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Clinical outcomes with paliperidone palmitate 3-monthly injection as monotherapy: observational 3-year follow-up of patients with schizophrenia Eur. Psychiatry (IF 7.8) Pub Date : 2024-03-07 Ivana Clark, Phoebe Wallman, Siobhan Gee, David Taylor
Background Paliperidone palmitate 3-monthly (PP3M) has been tested in 1-year controlled studies. The aim of this study was to examine the relapse outcomes with PP3M monotherapy at 3 years in patients with schizophrenia.Methods This was an observational, non-interventional study of patients started on PP3M according to their clinical need. All patients had a diagnosis of schizophrenia (ICD-10 F20) and
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Prenatal maternal PTSD as a risk factor for offspring ADHD: A register-based Swedish cohort study of 553 766 children and their mothers Eur. Psychiatry (IF 7.8) Pub Date : 2024-03-01 Michael Borgert, Amandah Melin, Anna-Clara Hollander, Syed Rahman
Background Attention-deficit hyperactivity disorder (ADHD) is highly heritable, though environmental factors also play a role. Prenatal maternal stress is suggested to be one such factor, including exposure to highly distressing events that could lead to post-traumatic stress disorder (PTSD). The aim of this study is to investigate whether prenatal maternal PTSD is associated with offspring ADHD.Method
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The risk of antidepressant-induced hyponatremia: A meta-analysis of antidepressant classes and compounds Eur. Psychiatry (IF 7.8) Pub Date : 2024-02-26 Tim Gheysens, Filip Van Den Eede, Livia De Picker
Background Hyponatremia (hypoNa) is a potentially serious adverse event of antidepressant treatment. Previous research suggests the risk of drug-induced hyponatremia differs between antidepressants. This meta-analysis sought to determine the risk of antidepressant-induced hypoNa, stratified by different compounds and classes.Methods A PRISMA-compliant systematic search of Web of Science and PubMed
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Shortening the Alzheimer’s disease assessment scale cognitive subscale Eur. Psychiatry (IF 7.8) Pub Date : 2024-02-23 Stephen Z. Levine, Yair Goldberg, Anat Rotstein, Myrto Samara, Kazufumi Yoshida, Andrea Cipriani, Takeshi Iwatsubo, Stefan Leucht, Toshiaki A. Furukawa
Background A short yet reliable cognitive measure is needed that separates treatment and placebo for treatment trials for Alzheimer’s disease. Hence, we aimed to shorten the Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) and test its use as an efficacy measure.Methods Secondary data analysis of participant-level data from five pivotal clinical trials of donepezil compared with placebo
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Effects of psychedelic microdosing versus conventional ADHD medication use on emotion regulation, empathy, and ADHD symptoms in adults with severe ADHD symptoms: A naturalistic prospective comparison study Eur. Psychiatry (IF 7.8) Pub Date : 2024-02-14 Eline C.H.M. Haijen, Petra P.M. Hurks, Kim P.C. Kuypers
Adults with attention-deficit hyperactivity disorder (ADHD) often struggle with emotion regulation (ER), impacting their empathic skills and relationships. ADHD medication might not be as effective for ER issues as for ADHD symptoms. Microdosing (MD) psychedelics has shown promise for ADHD treatment and previous studies reported social-emotional benefits. Two online prospective studies investigated
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Restoration of postictal cortical activity after electroconvulsive therapy relates to recovery of orientation in person, place, and time Eur. Psychiatry (IF 7.8) Pub Date : 2024-02-14 Sven Stuiver, Julia C.M. Pottkämper, Joey P.A.J. Verdijk, Freek ten Doesschate, Michel J.A.M. van Putten, Jeannette Hofmeijer, Jeroen A. van Waarde
Background Most patients show temporary impairments in clinical orientation after electroconvulsive therapy (ECT)-induced seizures. It is unclear how postictal reorientation relates to electroencephalography (EEG) restoration. This relationship may provide additional measures to quantify postictal recovery and shed light on neurophysiological aspects of reorientation after ECT.Methods We analyzed prospectively
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Cognitive and mental health trajectories of COVID-19: Role of hospitalisation and long-COVID symptoms Eur. Psychiatry (IF 7.8) Pub Date : 2024-02-05 Krupa Vakani, Martina Ratto, Anna Sandford-James, Elena Antonova, Veena Kumari
Background There is considerable evidence of cognitive impairment post COVID-19, especially in individuals with long-COVID symptoms, but limited research objectively evaluating whether such impairment attenuates or resolves over time, especially in young and middle-aged adults.Methods Follow-up assessments (T2) of cognitive function (processing speed, attention, working memory, executive function,
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Feeling better? – Identification, interventions, and remission among women with early postpartum depressive symptoms in Sweden: a nested cohort study Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-23 Karin Gidén, Lisa Vinnerljung, Stavros I. Iliadis, Emma Fransson, Alkistis Skalkidou
Background Postpartum depression affects around 12% of mothers in developed countries, with consequences for the whole family. Many women with depressive symptoms remain undetected and untreated. The aim of this study was to investigate to what extent women with depressive symptoms at 6 weeks postpartum are identified by the healthcare system, the interventions they received, and remission rates at
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The effects of antipsychotic discontinuation or maintenance on the process of recovery in remitted first-episode psychosis patients – A systematic review and meta-analysis of randomized controlled trials Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-22 Laurent Béchard, Charles Desmeules, Lauryann Bachand, Maxime Huot-Lavoie, Olivier Corbeil, Elizabeth Anderson, Sébastien Brodeur, Annie LeBlanc, Marie-France Demers, Sophie Lauzier, Marc-André Roy
Background The optimal duration of antipsychotic treatment following remission of first-episode psychosis (FEP) is uncertain, considering potential adverse effects and individual variability in relapse rates. This study aimed to investigate the effect of antipsychotic discontinuation compared to continuation on recovery in remitted FEP patients.Methods CENTRAL, MEDLINE (Ovid), Embase, and PsycINFO
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Maternal type 1 diabetes, preterm birth, and risk of intellectual disability in the offspring: A nation-wide study in Sweden Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-22 Martina Persson, Kristina Tedroff, Weiyao Yin, Mikael Andersson Franko, Sven Sandin
Objective There are few data on long-term neurological or cognitive outcomes in the offspring of mothers with type 1 diabetes (T1D). The aims of this study were to examine if maternal T1D increases the risk of intellectual disability (ID) in the offspring, estimate the amount of mediation through preterm birth, and examine if the association was modified by maternal glycated hemoglobin (HbA1c).Design
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Suicides in degenerative neurocognitive disorders and traumatic brain injuries Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-17 Tiina Talaslahti, Milena Ginters, Anniina Palm, Hannu Kautiainen, Risto Vataja, Henrik Elonheimo, Jaana Suvisaari, Hannu Koponen, Nina Lindberg
Background Neuropsychiatric symptoms in major neurocognitive disorders have been strongly associated with suicidality.Methods The objectives were to explore suicide rates in degenerative neurocognitive disorders (DNDs), alcohol-related neurocognitive disorders (ARNDs), and traumatic brain injuries (TBIs). Patients who received these diagnoses between 1998 and 2015 (N = 231,817) were identified from
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Suicide in the press: an analysis of newspaper coverage of adolescent versus adult suicides in Italy Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-17 Chiara Davico, Luca Arletti, Giulia Silverio, Daniele Marcotulli, Federica S. Ricci, Federico Amianto, Benedetto Vitiello
Background An association between sensationalized media reporting and subsequent increase in suicidal behavior has been documented, and adolescents are especially vulnerable to imitative influences. The aims of this study were to examine the characteristics of the articles reporting adult and adolescent (under age 18) suicides in the Italian press and to assess adherence to the World Health Organization
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Unmasking patient diversity: Exploring cognitive and antidepressive effects of electroconvulsive therapy Eur. Psychiatry (IF 7.8) Pub Date : 2024-01-12 Kjersti Sellevåg, Christoffer A. Bartz-Johannessen, Ketil J. Oedegaard, Axel Nordenskjöld, Christine Mohn, Jeanette S. Bjørke, Ute Kessler
Background Electroconvulsive therapy (ECT) is an established treatment for depression, but more data on effectiveness and safety in clinical practice is needed. The aim of this register-based study was to investigate short-term effectiveness and cognitive safety after ECT, evaluated by clinicians and patients. Secondary, we investigated predictors for remission and cognitive decline.Methods The study
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External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-15 Giulia M. Giordano, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Francesco Brando, Edoardo Caporusso, Luigi Giuliani, Antonio Melillo, Pasquale Pezzella, Paola Bucci, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Rodolfo Rossi, Giulio Pergola, Silvana Galderisi, Mario Maj, Italian Network for Research on Psychoses
Background The conceptualization of negative symptoms (NS) in schizophrenia is still controversial. Recent confirmatory factor-analytic studies suggested that the bi-dimensional model (motivational deficit [MAP] and expressive deficit [EXP]) may not capture the complexity of NS structure, which could be better defined by a five-factor (five NS domains) or a hierarchical model (five NS domains as first-order
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The new European Medicines Agency guideline on antidepressants: a guide for researchers and drug developers Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-15 Florence Butlen-Ducuing, Marion Haberkamp, Georgios Aislaitner, Ewa Bałkowiec-Iskra, Taina Mattila, Marika Doucet, Marta Kollb-Sielecka, Pavel Balabanov, Ann-Kristin Leuchs, André Elferink
According to the World Health Organization (WHO), depressive disorders are currently considered as one of the most disabling medical conditions in the world with one of the highest disability-adjusted life years [1] and this situation has apparently been further worsened during the COVID-19 pandemic [2]. Up to two thirds of patients with major depressive disorders (MDD) do not achieve full remission
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Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-13 Nathan Risch, Jonathan Dubois, Bruno Etain, Bruno Aouizerate, Frank Bellivier, Raoul Belzeaux, Caroline Dubertret, Emmanuel Haffen, Dominique Januel, Marion Leboyer, Antoine Lefrere, Ludovic Samalin, Mircea Polosan, Romain Rey, Paul Roux, Raymund Schwan, Michel Walter, FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators, Philippe Courtet, Emilie Olié
Background Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain.Methods This naturalistic study included 760 subjects with BD ( FACE-BD cohort) divided in two groups: with
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Association of clinical symptoms and cardiometabolic dysregulations in patients with schizophrenia spectrum disorders Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-13 Chenxu Zhao, Tesfa Dejenie Habtewold, Elnaz Naderi, Edith J. Liemburg, GROUP Investigators, Richard Bruggeman, Behrooz Z. Alizadeh
Background Patients with schizophrenia spectrum disorders (SSD) have a shortened life expectancy related to cardiovascular diseases. We investigated the association of cognitive, positive, and negative symptoms with cardiometabolic dysregulations in SSD patients.Methods Overall, 1,119 patients from the Genetic Risk and Outcome in Psychosis (GROUP) study were included. Cognitive function, positive and
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Digitalising mental health care: Practical recommendations from the European Psychiatric Association Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-13 Janos L. Kalman, Gerrit Burkhardt, Jerzy Samochowiec, Christian Gebhard, Geert Dom, Miriam John, Ozge Kilic, Tamas Kurimay, Lars Lien, Meryam Schouler-Ocak, Diego Palao Vidal, Jan Wiser, Wolfgang Gaebel, Umberto Volpe, Peter Falkai
The digitalisation of mental health care is expected to improve the accessibility and quality of specialised treatment services and introduce innovative methods to study, assess, and monitor mental health disorders. In this narrative review and practical recommendation of the European Psychiatric Association (EPA), we aim to help healthcare providers and policymakers to navigate this rapidly evolving
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Complex association between post-COVID-19 condition and anxiety and depression symptoms Eur. Psychiatry (IF 7.8) Pub Date : 2023-12-13 Sarah Tebeka, Laure Carcaillon-Bentata, Valentina Decio, Caroline Alleaume, Nathalie Beltzer, Anne Gallay, Cédric Lemogne, Baptiste Pignon, Tatjana T. Makovski, Joël Coste
Background To assess the associations between anxiety and depressive symptoms and post-COVID-19 condition (PCC) by exploring the direction of these associations and their relevance in the definition of PCC.Methods Nationwide survey among French adults, recruited between March and April, 2022, using a quota method to capture a representative sample of the general population with regard to sex, age,
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Postmarket Safety Profile of Suicide/Self-injury for GLP-1 Receptor Agonist: A Real-World Pharmacovigilance Analysis. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-30 Congqin Chen,Rijing Zhou,Fang Fu,Jie Xiao
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Psychosocial interventions for carers of people with severe mental and substance use disorders: A systematic review and meta-analysis. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-24 Gaia Sampogna,Elaine Brohan,Mario Luciano,Neerja Chowdhary,Andrea Fiorillo
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A systematic meta-review of systematic reviews on attention deficit hyperactivity disorder. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-17 Ashmita Chaulagain,Ingvild Lyhmann,Anne Halmøy,Tarjei Widding-Havneraas,Olav Nyttingnes,Ingvar Bjelland,Arnstein Mykletun
BACKGROUND There are now hundreds of systematic reviews on attention deficit hyperactivity disorder (ADHD) of variable quality. To help navigate this literature, we have reviewed systematic reviews on any topic on ADHD. METHODS We searched MEDLINE, PubMed, PsycINFO, Cochrane Library, and Web of Science and performed quality assessment according to the Joanna Briggs Institute Manual for Evidence Synthesis
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Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlates in gambling disorder. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-08 Isabel Baenas,Neus Solé-Morata,Roser Granero,Fernando Fernández-Aranda,Mitona Pujadas,Bernat Mora-Maltas,Ignacio Lucas,Mónica Gómez-Peña,Laura Moragas,Amparo Del Pino-Gutiérrez,Javier Tapia-Martínez,Rafael de la Torre,Marc N Potenza,Susana Jiménez-Murcia
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Have the psychiatric needs of people seeking gender reassignment changed as their numbers increase? A register study in Finland. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-06 Riittakerttu Kaltiala,Timo Holttinen,Katinka Tuisku
BACKGROUND The number of people seeking gender reassignment (GR) has increased everywhere and these increases particularly concern adolescents and emerging adults with female sex. It is not known whether the psychiatric needs of this population have changed alongside the demographic changes. METHODS A register-based follow-up study of individuals who contacted the nationally centralized gender identity
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Early intervention in psychosis services: A systematic review and narrative synthesis of barriers and facilitators to seeking access. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-06 Jacqui Tiller,Tess Maguire,Katherine Newman-Taylor
BACKGROUND The duration of untreated psychosis (DUP) continues to be a global priority. Early intervention services were established to reduce treatment delays but have had limited impact. This systematic review examines barriers and facilitators to seeking access to these services, to identify targets for service level change. METHODS We conducted a systematic review of relevant databases (PsychINFO
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Ethical dilemmas in contemporary psychiatry: findings from a survey of national psychiatric associations in Europe. Eur. Psychiatry (IF 7.8) Pub Date : 2023-11-01 Jerzy Samochowiec,Dorota Frydecka,Karolina Skonieczna-Żydecka,Meryam Schouler-Ocak,Bernardo Carpinello,Eka Chkonia,Geert Dom,Peter Falkai,Błażej Misiak,Mariana Pinto da Costa,Jan Wise,Livia de Picker,Simavi Vahip,Danuta Wasserman,Silvana Galderisi,Przemysław Bieńkowski
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Changes in anxiety and depression during the COVID-19 pandemic in the European population: A meta-analysis of changes and associations with restriction policies. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-26 Veeleah Lok,Hugo Sjöqvist,Anna Sidorchuk,Pär Flodin,Walter Osika,Michael Daly,Philip Hyland,Lars H Andersen,Peter Fallesen,Marcelo C Cabrera,Ann K S Knudsen,Karen Wetherall,Emily Widnall,Jenny M Groarke,Cherie Armour,Christina Dalman,Anna-Clara Hollander,Maria Niemi
BACKGROUND Early studies of common mental disorders (CMDs) during the COVID-19 pandemic mainly report increases; however, more recent findings have been mixed. Also, studies assessing the effects of restriction measures on CMDs show varied results. The aim of this meta-analysis was to assess changes in levels of CMDs from pre-/early to during the pandemic and the effects of restriction policies in
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Impact of the CoViD-19 pandemic on consultation-liaison activity: changes in everyday clinical practice and work-related factors associated with the psychiatrist's need for seeking help. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-26 Giorgio Mattei,Krzysztof Krysta,Massimo Clerici,Fabrizia Colmegna,Vladimir Korostiy,Dalibor Karlović,Marek Krzystanek,Gilbert M D Lemmens,Pieter-Jan Geerts,Filipa Novais,Vjekoslav Peitl,Jacopo Santambrogio,Dan Georgescu,Diogo Telles-Correia
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The role of mild stressors in children's cognition and inflammation: positive and negative impacts depend on timing of exposure. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-26 Marta Francesconi,Amedeo Minichino,Eirini Flouri
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Understanding the potential of digital therapies in implementing the standard of care for depression in Europe. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-24 Philippe Courtet,Odile Amiot,Enrique Baca-Garcia,Lara Bellardita,Giancarlo Cerveri,Anne-Hélène Clair,Diego De Leo,Dominique Drapier,Eric Fakra,Francis Gheysen,Lucas Giner,Ana Gonzalez-Pinto,Gualberto Gussoni,Emmanuel Haffen,Laurent Lecardeur,Fermin Mayoral-Cleries,Francesco Saverio Mennini,Pilar A Sáiz,Eduard Vieta,Diego Alberto Hidalgo,Umberto Volpe
Depressive disorders represent the largest proportion of mental illnesses, and by 2030, they are expected to be the first cause of disability-adjusted life years [1]. The COVID-19 pandemic exacerbated prevalence and burden of depression and increased the occurrence of depressive symptoms in general population [2]. The urgency of implementing mental health services to address new barriers to care persuaded
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Autistic symptoms in unaffected first-degree relatives of people with schizophrenia: results from the Italian Network for Research on Psychoses multicenter study. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-23 Antonio Vita,Stefano Barlati,Giacomo Deste,Alessandro Rossi,Paola Rocca,Alessandro Bertolino,Eugenio Aguglia,Carlo A Altamura,Mario Amore,Antonello Bellomo,Paola Bucci,Bernardo Carpiniello,Alessandro Cuomo,Liliana Dell'Osso,Luigi Giuliani,Carlo Marchesi,Giovanni Martinotti,Palmiero Monteleone,Cristiana Montemagni,Gabriele Nibbio,Massimo Pasquini,Maurizio Pompili,Antonio Rampino,Rita Roncone,Rodolfo
BACKGROUND Autistic symptoms represent a frequent feature in schizophrenia spectrum disorders (SSD). However, the prevalence and the cognitive and functional correlates of autistic symptoms in unaffected first-degree relatives of people with SSD remain to be assessed. METHODS A total of 342 unaffected first-degree relatives related to 247 outpatients with schizophrenia were recruited as part of the
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Toward recovery-oriented perinatal healthcare: A participatory qualitative exploration of persons with lived experience and health providers' views and experiences. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-20 Marine Dubreucq,Mathilde Thiollier,Sarah Tebeka,Pierre Fourneret,Marion Leboyer,Sylvie Viaux-Savelon,Catherine Massoubre,Corinne Dupont,Julien Dubreucq
BACKGROUND Perinatal mental health disorders (PMHD) remain often undetected, undiagnosed, and untreated with variable access to perinatal mental health care (PMHC). To guide the design of optimal PMHC (i.e., coproduced with persons with lived experience [PLEs]), this qualitative participatory study explored the experiences, views, and expectations of PLEs, obstetric providers (OP), childcare health
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Orbitofrontal sulcal patterns in catatonia Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-19 Mylène Moyal, Alexandre Haroche, David Attali, Ghita Dadi, Matthieu Raoelison, Alice Le Berre, Anton Iftimovici, Boris Chaumette, Sylvain Leroy, Sylvain Charron, Clément Debacker, Catherine Oppenheim, Arnaud Cachia, Marion Plaze
Background Catatonia is a psychomotor syndrome frequently observed in disorders with neurodevelopmental impairments, including psychiatric disorders such as schizophrenia. The orbitofrontal cortex (OFC) has been repeatedly associated with catatonia. It presents with an important interindividual morphological variability, with three distinct H-shaped sulcal patterns, types I, II, and III, based on the
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Impulsivity and compulsivity in gambling disorder and bulimic spectrum eating disorders: Analysis of neuropsychological profiles and sex differences. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-19 María Lozano-Madrid,Roser Granero,Ignacio Lucas,Isabel Sánchez,Jéssica Sánchez-González,Mónica Gómez-Peña,Laura Moragas,Nuria Mallorquí-Bagué,Javier Tapia,Susana Jiménez-Murcia,Fernando Fernández-Aranda
BACKGROUND Gambling disorder (GD) and bulimic spectrum eating disorders (BSDs) not only share numerous psychopathological, neurobiological, and comorbidity features but also are distinguished by the presence of inappropriate behaviours related to impulsivity and compulsivity. This study aimed to emphasise the differences and similarities in the main impulsivity and compulsivity features between GD
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If you feel you can't, you won't: the role of subjective and objective cognitive competence on psychosocial functioning in depression. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-19 Muriel Vicent-Gil,Joan Trujols,Maria Serra-Blasco,Guillem Navarra-Ventura,Dolors Puigdemont,Carlo Alemany,Sara Crivillés,Javier de Diego-Adeliño,Narcís Cardoner,Maria J Portella
BACKGROUND The purpose of this exploratory study is to examine the role of sociodemographic, clinical, and cognitive - both objective and subjective - factors in overall and in specific domains of psychosocial functioning, in patients with depression at different clinical states of the disease (remitted and non-remitted). METHODS A sample of 325 patients with major depressive disorder, 117 in remission
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Exploring the complex relationships between coping strategies, locus of control and self-esteem with psychopathology: structural equation modeling with a special focus on clinical high-risk of psychosis. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-18 Giulia Rinaldi,Naweed Osman,Michael Kaess,Benno G Schimmelmann,Jochen Kindler,Frauke Schultze-Lutter,Chantal Michel
BACKGROUND Coping strategies, competence, and locus of control (LOC) beliefs are important predictors of mental health (MH). However, research into their complex interactions has produced mixed results. Our study investigated them further in the previously unexplored context of clinical high-risk (CHR) of psychosis. METHODS We tested six alternative structural equation models in a community sample
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Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-18 Jesus Pujol,Nuria Pujol,Anna Mané,Gerard Martínez-Vilavella,Joan Deus,Víctor Pérez-Sola,Laura Blanco-Hinojo
BACKGROUND Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia. GABA interneuron deficiency is locally expressed in the form of neural activity desynchronization. We mapped the functional anatomy of local synchrony in the
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The role of gender as a barrier to the professional development of psychiatrists. Eur. Psychiatry (IF 7.8) Pub Date : 2023-10-18 Ozge Kilic,Anita Riecher-Rössler,Silvana Galderisi,Philip Gorwood,Sophia Frangou,Mariana Pinto da Costa
BACKGROUND Despite efforts toward greater gender equality in clinical and academic psychiatry in recent years, more information is needed about the challenges in professional development within psychiatry, and how these may vary with gender. METHODS A cross-sectional 27-item online survey was conducted with psychiatrists and psychiatric trainee members of the European Psychiatric Association. RESULTS
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Body mass index on perinatal depression: A critical viewpoint. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-29 David F Lo,Jaylyn Thompson
I am pleased to submit a viewpoint titled "Body mass index on perinatal depression: A critical viewpoint" in response to an article by Ventriglio et al. titled, "The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study" for consideration for publication in your journal.
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Mediation effect of anxious attachment on relationship between childhood trauma and suicidal ideation sensitive to psychological pain levels. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-22 Hannah Ihme,Philippe Courtet,Nathan Risch,Jonathan Dubois,Raoul Belzeaux,Emilie Olié
BACKGROUND Childhood trauma (CT), depression, and psychological pain are known predictors of suicidal ideation. Recent literature additionally highlights the importance of the attachment system. METHODS We aimed to predict suicidal ideation through CT, attachment, and psychological and social pain by using mediation models aiming to predict suicidal ideation through CT (predictor) and attachment (mediator)
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Economic analysis of early intervention for autistic children: findings from four case studies in England, Ireland, Italy, and Spain. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-21 Michela Tinelli,Aine Roddy,Martin Knapp,Celso Arango,Maria Andreina Mendez,James Cusack,Declan Murphy,Roberto Canitano,Bethany Oakley,Vinciane Quoidbach
BACKGROUND Many autistic children experience difficulties in their communication and language skills development, with consequences for social development into adulthood, often resulting in challenges over the life-course and high economic impacts for individuals, families, and society. The Preschool Autism Communication Trial (PACT) intervention is effective in terms of improved social communication
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A comprehensive evaluation of adverse childhood experiences, social-emotional impairments, and neurodevelopmental disorders in cannabis-use disorder: Implications for clinical practice. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-13 Giada Trovini,Emanuela Amici,Piergiorgio Bauco,Marta Matrone,Ginevra Lombardozzi,Valeria Giovanetti,Georgios D Kotzalidis,Sergio De Filippis
BACKGROUND Adverse childhood experiences (ACEs), social-emotional impairments (SEIs), and neurodevelopmental disorders (NDs) are frequent in psychiatric disorders, including substance-use disorders. We aimed to determine the prevalence of ACE, SEI, or ND in individuals with cannabis-use disorder (CUD). We compared individuals with preCUD-onset ACE, SEI, or ND to those without. METHODS We crosssectionally
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Dissociation between neuroanatomical and symptomatic subtypes in schizophrenia. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-13 Chao Chai,Hao Ding,Xiaotong Du,Yingying Xie,Weiqi Man,Yu Zhang,Yi Ji,Meng Liang,Bin Zhang,Yuping Ning,Chuanjun Zhuo,Chunshui Yu,Wen Qin
BACKGROUND Schizophrenia is a complex and heterogeneous syndrome with high clinical and biological stratification. Identifying distinctive subtypes can improve diagnostic accuracy and help precise therapy. A key challenge for schizophrenia subtyping is understanding the subtype-specific biological underpinnings of clinical heterogeneity. This study aimed to investigate if the machine learning (ML)-based
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Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-12 Dong Yun Lee,Carmen Andreescu,Howard Aizenstein,Helmet Karim,Akiko Mizuno,Antonija Kolobaric,Seokyoung Yoon,Yerim Kim,Jaegyun Lim,Ein Jeong Hwang,Yung-Taek Ouh,Hyung Hoi Kim,Sang Joon Son,Rae Woong Park
BACKGROUND The menopause transition is a vulnerable period that can be associated with changes in mood and cognition. The present study aimed to investigate whether a symptomatic menopausal transition increases the risks of depression, anxiety, and sleep disorders. METHODS This population-based, retrospective cohort study analysed data from five electronic health record databases in South Korea. Women
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Are anxious and mixed depression two sides of the same coin? Similarities and differences in patients with bipolar I, II and unipolar disorders. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-12 Antonio Tundo,Laura Musetti,Sophia Betrò,Erika Cambiali,Rocco de Filippis,Donatella Marazziti,Federico Mucci,Luca Proietti,Liliana Dell'Osso
BACKGROUND Diagnostic criteria are not always useful to discriminate major depression with anxious distress (ADS-D; Diagnostic and Statistical Manual for Mental Disorders, version-5 [DSM-5] criteria) from mixed depression (Koukopoulos' criteria; KMX-D). So, clinicians need alternative tools to improve their diagnostic ability and to choose the most appropriate treatment. The aim of the present study
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Potential neuropsychological mechanism involved in the transition from suicide ideation to action - a resting-state fMRI study implicating the insula. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-11 Shulin Fang,Samuel F Law,Xinlei Ji,Qinyu Liu,Panwen Zhang,Runqing Zhong,Huanhuan Li,Xiaosheng Wang,Shuqiao Yao,Xiang Wang
BACKGROUND Understanding the neural mechanism underlying the transition from suicidal ideation to action is crucial but remains unclear. To explore this mechanism, we combined resting-state functional connectivity (rsFC) and computational modeling to investigate differences between those who attempted suicide(SA) and those who hold only high levels of suicidal ideation(HSI). METHODS A total of 120
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Premature termination, satisfaction with care, and shared decision-making during home treatment compared to inpatient treatment: A quasi-experimental trial. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-08 Stefan Weinmann,Konstantinos Nikolaidis,Gerhard Längle,Sebastian von Peter,Peter Brieger,Jürgen Timm,Lasse Fischer,Svenja Raschmann,Martin Holzke,Julian Schwarz,Luisa Klocke,Sandeep Rout,Constanze Hirschmeier,Uwe Herwig,Janina Richter,Reinhold Kilian,Johanna Baumgardt,Johannes Hamann,Andreas Bechdolf
BACKGROUND Inpatient equivalent home treatment (IEHT), implemented in Germany since 2018, is a specific form of home treatment. Between 2021 and 2022, IEHT was compared to inpatient psychiatric treatment in a 12-months follow-up quasi-experimental study with two propensity score matched cohorts in 10 psychiatric centers in Germany. This article reports results on the treatment during the acute episode
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Viewpoint: Difficult-to-treat depression versus treatment-resistant depression: A new integrative perspective for managing depression. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-08 Walter Paganin
In the STAR*D study, the efficacy of treatments for major depression was examined. It was found that, while many responded to the initial antidepressant treatment, only 30% of participants achieved complete remission. Concerning treatment resistance in depression, there is a recent distinction emerging between treatment-resistant depression (TRD) and difficult-to-treat depression (DTD). Historically
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The curse of experiencing and committing violence as a criminal recidivism predictor: A comparison between female forensic psychiatric patients with severe mental disorders and substance use disorder. Eur. Psychiatry (IF 7.8) Pub Date : 2023-09-04 Michael Fritz,Georgios Karanassios,Viviane Wolf,Juliane Mayer,Ivonne Steiner,Irina Franke,Verena Klein,Judith Streb,Manuela Dudeck
BACKGROUND Violence occurs frequently in the life of forensic psychiatric patients, both as active aggression and in the form of victimization. Undoubtedly, these incidents shape personality, behavior, and affect the ability to interact adequately socially. Thus, such experiences may influence criminal recidivism and serve as forensic psychiatric/psychological predictors upon hospital discharge. METHODS
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How come Denmark is planning to increase the annual budget for psychiatry by almost 20 percent? Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-16 Merete Nordentoft,Mikkel Rasmussen,Lene Høgh,Christian Legind,Jakob Kjellberg
In Denmark, a 10-year plan for psychiatry has been agreed on. The content of the plan was developed in collaboration between the Danish Health Authority and the Danish Authority for Social Services and Housing, and it involved many stakeholders. Recently, the government presented a planned investment that would increase the overall budget in Danish regions and municipalities by almost 20 percent over
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Physical health disparities and severe mental illness: A longitudinal comparative cohort study using hospital data in Northern Ireland. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-14 Rachel McCarter,Michael Rosato,Annette Thampi,Ruth Barr,Gerard Leavey
BACKGROUND People with severe mental illness (SMI) die prematurely, mostly due to preventable causes. OBJECTIVE To examine multimorbidity and mortality in people living with SMI using linked administrative datasets. METHOD Analysis of linked electronically captured routine hospital administrative data from Northern Ireland (2010-2021). We derived sex-specific age-standardised rates for seven chronic
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Dose-tapering trajectories in patients with remitted psychosis undergoing guided antipsychotic reduction to reach minimum effective dose. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-14 Chen-Chung Liu,Ming H Hsieh,Yi-Ling Chien,Chih-Min Liu,Yi-Ting Lin,Tzung-Jeng Hwang,Hai-Gwo Hwu
BACKGROUND Patients with remitted psychosis wish to reduce antipsychotic doses yet facing increased risks of relapse. Examining dose-tapering processes may provide insights to re-evaluate the risk-to-benefit balance. We aimed to depict and subgroup tapering trajectories, and explore factors associated with different dose-reduction patterns. METHODS A 2-year open-label randomized prospective comparative
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Viewpoint: Assessing the value of mental health treatments in Europe. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-09 Judit Simon,Patrice Boyer,Jose M Caldas-de-Almeida,Martin Knapp,Paul McCrone,Philip Gorwood,Wolfgang Oertel,Celso Arango,Janet Treasure,Allan H Young,Frederic Destrebecq,Vinciane Quoidbach
One in eight individuals worldwide lives with a mental health disorder. For many European countries, the prevalence is even higher, with one in four people reporting mental health problems [1]. Three-quarters of all mental health disorders develop before age 25, with many presenting initially in undiagnosed forms already in the mid-teens and eventually manifesting as severe disorders and lasting into
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Moment-to-moment affective dynamics in schizophrenia and bipolar disorder. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-07 Suzanne Ho-Wai So,Anson Kai Chun Chau,Lawrence Kin-Hei Chung,Chung-Ming Leung,George H C Chong,Wing Chung Chang,Arthur D P Mak,Sandra S M Chan,Sing Lee,Iris E Sommer
BACKGROUND Affective disturbances in schizophrenia and bipolar disorder may represent a transdiagnostic etiological process as well as a target of intervention. Hypotheses on similarities and differences in various parameters of affective dynamics (intensity, successive/acute changes, variability, and reactivity to stress) between the two disorders were tested. METHODS Experience sampling method was
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Does the use of pharmacotherapy interact with the effects of psychotherapy? A meta-analytic review. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-03 Pim Cuijpers,Clara Miguel,Mathias Harrer,Marketa Ciharova,Eirini Karyotaki
BACKGROUND It is not clear if there is an interaction between psychotherapy and pharmacotherapy. First, there may be no interaction at all, meaning that the effects of both are independent of each other. Second, antidepressants may reduce the effects of psychotherapy, and third, antidepressants may increase the effects of psychotherapy. We examined which of the three is correct. METHODS We conducted
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Improving mental health care in depression: A call for action. Eur. Psychiatry (IF 7.8) Pub Date : 2023-08-03 Julia Eder,Geert Dom,Philip Gorwood,Hikka Kärkkäinen,Andre Decraene,Ulrike Kumpf,Julian Beezhold,Jerzy Samochowiec,Tamas Kurimay,Wolfgang Gaebel,Livia De Picker,Peter Falkai
Depressive disorders have one of the highest disability-adjusted life years (DALYs) of all medical conditions, which led the European Psychiatric Association to propose a policy paper, pinpointing their unmet health care and research needs. The first part focuses on what can be currently done to improve the care of patients with depression, and then discuss future trends for research and healthcare
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Functional improvement by behavioural activation for depressed older adults. Eur. Psychiatry (IF 7.8) Pub Date : 2023-07-27 Noortje P Janssen,Richard C Oude Voshaar,Sanne Wassink-Vossen,Gert-Jan Hendriks
BACKGROUND Recovery in mental health care comprises more than symptomatic improvement, but preliminary evidence suggests that only collaborative care may improve functioning of depressed older adults. This study therefore evaluates the effectiveness of behavioural activation (BA) on functional limitations in depressed older adults in primary care. METHODS This study uses data from a multicentre cluster
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The cost-utility of a return-to-work intervention in comparison to routine care for patients with mental disorders in Germany: Results from the RETURN project. Eur. Psychiatry (IF 7.8) Pub Date : 2023-07-24 Tamara Waldmann,Lina Riedl,Peter Brieger,Anne Lang,Daniela Blank,Monika Kohl,Adele Brucks,Markus Bühner,Johannes Hamann,Reinhold Kilian
BACKGROUND Only two-thirds of patients admitted to psychiatric wards return to their previous jobs. Return-to-work interventions in Germany are investigated for their effectiveness, but information regarding cost-effectiveness is lacking. This study investigates the cost-utility of a return-to-work intervention for patients with mental disorders compared to treatment as usual (TAU). METHODS We used
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The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia. Eur. Psychiatry (IF 7.8) Pub Date : 2023-07-21 Błażej Misiak,Jerzy Samochowiec,Krzysztof Kowalski,Wolfgang Gaebel,Claudio L A Bassetti,Andrew Chan,Philip Gorwood,Sergi Papiol,Geert Dom,Umberto Volpe,Agata Szulc,Tamas Kurimay,Hilkka Kärkkäinen,Andre Decraene,Jan Wisse,Andrea Fiorillo,Peter Falkai
The ongoing developments of psychiatric classification systems have largely improved reliability of diagnosis, including that of schizophrenia. However, with an unknown pathophysiology and lacking biomarkers, its validity still remains low, requiring further advancements. Research has helped establish multiple sclerosis (MS) as the central nervous system (CNS) disorder with an established pathophysiology
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Autism with co-occurring epilepsy care pathway in Europe. Eur. Psychiatry (IF 7.8) Pub Date : 2023-07-20 Maria A Mendez,Roberto Canitano,Bethany Oakley,Antonia San José-Cáceres,Michela Tinelli,Martin Knapp,James Cusack,Mara Parellada,Pierre Violland,Jan R Derk Plas,Declan G M Murphy,Vinciane Quoidbach,Celso Arango
BACKGROUND Autism and epilepsy often occur together. Epilepsy and other associated conditions have a substantial impact on the well-being of autistic people and their families, reduce quality of life, and increase premature mortality. Despite this, there is a lack of studies investigating the care pathway of autistic children with co-occurring epilepsy in Europe. METHODS We analyzed the care pathway