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Prevalence of prolonged grief disorder and its symptoms among bereaved individuals in China: a systematic review and meta-analysis Gen. Psychiatry (IF 11.9) Pub Date : 2024-03-01 Meng-Di Yuan, Jun-Fa Liu, Bao-Liang Zhong
Background The prevalence of prolonged grief disorder (PGD) and its symptoms among the bereaved population in China vary considerably. Aims This meta-analysis aims to estimate the prevalence of PGD and its symptoms among bereaved individuals in China. Methods We conducted a literature search in major Chinese and English databases from their inception to 4 October 2023, for cross-sectional studies on
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Debt, sleep deprivation and psychological distress among online ride-hailing drivers: evidence from China Gen. Psychiatry (IF 11.9) Pub Date : 2024-03-01 Wanjie Tang, Jingyue Chen, Simiao Wang, Xianglan Jiang, Yi Lu, Siqi Wu, Luyu Yang, Meng Tian, Han Zhang, Yinan Zhang, Jiuping Xu, Zeyuan Sun
To the editor: An online ride-hailing driver (ORHD) refers to a driver who takes orders and provides rental car services to passengers via an online service platform.1 ORHD plays a significant role in the urban transport system worldwide, operating through many platforms. According to official data from the Chinese Ministry of Transport, a total of 1.6 million vehicle transport permits were issued
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Chinese version of the Perth Alexithymia Questionnaire: psychometric properties and clinical applications Gen. Psychiatry (IF 11.9) Pub Date : 2024-03-01 Xin-Lu Cai, Qingying Ye, Ke Ni, Lin Zhu, Qian Zhang, Minmin Yin, Zhe Zhang, Wei Wei, David A. Preece, Bao-Ming Li
Background The alexithymia trait is of high clinical interest. The Perth Alexithymia Questionnaire (PAQ) was recently developed to enable detailed facet-level and valence-specific assessments of alexithymia. Aims In this paper, we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical applications. Methods In Study 1, the PAQ was administered to 990 Chinese
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Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder Gen. Psychiatry (IF 11.9) Pub Date : 2024-03-01 Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang
Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown. Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain
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Methodological considerations of priming repetitive transcranial magnetic stimulation protocols in clinical populations Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Jack Jiaqi Zhang, Zhongfei Bai, Kenneth N K Fong
To the editor: Repetitive transcranial magnetic stimulation (rTMS) is a neuroplasticity-enhancing technique that modifies brain responsiveness to various therapeutic modalities in clinical psychiatric and neurological applications.1 Furthermore, its effect can be attributed to long-term potentiation (LTP) or long-term depression (LTD)-like neuroplasticity. However, responsiveness to rTMS is largely
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Consensus on rapid screening for prodromal Alzheimer’s disease in China Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Lin Huang, Qinjie Li, Yao Lu, Fengfeng Pan, Liang Cui, Ying Wang, Ya Miao, Tianlu Chen, Yatian Li, Jingnan Wu, Xiaochun Chen, Jianping Jia, Qihao Guo
Alzheimer’s disease (AD) is a common cause of dementia, characterised by cerebral amyloid-β deposition, pathological tau and neurodegeneration. The prodromal stage of AD (pAD) refers to patients with mild cognitive impairment (MCI) and evidence of AD’s pathology. At this stage, disease-modifying interventions should be used to prevent the progression to dementia. Given the inherent heterogeneity of
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Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Yuan Li, Peiying Li, Mengyuan Yuan, Yonghan Li, Xueying Zhang, Juan Chen, Gengfu Wang, Puyu Su
Background In early adolescence, youth are highly prone to suicidal behaviours. Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies. Aims To explore the risk and protective factors of suicidal behaviours (ie, suicidal ideation, plans and attempts) in early adolescence in China using a social-ecological perspective. Methods Using
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Pregnancy stressors and postpartum symptoms of depression and anxiety: the moderating role of a cognitive–behavioural therapy (CBT) intervention Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Yunxiang Sun, Soim Park, Abid Malik, Najia Atif, Ahmed Zaidi, Atif Rahman, Pamela J Surkan
Background Little is known about the association between stressors (especially positive stressors) during pregnancy and postpartum depression and anxiety. Aims We investigated the association between positive and negative stress events during different stages of pregnancy and postpartum mental health outcomes among low-income pregnant women with symptoms of anxiety in Pakistan and evaluated whether
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Exploring the influences of education, intelligence and income on mental disorders Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Ancha Baranova, Hongbao Cao, Fuquan Zhang
Background Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major mental disorders are unclear. Aims We aimed to evaluate the overall and independent causal effects of the three psychosocial factors on common mental disorders. Methods Using genome-wide association study
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Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Yunxi Zhong, Yifan Chen, Xiaoying Su, Meiqi Wang, Qixiu Li, Ziming Shao, Long Sun
Background Bipolar disorder is identified as a cause of severe damage to the physical, psychological and social functioning of adolescents and young adults. Aims The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10–24 years at global, regional and national levels from 1990 to 2019. Methods The data analysed in this study were from the Global Burden
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Age-related differences in long-term potentiation-like plasticity and short-latency afferent inhibition and their association with cognitive function Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Qian Lu, Sisi Huang, Tianjiao Zhang, Jie Song, Manyu Dong, Yilun Qian, Jing Teng, Tong Wang, Chuan He, Ying Shen
Background The neurophysiological differences in cortical plasticity and cholinergic system function due to ageing and their correlation with cognitive function remain poorly understood. Aims To reveal the differences in long-term potentiation (LTP)-like plasticity and short-latency afferent inhibition (SAI) between older and younger individuals, alongside their correlation with cognitive function
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Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Junzhe Cheng, Hongkun Hu, Yumeng Ju, Jin Liu, Mi Wang, Bangshan Liu, Yan Zhang
The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites
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Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Jiahao Zhu, Houpu Liu, Rui Gao, Lilu Ding, Jing Wang, Ye Yang, Dan Zhou, Yingjun Li
Background Educational inequalities in suicide have become increasingly prominent over the past decade. Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities. Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their
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Comparisons of transcranial alternating current stimulation and repetitive transcranial magnetic stimulation treatment therapy for insomnia: a pilot study Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Ziqiang Shao, Yongjian Guo, Lirong Yue, Xiaoyang Liu, Jiayi Liu, Xumeng Zhao, Xiaona Sheng, Dahua Yu, Yifei Zhu, Kai Yuan
To the editor: Insomnia disorder has a serious and widespread detrimental effect on humans with comorbidity with other mental or physical health problems.1 2 In recent years, non-invasive brain stimulation (NIBS) techniques, especially transcranial magnetic stimulation (TMS) and transcranial electrical stimulation, have been increasingly used for the treatment of brain diseases, including insomnia
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Suicide, self-injury and violence Gen. Psychiatry (IF 11.9) Pub Date : 2024-02-01 Kexin Zhang, Ziyang Wang, Xin Yu
To the editor: Non-suicidal self-injury (NSSI) is defined as direct, repetitive self-injury to bodily tissues without suicidal intent.1 The estimated prevalence of NSSI among adolescents is 17.2% worldwide2 with a comparable rate observed in China.3 As a behavioural addiction,4 NSSI poses a significant suicide risk,5 and is emerging as a major mental health problem among adolescents. To unravel this
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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Chengzhang Liu, Qiguo Meng, Yuanxiu Wei, Xinyue Su, Yuanyuan Zhang, Panpan He, Chun Zhou, Mengyi Liu, Ziliang Ye, Xianhui Qin
Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain. Aims To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy, older Chinese individuals. Methods The study included a total of 3106 participants capable of completing repeated cognitive function tests
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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Panpan Hu, Qiuchen Cao, Hu Feng, Yun Liu, Yan Chen, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Chun Wang, Junying Gao, Ming Xiao
Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but the pathophysiological mechanism remains elusive. Aims To explore the mechanism of microRNA-451a (miR-451a) in the pathology and behaviours of depression. Methods Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse
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Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Viktor H Ahlqvist, Christina Dardani, Paul Madley-Dowd, Harriet Forbes, Jessica Rast, Caichen Zhong, Renee M Gardner, Christina Dalman, Kristen Lyall, Craig Newschaffer, Torbjörn Tomson, Michael Lundberg, Daniel Berglind, Neil M Davies, Brian K Lee, Cecilia Magnusson, Dheeraj Rai
Background Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood. Aim We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these conditions. Methods Using nationwide Swedish health registries, we quantified the lifetime
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Advances in functional MRI research in bipolar disorder: from the perspective of mood states Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Yankun Wu, Yun-Ai Su, Linlin Zhu, Jitao Li, Tianmei Si
Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and depression. Current breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar disorder. However, the pathophysiology underlying mood instability, mood switching and the development of extreme mood states is less well understood. This review presents a comprehensive overview
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Yaying Cao, Gaohong Zhu, Chengwu Feng, Jing Chen, Wei Gan, Yuan Ma, Yonghua Hu, Klodian Dhana, Trudy Voortman, Jie Shen, Ting Li, Yan Zheng, Changzheng Yuan, Geng Zong
Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure, while the role of genetics and incident cardiovascular disease (CVD) remains unclear. Aims To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample, and to explore the role of genetics
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The burden of depression, anxiety and schizophrenia among the older population in ageing and aged countries: an analysis of the Global Burden of Disease Study 2019 Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Ying Cheng, Yu Fang, Jinxin Zheng, Shiyang Guan, Meiti Wang, Wu Hong
Background Depression, anxiety and schizophrenia among older persons have become global public health challenges. However, the burden of these disorders in ageing and aged countries has not been analysed. Aims To investigate the burden of depression, anxiety and schizophrenia among older adults in ageing and aged countries. Methods Using data from the Global Burden of Disease Study 2019, we calculated
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Effects of a periodic intermittent theta burst stimulation in Alzheimer’s disease Gen. Psychiatry (IF 11.9) Pub Date : 2024-01-01 Xingqi Wu, Yibing Yan, Panpan Hu, Lu Wang, Yue Wu, Pan Wu, Zhi Geng, Guixian Xiao, Shanshan Zhou, Gongjun Ji, Bensheng Qiu, Ling Wei, Yanghua Tian, Hesheng Liu, Kai Wang
Background Previous studies have demonstrated that excitatory repetitive transcranial magnetic stimulation (rTMS) can improve the cognitive function of patients with Alzheimer’s disease (AD). Intermittent theta burst stimulation (iTBS) is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment
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Modulatory effects of transcutaneous auricular vagus nerve stimulation (taVNS) on attentional processes Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Yuxin Chen, Haoyu Yang, Faguang Wang, Xuejing Lu, Li Hu
Background The modulatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) on attention has varied in previous studies. This inconsistency might be attributed to the combined influence of the modulation effect on the different attentional functions, including alerting, orienting and executive control. Aims We aimed to preliminarily examine the modulatory effects of taVNS on different
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Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Gangbin Han, Guirong Cheng, Feifei Hu, Chunli Li, Dan Liu, Juan Zhou, Jing Liu, Linya Huang, Xiaochang Liu, Qianqian Nie, Dan Song, Deyang Zeng, Lang Xu, Jinquan Li, Yushan Chen, Zhen Wei, Qiong Wu, Xiaoming He, Qingming Wu, Wei Tan, Yufei Mei, Xingxing Chen, Yangming Ou, Jingjing Zhang, Yafu Yu, Mengliu Yang, Pengfei Lian, Fukai Zhou, Renjia Fan, Hong Wan, Chenlu Hu, Yidi Fu, Shiyue Li, Junyi Wang
The impact of the coronavirus disease 2019 (COVID-19) pandemic in 2020 on mental health was substantial in China1 2 and various other countries.3 4 Beyond the direct consequences of COVID-19, the pandemic created an environment in which many determinants of mental health were affected. Issues associated with the pandemic, such as loss of livelihood, limited access to medical services, reduced social
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Connectome-based predictive modelling can predict follow-up craving after abstinence in individuals with opioid use disorders Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Wenhan Yang, Jungong Han, Jing Luo, Fei Tang, Li Fan, Yanyao Du, Longtao Yang, Jun Zhang, Huiting Zhang, Jun Liu
Background Individual differences have been detected in individuals with opioid use disorders (OUD) in rehabilitation following protracted abstinence. Recent studies suggested that prediction models were effective for individual-level prognosis based on neuroimage data in substance use disorders (SUD). Aims This prospective cohort study aimed to assess neuroimaging biomarkers for individual response
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Social isolation, loneliness and subsequent risk of major adverse cardiovascular events among individuals with type 2 diabetes mellitus Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Yannis Yan Liang, Yilin Chen, Hongliang Feng, Huachen Xue, Yu Nie, Qi-Yong H Ai, Jiacheng Ma, Lulu Yang, Jihui Zhang, Sizhi Ai
Background Individuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared with the general population; however, there are few relevant studies investigating this issue. Aims To investigate whether social isolation or loneliness may be associated with subsequent risk of developing major adverse cardiovascular events, whether these associations vary according to
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Cooperation between China and Iran in addiction medicine: opportunities, challenges and strategies Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Gangliang Zhong, Hang Su, Di Zhao, Ji Hu, Xing Liu, Yonghui Li, Saeed Semnanian, Abbas Haghparast, Ti-Fei Yuan, Jiang Du
Addiction is a major global risk factor for disability and premature death1 and has become a public health and social problem worldwide. Despite substantial investments from governments and research institutions globally, current addiction medicine research remains centred in Western countries. However, theories, models and results from western-centric research may not be applicable to different cultures
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Effectiveness of pharmacogenomics on the response and remission of treatment-resistant depression: a meta-analysis of randomised controlled trials Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Yu Cheng, Hongmei Liu, Ruixue Yuan, Kai Yuan, Shunying Yu
Background Pharmacogenomics (PGx) is a promising tool to realise tailored drug therapy for depression. Aims To investigate the treatment efficacy of PGx for treatment-resistant depression (TRD) compared with treatment as usual. Methods A systematic search was conducted in PubMed, Embase, the Cochrane Library, Web of Science and PsycINFO to identify relevant studies published from inception to 15 April
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Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Hean Teik Ong, Jinghong Chen
Increasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction (MI) or direct myocardial injury. Mental stress leads to systemic inflammation. Inflammation is known to cause rapid atheromatous plaque progression, instability
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Electroencephalography microstates as novel functional biomarkers for insomnia disorder Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Yongjian Guo, Xumeng Zhao, Xiaoyang Liu, Jiayi Liu, Yan Li, Lirong Yue, Fulai Yuan, Yifei Zhu, Xiaona Sheng, Dahua Yu, Kai Yuan
Background Insomnia disorder (ID) is one of the most common mental disorders. Research on ID focuses on exploring its mechanism of disease, novel treatments and treatment outcome prediction. An emerging technique in this field is the use of electroencephalography (EEG) microstates, which offer a new method of EEG feature extraction that incorporates information from both temporal and spatial dimensions
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Enhancing pain modulation: the efficacy of synchronous combination of virtual reality and transcutaneous electrical nerve stimulation Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Yanzhi Bi, Xu Liu, Xiangyue Zhao, Shiyu Wei, Jingwei Li, Faguang Wang, Wenbo Luo, Li Hu
Introduction Virtual reality (VR) and transcutaneous electrical nerve stimulation (TENS) have emerged as effective interventions for pain reduction. However, their standalone applications often yield limited analgesic effects, particularly in certain painful conditions. Aims Our hypothesis was that the combination of VR with TENS in a synchronous manner could produce the best analgesic effect among
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Exploring the potential of the metaverse medical paradigm in drug addiction treatment: a preliminary discussion and future prospects Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Longtao Yang, Lijie Zhang, Wenhan Yang, Fei Tang, Yanyao Du, Jun Liu
Drug addiction is a chronic and recurrent encephalopathy characterised by impulsive behaviour, spiritual cravings, psychological distortion and physical damage.1 According to the role of molecular biology mechanisms on the central nervous system, addictive substances can be classified as inhibitors (eg, opioids, etc), stimulants (eg, methamphetamine (MA), nicotine, cocaine, etc) and hallucinogens (eg
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Increased odds of high body mass index in depression with self-reported antidepressant use Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Vanessa K Tassone, Shakila Meshkat, Hilary Pang, Michelle Wu, Sophie F Duffy, Hyejung Jung, Wendy Lou, Venkat Bhat
To the editor: The incidence of depression and obesity is on the rise, posing significant public health concerns. While the literature largely supports a positive correlation between depression and body mass index (BMI),1 2 earlier studies have suggested an inverse relationship3 or indicated a lack of association between depression and obesity.4 Monoaminergic antidepressants, such as selective serotonin
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Suicide trends among patients with cancer in India over the past 24 years Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 M Swathi Shenoy, Ashish Wasudeo Khobragade, Muthathal Subramanian
Suicide is a significant global public health concern, claiming over 0.7 million lives annually. It is seen in all age groups and is the fourth leading cause of mortality in the 15–29 year old age group. Three-quarters of suicides are reported in low-income and middle-income countries.1 Notably, India significantly contributes to this global burden, reporting 164 000 suicides in 2021.2 Cancer is one
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High frequency strong current tACS:a new dawn of non-drug therapy for patients with major depressive disorder Gen. Psychiatry (IF 11.9) Pub Date : 2023-12-01 Linling Hu, Xingxing Li, Dongsheng Zhou, Shaochang Wu
A commentary on: Transcranial alternating current stimulation for treating depression: a randomized controlled trial. By Wang H, Wang K, Xue Q, et al . Brain. 2022;1451:83-91.doi:10.1093/brain/awab252. Major depressive disorder (MDD) is a common severe mental illness with recurring episodes. The most commonly used treatment is drug therapy, which is associated with a series of side effects and has
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Single-nucleus transcriptome profiling of prefrontal cortex induced by chronic methamphetamine treatment Gen. Psychiatry (IF 11.9) Pub Date : 2023-11-01 Kuan Zeng, Xuan Yu, Zhen Wei, Yong Wu, Jianzhi Wang, Rong Liu, Yi Li, Xiaochuan Wang
Background Methamphetamine (METH) addiction causes a huge burden on society. The prefrontal cortex (PFC), associated with emotion and cognitive behaviours, is also involved in addiction neurocircuitry. Although bulk RNA sequencing has shown METH-induced gene alterations in the mouse PFC, the impact on different cell types remains unknown. Aims To clarify the effects of METH treatment on different cell
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Uncovering potential distinctive acoustic features of healing music Gen. Psychiatry (IF 11.9) Pub Date : 2023-11-01 Yue Ding, Jiaqi Jing, Qihui Guo, Jiajia Zhou, Xinyao Cheng, Xiaoya Chen, Lihui Wang, Yingying Tang, Qing Fan
Background Music therapy is a promising complementary intervention for addressing various mental health conditions. Despite evidence of the beneficial effects of music, the acoustic features that make music effective in therapeutic contexts remain elusive. Aims This study aimed to identify and validate distinctive acoustic features of healing music. Methods We constructed a healing music dataset (HMD)
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Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with Alzheimer’s disease Gen. Psychiatry (IF 11.9) Pub Date : 2023-11-01 Xingxing Li, Lei Chen, Kunqiang Yu, Wenhao Zhuang, Hui Zhu, Wenqiang Xu, Hui Yan, Gangqiao Qi, Dongsheng Zhou, Shaochang Wu
Background Non-invasive brain stimulation has improved cognitive functions in patients with Alzheimer’s disease (AD), and some studies suggest a close relationship between cognition and plasticity. However, the clinical benefits of transcranial direct current stimulation (tDCS) in patients still need to be evaluated. Aims This study examined the role of tDCS in improving cognition and whether the improved
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Correction: Development of a psychosocial functioning questionnaire for patients with major depressive disorder Gen. Psychiatry (IF 11.9) Pub Date : 2023-11-01 BMJ Publishing Group Ltd
Zhang X, Yang H, Ma H, et al . Development of a …
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Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study Gen. Psychiatry (IF 11.9) Pub Date : 2023-11-01 Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Xiukun Jin, Liucen Tan, Na Pan, Xuedi Wang, Jie Wang, Keming Gao, Xiangyang Zhang, Hongxing Wang
#### WHAT IS ALREADY KNOWN ON THIS TOPIC #### WHAT THIS STUDY ADDS #### HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY Major depressive disorder (MDD) is a principal cause of disability worldwide and is often associated with high morbidity and mortality rates. Although there are several therapies available for the treatment of depression, about one-third of patients with MMD will not respond
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Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Wenlei Zhang, Jiahui Zhou, Hang Su, Xiaocheng Zhang, Weichen Song, Zijing Wang, Chengjie Tang, Kadir Uludağ, Min Zhao, Zhi-Qi Xiong, Rongwei Zhai, Haifeng Jiang
Background Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals. Aims The aim of the study was to investigate changes in BDNF levels during METH self-administration
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Deciphering the ‘gut–brain axis’ through microbiome diversity Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Jinyuan Liu, Ke Xu, Tsungchin Wu, Lydia Yao, Tanya T Nguyen, Dilip Jeste, Xinlian Zhang
Incentivised by breakthroughs and data generated by the high-throughput sequencing technology, this paper proposes a distance-based framework to fulfil the emerging needs in elucidating insights from the high-dimensional microbiome data in psychiatric studies. By shifting focus from traditional methods that focus on the observations from each subject to the between-subject attributes that aggregate
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Cost-benefit and discriminant validity of a stepwise dementia case-finding approach in an Asian older adult community Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Ting Pang, Binte Xia, Xuhao Zhao, Yaping Zhang, Cheuk Ni Kan, Saima Hilal, Christopher Chen, Narayanaswamy Venketasubramanian, Wong Tien Yin, Ching-Yu Cheng, Changzheng Yuan, Xin Xu
Background Case-finding is a recommended approach for dementia early detection in the community. Aims To investigate the discriminant validity and cost-effectiveness of a stepwise dementia case-finding approach in a Singaporean older adult community. Methods The two-phase study was conducted in the community from 2009 to 2015 in Singapore. A total of 3780 participants (age ≥60 years) completed phase
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Promising applications of non-invasive brain stimulation on military cognition enhancement: a long way to go Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Xiaolong Sun, Hua Yuan
Cognitive function encompasses a wide range of brain functions, such as attention and working memory, all of which are essential for the effective functioning of ordinary people in their work and daily lives. However, military personnel constitute a unique occupational group, necessitating the ability to process complex environments and multiple critical events concurrently over extended durations
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Time to treat the climate and nature crisis as one in divisible global health emergency Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Chris Zielinski
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and
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High-definition transcranial direct current stimulation over the right dorsolateral prefrontal cortex reduces risk-taking Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Wei Li, Shuyue Zhang, Xinyu He, Jiawen Hu, Jia Shi, Qinghua He
Taking risks is essential for daily life,1 as it reflects an individual’s inclination towards activities that may have positive outcomes despite the possibility of negative results, such as losses or harm.2 Insufficiency in risk-taking can lead to addictive behaviours and other mental health issues.2 The Balloon Analogue Risk Task (BART)3 is a commonly used method to assess risk-taking behaviour.4
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Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Luyao Wang, Rongyang Xu, Chengying Huang, Guozhong Yi, Zhiyong Li, Huayang Zhang, Rongxu Ye, Songtao Qi, Guanglong Huang, Shanqiang Qu
Depression is a major contributor to poor global health and disability, with a recently increasing incidence. Although drug therapy is commonly used to treat depression, conventional antidepressant drugs have several disadvantages, including slow onset, low response rates and severe adverse effects. Therefore, developing effective therapies for depression remains challenging. Although various aetiological
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Development of the Life Gatekeeper suicide prevention training programme in China: a Delphi study Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Chengxi Cai, Chen Yin, Yongsheng Tong, Diyang Qu, Yunzhi Ding, Daixi Ren, Peiyu Chen, Yi Yin, Jing An, Runsen Chen
Background Youth suicide has been a pressing public mental health concern in China, yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents. Aims The current Delphi study was the first step in the systematic development of the Life Gatekeeper programme, the first gatekeeper programme to be developed locally in China that aims to equip
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Chinese herbal medicine combined with cognitive–behavioural therapy for avoidant paruresis: a controlled trial Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Shijie Liang, Ying Zhou, Chao Yu, Xiang Gao, Fangbin Ji, Qianyuan Fang, Zhihang Zhang, Libin Yang, Youkang Zhao, Yuhui Zhao, Renwu Yin, Kaimin Chen, Zheng Lu
Background Avoidant paruresis is a common clinical condition in urology and psychosomatic medicine. However, it has limited treatment options that are safe and effective with few side effects. Aims Our study aimed to investigate the effectiveness and safety of the Chinese herbal Yangxin Tongquan decoction combined with cognitive–behavioural therapy (CBT) for avoidant paruresis. Methods Sixty-eight
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Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease: a phase I/II clinical trial Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Xinyi Xie, Qingxiang Song, Chengxiang Dai, Shishuang Cui, Ran Tang, Suke Li, Jing Chang, Ping Li, Jintao Wang, Jianping Li, Chao Gao, Hongzhuan Chen, Shengdi Chen, Rujing Ren, Xiaoling Gao, Gang Wang
Background There have been no effective treatments for slowing or reversing Alzheimer’s disease (AD) until now. Growing preclinical evidence, including this study, suggests that mesenchymal stem cells-secreted exosomes (MSCs-Exos) have the potential to cure AD. Aims The first three-arm, drug-intervention, phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human
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Lower synaptic density associated with gaming disorder: an 18F-SynVesT-1 PET imaging study Gen. Psychiatry (IF 11.9) Pub Date : 2023-10-01 Jiale Hou, Qian Xiao, Ming Zhou, Ling Xiao, Ming Yuan, Na Zhong, Jiang Long, Tao Luo, Shuo Hu, Huixi Dong
Background Internet gaming disorder (IGD) is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use. Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD. Aims This study aimed to determine whether subjects with IGD have lower
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Deep magnetic stimulation targeting the medial prefrontal and anterior cingulate cortices for methamphetamine use disorder: a randomised, double-blind, sham-controlled study Gen. Psychiatry (IF 11.9) Pub Date : 2023-09-01 Di Zhao, Ningning Zeng, Hang-Bin Zhang, Yi Zhang, Jiatong Shan, Huichun Luo, Abraham Zangen, Ti-Fei Yuan
#### What is already known on this topic #### What this study adds #### How this study might affect research, practice or policy Craving is a key component of substance use disorders (SUDs).1 In recent decades, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising treatment for individuals with SUDs by reducing their drug cravings and drug-associated cues, including methamphetamine
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Cognitive control subprocess deficits and compensatory modulation mechanisms in patients with frontal lobe injury revealed by EEG markers: a basic study to guide brain stimulation Gen. Psychiatry (IF 11.9) Pub Date : 2023-09-01 Sinan Liu, Chaoqun Shi, Huanhuan Meng, Yu Meng, Xin Gong, Xiping Chen, Luyang Tao
Background Frontal lobe injury (FLI) is related to cognitive control impairments, but the influences of FLI on the internal subprocesses of cognitive control remain unclear. Aims We sought to identify specific biomarkers for long-term dysfunction or compensatory modulation in different cognitive control subprocesses. Methods A retrospective case-control study was conducted. Event-related potentials
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Adverse childhood experiences from family and society contribute to increased risk of depressive symptoms and cognitive impairment: a cross-sectional study Gen. Psychiatry (IF 11.9) Pub Date : 2023-09-01 Ziyang Ren, Yanan Luo, Xiaoying Zheng, Jufen Liu
Background Family environments can shape children’s personalities and social networks, rendering distinguishing adverse childhood experiences (ACEs) from family and society essential, but related evidence remains limited. Aims This cross-sectional study aimed to investigate the correlations between intrafamilial and social ACEs, their associations with depressive symptoms and cognitive impairment and
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Resting-state electroencephalography theta predicts neurofeedback treatment 4-month follow-up response in nicotine addiction Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Qiujian Meng, Ying Zhu, Ye Yuan, Li Yang, Jiafang Liu, Xiaochu Zhang, Junjie Bu
Background The high rate of long-term relapse is a major cause of smoking cessation failure. Recently, neurofeedback training has been widely used in the treatment of nicotine addiction; however, approximately 30% of subjects fail to benefit from this intervention. Our previous randomised clinical trial (RCT) examined cognition-guided neurofeedback and demonstrated a significant decrease in daily cigarette
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Neuro-11: a new questionnaire for the assessment of somatic symptom disorder in general hospitals Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Silin Zeng, Yian Yu, Shan Lu, Sirui Zhang, Xiaolin Su, Ge Dang, Ying Liu, Zhili Cai, Siyan Chen, Yitao He, Xin Jiang, Chanjuan Chen, Lei Yuan, Peng Xie, Jianqing Shi, Qingshan Geng, Rafael H Llinas, Yi Guo
Background Somatic symptom disorder (SSD) commonly presents in general hospital settings, posing challenges for healthcare professionals lacking specialised psychiatric training. The Neuro-11 Neurosis Scale (Neuro-11) offers promise in screening and evaluating psychosomatic symptoms, comprising 11 concise items across three dimensions: somatic symptoms, negative emotions and adverse events. Prior research
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Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Baichuan Wu, Huifeng Zhang, Jinghong Chen, Jiaye Chen, Zhifen Liu, Yuqi Cheng, Tifei Yuan, Daihui Peng
Background Non-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms of NSSI in MDD remain elusive. Aims To review present evidence related to the potential mechanisms of NSSI in MDD. Methods According to Preferred Reporting Items for Systematic Reviews
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Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Ziyang Ren, Binbin Su, Yushan Du, Tianjing Zhou, Xiaoying Zheng, Jufen Liu
Background Adverse childhood experiences (ACEs) and dementia are associated and comorbid with obesity. However, according to emerging research, the role of obesity in the association between ACEs and dementia seems controversial. Aims This analysis aimed to explore the associations between ACEs and different dementia subtypes and the effect modification of long-term body mass index (BMI). Methods Data
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What do we know about pseudodementia? Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Salomé Mouta, Isabel Fonseca Vaz, Miguel Pires, Sara Ramos, Diana Figueiredo
Depression and dementia can lead to generalised cognitive and memory dysfunction. Thus, differentiating these disorders is important and challenging. Pseudodementia is a term used clinically to describe symptoms that resemble dementia but are caused by other conditions (most frequently depression), rather than being recognised as an official diagnosis. Pseudodementia is characterised by a cognitive
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Effect of gender on the association between cumulative cardiovascular risk factors and depression: results from the US National Health and Nutrition Examination Survey Gen. Psychiatry (IF 11.9) Pub Date : 2023-08-01 Sen Li, Zhaoqi Jia, Zhang Zhang, Yuxin Li, Yining Ding, Zongshi Qin, Shuzhen Guo
Background The comorbidity of cardiovascular disease (CVD) and depression has been well established, as depression usually presents simultaneously with CVD risk factors. However, the potential association between cumulative exposure to CVD risk and depression remains unclear, so we conducted the current investigation. To our knowledge, this is the first study that employs the cumulative risk model