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Mood disorders in adults with epilepsy: a review of unrecognized facts and common misconceptions Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-03-04 Andres M. Kanner, Rohit Shankar, Nils G. Margraf, Bettina Schmitz, Elinor Ben-Menachem, Josemir W. Sander
Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive disturbances and psychiatric disorders. Prospective population-based studies have shown that people with epilepsy have an increased risk of developing mood disorders, and people with a primary mood disorder have an increased risk of developing epilepsy. The
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Impacts of metabolic disruption, body mass index and inflammation on cognitive function in post-COVID-19 condition: a randomized controlled trial on vortioxetine Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-02-29 Angela T.H. Kwan, Gia Han Le, Ziji Guo, Felicia Ceban, Kayla M. Teopiz, Taeho Greg Rhee, Roger Ho, Joshua D. Di Vincenzo, Sebastian Badulescu, Shakila Meshkat, Bing Cao, Joshua D. Rosenblat, Donovan A. Dev, Lee Phan, Mehala Subramaniapillai, Roger S. McIntyre
Post-COVID-19 Condition (PCC), as defined by the World Health Organization (WHO), currently lacks any regulatory-approved treatments and is characterized by persistent and debilitating cognitive impairment and mood symptoms. Additionally, metabolic dysfunction, chronic inflammation and the associated risks of elevated body mass index (BMI) have been reported. In this study, we aim to investigate the
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Causal links between sedentary behavior, physical activity, and psychiatric disorders: a Mendelian randomization study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-02-29 Hongjun Ba, Lili Zhang, Huimin Peng, Xiufang He, Yao Wang
Studies suggest a correlation between excessive sedentary behavior, insufficient physical activity, and an elevated likelihood of experiencing psychiatric disorder. Nonetheless, the precise influence of sedentary behavior and physical activity on psychiatric disorder remains uncertain. Hence, the objective of this research was to investigate the possible causal relationship between sedentary behavior
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Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-31 Jianan Li, Haoran Bi
Major depressive disorder (MDD) is predicted to become the second most common cause of disability in the near future. Exposure to glyphosate (Gly)-based herbicides has been linked to the onset of MDD. However, the underlying mechanisms remain unclear. The aim of this study was to investigate the potential molecular mechanisms of MDD induced by Gly using network toxicology approach. The MDD dataset
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Analyzing the psychometric properties of the PHQ-9 using item response theory in a Chinese adolescent population Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-23 Xuliang Gao, Ziyu Liu
People are more likely to fall victim to depression during adolescence since it is a period of rapid biopsychosocial transformation. Despite this, most depression research has concentrated on clinical issues, and evaluating depressive symptoms in teenagers is not as widespread. This study used item response theory (IRT) to examine the psychometric properties of the Patient Health Report scale (PHQ-9)
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On mental pain and suicide risk in modern psychiatry Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-16 Maurizio Pompili
Facing suicide risk is probably the most difficult task for clinicians when dealing with patients in crisis. It requires professional, intellectual, and emotional efforts. Suicide risk assessment can sometimes be distressing for clinicians, and such a state may favour the avoidance of an in-depth exploration of suicidal thoughts and behaviour. Patients often feel subjected to interpersonal assessments
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Predicting quetiapine dose in patients with depression using machine learning techniques based on real-world evidence Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-06 Yupei Hao, Jinyuan Zhang, Jing Yu, Ze Yu, Lin Yang, Xin Hao, Fei Gao, Chunhua Zhou
Being one of the most widespread, pervasive, and troublesome illnesses in the world, depression causes dysfunction in various spheres of individual and social life. Regrettably, despite obtaining evidence-based antidepressant medication, up to 70% of people are going to continue to experience troublesome symptoms. Quetiapine, as one of the most commonly prescribed antipsychotic medication worldwide
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Diagnostic value and role of serum miR-15a-5p in patients with schizophrenia Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-05 Zhen Xu, Ruidong Yang, Guanwen Chen, Mingjun Jiang
More and more studies have confirmed that the heredity plays an important role in mental disorders, especially microRNA. The objective of this research was to explore the level of miR-15a-5p in patients with schizophrenia (SZ), and to evaluate the feasibility of this miRNA as a diagnostic marker of SZ. The serum level of miR-15a-5p in patients with SZ and healthy people was detected by RT-qPCR. ROC
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Occurrences of post-traumatic stress disorder, anxiety, depression, and burnout syndrome in ICU staff workers after two-year of the COVID-19 pandemic: the international PSY-CO in ICU study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-03 Claire Roger, Lowel Ling, Mélissa Petrier, Loubna Elotmani, Enora Atchade, Bernard Allaouchiche, Frédéric Aubrun, Jean-Michel Constantin, Claire Dahyot-Fizelier, Nathalie Delhaye, Hervé Dupont, Marc-Olivier Fischer, Marc Garnier, Etienne Gayat, Carole Ichai, Samir Jaber, Jérome Morel, Benoit Plaud, Thomas Rimmelé, Sylvaine Robin, Renee Saba, Gavin M. Joynt, Jean-Yves Lefrant, Pascale Fabbro-Peray,
The present study aimed at assessing the prevalences of post-traumatic stress disorder (PTSD) (main objective), anxiety, depression, and burnout syndrome (BOS) and their associated factors in intensive care unit (ICU) staff workers in the second year of the COVID-19 pandemic. An international cross-sectional multicenter ICU-based online survey was carried out among the ICU staff workers in 20 ICUs
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Predictors of antipsychotics switching among ambulatory patients with schizophrenia in Ethiopia: a multicenter hospital-based cross-sectional study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-03 Mekdes Kiflu, Telake Azale, Kale Gubae, Samuel Agegnew Wondm, Ephrem Mebratu, Asrat EliasErgena, Ousman Abubeker, Gizework Alemnew Mekonnen
A change of therapy from one to another antipsychotic medication is currently the main challenge of therapy. This study aimed to assess the prevalence of antipsychotic medication switches and determinants among patients with schizophrenia in Northwest Ethiopia. Multi-center hospital-based cross-sectional study was conducted at five Comprehensive Specialized Hospitals found in Northwest Ethiopia from
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Weight change following diagnosis with psychosis: a retrospective cohort study in Greater Manchester, UK Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2024-01-03 Adrian Heald, Chris Daly, John Julian Warner-Levy, Richard Williams, Cheyenne Meehan, Mark Livingston, Toby Pillinger, Lamiece Hussain, Joseph Firth
Weight gain in the months/years after diagnosis/treatment of severe enduring mental illness (SMI) is a major predictor of future diabetes, dysmetabolic profile and increased risk of cardiometabolic diseases. There is limited data on the longer-term profile of weight change in people with a history of SMI and how this may differ between individuals. We here report a retrospective study on weight change
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Effect of perceived stigma on work and social roles among individuals with mental health disorders in Saudi Arabia: findings from a national survey Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-12-14 Areej AlFattani, Lisa Bilal, Sami Y. Saad, Mohammad Talal Naseem, Sanaa Hyder, Abdulhamid Alhabib, Abdullah Alsubaie, Yasmin Altwaijri
It is known worldwide that stigma towards mental illness exists. Studies on stigma perceived by patients with mental illness have shown decreased quality of life and a negative impact on work, school and social life. The aim of this study was to estimate the prevalence of perceived stigma among respondents who had been diagnosed with a mental illness during the past 12 months, its association with
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Sex difference in incidence of major depressive disorder: an analysis from the Global Burden of Disease Study 2019 Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-12-12 Sangzi Li, Xuan Zhang, Yilu Cai, Leilei Zheng, Hu Pang, Lixia Lou
Major depressive disorder (MDD) is a leading mental disorder causing severe impairment. This study was aimed to evaluate sex difference in global MDD incidence by year, age, and socioeconomic status, according to the Global Burden of Disease Study 2019 (GBD 2019). Global and national sex-specific incidence estimates of MDD, from 1990 to 2019, in different age groups, were extracted from the GBD 2019
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Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-12-12 Keita Tokumitsu, Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Norio Yasui-Furukori
Bipolar disorder is a mental illness characterized by recurring episodes of mania and depression and is known to cause social impairment. Additionally, it has been revealed that bipolar disorder increases the risk of divorce and loss of family member support, which can worsen the prognosis. However, there is limited evidence regarding the predictive factors of divorce among patients with bipolar disorder
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Clinical characteristics of suicidal behavior in first hospitalization and drug-naïve patients with major depressive disorder Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-12-06 Xianzhi Sun, Lili Yin, Yingying Zhang, Xuebing Liu, Jun Ma
Major depressive disorder (MDD) is a major and common cause of suicide. The purpose of this article is to report the clinical characteristics and patterns of co-morbid suicidal behavior (SB) in first hospitalized and drug-naïve MDD patients. A total of 345 patients with first hospitalization and drug-naïve MDD with SB were included in this study, while 183 patients without SB were included as a control
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Facts and myths about the use of lithium for bipolar disorder in routine clinical practice: an expert consensus paper Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-12-06 Andrea Fiorillo, Gaia Sampogna, Umberto Albert, Giuseppe Maina, Giulio Perugi, Maurizio Pompili, Gianluca Rosso, Gabriele Sani, Alfonso Tortorella
Bipolar disorder is one of the most burdensome severe mental disorders, characterized by high levels of personal and social disability. Patients often need an integrated pharmacological and non-pharmacological approach. Lithium is one of the most effective treatments available not only in psychiatry, but in the whole medicine, and its clinical efficacy is superior to that of other mood stabilizers
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Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-24 Luis M. Garcia-Marin, Aoibhe Mulcahy, Enda M. Byrne, Sarah E. Medland, Naomi R. Wray, Freddy Chafota, Penelope A. Lind, Nicholas G. Martin, Ian B. Hickie, Miguel E. Rentería, Adrian I. Campos
Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographic characteristics, psychiatric comorbidities, and specific side effects associated with treatment discontinuation. We leveraged data from the Australian Genetics of Depression Study (AGDS; N = 20
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Nationwide consensus on the clinical management of treatment-resistant depression in Italy: a Delphi panel Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-23 Giuseppe Maina, Marina Adami, Giuseppe Ascione, Emi Bondi, Domenico De Berardis, Dario Delmonte, Silvia Maffezzoli, Giovanni Martinotti, Alessandra Nivoli, Elena Ottavianelli, Andrea Fagiolini
Treatment-resistant depression (TRD) is defined by the European Medicines Agency as a lack of clinically meaningful improvement after treatment, with at least two different antidepressants. Individual, familiar, and socio-economic burden of TRD is huge. Given the lack of clear guidelines, the large variability of TRD approaches across different countries and the availability of new medications to meet
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Mendelian randomization studies of depression: evidence, opportunities, and challenges Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-23 Wang-ran Ma, Lei-lei Zhang, Jing-ying Ma, Fang Yu, Ya-qing Hou, Xiang-rui Feng, Lin Yang
Major depressive disorder (MDD) poses a significant social and economic burden worldwide. Identifying exposures, risk factors, and biological mechanisms that are causally connected to MDD can help build a scientific basis for disease prevention and development of novel therapeutic approaches. In this systematic review, we assessed the evidence for causal relationships between putative causal risk factors
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A multicenter, randomized controlled study on the efficacy of agomelatine in ameliorating anhedonia, reduced motivation, and circadian rhythm disruptions in patients with major depressive disorder (MDD) Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-13 Ping Guo, Yong Xu, Liang Lv, Min Feng, Yu Fang, Wei-Quan Huang, Shan-Fei Cheng, Min-Cai Qian, Shengliang Yang, Shi-Kai Wang, Huan-Xin Chen
To evaluate the clinical efficacy and safety of Agomelatine in improving symptoms in patients with major depressive disorder (MDD), providing more scientific evidence for the treatment of depression, and offering more effective therapeutic options for patients. A total of 180 MDD patients in acute phase from 10 psychiatric hospitals of Grade three in Zhejiang Province were enrolled in this 12-week
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Randomized clinical trial of low dose suramin intravenous infusions for treatment of autism spectrum disorder Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-06 David Hough, Alice R. Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan, Robert L. Findling
There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial function and reduction of neuro-inflammation via its known antagonism of P2X and P2Y receptors. Nonclinical studies in fragile X knockout mice and the maternal immune activation model support
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Borderline personality disorder and early psychosis: a narrative review Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-02 Arianna Biancalani, Lorenzo Pelizza, Marco Menchetti
The purpose of the present review was to summarize the main literature contribution on the relationship between borderline personality disorder (BPD) and early psychosis. While retracing the historical path of the term “borderline”, specific attention was paid to psychotic and psychotic-like symptoms in BPD. Its relationship with At Risk Mental State was evaluated, as well. This search was conducted
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A shift in psychiatry through AI? Ethical challenges Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-11-02 Saskia Wilhelmy, Giancarlo Giupponi, Dominik Groß, Klaus Eisendle, Andreas Conca
The digital transformation has made its way into many areas of society, including medicine. While AI-based systems are widespread in medical disciplines, their use in psychiatry is progressing more slowly. However, they promise to revolutionize psychiatric practice in terms of prevention options, diagnostics, or even therapy. Psychiatry is in the midst of this digital transformation, so the question
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Psychometric properties of the Clinical Assessment Interview for Negative Symptoms (CAINS) in patients with depression and its relationship to affective symptoms Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-26 Johan Bengtsson, Parya Rad, Martin Cernvall, Robert Bodén
There is a conceptual overlap between negative and depressive symptoms, requiring further exploration to advance the understanding of negative symptoms. The aim of this study was to examine psychometric properties of the Clinical Assessment Interview for Negative Symptoms (CAINS) in patients with depression, and to explore the relationship between the negative and affective symptoms domains. Fifty-one
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Stress, depression, anxiety, and quality of life among the healthcare workers during COVID-19 pandemic in Syria: a multi-center study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-16 Hasan Nabil Al Houri, Abdullah Alhouri, Douaa Mohammad Nazir Arrouk, Ahmad Nabil Al Houri, Sami Jomaa, Alaa Sharabi, Hussein Kannout, Youssef Latifeh
The COVID-19 pandemic emerged as an expected source of stress and anxiety as the healthcare workers had to work for long hours in close contact with infected patients, thus increasing the probability of medical errors and threatening the patients’ safety. This study aims to measure the levels of depressive symptoms, anxiety symptoms, and stress among Syrian healthcare workers and their quality of life
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DNMT1 SNPs (rs2114724 and rs2228611) associated with positive symptoms in Chinese patients with schizophrenia Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-13 Junjiao Ping, Jing Wan, Caiying Huang, Jinming Yu, Jiali Luo, Zhiqiang Xing, Xingguang Luo, Baoguo Du, Tingyun Jiang, Jie Zhang
Schizophrenia is a serious mental disorder with complex clinical manifestations, while its pathophysiological mechanism is not fully understood. Accumulated evidence suggested the alteration in epigenetic pathway was associated with clinical features and brain dysfunctions in schizophrenia. DNA methyltransferases (DNMTs), a key enzyme for DNA methylation, are related to the development of schizophrenia
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Catatonia-like behavior and immune activation: a crosstalk between psychopathology and pathology in schizophrenia Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-11 Antonino Messina, Filippo Caraci, Eugenio Aguglia, Maria Salvina Signorelli
In Kalhbaum's first characterization of catatonia, the emotional symptoms, such as decreased or restricted expression of feelings and emotions, which is described as blunted affect, are related to the motor symptoms. In later years, the affective domain was excluded from the concept of catatonia and was not included among the diagnostic criteria in the various Diagnostic Statistical Manual (DSM) versions
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Dynamics of depressive states among university students in Japan during the COVID-19 pandemic: an interrupted time series analysis Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-10 N. Shiraishi, M. Sakata, R. Toyomoto, K. Yoshida, Y. Luo, Y. Nakagami, A. Tajika, T. Watanabe, E. Sahker, T. Uwatoko, T. Shimamoto, T. Iwami, T. A. Furukawa
The coronavirus disease 2019 (COVID-19) pandemic was reported to have increased depression among university students which was associated with impairments in their campus lives. This study examined changes in depressive states among Japanese university students during the COVID-19 pandemic. A secondary data analysis from a factorial randomized controlled trial involving smartphone-based cognitive-behavioral
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Safety and effectiveness of oral medium to high dose blonanserin in patients with schizophrenia: subgroup analysis from a prospective, multicenter, post-marketing surveillance study in mainland China Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-10-06 Yuan Yang, Hongmin Ge, Xijin Wang, Xuejun Liu, Keqing Li, Gang Wang, Xiaodong Yang, Huaili Deng, Meijuan Sun, Ruiling Zhang, Jindong Chen, Duanfang Cai, Hong Sang, Xianglai Liu, Guilai Zhan, Guijun Zhao, Haiyun Li, Zhiyuan Xun
Blonanserin (BNS) had been undergoing post-market surveillance (PMS) since September 2018. Using the surveillance data, we did this analysis to assess the safety and effectiveness of different doses of BNS to explore a sufficient dose range of BNS in Chinese patients with schizophrenia (SZ). A 12-week, prospective, observational, single-arm, multicenter, open-label PMS was conducted. In this analysis
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The role of gut microbiota in the pathogenesis and treatment of postpartum depression Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-09-27 Sheng Zhang, Baili Lu, Gang Wang
Postpartum depression (PPD) is a common complication of pregnancy in women, and its pathogenesis mainly involves disturbances of the neuroendocrine regulation, immune system, neurotransmitters, hormone secretion, and the gut microbiome. Gut microbes play essential physiological and pathological roles in the gut-brain axis’ pathways which are involved in various central nervous system (CNS) and psychiatric
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The capacity to consent to treatment is altered in suicidal patients Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-09-09 Emilie Olié, Thomas Catanzaro, Manon Malestroit, Julio A. Guija, Lucas Giner, Philippe Courtet
Many patients with depression refuse treatment. Moreover, suicide attempters often display low perceived need of treatment and impaired decision-making. These observations raise questions about the capacity to treatment consent in depressed suicide attempters (SA). In patients with current depressive episode (N = 33 SAs and N = 27 non-SAs), consent capacity was evaluated with the MacArthur Competence
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Effect of acceptance and commitment therapy for depressive disorders: a meta-analysis Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-09-07 Bing Zhao, Qian Wang, Liping Wang, Jie Chen, Tongtong Yin, Jingxuan Zhang, Xiaojing Cheng, Ruihua Hou
To systematically evaluate the effect of Acceptance and Commitment Therapy (ACT) on depressive disorders. The electronic databases of Web of Science Core Collection, Pubmed, EMBASE, Cochrane Library, PsycInfo, CNKI, Wanfang and Weipu were used to select relevant publications. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic
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Extrapyramidal adverse events and anticholinergics use after the long-term treatment of patients with schizophrenia with the new long-acting antipsychotic Risperidone ISM®: results from matching-adjusted indirect comparisons versus once-monthly formulations of Paliperidone palmitate and Aripiprazole monohydrate in 52-week studies Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-09-02 Pedro Sánchez, Cecilio Álamo, Marcos Almendros, Max Schlueter, Anastasios Tasoulas, Javier Martínez
Risperidone ISM® is a newly developed long-acting injectable (LAI) treatment for schizophrenia in adults. In the absence of head-to-head comparisons with other similar antipsychotics, the objective of this study was to generate indirect evidence of some aspects of the safety and tolerability of Risperidone ISM compared to other LAI antipsychotics for treatment of patients with schizophrenia in the
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Role of trazodone in treatment of major depressive disorder: an update Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-09-02 Andrea Fagiolini, Ana González-Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H. Young, Eduard Vieta
Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant approved for major depressive disorder (MDD) in adults, has established efficacy that is comparable to other available antidepressants, and is effective for a range of depression symptoms
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Prevalence of mental disorders among middle school students in Shaoxing, China Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-08-28 Shuangyi Pei, Xiaoting Wu, Weijiang Ye, Linqi Fang, Haoqiang Zhang, Fanghua Zhou, Xiaofei Du, Xinyi Cao, Shengnan Ma, Yuanchu Li, Shuwen Xi, Pingping Xu
In China, adolescents account for about a quarter of those treated for mental disorders each year, and adolescent mental health issues have become a social hotspot. Although several epidemiological surveys of mental disorders have been conducted in China, no study has yet focused on the prevalence of mental disorders among adolescents in a certain region of Zhejiang. In the first stage, 8219 middle
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Characteristics and economic burden of patients with somatoform disorders in Chinese general hospitals: a multicenter cross-sectional study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-08-12 Xiangyun Yang, Jia Luo, Pengchong Wang, Yue He, Cong Wang, Lijuan Yang, Jing Sun, Zhanjiang Li
In China, patients with somatoform disorders (SFD) often seek medical treatment repeatedly in outpatient clinics of general hospitals, which increases unreasonable medical expenses. It is imperative to provide early screening to these patients and specialized treatment to reduce the unnecessary cost. This study aimed to screen patients with SFD in general hospitals using a new Chinese questionnaire
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Autism and intention attribution test: a non-verbal evaluation with comic strips Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-08-12 Ilenia Le Donne, Margherita Attanasio, Antony Bologna, Roberto Vagnetti, Francesco Masedu, Marco Valenti, Monica Mazza
Despite autism spectrum disorder (ASD) and mentalization being two words often associated in the literature, the assessment of this ability in individuals with ASD in the clinical setting is still limited. Indeed, there are no standardized Theory of Mind (ToM) tests that are adaptable to different cognitive profiles, such as individuals with language poverty, and intellectual or memory impairments
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Prevalence of suicidal thoughts and attempts in the transgender population of the world: a systematic review and meta-analysis Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-08-05 Parisa Kohnepoushi, Maziar Nikouei, Mojtaba Cheraghi, Parsa Hasanabadi, Hamza Rahmani, Maryam Moradi, Ghobad Moradi, Farhad Moradpour, Yousef Moradi
The aim of this meta-analysis was to determine global pooled prevalence of suicide thoughts and attempts in transgender population. For doing comprehensive search strategy related to objectives in the presence meta-analysis, all international databases like PubMed (Medline), Scopus, Embase, Web of Sciences, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature (CINHAL) were searched
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16S rRNA gene sequencing reveals the effect of fluoxetine on gut microbiota in chronic unpredictable stress-induced depressive-like rats Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-08-03 Hui Dong, Xiaowei Tang, Jie Ye, Wenhuan Xiao
Gut microbiota is relevant to the pathogenesis of mental disorders including depression. This study aimed to investigate the influence of fluoxetine (FLX) on the gut microbiota in rats with Chronic Unpredictable Mild Stresses (CUMS)-induced depression. We confirmed that the 28-day CUMS-induced depression rat model. Chronic FLX administration weakly improved depressive-like behaviors in rats. Illumina
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Effect of the decreased frequency of going out on the association between anxiety and sleep disorder during the COVID-19 pandemic: a mediation analysis Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-07-23 Yumi Sugawara, Yutaka Yabe, Yoshihiro Hagiwara, Ichiro Tsuji
The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency of going out. The data of a total of 1976 residents aged 18 years and over who had responded to a self-reported questionnaires at a health survey in 2020 were analyzed. The subjects were divided
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Gender differences in prevalence and associated factors of metabolic syndrome in first-treatment and drug-naïve schizophrenia patients Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-06-28 Kuan Zeng, Shuo Wang, Lin Zhang, Yanting Zhang, Jun Ma
Metabolic syndromes (MetS) are clinical syndromes involving multiple pathological states with distinct gender-specific clinical patterns. As a serious disorder associated with psychiatric conditions, the prevalence of MetS is significantly higher in the population with schizophrenia (Sch). The aim of this paper is to report gender differences in the prevalence, associated factors and severity-related
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Understanding inequalities in mental health by family structure during COVID-19 lockdowns: evidence from the UK Household Longitudinal Study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-06-06 Michael J. Green, Peter Craig, Evangelia Demou, S. Vittal Katikireddi, Alastair H. Leyland, Anna Pearce
The COVID-19 pandemic increased psychiatric distress and impacts differed by family structure. We aimed to identify mechanisms contributing to these inequalities. Survey data were from the UK Household Longitudinal Study. Psychiatric distress (GHQ-12) was measured in April 2020 (first UK lockdown; n = 10,516), and January 2021 (lockdown re-introduced following eased restrictions; n = 6,893). Pre-lockdown
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Sleep disorders related to index and comorbid mental disorders and psychotropic drugs Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-27 Ray M. Merrill, McKay K. Ashton, Emily Angell
Mental disorders positively associate with sleep disorders. This study will explore the moderating influence of comorbid mental disorders and whether selected psychotropic drugs correlate with sleep disorders after adjusting for mental disorders. A retrospective cohort study design was employed using medical claim data from the Deseret Mutual Benefit Administrators (DMBA). Mental disorders, psychotropic
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The relationship between coping strategies with sexual satisfaction and sexual intimacy in women with multiple sclerosis Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-25 Samaneh Imanpour Barough, Hedyeh Riazi, Zohreh Keshavarz, Maliheh Nasiri, Ali Montazeri
Multiple sclerosis profoundly affects the sexual aspects of patients’ life, especially in women. Various coping strategies are used by women with multiple sclerosis to overcome, tolerate, or minimize these sexual effects. The present study aimed to assess the relationship between sexual satisfaction, sexual intimacy, and coping strategies in women with multiple sclerosis. This cross-sectional study
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Gut microbiota and its relation to inflammation in patients with bipolar depression: a cross-sectional study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-19 Tingting Huang, Yushan Shang, Chunxiao Dai, Qixiu Zhang, Shaohua Hu, Jian Xie
To explore the gut microbiota characteristics in depressed patients with bipolar disorder (BD) as well as the connection between the gut microbiota and inflammatory markers. Totally 72 depressed BD patients and 16 healthy controls (HCs) were enrolled in the study. Blood and feces samples were taken from each subject. With the help of 16S-ribosomal RNA gene sequencing, the characteristics of the gut
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Study on association of serum uric acid levels with bipolar disorder: systematic review and meta-analysis in Chinese patients Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-18 Haihan Chen, Fengli Sun, Weidong Jin
The purine system represented by uric acid may be involved in the pathogenesis of bipolar disorder, This study intends to explore the association of serum uric acid levels with bipolar disorder in Chinese patients through meta-analysis. Electronic databases, including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI), searching from inception to December 2022. Randomized
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Long-term consequences of COVID-19 on mental health and the impact of a physically active lifestyle: a narrative review Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-11 Leonardo Roever, Bruno Raphael Ribeiro Cavalcante, Alex Cleber Improta-Caria
Coronavirus-19 disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Respiratory viruses damage not only the upper respiratory tract in humans, but also several different organs such as the brain. Some of the neurological consequences of COVID-19 reported are anosmia, headache, stroke, declined cognitive function, and impaired mental health, among others
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Alternation in functional connectivity within default mode network after psychodynamic psychotherapy in borderline personality disorder Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-05-11 Saba Amiri, Fatemeh Sadat Mirfazeli, Jordan Grafman, Homa Mohammadsadeghi, Mehrdad Eftekhar, Nazila Karimzad, Maryam Mohebbi, Shabnam Nohesara
Borderline personality disorder (BPD) is characterized by impairments in emotion regulation, impulse control, and interpersonal and social functioning along with a deficit in emotional awareness and empathy. In this study, we investigated whether functional connectivity (FC) within the default mode network (DMN) is affected by 1-year psychodynamic psychotherapy in patients with BPD. Nine BPD patients
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Two clinicians for one patient, is it worth it? Patients’ perspective on receiving treatment from a pair of clinicians, in a psychiatric emergency and crisis unit Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-04-27 Caroline Dedeystère Pobelov, Orest Weber, Sonia Krenz, Yves Dorogi, Laurent Michaud
In the field of psychiatric crisis interventions, treatment is commonly provided by multidisciplinary teams in Western countries. However, empirical data on the processes involved in this type of intervention are lacking, in particular from a patient perspective. Our study aims to gain a better understanding of the patients’ experience of a treatment setting provided by a pair of clinicians in a psychiatric
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Canadian pediatric eating disorder programs and virtual care during the COVID-19 pandemic: a mixed-methods approach to understanding clinicians’ perspectives Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-04-26 Kaylee Novack, Rachel Dufour, Louis Picard, Danielle Taddeo, Pierre-Olivier Nadeau, Debra K. Katzman, Linda Booij, Nicholas Chadi
As a result of the public health measures put in place during the COVID-19 pandemic in Canada, many health services, including those for the treatment of eating disorders, were provided at a distance. This study aims to describe the adaptations made in specialized pediatric eating disorder programs in Canada and the impact of these adaptations on health professionals’ experience of providing care.
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Estimating the risk of irreversible post-SSRI sexual dysfunction (PSSD) due to serotonergic antidepressants Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-04-21 Joseph Ben-Sheetrit, Yehonathan Hermon, Shlomo Birkenfeld, Yehiel Gutman, Antonei B. Csoka, Paz Toren
Sexual dysfunction is a common side effect of Serotonergic antidepressants (SA) treatment, and persists in some patients despite drug discontinuation, a condition termed post-SSRI sexual dysfunction (PSSD). The risk for PSSD is unknown but is thought to be rare and difficult to assess. This study aims to estimate the risk of erectile dysfunction (ED) and PSSD in males treated with SAs. A 19-year retrospective
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Assessments of functional outcomes and its determinants among bipolar disorder patients in Northwest Ethiopia comprehensive specialized hospitals: a multicenter hospital-based study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-04-06 Melak Erara Mengistu, Simegnew Handebo Berassa, Abebe Tarekegn Kassaw, Ephrem Mebratu Dagnew, Gizework Alemnew Mekonen, Mequanent Kassa Birarra
Bipolar disorder is a severe and chronic mental illness that could continue for a lifetime. Although it is a leading cause of disability and impairments for significant numbers of patients, the levels of functional outcomes have not been studied in Ethiopia. Therefore, this study aimed to assess the functional outcome levels and associated factors among bipolar disorder patients in Northwest Ethiopia
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The economic and humanistic burden of bipolar disorder in adults in the United States Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-24 Carole Dembek, deMauri Mackie, Kushal Modi, Yingying Zhu, Xiaoli Niu, Todd Grinnell
Bipolar disorder is associated with functional impairment and diminished health-related quality of life (HRQoL). The purpose of this study was to estimate the annual per patient direct healthcare costs, indirect costs, and HRQoL of patients with bipolar disorder by depressive symptom severity and overall compared to the general population in the US. This cross-sectional study used self-reported data
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Correlates of long duration of untreated illness (DUI) in patients with bipolar disorder: results of an observational study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-23 Gabriele Di Salvo, Giorgia Porceddu, Umberto Albert, Giuseppe Maina, Gianluca Rosso
Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality and medical comorbidities, are still inconsistent. This cross-sectional observational study aimed at analyzing potential socio-demographic and clinical correlates
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Endocannabinergic modulation of central serotonergic activity in healthy human volunteers Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-17 Barbara Emons, Larissa Arning, Vera-Estelle Makulla, Maria-Theresia Suchy, Dimitrios Tsikas, Thomas Lücke, Jörg T. Epplen, Georg Juckel, Patrik Roser
The serotonergic and the endocannabinoid system are involved in the etiology of depression. Depressive patients exhibit low serotonergic activity and decreased level of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol (2AG). Since the cannabinoid (CB) 1 receptor is activated by endogenous ligands such as AEA and 2AG, whose concentration are controlled by the fatty acid amide hydrolase
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Suicide and COVID-19: a rapid scoping review Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-17 Tommaso Barlattani, Chiara D’Amelio, Francesco Capelli, Simonetta Mantenuto, Rodolfo Rossi, Valentina Socci, Paolo Stratta, Ramona Di Stefano, Alessandro Rossi, Francesca Pacitti
There is considerable interest in exploring effects of coronavirus disease 2019 (COVID-19) pandemic on mental health. Suicide is one of the leading causes of mortality worldwide and changes in daily life brought by the pandemic may be additional risk factors in people with pre-existing mental disorders. This rapid PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension
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The role of emotional instability in borderline personality disorder: a systematic review Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-14 Giulia D’Aurizio, Ramona Di Stefano, Valentina Socci, Alessandro Rossi, Tommaso Barlattani, Francesca Pacitti, Rodolfo Rossi
The emotional regulation process plays a pivotal role in daily-life functioning, modulating goal-directed and adaptive behavior. Conversely, altering this cognitive function can disrupt self-regulation and bring emotional dysregulation. Emotional instability could represent a core characteristic of BPD, also modulating the BPD symptom's onset. This systematic review aims to summarize the existing literature
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Participation in leisure activities and quality of life of people with psychosis in England: a multi-site cross-sectional study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-13 Kayonda Hubert Ngamaba, Martin Webber, Penny Xanthopoulou, Agnes Chevalier, Domenico Giacco
Leisure activities can improve quality of life in the general population. For people with psychosis, negative symptoms (e.g. being unmotivated, difficulty in sticking with activities) are often a barrier to engaging in social leisure activities. However, we do not know if participation in leisure activities is associated with quality of life in this group and, whether psychosocial interventions should
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Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-03-11 Chadia Haddad, Angela Chamoun, Hala Sacre, Souheil Hallit, Pascale Salameh, Benjamin Calvet
It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed to evaluate changes in cognitive function before and after COVID-19 and associated factors among patients with schizophrenia at the Psychiatric Hospital of the Cross (HPC). A prospective cohort
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Relationship between efficacy and common metabolic parameters in first-treatment drug-naïve patients with early non-response schizophrenia: a retrospective study Ann. Gen. Psychiatr. (IF 3.7) Pub Date : 2023-02-17 Junhong Zhu, Jiajia Wu, Xuebing Liu, Jun Ma
Comorbid metabolic disorders in patients with schizophrenia are very common. Patients with schizophrenia who respond to therapy early are often strongly predictive of better treatment outcomes. However, the differences in short-term metabolic markers between early responders and early non-responders in schizophrenia are unclear. 143 first-treatment drug-naïve schizophrenia patients were included in