G. Abdallah, Joseph E. Dunsmoor, Josh M. Cisler
Interpersonal violence (IV) is associated with altered neural threat processing and risk for psychiatric disorder. Representational similarity analysis (RSA) is a multivariate approach examining the extent to which differences between stimuli correspond to differences in multivoxel activation patterns to these stimuli within each ROI. Using RSA, we examine overlap in neural patterns between threat
-
Clinical and cognitive insight in panic disorder: phenomenology and treatment effects in internet cognitive behavior therapy J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-09 Asala Halaj, Asher Y. Strauss, Elad Zlotnick, Dina Zalaznik, Isaac Fradkin, Gerhard Andersson, David Daniel Ebert, Jonathan D. Huppert
Clinical observations suggest that individuals with panic disorder (PD) vary in their beliefs about the causes of their panic attacks. Some attribute these attacks to psychological factors, while others to physiological or medical factors. These beliefs also extend to whether individuals perceive panic attacks as dangerous. In other areas of psychiatric nosology, these phenomena are commonly called
-
Symptom clusters in adolescent depression and differential responses of clusters to pharmacologic treatment J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-09 Kyoung Min Kim, Kyung Hwa Lee, Haebin Kim, Ok Kim, Jae-Won Kim
Symptoms of depression in adolescents are widely variable, but they are often interactive and clustered. The analysis of interactions and clusters among individual symptoms may help predict treatment outcomes. We aimed to determine clusters of individual symptoms in adolescent depression and their changes in the response to pharmacological treatment. A total of 95 adolescents, aged 12–17 years, with
-
The effect of N-methyl-D-aspartate receptor antagonists on the mismatch negativity of event-related potentials and its regulatory factors: A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Xin Guo, Jieyang Yu, Chunhua Quan, Jinyu Xiao, Jiangtao Wang, Bo Zhang, Xiaosheng Hao, Xuemei Wu, Jianmin Liang
This study investigates the influence of N-methyl-D-aspartate receptor (NMDAR) antagonists on the mismatch negativity (MMN) components of event-related potentials (ERPs) in healthy subjects and explores whether NMDAR antagonists have different effects on MMN components under different types of antagonists, drug dosages, and deviant stimuli. We conducted a comprehensive literature search of PubMed,
-
Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Junru Guo, Li Wang, Xiaoqing Zhao, Dongmei Wang, Xiangyang Zhang
The relationship between suicide attempts and lipid profiles in patients with major depressive disorder (MDD) remains uncertain. The purpose of this study was to investigate sex differences in the relationship between suicide attempts and plasma lipid profiles in a large sample of first-episode and drug naive (FEDN) MDD patients. We recruited 1718 FEDN MDD patients and gathered demographic, clinical
-
Trends in burnout and related sick leave duration in working-age adults followed in general practices in Germany between 2012 and 2022 J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Karel Kostev, Stefanie Oswald, Ariel Frajerman, Josep Maria Haro, Louis Jacob
This study investigated burnout trends and related sick leave duration in working-age adults followed in general practices in Germany. Participants were aged 20–65 years and were diagnosed with burnout in one of 442 general practices in this country in 2012–2014, 2016–2018, and 2020–2022. The prevalence of burnout and the duration of sick leave in all practices were compared between 2012–2014 and 2016–2018
-
Bidirectional relationship between borderline personality features and depressive symptoms in early adolescence: A school-based cohort study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Shaojie Wang, Lulu Fang, Yuan Li, Leilei Cao, Gengfu Wang, Juan Chen, Puyu Su
Depressive symptoms is a public health concern worldwide, and adolescents may experience more depressive symptoms. Although the relationship between borderline personality features (BPFs) disorder and depressive symptoms has been established, it is unclear whether the longitudinal relationship between them is unidirectional or bidirectional and whether these symptoms are different between boys and
-
Specific mechanisms underlying executive and emotional apathy: A phenotyping study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Giulia Lafond-Brina, Bich-Thuy Pham, Anne Bonnefond
Apathy is a behavioral symptom prevalent both in neuropsychiatric pathologies and in the healthy population. However, the knowledge of the cognitive and neural mechanisms underlying apathy is still very limited, even if clinical and fMRI data support the existence of three forms of apathy (executive, emotional, initiative). These forms could be explained by the alteration of specific mechanisms. This
-
Sleep disturbances in primary aldosteronism are associated to depressive symptoms - Could specific mineralocorticoidreceptors be a common pathway? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Christian Adolf, Harald Murck, Anna-Lina Sarkis, Holger Schneider, Ina Fischer, Axel Steiger, Leah T. Braun, Martin Reincke, Heike Künzel
Symptoms of depression and anxiety are frequent in patients with primary aldosteronism (PA) and are supposed to be independent risk factors for cardiovascular diseases (CVD). As patients with PA have an increased cardiovascular risk compared to patients with essential hypertension, sleep disturbances, which often accompany depressive and anxiety symptoms, may be an additional contributor to the cardiometabolic
-
Adjunctive cariprazine as a novel effective strategy for treating major depressive disorder: A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Minjia Xie, Youjia Qiu, Menghan Wang, Xingzhou Wei, Yuchen Tao, Aojie Duan, Jing Shang, Wei Gao, Zhong Wang
Cariprazine has been approved by the Food and Drug Administration for treating bipolar depression and as an adjunctive treatment for Major Depressive Disorder (MDD). However, it remains unclear about its pharmacological efficacy in treating MDD. Therefore, a meta-analysis was conducted to investigate the adjunctive use of cariprazine in MDD. Electronic databases were searched for eligible studies evaluating
-
Cortical thickness of the posterior cingulate cortex is associated with the ketamine-induced altered sense of self: An ultra-high field MRI study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-02-08 Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic, Nils Opel, Alexander Refisch, Nikolai Blekic, Tamar Macharadze, Moritz Kretzschmar, MatthiasH.J. Munk, Christian Gaser, Oliver Speck, Martin Walter, Meng Li
Subanesthetic doses of ketamine induce an antidepressant effect within hours in individuals with treatment-resistant depression while it furthermore induces immediate but transient psychotomimetic effects. Among these psychotomimetic effects, an altered sense of self has specifically been associated with the antidepressant response to ketamine as well as psychedelics. However, there is plenty of variation
-