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The Impact of Psychological Burdens and Vaccine Worries on Confidence and Adherence to Governmental Policies Against COVID-19 Among Patients with Substance Use Disorder: A Cross-Sectional Study in Taiwan Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-12 Dian-Jeng Li, Joh-Jong Huang, Su-Ting Hsu, Hui-Ching Wu, Kuan-Ying Hsieh, Guei-Ging Lin, Pei-Jhen Wu, Chin-Lien Liu, Frank Huang-Chih Chou
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has had an impact on patients with substance use disorder (SUD). We aimed to investigate factors associated with confidence and adherence to governmental policies against COVID-19 (social desirability) among patients with SUD. Methods: This cross-sectional study was conducted during 2020 to 2021. Patients with SUD and healthy controls were
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Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-12 Maj Vinberg, Roger S McIntyre, Annamaria Giraldi, Klara Coello
Abstract: The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine
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Neural Correlates of Cognitive Dysfunction in Conditional Reasoning in Schizophrenia: An Event-related Potential Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-11 Chang Chen, Qian Mei, Qi Liu, Meichen Lu, Lu Hou, Xiaohong Liu, Xuezheng Gao, Limin Chen, Zhenhe Zhou, Hongliang Zhou
Purpose: Schizophrenia patients show impaired conditional reasoning. This study was to investigate event-related potential (ERP) characteristics of the conditional reasoning in schizophrenia. Patients and methods: Participants included 24 schizophrenia patients and 30 normal controls (NCs), and the measurements of ERPs were conducted during the Wason selection task. Results: Results showed that NCs
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Social Stigma Toward Individuals with Schizophrenia in a Lebanese Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-08 Sana Ahmad Tantawi, Atifa Nazih Kamaleddine, Lama Ali Alhajj, Sondos Mohamad Naous, Nafez Nazih Kamaleddine, Seockhoon Chung, Sung Woo Joo
Background: Schizophrenia has been recognized as the most stigmatized mental disorder, imposing a substantial burden on affected individuals. However, no prior studies have investigated social stigma toward individuals with schizophrenia in Lebanon. Purpose: We aimed to examine three components of social stigma including knowledge, attitude, and behavior toward individuals with schizophrenia in a Lebanese
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The Impact of Integrating a Low-Lectin Diet with Traditional ADHD Treatments on Gut Microbiota Composition and Symptom Improvement in Children - A Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-09 Liying Long, Haiyan Peng, Xi Chen, Fei Wang, Wenjie Long, Ming Cheng, Jing Ma
Background and Purpose: This study aimed to investigate the impact of implementing a low-lectin diet on gut microbiota composition and symptom amelioration in pediatric patients diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methods: A total of 58 children (ages 7– 15 years), meeting the criteria for ADHD were recruited. In addition to standard medication treatment, participants in
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Effect of Surgical Masks and N95 Respirators on Anxiety Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-08 Yan Zhang, Qiongyao Yang, Qianru Ma, Yuanxiong Wu, Yue Wang, Chuanchuan Chen, Yitan Yao, Ziqiao Feng, Xiaoping Yuan, Shengya Shi, Kai Zhang
Purpose: Masks are designed to reduce the spread of airborne pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although wearing a mask has some adverse effects. The primary objective of this study was to explore the effects of surgical masks and N95 respirators on patients diagnosed with anxiety. Methods: Subjects diagnosed with first-episode anxiety disorders were recruited
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4-Hydroxysesamin, a Modified Natural Compound, Attenuates Neuronal Apoptosis After Ischemic Stroke via Inhibiting MAPK Pathway Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Lina Wang, Zhenzhen Qu, Qian Sun, Zhuofeng Mao, Peipei Si, Weiping Wang
Background: The 4-hydroxysesamin (4-HS, a di-tetrahydrofuran lignin) is a modified sesamin that was prepared in the laboratory. This preclinical study was designed to preliminarily investigate the neuroprotective properties of 4-HS. Methods: In vitro, neuronal injury and inflammation were simulated by oxygen-glucose deprivation and lipopolysaccharide (LPS) exposure in mouse hippocampal neuronal HT22
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Clinical Characteristics of Asymptomatic Thromboembolism in Psychiatric Inpatients: A Retrospective Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Yimeng Geng, Peifen Zhang, Yanmeng Pan, Huaizhi Wang, Yi Chen, Jianbo Lai, Shaohua Hu
Purpose: Venous thromboembolism (VTE) poses a significant threat to individuals’ health, yet its correlation with mental disorders remains underappreciated. Here, we conducted a retrospective analysis to explore the characteristics of psychiatric patients presenting with VTE. Methods: We retrospectively analyzed psychiatric inpatients with elevated plasma D-dimer levels at the Mental Health Center
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Improving Diagnostic Procedures in Autism for Girls and Women: A Narrative Review Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-07 Julia Cook, Laura Hull, Will Mandy
Abstract: Biases exist in the diagnostic process for autism spectrum disorder (henceforth “autism”), which result in some girls and women being diagnosed later or missed entirely. Current diagnostic tools may not capture the full range of behavioural presentations of autism, leading to under-identification. This review explores why these biases may occur, and how diagnostic procedures could be adapted
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Synapse-Related Serum and P300 Biomarkers Predict the Occurrence of Mild Cognitive Impairment in Depression Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-05 Zongwei Xue, Xiaoyan Zhu, Wenqi Wu, Yan Zhu, Yuhao Xu, Ming Yu
Background: Cognitive impairment is one of the common concomitant symptoms of depression. The aims of the present study were to predict the occurrence of mild cognitive impairment (MCI) in patients with depression. Methods: In this study, 217 patients with depression were recruited. Demographic data, serum indices and ERP indices from all participants were collected in the baseline period. The participants
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Validation and Functional Relevance of the Short Form of the Perceived Deficits Questionnaire for Depression for Japanese Patients with Major Depressive Disorder [Corrigendum] Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-06 Tomiki Sumiyoshi, Hiroyuki Uchida, Koichiro Watanabe, Masato Oosawa, Hongye Ren, Yoshiya Moriguchi, Keita Fujikawa, Jovelle Fernandez
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Effects of Aripiprazole on Olanzapine Population Pharmacokinetics and Initial Dosage Optimization in Schizophrenia Patients Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Cun Zhang, Lei Jiang, Ke Hu, Liang Chen, Yi-Jia Zhang, Hao-Zhe Shi, Su-Mei He, Xiao Chen, Dong-Dong Wang
Objective: Olanzapine has already been used to treat schizophrenia patients; however, the initial dosage recommendation when multiple drugs are used in combination, remains unclear. The purpose of this study was to explore the drug–drug interaction (DDI) of multiple drugs combined with olanzapine and to recommend the optimal administration of olanzapine in schizophrenia patients. Methods: In this study
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Severe Refractory Obsessive Compulsive Disorder and Depression: Should We Consider Stereotactic Neurosurgery? Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Ludvic Zrinzo
Abstract: Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as “standard of care”, benefiting hundreds of thousands of patients. As with movement disorders, some
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Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-04 Jun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi
Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS). Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children’s Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video
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Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-01 Wenpei Wu, Zhi Geng, Aimei Wu, Xinyi Chen, Xiaoying Meng, Qianyun Zhang, Zheng Tan, Hong Yue, Juncang Wu
Background and Purpose: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH). Methods: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference
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Investigating Factors Associated with the Development of Postnatal Depression After Cesarean Delivery: A Validation Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-29 Daryl Jian An Tan, Rehena Sultana, Sheryl Yu Xuan Chow, Chin Wen Tan, Hon Sen Tan, Helen Yu Chen, Tze-Ern Chua, Ban Leong Sng
Purpose: This study aimed to validate a proposed association model previously published to determine the clinical relevance of pre-operative determinants in the development of PND after Cesarean delivery (CD). Patients and Methods: Parturients undergoing elective CD under neuraxial anesthesia were recruited for a prospective cohort study between Oct 2021 and Oct 2022 at KK Women’s and Children’s Hospital
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Validity and Reliability Study of the Turkish Version of the Orbach Mikulincer Mental Pain Scale-8 in a Clinical Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-03-01 Mehmet Emin Demirkol, Lut Tamam, Zeynep Namlı, Caner Yeşiloğlu, Hamdi Yılmaz
Purpose: Suicide is a growing public health issue for all societies; identifying suicide risk is crucial. This study aims to evaluate the psychometric properties of the Turkish version of the Orbach and Mikulincer Mental Pain Scale-8 (OMMP-8), which enables the assessment of suicidality in a short time. Patients and Methods: We conducted this study with 148 individuals diagnosed with major depressive
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The Impact of Recent Life Events, Internalizing Symptoms, and Emotion Regulation on the Severity of Non-Suicidal Self-Injury in Adolescents: A Mediation Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-29 Linqi Zhou, Changyuan Qiao, Jialing Huang, Jian Lin, Haisheng Zhang, Jian Xie, Yonggui Yuan, Changchun Hu
Background: Previous studies have demonstrated a strong association between recent stressful life events and non-suicidal self-injury (NSSI) among adolescents. Internalizing symptoms and difficulty in emotion regulation (DER) may mediate this relationship. This study aimed to investigate the relationship between recent stressful life events and NSSI severity in adolescents and the potential moderating
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Gut Microbiota Dysbiosis and Inflammation Dysfunction in Late-Life Depression: An Observational Cross-Sectional Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-27 Yan Chen, Dansheng Le, Jiaxi Xu, Piaopiao Jin, Yuhan Zhang, Zhengluan Liao
Purpose: There are some challenges to diagnosis in the context of similar diagnostic criteria for late-life depression (LLD) and adult depression due to cognitive impairment and other clinical manifestations. The association between gut microbiota and inflammation remains unclear in LLD. We analyzed gut microbiota characteristics and serum inflammatory cytokines in individuals with LLD to explore the
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Vitamin D Deficiency Participates in Depression of Patients with Diabetic Peripheral Neuropathy by Regulating the Expression of Pro-Inflammatory Cytokines Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-27 Jingjing Zhou, Dongfeng Li, Youmin Wang
Objective: Vitamin D deficiency is associated with patients with diabetic peripheral neuropathy (DPN), and low levels of vitamin D are common in patients with depression. Depression is common in DPN patients and the definite pathogenesis remains unclear. This study aimed to determine vitamin D deficiency in the onset of depression in DPN and evaluate the effect of vitamin D supplementation on depression
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Hormonal Changes in Women with Epilepsy Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-26 Qiwei Li, Zhiyun Zhang, Jiajia Fang
Abstract: Epilepsy is a prevalent neurological disorder among women globally, often requiring long-term treatment. Hormonal fluctuations in women with epilepsy (WWE) can have reciprocal effects on epilepsy and antiseizure medications (ASMs), posing significant challenges for WWE. Notably, WWE commonly experience endocrine alterations such as thyroid dysfunctions, low bone metabolism, and reproductive
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Comparative Analysis of Personality Traits in Major Depressive Disorder and Bipolar Disorder: Impact, Differences, and Associations with Symptoms Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-23 Tian Li, Ruinan Li, Lei Zhao, Yue Sun, Chuanyue Wang, Qijing Bo
Purpose: This cross-sectional study aimed to compare the personality traits of patients with major depressive disorder (MDD) and bipolar disorder (BD) with those of healthy individuals. The goal was to gain insight into the potential impact of personality traits on the development and manifestation of mood disorders. Methods: One hundred seventy-eight patients with mood disorders were analyzed as either
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Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-23 Qingyan Jiao, Yeqing Dong, Xiaojuan Ma, Shiyi Suzy Ji, Xinyu Liu, Jian Zhang, Xia Sun, Dazhi Li, Xingguang Luo, Yong Zhang
Purpose: Major depressive disorder (MDD) is associated with worse cognitive functioning. We aim to examine the association between baseline cognitive functioning and the reduction rate in HDRS-17 total scores and to highlight the predictors of the reduction rate in HDRS-17 total scores in MDD with first-episode, drug-naïve (FED) patients. Patients and Methods: Ninety FED patients were recruited consecutively
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What Do Farmers Need for Suicide Prevention: Considerations for a Hard-to-Reach Population Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-22 Anna Scheyett, Ian Lee Marburger, Andrea Scarrow, Stephanie M Hollifield, Jennifer Ward Dunn
Purpose: Farmers have suicide rates much higher than the general population, with elevated mental health symptoms and high stress levels. Farmers are a hard-to-reach population due to occupational demands and a culture where conversations about mental health are often stigmatizing. This study explored ways to tailor suicide prevention strategies to unique characteristics of farmers by speaking with
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Identification and Analysis of ZIC-Related Genes in Cerebellum of Autism Spectrum Disorders Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-22 Heli Li, Jinru Cui, Cong Hu, Hao Li, Xiaoping Luo, Yan Hao
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic heterogeneity. The ZIC gene family can regulate neurodevelopment, especially in the cerebellum, and has been implicated in ASD-like behaviors in mice. We performed bioinformatic analysis to identify the ZIC gene family in the ASD cerebellum. Methods: We explored the roles of ZIC family genes
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Association of Age and Response to Methylphenidate HCL Treatment in Adult ADHD: A Proton Magnetic Resonance Spectroscopy Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Gonca Ayse Unal, Ayse Nur Inci Kenar
Purpose: This study investigated the age-dependent effects of methylphenidate (MPH) on brain metabolites including choline (Cho), N-acetyl aspartate (NAA) and creatine (Cr) levels in the dorsolateral prefrontal cortex (DLPFC), striatum, cerebellum, and anterior cingulate cortex (ACC) regions of the brain in adult patients with attention deficit hyperactivity disorder (ADHD). Patients and Methods: The
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Research Advancements on the Correlation Between Spontaneous Intracerebral Hemorrhage of Different Etiologies and Imaging Markers of Cerebral Small Vessel Disease Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Yu-Tong Liu, Chun-Yan Lei, Lian-Mei Zhong
Objective: The purpose of this review is to identify the correlation between ICH and CSVD imaging markers under SMASH-U classification by searching and analyzing a large number of literatures in recent years, laying a theoretical foundation for future clinical research. At the same time, by collecting clinical data to evaluate patient prognosis, analyzing whether there are differences or supplements
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The Association between Acupuncture Therapy and the Risk of Disability Development in Dementia Patients: A Nationwide Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-20 Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Peter Karl Mayer, Hung-Rong Yen
Purpose: Disability is the comorbidity of dementia for which there is no available preventive measure. The aim of this study was to investigate the association between acupuncture treatment and the risk of disability development in dementia patients. Patients and Methods: A cohort study was performed using a nationwide health database in Taiwan. The included dementia patients were divided into acupuncture
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Genetic Markers Associated with Postpartum Depression: A Review Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-15 Joshua Harry Chandra, Candy Kurniawan, Irma Melyani Puspitasari
Abstract: Postpartum depression (PPD) is a common illness in mothers after childbirth. PPD negatively affect the mother’s quality of life and the bond with the infant, which can interfere with the infant’s emotional, social, and cognitive development. PPD is caused by various biological and psychosocial factors. The aim of this review is to summarize the latest evidence of the associations between
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Lifestyle Influence on Mild Cognitive Impairment Progression: A Decision Tree Prediction Model Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-12 Jiwen Hou, Hua Jiang, Yan Han, Rong Huang, Xiang Gao, Wei Feng, Zongjun Guo
Purpose: This study assessed the influences of different lifestyle on mild cognitive impairment (MCI) progression and established a decision tree prediction model to analyse their predictive significance on MCI progression incidence. Patients and Methods: From October 2015 to February 2020,330 patients with MCI were recruited, and demographic and lifestyle information collected. They were followed
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Perspectives from Adults with Tourette Syndrome on Research Priorities and Registry Development: A Focus Group Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-09 David A Isaacs, Kemberlee Bonnet, Michelle R Eckland, Kimberly Markowitz, Maria Pena, David G Schlundt
Purpose: Adults with Tourette syndrome (TS) have worse mental health, physical health, and quality of life than the general population. The factors contributing to negative outcomes across multiple health domains in adults with TS remain uncertain, in part due to a lack of longitudinal studies in this population. In attempt to address these knowledge gaps, our center has initiated development of a
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Excess Mortality in Individuals with Autism Spectrum Disorder: A Population-Based Cohort Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-08 Yu-Hsin Huang, Shu-I Wu, Min-Jing Lee, Yi-Lung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tai-Hsin Hung, Michael E Dewey, Robert Stewart, Vincent Chin-Hung Chen
Purpose: Autism spectrum disorder (ASD) may be associated with increased mortality, but relevant findings have been inconsistent. The modifying effects of gender and intellectual disability on excess mortality in individuals with ASD are underexplored. Patients and Methods: Using Taiwan’s National Health Insurance Research Database and the National Death Registry, this population-based cohort study
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A Thematic Analysis Investigating the Inaugural Psychosis REACH Family Ambassador Peer Training Program Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-08 Akansha Vaswani-Bye, Chris McCain, Jennifer M Blank, Mackenzie E Tennison, Sarah L Kopelovich
Purpose: Caregivers of loved ones with psychosis are tasked with navigating a barren care landscape for their loved ones and for themselves. The dearth of resources they face has a negative impact on outcomes for caregivers and their loved ones. The Psychosis REACH program, based on principles from Cognitive Behavioral Therapy for psychosis was developed as a community-based resource for families to
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Characteristics of Oral-Gut Microbiota in Model Rats with CUMS-Induced Depression Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-05 Yan Li, Penghong Liu
Purpose: The diversity and composition of the oral and gut microbiota of depressed rats were analyzed to explore the microbiological etiology of major depressive disorder (MDD). Methods: The depressed rat model was established by inducing chronic unpredictable mild stress (CUMS). After the establishment of the model, body weight measurements and behavioral tests were conducted. The diversity and composition
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18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-03 Feng Wang, Shu-Ting Hong, Ying Zhang, Zhen Xing, Yuan-Xiang Lin
Purpose: To determine the diagnostic and localization value of 18F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery. Methods: One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic
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The Inter-Relationships Between Depressive Symptoms and Suicidality Among Macau Residents After the “Relatively Static Management” COVID-19 Strategy: A Perspective of Network Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-02-03 Mei Ieng Lam, Hong Cai, Pan Chen, Ka-In Lok, Ines Hang Iao Chow, Tong Leong Si, Zhaohui Su, Chee H Ng, Feng-Rong An, Yu-Tao Xiang
Background: Suicidality is a global public health problem which has increased considerably during the coronavirus disease 2019 (COVID-19) pandemic. This study examined the inter-relationships between depressive symptoms and suicidality using network analysis among Macau residents after the “relatively static management” COVID-19 strategy. Methods: An assessment of suicidal ideation (SI), suicide plan
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Association of HTR1A Gene Polymorphisms with Efficacy and Plasma Concentrations of Atypical Antipsychotics in the Treatment of Male Patients with Schizophrenia Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-30 Ying Qin, Jingwen Zhao, Yong Yang, Yanjing Liu, Hui Xiang, Jingfeng Tong, Chengchen Huang
Purpose: We investigate the association of HTR1A rs10042486 and rs6295 with efficacy and plasma concentrations of atypical antipsychotics in the treatment of male patients with schizophrenia. Patients and Methods: A total of 140 male patients diagnosed with schizophrenia who were treated with any single atypical antipsychotic between May 2020 and May 2022 were retrospectively included. Clinical symptoms
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Effect of Object on Kinesthetic Motor Imagery in Autism Spectrum Disorder: A Pilot Study Based on Eye-Tracking Methodology Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-24 Ying Liu, Jinsheng Hu
Introduction: Social disturbance is a significant autism spectrum disorder (ASD) symptom. Action representation, which is a fundamental component of social interaction, can be investigated through kinesthetic motor imagery (KMI). KMI has been commonly studied with the well-developed laterality judgment paradigm, wherein participants are required to discriminate the laterality of a hand rotated by different
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Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-24 Ayse Dondu, Metin Caliskan, Seda Orenay-Boyacioglu
Objective: Many researchers have considered obsessive compulsive disorder (OCD) to be a neurodegenerative disease just like Alzheimer’s disease (AD). The most studied gene in neurodegenerative diseases is apolipoprotein E (ApoE) gene, and ApoE ɛ4 allele in particular. Although a small number of studies have explored the relationship between ApoE gene polymorphisms and OCD, the link between age at onset
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Decline in Working Memory in Stable Schizophrenia May Be Related to Attentional Impairment: Mediating Effects of Negative Symptoms, a Cross-Sectional Study Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-23 Nan Du, Xiaojing Meng, Jingwei Li, Li Shi, Xulai Zhang
Background: Schizophrenia (SCZ) is a severe mental illness, Cognitive deficits and negative symptoms (NS) are prevalent in individuals with SCZ and are crucial indicators of functional recovery. It is well known that cognitive symptoms and negative symptoms are interrelated and that negative symptoms can affect the ability to take cognitive tests. However, the specific relationship between attention
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Mind Matters: Exploring the Intersection of Psychological Factors and Cognitive Abilities of University Students by Using ANN Model Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-22 Mohsin Khan, Syed Khalid Perwez, Rahul Paul Gaddam, Rabuni Aiswarya, Mohammed Abrar Basha, Abhradeep Malas, Shafiul Haque, Faraz Ahmad
Purpose: While previous studies have suggested close association of psychological variables of students withtheir higher-order cognitive abilities, such studies have largely been lacking for third world countries like India, with their unique socio-economic-cultural set of challenges. We aimed to investigate the relationship between psychological variables (depression, anxiety and stress) and cognitive
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Trauma-Informed Care in Psychedelic Therapy Research: A Qualitative Literature Review of Evidence-Based Psychotherapy Interventions in PTSD and Psychedelic Therapy Across Conditions Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-20 Nadav Liam Modlin, Michael Creed, Maria Sarang, Carolina Maggio, James J Rucker, Victoria Williamson
Introduction: Post-traumatic stress disorder (PTSD) is associated with significant patient burden. While pharmacotherapies and evidence-based psychotherapy interventions (EBPI) are effective, studies consistently highlight inadequate outcomes and high treatment dropout. Psychedelic therapy (PT) has shown preliminary promise across difficult-to-treat conditions, including MDMA-assisted therapy for PTSD
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Relationship Between Liver Fibrosis and Increased Risk of Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients Undergoing Mechanical Thrombectomy Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-18 Jing Xu, Xiaohao Zhang, Yan E, Wei Wang, Junshan Zhou, Yanyan Shi, Shuaiyu Chen
Background: Liver fibrosis has been reported to be associated with hematoma expansion and mortality in patients with intracerebral hemorrhage. This study aimed to detect the association between liver fibrosis and symptomatic intracranial hemorrhage (sICH) in ischemic stroke after mechanical thrombectomy (MT). Methods: We retrospectively included patients with large artery occlusion in the anterior
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Knockdown of LCN2 Attenuates Brain Injury After Intracerebral Hemorrhage via Suppressing Pyroptosis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-17 Yangyang Zhao, Qiuxiang Xiao, Tao Sun, Haiyun Yu, Muyun Luo
Objective: The aims of this study are to screen novel differentially expressed genes (DEGs) for intracerebral hemorrhage (ICH) and reveal the role of Lipocalin-2 (LCN2) in ICH. Methods: We constructed the ICH model by injection of autologous whole blood into the right basal ganglia in rats. RNA-sequencing and bioinformatics analyses were performed to identify the DEGs between ICH and sham rats, and
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A Cross-Sectional Survey on Psychological Health and Influencing Factors Among 2628 Asymptomatic and Mild COVID-19 Patients in Fangcang Shelter Hospital Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-16 Min Zhao, Fei-xiang Liu, Xiao-lin Wang, Ya-hui Gao, Xiang Li
Purpose: The Coronavirus disease 2019 (COVID-19) remains a global public health concern. Many people have been forced to change their lifestyles, which has led to psychological and sleep problem. This study aims to investigate the psychological health problems and factors among patients in the Fangcang Shelter Hospital (FSH) during the COVID-19 pandemic. Patients and Methods: A Cross-Sectional survey
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Clinical Features of Patients with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease and Isolated Seizure Symptoms Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-16 Yun Yang, Chao Zhang, Chen Cao, Wenhua Su, Na Zhao, Wei Yue
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody–associated encephalitis is a new clinical phenotype of inflammatory demyelinating diseases. Some MOG antibody–positive patients with central nervous system demyelinating events present with isolated seizures. However, there are gaps in the epidemiological knowledge regarding seizures with MOG antibody–associated encephalitis in adults.
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Goal Attainment Scaling for Depression: Validation of the Japanese GAS-D Tool in Patients with Major Depressive Disorder Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-16 Masaki Kato, Toshiaki Kikuchi, Koichiro Watanabe, Tomiki Sumiyoshi, Yoshiya Moriguchi, Daniel Oudin Åström, Michael Cronquist Christensen
Purpose: Goal attainment scaling (GAS) has been proposed as a person-centric, semi-quantitative measure that assimilates achievement of individually set goals into a single standardized “goal attainment score” that can be compared at the population level. We aimed to examine the reliability and validity of the Japanese version of the GAS for depression (GAS-D) tool in assessing goal attainment in people
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Predicting Communication Skills Outcomes for Preschool Children with Autism Spectrum Disorder Following Early Intervention Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-08 Nadine Kauley, James Rufus John, Karlen R Barr, Weng Tong Wu, Rachel Grove, Anne Masi, Valsamma Eapen
Purpose: This study aims to assess changes in the receptive and expressive language skills and to determine if the baseline characteristics such as communication, cognitive and motor skills, predict outcomes in preschool children with Autism Spectrum Disorder (ASD) following early intervention. Methods: We recruited 64 children participating in the Early Start Denver Model (ESDM) early intervention
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Cognitive Profiles Stratified by Education Using Montreal Cognitive Assessment in Parkinson’s Disease Patients with Freezing of Gait Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-08 Fangju Lin, Weihua Jia, Xuemei Li, Ying Chen, Min Wan
Purpose: Parkinson’s disease (PD) patients with freezing of gait (FOG) may present with complex and heterogeneous cognitive profiles. Owing to limited access to comprehensive neuropsychological battery in ordinary clinical practice, the Montreal Cognitive Assessment (MoCA) is likely to be easily available cognitive data for comparisons among studies. This study aims to explore the cognitive profiles
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Biological Markers in Newly Diagnosed Generalized Anxiety Disorder Patients: 8-OHdG, S100B and Oxidative Stress Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-06 Meltem Oktay, Mehmet Asoğlu, Seyhan Taskin, Adnan Kirmit
Purpose: Generalized Anxiety Disorder (GAD) is a chronic disease persisting for at least 6 months, characterized by excessive and continuous anxiety, which leads to evident problems and functional disorders. S100B is a glial protein that plays a role in intercellular communication regulating cell growth and differentiation, and intracellular signal transmission. This study aimed to analyze the serum
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Understanding Comorbidity Between Non-Suicidal Self-Injury and Depressive Symptoms in a Clinical Sample of Adolescents: A Network Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2024-01-04 Shan Niu, Xiaoxiao Yin, Bing Pan, Haotian Chen, Chunxiao Dai, Chunnan Tong, Fang Chen, Xiuqin Feng
Background: Non-suicidal self-injury (NSSI) and depression often co-occur among adolescents with more severe clinical symptoms. This study examined the network structures of NSSI and depressive symptoms in adolescents. Methods: Participants were recruited in the psychiatric outpatient clinics of three tertiary hospitals between April 10 and July 10, 2023. All participants been already found with self-injury
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A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-27 Lien Wang, Xiaowei Chen, Xiaojing Gu, Heidi De Smedt, Vanina Popova, Dong-Jing Fu, Carla M Canuso, Wayne C Drevets, Guang Chen
Purpose: This meta-analysis assessed whether atypical antipsychotics (AAPs) and esketamine nasal spray (ESK-NS), which are mechanistically distinct, differ in antidepressant outcomes. Patients and Methods: Data were extracted from 12 trials of ESK-NS or AAPs in depressed patients (4276) with inadequate response or resistance to conventional antidepressants. Montgomery-Åsberg Depression Rating Scale
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Risk Factors Associated with Epilepsy Related to Cerebrovascular Disease: A Systematic Review and Meta-Analysis Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-27 Ana Paula Mafla-Mendoza, Esteban David Paredes-Urbano, Enrique Gea-Izquierdo
Background and Objective: Stroke is one of the most frequent neurological syndromes in the adult population and the cause of 10% of all diagnosed epilepsies. It is attributed to the origin of up to 50% of them in adults > 60 years of age. Although a few risk factors have been described and considered when modeling predictive tools, this aspect is still clinically complex. The objective of this study
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Examining the Role of GLU/GABA to GLN Metabolic Cycle in the Pathogenesis of Post-Stroke Depressive Disorder and Insomnia Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-22 Xiao-Hua Zhang, Xin Zhang, Xuan-Wei Liu, Peng-Hui Lai, Chang-Chun Cao, Yu-Long Wang, Li-Jie Ren
Objective: This study aims to elucidate the potential links between the GLU/GABA to GLN metabolic cycle disruptions and the onset of depressive and insomnia disorders following a stroke. We particularly focus on understanding if these disorders share a common underlying pathogenic mechanism. Methods: We examined 63 patients with post-stroke insomnia, 62 patients with post-stroke depression, and 18
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Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-21 Andrea Fagiolini, Ana González Pinto, Kamilla Woznica Miskowiak, Pedro Morgado, Allan H Young, Eduard Vieta
Objective: Major depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses
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The Interaction of LAMA2 and Duration of Illness Affects the Thickness of the Right Transverse Temporal Gyrus in Major Depressive Disorder Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-20 Gang Chen, Lei Li, Taipeng Sun, Chenguang Jiang, Wei Xu, Suzhen Chen, Changchun Hu, Yingying Yue, Tianyu Wang, Wenhao Jiang, Yonggui Yuan
Background: Depression is a heritable brain disorder. Laminin genes were recently identified to affect the brain’s overall thickness through neurogenesis, differentiation, and migration in depression. This study aims to explore the effects of the LAMA2’s single nucleotide polymorphisms (SNP), a subunit gene of laminin, on the detected brain regions of patients with major depressive disorder (MDD).
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Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-14 Haonan Zhang, Jun Chen, Yiru Fang
Abstract: Bipolar disorder (BD) profoundly affects cognitive and psychosocial functioning, leading to a significant illness burden on patients and their families. Genetic factors are predominant in the onset of bipolar disorder and functional impairments. This disorder exhibits a strong family aggregation, with heritability estimates reaching up to 80%. Individuals with BD often experience impaired
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A Linear Regression Equation for Predicting the Residual Volume of Chronic Subdural Hematoma 1 Week After Surgery Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-14 Chao Yan, Chang Su, Yu-fei Ye, Jin Liu
Objective: The outcome of chronic subdural hematoma (CSDH) is influenced not only by the choice of treatment but also by various baseline characteristics. The main objective of this study is to identify the risk factors that can affect the prognosis of CSDH and develop a regression equation based on these risk factors. Methods: A total of 212 patients with CSDH were included in the study. We collected
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Regional Homogeneity of the Left Posterior Cingulate Gyrus May Be a Potential Imaging Biomarker of Manic Episodes in First-Episode, Drug-Naive Bipolar Disorder Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-12 Jiajia Wu, Shuangyu Qi, Wei Yu, Yujun Gao, Jun Ma
Introduction: Abnormal brain networks with emotional response in bipolar disorder (BD). However, there have been few studies on the local consistency between manic episodes in drug-naive first-episode BD patients and healthy controls (HCs). The purpose of this study is to evaluate the utility of neural activity values analyzed by Regional Homogeneity (ReHo). Methods: Thirty-seven manic episodes in
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Prediction of Acute Kidney Injury in Intracerebral Hemorrhage Patients Using Machine Learning Neuropsychiatr. Dis. Treat. (IF 3.2) Pub Date : 2023-12-11 Suhua She, Yulong Shen, Kun Luo, Xiaohai Zhang, Changjun Luo
Background: Acute kidney injury (AKI) is prevalent in patients with intracerebral hemorrhage (ICH) and is associated with mortality. This study aimed to verify the predictive accuracy of different machine learning algorithms for AKI in patients with ICH using a large dataset. Methods: A total of 1366 ICH patients received treatments between 2001 and 2012 from the Medical Information Mart for Intensive