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Copy number variant risk loci for schizophrenia converge on the BDNF pathway World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-03-17 Friederike Ehrhart, Ana Silva, Therese van Amelsvoort, Emma vonScheibler, Chris Evelo, David E.J. Linden
Objectives: Schizophrenia genetics is complex, and the contribution of common and rare variants are not fully understood. Several specific copy number variations (CNVs) confer increased risk, and t...
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P300 Parameters in Major Depressive Disorder: A Systematic Review and Meta-Analysis World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-03-17 Mehmet Kemal Arıkan, Reyhan İlhan, Özden Orhan, Muhammed Taha Esmeray, Şenol Turan, Şakir Gica, Hasan Bakay, Oliver Pogarell, Kâşif Nevzat Tarhan, Barış Metin
Objectives: Event-related potential measures have been extensively studied in mental disorders. Among them, P300 amplitude and latency reflect impaired cognitive abilities in major depressive disor...
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Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation´s clinical response in schizophrenia – results from a secondary analysis World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-03-17 Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E. Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan, Elias Wagner
Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge...
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Corticosteroids and mania: a systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-02-16 Mathias DeBock, Pascal Sienaert
Objectives: Corticosteroids are widely prescribed for a variety of medical conditions. Accumulating evidence suggests that their use may be associated with adverse psychiatric effects, including ma...
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Interactive neuroinflammation pathways and transcriptomics-based identification of drugs and chemical compounds for schizophrenia World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-01-31 Lisa Koole, Pilar Martinez-Martinez, Therese van Amelsvoort, Chris T. Evelo, Friederike Ehrhart
Schizophrenia is a psychiatric disorder affecting 1% of the population. Accumulating evidence indicates that neuroinflammation is involved in the pathology of these disorders by altering neurodevel...
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The effect of deep repetitive transcranial magnetic stimulation with an H1 coil on hopelessness in patients with major depressive disorder: A randomized controlled trial World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-01-07 Tomislav Gajšak, Željko Milovac, Natko Gereš, Strahimir Sučić, Zoran Zoričić, Igor Filipčić
To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) with an H1 coil as a treatment for hopelessness in patients with major depressive disorder (MDD).We conducted a randomi...
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Common changes in rat cortical gene expression after valproate or lithium treatment particularly affect pre- and post-synaptic pathways that regulate four neurotransmitters systems World J. Biol. Psychiatry (IF 3.1) Pub Date : 2024-01-07 Brian Dean, Elizabeth Scarr
We have postulated that common changes in gene expression after treatment with different therapeutic classes of psychotropic drugs contribute to their common therapeutic mechanisms of action.To tes...
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Glucose-6-phosphate dehydrogenase deficiency and psychotic disorders: A systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-12-29 Christopher Gandar, James G. Scott, Nicola Warren
Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) is the most common enzymopathy globally. Early studies suggested an association with severe psychotic illness; however, changes to laboratory tes...
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Gender differences in brain region activation during verbal fluency task as detected by fNIRS in patients with depression World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-11-24 Hailong Lyu, Miaomiao Zhao, Pengfeng Xu, Ying Li, Chaonan Jiang, Haoyang Zhao, Wenjing Shen, Xiaohan Hu, Kaiqi Wang, Yi Xu, Manli Huang
Background: Gender plays a role in the mechanisms of depression, but fewer studies have focused on gender differences in the abnormal activation of brain regions when patients perform specific cogn...
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Interactive neuroinflammation pathways and transcriptomics-based identification of drugs and chemical compounds for schizophrenia World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-11-14 Lisa Koole, Pilar Martinez-Martinez, Therese van Amelsvoort, Chris T. Evelo, Friederike Ehrhart
Objectives: Schizophrenia is a psychiatric disorder affecting 1% of the population. Accumulating evidence indicates that neuroinflammation is involved in the pathology of these disorders by alterin...
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Repetitive transcranial magnetic stimulation and fluoxetine attenuate astroglial activation and benefit behaviors in a chronic unpredictable mild stress mouse model of depression World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-11-09 Qianfa Yuan, Yuying Lei, Kai Yu, Junnan Wu, Zhizhong Xu, Chunyan Wen, Yanlong Liu, Wenqiang Wang, Jue He
Repetitive transcranial magnetic stimulation (rTMS) has been considered as an effective antidepressant treatment; however, the mechanism of its antidepressant effect is still unclear. Fluoxetine, a...
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The Relationship between Alterations in Plasma Metabolites and Treatment Responses in Antipsychotic-Naïve Female Patients with Schizophrenia World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-10-22 Xiaoli Wang, Jun Xie, Hongyun Ma, Gang Li, Meijuan Li, Shen Li, Xiaoxiao Sun, Yongping Zhao, Wei Sun, Shu Yang, Jie Li
This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 antipsyc...
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Brain functional connectivity of hypnosis without target suggestion. An intrinsic hypnosis rs-fMRI study. World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-10-02 Pablo G. Vázquez, Susan Whitfield-Gabrieli, Clemens C. C. Bauer, Fernando A. Barrios
During hypnosis, significant changes in the BOLD signal associated with the anterior default mode network (DMN) and prefrontal attentional systems have been reported as evidence of dissociation def...
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The Effect of Deep Repetitive Transcranial Magnetic Stimulation with an H1 Coil on Hopelessness in Patients with Major Depressive Disorder: A Randomized Controlled Trial World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-20 Tomislav Gajšak, Željko Milovac, Natko Gereš, Strahimir Sučić, Zoran Zoričić, Igor Filipčić
Objectives: To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) with an H1 coil as treatment for hopelessness in patients with major depressive disorder (MDD).Methods: We ...
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Common changes in rat cortical gene expression after valproate or lithium treatment particularly affect pre- and post-synaptic pathways that regulate four neurotransmitters systems. World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-18 Brian Dean, Elizabeth Scarr
We have postulated that common changes in gene expression after treatment with different therapeutic classes of psychotropic drugs contribute to their common therapeutic mechanisms of action.To tes...
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Peripheral Blood MicroRNAs as Biomarkers of Schizophrenia: Expectations from A Meta-Analysis That Combines Deep Learning Methods World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-13 Shiyuan Han, Yongning Li, Jun Gaoa
Abstract Objectives This study aimed at identifying reliable differentially expressed miRNAs (DEMs) for schizophrenia in blood via meta-analyses combined with deep learning methods. Methods First, we meta-analysed published DEMs. Then, we enriched the pool of schizophrenia-associated miRNAs by applying two computational learning methods to identify candidate biomarkers and verified the results in external
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The Involvement of the Adrenergic System in Feeding and Eating Disorders. A systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-11 Jacopo Pruccoli, Antonia Parmeggiani, Duccio Maria Cordelli, Marcello Lanari
Abstract Background Adrenergic dysregulation has been proposed as a possible underlying mechanism in Feeding and Eating Disorders (FED). This review aims to synthesize the current evidence on the role of adrenergic dysregulation in the pathogenesis and management of FED. Methods A systematic review was conducted in MEDLINE, Cochrane Library, and Clinicaltrials.gov. The Preferred Reporting Items for
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Peripheral blood MicroRNAs as biomarkers of schizophrenia: expectations from a meta-analysis that combines deep learning methods World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-13 Shiyuan Han, Yongning Li, Jun Gao
This study aimed at identifying reliable differentially expressed miRNAs (DEMs) for schizophrenia in blood via meta-analyses combined with deep learning methods.First, we meta-analysed published DE...
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The involvement of the adrenergic system in feeding and eating disorders. A systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-09-11 Jacopo Pruccoli, Antonia Parmeggiani, Duccio Maria Cordelli, Marcello Lanari
Adrenergic dysregulation has been proposed as a possible underlying mechanism in feeding and eating disorders (FED). This review aims to synthesise the current evidence on the role of adrenergic dy...
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The administration of rhBmal1 reduces sleep deprivation-induced anxiety and cognitive impairment in mice World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-28 Linqing Qi, Youdi Cheng, Shan Sun, Hao Wan
Abstract Background Sleep deprivation results in an increased demand for sleep, cognitive decline, enhanced metabolic rate, and even mortality. In mammals, circadian rhythms control metabolism, immunological response, and reproductive processes. Bmal1 (brain and muscle Arnt-like protein-1) is a key element in the regulation of circadian rhythms. Methods This investigation explores the pathophysiological
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Task fMRI studies investigating inhibitory control in patients with obsessive-compulsive disorder and eating disorders: A Comparative Meta-analysis World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-28 Zheqin Li, Geya Tong, Yang Wang, Hanyang Ruan, Zhen Wang
Abstract Background Obsessive-compulsive disorder (OCD) and eating disorders (EDs) share similarities in terms of clinical characteristics and deficits in inhibitory control. Objective To investigate whether inhibitory control could serve as a common behavioral phenotype between OCD and EDs and whether it might be underpinned by shared and/or distinct neural signatures. Method We performed a quantitative
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The administration of rhBmal1 reduces sleep deprivation-induced anxiety and cognitive impairment in mice World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-28 Linqing Qi, Youdi Cheng, Shan Sun, Hao Wan
In mammals, circadian rhythms control metabolism, immunological response and reproductive processes. Bmal1 (brain and muscle Arnt-like protein-1) is a key element in the regulation of circadian rhy...
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Task fMRI studies investigating inhibitory control in patients with obsessive-compulsive disorder and eating disorders: A comparative meta-analysis World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-28 Zheqin Li, Geya Tong, Yang Wang, Hanyang Ruan, Zifeng Zheng, Jiayue Cheng, Zhen Wang
Obsessive-compulsive disorder (OCD) and eating disorders (EDs) share similarities in terms of clinical characteristics and deficits in inhibitory control.To investigate whether inhibitory control c...
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BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-09 Aurélie Lacroix, Nicolas Ramoz, Murielle Girard, Brigitte Plansont, Daphnée Poupon, Philip Gorwood, Philippe Nubukpo
Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations.Twelve patients with AUD were asses...
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Post-COVID-19 depression and serum interleukin 6 levels: A systematic review and meta-analysis of COVID-19 convalescents with and without depression World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-07 Homa Seyedmirzaei, Mahsa Faramarzpour, Amene Saghazadeh, Antônio L. Teixeira, Nima Rezaei
Depression is among the psychiatric sequelae of COVID-19, affecting more than 20% of the convalescents. Its underlying pathophysiology remains unclear. Interleukin 6 (IL-6), a pro-inflammatory cyto...
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Electroacupuncture alleviates depression-like behaviours via a neural mechanism involving activation of Nucleus Accumbens Shell World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-08-02 Hua-Min Zhang, Zhe-Yu Chen
This study investigated the effects of electroacupuncture (EA) on the depression-like behaviours in a mouse model of chronic restraint stress (CRS) and explored the underlying neural mechanisms.Dep...
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Loneliness during the Covid-19 pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-07-31 N. M. von Werthern, K. F. Ahrens, R. J. Neumann, B. Kollmann, T. M. Kranz, K. Lieb, O. Tüscher, A. Reif, C. J. Fiebach, M. M. Plichta
The outbreak of Covid-19 negatively affected mental health and increased loneliness. The subjective feeling of loneliness is influenced by genetic and social factors and has a negative impact on me...
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Short term ketamine treatment in patient with bipolar disorder with comorbidity with borderline personality disorder: Focus on impulsivity World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-07-25 Maria Gałuszko-Węgielnik, Katarzyna Jakuszkowiak-Wojten, Alina Wilkowska, Wiesław Jerzy Cubała
Borderline personality disorder (BPD) and bipolar disorder (BD) often co-occur and frequently do not respond adequately to traditional antidepressant treatments. Ketamine has shown rapid antidepres...
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Differentiating melancholic and non-melancholic depression via biological markers: A review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-06-16 Michael J. Spoelma, Anastasia Serafimovska, Gordon Parker
Melancholia is a severe form of depression that is typified by greater genetic and biological influence, distinct symptomatology, and preferential response to physical treatment. This paper sought ...
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Multiple genes encoding mitochondrial ribosomes are downregulated in brain and blood samples of individuals with schizophrenia World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-05-31 Gideon Bartal, Assif Yitzhaky, Aviv Segev, Libi Hertzberg
Schizophrenia is a chronic, debilitating mental disorder whose pathophysiology is complex and not fully understood. Numerous studies suggest mitochondrial dysfunction may contribute to the developm...
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A systematic review and meta-analysis of optical coherence tomography studies in schizophrenia, bipolar disorder and major depressive disorder World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-05-25 Akash Prasannakumar, Vijay Kumar, Pooja Mailankody, Abhishek Appaji, Rajani Battu, Tos T. J. M. Berendschot, Naren P. Rao
Due to the common neurodevelopmental origin and easy accessibility, the retina serves as a surrogate marker for changes in the brain. Hence, Optical Coherence Tomography (OCT), a tool to examine th...
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Association between programmed death-1 pathway and major depression World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-05-15 Kuan-Wei Huang, Tiao-Lai Huang
Major depression (MD) may be associated with inflammation and immunity. PD-1 (programmed death-1), PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2) are among the inhibitory i...
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Red cell distribution width and depressive symptoms: A failed replication in female adolescents World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-05-15 Valentin Kriegmair, Christine Sigrist, Jasper Vöckel, Michael Kaess, Julian Koenig
Despite the increasingly high prevalence and serious consequences of depression in adolescents, there is a lack of economical and reliable biomarkers to aid the diagnostic process. Recent findings ...
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Long-term treatment of adult ADHD in a naturalistic setting: Clinical predictors of attrition, medication choice, improvement, and response World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-28 Giulio Emilio Brancati, Francesco De Dominicis, Alessandra Petrucci, Alessandro Pallucchini, Marco Carli, Pierpaolo Medda, Elisa Schiavi, Pietro De Rossi, Stefano Vicari, Giulio Perugi
Abstract Objectives The aim of this study was to identify clinical predictors of treatment attrition, medication choice, improvement and response to pharmacotherapy in adult attention-deficit/hyperactivity disorder (ADHD). Methods 150 ADHD patients were enrolled and naturalistically followed-up for at least 4 months. Conners’ Adult ADHD Rating Scales–Observer: Screening Version (CAARS-O:SV) were used
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World Federation of Societies of Biological Psychiatry (WFSBP) guidelines update 2023 on the pharmacological treatment of eating disorders World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-24 Hubertus Himmerich, Yael Doreen Lewis, Chiara Conti, Hiba Mutwalli, Andreas Karwautz, Jan Magnus Sjögren, María Mercedes Uribe Isaza, Marta Tyszkiewicz-Nwafor, Martin Aigner, Susan L. McElroy, Janet Treasure, Siegfried Kasper, The WFSBP Task Force on Eating Disorders
This 2023 update of the WFSBP guidelines for the pharmacological treatment of eating disorders (EDs) reflects the latest diagnostic and psychopharmacological progress and the improved WFSBP recomme...
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Basal glutamate in the hippocampus and the dorsolateral prefrontal cortex in schizophrenia: Relationships to cognitive proficiency investigated with structural equation modelling World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-24 Jeffrey A. Stanley, Ana M. Daugherty, Claire Richter Gorey, Patricia Thomas, Dalal Khatib, Asadur Chowdury, Usha Rajan, Luay Haddad, Alireza Amirsadri, Vaibhav A. Diwadkar
Schizophrenia is characterised by deficits across multiple cognitive domains and altered glutamate related neuroplasticity. The purpose was to investigate whether glutamate deficits are related to ...
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Genome-wide DNA methylation analysis in families with multiple individuals diagnosed with schizophrenia and intellectual disability World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-18 Shengmin Zhang, Kaiyu Shi, Nan Lyu, Yunshu Zhang, Guangming Liang, Wufang Zhang, Xijin Wang, Hong Wen, Liping Wen, Hong Ma, Jijun Wang, Xin Yu, Lili Guan
Schizophrenia (SZ) and intellectual disability (ID) are both included in the continuum of neurodevelopmental disorders (NDDs). DNA methylation is known to be important in the occurrence of NDDs. Th...
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Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-13 Suhas Ganesh, TuKiet T. Lam, Rolando Garcia-Milian, Deepak Cyril D'Souza, Angus C. Nairn, Katya Elgert, Erez Eitan, Mohini Ranganathan
Abstract Background Rates of Cannabis Use Disorder (CUD) are highest amongst young adults. Paucity of brain tissue samples limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD. Methods NDEs were extracted using ExoSORT, an immunoaffinity
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Psychiatric onset of prodromal dementia with Lewy bodies: Current insights into neuroimaging tools World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-04-12 Niels Hansen, Sebastian Johannes Müller, Eya Khadhraoui, Marielle Ernst, Christian Heiner Riedel, Jens Wiltfang, Claudia Lange, Carolin Bouter
Abstract Purpose Our article is dedicated to describing the state-of-the-art in imaging techniques for assessing prodromal dementia with Lewy bodies (pro-DLB) with a psychiatric-onset. Materials and methods Imaging biomarker techniques are discussed. Results (123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography (123I-FP-CIT SPECT) seems
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Treatment of depression and borderline personality disorder with 1 Hz repetitive transcranial magnetic stimulation of the orbitofrontal cortex – A pilot study World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-03-15 C. Reinsberg, M. Schecklmann, M. A. Abdelnaim, F. C. Weber, B. Langguth, T. Hebel
Abstract Borderline personality disorder (BPD) is characterised by impairments in emotional regulation, impulse control and interpersonal interaction. Comorbid depression is common. The orbitofrontal cortex (OFC) plays a crucial role in the biological substrate of BPD. We investigated the effects of 1 Hz repetitive transcranial magnetic stimulation (rTMS) targeting the OFC on depressive symptoms and
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Inflammatory and oxidative endophenotypes in borderline personality disorder: A biomarker cluster analysis World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-03-15 J. M. López-Villatoro, M. Díaz-Marsá, A. De la Torre-Luque, K. S. MacDowell, C. Prittwitz, J. C. Leza, J. L. Carrasco
Abstract Objectives This study is designed to search for aggrupation of inflammatory/oxidative biomarker alterations in borderline personality disorder (BPD) and their association with phenotypic features. Methodology Inflammatory/nitrosative proteins were measures in plasma and peripheral blood mononuclear cells obtained from BPD patients. Patients were assessed on different clinical dimensions of
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Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-03-13 Lior Carmi, Joseph Zohar, Alzbeta Juven-Wetzler, Frank Desarnaud, Louri Makotkine, Linda M. Bierer, Hagit Cohen, Rachel Yehuda
Abstract Objectives The ability to identify persons at elevated risk for post-traumatic stress disorder (PTSD) soon after exposure to trauma, could aid clinical decision-making and treatment. In this study, we explored whether cytosine methylation of the 1 F promoter of the NR3C1 (glucocorticoid receptor [GR]) gene obtained immediately following a trauma could predict PTSD. Methods Our sample comprised
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The potential of biomarkers for diagnosing insomnia: Consensus statement of the WFSBP Task Force on Sleep Disorders World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-03-07 Dimitris Dikeos, Adam Wichniak, Periklis Y. Ktonas, Thorsten Mikoteit, Tatjana Crönlein, Anne Eckert, Jana Kopřivová, Maria Ntafouli, Kai Spiegelhalder, Martin Hatzinger, Dieter Riemann, Constantin Soldatos
Thus far, the diagnosis of insomnia is based on purely clinical criteria. Although a broad range of altered physiological parameters has been identified in insomniacs, the evidence to establish the...
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Oral ketamine for depression: An updated systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-01-31 Shakila Meshkat, Sipan Haikazian, Joshua D. Di Vincenzo, Farhan Fancy, Danica Johnson, David Chen-Li, Roger S. McIntyre, Rodrigo Mansur, Joshua D. Rosenblat
Abstract Objectives: Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that can be used to treat major depressive disorder by single or repeated infusions. However, the accessibility and scalability of oral ketamine make it preferred over intravenous ketamine. In this systematic review, we aim to evaluate the efficacy, tolerability, and safety of oral ketamine, esketamine and r-ketamine
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Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia World J. Biol. Psychiatry (IF 3.1) Pub Date : 2023-01-30 Murielle Brum, Matthias Nieberler, Christopher Kehrwald, Katrin Knopf, Nathalie Brunkhorst-Kanaan, Semra Etyemez, Kelly A. Allers, Robert A. Bittner, David A. Slattery, Rhiannon V. McNeill, Andreas Reif, Sarah Kittel-Schneider
Abstract Objectives Kynurenine, kynurenic and quinolinic acid are important metabolites in tryptophan metabolism. Due to an involvement in glutamatergic neurotransmission and immune response, previous studies have investigated this pathway in mental disorders such as major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ). Tryptophan and kynurenine have been shown to be decreased
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Obsessive-compulsive symptoms in two patients with chromosomal disorders involving the X chromosome World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-12-09 Isabelle Matteit, Andrea Schlump, Marco Reisert, Katharina von Zedtwitz, Kimon Runge, Kathrin Nickel, Miriam A. Schiele, Volker A. Coenen, Katharina Domschke, Andreas Tzschach, Dominique Endres
Abstract Introduction The etio-pathophysiology of obsessive-compulsive disorder (OCD) can be explained using a biopsychosocial model. Little is known about obsessive-compulsive symptoms (OCS) in the context of chromosomal disorders involving the X chromosome. Methods Case studies of two patients with chromosomal disorders involving the X chromosome (Patient 1 with a variant of Turner syndrome and Patient
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Decline of stress resilience in aging rats: Focus on choroid plexus-cerebrospinal fluid-hippocampus World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-12-08 Kaige Liu, Huizhen Li, Ningxi Zeng, Wenjun Lu, Xiaofeng Wu, Hanfang Xu, Can Yan, Lili Wu
Abstract Objectives This study was designed to examine the mechanisms underlying decline of stress resilience in aged rats from the perspective of CP-CSF-hippocampus. Methods Male Wistar rats (7–8 weeks old or 20 months old) were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks. The behavioral tests were conducted to assess anxiety, depression and cognitive function. Hippocampal neurogenesis
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The efficacy of neurofeedback for alcohol use disorders – a systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-12-06 Forum Dave, Ravikesh Tripathi
Abstract Background Alcoholism is a serious social, economic and public health problem. Alcoholism can affect the gastrointestinal, neurological, cardiovascular and respiratory systems, and it can be fatal, costing the healthcare system huge amounts of money. Despite the availability of cognitive-behavioural and psychosocial therapies, alcoholism has a high recurrence rate and a dismal prognosis, with
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Use of machine learning to diagnose somatic symptom disorder: Are the biomarkers beneficial for the diagnosis? World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-12-05 Chi-Shin Wu, Shih-Cheng Liao, Wei-Lieh Huang
Abstract Objectives We used machine learning to incorporate three types of biomarkers (respiratory sinus arrhythmia, RSA; skin conductance, SC; finger temperature, FT) for examining the performance of diagnosing somatic symptom disorder (SSD). Methods We recruited 97 SSD subjects and 96 controls without psychiatric history or somatic distress. The values of RSA, SC and FT were recorded in three situations
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The potential association between psychiatric symptoms and the use of levonorgestrel intrauterine devices (LNG-IUDs): A systematic review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-11-25 Mohamed Elsayed, Khaled T. Dardeer, Nimrat Khehra, Inderbir Padda, Heiko Graf, Amr Soliman, Abdelrahman M. Makram, René Zeiss, Carlos Schönfeldt-Lecuona
Abstract Background Levonorgestrel (LNG)-intrauterine devices (IUDs) are an effective method of contraception; however, there is growing evidence regarding potential psychiatric side effects such as depressive symptoms, anxiety, and suicidal thoughts. Therefore, we conducted this systematic review to summarise the psychiatric effects of using LNG-IUDs. Methods We searched six databases (MEDLINE, Web
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Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-11-23 Paola Mangiapane, Manuel Glauco Carbone, Alessandro Arone, Lucia Massa, Stefania Palermo, Walter Flamini, Elisabetta Parra, Benedetto Morana, Florinda Morana, Giovanni Bertini, Donatella Marazziti
Abstract Objectives Vitamin B12, folic acid, and homocysteine play a key role in ‘one-carbon metabolism’, involved in different brain processes. Altered levels have been reported in mood disorders (MDs), particularly in major depression (MDD), while the information in bipolar disorders (BDs) is limited. The present study aimed at assessing vitamin B12, homocysteine, and folic acid in 69 bipolar inpatients
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Blood brain barrier permeability increases with age in individuals with 22q11.2 deletion syndrome World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-11-11 Michal Taler, Ehud Mekori–Domachevsky, Elfi Vergaelen, Stephan Claes, Yaffa Serur, Shira Dar, Yael Levy-Shraga, Abraham Weizman, Ann Swillen, Doron Gothelf
Abstract 22q11.2 deletion syndrome (22q11.2DS) is characterised by high rates of psychotic disorders and immune abnormalities. Blood–brain barrier (BBB) permeability is known to be a risk factor for schizophrenia and immune aberrations. Objective To evaluate the relationship between psychosis and BBB permeability in this population. Methods We examined two biomarkers for BBB permeability, s100β and
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Characterisation of medication side effects in patients with mostly resistant depression in a real-world setting World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-11-11 Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Abstract Objectives This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Methods A total of 1410 depressed patients were treated in a naturalistic setting. Side effects were measured with the Udvalg for Kliniske Undersogelser Side Effect Rating Scale (UKU); the total score and UKU
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Effect of anxiolytic drug silexan on sleep – a narrative review World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-10-19 Erich Seifritz, Siegfried Kasper, Hans-Jürgen Möller, Hans-Peter Volz, Walter E. Müller, Anne Eckert, Martin Hatzinger
Abstract Objectives Silexan is an orally administered, proprietary essential oil from Lavandula angustifolia with significant anxiolytic and sleep improving properties. Here we present a narrative review that provides an overview of the available evidence of the effects of silexan on sleep. Methods We start with a summary of the pharmacological background and continue with presenting sleep-related
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Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-10-19 Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier, Cynthia Marie-Claire
Abstract Objectives An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored
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The relationship between cortisol awakening response and trait resilience in two patient cohorts and one population-based cohort World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-10-14 Patrick Linnemann, Nele Friedrich, Matthias Nauck, Henning Teismann, Klaus Berger
Abstract Objectives We examined (1) the proportion of cortisol awakening non-responders, (2) the association between cortisol awakening response (CAR) and trait resilience, and (3) the association between CAR increase and trait resilience in two patient cohorts (depression and myocardial infarction [CVD]) and one population-based cohort. Methods Eight hundred and eighty study participants delivered
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Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and Australasian Society of Lifestyle Medicine (ASLM) taskforce World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-10-06 Wolfgang Marx, Sam H. Manger, Mark Blencowe, Greg Murray, Fiona Yan-Yee Ho, Sharon Lawn, James A. Blumenthal, Felipe Schuch, Brendon Stubbs, Anu Ruusunen, Hanna Demelash Desyibelew, Timothy G. Dinan, Felice Jacka, Arun Ravindran, Michael Berk, Adrienne O’Neil
Abstract Objectives The primary objectives of these international guidelines were to provide a global audience of clinicians with (a) a series of evidence-based recommendations for the provision of lifestyle-based mental health care in clinical practice for adults with Major Depressive Disorder (MDD) and (b) a series of implementation considerations that may be applicable across a range of settings
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Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-09-28 Iveta Pavlova, Eva Drazanova, Lucie Kratka, Petra Amchova, Ondrej Macicek, Jana Starcukova, Zenon Starcuk, Jana Ruda-Kucerova
Abstract Objectives Pilot study validating the animal model of depression – the bilateral olfactory bulbectomy in rats – by two nuclear magnetic resonance methods, indirectly detecting the metabolic state of the brain. Furthermore, the study focussed on potential differences in brain laterality. Methods Arterial spin labelling assessed cerebral brain flow in prefrontal, sensorimotor, and piriform cortices
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Low α-N-acetylgalactosaminidase plasma concentration correlates with the presence and severity of the bipolar affective disorder World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-09-27 Seda Yilmaz, Pınar Öner
Abstract Objectives Believing that a neurodevelopmental pathology may cause bipolar affective disorder (BAD), we aimed to measure the concentrations of α-N-acetylgalactosaminidase (α-NAGAL), a lysosomal enzyme. Methods The study included 32 patients with BAD and 32 healthy controls. The Young Mania Rating Scale was used to measure the severity of the disease. Serum α-N-acetylgalactosaminidase concentrations
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Agomelatine decreases cocaine-induced locomotor sensitisation and dopamine release in rats World J. Biol. Psychiatry (IF 3.1) Pub Date : 2022-09-27 Susana Barbosa-Méndez, Gilberto Perez-Sánchez, Alberto Salazar-Juárez
Abstract Background Agomelatine is a melatoninergic antidepressant approved to treat the major depressive disorder. Agomelatine exerts its behavioural, pharmacological, and physiological effects through the activation of MT1 and MT2 melatonin receptors and the blockade of 5-HT2B and 5-HT2C serotonin receptors. Some studies have reported that the activation of the MT1 and MT2 melatonin receptors decreased