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The relevance of anti-N-methyl-d-aspartate receptor encephalitis for psychiatrists Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2024-03-04 Denis Pavăl, Nicoleta Gherghel-Pavăl, Octavia Oana Căpățînă, Adina Stan, Ioana Valentina Micluția
Psychiatrists are often the first to be consulted in patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. While this disease is rare, psychiatrists need to be aware of its relevan...
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Prevalence and risk factors for metabolic syndrome in schizophrenia, schizoaffective, and bipolar disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2024-02-08 Hind Mohd Ahmed, Karim Abdel Aziz, Abeer Al Ammari, Mohammed Galadari, Aaisha Alsaadi, Aysha Alhassani, Fatima Al Marzooqi, Mohammed AlAhbabi, Hind Alsheryani, Meera Bahayan, Reem Ahmed, Sara Alameri, Emmanuel Stip, Dina Aly El-Gabry
Metabolic Syndrome (MetS) is a risk for developing cardiovascular diseases and its prevalence is especially high in psychiatric patients. To date, there is limited data from the United Arab Emirate...
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Depressive symptoms in the entire spectrum of cognitive ageing in Greece: evidence from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-12-25 Eleni-Zacharoula (Eliza) Georgiou, Antonios Politis, Mary H. Kosmidis, Mary Yannakoulia, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Polychronis Economou, Panagiotis Alexopoulos
To study (i) the prevalence of mild and moderate-to-severe depressive symptoms in the entire spectrum of cognitive ageing in Greece and (ii) the relationship between these symptoms and demographic ...
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Hoarding behaviour: special features and complications in real-world clinical practice Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-11-29 David Córcoles, Lucía Guerrero, Angeles Malagon, Magda Bellsolà, Ana Maria Gonzalez, Jordi León, Agnès Sabaté, Victor Pérez, Antoni Bulbena, Luis Miguel Martín, Anna Mane
Hoarding behaviour is a common but poorly characterised problem in real-world clinical practice. Although hoarding behaviour is the key component of Hoarding Disorder (HD), there are people who exh...
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Sertraline with desvenlafaxine and sertraline with mirtazapine as treatment initiation in MDD patients with moderate to severe depression and effect on inflammatory markers Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-11-29 Norman Arockiaraj, Rachna Gupta, Rafat Ahmad, Sumita Halder, M. S. Bhatia
This study evaluated the effect of sertraline with desvenlafaxine and sertraline with mirtazapine on HAM-D score and inflammatory markers (IL-6 and TNF-α levels) in major depressive disorder.Patien...
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Does attention deficit hyperactivity disorder worsen family functioning and parenting styles? A case control study Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-11-28 Mehmet Karadağ, Gizem Yılmaz Saygılı, Zehra Topal Hangül, Fatma Subaşı Turgut
A bidirectional relationship between family functioning and parenting styles and Attention Deficit and Hyperactivity Disorder (ADHD) is proposed. The aim of this study is to examine the effect of A...
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Cheers and a thank-you note from the founding chief-editor Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-11-07 Siegfried Kasper
Published in International Journal of Psychiatry in Clinical Practice (Vol. 27, No. 4, 2023)
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Which clinical factors and biochemical parameters are associated with late-life major depression? Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-11-07 Massimiliano Buoli, Francesca Legnani, Guido Nosari, Anna Pan, Valentina Ciappolino, Cecilia Maria Esposito, Alessandro Ceresa, Martina Di Paolo, Teresa Surace, Anna Maria Auxilia, Martina Capellazzi, Ilaria Tagliabue, Luisa Cirella, Francesco Zanelli Quarantini, Antonios Dakanalis, Massimo Clerici, Enrico Capuzzi, Alice Caldiroli
Late-life major depression (MD) is a frequent and high-cost psychiatric disorder. Our purpose was to detect clinical and biological factors possibly associated with this condition to better prevent...
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Depression and atrial fibrillation in a reciprocal liaison: a neuro-cardiac link Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-08-24 Theodora A. Manolis, Antonis A. Manolis, Evdoxia J. Apostolopoulos, Helen Melita, Antonis S. Manolis
To explore the reciprocal relationship of depression and atrial fibrillation (AF).A literature search was conducted in Pub Med, Scopus, and Google Scholar using relevant terms for depression and AF...
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Treating postpartum affective and/or anxiety disorders in a mother-baby day hospital: preliminary results Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-08-02 Alba Roca-Lecumberri, Anna Torres, Susana Andrés, Cristina López, Carmen Naranjo, Ester Roda, Lluïsa Garcia-Esteve, Estel Gelabert
Women experiencing perinatal mental-health illness have unique needs. The present study analyzes preliminary data about the effectiveness of MBDH in treating postpartum women with affective and anx...
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Elevated C-reactive protein/albumin ratio in patients with methamphetamine use disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-07-21 Ali Baran Tanrıkulu, Hilal Kaya, Zekiye Çatak
Methamphetamine use disorder causes significant crises, which have individual, familial, and social consequences. Identifying inflammatory biomarkers for methamphetamine use disorder may be useful ...
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Hospitalisation outcomes for patients with severe mental illness treated by female vs. male psychiatry residents Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-07-20 Amit Yaniv-Rosenfeld, Ariel Rosenfeld, Hagai Maoz
Recent literature suggests that female physicians provide higher quality of care compared to their male counterparts across a variety of physical medical conditions. We examine whether a similar ph...
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Evolution and trends of hikikomori: a bibliometrics analysis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-07-15 Wan Mohd Hirwani Wan Hussain
Hikikomori is the Japanese term for the phenomenon of young adults isolating themselves from society and becoming reclusive. This study aims to examine the evolution and distribution of hikikomori,...
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Switching antipsychotics to partial dopamine D2-agonists in individuals affected by schizophrenia: a narrative review Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-07-10 Pierre Baumann, Philipp Bauknecht, Maxim Kuzin, Georgios Schoretsanitis
The aim of this review is to analyse the literature regarding studies centred on the clinical outcome of individuals affected by schizophrenia and treated with various antipsychotics, and then swit...
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Episodic obsessive-compulsive disorder and bipolar spectrum disorder: new evidence from a large Italian OCD sample Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-07-04 Stefano Bramante, Sylvia Rigardetto, Roberta Borgogno, Emina Mehanović, Luca Pellegrini, Umberto Albert, Giuseppe Maina
Obsessive-Compulsive Disorder (OCD) has been considered to be a chronic illness; however, some authors described a subtype of OCD characterised by symptom-free periods of time: Episodic-OCD (E-OCD)...
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Recollecting Hanns Hippius: a stimulating pioneer of psychopharmacology and neuroscience Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-06-23 Hans-Jürgen Möller
Abstract Hanns Hippius (1925–2021) can be seen as a stimulating pioneer of Psychopharmacology and of Neuroscience. He was very influential in this area not only in Germany, but also on an international level. With reference to clinical psychopharmacology especially his activities for the development of Clozapine are of greatest importance. When he became Chairman of the Psychiatric Department of the
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The effect of bright light therapy on irritability in bipolar depression: a single-blind randomised control trial Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-06-12 Lorenzo Fregna, Francesco Attanasio, Cristina Colombo
The symptom-complex irritability, widely used in descriptions of bipolar patients’ manic and mixed states, also represents a common feature in depressive phases. Irritability negatively affects the...
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Preparing for the next pandemic by understanding the impact of COVID-19 mitigation measures on patients with eating Disorders: observations from an inpatient setting Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-06-09 Patrizia Todisco, Paolo Meneguzzo, Alice Garolla, Athos Antoniades, Paris Vogazianos, Federica Tozzi
The COVID-19 pandemic overwhelmed eating disorder (ED) services worldwide. Data suggests a worsening of psychopathology and an increased request for specialised treatments. Still, the studies are m...
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Assessment tools for complex post traumatic stress disorder: a systematic review Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-04-17 Natalie Seiler, Keivan Davoodi, Michael Keem, Subhash Das
Abstract Appropriate screening tools are required to accurately detect complex post traumatic stress disorder (CPTSD). This systematic review aimed to assess and compare measurement tools. A literature search using key words ‘complex post traumatic stress disorder’, ‘PTSD’, and ‘assessment’ was undertaken on Embase and PsychINFO during February 2022 by two reviewers. Inclusion criteria included full
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Psychiatric manifestations of post-COVID-19 syndrome: the potential benefit of Silexan Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-04-06 Siegfried Kasper, Anne Eckert, Hans-Jürgen Möller, Hans-Peter Volz, Erich Seifritz
Abstract Objective: Psychiatric symptoms are common and bothersome in individuals with post-COVID-19 syndrome. Because they are often mixed and subthreshold, established treatment regimens cannot be applied. There is an urgent need to identify therapeutics for affected patients. Silexan, a proprietary essential oil from Lavandula angustifolia, has demonstrated efficacy against anxiety, comorbid symptoms
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Engendering misunderstanding: autism and borderline personality disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-03-16 Jay Watts
Abstract Objective and Method: Female autism can be misdiagnosed as borderline personality disorder, leading to mistreatment and unnecessary harm. By educating clinicians on how female autism can mimic borderline personality disorder, we can increase the accuracy and effectiveness of diagnosis, ultimately improving patient outcomes. Result: There is a common myth that clinicians can easily recognise
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Gender differences in empathy and clinical symptoms in chronic schizophrenia patients: a large sample study based on a Chinese Han population Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-01-31 Yanli Li, Yongjie Zhou, Yuchen Li, Rui-Chen-Xi Luo, Pallavi B. Ganapathi, Hanjing Emily Wu, Huanzhong Liu, Dongmei Wang, Xiangyang Zhang
Abstract Background Empathy is social cognition and reduced empathy in schizophrenia (SCZ) has been noted; however, whether there are gender differences in empathy remains unclear. Therefore, the purpose of this study was to explore this issue by examining a large sample of the population with SCZ. Methods We recruited 987 SCZ patients (M/F = 638/349). The empathy was assessed by The Interpersonal
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Chronotype is associated with affective temperaments, clinical severity and worse treatment outcomes in bipolar disorders: results from a two-center, cross-sectional study Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2023-01-09 Giulia Menculini, Luca Jr. Steardo, Norma Verdolini, Martina D’Angelo, Elena Chipi, Federica Cirimbilli, Laura Orsolini, Umberto Volpe, Pasquale De Fazio, Alfonso Tortorella
Abstract Objective The present study was aimed at investigating the clinical correlates of evening chronotype in a population of subjects suffering from bipolar disorders (BD). Methods We assessed chronotype using the Morningness-Eveningness Questionnaire. We administered the brief Temperament Evaluation of Memphis, Pisa, and San Diego, the Barratt Impulsiveness Scale, and the Alda Scale to evaluate
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Questions arising from the application of the ICD-11 diagnoses of complex post traumatic stress disorder and personality disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-12-29 Andrew White, Anna Hudson
Abstract There is an overlap between the International Classification of Diseases for Mortality and Morbidity Statistics- 11th Revision (ICD-11) diagnoses of complex post-traumatic stress disorder (CPTSD) and personality disorder. When the latter is comorbid with post-traumatic stress disorder (PTSD), this may allow for a false positive CPTSD diagnosis. This fact has both clinical implications and
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Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: an explorative analysis on symptom dimensions Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-12-28 Mustafa Tuncturk, Cagatay Ermis, Dicle Buyuktaskin, Serkan Turan, Yesim Saglam, Sezen Alarslan, Duru Guler, Ekin Sut, Guldal Unutmaz, Ayse Beste Guzel, Ozge Atay Canbek, Neslihan Inal, Gul Karacetin, Philip Hazell
Abstract Objective This study sought to compare pre-intervention patient characteristics and post-intervention outcomes in a naturalistic sample of adolescent inpatients with treatment-resistant psychotic symptoms who received either electroconvulsive therapy (ECT) or clozapine. Methods Data of adolescents with schizophrenia/schizoaffective disorder receiving ECT or clozapine were retrospectively collected
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The impact of the second wave of COVID-19 on liaison psychiatry: a comparative retrospective study with the homologous non-pandemic period Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-12-23 Filipa Caldas, Margarida Vasconcelos Araújo, Palmira Coya, Rodrigo Valido, Catarina Oliveira
Abstract Objective To determine the impact of COVID-19 pandemic (COVID-19-P) on clinical and health organisational variables of patients evaluated by Liaison Psychiatry (LP). Methods Revision of all collaboration requests (CR) to LP for patients hospitalised in a Portuguese General Hospital during the second wave of COVID-19-P, from 1 October to 31 December of 2020. Medical charts were analysed and
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Effects of exercise on obsessive-compulsive disorder symptoms: a systematic review and meta-analysis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-12-21 Lindsay Bottoms, Montserrat Prat Pons, Naomi A. Fineberg, Luca Pellegrini, Oliver Fox, David Wellsted, Lynne M. Drummond, Jemma Reid, David S. Baldwin, Ruihua Hou, Samuel Chamberlain, Nick Sireau, Dominique Grohmann, Keith R. Laws
Abstract Objective This systematic review and meta-analysis assessed the efficacy of exercise in reducing OCD symptoms. Methods We searched PubMed, Cochrane Central Register of Controlled Trials, MEDLINE, Scopus and grey literature until March 2022. The study was preregistered at Prospero (CRD42021283931). We included randomised controlled and pre-post trials assessing physical activity as an intervention
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Dopamine partial agonists: a discrete class of antipsychotics Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-12-10 David Taylor, Ramalingam Chithiramohan, Jasdev Grewal, Avirup Gupta, Lars Hansen, Gavin P. Reynolds, Sofia Pappa
Abstract Worldwide, there are now three marketed dopamine D2 partial agonists: aripiprazole, brexpiprazole and cariprazine. These three drugs share a number of properties other than their action at D2 receptors. Pharmacologically, they are 5HT2 antagonists and D3 and 5HT1A partial agonists but with little or no alpha-adrenergic, anticholinergic or antihistaminic activity. They also share a long duration
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Relations between clinical characteristics and cognitive deficits among adult patients diagnosed with major depressive disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-11-30 Natasha Subhas, Jin Kiat Ang, Kit-Aun Tan, Siti Nor Aizah Ahmad
Abstract Objective The present study examined the relations between clinical characteristics and cognitive deficits in adult patients with major depressive disorder (MDD) from a local outpatient psychiatric clinic in Malaysia. Methods The present sample included 110 participants aged 20–60 years old. Participants were invited to provide their information on sociodemographic variables (age, gender,
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Editorial 4 Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-11-26 Siegfried Kasper
Published in International Journal of Psychiatry in Clinical Practice (Vol. 26, No. 4, 2022)
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Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-11-21 Erin Crowe, Maria C. Rosário, Ygor A. Ferrão, Lucy Albertella, Euripedes C. Miguel, Leonardo F. Fontenelle
Abstract Background Obsessional slowness (OS) is characterised by debilitating motor slowness during initiation and completion of daily tasks such as washing, dressing, eating or walking. Yet, the clinical features of OS are still poorly understood. Methods This study aimed to delineate demographics, comorbid disorders and obsessive-compulsive symptoms (OCS) associated with OS. Cross sectional data
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Clinical excellence in child and adolescent psychiatry: examples from the published literature Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-11-11 Amanda Y. Sun, Scott M. Wright, Leslie Miller
Abstract There has been growing interest in the past century in improving understanding of the development and treatment of psychopathology of children, with increasing government funding of research in the past two decades. However, child and adolescent psychiatry excellence in clinical care has not been well-documented in the existing literature. This article provides examples of clinical excellence
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Suicidality in patients with post-traumatic stress disorder and its association with receipt of specific secondary mental healthcare treatments Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-11-11 Elena Opie, Nomi Werbeloff, Joseph Hayes, David Osborn, Alexandra Pitman
Abstract Background Post-traumatic stress disorder (PTSD) is a risk factor for suicidality (suicidal ideation, and suicide attempt). This study described the prevalence of suicidality amongst a representative sample of individuals with PTSD and the association between suicidality and receipt of five PTSD treatments. Methods We analysed deidentified data for patients being treated for PTSD at Camden
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Association of anhedonia and suicidal ideation in patients with treatment-refractory depression after intravenous ketamine infusions Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-10-29 Wei Zheng, Li-Mei Gu, Xin-Hu Yang, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Yu-Ping Ning
Abstract Objectives Accumulating evidence suggests that the effects of ketamine administered intravenously at subanaesthetic doses on both anhedonic symptoms and suicidal ideation occur independently of depressive symptoms in major depressive disorder (MDD) and bipolar disorder (BD). This study sought to determine the relationship between anhedonia and suicidal ideation after serial ketamine infusions
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Editorial 3 Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-10-10 Siegfried Kasper
Published in International Journal of Psychiatry in Clinical Practice (Vol. 26, No. 3, 2022)
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Mental fatigue in individuals with psychiatric disorders: a scoping review Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-10-10 Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Abstract Objective The aim of this study was to complete a scoping review of the published literature describing the relationship between mental fatigue and various psychiatric disorders, to better understand its frequency and clinical impact, and to provide recommendations for future clinical research. Methods A scoping review using PubMed/MEDLINE, Cochrane and PsychArticles databases was conducted
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Part of the solution yet part of the problem: factors of schizophrenia stigma in mental health professionals Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-10-06 Kevin-Marc Valery, Louis Violeau, Thomas Fournier, Florence Yvon, Sophie Arfeuillere, Julien Bonilla-Guerrero, Aude Caria, Antonin Carrier, Jean-Marc Destaillats, Alice Follenfant, Sonia Laberon, Nadeja Lalbin-Wander, Eric Martinez, Bérénice Staedel, Roselyne Touroude, Luc Vigneault, Solenne Roux, Antoinette Prouteau
Abstract Background Stigma is highly prejudicial to persons with schizophrenia, their families, the society and the health care system. Mental health professionals (MHP) are considered to be one of the main sources of schizophrenia stigma. Objectives The aim of the study was to identify individual and contextual factors associated with stigma in MHP in its three dimensions (stereotypes, prejudices
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Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naïve schizophrenia Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-10-04 Huixia Zhou, Dongmei Wang, Bo Cao, Xiangyang Zhang
Abstract Objective There is growing evidence that reduced cortical thickness has been considered to be a central abnormality in schizophrenia. Brain imaging studies have demonstrated that the cerebral cortex becomes thinner in patients with first-episode schizophrenia. This study aimed to examine whether cortical thickness is altered in drug-naïve schizophrenia in a Chinese Han population and the relationship
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Assessment of compliance and relapse in patients with schizophrenia before and after the onset of COVID-19 pandemic Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-09-23 Medhat M. Bassiony, Mohammad G. Sehlo, Eman F. Ibrahim, Alaa E. Zayed, Samar A. Atwa
Abstract Objective The aim of this study was to assess the frequency and correlates of relapse among patients with schizophrenia during the COVID-19 pandemic. Methods This retrospective study included 90 adults who met DSM-IV criteria for schizophrenia. The participants were evaluated using Positive and Negative Syndrome Scale (PANSS), Compliance Rating Scale (CRS) and World Health Organisation Disability
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Serum brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in patients with first-episode depression at different ages Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-08-18 Xianping He, Jingyao Song, He Gao, Zhenyang Li, Xiaochun Wang, Qiaoling Zeng, Yucen Xiao, Jiaxin Feng, Dongdong Zhou, Gaomao Wang
Abstract Objectives We investigated the differences in serum brain-derived neurotrophic factor (BDNF) and glial cell line–derived neurotrophic factor (GDNF) levels and clinical symptoms with first-episode depression at different ages. Methods Ninety patients (15–60 years old) diagnosed with first-episode depression were enrolled as the study group, and they were divided into early-onset, adult and
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Thank you to reviewers Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-08-10
Published in International Journal of Psychiatry in Clinical Practice (Vol. 26, No. 2, 2022)
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Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of patients with schizophrenia: a case-control study Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-08-06 Gulin Ozdamar Unal, Kuyas Hekimler Ozturk, Huseyin Emre Inci
Abstract Objective This study aimed to evaluate the gene expression of the P2X purinoceptor 7 (P2X7R)- nod-like receptor pyrin domain-containing protein 3 (NLRP3) signal pathway in peripheral blood mononuclear cells (PBMCs) between schizophrenia (SCZ) patients and healthy controls (HC) to reveal its relationship with clinical variables. Methods Thirty-two SCZ patients and 41 healthy controls were included
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Effect of quetiapine on inflammation and immunity: a systematic review Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-08-01 Marco Ferrari, Marco Godio, Stefano Martini, Camilla Callegari, Marco Cosentino, Franca Marino
Abstract Introduction Knowledge about the neurobiology of psychiatric disorders is increasing in the last decades and evidence from literature suggests a central role for immuno-inflammatory mechanisms in these illnesses. The antipsychotic quetiapine acts on dopamine and serotonin signalling and well-established evidence demonstrates that these neurotransmitters can modulate immune functions in healthy
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Health care workers' mental health in the face of COVID-19: a systematic review and meta-analysis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-07-23 Sulmaz Ghahramani, Hengameh Kasraei, Ramin Hayati, Reza Tabrizi, Milad Ahmadi Marzaleh
Abstract Background Healthcare workers are leading the way in treating patients with coronavirus disease 2019 (COVID-19). Due to the high levels of psychological stress, this group is more likely to experience psychological issues. These psychological problems in healthcare providers include depression, anxiety, insomnia, stress and post-traumatic stress disorder (PTSD). The goal of this systematic
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Effect of risperidone on serum IL-6 levels in individuals with schizophrenia: a systematic review and meta-analysis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-07-15 Miguel Angel Ramos-Méndez, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Mario Villar-Soto, Alma Delia Genis-Mendoza, Thelma Beatriz González-Castro, María Lilia López-Narváez, José Jaime Martínez-Magaña, Rosa Giannina Castillo-Avila, Guillermo Efrén Villar-Juárez
Abstract Background Risperidone has been significant correlated with a direct effect of interleukin-6 (IL-6) levels in patients with schizophrenia. This fact allows the opportunity to link the probable immunomodulatory effect of antipsychotic medication. Specially, a proper functioning of IL-6 pathway plays a potential role in the treatment or development of schizophrenia. Objective Our primary aim
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Factors associated with sick leave duration in patients suffering from major depressive disorder initiating antidepressant treatment: a real-world evidence study in Germany and Spain Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-07-08 Miquel Roca, Annalisa Bonelli, Agnese Cattaneo, Alessandro Comandini, Giorgio Di Dato, Franca Heiman, Valeria Pegoraro, Siegfried Kasper, Hans-Peter Volz, Diego Palao
Abstract Objective To describe MDD patients starting antidepressant (AD) treatment by pharmacological approach and identify factors associated with a longer sick leave (SL) duration. Methods Retrospective study on IQVIA German Disease Analyser (specialists) and Spanish Longitudinal Patient Database (general practitioners and specialists). MDD patients initiating AD treatment between July 2016–June
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Aripiprazole for the treatment of schizophrenia: Recommendations of a panel of Spanish experts on its use in clinical practice Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-07-06 David Fraguas, David Almenta Gallego, Sergio Arques-Egea, Marcos Gómez-Revuelta, Carlos Gómez Sánchez-Lafuente, Daniel Hernández Huerta, Daniel Núñez Arias, Beatriz Oda Plasencia-García, Carlos Parro Torres, Samuel Leopoldo Romero-Guillena, Elena Ros Cucurul, Cecilio Alamo
Abstract Objectives Aripiprazole is an antipsychotic with a partial agonism of dopamine D2 and D3 receptors. This differential mechanism implies a rigorous appraisal of the appropriate therapeutic strategies in certain situations. To answer currently unsolved clinical questions about the use of oral and long-acting injectable (LAI) aripiprazole, we present here an expert consensus from 12 Spanish psychiatrists
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Associations of dysfunctional attitudes, ruminations and metacognitive beliefs about rumination with pharmacological treatment response in patients with first episode of major depression Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-24 İlker Özben, Güliz Şenormancı, Onur Okan Demirci, Ömer Şenormancı
Abstract Introduction The aim of this study is to investigate whether treatment with selective serotonin reuptake inhibitors (SSRI) has an effect on the ruminative response, ruminative beliefs and dysfunctional attitudes (DA), and to evaluate the effects of pre-treatment dysfunctional attitudes and rumination levels on treatment response in individuals diagnosed with the first episode of major depression
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Subthreshold depression – concept, operationalisation and epidemiological data. A scoping review Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-23 Hans-Peter Volz, Johanna Stirnweiß, Siegfried Kasper, Hans-Jürgen Möller, Erich Seifritz
Abstract Purpose In diagnostic systems (e.g., DSM-5, ICD-10), depression is defined categorically. However, the concept of subthreshold depression (SD) has gained increasing interest in recent years. The purpose of the present paper was to review, based on a scoping review, the relevant papers in this field published between October 2011 and September 2020. Materials and methods Of the 1,160 papers
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Validation of the Turkish version of the self-evaluation of negative symptoms scale (SNS) Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-14 Irmak Polat, Ezgi Ince Guliyev, Sibel Elmas, Sufiya Karakaş, Ömer Aydemir, Alp Üçok
Abstract Objectives The Self-Evaluation of Negative Symptoms Scale (SNS) is a self-report scale that evaluates a patient’s subjective experience on all five domains of the negative symptoms. This study aimed to present the adaptation and validation study of the Turkish version of SNS(SNS-TR). Methods Seventy-five patients and 50 controls were recruited for this study. After the approval of the translation
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The effects of the COVID-19 pandemic on patients with obsessive-compulsive disorder Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-04 Raşit Tükel, Oğuzhan Başaran, Simge Ergün, Mourat Giousouf Chousein, Mesut Keskin, Erhan Ertekin
Abstract Objective Little is known about the impact of the COVID-19 pandemic on obsessive-compulsive disorder (OCD). The main aim of this study was to investigate how the pandemic has affected OCD patients and the relationship between the clinical features and the fear and obsession with COVID-19. Methods A total of 30 consecutive patients with OCD and 30 age-and sex-matched healthy controls were included
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Editorial 2 Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-03 Siegfried Kasper
Published in International Journal of Psychiatry in Clinical Practice (Vol. 26, No. 2, 2022)
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Impact of early use of long-acting injectable antipsychotics on functional outcome in first episode psychosis: a 3-year longitudinal study Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-06-02 Amal Abdel-Baki, Émile Poulin, Sofia Medrano, Paula Pires de Oliveira Padilha, Emmanuel Stip, Stéphane Potvin
Abstract Objectives To describe, in a naturalistic setting, the impact of the early use of LAI-AP on functional outcomes of early psychosis patients as compared to oral antipsychotics (OAP). Methods Longitudinal prospective 3-year naturalistic study of all consecutive admissions (n = 416) to two Early intervention services (EIS) for psychosis comparing baseline characteristics and the evolution of
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Unmet needs in the diagnosis and treatment of Parkinson’s disease psychosis and dementia-related psychosis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-05-14 Marwan Sabbagh, Gary W. Small, Stuart H. Isaacson, Yasar Torres-Yaghi, Fernando Pagan, Rajesh Pahwa
Abstract Dementia due to Parkinson’s disease and Alzheimer’s disease are associated with behavioural and psychological symptoms, including psychosis. Long-term management presents a challenge for health care providers and caregivers. Symptoms of psychosis include hallucinations and delusions; if untreated, these can lead to institutionalisation, decreased quality of life, and significant patient and
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Cariprazine for treating psychosis: an updated meta-analysis Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-05-11 Marcelo B. Generoso, Ivan Taiar, Quirino Cordeiro, Pedro Shiozawa, Siegfried Kasper
Abstract Purpose Early treatment of psychotic illness improves outcomes, reduces relapse rates and should not be delayed. Cariprazine is a promising antipsychotic drug and may be a valuable resource when clinicians are in doubt if psychotic symptoms are due to schizophrenia or bipolar disorder. Materials and Methods We conducted a systematic review and meta-analysis that included seven studies (n = 2896)
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The impact of obsessive-compulsive personality disorder in perfectionism Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-05-04 Sarah A. Redden, Nora E. Mueller, Jesse R. Cougle
Abstract Objective The construct of perfectionism has long been related to Obsessive-Compulsive Personality Disorder (OCPD), though research has not considered how OCPD could distinguish individuals with elevated perfectionism. The aim of this study was to evaluate clinical differences between those with and without OCPD in a sample of individuals with elevated perfectionism. Methods Seventy-four university
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Sociodemographic and clinical characteristics related with hyperprolactinaemia in psychiatric clinical population Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-04-26 D. A. Coronel, F. R. De la Peña, L. Palacios-Cruz, D. Cuevas, S. Duran
Abstract Background Hyperprolactinaemia (HyperPRL) induced by psychotropic drugs is a high-prevalence consequence which has repercussions in psychical and mental health in the psychiatric population, so this research had the objective to expand which sociodemographic and clinical features are associated with prolactin (PRL) elevation in patients treated with antidepressant and/or antipsychotic drugs
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‘Sleep and emotions: How much are they affected by confinement due to COVID-19? A longitudinal study’ Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-04-21 Estefanía Mónaco, Mar Zaragozá, Inmaculada Montoya-Castilla
Abstract Objective Our aim is to study changes in sleep and emotions in Spanish population during the confinement period due to first wave of COVID-19. Methods A total of 363 adults (69.4% women) aged between 18 and 65 (Mage = 32.59; SD = 12.57) participated in the study. Socio-demographics, sleep quality and emotional experience were evaluated. The study was longitudinal: a first data collection was
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General antidepressants prescribing trends 2009–2018 in Slovenia: a cross-sectional retrospective database study Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-04-13 Nanca Cebron Lipovec, Andrej Anderlic, Igor Locatelli
Abstract Background Antidepressants are one of the most frequently prescribed groups of medications. The aim of the study was to evaluate the prevalence and patterns of antidepressants prescribed between 2009 and 2018 in Slovenia in different patient-age groups. Methods This retrospective cross-sectional study performed a nationwide database analysis of all outpatient antidepressant prescriptions based
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Sick leave duration as a potential marker of functionality and disease severity in depression Int. J. Psychiatry Clin. Pract. (IF 3.0) Pub Date : 2022-04-02 Hans-Peter Volz, Elis Bartečků, Lucie Bartova, João Bessa, Domenico De Berardis, Jozef Dragasek, Hristo Kozhuharov, Maria Ladea, Judit Lazáry, Miquel Roca, Grigory Usov, Adam Wichniak, Brian Godman, Siegfried Kasper
Abstract Objective: To discuss the impact of depression on work and how depression-related sick leave duration could be a potential indicator and outcome for measuring functionality in depression. Methods: Our review was based on a literature search and expert opinion that emerged during a virtual meeting of European psychiatrists that was convened to discuss this topic. Results: Current evidence demonstrates