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Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study) Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-03-11 Tatsuo Akechi, Toshiaki A. Furukawa, Hisashi Noma, Hiroji Iwata, Tatsuya Toyama, Kenji Higaki, Hiromichi Matsuoka, Sadamoto Zenda, Tsuguo Iwatani, Kazuhisa Akahane, Akira Inoue, Yasuaki Sagara, Megumi Uchida, Fuminobu Imai, Kanae Momino, Gen Imaizumi, Takuhiro Yamaguchi, Tomoe Mashiko, Tempei Miyaji, Masaru Horikoshi, Naomi Sakurai, Tatsuya Onishi, Yukihide Kanemitsu, Takeshi Murata, Yumi Wanifuchi-Endo
Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone
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The American Journal of Psychiatry: Table of Contents Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-03-12
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Potential Role of Anti‐Inflammatory Cytokines in Postpartum Depression: Considerations for Future Research and Improvement Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-03-12 Vanessa Veltre, Lothar Vidal, David F. Lo
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Corticostriatal causality analysis in children and adolescents with attention‐deficit/hyperactivity disorder Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-03-06 Fanyu Zhang, Yilu Li, Lin Liu, Yefen Liu, Pan Wang, Bharat B. Biswal
AimThe effective connectivity between the striatum and cerebral cortex has not been fully investigated in attention‐deficit/hyperactivity disorder (ADHD). Our objective was to explore the interaction effects between diagnosis and age on disrupted corticostriatal effective connectivity and to represent the modulation function of altered connectivity pathways in children and adolescents with ADHD.MethodsWe
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Unexpected risk factors of pathological hikikomori during the COVID-19 pandemic among working adults initially without social isolation: A longitudinal online survey Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-28 Kuan-Lun Huang, Ryoko Katsuki, Taisei Kubo, Jiun-Yi Wang, Shinji Sakamoto, Tomohiro Nakao, Takahiro A. Kato
Hikikomori, characterized by 6 months of home confinement and social avoidance,1 is now listed in the DSM-5-TR.2 Previous studies linked hikikomori to various factors including stressful events, social anxiety, depression,3 modern-type depression (MTD),4 amotivation,5 internet addiction and gaming disorder.6 After the COVID-19 pandemic, physical isolation isn't always pathological, necessitating crucial
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Unraveling the gut‐brain connection: The association of microbiota‐linked structural brain biomarkers with behavior and mental health Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-29 Oren Contreras‐Rodriguez, Gerard Blasco, Carles Biarnés, Josep Puig, Maria Arnoriaga‐Rodríguez, Clàudia Coll‐Martinez, Jordi Gich, Lluís Ramió‐Torrentà, Anna Motger‐Albertí, Vicente Pérez‐Brocal, Andrés Moya, Joaquim Radua, José Manuel‐Fernández‐Real
AimThe gut microbiota can influence human behavior. However, due to the massive multiple‐testing problem, research into the relationship between microbiome ecosystems and the human brain faces drawbacks. This problem arises when attempting to correlate thousands of gut bacteria with thousands of brain voxels.MethodsWe performed brain magnetic resonance imaging (MRI) scans on 133 participants and applied
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Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-28 Jun Miyata, Akihiko Sasamoto, Takahiro Ezaki, Masanori Isobe, Takanori Kochiyama, Naoki Masuda, Yasuo Mori, Yuki Sakai, Nobukatsu Sawamoto, Shisei Tei, Shiho Ubukata, Toshihiko Aso, Toshiya Murai, Hidehiko Takahashi
AimWhile conservatism bias refers to the human need for more evidence for decision‐making than rational thinking expects, the jumping to conclusions (JTC) bias refers to the need for less evidence among individuals with schizophrenia/delusion compared to healthy people. Although the hippocampus‐midbrain‐striatal aberrant salience system and the salience, default mode (DMN), and frontoparietal networks
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Brexpiprazole‐related tardive dystonia in a young patient with schizophrenia: A case report Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-26 Takumi Ebina, Kunihiro Iwamoto, Masashi Ikeda
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Comparing the performance of ChatGPT GPT‐4, Bard, and Llama‐2 in the Taiwan Psychiatric Licensing Examination and in differential diagnosis with multi‐center psychiatrists Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-26 Dian‐Jeng Li, Yu‐Chen Kao, Shih‐Jen Tsai, Ya‐Mei Bai, Ta‐Chuan Yeh, Che‐Sheng Chu, Chih‐Wei Hsu, Szu‐Wei Cheng, Tien‐Wei Hsu, Chih‐Sung Liang, Kuan‐Pin Su
AimLarge language models (LLMs) have been suggested to play a role in medical education and medical practice. However, the potential of their application in the psychiatric domain has not been well‐studied.MethodIn the first step, we compared the performance of ChatGPT GPT‐4, Bard, and Llama‐2 in the 2022 Taiwan Psychiatric Licensing Examination conducted in traditional Mandarin. In the second step
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Effects of functional polymorphisms of opioid receptor mu 1 and catechol‐O‐methyltransferase on the neural processing of pain Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-26 Yongjeon Cheong, Seonkyoung Lee, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung
AimPain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single‐nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) A118G (rs1799971) and catechol‐O‐methyltransferase (COMT) val158met (rs4680), we investigated how
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Functional brain connectivity prior to the COVID‐19 outbreak predicts mental health trajectories during two years of pandemic Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-19 María Cabello‐Toscano, Lídia Vaqué‐Alcázar, Ivet Bayes‐Marin, Gabriele Cattaneo, Javier Solana‐Sánchez, Lídia Mulet‐Pons, Nuria Bargalló, Josep M. Tormos, Alvaro Pascual‐Leone, David Bartrés‐Faz
While acknowledging the hardships caused by COVID-19, the pandemic also provided a unique opportunity to study mental well-being and individual vulnerability or resilience.1, 2 Sociodemographic, psychological factors, and lifestyles, have been identified as predictors of mental health during COVID-19.3 Our previous study demonstrated the relevance of the interplay between psychological measures and
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Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter-, cell type-specific and chromosome- transcriptomic signatures Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-09 Zhiyi Chen, Ting Xu, Xuerong Liu, Benjamin Becker, Wei Li, Lei Xia, Wenqi Zhao, Rong Zhang, Zhenzhen Huo, Bowen Hu, Yancheng Tang, Zhibing Xiao, Zhengzhi Feng, Ji Chen, Tingyong Feng
This study aimed to illuminate the neuropathological landscape of attention deficit hyperactivity disorder (ADHD) by a multiscale macro–micro-molecular perspective from in vivo neuroimaging data.
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Exploration of cell type–specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-09 Jianbin Du, Yutaka Nakachi, Yui Murata, Emi Kiyota, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto
Schizophrenia (SZ) is a severe psychiatric disorder caused by the interaction of genetic and environmental factors. Although somatic mutations that occur in the brain after fertilization may play an important role in the cause of SZ, their frequencies and patterns in the brains of patients and related animal models have not been well studied. This study aimed to find somatic mutations related to the
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Corrigendum to “One-year outcomes of deep brain stimulation in refractory Tourette syndrome” Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-09
Lee, J, Chang, KW, Jung, HH, Kim, D, Chang, JW, Song, DH. One-year outcomes of deep brain stimulation in refractory Tourette syndrome. Psychiatry Clin. Neurosci. 2023; 77: 605-612. In the ‘keywords’ section, the keyword ‘deep brain syndrome’ is incorrect. It should be: ‘deep brain stimulation’. We apologize for this error.
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Atypical brain responses to 40-Hz click trains in girls with Rett syndrome: Auditory steady-state response and sustained wave Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-02-06 Anastasia Neklyudova, Rabiat Kuramagomedova, Victoria Voinova, Olga Sysoeva
The current study aimed to infer neurophysiological mechanisms of auditory processing in children with Rett syndrome (RTT)—rare neurodevelopmental disorders caused by MECP2 mutations. We examined two brain responses elicited by 40-Hz click trains: auditory steady-state response (ASSR), which reflects fine temporal analysis of auditory input, and sustained wave (SW), which is associated with integral
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Corrigendum Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-01-22
Esaki Y, Obayashi K, Saeki K, Fujita K, Iwata N, Kitajima T. Circadian variability of objective sleep measures predicts the relapse of a mood episode in bipolar disorder: findings from the APPLE cohort. Psychiatry Clin. Neurosci. 2023; 77: 442–448. On page 445, the word ‘Replace’ in the legend of Figure 1 should have been indicated as ‘Relapse’. The correct figure is as follows: We apologize for this
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Corrigendum to “Predictors of non-adherence to public health instructions during the COVID-19 pandemic” Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-01-11
Pollak, Y, Dayan, H, Shoham, R, Berger, I. Predictors of non-adherence to public health instructions during the COVID-19 pandemic. Psychiatry Clin. Neurosci. 2020; 74: 602–604. This paper uses data based on the administration of only one of the five Strengths and Difficulties Questionnaire (SDQ) subscales. This is not permitted under the SDQ terms of use, which require users to administer authorized
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Correction to “Long-term benefits of mindfulness on white matter tracts underlying the cortical midline structures in panic disorder: A 2-year longitudinal study” Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2024-01-01
The authors would like to draw the reader's attention to an error in the following article: Bang M. Kim B, Lee KS, Choi TK, Lee S-H. Long-term benefits of mindfulness on white matter tracts underlying the cortical midline structures in panic disorder: A 2-year longitudinal study. Psychiatry Clin. Neurosci. 2023; 77: 355–364. doi: 10.1111/pcn.13544. On page 362, in the Acknowledgments, one of the grant
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Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-12-19 Lena K.L. Oestreich, Jessica W. Lo, Maria A. Di Biase, Perminder S. Sachdev, Alice H. Mok, Paul Wright, John D. Crawford, Ben Lam, Latchezar Traykov, Sebastian Köhler, Julie E.A. Staals, Robert van Oostenbrugge, Christopher Chen, David W. Desmond, Kyung-Ho Yu, Minwoo Lee, Aleksandra Klimkowicz-Mrowiec, Régis Bordet, Michael J. O'Sullivan, Andrew Zalesky
Recovery from stroke is adversely affected by neuropsychiatric complications, cognitive impairment, and functional disability. Better knowledge of their mutual relationships is required to inform effective interventions. Network theory enables the conceptualization of symptoms and impairments as dynamic and mutually interacting systems. We aimed to identify interactions of poststroke complications
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Live two-way video versus face-to-face treatment for depression, anxiety, and obsessive-compulsive disorder: A 24-week randomized controlled trial Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-12-15 Taishiro Kishimoto, Shotaro Kinoshita, Momoko Kitazawa, Akitoyo Hishimoto, Takeshi Asami, Akira Suda, Shogyoku Bun, Toshiaki Kikuchi, Mitsuhiro Sado, Akihiro Takamiya, Masaru Mimura, Yasunori Sato, Ryo Takemura, Kengo Nagashima, Takashi Nakamae, Yoshinari Abe, Tetsufumi Kanazawa, Yasuo Kawabata, Hiroaki Tomita, Koichi Abe, Seiji Hongo, Hiroshi Kimura, Aiko Sato, Hisashi Kida, Kei Sakuma, Michitaka
Live two-way video, easily accessible from home via smartphones and other devices, is becoming a new way of providing psychiatric treatment. However, lack of evidence for real-world clinical setting effectiveness hampers its approval by medical insurance in some countries. Here, we conducted the first large-scale pragmatic, randomized controlled trial to determine the effectiveness of long-term treatment
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Repetitive deep TMS in alcohol dependent patients halts progression of white matter changes in early abstinence Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-12-12 Mohamed Kotb Selim, Maayan Harel, Silvia De Santis, Irene Perini, Wolfgang H. Sommer, Markus Heilig, Abraham Zangen, Santiago Canals
Alcohol use disorder (AUD) is the most prevalent form of addiction, with a great burden on society and limited treatment options. A recent clinical trial reported significant clinical benefits of deep transcranial magnetic stimulations (Deep TMS) targeting midline frontocortical areas. However, the underlying biological substrate remained elusive. Here, we report the effect of Deep TMS on the microstructure
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Acknowledgments Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-12-07 Tadafumi Kato, Hidehiko Takahashi
This year Masashi Ikeda (Nagoya) joined Psychiatry and Clinical Neurosciences (PCN) as a Field Editor. We are extremely grateful to the editors for accepting these positions, despite their busy schedules. In the current volume of PCN, Volume 77, there have been 12 published issues, which have included eight editorials, five PCN frontier reviews, five review articles, one timely review, one bibliometric
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Single-cell RNA sequencing reveals diverse B cell phenotypes in patients with anti-NMDAR encephalitis Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-12-08 Sisi Li, Xiang Hu, Minjin Wang, Luoting Yu, Qi Zhang, Jing Xiao, Zhen Hong, Dong Zhou, Jinmei Li
Anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E) is a severe autoimmune disorder characterized by prominent psychiatric symptoms. Although the role of NMDAR antibodies in the disease has been extensively studied, the phenotype of B cell subsets is still not fully understood.
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Correction to “Liberating older adults from the bonds of vascular risk factors: What is their impact on financial capacity in amnestic mild cognitive impairment?” Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-29
Giannouli V, Tsolaki M. Liberating older adults from the bonds of vascular risk factors: What is their impact on financial capacity in amnestic mild cognitive impairment? Psychiatry Clin. Neurosci. 2022; 76: 246–250. The first author, Vaitsa Giannouli, PhD at the time of submission and publication of the above article during 2022 had an additional third affiliation: Department of Educational and Social
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Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-28 Klaas Bahnsen, Marie-Louis Wronski, Johanna Louise Keeler, Joseph A. King, Quirina Preusker, Theresa Kolb, Kerstin Weidner, Veit Roessner, Fabio Bernardoni, Stefan Ehrlich
Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield-specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations
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Unveiling the potential of machine learning in schizophrenia diagnosis: A meta-analytic study of task-based neuroimaging data Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-27 Xuan Wang, Chao Yan, Peng-yuan Yang, Zheng Xia, Xin-lu Cai, Yi Wang, Sze Chai Kwok, Raymond C.K. Chan
The emergence of machine learning (ML) techniques has opened up new avenues for identifying biomarkers associated with schizophrenia (SCZ) using task-related fMRI (t-fMRI) designs. To evaluate the effectiveness of this approach, we conducted a comprehensive meta-analysis of 31 t-fMRI studies using a bivariate model. Our findings revealed a high overall sensitivity of 0.83 and specificity of 0.82 for
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Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-20 Ioannis Liampas, Vasileios Siokas, Elli Zoupa, Constantine G. Lyketsos, Efthimios Dardiotis
Lewy body dementia (LBD) is a common neurodegenerative dementia, second only to Alzheimer disease (AD).1 Biological sex appears to modify its clinical course. Epidemiological evidence indicates that LBD is more prevalent among male individuals. The cognitive burden of the disease is greater among female patients, whereas motor and sleep-related manifestations afflict male adults with greater severity
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Safety profile of antidepressant for Japanese adults with major depressive disorder: a systematic review and network meta-analysis. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-20 Taro Kishi,Toshikazu Ikuta,Kenji Sakuma,Masakazu Hatano,Yuki Matsuda,Satoru Esumi,Nobumi Miyake,Itaru Miura,Masaki Kato,Nakao Iwata
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The trajectory of depressive symptoms over time and the presence of depressive symptoms at a single time point with the risk of dementia among US older adults: A national prospective cohort study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-20 Min Du, Min Liu, Jue Liu
This study aims to assess the association between trajectories of depressive symptoms and the risk of dementia, and to compare the predictive ability of trajectories using multiple data points with depressive symptoms at a single data point.
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Altered HCAR3 expression may underlying the blunted niacin responses of the psychiatric disorders and the risk of schizophrenia Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-20 Jie Jiang, Dandan Wang, Yan Gao, Liya Sun, Shuhui Li, Xiaowen Hu, Zhuyun Li, Juan Zhang, Feng Ji, Yusheng Tian, Lili Guan, Zhiqiang Li, Lin He, Chunling Wan
Blunted niacin response (BNR) was an endophenotype of schizophrenia, but the underlying mechanism remains unclarified. The objective of this study was to verify whether genes associated with BNR pathway constitute the genetic basis and the pathological mechanism of BNR phenotypic psychiatric patients.
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Clinical outcomes of deep brain stimulation for obsessive-compulsive disorder: Insight as a predictor of symptom changes Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-20 Nicola Acevedo, Susan Rossell, David Castle, Clare Groves, Mark Cook, Peter McNeill, James Olver, Denny Meyer, Thushara Perera, Peter Bosanac
Deep brain stimulation (DBS) is a safe and effective treatment option for people with refractory obsessive-compulsive disorder (OCD). Yet our understanding of predictors of response and prognostic factors remains rudimentary, and long-term comprehensive follow-ups are lacking. We aim to investigate the efficacy of DBS therapy for OCD patients, and predictors of clinical response.
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DISC1 protein aggregates in cerebrospinal fluid as a potential diagnostic biomarker for first-episode psychosis. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-14 Nayan Suryawanshi,Motomasa Tanaka
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Correction to “Cause-specific mortality after discharge from inpatient psychiatric care in Taiwan: A national matched cohort study” Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-14
Hsu CY, Chang SS, Large M, Chang CH, Tseng MCM. Cause-specific mortality after discharge from inpatient psychiatric care in Taiwan: A national matched cohort study. Psychiatry Clin. Neurosci. 2023; 77: 290–296. In the originally published version of the above article, on page 293 there was an error in the label of the y-axis in Fig. 1. “Mortality rates per 1100,000 person-years” was incorrect. It should
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Adjunctive brexpiprazole 1 mg and 2 mg daily for Japanese patients with major depressive disorder following inadequate response to antidepressants: a phase 2/3, randomized, double-blind (BLESS) study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-11-07 Masaki Kato, Masako Shiosakai, Kazuo Kuwahara, Katsuhiro Iba, Yuki Shimada, Mizuki Saito, Yuki Isogai, Daisuke Sekine, Kazuo Aoki, Nobuyuki Koga, Teruhiko Higuchi
Inadequate antidepressant response interrupts effective treatment of major depressive disorder (MDD). The BLESS study evaluates the dosage, efficacy, and safety of brexpiprazole adjunctive therapy in Japanese patients with inadequate antidepressant therapy (ADT) response.
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Hikikomori and gaming disorder tendency: A case-control online survey for nonworking adults Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-30 Taisei Kubo, Kazumasa Horie, Toshio Matsushima, Masaru Tateno, Toshihide Kuroki, Tomohiro Nakao, Takahiro A Kato
Hikikomori is the phenomenon of staying at home almost every day and avoiding social participation for more than 6 months.1 In the post–COVID-19 era, the lifestyle of not-going-out has been considered to be not always pathological; thus, distinguishing between nonpathological hikikomori and pathological hikikomori is crucially important. We have defined pathological hikikomori (pathological social
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Asynchronous neural maturation predicts transition to psychosis Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-30 Anton Iftimovici, Julie Bourgin, Josselin Houenou, Olivier Gay, Antoine Grigis, Julie Victor, Boris Chaumette, Marie-Odile Krebs, Edouard Duchesnay
Neuroimaging-based machine-learning predictions of psychosis onset rely on the hypothesis that structural brain anomalies may reflect the underlying pathophysiology. Yet, current predictors remain difficult to interpret in light of brain structure. Here, we combined an advanced interpretable supervised algorithm and a model of neuroanatomical age to identify the level of brain maturation of the regions
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Brain-derived extracellular vesicles: Potential diagnostic biomarkers for central nervous system diseases Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-25 Xiao Xu, Zoya Iqbal, Limei Xu, Caining Wen, Li Duan, Jiang Xia, Ningning Yang, Yuanmin Zhang, Yujie Liang
Extracellular vesicles (EVs) are membrane-enclosed nanovesicles secreted by cells into the extracellular space and contain functional biomolecules, e.g. signaling receptors, bioactive lipids, nucleic acids, and proteins, which can serve as biomarkers. Neurons and glial cells secrete EVs, contributing to various physiological and pathological aspects of brain diseases. EVs confer their role in the bidirectional
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Plasma neurofilament light chain in association to late-life depression in the general population Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-16 Isabel K. Schuurmans, Mohsen Ghanbari, Charlotte A. M. Cecil, M. Arfan Ikram, Annemarie I. Luik
Investigating what is underlying late-life depression is becoming increasingly important with the rapidly growing elderly population. Yet, the associations between plasma biomarkers of neuroaxonal damage and late-life depression remain largely unclear. Therefore, we determined cross-sectional and longitudinal associations of neurofilament light chain (NfL) with depression in middle-aged and elderly
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Psychiatrist density and risk of suicide: a multilevel case-control study based on a national sample in Taiwan Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-09 Wei-Chia Huang, Chia-Yueh Hsu, Chia-Ming Chang, Albert C. Yang, Shih-Cheng Liao, Shu-Sen Chang, Chi-Shin Wu
No previous studies, to our knowledge, have investigated the association between psychiatrist density and suicide, accounting for individual- and area-level characteristics.
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A sensory signature of unaffected biological parents predicts the risk of autism in their offspring Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-08 Chenyi Chen, Yawei Cheng, Chien-Te Wu, Chung-Hsin Chiang, Ching-Ching Wong, Chih-Mao Huang, Róger Marcelo Martínez, Ovid J. L. Tzeng, Yang-Teng Fan
Despite the emphasis on sensory dysfunction phenotypes in the revised diagnostic criteria for autism spectrum disorder (ASD), there has been limited research, particularly in the field of neurobiology, investigating the concordance in sensory features between individuals with ASD and their genetic relatives. Therefore, our objective was to examine whether neurobehavioral sensory patterns could serve
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Cognitive functions and mental health of eight cases of mother-to-child HIV transmission. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-05 Toshiharu Iida,Mizue Tanaka,Yohei Kawasaki,Shinichi Oka,Hiroyuki Shichino
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Association of psychological distress and DNA methylation: A 5-year longitudinal population-based twin study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-04 Xuanming Hong, Ke Miao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
To identify the psychological distress (PD)–associated 5′-cytosine-phosphate-guanine-3′ sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD.
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Resting-state cerebral blood flow and functional connectivity abnormalities in depressed patients with childhood maltreatment: Potential biomarkers of vulnerability? Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-10-02 Sangni Liu, Dandan Fan, Cancan He, Xinyi Liu, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xie
Childhood maltreatment (CM) is an important risk factor for major depressive disorder (MDD). This study aimed to explore the specific effect of CM on cerebral blood flow (CBF) and brain functional connectivity (FC) in MDD patients.
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Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-26 Lorenzo Moccia, Michelangelo di Luzio, Eliana Conte, Marco Modica, Marianna Ambrosecchia, Martina Ardizzi, Pierluigi Lanzotti, Georgios D. Kotzalidis, Delfina Janiri, Marco Di Nicola, Luigi Janiri, Vittorio Gallese, Gabriele Sani
Sense of agency (SoA) indicates a person's ability to perceive her/his own motor acts as actually being her/his and, through them, to exert control over the course of external events. Disruptions in SoA may profoundly affect the individual's functioning, as observed in several neuropsychiatric disorders. This is the first article to systematically review studies that investigated intentional binding
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Generalist medical artificial intelligence: Embracing the future with flexible interactions. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-22 Huajie Di,Yi Wen
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Increased proportions of circulating pro-inflammatory monocytes and macrophages expressing toll-like receptor 4 in individuals with schizophrenia and bipolar disorder receiving medication. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-14 Shang-Ying Tsai,Martha Sajatovic,Pao-Huan Chen,Yu-Jui Huang,Kuo-Hsuan Chung
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Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-14 Shusei Arafuka, Hiroshige Fujishiro, Youta Torii, Hirotaka Sekiguchi, Chikako Habuchi, Ayako Miwa, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda, Norio Ozaki
Clinical studies reported that patients with schizophrenia are at a higher risk of developing dementia than people without schizophrenia. However, early neuropathological studies have shown that the incidence of Alzheimer's disease (AD) in schizophrenia patients does not differ from that in controls. These inconsistent results may be attributable to the inclusion of non-AD dementia, but there have
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Effect of education regarding treatment guidelines for schizophrenia and depression on the treatment behavior of psychiatrists: A multicenter study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-08 Naomi Hasegawa, Yuka Yasuda, Norio Yasui-Furukori, Hisashi Yamada, Hikaru Hori, Kayo Ichihashi, Yoshikazu Takaesu, Hitoshi Iida, Hiroyuki Muraoka, Fumitoshi Kodaka, Jun-ichi Iga, Naoki Hashimoto, Kazuyoshi Ogasawara, Kazutaka Ohi, Kentaro Fukumoto, Shusuke Numata, Takashi Tsuboi, Masahide Usami, Akitoyo Hishimoto, Ryuji Furihata, Taishiro Kishimoto, Toshinori Nakamura, Eiichi Katsumoto, Shinichiro
This study aims to examine the real-world effectiveness of education regarding clinical guidelines for psychiatric disorders using ‘the Effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE)’ project.
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Retraction Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-08
Retraction: [Noda Y, Sato A, Fujii K, Nagano Y, Iwasa M, Hirahata K, Kitahata R, Osawa R, A pilot study of the effect of transcranial magnetic stimulation treatment on cognitive dysfunction associated with post COVID-19 condition, Psychiatry Clin. Neurosci. 2023; 77: 241–242 (https://onlinelibrary.wiley.com/doi/10.1111/pcn.13527)].
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Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment-resistant depression following electroconvulsive therapy Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-07 Shu-xian Xu, Xin-hui Xie, Lihua Yao, Wei Wang, Honghan Zhang, Mian-mian Chen, Siqi Sun, Zhao-wen Nie, Corina Nagy, Zhongchun Liu
The current study aimed to investigate the neuroinflammatory hypothesis of depression and the potential anti-inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing astrocyte-derived extracellular vesicles (ADEVs) isolated from plasma.
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Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-09-05 Marlene Pils, Julia Rutsch, Feride Eren, Göran Engberg, Fredrik Piehl, Simon Cervenka, Carl Sellgren, Svenja Troßbach, Dieter Willbold, Sophie Erhardt, Oliver Bannach, Carsten Korth
The disrupted-in-schizophrenia 1 (DISC1) protein is a key regulator at the intersection of major signaling pathways relevant for adaptive behavior. It is prone to posttranslational changes such as misassembly and aggregation but the significance of such transformations for human mental illness has remained unclear. We aimed to demonstrate the occurrence of DISC1 protein aggregates in patients with
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Microbiome analysis of circulating bacterial extracellular vesicles in obsessive-compulsive disorder Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-30 Jee In Kang, Jun Ho Seo, Chun Il Park, Shin Tae Kim, Yoon-Keun Kim, Jung-Kyu Jang, Cheol-O Kwon, Sumoa Jeon, Hae Won Kim, Se Joo Kim
The present study examined the microbiome abundance and composition of drug-naive or drug-free patients with obsessive-compulsive disorder (OCD) compared with healthy controls. In addition, in the OCD group, the microbiome composition was compared between early-onset and late-onset OCD.
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Placebo effects on all-cause mortality of patients with COVID-19 in randomized controlled trials of interleukin 6 antagonists: A systematic review and network meta-analysis Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-30 Ping-Tao Tseng, Bing-Syuan Zeng, Trevor Thompson, Brendon Stubbs, Po-Ren Hsueh, Kuan-Pin Su, Yen-Wen Chen, Tien-Yu Chen, Yi-Cheng Wu, Pao-Yen Lin, Andre F. Carvalho, Chih-Wei Hsu, Dian-Jeng Li, Ta-Chuan Yeh, Cheuk-Kwan Sun, Yu-Shian Cheng, Yow-Ling Shiue, Chih-Sung Liang, Yu-Kang Tu
Many randomized controlled trials (RCTs) have investigated the use of interleukin 6 antagonists for the treatment of coronavirus disease 2019 (COVID-19), yielding inconsistent results. This network meta-analysis (NMA) aimed to identify the source of these inconsistent results by reassessing whether participants treated with standard of care (SoC) plus placebo have different all-cause mortality from
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Trajectories of antepartum depressive symptoms and birthweight: a multicenter and prospective cohort study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-26 Jichun Yang, Yimin Qu, Yongle Zhan, Haihui Ma, Xiaoxiu Li, Dongmei Man, Hongguo Wu, Ping Huang, Liangkun Ma, Yu Jiang
Antepartum depression is a prevalent unhealthy mental health problem worldwide, particularly in low-income countries. It is a major contributor to adverse birth outcomes. Previous studies linking antepartum depression to birthweight have yielded conflicting results, which may be the reason that the depressive symptoms were only measured once during pregnancy. This study aimed to explore the associations
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Amygdala-related electroencephalogram neurofeedback as add-on therapy for treatment-resistant childhood sexual abuse posttraumatic stress disorder: feasibility study Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-24 Naomi B. Fine, Liat Helpman, Daphna Bardin Armon, Guy Gurevitch, Gal Sheppes, Zivya Seligman, Talma Hendler, Miki Bloch
Childhood sexual abuse (CSA) among women is an alarmingly prevalent traumatic experience that often leads to debilitating and treatment-refractory posttraumatic stress disorder (PTSD), raising the need for novel adjunctive therapies. Neuroimaging investigations systematically report that amygdala hyperactivity is the most consistent and reliable neural abnormality in PTSD and following childhood abuse
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The now and future of ChatGPT and GPT in psychiatry Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-23 Szu-Wei Cheng, Chung-Wen Chang, Wan-Jung Chang, Hao-Wei Wang, Chih-Sung Liang, Taishiro Kishimoto, Jane Pei-Chen Chang, John S. Kuo, Kuan-Pin Su
ChatGPT has sparked extensive discussions within the healthcare community since its November 2022 release. However, potential applications in the field of psychiatry have received limited attention. Deep learning has proven beneficial to psychiatry, and GPT is a powerful deep learning-based language model with immense potential for this field. Despite the convenience of ChatGPT, this advanced chatbot
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Broad impact of adverse childhood experiences on postpartum maternal mental health, child-rearing behaviors, and child development in Japan. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-21 Chong Chen,Ryo Okubo,Sumiyo Okawa,Kosuke Hagiwara,Tomohiro Mizumoto,Naoko Higuchi,Shin Nakagawa,Takahiro Tabuchi
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Amantadine-induced hypersexuality in a non-Parkinsonian patient with catatonia: a case report. Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-18 Matthieu Gasnier,Ariel Frajerman,Nourredine Haddadi,Hugo Herrero,Théo Faulet,Severine Martin,Julia Korngold,Romain Colle,Emmanuelle Corruble,Walid Choucha
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Brain-derived subgroups of bipolar II depression associate with inflammation and choroid plexus morphology Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-16 Yuan Cao, Paulo Lizano, Gaoju Deng, Huan Sun, Xiaoqin Zhou, Hongsheng Xie, Yaru Zhan, Jingshi Mu, Xipeng Long, Hongqi Xiao, Shiyu Liu, Qiyong Gong, Changjian Qiu, Zhiyun Jia
Elevated inflammation and larger choroid plexus (ChP) volume has been previously identified in mood disorders. Connections between inflammation, ChP, and clinical symptoms in bipolar II depression (BDII-D) are unclear. Data-driven clustering based on neuroanatomical phenotypes may help to elucidate neurobiological associations in BDII-D.
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Association between the COVID-19 pandemic and psychiatric symptoms in people with preexisting obsessive-compulsive, eating, anxiety, and mood disorders: a systematic review and meta-analysis of before-after studies Psychiat. Clin. Neuros. (IF 11.9) Pub Date : 2023-08-11 Emma A van Reekum, Julia J Woo, Jo-Anne Petropoulos, Zainab Samaan, Lawrence Mbuagbaw
To determine whether the coronavirus disease 2019 (COVID-19) pandemic was associated with a change in psychiatric symptoms in people with preexisting obsessive-compulsive, eating, anxiety, and mood disorders compared to their prepandemic levels.